                         SEQUENCE LISTING

<110>  Wu, Chia-Yung
       Onuffer, James
       Lim, Wendell A
 
<120>  CHIMERIC ANTIGEN RECEPTOR AND METHODS OF USE THEREOF

<130>  UCSF-464WO

<150>  61/765,585
<151>  2013-02-15

<160>  145   

<170>  PatentIn version 3.5

<210>  1
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  1
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  2
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  2

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  3
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  3
gagcagaagc tgatcagcga ggaggacctg                                        30


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  4

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  5
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  5
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg      300

gggaccaagc tggagatcac aggtggcggt ggctcgggcg gtggtgggtc gggtggcggc      360

ggatctgagg tgaaactgca ggagtcagga cctggcctgg tggcgccctc acagagcctg      420

tccgtcacat gcactgtctc aggggtctca ttacccgact atggtgtaag ctggattcgc      480

cagcctccac gaaagggtct ggagtggctg ggagtaatat ggggtagtga aaccacatac      540

tataattcag ctctcaaatc cagactgacc atcatcaagg acaactccaa gagccaagtt      600

ttcttaaaaa tgaacagtct gcaaactgat gacacagcca tttactactg tgccaaacat      660

tattactacg gtggtagcta tgctatggac tactggggcc aaggaacctc agtcaccgtc      720

tcctca                                                                 726


<210>  6
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  6

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  7
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  7
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      180

ctgtcactgg ttatcaccct ttactgc                                          207


<210>  8
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  8

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  9
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  9
tccctaggaa gcgggtccgg tagcggatct                                        30


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  10

Ser Leu Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10  


<210>  11
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  11
atgggagtcc aggtggaaac catctcccca ggagacgggc gcaccttccc caagcgcggc       60

cagacctgcg tggtgcacta caccgggatg cttgaagatg gaaagaaatt tgattcctcc      120

cgggacagaa acaagccctt taagtttatg ctaggcaagc aggaggtgat ccgaggctgg      180

gaagaagggg ttgcccagat gagtgtgggt cagagagcca aactgactat atctccagat      240

tatgcctatg gtgccactgg gcacccaggc atcatcccac cacatgccac tctcgtcttc      300

gatgtggagc ttctaaaact ggaa                                             324


<210>  12
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  12

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105             


<210>  13
<211>  282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  13
atgatcctct ggcatgagat gtggcatgaa ggcctggaag aggcatctcg tttgtacttt       60

ggggaaagga acgtgaaagg catgtttgag gtgctggagc ccttgcatgc tatgatggaa      120

cggggccccc agactctgaa ggaaacatcc tttaatcagg cctatggtcg agatttaatg      180

gaggcccaag agtggtgcag gaagtacatg aaatcaggga atgtcaagga cctcctccaa      240

gcctgggacc tctattatca tgtgttccga cgaatctcaa ag                         282


<210>  14
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  14

Met Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser 
1               5                   10                  15      


Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu 
            20                  25                  30          


Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu 
        35                  40                  45              


Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu 
    50                  55                  60                  


Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln 
65                  70                  75                  80  


Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys 
                85                  90                  


<210>  15
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  15
ggaagcgggt ccggtagcgg atcttcccta                                        30


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  16

Gly Ser Gly Ser Gly Ser Gly Ser Ser Leu 
1               5                   10  


<210>  17
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  17
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  18
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  18

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  19
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  19
tcgcgaggaa gcgggtccgg tagcggatct                                        30


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  20

Ser Arg Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10  


<210>  21
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  21
atggtgagca agggcgagga ggataacatg gccatcatca aggagttcat gcgcttcaag       60

gtgcacatgg agggctccgt gaacggccac gagttcgaga tcgagggcga gggcgagggc      120

cgcccctacg agggcaccca gaccgccaag ctgaaggtga ccaagggtgg ccccctgccc      180

ttcgcctggg acatcctgtc ccctcagttc atgtacggct ccaaggccta cgtgaagcac      240

cccgccgaca tccccgacta cttgaagctg tccttccccg agggcttcaa gtgggagcgc      300

gtgatgaact tcgaggacgg cggcgtggtg accgtgaccc aggactcctc cctgcaggac      360

ggcgagttca tctacaaggt gaagctgcgc ggcaccaact tcccctccga cggccccgta      420

atgcagaaga agaccatggg ctgggaggcc tcctccgagc ggatgtaccc cgaggacggc      480

gccctgaagg gcgagatcaa gcagaggctg aagctgaagg acggcggcca ctacgacgct      540

gaggtcaaga ccacctacaa ggccaagaag cccgtgcagc tgcccggcgc ctacaacgtc      600

aacatcaagt tggacatcac ctcccacaac gaggactaca ccatcgtgga acagtacgaa      660

cgcgccgagg gccgccactc caccggcggc atggacgagc tgtacaag                   708


<210>  22
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  22

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235     


<210>  23
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  23
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  24
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  24

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  25
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  25
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgcct cctcgc                                336


<210>  26
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  26

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  27
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  27
atgatccatc tgggtcacat cctcttcctg cttttgctcc cagtggctgc agctcagacg       60

actccaggag agagatcatc actccctgcc ttttaccctg gcacttcagg ctcttgttcc      120

ggatgtgggt ccctctctct gccg                                             144


<210>  28
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  28

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


<210>  29
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  29
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  30
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  30

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  31
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  31
ggttccggca gcggatctgg tagcggaagc gggtccggta gcggatct                    48


<210>  32
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  32

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


<210>  33
<211>  279
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  33
atcctctggc atgagatgtg gcatgaaggc ctggaagagg catctcgttt gtactttggg       60

gaaaggaacg tgaaaggcat gtttgaggtg ctggagccct tgcatgctat gatggaacgg      120

ggcccccaga ctctgaagga aacatccttt aatcaggcct atggtcgaga tttaatggag      180

gcccaagagt ggtgcaggaa gtacatgaaa tcagggaatg tcaaggacct cctccaagcc      240

tgggacctct attatcatgt gttccgacga atctcaaag                             279


<210>  34
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  34

Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg 
1               5                   10                  15      


Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu 
            20                  25                  30          


Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr 
        35                  40                  45              


Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp 
    50                  55                  60                  


Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala 
65                  70                  75                  80  


Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys 
                85                  90              


<210>  35
<211>  1857
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  35
atgccagacc ccgcggcgca tctgcccttc ttctacggca gcatctcgcg tgccgaggcc       60

gaggagcacc tgaagctggc gggcatggcg gacgggctct tcctgctgcg ccagtgcctg      120

cgctcgctgg gcggctatgt gctgtcgctc gtgcacgatg tgcgcttcca ccactttccc      180

atcgagcgcc agctcaacgg cacctacgcc attgccggcg gcaaagcgca ctgtggaccg      240

gcagagctct gcgagttcta ctcgcgcgac cccgacgggc tgccctgcaa cctgcgcaag      300

ccgtgcaacc ggccgtcggg cctcgagccg cagccggggg tcttcgactg cctgcgagac      360

gccatggtgc gtgactacgt gcgccagacg tggaagctgg agggcgaggc cctggagcag      420

gccatcatca gccaggcccc gcaagtggag aagctcattg ctacgacggc ccacgagcgg      480

atgccctggt accacagcag cctgacgcgt gaggaggccg agcgcaaact ttactctggg      540

gcgcagaccg acggcaagtt cctgctgagg ccgcggaagg agcagggcac atacgccctg      600

tccctcatct atgggaagac ggtgtaccac tacctcatca gccaagacaa ggcgggcaag      660

tactgcattc ccgagggcac caagtttgac acgctctggc agctggtgga gtatctgaag      720

ctgaaggcgg acgggctcat ctactgcctg aaggaggcct gccccaacag cagtgccagc      780

aacgcctcag gggctgctgc tcccacactc ccagcccacc catccacgtt gactcatcct      840

cagagacgaa tcgacaccct caactcagat ggatacaccc ctgagccagc acgcataacg      900

tccccagaca aaccgcggcc gatgcccatg gacacgagcg tgtatgagag cccctacagc      960

gacccagagg agctcaagga caagaagctc ttcctgaagc gcgataacct cctcatagct     1020

gacattgaac ttggctgcgg caactttggc tcagtgcgcc agggcgtgta ccgcatgcgc     1080

aagaagcaga tcgacgtggc catcaaggtg ctgaagcagg gcacggagaa ggcagacacg     1140

gaagagatga tgcgcgaggc gcagatcatg caccagctgg acaaccccta catcgtgcgg     1200

ctcattggcg tctgccaggc cgaggccctc atgctggtca tggagatggc tgggggcggg     1260

ccgctgcaca agttcctggt cggcaagagg gaggagatcc ctgtgagcaa tgtggccgag     1320

ctgctgcacc aggtgtccat ggggatgaag tacctggagg agaagaactt tgtgcaccgt     1380

gacctggcgg cccgcaacgt cctgctggtt aaccggcact acgccaagat cagcgacttt     1440

ggcctctcca aagcactggg tgccgacgac agctactaca ctgcccgctc agcagggaag     1500

tggccgctca agtggtacgc acccgaatgc atcaacttcc gcaagttctc cagccgcagc     1560

gatgtctgga gctatggggt caccatgtgg gaggccttgt cctacggcca gaagccctac     1620

aagaagatga aagggccgga ggtcatggcc ttcatcgagc agggcaagcg gatggagtgc     1680

ccaccagagt gtccacccga actgtacgca ctcatgagtg actgctggat ctacaagtgg     1740

gaggatcgcc ccgacttcct gaccgtggag cagcgcatgc gagcctgtta ctacagcctg     1800

gccagcaagg tggaagggcc cccaggcagc acacagaagg ctgaggctgc ctgtgcc        1857


<210>  36
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  36

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  the amino acids in this region can be repeated n times, where n 
       is an integer of at least one

<400>  37

Gly Ser Gly Gly Ser 
1               5   


<210>  38
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide


<220>
<221>  REPEAT
<222>  (1)..(4)
<223>  the amino acids in this region can be repeated n times, where n 
       is an integer of at least one

<400>  38

Gly Gly Gly Ser 
1               


<210>  39
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  39

Gly Gly Ser Gly 
1               


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  40

Gly Gly Ser Gly Gly 
1               5   


<210>  41
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  41

Gly Ser Gly Ser Gly 
1               5   


<210>  42
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  42

Gly Ser Gly Gly Gly 
1               5   


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  43

Gly Gly Gly Ser Gly 
1               5   


<210>  44
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  44

Gly Ser Ser Ser Gly 
1               5   


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  45

Asp Lys Thr His Thr 
1               5   


<210>  46
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  46

Cys Pro Pro Cys 
1               


<210>  47
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  47

Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
1               5                   10                  15  


<210>  48
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  48

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  49
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  49

Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10  


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  50

Lys Cys Cys Val Asp Cys Pro 
1               5           


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  51

Lys Tyr Gly Pro Pro Cys Pro 
1               5           


<210>  52
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  52

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  53
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  53

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  54
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  54

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro 
    


<210>  55
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  55

Ser Pro Asn Met Val Pro His Ala His His Ala Gln 
1               5                   10          


<210>  56
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  56

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  57
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  57

Leu Gly Leu Leu Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly 
1               5                   10                  15      


Val Ala Ile His Leu Cys Cys 
            20              


<210>  58
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  58

Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly 
1               5                   10                  15      


Leu Gly Ile Phe Phe Cys Val Arg Cys 
            20                  25  


<210>  59
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  59

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu Arg Val 
            20              


<210>  60
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  60

Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
1               5                   10                  15      


Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25      


<210>  61
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  61

Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      


Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
            20                  25      


<210>  62
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  62

Ala Leu Pro Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu Gly 
1               5                   10                  15      


Leu Gly Val Ala Cys Val Leu Ala 
            20                  


<210>  63
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  63

Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
1               5                   10                  15      


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
            20                  25                  30          


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40                  


<210>  64
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  64

Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
1               5                   10                  15      


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
            20                  25                  30          


Val Thr Leu 
        35  


<210>  65
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  65

Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
1               5                   10                  15      


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            20                  25                  30          


Thr Leu Ala Lys Ile 
        35          


<210>  66
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  66

Cys Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr 
1               5                   10                  15      


