                         SEQUENCE LISTING

<110>  The United States of America, as represented by the 
       Secretary, Department of Health and Human Services
       Colosi, Peter
       Sieving, Paul Albert
       Zeng, Yong
       Bush, Ronald Avery
 
<120>  METHODS AND COMPOSITIONS FOR TREATING GENETICALLY LINKED DISEASES
        OF THE EYE

<130>  6137NEI-1-PCT

<140>  not yet assigned
<141>  2014-02-13

<150>  61/765,654
<151>  2013-02-15

<150>  61/815,636
<151>  2013-04-24

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  675
<212>  DNA
<213>  Homo sapien

<400>  1
atgtcacgca agatagaagg ctttttgtta ttacttctct ttggctatga agccacattg       60

ggattatcgt ctaccgagga tgaaggcgag gacccctggt accaaaaagc atgcaagtgc      120

gattgccaag gaggacccaa tgctctgtgg tctgcaggtg ccacctcctt ggactgtata      180

ccagaatgcc catatcacaa gcctctgggt ttcgagtcag gggaggtcac accggaccag      240

atcacctgct ctaacccgga gcagtatgtg ggctggtatt cttcgtggac tgcaaacaag      300

gcccggctca acagtcaagg ctttgggtgt gcctggctct ccaagttcca ggacagtagc      360

cagtggttac agatagatct gaaggagatc aaagtgattt cagggatcct cacccagggg      420

cgctgtgaca tcgatgagtg gatgaccaag tacagcgtgc agtacaggac cgatgagcgc      480

ctgaactgga tttactacaa ggaccagact ggaaacaacc gggtcttcta tggcaactcg      540

gaccgcacct ccacggttca gaacctgctg cggcccccca tcatctcccg cttcatccgc      600

ctcatcccgc tgggctggca cgtccgcatt gccatccgga tggagctgct ggagtgcgtc      660

agcaagtgtg cctga                                                       675


<210>  2
<211>  224
<212>  PRT
<213>  Homo sapien

<400>  2

Met Ser Arg Lys Ile Glu Gly Phe Leu Leu Leu Leu Leu Phe Gly Tyr 
1               5                   10                  15      


Glu Ala Thr Leu Gly Leu Ser Ser Thr Glu Asp Glu Gly Glu Asp Pro 
            20                  25                  30          


Trp Tyr Gln Lys Ala Cys Lys Cys Asp Cys Gln Gly Gly Pro Asn Ala 
        35                  40                  45              


Leu Trp Ser Ala Gly Ala Thr Ser Leu Asp Cys Ile Pro Glu Cys Pro 
    50                  55                  60                  


Tyr His Lys Pro Leu Gly Phe Glu Ser Gly Glu Val Thr Pro Asp Gln 
65                  70                  75                  80  


Ile Thr Cys Ser Asn Pro Glu Gln Tyr Val Gly Trp Tyr Ser Ser Trp 
                85                  90                  95      


Thr Ala Asn Lys Ala Arg Leu Asn Ser Gln Gly Phe Gly Cys Ala Trp 
            100                 105                 110         


Leu Ser Lys Phe Gln Asp Ser Ser Gln Trp Leu Gln Ile Asp Leu Lys 
        115                 120                 125             


Glu Ile Lys Val Ile Ser Gly Ile Leu Thr Gln Gly Arg Cys Asp Ile 
    130                 135                 140                 


Asp Glu Trp Met Thr Lys Tyr Ser Val Gln Tyr Arg Thr Asp Glu Arg 
145                 150                 155                 160 


Leu Asn Trp Ile Tyr Tyr Lys Asp Gln Thr Gly Asn Asn Arg Val Phe 
                165                 170                 175     


Tyr Gly Asn Ser Asp Arg Thr Ser Thr Val Gln Asn Leu Leu Arg Pro 
            180                 185                 190         


Pro Ile Ile Ser Arg Phe Ile Arg Leu Ile Pro Leu Gly Trp His Val 
        195                 200                 205             


Arg Ile Ala Ile Arg Met Glu Leu Leu Glu Cys Val Ser Lys Cys Ala 
    210                 215                 220                 


