                         SEQUENCE LISTING

<110>  Isis Pharmaceuticals, Inc.
 
<120>  MODULATION OF APOLIPOPROTEIN CIII (APOCIII) EXPRESSION IN 
       LIPOPROTEIN LIPASE DEFICIENT (LPLD) POPULATIONS

<130>  BIOL0218WO

<150>  61/880,779
<151>  2013-09-20

<150>  61/764,969
<151>  2013-02-14

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  533
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (47)..(346)

<400>  1
tgctcagttc atccctagag gcagctgctc caggaacaga ggtgcc atg cag ccc          55
                                                   Met Gln Pro            
                                                   1                      

cgg gta ctc ctt gtt gtt gcc ctc ctg gcg ctc ctg gcc tct gcc cga        103
Arg Val Leu Leu Val Val Ala Leu Leu Ala Leu Leu Ala Ser Ala Arg           
    5                   10                  15                            

gct tca gag gcc gag gat gcc tcc ctt ctc agc ttc atg cag ggt tac        151
Ala Ser Glu Ala Glu Asp Ala Ser Leu Leu Ser Phe Met Gln Gly Tyr           
20                  25                  30                  35            

atg aag cac gcc acc aag acc gcc aag gat gca ctg agc agc gtg cag        199
Met Lys His Ala Thr Lys Thr Ala Lys Asp Ala Leu Ser Ser Val Gln           
                40                  45                  50                

gag tcc cag gtg gcc cag cag gcc agg ggc tgg gtg acc gat ggc ttc        247
Glu Ser Gln Val Ala Gln Gln Ala Arg Gly Trp Val Thr Asp Gly Phe           
            55                  60                  65                    

agt tcc ctg aaa gac tac tgg agc acc gtt aag gac aag ttc tct gag        295
Ser Ser Leu Lys Asp Tyr Trp Ser Thr Val Lys Asp Lys Phe Ser Glu           
        70                  75                  80                        

ttc tgg gat ttg gac cct gag gtc aga cca act tca gcc gtg gct gcc        343
Phe Trp Asp Leu Asp Pro Glu Val Arg Pro Thr Ser Ala Val Ala Ala           
    85                  90                  95                            

tga gacctcaata ccccaagtcc acctgcctat ccatcctgcg agctccttgg             396

gtcctgcaat ctccagggct gcccctgtag gttgcttaaa agggacagta ttctcagtgc      456

tctcctaccc cacctcatgc ctggcccccc tccaggcatg ctggcctccc aataaagctg      516

gacaagaagc tgctatg                                                     533


<210>  2
<211>  3964
<212>  DNA
<213>  Homo sapiens

<400>  2
ctactccagg ctgtgttcag ggcttggggc tggtggaggg aggggcctga aattccagtg       60