Ala Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln 
            20                  25                  30          


Thr Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr 
        35                  40                  45              


Gly Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly 
    50                  55                  60                  


Ser Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile 
65                  70                  75                  80  


Val Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu 
                85                  90                  95      


Ala Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val 
            100                 105                 110         


Arg Ser 
        


<210>  67
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  67

His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu 
1               5                   10                  15      


Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser 
            20                  25                  30          


Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser 
        35                  40                  45              


Pro 
    


<210>  68
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  68

Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu Cys Tyr 
1               5                   10                  15      


Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser Arg Pro 
            20                  25                  30          


Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr Glu Pro 
        35                  40                  45              


Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu Thr Cys 
    50                  55                  60                  


His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln Asp Ala 
65                  70                  75                  80  


Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu Pro Arg 
                85                  90                  95      


Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr Ile Met 
            100                 105                 110         


Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu Pro Glu 
        115                 120                 125             


Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu Glu Leu 
    130                 135                 140                 


Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu Pro Pro 
145                 150                 155                 160 


Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu Gly Lys 
                165                 170                 175     


Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
            180                 185         


<210>  69
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  69

His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln 
1               5                   10                  15      


Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln 
            20                  25                  30          


Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg 
        35                  40                  45              


Leu Gly Asp Leu Trp Val 
    50                  


<210>  70
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  70

Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val 
1               5                   10                  15      


Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile 
            20                  25                  30          


Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu 
        35                  40                  45              


Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
    50                  55                  60  


<210>  71
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  71

Leu Glu Glu Ser Val Ala Leu Arg Ile Ile Thr Glu Gly Ala Ser Ile 
1               5                   10                  15      


Leu Arg Gln Glu Lys Asn Leu Leu Asp Ile Asp Ala Pro Val Thr Val 
            20                  25                  30          


Cys Gly Asp Ile His Gly Gln Phe Phe Asp Leu Met Lys Leu Phe Glu 
        35                  40                  45              


Val Gly Gly Ser Pro Ala Asn Thr Arg Tyr Leu Phe Leu Gly Asp Tyr 
    50                  55                  60                  


Val Asp Arg Gly Tyr Phe Ser Ile Glu Cys Val Leu Tyr Leu Trp Ala 
65                  70                  75                  80  


Leu Lys Ile Leu Tyr Pro Lys Thr Leu Phe Leu Leu Arg Gly Asn His 
                85                  90                  95      


Glu Cys Arg His Leu Thr Glu Tyr Phe Thr Phe Lys Gln Glu Cys Lys 
            100                 105                 110         


Ile Lys Tyr Ser Glu Arg Val Tyr Asp Ala Cys Met Asp Ala Phe Asp 
        115                 120                 125             


Cys Leu Pro Leu Ala Ala Leu Met Asn Gln Gln Phe Leu Cys Val His 
    130                 135                 140                 


Gly Gly Leu Ser Pro Glu Ile Asn Thr Leu Asp Asp Ile Arg Lys Leu 
145                 150                 155                 160 


Asp Arg Phe Lys Glu Pro Pro Ala Tyr Gly Pro Met Cys Asp Ile Leu 
                165                 170                 175     


Trp Ser Asp Pro Leu Glu Asp Phe Gly Asn Glu Lys Thr Gln Glu His 
            180                 185                 190         


Phe Thr His Asn Thr Val Arg Gly Cys Ser Tyr Phe Tyr Ser Tyr Pro 
        195                 200                 205             


Ala Val Cys Glu Phe Leu Gln His Asn Asn Leu Leu Ser Ile Leu Arg 
    210                 215                 220                 


Ala His Glu Ala Gln Asp Ala Gly Tyr Arg Met Tyr Arg Lys Ser Gln 
225                 230                 235                 240 


Thr Thr Gly Phe Pro Ser Leu Ile Thr Ile Phe Ser Ala Pro Asn Tyr 
                245                 250                 255     


Leu Asp Val Tyr Asn Asn Lys Ala Ala Val Leu Lys Tyr Glu Asn Asn 
            260                 265                 270         


Val Met Asn Ile Arg Gln Phe Asn Cys Ser Pro His Pro Tyr Trp Leu 
        275                 280                 285             


Pro Asn Phe Met 
    290         


<210>  72
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  72

Met Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu Pro 
1               5                   10                  15      


Leu Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr 
            20                  25                  30          


Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr 
        35                  40                  45              


Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly 
    50                  55                  60                  


Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly 
65                  70                  75                  80  


Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly 
                85                  90                  95      


Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe 
            100                 105                 110         


Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val 
        115                 120                 125             


Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg 
    130                 135                 140                 


Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp 
145                 150                 155                 160 


Cys Gly Gln Leu Glu 
                165 


<210>  73
<211>  804
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  73

Met Ser Asn Ser Tyr Asp Ser Ser Ser Ile Lys Val Leu Lys Gly Leu 
1               5                   10                  15      


Asp Ala Val Arg Lys Arg Pro Gly Met Tyr Ile Gly Asp Thr Asp Asp 
            20                  25                  30          


Gly Thr Gly Leu His His Met Val Phe Glu Val Val Asp Asn Ala Ile 
        35                  40                  45              


Asp Glu Ala Leu Ala Gly His Cys Lys Glu Ile Ile Val Thr Ile His 
    50                  55                  60                  


Ala Asp Asn Ser Val Ser Val Gln Asp Asp Gly Arg Gly Ile Pro Thr 
65                  70                  75                  80  


Gly Ile His Pro Glu Glu Gly Val Ser Ala Ala Glu Val Ile Met Thr 
                85                  90                  95      


Val Leu His Ala Gly Gly Lys Phe Asp Asp Asn Ser Tyr Lys Val Ser 
            100                 105                 110         


Gly Gly Leu His Gly Val Gly Val Ser Val Val Asn Ala Leu Ser Gln 
        115                 120                 125             


Lys Leu Glu Leu Val Ile Gln Arg Glu Gly Lys Ile His Arg Gln Ile 
    130                 135                 140                 


Tyr Glu His Gly Val Pro Gln Ala Pro Leu Ala Val Thr Gly Glu Thr 
145                 150                 155                 160 


Glu Lys Thr Gly Thr Met Val Arg Phe Trp Pro Ser Leu Glu Thr Phe 
                165                 170                 175     


Thr Asn Val Thr Glu Phe Glu Tyr Glu Ile Leu Ala Lys Arg Leu Arg 
            180                 185                 190         


Glu Leu Ser Phe Leu Asn Ser Gly Val Ser Ile Arg Leu Arg Asp Lys 
        195                 200                 205             


Arg Asp Gly Lys Glu Asp His Phe His Tyr Glu Gly Gly Ile Lys Ala 
    210                 215                 220                 


Phe Val Glu Tyr Leu Asn Lys Asn Lys Thr Pro Ile His Pro Asn Ile 
225                 230                 235                 240 


Phe Tyr Phe Ser Thr Glu Lys Asp Gly Ile Gly Val Glu Val Ala Leu 
                245                 250                 255     


Gln Trp Asn Asp Gly Phe Gln Glu Asn Ile Tyr Cys Phe Thr Asn Asn 
            260                 265                 270         


Ile Pro Gln Arg Asp Gly Gly Thr His Leu Ala Gly Phe Arg Ala Ala 
        275                 280                 285             


Met Thr Arg Thr Leu Asn Ala Tyr Met Asp Lys Glu Gly Tyr Ser Lys 
    290                 295                 300                 


Lys Ala Lys Val Ser Ala Thr Gly Asp Asp Ala Arg Glu Gly Leu Ile 
305                 310                 315                 320 


Ala Val Val Ser Val Lys Val Pro Asp Pro Lys Phe Ser Ser Gln Thr 
                325                 330                 335     


Lys Asp Lys Leu Val Ser Ser Glu Val Lys Ser Ala Val Glu Gln Gln 
            340                 345                 350         


Met Asn Glu Leu Leu Ala Glu Tyr Leu Leu Glu Asn Pro Thr Asp Ala 
        355                 360                 365             


Lys Ile Val Val Gly Lys Ile Ile Asp Ala Ala Arg Ala Arg Glu Ala 
    370                 375                 380                 


Ala Arg Arg Ala Arg Glu Met Thr Arg Arg Lys Gly Ala Leu Asp Leu 
385                 390                 395                 400 


Ala Gly Leu Pro Gly Lys Leu Ala Asp Cys Gln Glu Arg Asp Pro Ala 
                405                 410                 415     


Leu Ser Glu Leu Tyr Leu Val Glu Gly Asp Ser Ala Gly Gly Ser Ala 
            420                 425                 430         


Lys Gln Gly Arg Asn Arg Lys Asn Gln Ala Ile Leu Pro Leu Lys Gly 
        435                 440                 445             


Lys Ile Leu Asn Val Glu Lys Ala Arg Phe Asp Lys Met Leu Ser Ser 
    450                 455                 460                 


Gln Glu Val Ala Thr Leu Ile Thr Ala Leu Gly Cys Gly Ile Gly Arg 
465                 470                 475                 480 


Asp Glu Tyr Asn Pro Asp Lys Leu Arg Tyr His Ser Ile Ile Ile Met 
                485                 490                 495     


Thr Asp Ala Asp Val Asp Gly Ser His Ile Arg Thr Leu Leu Leu Thr 
            500                 505                 510         


Phe Phe Tyr Arg Gln Met Pro Glu Ile Val Glu Arg Gly His Val Tyr 
        515                 520                 525             


Ile Ala Gln Pro Pro Leu Tyr Lys Val Lys Lys Gly Lys Gln Glu Gln 
    530                 535                 540                 


Tyr Ile Lys Asp Asp Glu Ala Met Asp Gln Tyr Gln Ile Ser Ile Ala 
545                 550                 555                 560 


Leu Asp Gly Ala Thr Leu His Thr Asn Ala Ser Ala Pro Ala Leu Ala 
                565                 570                 575     


Gly Glu Ala Leu Glu Lys Leu Val Ser Glu Tyr Asn Ala Thr Gln Lys 
            580                 585                 590         


Met Ile Asn Arg Met Glu Arg Arg Tyr Pro Lys Ala Met Leu Lys Glu 
        595                 600                 605             


Leu Ile Tyr Gln Pro Thr Leu Thr Glu Ala Asp Leu Ser Asp Glu Gln 
    610                 615                 620                 


Thr Val Thr Arg Trp Val Asn Ala Leu Val Ser Glu Leu Asn Asp Lys 
625                 630                 635                 640 


Glu Gln His Gly Ser Gln Trp Lys Phe Asp Val His Thr Asn Ala Glu 
                645                 650                 655     


Gln Asn Leu Phe Glu Pro Ile Val Arg Val Arg Thr His Gly Val Asp 
            660                 665                 670         


Thr Asp Tyr Pro Leu Asp His Glu Phe Ile Thr Gly Gly Glu Tyr Arg 
        675                 680                 685             


Arg Ile Cys Thr Leu Gly Glu Lys Leu Arg Gly Leu Leu Glu Glu Asp 
    690                 695                 700                 


Ala Phe Ile Glu Arg Gly Glu Arg Arg Gln Pro Val Ala Ser Phe Glu 
705                 710                 715                 720 


Gln Ala Leu Asp Trp Leu Val Lys Glu Ser Arg Arg Gly Leu Ser Ile 
                725                 730                 735     


Gln Arg Tyr Lys Gly Leu Gly Glu Met Asn Pro Glu Gln Leu Trp Glu 
            740                 745                 750         


Thr Thr Met Asp Pro Glu Ser Arg Arg Met Leu Arg Val Thr Val Lys 
        755                 760                 765             


Asp Ala Ile Ala Ala Asp Gln Leu Phe Thr Thr Leu Met Gly Asp Ala 
    770                 775                 780                 


Val Glu Pro Arg Arg Ala Phe Ile Glu Glu Asn Ala Leu Lys Ala Ala 
785                 790                 795                 800 


Asn Ile Asp Ile 
                


<210>  74
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  74

Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210>  75
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  75

Met Ala Ser Arg Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
1               5                   10                  15      


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
            20                  25                  30          


Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys 
        35                  40                  45              


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
    50                  55                  60                  


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
65                  70                  75                  80  


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
                85                  90                  95      