<210>  3
<211>  675
<212>  DNA
<213>  Homo sapien

<400>  3
tcaggcacac ttgctgacgc actccagcag ctccatccgg atggcaatgc ggacgtgcca       60

gcccagcggg atgaggcgga tgaagcggga gatgatgggg ggccgcagca ggttctgaac      120

cgtggaggtg cggtccgagt tgccatagaa gacccggttg tttccagtct ggtccttgta      180

gtaaatccag ttcaggcgct catcggtcct gtactgcacg ctgtacttgg tcatccactc      240

atcgatgtca cagcgcccct gggtgaggat ccctgaaatc actttgatct ccttcagatc      300

tatctgtaac cactggctac tgtcctggaa cttggagagc caggcacacc caaagccttg      360

actgttgagc cgggccttgt ttgcagtcca cgaagaatac cagcccacat actgctccgg      420

gttagagcag gtgatctggt ccggtgtgac ctcccctgac tcgaaaccca gaggcttgtg      480

atatgggcat tctggtatac agtccaagga ggtggcacct gcagaccaca gagcattggg      540

tcctccttgg caatcgcact tgcatgcttt ttggtaccag gggtcctcgc cttcatcctc      600

ggtagacgat aatcccaatg tggcttcata gccaaagaga agtaataaca aaaagccttc      660

tatcttgcgt gacat                                                       675


<210>  4
<211>  606
<212>  DNA
<213>  Homo sapien

<400>  4
tctaccgagg atgaaggcga ggacccctgg taccaaaaag catgcaagtg cgattgccaa       60

ggaggaccca atgctctgtg gtctgcaggt gccacctcct tggactgtat accagaatgc      120

ccatatcaca agcctctggg tttcgagtca ggggaggtca caccggacca gatcacctgc      180

tctaacccgg agcagtatgt gggctggtat tcttcgtgga ctgcaaacaa ggcccggctc      240

aacagtcaag gctttgggtg tgcctggctc tccaagttcc aggacagtag ccagtggtta      300

cagatagatc tgaaggagat caaagtgatt tcagggatcc tcacccaggg gcgctgtgac      360

atcgatgagt ggatgaccaa gtacagcgtg cagtacagga ccgatgagcg cctgaactgg      420

atttactaca aggaccagac tggaaacaac cgggtcttct atggcaactc ggaccgcacc      480

tccacggttc agaacctgct gcggcccccc atcatctccc gcttcatccg cctcatcccg      540

ctgggctggc acgtccgcat tgccatccgg atggagctgc tggagtgcgt cagcaagtgt      600

gcctga                                                                 606


<210>  5
<211>  201
<212>  PRT
<213>  Homo sapien

<400>  5

Ser Thr Glu Asp Glu Gly Glu Asp Pro Trp Tyr Gln Lys Ala Cys Lys 
1               5                   10                  15      


Cys Asp Cys Gln Gly Gly Pro Asn Ala Leu Trp Ser Ala Gly Ala Thr 
            20                  25                  30          


Ser Leu Asp Cys Ile Pro Glu Cys Pro Tyr His Lys Pro Leu Gly Phe 
        35                  40                  45              


Glu Ser Gly Glu Val Thr Pro Asp Gln Ile Thr Cys Ser Asn Pro Glu 
    50                  55                  60                  


Gln Tyr Val Gly Trp Tyr Ser Ser Trp Thr Ala Asn Lys Ala Arg Leu 
65                  70                  75                  80  


Asn Ser Gln Gly Phe Gly Cys Ala Trp Leu Ser Lys Phe Gln Asp Ser 
                85                  90                  95      


Ser Gln Trp Leu Gln Ile Asp Leu Lys Glu Ile Lys Val Ile Ser Gly 
            100                 105                 110         


Ile Leu Thr Gln Gly Arg Cys Asp Ile Asp Glu Trp Met Thr Lys Tyr 
        115                 120                 125             


Ser Val Gln Tyr Arg Thr Asp Glu Arg Leu Asn Trp Ile Tyr Tyr Lys 
    130                 135                 140                 


Asp Gln Thr Gly Asn Asn Arg Val Phe Tyr Gly Asn Ser Asp Arg Thr 
145                 150                 155                 160 


Ser Thr Val Gln Asn Leu Leu Arg Pro Pro Ile Ile Ser Arg Phe Ile 
                165                 170                 175     


Arg Leu Ile Pro Leu Gly Trp His Val Arg Ile Ala Ile Arg Met Glu 
            180                 185                 190         