tgaaaggctg agatgggccc gaggcccctg gcctatgtcc aagccatttc ccctctcacc      120

agcctctccc tggggagcca gtcagctagg aaggaatgag ggctccccag gcccaccccc      180

agttcctgag ctcatctggg ctgcagggct ggcgggacag cagcgtggac tcagtctcct      240

agggatttcc caactctccc gcccgcttgc tgcatctgga caccctgcct caggccctca      300

tctccactgg tcagcaggtg acctttgccc agcgccctgg gtcctcagtg cctgctgccc      360

tggagatgat ataaaacagg tcagaaccct cctgcctgtc tgctcagttc atccctagag      420

gcagctgctc caggtaatgc cctctgggga ggggaaagag gaggggagga ggatgaagag      480

gggcaagagg agctccctgc ccagcccagc cagcaagcct ggagaagcac ttgctagagc      540

taaggaagcc tcggagctgg acgggtgccc cccacccctc atcataacct gaagaacatg      600

gaggcccggg aggggtgtca cttgcccaaa gctacacagg gggtggggct ggaagtggct      660

ccaagtgcag gttcccccct cattcttcag gcttagggct ggaggaagcc ttagacagcc      720

cagtcctacc ccagacaggg aaactgaggc ctggagaggg ccagaaatca cccaaagaca      780

cacagcatgt tggctggact ggacggagat cagtccagac cgcaggtgcc ttgatgttca      840

gtctggtggg ttttctgctc catcccaccc acctcccttt gggcctcgat ccctcgcccc      900

tcaccagtcc cccttctgag agcccgtatt agcagggagc cggcccctac tccttctggc      960

agacccagct aaggttctac cttaggggcc acgccacctc cccagggagg ggtccagagg     1020

catggggacc tggggtgccc ctcacaggac acttccttgc aggaacagag gtgccatgca     1080

gccccgggta ctccttgttg ttgccctcct ggcgctcctg gcctctgccc gtaagcactt     1140

ggtgggactg ggctgggggc agggtggagg caacttgggg atcccagtcc caatgggtgg     1200

tcaagcagga gcccagggct cgtccagagg ccgatccacc ccactcagcc ctgctctttc     1260

ctcaggagct tcagaggccg aggatgcctc ccttctcagc ttcatgcagg gttacatgaa     1320

gcacgccacc aagaccgcca aggatgcact gagcagcgtg caggagtccc aggtggccca     1380

gcaggccagg tacacccgct ggcctccctc cccatccccc ctgccagctg cctccattcc     1440

cacccgcccc tgccctggtg agatcccaac aatggaatgg aggtgctcca gcctcccctg     1500

ggcctgtgcc tcttcagcct cctctttcct cacagggcct ttgtcaggct gctgcgggag     1560

agatgacaga gttgagactg cattcctccc aggtccctcc tttctccccg gagcagtcct     1620

agggcgtgcc gttttagccc tcatttccat tttcctttcc tttccctttc tttctctttc     1680

tatttctttc tttctttctt tctttctttc tttctttctt tctttctttc tttctttctt     1740

tctttctttc ctttctttct ttcctttctt tctttccttt ctttctttct ttcctttctt     1800

tctctttctt tctttctttc ctttttcttt ctttccctct cttcctttct ctctttcttt     1860

cttcttcttt tttttttaat ggagtctccc tctgtcacct aggctggagt gcagtggtgc     1920

catctcggct cactgcaacc tccgtctccc gggttcaacc cattctcctg cctcagcctc     1980

ccaagtagct gggattacag gcacgcgcca ccacacccag ctaatttttg tatttttagc     2040

agagatgggg tttcaccatg ttggccaggt tggtcttgaa ttcctgacct caggggatcc     2100

tcctgcctcg gcctcccaaa gtgctgggat tacaggcatg agccactgcg cctggcccca     2160