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105                 110     


<210>  76
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  76

Met Asn Gly Asp Glu Thr Lys Lys Val Glu Ser Glu Tyr Ile Lys Lys 
1               5                   10                  15      


His His Arg His Glu Leu Val Glu Ser Gln Cys Ser Ser Thr Leu Val 
            20                  25                  30          


Lys His Ile Lys Ala Pro Leu His Leu Val Trp Ser Ile Val Arg Arg 
        35                  40                  45              


Phe Asp Glu Pro Gln Lys Tyr Lys Pro Phe Ile Ser Arg Cys Val Val 
    50                  55                  60                  


Gln Gly Lys Lys Leu Glu Val Gly Ser Val Arg Glu Val Asp Leu Lys 
65                  70                  75                  80  


Ser Gly Leu Pro Ala Thr Lys Ser Thr Glu Val Leu Glu Ile Leu Asp 
                85                  90                  95      


Asp Asn Glu His Ile Leu Gly Ile Arg Ile Val Gly Gly Asp His Arg 
            100                 105                 110         


Leu Lys Asn Tyr Ser Ser Thr Ile Ser Leu His Ser Glu Thr Ile Asp 
        115                 120                 125             


Gly Lys Thr Gly Thr Leu Ala Ile Glu Ser Phe Val Val Asp Val Pro 
    130                 135                 140                 


Glu Gly Asn Thr Lys Glu Glu Thr Cys Phe Phe Val Glu Ala Leu Ile 
145                 150                 155                 160 


Gln Cys Asn Leu Asn Ser Leu Ala Asp Val Thr Glu Arg Leu Gln Ala 
                165                 170                 175     


Glu Ser Met Glu Lys Lys Ile 
            180             


<210>  77
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  77

Met Glu Thr Ser Gln Lys Tyr His Thr Cys Gly Ser Thr Leu Val Gln 
1               5                   10                  15      


Thr Ile Asp Ala Pro Leu Ser Leu Val Trp Ser Ile Leu Arg Arg Phe 
            20                  25                  30          


Asp Asn Pro Gln Ala Tyr Lys Gln Phe Val Lys Thr Cys Asn Leu Ser 
        35                  40                  45              


Ser Gly Asp Gly Gly Glu Gly Ser Val Arg Glu Val Thr Val Val Ser 
    50                  55                  60                  


Gly Leu Pro Ala Glu Phe Ser Arg Glu Arg Leu Asp Glu Leu Asp Asp 
65                  70                  75                  80  


Glu Ser His Val Met Met Ile Ser Ile Ile Gly Gly Asp His Arg Leu 
                85                  90                  95      


Val Asn Tyr Arg Ser Lys Thr Met Ala Phe Val Ala Ala Asp Thr Glu 
            100                 105                 110         


Glu Lys Thr Val Val Val Glu Ser Tyr Val Val Asp Val Pro Glu Gly 
        115                 120                 125             


Asn Ser Glu Glu Glu Thr Thr Ser Phe Ala Asp Thr Ile Val Gly Phe 
    130                 135                 140                 


Asn Leu Lys Ser Leu Ala Lys Leu Ser Glu Arg Val Ala His Leu Lys 
145                 150                 155                 160 


Leu 
    


<210>  78
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  78

Met Lys Thr Ser Gln Glu Gln His Val Cys Gly Ser Thr Val Val Gln 
1               5                   10                  15      


Thr Ile Asn Ala Pro Leu Pro Leu Val Trp Ser Ile Leu Arg Arg Phe 
            20                  25                  30          


Asp Asn Pro Lys Thr Phe Lys His Phe Val Lys Thr Cys Lys Leu Arg 
        35                  40                  45              


Ser Gly Asp Gly Gly Glu Gly Ser Val Arg Glu Val Thr Val Val Ser 
    50                  55                  60                  


Asp Leu Pro Ala Ser Phe Ser Leu Glu Arg Leu Asp Glu Leu Asp Asp 
65                  70                  75                  80  


Glu Ser His Val Met Val Ile Ser Ile Ile Gly Gly Asp His Arg Leu 
                85                  90                  95      


Val Asn Tyr Gln Ser Lys Thr Thr Val Phe Val Ala Ala Glu Glu Glu 
            100                 105                 110         


Lys Thr Val Val Val Glu Ser Tyr Val Val Asp Val Pro Glu Gly Asn 
        115                 120                 125             


Thr Glu Glu Glu Thr Thr Leu Phe Ala Asp Thr Ile Val Gly Cys Asn 
    130                 135                 140                 


Leu Arg Ser Leu Ala Lys Leu Ser Glu Lys Met Met Glu Leu Thr 
145                 150                 155                 


<210>  79
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  79

Met Glu Ser Ser Lys Gln Lys Arg Cys Arg Ser Ser Val Val Glu Thr 
1               5                   10                  15      


Ile Glu Ala Pro Leu Pro Leu Val Trp Ser Ile Leu Arg Ser Phe Asp 
            20                  25                  30          


Lys Pro Gln Ala Tyr Gln Arg Phe Val Lys Ser Cys Thr Met Arg Ser 
        35                  40                  45              


Gly Gly Gly Gly Gly Lys Gly Gly Glu Gly Lys Gly Ser Val Arg Asp 
    50                  55                  60                  


Val Thr Leu Val Ser Gly Phe Pro Ala Asp Phe Ser Thr Glu Arg Leu 
65                  70                  75                  80  


Glu Glu Leu Asp Asp Glu Ser His Val Met Val Val Ser Ile Ile Gly 
                85                  90                  95      


Gly Asn His Arg Leu Val Asn Tyr Lys Ser Lys Thr Lys Val Val Ala 
            100                 105                 110         


Ser Pro Glu Asp Met Ala Lys Lys Thr Val Val Val Glu Ser Tyr Val 
        115                 120                 125             


Val Asp Val Pro Glu Gly Thr Ser Glu Glu Asp Thr Ile Phe Phe Val 
    130                 135                 140                 


Asp Asn Ile Ile Arg Tyr Asn Leu Thr Ser Leu Ala Lys Leu Thr Lys 
145                 150                 155                 160 


Lys Met Met Lys 
                


<210>  80
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  80

Met Ala Asn Ser Glu Ser Ser Ser Ser Pro Val Asn Glu Glu Glu Asn 
1               5                   10                  15      


Ser Gln Arg Ile Ser Thr Leu His His Gln Thr Met Pro Ser Asp Leu 
            20                  25                  30          


Thr Gln Asp Glu Phe Thr Gln Leu Ser Gln Ser Ile Ala Glu Phe His 
        35                  40                  45              


Thr Tyr Gln Leu Gly Asn Gly Arg Cys Ser Ser Leu Leu Ala Gln Arg 
    50                  55                  60                  


Ile His Ala Pro Pro Glu Thr Val Trp Ser Val Val Arg Arg Phe Asp 
65                  70                  75                  80  


Arg Pro Gln Ile Tyr Lys His Phe Ile Lys Ser Cys Asn Val Ser Glu 
                85                  90                  95      


Asp Phe Glu Met Arg Val Gly Cys Thr Arg Asp Val Asn Val Ile Ser 
            100                 105                 110         


Gly Leu Pro Ala Asn Thr Ser Arg Glu Arg Leu Asp Leu Leu Asp Asp 
        115                 120                 125             


Asp Arg Arg Val Thr Gly Phe Ser Ile Thr Gly Gly Glu His Arg Leu 
    130                 135                 140                 


Arg Asn Tyr Lys Ser Val Thr Thr Val His Arg Phe Glu Lys Glu Glu 
145                 150                 155                 160 


Glu Glu Glu Arg Ile Trp Thr Val Val Leu Glu Ser Tyr Val Val Asp 
                165                 170                 175     


Val Pro Glu Gly Asn Ser Glu Glu Asp Thr Arg Leu Phe Ala Asp Thr 
            180                 185                 190         


Val Ile Arg Leu Asn Leu Gln Lys Leu Ala Ser Ile Thr Glu Ala Met 
        195                 200                 205             


Asn Arg Asn Asn Asn Asn Asn Asn Ser Ser Gln Val Arg 
    210                 215                 220     


<210>  81
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  81

Met Ser Ser Ser Pro Ala Val Lys Gly Leu Thr Asp Glu Glu Gln Lys 
1               5                   10                  15      


Thr Leu Glu Pro Val Ile Lys Thr Tyr His Gln Phe Glu Pro Asp Pro 
            20                  25                  30          


Thr Thr Cys Thr Ser Leu Ile Thr Gln Arg Ile His Ala Pro Ala Ser 
        35                  40                  45              


Val Val Trp Pro Leu Ile Arg Arg Phe Asp Asn Pro Glu Arg Tyr Lys 
    50                  55                  60                  


His Phe Val Lys Arg Cys Arg Leu Ile Ser Gly Asp Gly Asp Val Gly 
65                  70                  75                  80  


Ser Val Arg Glu Val Thr Val Ile Ser Gly Leu Pro Ala Ser Thr Ser 
                85                  90                  95      


Thr Glu Arg Leu Glu Phe Val Asp Asp Asp His Arg Val Leu Ser Phe 
            100                 105                 110         


Arg Val Val Gly Gly Glu His Arg Leu Lys Asn Tyr Lys Ser Val Thr 
        115                 120                 125             


Ser Val Asn Glu Phe Leu Asn Gln Asp Ser Gly Lys Val Tyr Thr Val 
    130                 135                 140                 


Val Leu Glu Ser Tyr Thr Val Asp Ile Pro Glu Gly Asn Thr Glu Glu 
145                 150                 155                 160 


Asp Thr Lys Met Phe Val Asp Thr Val Val Lys Leu Asn Leu Gln Lys 
                165                 170                 175     


Leu Gly Val Ala Ala Thr Ser Ala Pro Met His Asp Asp Glu 
            180                 185                 190 


<210>  82
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  82

Met Asn Leu Ala Pro Ile His Asp Pro Ser Ser Ser Ser Thr Thr Thr 
1               5                   10                  15      


Thr Ser Ser Ser Thr Pro Tyr Gly Leu Thr Lys Asp Glu Phe Ser Thr 
            20                  25                  30          


Leu Asp Ser Ile Ile Arg Thr His His Thr Phe Pro Arg Ser Pro Asn 
        35                  40                  45              


Thr Cys Thr Ser Leu Ile Ala His Arg Val Asp Ala Pro Ala His Ala 
    50                  55                  60                  


Ile Trp Arg Phe Val Arg Asp Phe Ala Asn Pro Asn Lys Tyr Lys His 
65                  70                  75                  80  


Phe Ile Lys Ser Cys Thr Ile Arg Val Asn Gly Asn Gly Ile Lys Glu 
                85                  90                  95      


Ile Lys Val Gly Thr Ile Arg Glu Val Ser Val Val Ser Gly Leu Pro 
            100                 105                 110         


Ala Ser Thr Ser Val Glu Ile Leu Glu Val Leu Asp Glu Glu Lys Arg 
        115                 120                 125             


Ile Leu Ser Phe Arg Val Leu Gly Gly Glu His Arg Leu Asn Asn Tyr 
    130                 135                 140                 


Arg Ser Val Thr Ser Val Asn Glu Phe Val Val Leu Glu Lys Asp Lys 
145                 150                 155                 160 


Lys Lys Arg Val Tyr Ser Val Val Leu Glu Ser Tyr Ile Val Asp Ile 
                165                 170                 175     


Pro Gln Gly Asn Thr Glu Glu Asp Thr Arg Met Phe Val Asp Thr Val 
            180                 185                 190         


Val Lys Ser Asn Leu Gln Asn Leu Ala Val Ile Ser Thr Ala Ser Pro 
        195                 200                 205             


Thr 
    


<210>  83
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  83

Met Leu Ala Val His Arg Pro Ser Ser Ala Val Ser Asp Gly Asp Ser 
1               5                   10                  15      


Val Gln Ile Pro Met Met Ile Ala Ser Phe Gln Lys Arg Phe Pro Ser 
            20                  25                  30          


Leu Ser Arg Asp Ser Thr Ala Ala Arg Phe His Thr His Glu Val Gly 
        35                  40                  45              