Leu Leu Glu Cys Val Ser Lys Cys Ala 
        195                 200     


<210>  6
<211>  606
<212>  DNA
<213>  Homo sapien

<400>  6
tcaggcacac ttgctgacgc actccagcag ctccatccgg atggcaatgc ggacgtgcca       60

gcccagcggg atgaggcgga tgaagcggga gatgatgggg ggccgcagca ggttctgaac      120

cgtggaggtg cggtccgagt tgccatagaa gacccggttg tttccagtct ggtccttgta      180

gtaaatccag ttcaggcgct catcggtcct gtactgcacg ctgtacttgg tcatccactc      240

atcgatgtca cagcgcccct gggtgaggat ccctgaaatc actttgatct ccttcagatc      300

tatctgtaac cactggctac tgtcctggaa cttggagagc caggcacacc caaagccttg      360

actgttgagc cgggccttgt ttgcagtcca cgaagaatac cagcccacat actgctccgg      420

gttagagcag gtgatctggt ccggtgtgac ctcccctgac tcgaaaccca gaggcttgtg      480

atatgggcat tctggtatac agtccaagga ggtggcacct gcagaccaca gagcattggg      540

tcctccttgg caatcgcact tgcatgcttt ttggtaccag gggtcctcgc cttcatcctc      600

ggtaga                                                                 606


<210>  7
<211>  489
<212>  DNA
<213>  Homo sapien

<400>  7
tgcccatatc acaagcctct gggtttcgag tcaggggagg tcacaccgga ccagatcacc       60

tgctctaacc cggagcagta tgtgggctgg tattcttcgt ggactgcaaa caaggcccgg      120

ctcaacagtc aaggctttgg gtgtgcctgg ctctccaagt tccaggacag tagccagtgg      180

ttacagatag atctgaagga gatcaaagtg atttcaggga tcctcaccca ggggcgctgt      240

gacatcgatg agtggatgac caagtacagc gtgcagtaca ggaccgatga gcgcctgaac      300

tggatttact acaaggacca gactggaaac aaccgggtct tctatggcaa ctcggaccgc      360

acctccacgg ttcagaacct gctgcggccc cccatcatct cccgcttcat ccgcctcatc      420

ccgctgggct ggcacgtccg cattgccatc cggatggagc tgctggagtg cgtcagcaag      480

tgtgcctga                                                              489


<210>  8
<211>  162
<212>  PRT
<213>  Homo sapien

<400>  8

Cys Pro Tyr His Lys Pro Leu Gly Phe Glu Ser Gly Glu Val Thr Pro 
1               5                   10                  15      


Asp Gln Ile Thr Cys Ser Asn Pro Glu Gln Tyr Val Gly Trp Tyr Ser 
            20                  25                  30          


Ser Trp Thr Ala Asn Lys Ala Arg Leu Asn Ser Gln Gly Phe Gly Cys 
        35                  40                  45              


Ala Trp Leu Ser Lys Phe Gln Asp Ser Ser Gln Trp Leu Gln Ile Asp 
    50                  55                  60                  


Leu Lys Glu Ile Lys Val Ile Ser Gly Ile Leu Thr Gln Gly Arg Cys 
65                  70                  75                  80  


Asp Ile Asp Glu Trp Met Thr Lys Tyr Ser Val Gln Tyr Arg Thr Asp 
                85                  90                  95      


Glu Arg Leu Asn Trp Ile Tyr Tyr Lys Asp Gln Thr Gly Asn Asn Arg 
            100                 105                 110         


Val Phe Tyr Gly Asn Ser Asp Arg Thr Ser Thr Val Gln Asn Leu Leu 
        115                 120                 125             


Arg Pro Pro Ile Ile Ser Arg Phe Ile Arg Leu Ile Pro Leu Gly Trp 
    130                 135                 140                 


His Val Arg Ile Ala Ile Arg Met Glu Leu Leu Glu Cys Val Ser Lys 
145                 150                 155                 160 


Cys Ala 
        


<210>  9
<211>  1071
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human retinoschisin promoter construct

<400>  9
gcggccgcac caccaaattt agcattttcc tgagtgaata ggtgtgcaca tgatgcctag       60