ttttcctttt ctgaaggtct ggctagagca gtggtcctca gcctttttgg caccagggac     2220

cagttttgtg gtggacaatt tttccatggg ccagcgggga tggttttggg atgaagctgt     2280

tccacctcag atcatcaggc attagattct cataaggagc cctccaccta gatccctggc     2340

atgtgcagtt cacaataggg ttcacactcc tatgagaatg taaggccact tgatctgaca     2400

ggaggcggag ctcaggcggt attgctcact cacccaccac tcacttcgtg ctgtgcagcc     2460

cggctcctaa cagtccatgg accagtacct atctatgact tgggggttgg ggacccctgg     2520

gctaggggtt tgccttggga ggccccacct gacccaattc aagcccgtga gtgcttctgc     2580

tttgttctaa gacctggggc cagtgtgagc agaagtgtgt ccttcctctc ccatcctgcc     2640

cctgcccatc agtactctcc tctcccctac tcccttctcc acctcaccct gactggcatt     2700

agctggcata gcagaggtgt tcataaacat tcttagtccc cagaaccggc tttggggtag     2760

gtgttatttt ctcactttgc agatgagaaa attgaggctc agagcgatta ggtgacctgc     2820

cccagatcac acaactaatc aatcctccaa tgactttcca aatgagaggc tgcctccctc     2880

tgtcctaccc tgctcagagc caccaggttg tgcaactcca ggcggtgctg tttgcacaga     2940

aaacaatgac agccttgacc tttcacatct ccccaccctg tcactttgtg cctcaggccc     3000

aggggcataa acatctgagg tgacctggag atggcagggt ttgacttgtg ctggggttcc     3060

tgcaaggata tctcttctcc cagggtggca gctgtggggg attcctgcct gaggtctcag     3120

ggctgtcgtc cagtgaagtt gagagggtgg tgtggtcctg actggtgtcg tccagtgggg     3180

acatgggtgt gggtcccatg gttgcctaca gaggagttct catgccctgc tctgttgctt     3240

cccctgactg atttaggggc tgggtgaccg atggcttcag ttccctgaaa gactactgga     3300

gcaccgttaa ggacaagttc tctgagttct gggatttgga ccctgaggtc agaccaactt     3360

cagccgtggc tgcctgagac ctcaataccc caagtccacc tgcctatcca tcctgcgagc     3420

tccttgggtc ctgcaatctc cagggctgcc cctgtaggtt gcttaaaagg gacagtattc     3480

tcagtgctct cctaccccac ctcatgcctg gcccccctcc aggcatgctg gcctcccaat     3540

aaagctggac aagaagctgc tatgagtggg ccgtcgcaag tgtgccatct gtgtctgggc     3600

atgggaaagg gccgaggctg ttctgtgggt gggcactgga cagactccag gtcaggcagg     3660

catggaggcc agcgctctat ccaccttctg gtagctgggc agtctctggg cctcagtttc     3720

ttcatctcta aggtaggaat caccctccgt accctgcctt ccttgacagc tttgtgcgga     3780

aggtcaaaca ggacaataag tttgctgata ctttgataaa ctgttaggtg ctgcacaaca     3840

tgacttgagt gtgtgcccca tgccagccac tatgcctggc acttaagttg tcatcagagt     3900

tgagactgtg tgtgtttact caaaactgtg gagctgacct cccctatcca ggccccctag     3960

ccct                                                                  3964


<210>  3
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  3
agcttcttgt ccagctttat                                                   20


<210>  4
<211>  3958
<212>  DNA
<213>  Homo sapiens

<400>  4
ctactccagg ctgtgttcag ggcttggggc tggtggaggg aggggcctga aattccagtg       60