Pro Asn Gln Cys Cys Ser Ala Val Ile Gln Glu Ile Ser Ala Pro Ile 
    50                  55                  60                  


Ser Thr Val Trp Ser Val Val Arg Arg Phe Asp Asn Pro Gln Ala Tyr 
65                  70                  75                  80  


Lys His Phe Leu Lys Ser Cys Ser Val Ile Gly Gly Asp Gly Asp Asn 
                85                  90                  95      


Val Gly Ser Leu Arg Gln Val His Val Val Ser Gly Leu Pro Ala Ala 
            100                 105                 110         


Ser Ser Thr Glu Arg Leu Asp Ile Leu Asp Asp Glu Arg His Val Ile 
        115                 120                 125             


Ser Phe Ser Val Val Gly Gly Asp His Arg Leu Ser Asn Tyr Arg Ser 
    130                 135                 140                 


Val Thr Thr Leu His Pro Ser Pro Ile Ser Gly Thr Val Val Val Glu 
145                 150                 155                 160 


Ser Tyr Val Val Asp Val Pro Pro Gly Asn Thr Lys Glu Glu Thr Cys 
                165                 170                 175     


Asp Phe Val Asp Val Ile Val Arg Cys Asn Leu Gln Ser Leu Ala Lys 
            180                 185                 190         


Ile Ala Glu Asn Thr Ala Ala Glu Ser Lys Lys Lys Met Ser Leu 
        195                 200                 205         


<210>  84
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  84

Met Arg Ser Pro Val Gln Leu Gln His Gly Ser Asp Ala Thr Asn Gly 
1               5                   10                  15      


Phe His Thr Leu Gln Pro His Asp Gln Thr Asp Gly Pro Ile Lys Arg 
            20                  25                  30          


Val Cys Leu Thr Arg Gly Met His Val Pro Glu His Val Ala Met His 
        35                  40                  45              


His Thr His Asp Val Gly Pro Asp Gln Cys Cys Ser Ser Val Val Gln 
    50                  55                  60                  


Met Ile His Ala Pro Pro Glu Ser Val Trp Ala Leu Val Arg Arg Phe 
65                  70                  75                  80  


Asp Asn Pro Lys Val Tyr Lys Asn Phe Ile Arg Gln Cys Arg Ile Val 
                85                  90                  95      


Gln Gly Asp Gly Leu His Val Gly Asp Leu Arg Glu Val Met Val Val 
            100                 105                 110         


Ser Gly Leu Pro Ala Val Ser Ser Thr Glu Arg Leu Glu Ile Leu Asp 
        115                 120                 125             


Glu Glu Arg His Val Ile Ser Phe Ser Val Val Gly Gly Asp His Arg 
    130                 135                 140                 


Leu Lys Asn Tyr Arg Ser Val Thr Thr Leu His Ala Ser Asp Asp Glu 
145                 150                 155                 160 


Gly Thr Val Val Val Glu Ser Tyr Ile Val Asp Val Pro Pro Gly Asn 
                165                 170                 175     


Thr Glu Glu Glu Thr Leu Ser Phe Val Asp Thr Ile Val Arg Cys Asn 
            180                 185                 190         


Leu Gln Ser Leu Ala Arg Ser Thr Asn Arg Gln 
        195                 200             


<210>  85
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  85

Met Pro Thr Ser Ile Gln Phe Gln Arg Ser Ser Thr Ala Ala Glu Ala 
1               5                   10                  15      


Ala Asn Ala Thr Val Arg Asn Tyr Pro His His His Gln Lys Gln Val 
            20                  25                  30          


Gln Lys Val Ser Leu Thr Arg Gly Met Ala Asp Val Pro Glu His Val 
        35                  40                  45              


Glu Leu Ser His Thr His Val Val Gly Pro Ser Gln Cys Phe Ser Val 
    50                  55                  60                  


Val Val Gln Asp Val Glu Ala Pro Val Ser Thr Val Trp Ser Ile Leu 
65                  70                  75                  80  


Ser Arg Phe Glu His Pro Gln Ala Tyr Lys His Phe Val Lys Ser Cys 
                85                  90                  95      


His Val Val Ile Gly Asp Gly Arg Glu Val Gly Ser Val Arg Glu Val 
            100                 105                 110         


Arg Val Val Ser Gly Leu Pro Ala Ala Phe Ser Leu Glu Arg Leu Glu 
        115                 120                 125             


Ile Met Asp Asp Asp Arg His Val Ile Ser Phe Ser Val Val Gly Gly 
    130                 135                 140                 


Asp His Arg Leu Met Asn Tyr Lys Ser Val Thr Thr Val His Glu Ser 
145                 150                 155                 160 


Glu Glu Asp Ser Asp Gly Lys Lys Arg Thr Arg Val Val Glu Ser Tyr 
                165                 170                 175     


Val Val Asp Val Pro Ala Gly Asn Asp Lys Glu Glu Thr Cys Ser Phe 
            180                 185                 190         


Ala Asp Thr Ile Val Arg Cys Asn Leu Gln Ser Leu Ala Lys Leu Ala 
        195                 200                 205             


Glu Asn Thr Ser Lys Phe Ser 
    210                 215 


<210>  86
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  86

Met Glu Met Ile Gly Gly Asp Asp Thr Asp Thr Glu Met Tyr Gly Ala 
1               5                   10                  15      


Leu Val Thr Ala Gln Ser Leu Arg Leu Arg His Leu His His Cys Arg 
            20                  25                  30          


Glu Asn Gln Cys Thr Ser Val Leu Val Lys Tyr Ile Gln Ala Pro Val 
        35                  40                  45              


His Leu Val Trp Ser Leu Val Arg Arg Phe Asp Gln Pro Gln Lys Tyr 
    50                  55                  60                  


Lys Pro Phe Ile Ser Arg Cys Thr Val Asn Gly Asp Pro Glu Ile Gly 
65                  70                  75                  80  


Cys Leu Arg Glu Val Asn Val Lys Ser Gly Leu Pro Ala Thr Thr Ser 
                85                  90                  95      


Thr Glu Arg Leu Glu Gln Leu Asp Asp Glu Glu His Ile Leu Gly Ile 
            100                 105                 110         


Asn Ile Ile Gly Gly Asp His Arg Leu Lys Asn Tyr Ser Ser Ile Leu 
        115                 120                 125             


Thr Val His Pro Glu Met Ile Asp Gly Arg Ser Gly Thr Met Val Met 
    130                 135                 140                 


Glu Ser Phe Val Val Asp Val Pro Gln Gly Asn Thr Lys Asp Asp Thr 
145                 150                 155                 160 


Cys Tyr Phe Val Glu Ser Leu Ile Lys Cys Asn Leu Lys Ser Leu Ala 
                165                 170                 175     


Cys Val Ser Glu Arg Leu Ala Ala Gln Asp Ile Thr Asn Ser Ile Ala 
            180                 185                 190         


Thr Phe Cys Asn Ala Ser Asn Gly Tyr Arg Glu Lys Asn His Thr Glu 
        195                 200                 205             


Thr Asn Leu 
    210     


<210>  87
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  87

Met Glu Ala Asn Gly Ile Glu Asn Leu Thr Asn Pro Asn Gln Glu Arg 
1               5                   10                  15      


Glu Phe Ile Arg Arg His His Lys His Glu Leu Val Asp Asn Gln Cys 
            20                  25                  30          


Ser Ser Thr Leu Val Lys His Ile Asn Ala Pro Val His Ile Val Trp 
        35                  40                  45              


Ser Leu Val Arg Arg Phe Asp Gln Pro Gln Lys Tyr Lys Pro Phe Ile 
    50                  55                  60                  


Ser Arg Cys Val Val Lys Gly Asn Met Glu Ile Gly Thr Val Arg Glu 
65                  70                  75                  80  


Val Asp Val Lys Ser Gly Leu Pro Ala Thr Arg Ser Thr Glu Arg Leu 
                85                  90                  95      


Glu Leu Leu Asp Asp Asn Glu His Ile Leu Ser Ile Arg Ile Val Gly 
            100                 105                 110         


Gly Asp His Arg Leu Lys Asn Tyr Ser Ser Ile Ile Ser Leu His Pro 
        115                 120                 125             


Glu Thr Ile Glu Gly Arg Ile Gly Thr Leu Val Ile Glu Ser Phe Val 
    130                 135                 140                 


Val Asp Val Pro Glu Gly Asn Thr Lys Asp Glu Thr Cys Tyr Phe Val 
145                 150                 155                 160 


Glu Ala Leu Ile Lys Cys Asn Leu Lys Ser Leu Ala Asp Ile Ser Glu 
                165                 170                 175     


Arg Leu Ala Val Gln Asp Thr Thr Glu Ser Arg Val 
            180                 185             


<210>  88
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  88

Met Met Asp Gly Val Glu Gly Gly Thr Ala Met Tyr Gly Gly Leu Glu 
1               5                   10                  15      


Thr Val Gln Tyr Val Arg Thr His His Gln His Leu Cys Arg Glu Asn 
            20                  25                  30          


Gln Cys Thr Ser Ala Leu Val Lys His Ile Lys Ala Pro Leu His Leu 
        35                  40                  45              


Val Trp Ser Leu Val Arg Arg Phe Asp Gln Pro Gln Lys Tyr Lys Pro 
    50                  55                  60                  


Phe Val Ser Arg Cys Thr Val Ile Gly Asp Pro Glu Ile Gly Ser Leu 
65                  70                  75                  80  


Arg Glu Val Asn Val Lys Ser Gly Leu Pro Ala Thr Thr Ser Thr Glu 
                85                  90                  95      


Arg Leu Glu Leu Leu Asp Asp Glu Glu His Ile Leu Gly Ile Lys Ile 
            100                 105                 110         


Ile Gly Gly Asp His Arg Leu Lys Asn Tyr Ser Ser Ile Leu Thr Val 
        115                 120                 125             


His Pro Glu Ile Ile Glu Gly Arg Ala Gly Thr Met Val Ile Glu Ser 
    130                 135                 140                 


Phe Val Val Asp Val Pro Gln Gly Asn Thr Lys Asp Glu Thr Cys Tyr 
145                 150                 155                 160 


Phe Val Glu Ala Leu Ile Arg Cys Asn Leu Lys Ser Leu Ala Asp Val 
                165                 170                 175     


Ser Glu Arg Leu Ala Ser Gln Asp Ile Thr Gln 
            180                 185         


<210>  89
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  89

Met Pro Ser Glu Leu Thr Pro Glu Glu Arg Ser Glu Leu Lys Asn Ser 
1               5                   10                  15      


Ile Ala Glu Phe His Thr Tyr Gln Leu Asp Pro Gly Ser Cys Ser Ser 
            20                  25                  30          


Leu His Ala Gln Arg Ile His Ala Pro Pro Glu Leu Val Trp Ser Ile 
        35                  40                  45              


Val Arg Arg Phe Asp Lys Pro Gln Thr Tyr Lys His Phe Ile Lys Ser 
    50                  55                  60                  


Cys Ser Val Glu Gln Asn Phe Glu Met Arg Val Gly Cys Thr Arg Asp 
65                  70                  75                  80  


Val Ile Val Ile Ser Gly Leu Pro Ala Asn Thr Ser Thr Glu Arg Leu 
                85                  90                  95      


Asp Ile Leu Asp Asp Glu Arg Arg Val Thr Gly Phe Ser Ile Ile Gly 
            100                 105                 110         


Gly Glu His Arg Leu Thr Asn Tyr Lys Ser Val Thr Thr Val His Arg 
        115                 120                 125             


Phe Glu Lys Glu Asn Arg Ile Trp Thr Val Val Leu Glu Ser Tyr Val 
    130                 135                 140                 


Val Asp Met Pro Glu Gly Asn Ser Glu Asp Asp Thr Arg Met Phe Ala 
145                 150                 155                 160 


Asp Thr Val Val Lys Leu Asn Leu Gln Lys Leu Ala Thr Val Ala Glu 
                165                 170                 175     


Ala Met Ala Arg Asn Ser Gly Asp Gly Ser Gly Ser Gln Val Thr 
            180                 185                 190     


<210>  90
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  90

Met Glu Glu Val Ser Pro Ala Ile Ala Gly Pro Phe Arg Pro Phe Ser 
1               5                   10                  15      