ttgctttcaa agaggggaat ccatgacatt ttcatacaat tcgagaatgt tagtgcttat      120

gtggcaggaa attgttcaag gtcaccccct aaaaaatgat ggcgaagaaa ggacgaaaac      180

ctgagacttc tggttgtagt tctctccctc cattgcttcc cttacattaa gatagaatga      240

acagtatggt cgacggccca ggcttcccag cagggctaag gatatgcaag gagtgcattc      300

atccggaggt gttggcagca tcccagcccc accccattct catcgtaaat caggctcact      360

tccattggct gcatacggtg gagtgatgtg accatatgtc acttgagcat tacacaaatc      420

ctaatgagct aaaaatatgt ttgttttagc taattgacct ctttggcctt cataaagcag      480

ttggtaaaca tcctcagata atgatttcca aagaggtcga ccgaaaagta tcttcctcgc      540

gaactgaatc tcagttgatg ctagtatctt ccatgagact tccttgttga ggcaggtaac      600

tctgtgggtt aacttgatgg ggctcagcca aagacctaag aactaaatgg attaagatgc      660

ttaatgaggc cagggctcaa cttaatcccc tgctcctggg ccagctctcc agttcagtaa      720

ggtagagctt tggccgagga cgaggggaag atgtcacgca agatagaagg ctttttgtta      780

ttacttctct ttggctatga aggtatgtgc tattcaacca ttgacattca ttgcatactt      840

aatacataat ttaattaata tcgttgataa ataggaatat agcctgaata atataaatat      900

tattaattag caacacgtta attaactaac atgtgttatt aatgaacaac agttgtcttt      960

gtgtggatgg ctttccagtt ctgtgaggag ccttctaaag ttcaaaggat gcttaaaatc     1020

caacagaaaa caggatgggt ctcagaaatc tataaaatag ccagcgatcg c              1071


<210>  10
<211>  245
<212>  DNA
<213>  Homo sapien

<400>  10
aagatagaag gctttttgtt attacttctc tttggctatg aagccacatt gggattatcg       60

tctaccgagg atgaaggcga ggacccctgg taccaaaaag catgcaagtg cgattgccaa      120

ggaggaccca atgctctgtg gtctgcaggt gccacctcct tggactgtat accagaatgc      180

ccatatcaca agcctctggg tttcgagtca ggggaggtca caccggacca gatcacctgc      240

tctaa                                                                  245


<210>  11
<211>  229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human retinoschisin promoter sequence (nucleotides 522-750 of SEQ
       ID NO:9)

<400>  11
cgaaaagtat cttcctcgcg aactgaatct cagttgatgc tagtatcttc catgagactt       60

ccttgttgag gcaggtaact ctgtgggtta acttgatggg gctcagccaa agacctaaga      120

actaaatgga ttaagatgct taatgaggcc agggctcaac ttaatcccct gctcctgggc      180

cagctctcca gttcagtaag gtagagcttt ggccgaggac gaggggaag                  229


<210>  12
<211>  261
<212>  DNA
<213>  Homo sapien

<400>  12
ggcccaggct tcccagcagg gctaaggata tgcaaggagt gcattcatcc ggaggtgttg       60

gcagcatccc agccccaccc cattctcatc gtaaatcagg ctcacttcca ttggctgcat      120

acggtggagt gatgtgacca tatgtcactt gagcattaca caaatcctaa tgagctaaaa      180

atatgtttgt tttagctaat tgacctcttt ggccttcata aagcagttgg taaacatcct      240

cagataatga tttccaaaga g                                                261


<210>  13
<211>  2217
<212>  DNA
<213>  Adeno-associated virus

<400>  13
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga      600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac     1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg     1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg     1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg     1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat     1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct     1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac     1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc     1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt     1740

atcgtggcag ataacttgca gcagcaaaac acggctcctc aaattggaac tgtcaacagc     1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccacccgt ctccgctgat gggcggcttt     1920

ggcctgaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct     1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag     2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt taatacagaa     2160

ggcgtgtact ctgaaccccg ccccattggc acccgttacc tcacccgtaa tctgtaa        2217


<210>  14
<211>  738
<212>  PRT
<213>  Adeno-associated virus

<400>  14

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  15
<211>  2217
<212>  DNA
<213>  Homo sapien

<400>  15
ttacagatta cgggtgaggt aacgggtgcc aatggggcgg ggttcagagt acacgccttc       60