tgaaaggctg agatgggccc gaggcccctg gcctatgtcc aagccatttc ccctctcacc      120

agcctctccc tggggagcca gtcagctagg aaggaatgag ggctccccag gcccaccccc      180

agttcctgag ctcatctggg ctgcagggct ggcgggacag cagcgtggac tcagtctcct      240

agggatttcc caactctccc gcccgcttgc tgcatctgga caccctgcct caggccctca      300

tctccactgg tcagcaggtg acctttgccc agcgccctgg gtcctcagtg cctgctgccc      360

tggagatgat ataaaacagg tcagaaccct cctgcctgtc tgctcagttc atccctagag      420

gcagctgctc caggtaatgc cctctgggga ggggaaagag gaggggagga ggatgaagag      480

gggcaagagg agctccctgc ccagcccagc cagcaagcct ggagaagcac ttgctagagc      540

taaggaagcc tcggagctgg acgggtgccc cccacccctc atcataacct gaagaacatg      600

gaggcccggg aggggtgtca cttgcccaaa gctacatagg gggtggggct ggaagtggct      660

ccaagtgcag gttcccccct cattcttcag gcttagggct ggaggaagcc ttagacagcc      720

cagtcctacc ccagacaggg aaactgaggc ctggagaggg ccagaaatca cccaaagaca      780

cacagcatgt tggctggact ggacggagat cagtccagac cgcaggtgcc ttgatgttca      840

gtctggtggg ttttctgctc catcccaccc acctcccttt gggcctcgat ccctcgcccc      900

tcaccagtcc cccttctgag agcccgtatt agcagggagc cggcccctac tccttctggc      960

agacccagct aaggttctac cttaggggcc acgccacctc cccagggagg ggtccagagg     1020

catggggacc tggggtgccc ctcacaggac acttccttgc aggaacagag gtgccatgca     1080

gccccgggta ctccttgttg ttgccctcct ggcgctcctg gcctctgccc gtaagcactt     1140

ggtgggactg ggctgggggc agggtggagg caacttgggg atcccagtcc caatgggtgg     1200

tcaagcagga gcccagggct cgtccatagg ccgatccacc ccactcagcc ctgctctttc     1260

ctcaggagct tcagaggccg aggatgcctc ccttctcagc ttcatgcagg gctacatgaa     1320

gcacgccacc aagaccgcca aggatgcact gagcagcgtg caggagtccc aggtggccca     1380

gcaggccagg tacacccgct ggcctccctc cccatccccc ctgccagctg cctccattcc     1440

cacccacccc tgccctggtg agatcccaac aatggaatgg aggtgctcca gcctcccctg     1500

ggcctgtgcc tcttcagcct cctctttcct cacagggcct ttgtcaggct gctgcgggag     1560

agatgacaga gttgagactg cattcctccc aggtccctcc tttctcccca gagcagtcct     1620

agggcgcgcc gttttagccc tcatttccat tttcctttcc tttccctttc tttccctttc     1680

tatttctttc tttctttctt tctttctttc tttctttctt tctttctttc tttctttctt     1740

tctttctttc ctttctttct ttcttttctt ctttctttct ttcctttctt tctctttctt     1800

tctttctttc tttccttttt ctttctttcc ctctcttcct ttctctcttt ctttcttctt     1860

cttttttttt taatggagtc tccctctgtc acccaggctg gagtgcagtg gtgccatctc     1920

ggctcactgc aacctccgtc tcccgggttc aacccattct cctgcctcag cctcccaagt     1980

agctgggatt acaggcacgc gccaccacac ccagctaatt tttgtatttt tagcagagat     2040

ggggtttcac catgttggcc aggttggtct tgaattcctg acctcagggg atcctcctgc     2100

ctcggcctcc caaagcgctg ggattacagg catgagccac tgcgcctggc cccattttcc     2160

ttttctgaag gtctggctag agcagtggtc ctcagccttt ttggcaccag ggaccagttt     2220

tgtggtggac aatttttcca tgggccagcg gggatggttt tgggatgaag ctgttccacc     2280

tcagatcatc aggcattaga ttctcataag gagccctcca cctagatccc tggcatgtgc     2340

agttcacaac agggttcaca ctcctatgag aatgtaaggc cacttgatct gacaggaggc     2400

ggagctcagg cggtattgct cactcaccca ccactcactt cgtgctgtgc agcccggctc     2460

ctaacagtcc atggaccagt acctatctat gacttggggg ttggggaccc ctgggctagg     2520

ggtttgcctt gggaggcccc acctgaccta attcaagccc gtgagtgctt ctgctttgtt     2580

ctaagacctg gggccagtgt gagcagaagt gtgtccttcc tctcccatcc tgcccctgcc     2640

catcagtact ctcctctccc ctactccctt ctccacctca ccctgactgg cattagctgg     2700

catagcagag gtgttcataa acattcttag tccccagaac cggctttggg gtaggtgtta     2760

ttttctcact ttgcagatga gaaaattgag gctcagagcg attaggtgac ctgccccaga     2820

tcacacaact aatcaatcct ccaatgactt tccaaatgag aggctgcctc cctctgtcct     2880

accctgctca gagccaccag gttgtgcaac tccaggcggt gctgtttgca cagaaaacaa     2940

tgacagcctt gacctttcac atctccccac cctgtcactt tgtgcctcag gcccaggggc     3000

ataaacatct gaggtgacct ggagatggca gggtttgact tgtgctgggg ttcctgcaag     3060

gatatctctt ctcccagggt ggcagctgtg ggggattcct gcctgaggtc tcagggctgt     3120

cgtccagtga agttgagagg gtggtgtggt cctgactggt gtcgtccagt ggggacatgg     3180

gtgtgggtcc catggttgcc tacagaggag ttctcatgcc ctgctctgtt gcttcccctg     3240

actgatttag gggctgggtg accgatggct tcagttccct gaaagactac tggagcaccg     3300

ttaaggacaa gttctctgag ttctgggatt tggaccctga ggtcagacca acttcagccg     3360

tggctgcctg agacctcaat accccaagtc cacctgccta tccatcctgc cagctccttg     3420

ggtcctgcaa tctccagggc tgcccctgta ggttgcttaa aagggacagt attctcagtg     3480

ctctcctacc ccacctcatg cctggccccc ctccaggcat gctggcctcc caataaagct     3540

ggacaagaag ctgctatgag tgggccgtcg caagtgtgcc atctgtgtct gggcatggga     3600

aagggccgag gctgttctgt gggtgggcac tggacagact ccaggtcagg caggcatgga     3660

ggccagcgct ctatccacct tctggtagct gggcagtctc tgggcctcag tttcttcatc     3720

tctaaggtag gaatcaccct ccgtaccctg ccttccttga cagctttgtg cggaaggtca     3780

aacaggacaa taagtttgct gatactttga taaactgtta ggtgctgcac aacatgactt     3840

gagtgtgtgc cccatgccag ccactatgcc tggcacttaa gttgtcatca gagttgagac     3900

tgtgtgtgtt tactcaaaac tgtggagctg acctccccta tccaggccac ctagccct       3958