Glu Thr Gln Met Asp Phe Thr Gly Ile Arg Leu Gly Lys Gly Tyr Cys 
            20                  25                  30          


Asn Asn Gln Tyr Ser Asn Gln Asp Ser Glu Asn Gly Asp Leu Met Val 
        35                  40                  45              


Ser Leu Pro Glu Thr Ser Ser Cys Ser Val Ser Gly Ser His Gly Ser 
    50                  55                  60                  


Glu Ser Arg Lys Val Leu Ile Ser Arg Ile Asn Ser Pro Asn Leu Asn 
65                  70                  75                  80  


Met Lys Glu Ser Ala Ala Ala Asp Ile Val Val Val Asp Ile Ser Ala 
                85                  90                  95      


Gly Asp Glu Ile Asn Gly Ser Asp Ile Thr Ser Glu Lys Lys Met Ile 
            100                 105                 110         


Ser Arg Thr Glu Ser Arg Ser Leu Phe Glu Phe Lys Ser Val Pro Leu 
        115                 120                 125             


Tyr Gly Phe Thr Ser Ile Cys Gly Arg Arg Pro Glu Met Glu Asp Ala 
    130                 135                 140                 


Val Ser Thr Ile Pro Arg Phe Leu Gln Ser Ser Ser Gly Ser Met Leu 
145                 150                 155                 160 


Asp Gly Arg Phe Asp Pro Gln Ser Ala Ala His Phe Phe Gly Val Tyr 
                165                 170                 175     


Asp Gly His Gly Gly Ser Gln Val Ala Asn Tyr Cys Arg Glu Arg Met 
            180                 185                 190         


His Leu Ala Leu Ala Glu Glu Ile Ala Lys Glu Lys Pro Met Leu Cys 
        195                 200                 205             


Asp Gly Asp Thr Trp Leu Glu Lys Trp Lys Lys Ala Leu Phe Asn Ser 
    210                 215                 220                 


Phe Leu Arg Val Asp Ser Glu Ile Glu Ser Val Ala Pro Glu Thr Val 
225                 230                 235                 240 


Gly Ser Thr Ser Val Val Ala Val Val Phe Pro Ser His Ile Phe Val 
                245                 250                 255     


Ala Asn Cys Gly Asp Ser Arg Ala Val Leu Cys Arg Gly Lys Thr Ala 
            260                 265                 270         


Leu Pro Leu Ser Val Asp His Lys Pro Asp Arg Glu Asp Glu Ala Ala 
        275                 280                 285             


Arg Ile Glu Ala Ala Gly Gly Lys Val Ile Gln Trp Asn Gly Ala Arg 
    290                 295                 300                 


Val Phe Gly Val Leu Ala Met Ser Arg Ser Ile Gly Asp Arg Tyr Leu 
305                 310                 315                 320 


Lys Pro Ser Ile Ile Pro Asp Pro Glu Val Thr Ala Val Lys Arg Val 
                325                 330                 335     


Lys Glu Asp Asp Cys Leu Ile Leu Ala Ser Asp Gly Val Trp Asp Val 
            340                 345                 350         


Met Thr Asp Glu Glu Ala Cys Glu Met Ala Arg Lys Arg Ile Leu Leu 
        355                 360                 365             


Trp His Lys Lys Asn Ala Val Ala Gly Asp Ala Ser Leu Leu Ala Asp 
    370                 375                 380                 


Glu Arg Arg Lys Glu Gly Lys Asp Pro Ala Ala Met Ser Ala Ala Glu 
385                 390                 395                 400 


Tyr Leu Ser Lys Leu Ala Ile Gln Arg Gly Ser Lys Asp Asn Ile Ser 
                405                 410                 415     


Val Val Val Val Asp Leu Lys Pro Arg Arg Lys Leu Lys Ser Lys Pro 
            420                 425                 430         


Leu Asn 
        


<210>  91
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  91

Met Asp Glu Val Ser Pro Ala Val Ala Val Pro Phe Arg Pro Phe Thr 
1               5                   10                  15      


Asp Pro His Ala Gly Leu Arg Gly Tyr Cys Asn Gly Glu Ser Arg Val 
            20                  25                  30          


Thr Leu Pro Glu Ser Ser Cys Ser Gly Asp Gly Ala Met Lys Asp Ser 
        35                  40                  45              


Ser Phe Glu Ile Asn Thr Arg Gln Asp Ser Leu Thr Ser Ser Ser Ser 
    50                  55                  60                  


Ala Met Ala Gly Val Asp Ile Ser Ala Gly Asp Glu Ile Asn Gly Ser 
65                  70                  75                  80  


Asp Glu Phe Asp Pro Arg Ser Met Asn Gln Ser Glu Lys Lys Val Leu 
                85                  90                  95      


Ser Arg Thr Glu Ser Arg Ser Leu Phe Glu Phe Lys Cys Val Pro Leu 
            100                 105                 110         


Tyr Gly Val Thr Ser Ile Cys Gly Arg Arg Pro Glu Met Glu Asp Ser 
        115                 120                 125             


Val Ser Thr Ile Pro Arg Phe Leu Gln Val Ser Ser Ser Ser Leu Leu 
    130                 135                 140                 


Asp Gly Arg Val Thr Asn Gly Phe Asn Pro His Leu Ser Ala His Phe 
145                 150                 155                 160 


Phe Gly Val Tyr Asp Gly His Gly Gly Ser Gln Val Ala Asn Tyr Cys 
                165                 170                 175     


Arg Glu Arg Met His Leu Ala Leu Thr Glu Glu Ile Val Lys Glu Lys 
            180                 185                 190         


Pro Glu Phe Cys Asp Gly Asp Thr Trp Gln Glu Lys Trp Lys Lys Ala 
        195                 200                 205             


Leu Phe Asn Ser Phe Met Arg Val Asp Ser Glu Ile Glu Thr Val Ala 
    210                 215                 220                 


His Ala Pro Glu Thr Val Gly Ser Thr Ser Val Val Ala Val Val Phe 
225                 230                 235                 240 


Pro Thr His Ile Phe Val Ala Asn Cys Gly Asp Ser Arg Ala Val Leu 
                245                 250                 255     


Cys Arg Gly Lys Thr Pro Leu Ala Leu Ser Val Asp His Lys Pro Asp 
            260                 265                 270         


Arg Asp Asp Glu Ala Ala Arg Ile Glu Ala Ala Gly Gly Lys Val Ile 
        275                 280                 285             


Arg Trp Asn Gly Ala Arg Val Phe Gly Val Leu Ala Met Ser Arg Ser 
    290                 295                 300                 


Ile Gly Asp Arg Tyr Leu Lys Pro Ser Val Ile Pro Asp Pro Glu Val 
305                 310                 315                 320 


Thr Ser Val Arg Arg Val Lys Glu Asp Asp Cys Leu Ile Leu Ala Ser 
                325                 330                 335     


Asp Gly Leu Trp Asp Val Met Thr Asn Glu Glu Val Cys Asp Leu Ala 
            340                 345                 350         


Arg Lys Arg Ile Leu Leu Trp His Lys Lys Asn Ala Met Ala Gly Glu 
        355                 360                 365             


Ala Leu Leu Pro Ala Glu Lys Arg Gly Glu Gly Lys Asp Pro Ala Ala 
    370                 375                 380                 


Met Ser Ala Ala Glu Tyr Leu Ser Lys Met Ala Leu Gln Lys Gly Ser 
385                 390                 395                 400 


Lys Asp Asn Ile Ser Val Val Val Val Asp Leu Lys Gly Ile Arg Lys 
                405                 410                 415     


Phe Lys Ser Lys Ser Leu Asn 
            420             


<210>  92
<211>  612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  92

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Glu Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Pro Asp Glu Ile Val Ala Asp Ser Phe Glu Ala Leu Gly Ala 
            500                 505                 510         


Asn Thr Ile Lys Glu Pro Gly Leu Cys Pro Ser Val Ser Ser Asn Asp 
        515                 520                 525             


Gln Gln Val Pro Ser Ala Val Arg Tyr Asn Gly Ser Lys Arg Val Lys 
    530                 535                 540                 


Pro Glu Glu Glu Glu Glu Arg Asp Met Lys Lys Ser Arg Gly Phe Asp 
545                 550                 555                 560 


Glu Arg Glu Leu Phe Ser Thr Ala Glu Ser Ser Ser Ser Ser Ser Val 
                565                 570                 575     


Phe Phe Val Ser Gln Ser Cys Ser Leu Ala Ser Glu Gly Lys Asn Leu 
            580                 585                 590         


Glu Gly Ile Gln Asp Ser Ser Asp Gln Ile Thr Thr Ser Leu Gly Lys 
        595                 600                 605             


Asn Gly Cys Lys 
    610         


<210>  93
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  93

Met Asn Gly Ala Ile Gly Gly Asp Leu Leu Leu Asn Phe Pro Asp Met 
1               5                   10                  15      


Ser Val Leu Glu Arg Gln Arg Ala His Leu Lys Tyr Leu Asn Pro Thr 
            20                  25                  30          


Phe Asp Ser Pro Leu Ala Gly Phe Phe Ala Asp Ser Ser Met Ile Thr 
        35                  40                  45              


Gly Gly Glu Met Asp Ser Tyr Leu Ser Thr Ala Gly Leu Asn Leu Pro 
    50                  55                  60                  


Met Met Tyr Gly Glu Thr Thr Val Glu Gly Asp Ser Arg Leu Ser Ile 
65                  70                  75                  80  


Ser Pro Glu Thr Thr Leu Gly Thr Gly Asn Phe Lys Lys Arg Lys Phe 
                85                  90                  95      


Asp Thr Glu Thr Lys Asp Cys Asn Glu Lys Lys Lys Lys Met Thr Met 
            100                 105                 110         


Asn Arg Asp Asp Leu Val Glu Glu Gly Glu Glu Glu Lys Ser Lys Ile 
        115                 120                 125             


Thr Glu Gln Asn Asn Gly Ser Thr Lys Ser Ile Lys Lys Met Lys His 
    130                 135                 140                 


Lys Ala Lys Lys Glu Glu Asn Asn Phe Ser Asn Asp Ser Ser Lys Val 
145                 150                 155                 160 


Thr Lys Glu Leu Glu Lys Thr Asp Tyr Ile His Val Arg Ala Arg Arg 
                165                 170                 175     


Gly Gln Ala Thr Asp Ser His Ser Ile Ala Glu Arg Val Arg Arg Glu 
            180                 185                 190         


Lys Ile Ser Glu Arg Met Lys Phe Leu Gln Asp Leu Val Pro Gly Cys 
        195                 200                 205             


Asp Lys Ile Thr Gly Lys Ala Gly Met Leu Asp Glu Ile Ile Asn Tyr 
    210                 215                 220                 


Val Gln Ser Leu Gln Arg Gln Ile Glu Phe Leu Ser Met Lys Leu Ala 
225                 230                 235                 240 


Ile Val Asn Pro Arg Pro Asp Phe Asp Met Asp Asp Ile Phe Ala Lys 
                245                 250                 255     


Glu Val Ala Ser Thr Pro Met Thr Val Val Pro Ser Pro Glu Met Val 
            260                 265                 270         


Leu Ser Gly Tyr Ser His Glu Met Val His Ser Gly Tyr Ser Ser Glu 
        275                 280                 285             


Met Val Asn Ser Gly Tyr Leu His Val Asn Pro Met Gln Gln Val Asn 
    290                 295                 300                 


Thr Ser Ser Asp Pro Leu Ser Cys Phe Asn Asn Gly Glu Ala Pro Ser 
305                 310                 315                 320 


Met Trp Asp Ser His Val Gln Asn Leu Tyr Gly Asn Leu Gly Val 
                325                 330                 335 


<210>  94
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  94

Met Lys Arg Asp His His His His His His Gln Asp Lys Lys Thr Met 
1               5                   10                  15      


Met Met Asn Glu Glu Asp Asp Gly Asn Gly Met Asp Glu Leu Leu Ala 
            20                  25                  30          


Val Leu Gly Tyr Lys Val Arg Ser Ser Glu Met Ala Asp Val Ala Gln 
        35                  40                  45              