tgtattaaca gcaaagtcca cacttgtaga tttgtagtag ttggaggtgt actggatctc      120

ggggttccag cgcttgctgt tttccttctg cagctcccat tcaatttcca cgctgacctg      180

tccggtgctg tattgcgtga tgaaagagtt cagctttgac tggttgaagg tggtcggagg      240

atccgcaggt acaggcgtgt tcttgatcag gatctgaggc ggaggatgtt tcaggccaaa      300

gccgcccatc agcggagacg ggtggaagtt gccgtccgtg tgaggaatct tggcccagat      360

gggaccctgc aggtacacgt cccggttctg ccagaccata ccgggtaagg ccccctggct      420

gttgacagtt ccaatttgag gagccgtgtt ttgctgctgc aagttatctg ccacgatacc      480

gtattcctct gtagccacag ggttagtggt tttgatttct tcctcgctgg tgagcatgac      540

atcgctgtaa tccgcattgt ctctggcagc attttgtttg ccaaaaatca ggatcccgtt      600

actgggaaaa aaacgctcct cgtcgtcttt gtgtgttgcc atagcgatgc caggattagc      660

caatgaattt cttccattca gatggtattt ggtcccagca gtccaggcaa agttgctatt      720

gttgttttgc ccggttgtcg ttgagacgcg ttgttggcgg taacagggtc ctggcagcca      780

gttctttgcc tgattggcca ttgtattagg cccaccttgg ctgaagccca gagtctgcgt      840

atttgccgtg cctcctgttg tttgagtccg agacaagtag tacaggtact ggtcaatcag      900

aggattcatc agccggtcca agctctggct gtgggcgtag ctgctgtgga aaggcacgtc      960

ctcgaaggtg taagtaaact ggaagttgtt gccggttctc agcatctgcg aaggaaagta     1020

ttccaggcag tagaaggagg agcgtcccac ggcctgacta ccgttgttga gtgttaggta     1080

gccgtactgg ggaatcatga acacgtccgc cgggaacgga ggcaggcagc cctggtgggc     1140

agagccgaga acgtacggca gctggtactc cgagtccgta aacacctgga tggtgctggt     1200

gaggttattg gcgatggtct tggtgccttc attctgcgtg acctccttga cctggatgtt     1260

gaagagcttg aagctgagtc tcttgggccg gaatccccag ttgttgttga tgagtcgctg     1320

ccagtcacgt ggtgaaaagt ggcagtggaa tctgttaaag tcaaaatacc cccagggggt     1380

gctgtagccg aagtaggtgt tgtcgttggt ggctcctccc gatgtcccgt tggagatttg     1440

cttgtagagg tggttgttgt aggtgggcag ggcccaggtt cgggtgctgg tggtgatgac     1500

tctgtcgccc agccatgtgg aatcgcaatg ccaatttccc gaggaactac ccactccgtc     1560

ggcgccttcg ttattgtctg ccattggtgc gccaccgcct gcagccattg tattaggtcc     1620

cacaccagag ggcgctgctg gaggttctcc gagaggttga gggtctggaa ctgactctga     1680

gtcgccagtc tgaccaaaat tgagtctttt tctggcgggc tgttggcctt tcttgccgat     1740

gcccgtagag gagtctggag aacgctgggg tgatggctct accggtctct tctttccagg     1800

agccgtctta gcgccttcct caaccagacc gagaggttcg agaacccgct tcttggcctg     1860

gaagactgct cgcccgaggt tgcccccaaa agacgtatct tcttgcagac gctcctgaaa     1920

ctcggcgtcg gcgtggttat accgcaggta cggattgtca cccgcctgca gctgctggtc     1980

gtaggccttg tcgtgctcga gggccgctgc gtccgccgcg ttgacgggct cccccttgtc     2040

gagtccgttg aagggtccga ggtacttgta gccaggaagc accagacccc ggccgtcgtc     2100

ctgcttttgc tggttggctt tgggcttcgg ggctccaggt ttcagcgccc accactcgcg     2160

aatgccctca gagaggttgt cctcgagcca atctggaaga taaccatcgg cagccat        2217


<210>  16
<211>  9504
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full length sequence of pV scRS/IRBP hRS vector

<400>  16
agttaattaa cacagctgcg cgctcgctcg ctcactgagg ccgcccgggc aaagcccggg       60