Lys Leu Glu Gln Leu Glu Val Met Met Ser Asn Val Gln Glu Asp Asp 
    50                  55                  60                  


Leu Ser Gln Leu Ala Thr Glu Thr Val His Tyr Asn Pro Ala Glu Leu 
65                  70                  75                  80  


Tyr Thr Trp Leu Asp Ser Met Leu Thr Asp Leu Asn Pro Pro Ser Ser 
                85                  90                  95      


Asn Ala Glu Tyr Asp Leu Lys Ala Ile Pro Gly Asp Ala Ile Leu Asn 
            100                 105                 110         


Gln Phe Ala Ile Asp Ser Ala Ser Ser Ser Asn Gln Gly Gly Gly Gly 
        115                 120                 125             


Asp Thr Tyr Thr Thr Asn Lys Arg Leu Lys Cys Ser Asn Gly Val Val 
    130                 135                 140                 


Glu Thr Thr Thr Ala Thr Ala Glu Ser Thr Arg His Val Val Leu Val 
145                 150                 155                 160 


Asp Ser Gln Glu Asn Gly Val Arg Leu Val His Ala Leu Leu Ala Cys 
                165                 170                 175     


Ala Glu Ala Val Gln Lys Glu Asn Leu Thr Val Ala Glu Ala Leu Val 
            180                 185                 190         


Lys Gln Ile Gly Phe Leu Ala Val Ser Gln Ile Gly Ala Met Arg Lys 
        195                 200                 205             


Val Ala Thr Tyr Phe Ala Glu Ala Leu Ala Arg Arg Ile Tyr Arg Leu 
    210                 215                 220                 


Ser Pro Ser Gln Ser Pro Ile Asp His Ser Leu Ser Asp Thr Leu Gln 
225                 230                 235                 240 


Met His Phe Tyr Glu Thr Cys Pro Tyr Leu Lys Phe Ala His Phe Thr 
                245                 250                 255     


Ala Asn Gln Ala Ile Leu Glu Ala Phe Gln Gly Lys Lys Arg Val His 
            260                 265                 270         


Val Ile Asp Phe Ser Met Ser Gln Gly Leu Gln Trp Pro Ala Leu Met 
        275                 280                 285             


Gln Ala Leu Ala Leu Arg Pro Gly Gly Pro Pro Val Phe Arg Leu Thr 
    290                 295                 300                 


Gly Ile Gly Pro Pro Ala Pro Asp Asn Phe Asp Tyr Leu His Glu Val 
305                 310                 315                 320 


Gly Cys Lys Leu Ala His Leu Ala Glu Ala Ile His Val Glu Phe Glu 
                325                 330                 335     


Tyr Arg Gly Phe Val Ala Asn Thr Leu Ala Asp Leu Asp Ala Ser Met 
            340                 345                 350         


Leu Glu Leu Arg Pro Ser Glu Ile Glu Ser Val Ala Val Asn Ser Val 
        355                 360                 365             


Phe Glu Leu His Lys Leu Leu Gly Arg Pro Gly Ala Ile Asp Lys Val 
    370                 375                 380                 


Leu Gly Val Val Asn Gln Ile Lys Pro Glu Ile Phe Thr Val Val Glu 
385                 390                 395                 400 


Gln Glu Ser Asn His Asn Ser Pro Ile Phe Leu Asp Arg Phe Thr Glu 
                405                 410                 415     


Ser Leu His Tyr Tyr Ser Thr Leu Phe Asp Ser Leu Glu Gly Val Pro 
            420                 425                 430         


Ser Gly Gln Asp Lys Val Met Ser Glu Val Tyr Leu Gly Lys Gln Ile 
        435                 440                 445             


Cys Asn Val Val Ala Cys Asp Gly Pro Asp Arg Val Glu Arg His Glu 
    450                 455                 460                 


Thr Leu Ser Gln Trp Arg Asn Arg Phe Gly Ser Ala Gly Phe Ala Ala 
465                 470                 475                 480 


Ala His Ile Gly Ser Asn Ala Phe Lys Gln Ala Ser Met Leu Leu Ala 
                485                 490                 495     


Leu Phe Asn Gly Gly Glu Gly Tyr Arg Val Glu Glu Ser Asp Gly Cys 
            500                 505                 510         


Leu Met Leu Gly Trp His Thr Arg Pro Leu Ile Ala Thr Ser Ala Trp 
        515                 520                 525             


Lys Leu Ser Thr Asn 
    530             


<210>  95
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  95

Met Ala Ala Ser Asp Glu Val Asn Leu Ile Glu Ser Arg Thr Val Val 
1               5                   10                  15      


Pro Leu Asn Thr Trp Val Leu Ile Ser Asn Phe Lys Val Ala Tyr Asn 
            20                  25                  30          


Ile Leu Arg Arg Pro Asp Gly Thr Phe Asn Arg His Leu Ala Glu Tyr 
        35                  40                  45              


Leu Asp Arg Lys Val Thr Ala Asn Ala Asn Pro Val Asp Gly Val Phe 
    50                  55                  60                  


Ser Phe Asp Val Leu Ile Asp Arg Arg Ile Asn Leu Leu Ser Arg Val 
65                  70                  75                  80  


Tyr Arg Pro Ala Tyr Ala Asp Gln Glu Gln Pro Pro Ser Ile Leu Asp 
                85                  90                  95      


Leu Glu Lys Pro Val Asp Gly Asp Ile Val Pro Val Ile Leu Phe Phe 
            100                 105                 110         


His Gly Gly Ser Phe Ala His Ser Ser Ala Asn Ser Ala Ile Tyr Asp 
        115                 120                 125             


Thr Leu Cys Arg Arg Leu Val Gly Leu Cys Lys Cys Val Val Val Ser 
    130                 135                 140                 


Val Asn Tyr Arg Arg Ala Pro Glu Asn Pro Tyr Pro Cys Ala Tyr Asp 
145                 150                 155                 160 


Asp Gly Trp Ile Ala Leu Asn Trp Val Asn Ser Arg Ser Trp Leu Lys 
                165                 170                 175     


Ser Lys Lys Asp Ser Lys Val His Ile Phe Leu Ala Gly Asp Ser Ser 
            180                 185                 190         


Gly Gly Asn Ile Ala His Asn Val Ala Leu Arg Ala Gly Glu Ser Gly 
        195                 200                 205             


Ile Asp Val Leu Gly Asn Ile Leu Leu Asn Pro Met Phe Gly Gly Asn 
    210                 215                 220                 


Glu Arg Thr Glu Ser Glu Lys Ser Leu Asp Gly Lys Tyr Phe Val Thr 
225                 230                 235                 240 


Val Arg Asp Arg Asp Trp Tyr Trp Lys Ala Phe Leu Pro Glu Gly Glu 
                245                 250                 255     


Asp Arg Glu His Pro Ala Cys Asn Pro Phe Ser Pro Arg Gly Lys Ser 
            260                 265                 270         


Leu Glu Gly Val Ser Phe Pro Lys Ser Leu Val Val Val Ala Gly Leu 
        275                 280                 285             


Asp Leu Ile Arg Asp Trp Gln Leu Ala Tyr Ala Glu Gly Leu Lys Lys 
    290                 295                 300                 


Ala Gly Gln Glu Val Lys Leu Met His Leu Glu Lys Ala Thr Val Gly 
305                 310                 315                 320 


Phe Tyr Leu Leu Pro Asn Asn Asn His Phe His Asn Val Met Asp Glu 
                325                 330                 335     


Ile Ser Ala Phe Val Asn Ala Glu Cys 
            340                 345 


<210>  96
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  96

Met Ala Gly Gly Asn Glu Val Asn Leu Asn Glu Cys Lys Arg Ile Val 
1               5                   10                  15      


Pro Leu Asn Thr Trp Val Leu Ile Ser Asn Phe Lys Leu Ala Tyr Lys 
            20                  25                  30          


Val Leu Arg Arg Pro Asp Gly Ser Phe Asn Arg Asp Leu Ala Glu Phe 
        35                  40                  45              


Leu Asp Arg Lys Val Pro Ala Asn Ser Phe Pro Leu Asp Gly Val Phe 
    50                  55                  60                  


Ser Phe Asp His Val Asp Ser Thr Thr Asn Leu Leu Thr Arg Ile Tyr 
65                  70                  75                  80  


Gln Pro Ala Ser Leu Leu His Gln Thr Arg His Gly Thr Leu Glu Leu 
                85                  90                  95      


Thr Lys Pro Leu Ser Thr Thr Glu Ile Val Pro Val Leu Ile Phe Phe 
            100                 105                 110         


His Gly Gly Ser Phe Thr His Ser Ser Ala Asn Ser Ala Ile Tyr Asp 
        115                 120                 125             


Thr Phe Cys Arg Arg Leu Val Thr Ile Cys Gly Val Val Val Val Ser 
    130                 135                 140                 


Val Asp Tyr Arg Arg Ser Pro Glu His Arg Tyr Pro Cys Ala Tyr Asp 
145                 150                 155                 160 


Asp Gly Trp Asn Ala Leu Asn Trp Val Lys Ser Arg Val Trp Leu Gln 
                165                 170                 175     


Ser Gly Lys Asp Ser Asn Val Tyr Val Tyr Leu Ala Gly Asp Ser Ser 
            180                 185                 190         


Gly Gly Asn Ile Ala His Asn Val Ala Val Arg Ala Thr Asn Glu Gly 
        195                 200                 205             


Val Lys Val Leu Gly Asn Ile Leu Leu His Pro Met Phe Gly Gly Gln 
    210                 215                 220                 


Glu Arg Thr Gln Ser Glu Lys Thr Leu Asp Gly Lys Tyr Phe Val Thr 
225                 230                 235                 240 


Ile Gln Asp Arg Asp Trp Tyr Trp Arg Ala Tyr Leu Pro Glu Gly Glu 
                245                 250                 255     


Asp Arg Asp His Pro Ala Cys Asn Pro Phe Gly Pro Arg Gly Gln Ser 
            260                 265                 270         


Leu Lys Gly Val Asn Phe Pro Lys Ser Leu Val Val Val Ala Gly Leu 
        275                 280                 285             


Asp Leu Val Gln Asp Trp Gln Leu Ala Tyr Val Asp Gly Leu Lys Lys 
    290                 295                 300                 


Thr Gly Leu Glu Val Asn Leu Leu Tyr Leu Lys Gln Ala Thr Ile Gly 
305                 310                 315                 320 


Phe Tyr Phe Leu Pro Asn Asn Asp His Phe His Cys Leu Met Glu Glu 
                325                 330                 335     


Leu Asn Lys Phe Val His Ser Ile Glu Asp Ser Gln Ser Lys Ser Ser 
            340                 345                 350         


Pro Val Leu Leu Thr Pro 
        355             


<210>  97
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  97

Met Ala Gly Ser Glu Glu Val Asn Leu Ile Glu Ser Lys Thr Val Val 
1               5                   10                  15      


Pro Leu Asn Thr Trp Val Leu Ile Ser Asn Phe Lys Leu Ala Tyr Asn 
            20                  25                  30          


Leu Leu Arg Arg Pro Asp Gly Thr Phe Asn Arg His Leu Ala Glu Phe 
        35                  40                  45              


Leu Asp Arg Lys Val Pro Ala Asn Ala Asn Pro Val Asn Gly Val Phe 
    50                  55                  60                  


Ser Phe Asp Val Ile Ile Asp Arg Gln Thr Asn Leu Leu Ser Arg Val 
65                  70                  75                  80  


Tyr Arg Pro Ala Asp Ala Gly Thr Ser Pro Ser Ile Thr Asp Leu Gln 
                85                  90                  95      


Asn Pro Val Asp Gly Glu Ile Val Pro Val Ile Val Phe Phe His Gly 
            100                 105                 110         


Gly Ser Phe Ala His Ser Ser Ala Asn Ser Ala Ile Tyr Asp Thr Leu 
        115                 120                 125             


Cys Arg Arg Leu Val Gly Leu Cys Gly Ala Val Val Val Ser Val Asn 
    130                 135                 140                 


Tyr Arg Arg Ala Pro Glu Asn Arg Tyr Pro Cys Ala Tyr Asp Asp Gly 
145                 150                 155                 160 


Trp Ala Val Leu Lys Trp Val Asn Ser Ser Ser Trp Leu Arg Ser Lys 
                165                 170                 175     


Lys Asp Ser Lys Val Arg Ile Phe Leu Ala Gly Asp Ser Ser Gly Gly 
            180                 185                 190         


Asn Ile Val His Asn Val Ala Val Arg Ala Val Glu Ser Arg Ile Asp 
        195                 200                 205             


Val Leu Gly Asn Ile Leu Leu Asn Pro Met Phe Gly Gly Thr Glu Arg 
    210                 215                 220                 


Thr Glu Ser Glu Lys Arg Leu Asp Gly Lys Tyr Phe Val Thr Val Arg 
225                 230                 235                 240 


Asp Arg Asp Trp Tyr Trp Arg Ala Phe Leu Pro Glu Gly Glu Asp Arg 
                245                 250                 255     


Glu His Pro Ala Cys Ser Pro Phe Gly Pro Arg Ser Lys Ser Leu Glu 
            260                 265                 270         


Gly Leu Ser Phe Pro Lys Ser Leu Val Val Val Ala Gly Leu Asp Leu 
        275                 280                 285             


Ile Gln Asp Trp Gln Leu Lys Tyr Ala Glu Gly Leu Lys Lys Ala Gly 
    290                 295                 300                 


Gln Glu Val Lys Leu Leu Tyr Leu Glu Gln Ala Thr Ile Gly Phe Tyr 
305                 310                 315                 320 


Leu Leu Pro Asn Asn Asn His Phe His Thr Val Met Asp Glu Ile Ala 
                325                 330                 335     


Ala Phe Val Asn Ala Glu Cys Gln 
            340                 


<210>  98
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  98

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg 
65                  70                  75                  80  


Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly 
                85                  90                  95      


Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr 
            100                 105                 110         


Lys 
    


<210>  99
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  99

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Thr Arg Lys 
65                  70                  75                  80  


Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln 
                85                  90                  95      


Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr Lys 
            100                 105                 110         


<210>  100
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  100

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Asp Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu 
            20                  25                  30          


Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu 
        35                  40                  45              


Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala 
    50                  55                  60                  


Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr 
65                  70                  75                  80  


Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr 
                85                  90                  95      


Gln Arg Pro Tyr Tyr Lys 
            100         


<210>  101
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  101

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Asp Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu 
            20                  25                  30          


Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu 
        35                  40                  45              


Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala 
    50                  55                  60                  


Glu Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln 
65                  70                  75                  80  


Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln 
                85                  90                  95      


Arg Pro Tyr Tyr Lys 
            100     


<210>  102
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  102

Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser 
1               5                   10                  15      


Asp Leu Asn Thr Gln 
            20      


<210>  103
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  103

Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
    50                  55                  60                  


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
65                  70                  75                  80  


His Glu Lys Pro Pro Gln 
                85      


<210>  104
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  104

Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu 
1               5                   10                  15      


Thr Leu Lys His Glu 
            20      


<210>  105
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  105

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  106
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  106

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Thr Ala Asp Thr Gln 
                85                  90                  95      


Ala Leu Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp 
            100                 105                 110         


Asp Ala Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
        115                 120                 125         


<210>  107
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  107

Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr Ser 
1               5                   10                  15      


His Leu Gly Gly Asn 
            20      


<210>  108
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  108

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  109
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  109

Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
1               5                   10                  15      


Gly Leu Asn Gln Arg 
            20      


<210>  110
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  110

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  111
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  111

Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser 
1               5                   10                  15      


His Leu Gln Gly Asn 
            20      


<210>  112
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  112

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210>  113
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  113

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  114
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  114

Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
1               5                   10                  15      


Val Leu Asp Lys Arg 
            20      


<210>  115
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  115

Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
1               5                   10                  15      


Ser Glu Ile Gly Met Lys 
            20          


<210>  116
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  116

Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
1               5                   10                  15      


Ala Leu His Met Gln 
            20      


<210>  117
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  117

Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Gly Thr Leu Ile Ile Gln Asn Val 
                85                  90                  95      


Asn Lys Ser His Gly Gly Ile Tyr Val Cys Arg Val Gln Glu Gly Asn 
            100                 105                 110         


Glu Ser Tyr Gln Gln Ser Cys Gly Thr Tyr Leu Arg Val Arg Gln Pro 
        115                 120                 125             


Pro Pro Arg Pro Phe Leu Asp Met Gly Glu Gly Thr Lys Asn Arg Ile 
    130                 135                 140                 


Ile Thr Ala Glu Gly Ile Ile Leu Leu Phe Cys Ala Val Val Pro Gly 
145                 150                 155                 160 


Thr Leu Leu Leu Phe Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu 
                165                 170                 175     


Asp Ala Gly Asp Glu Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn 
            180                 185                 190         


Leu Asp Asp Cys Ser Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly 
        195                 200                 205             


Thr Tyr Gln Asp Val Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu 
    210                 215                 220                 


Lys Pro 
225     


<210>  118
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  118

Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Glu Pro Pro Pro Arg Pro Phe Leu 
                85                  90                  95      


Asp Met Gly Glu Gly Thr Lys Asn Arg Ile Ile Thr Ala Glu Gly Ile 
            100                 105                 110         


Ile Leu Leu Phe Cys Ala Val Val Pro Gly Thr Leu Leu Leu Phe Arg 
        115                 120                 125             


Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu Asp Ala Gly Asp Glu Tyr 
    130                 135                 140                 


Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys Ser Met 
145                 150                 155                 160 


Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly Thr Tyr Gln Asp Val Gly 
                165                 170                 175     


Ser Leu Asn Ile Gly Asp Val Gln Leu Glu Lys Pro 
            180                 185             


<210>  119
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  119

Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys Ser Met Tyr Glu 
1               5                   10                  15      


Asp Ile Ser Arg Gly 
            20      


<210>  120
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  120

Arg Pro Arg Arg Ser Pro Ala Gln Asp Gly Lys Val Tyr Ile Asn Met 
1               5                   10                  15      


Pro Gly Arg Gly 
            20  


<210>  121
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  121

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210>  122
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  122

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  123
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  123

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  124
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  124

His His His His His 
1               5   


<210>  125
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  125

His His His His His His 
1               5       


<210>  126
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  126

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  127
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  127

Arg Tyr Ile Arg Ser 
1               5   


<210>  128
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  128

Phe His His Thr 
1               


<210>  129
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  129

Trp Glu Ala Ala Ala Arg Glu Ala Cys Cys Arg Glu Cys Cys Ala Arg 
1               5                   10                  15      


Ala 
    


<210>  130
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  the amino acids in these positions can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  the amino acids in this position can be either Leu or Ile

<400>  130

Tyr Xaa Xaa Xaa 
1               


<210>  131
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  the amino acids in these positions can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  the amino acids in this positions can be either Leu or Ile

<220>
<221>  MISC_FEATURE
<222>  (5)..(10)
<223>  the amino acids in these positions can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(12)
<223>  the amino acids in these positions may be present or absent such 
       that either one or two amino acids are present.  the amino acids 
       in these positions can be any amino acid

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  the amino acids in this positions can be either Leu or Ile

<400>  131

Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa 
1               5                   10                  15      


<210>  132
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  132
gattacaagg atgacgatga caag                                              24


<210>  133
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  133

Gly Gly Ala Thr Cys Cys Cys Ala Gly Gly Thr Ala Cys Ala Ala Cys 
1               5                   10                  15      


Thr Gly Cys Ala Gly Cys Ala Gly Thr Cys Thr Gly Gly Gly Cys Cys 
            20                  25                  30          


Thr Gly Ala Gly Cys Thr Gly Gly Ala Gly Ala Ala Gly Cys Cys Thr 
        35                  40                  45              


Gly Gly Cys Gly Cys Thr Thr Cys Ala Gly Thr Gly Ala Ala Gly Ala 
    50                  55                  60                  


Thr Ala Thr Cys Cys Thr Gly Cys Ala Ala Gly Gly Cys Thr Thr Cys 
65                  70                  75                  80  


Thr Gly Gly Thr Thr Ala Cys Thr Cys Ala Thr Thr Cys Ala Cys Thr 
                85                  90                  95      


Gly Gly Cys Thr Ala Cys Ala Cys Cys Ala Thr Gly Ala Ala Cys Thr 
            100                 105                 110         


Gly Gly Gly Thr Gly Ala Ala Gly Cys Ala Gly Ala Gly Cys Cys Ala 
        115                 120                 125             


Thr Gly Gly Ala Ala Ala Gly Ala Gly Cys Cys Thr Thr Gly Ala Gly 
    130                 135                 140                 


Thr Gly Gly Ala Thr Thr Gly Gly Ala Cys Thr Thr Ala Thr Thr Ala 
145                 150                 155                 160 


Cys Thr Cys Cys Thr Thr Ala Cys Ala Ala Thr Gly Gly Thr Gly Cys 
                165                 170                 175     


Thr Thr Cys Thr Ala Gly Cys Thr Ala Cys Ala Ala Cys Cys Ala Gly 
            180                 185                 190         


Ala Ala Gly Thr Thr Cys Ala Gly Gly Gly Gly Cys Ala Ala Gly Gly 
        195                 200                 205             


Cys Cys Ala Cys Ala Thr Thr Ala Ala Cys Thr Gly Thr Ala Gly Ala 
    210                 215                 220                 


Cys Ala Ala Gly Thr Cys Ala Thr Cys Cys Ala Gly Cys Ala Cys Ala 
225                 230                 235                 240 


Gly Cys Cys Thr Ala Cys Ala Thr Gly Gly Ala Cys Cys Thr Cys Cys 
                245                 250                 255     


Thr Cys Ala Gly Thr Cys Thr Gly Ala Cys Ala Thr Cys Thr Gly Ala 
            260                 265                 270         


Ala Gly Ala Cys Thr Cys Thr Gly Cys Ala Gly Thr Cys Thr Ala Thr 
        275                 280                 285             


Thr Thr Cys Thr Gly Thr Gly Cys Ala Ala Gly Gly Gly Gly Gly Gly 
    290                 295                 300                 


Gly Thr Thr Ala Cys Gly Ala Cys Gly Gly Gly Ala Gly Gly Gly Gly 
305                 310                 315                 320 


Thr Thr Thr Thr Gly Ala Cys Thr Ala Cys Thr Gly Gly Gly Gly Cys 
                325                 330                 335     


Cys Ala Ala Gly Gly Gly Ala Cys Cys Ala Cys Gly Gly Thr Cys Ala 
            340                 345                 350         


Cys Cys Gly Thr Cys Thr Cys Cys Thr Cys Ala Gly Gly Thr Gly Gly 
        355                 360                 365             


Ala Gly Gly Cys Gly Gly Thr Thr Cys Ala Gly Gly Cys Gly Gly Cys 
    370                 375                 380                 


Gly Gly Thr Gly Gly Cys Thr Cys Thr Ala Gly Cys Gly Gly Thr Gly 
385                 390                 395                 400 


Gly Cys Gly Gly Ala Thr Cys Gly Gly Ala Cys Ala Thr Cys Gly Ala 
                405                 410                 415     


Gly Cys Thr Cys Ala Cys Thr Cys Ala Gly Thr Cys Thr Cys Cys Ala 
            420                 425                 430         


Gly Cys Ala Ala Thr Cys Ala Thr Gly Thr Cys Thr Gly Cys Ala Thr 
        435                 440                 445             


Cys Thr Cys Cys Ala Gly Gly Gly Gly Ala Gly Ala Ala Gly Gly Thr 
    450                 455                 460                 


Cys Ala Cys Cys Ala Thr Gly Ala Cys Cys Thr Gly Cys Ala Gly Thr 
465                 470                 475                 480 


Gly Cys Cys Ala Gly Cys Thr Cys Ala Ala Gly Thr Gly Thr Ala Ala 
                485                 490                 495     


Gly Thr Thr Ala Cys Ala Thr Gly Cys Ala Cys Thr Gly Gly Thr Ala 
            500                 505                 510         


Cys Cys Ala Gly Cys Ala Gly Ala Ala Gly Thr Cys Ala Gly Gly Cys 
        515                 520                 525             


Ala Cys Cys Thr Cys Cys Cys Cys Cys Ala Ala Ala Ala Gly Ala Thr 
    530                 535                 540                 


Gly Gly Ala Thr Thr Thr Ala Thr Gly Ala Cys Ala Cys Ala Thr Cys 
545                 550                 555                 560 


Cys Ala Ala Ala Cys Thr Gly Gly Cys Thr Thr Cys Thr Gly Gly Ala 
                565                 570                 575     


Gly Thr Cys Cys Cys Ala Gly Gly Thr Cys Gly Cys Thr Thr Cys Ala 
            580                 585                 590         


Gly Thr Gly Gly Cys Ala Gly Thr Gly Gly Gly Thr Cys Thr Gly Gly 
        595                 600                 605             


Ala Ala Ala Cys Thr Cys Thr Thr Ala Cys Thr Cys Thr Cys Thr Cys 
    610                 615                 620                 


Ala Cys Ala Ala Thr Cys Ala Gly Cys Ala Gly Cys Gly Thr Gly Gly 
625                 630                 635                 640 


Ala Gly Gly Cys Thr Gly Ala Ala Gly Ala Thr Gly Ala Thr Gly Cys 
                645                 650                 655     


Ala Ala Cys Thr Thr Ala Thr Thr Ala Cys Thr Gly Cys Cys Ala Gly 
            660                 665                 670         


Cys Ala Gly Thr Gly Gly Ala Gly Thr Ala Ala Gly Cys Ala Cys Cys 
        675                 680                 685             


Cys Thr Cys Thr Cys Ala Cys Gly Thr Ala Cys Gly Gly Thr Gly Cys 
    690                 695                 700                 


Thr Gly Gly Gly Ala Cys Ala Ala Ala Gly Thr Thr Gly Gly Ala Ala 
705                 710                 715                 720 


Ala Thr Cys Ala Ala Ala Gly Cys Thr Ala Gly Cys 
                725                 730         


<210>  134
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  134

Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr 
            20                  25                  30          


Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu 
        35                  40                  45              


Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln 
    50                  55                  60                  


Lys Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Ser Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly 
                165                 170                 175     


Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Ser Lys His Pro Leu Thr Tyr Gly Ala Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Ala Ser 
                


<210>  135
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  135
ggatcccagg tgcagctgca ggaatctggc cctggcctcg tgaagcccag cgagacactg       60

agcctgacct gtaccgtgtc tggcggctct gtgtccagcg gcagctacta ctggtcctgg      120

atcagacagc cccctggcaa gggcctggaa tggatcggct acatctacta cagcggctcc      180

accaactaca accccagcct gaagtccaga gtgaccatca gcgtggacac cagcaagaac      240

cagttctccc tgaagctgag cagcgtgaca gccgccgata ccgccgtgta ctactgtgcc      300

agagagggca agaacggcgc cttcgacatc tggggccagg gcacaatggt caccgtgtca      360

tctggtggag gaggatctgg gggaggcgga agcggaggcg gcggatctga tattcagatg      420

acccagagcc ccagcagcct gagcgcctct gtgggcgaca gagtgacaat tacctgccgg      480

gccagccaga gcatcagcag ctacctgaac tggtatcagc agaagcccgg caaggccccc      540

aaactgctga tctacgccgc cagctctctg cagtctggcg tgcccagcag attttccggc      600

tctggcagcg gcaccgactt caccctgacc atctctagcc tgcagcccga ggacttcgcc      660

acctactact gccagcagag ctacagcacc cccctgacct ttggcggagg caccaaggtg      720

gaaatcaag                                                              729


<210>  136
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  136

Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
1               5                   10                  15      


Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser 
            20                  25                  30          


Ser Gly Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly 
        35                  40                  45              


Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn 
    50                  55                  60                  


Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Gly Lys Asn Gly Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  137
<211>  1044
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  137
atggctgcga gcgatgaagt taatcttatt gagagcagaa cagtggttcc tctcaataca       60

tgggttttaa tatccaactt caaagtagcc tacaatatcc ttcgtcgccc tgatggaacc      120

tttaaccgac acttagctga gtatctagac cgtaaagtca ctgcaaacgc caatccggtt      180

gatggggttt tctcgttcga tgtcttgatt gatcgcagga tcaatcttct aagcagagtc      240

tatagaccag cttatgcaga tcaagagcaa cctcctagta ttttagatct cgagaagcct      300

gttgatggcg acattgtccc tgttatattg ttcttccatg gaggtagctt tgctcattct      360

tctgcaaaca gtgccatcta cgatactctt tgtcgcaggc ttgttggttt gtgcaagtgt      420

gttgttgtct ctgtgaatta tcggcgtgca ccagagaatc catacccttg tgcttatgat      480

gatggttgga ttgctcttaa ttgggttaac tcgagatctt ggcttaaatc caagaaagac      540

tcaaaggtcc atattttctt ggctggtgat agctctggag gtaacatcgc gcataatgtg      600

gctttaagag cgggtgaatc gggaatcgat gttttgggga acattctgct gaatcctatg      660

tttggtggga atgagagaac ggagtctgag aaaagtttgg atgggaaata ctttgtgacg      720

gttagagacc gcgattggta ctggaaagcg tttttacccg agggagaaga tagagagcat      780

ccagcgtgta atccgtttag cccgagaggg aaaagcttag aaggagtgag tttccccaag      840

agtcttgtgg ttgtcgcggg tttggatttg attagagatt ggcagttggc atacgcggaa      900

gggctcaaga aagcgggtca agaggttaag cttatgcatt tagagaaagc aactgttggg      960

ttttacctct tgcctaataa caatcatttc cataatgtta tggatgagat ttcggcgttt     1020

gtaaacgcgg aatgtatgcg tgac                                            1044


<210>  138
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  138

Met Ala Ala Ser Asp Glu Val Asn Leu Ile Glu Ser Arg Thr Val Val 
1               5                   10                  15      


Pro Leu Asn Thr Trp Val Leu Ile Ser Asn Phe Lys Val Ala Tyr Asn 
            20                  25                  30          


Ile Leu Arg Arg Pro Asp Gly Thr Phe Asn Arg His Leu Ala Glu Tyr 
        35                  40                  45              


Leu Asp Arg Lys Val Thr Ala Asn Ala Asn Pro Val Asp Gly Val Phe 
    50                  55                  60                  


Ser Phe Asp Val Leu Ile Asp Arg Arg Ile Asn Leu Leu Ser Arg Val 
65                  70                  75                  80  


Tyr Arg Pro Ala Tyr Ala Asp Gln Glu Gln Pro Pro Ser Ile Leu Asp 
                85                  90                  95      


Leu Glu Lys Pro Val Asp Gly Asp Ile Val Pro Val Ile Leu Phe Phe 
            100                 105                 110         


His Gly Gly Ser Phe Ala His Ser Ser Ala Asn Ser Ala Ile Tyr Asp 
        115                 120                 125             


Thr Leu Cys Arg Arg Leu Val Gly Leu Cys Lys Cys Val Val Val Ser 
    130                 135                 140                 


Val Asn Tyr Arg Arg Ala Pro Glu Asn Pro Tyr Pro Cys Ala Tyr Asp 
145                 150                 155                 160 


Asp Gly Trp Ile Ala Leu Asn Trp Val Asn Ser Arg Ser Trp Leu Lys 
                165                 170                 175     


Ser Lys Lys Asp Ser Lys Val His Ile Phe Leu Ala Gly Asp Ser Ser 
            180                 185                 190         


Gly Gly Asn Ile Ala His Asn Val Ala Leu Arg Ala Gly Glu Ser Gly 
        195                 200                 205             


Ile Asp Val Leu Gly Asn Ile Leu Leu Asn Pro Met Phe Gly Gly Asn 
    210                 215                 220                 


Glu Arg Thr Glu Ser Glu Lys Ser Leu Asp Gly Lys Tyr Phe Val Thr 
225                 230                 235                 240 


Val Arg Asp Arg Asp Trp Tyr Trp Lys Ala Phe Leu Pro Glu Gly Glu 
                245                 250                 255     


Asp Arg Glu His Pro Ala Cys Asn Pro Phe Ser Pro Arg Gly Lys Ser 
            260                 265                 270         


Leu Glu Gly Val Ser Phe Pro Lys Ser Leu Val Val Val Ala Gly Leu 
        275                 280                 285             


Asp Leu Ile Arg Asp Trp Gln Leu Ala Tyr Ala Glu Gly Leu Lys Lys 
    290                 295                 300                 


Ala Gly Gln Glu Val Lys Leu Met His Leu Glu Lys Ala Thr Val Gly 
305                 310                 315                 320 


Phe Tyr Leu Leu Pro Asn Asn Asn His Phe His Asn Val Met Asp Glu 
                325                 330                 335     


Ile Ser Ala Phe Val Asn Ala Glu Cys Met Arg Asp 
            340                 345             


<210>  139
<211>  276
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  139
atgaagagag atcatcatca tcatcatcat caagataaga agactatgat gatgaatgaa       60

gaagacgacg gtaacggcat ggatgagctt ctagctgttc ttggttacaa ggttaggtca      120

tccgaaatgg ctgatgttgc tcagaaactc gagcagcttg aagttatgat gtctaatgtt      180

caagaagacg atctttctca actcgctact gagactgttc actataatcc ggcggagctt      240

tacacgtggc ttgattctat gctcaccgac cttaat                                276


<210>  140
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  140

Met Lys Arg Asp His His His His His His Gln Asp Lys Lys Thr Met 
1               5                   10                  15      


Met Met Asn Glu Glu Asp Asp Gly Asn Gly Met Asp Glu Leu Leu Ala 
            20                  25                  30          


Val Leu Gly Tyr Lys Val Arg Ser Ser Glu Met Ala Asp Val Ala Gln 
        35                  40                  45              


Lys Leu Glu Gln Leu Glu Val Met Met Ser Asn Val Gln Glu Asp Asp 
    50                  55                  60                  


Leu Ser Gln Leu Ala Thr Glu Thr Val His Tyr Asn Pro Ala Glu Leu 
65                  70                  75                  80  


Tyr Thr Trp Leu Asp Ser Met Leu Thr Asp Leu Asn 
                85                  90          


<210>  141
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  141
ggatcccagg tgcagctggt gcagtctggc gccgaagtga aaagaccagg cgccagcgtg       60

caggtctcct gtagagccag cggctacagc atcaacacct actacatgca gtgggtgcgc      120

caggccccag gcgctggact ggaatggatg ggcgtgatca accccagcgg cgtgacaagc      180

tacgcccaga aattccaggg cagagtgacc ctgaccaacg acaccagcac caacacagtg      240

tacatgcagc tgaacagcct gaccagcgcc gacaccgccg tgtactactg tgccagatgg      300

gccctgtggg gcgacttcgg catggatgtg tggggcaagg gcaccctcgt gaccgtgtct      360

agcggaggcg gaggatctgg cggaggggga tctggaggcg gcggaagcga catccagatg      420

acccagagcc ctagcaccct gagcgccagc atcggcgata gagtgaccat cacctgtcgg      480

gccagcgagg gcatctatca ctggctggcc tggtatcagc agaagcccgg caaggccccc      540

aagctgctga tctacaaggc cagctctctg gcctctggcg cccctagcag attttctggc      600

agcggctccg gcaccgactt caccctgaca atcagcagcc tgcagcccga cgacttcgcc      660

acctactatt gccagcagta cagcaactac cccctgacct tcggcggagg caccaagctg      720

gaaatcaag                                                              729


<210>  142
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  142

Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro 
1               5                   10                  15      


Gly Ala Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser Ile Asn 
            20                  25                  30          


Thr Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn Thr Val 
65                  70                  75                  80  


Tyr Met Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser 
            180                 185                 190         


Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  143
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  143
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  144
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  144
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg      120

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca      180

cgcgacttcg cagcctatcg ctcc                                             204


<210>  145
<211>  111
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  145
cggagggacc agaggctgcc ccccgatgcc cacaagcccc ctgggggagg cagtttccgg       60

acccccatcc aagaggagca ggccgacgcc cactccaccc tggccaagat c               111