cgtcgggcga cctttggtcg cccggcctca gtgagcgagc gagcgcgcag agagggagtg      120

ggggggatcc actagttcta gagcggccgc accaccaaat ttagcatttt cctgagtgaa      180

taggtgtgca catgatgcct agttgctttc aaagagggga atccatgaca ttttcataca      240

attcgagaat gttagtgctt atgtggcagg aaattgttca aggtcacccc ctaaaaaatg      300

atggcgaaga aaggacgaaa acctgagact tctggttgta gttctctccc tccattgctt      360

cccttacatt aagatagaat gaacagtatg gtcgacggcc caggcttccc agcagggcta      420

aggatatgca aggagtgcat tcatccggag gtgttggcag catcccagcc ccaccccatt      480

ctcatcgtaa atcaggctca cttccattgg ctgcatacgg tggagtgatg tgaccatatg      540

tcacttgagc attacacaaa tcctaatgag ctaaaaatat gtttgtttta gctaattgac      600

ctctttggcc ttcataaagc agttggtaaa catcctcaga taatgatttc caaagaggtc      660

gaccgaaaag tatcttcctc gcgaactgaa tctcagttga tgctagtatc ttccatgaga      720

cttccttgtt gaggcaggta actctgtggg ttaacttgat ggggctcagc caaagaccta      780

agaactaaat ggattaagat gcttaatgag gccagggctc aacttaatcc cctgctcctg      840

ggccagctct ccagttcagt aaggtagagc tttggccgag gacgagggga agatgtcacg      900

caagatagaa ggctttttgt tattacttct ctttggctat gaaggtatgt gctattcaac      960

cattgacatt cattgcatac ttaatacata atttaattaa tatcgttgat aaataggaat     1020

atagcctgaa taatataaat attattaatt agcaacacgt taattaacta acatgtgtta     1080

ttaatgaaca acagttgtct ttgtgtggat ggctttccag ttctgtgagg agccttctaa     1140

agttcaaagg atgcttaaaa tccaacagaa aacaggatgg gtctcagaaa tctataaaat     1200

agccagcgat cgcgatttct ctttcattaa ttagattttt tctgtctcat ccttttgctt     1260

tagccacatt gggattatcg tctaccgagg atgaaggcga ggacccctgg taccaaaaag     1320

catgcaagtg cgattgccaa ggaggaccca atgctctgtg gtctgcaggt gccacctcct     1380

tggactgtat accagaatgc ccatatcaca agcctctggg tttcgagtca ggggaggtca     1440

caccggacca gatcacctgc tctaacccgg agcagtatgt gggctggtat tcttcgtgga     1500

ctgcaaacaa ggcccggctc aacagtcaag gctttgggtg tgcctggctc tccaagttcc     1560

aggacagtag ccagtggtta cagatagatc tgaaggagat caaagtgatt tcagggatcc     1620

tcacccaggg gcgctgtgac atcgatgagt ggatgaccaa gtacagcgtg cagtacagga     1680

ccgatgagcg cctgaactgg atttactaca aggaccagac tggaaacaac cgggtcttct     1740

atggcaactc ggaccgcacc tccacggttc agaacctgct gcggcccccc atcatctccc     1800

gcttcatccg cctcatcccg ctgggctggc acgtccgcat tgccatccgg atggagctgc     1860

tggagtgcgt cagcaagtgt gcctgactcg agagatctaa tctcgctttc ttgctgtcca     1920

atttctatta aaggttcctt tgttccctaa gtccaactac taaactgggg gatattatga     1980

agggccttga gcatctggat tctgcctaat aaaaaacatt tattttcatt gcaatgatgt     2040

atttaaatta tttctgaata ttttactaaa aagggaatgt gggaggtcag tgcatttaaa     2100

acataaagaa agtagggcgc gccaggaacc cctagtgatg gagttggcca ctccctctct     2160

gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg     2220

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaagg ccggccaagc     2280

ttggcgtaat catggtcata gctgtttcct gtgtgaaatt gttatccgct cacaattcca     2340

cacaacatac gagccggaag cataaagtgt aaagcctggg gtgcctaatg agtgagctaa     2400

ctcacattaa ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag     2460

ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc     2520

gctgtcctgc aggacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc     2580

gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc     2640

tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga     2700

agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt     2760

ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg     2820

taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc     2880

gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg     2940

gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc     3000

ttgaagtggt ggcctaacta cggctacact agaaggacag tatttggtat ctgcgctctg     3060

ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc     3120

gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct     3180

caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt     3240

taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa     3300

aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa     3360

tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc     3420

tgactccccg tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct     3480

gcaatgatac cgcgagaccc acgctcaccg gctccagatt tatcagcaat aaaccagcca     3540

gccggaaggg ccgagcgcag aagtggtcct gcaactttat ccgcctccat ccagtctatt     3600

aattgttgcc gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt     3660

gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc     3720

ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc     3780

tccttcggtc ctccgatcgt tgtcagaagt aagttggccg cagtgttatc actcatggtt     3840

atggcagcac tgcataattc tcttactgtc atgccatccg taagatgctt ttctgtgact     3900

ggtgagtact caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc     3960

ccggcgtcaa tacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt     4020

ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg     4080

atgtaaccca ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct     4140

gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa     4200

tgttgaatac tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt     4260

ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc     4320

acatttcccc gaaaagtgcc acctgacgtc taagaaacca ttattatcat gacattaacc     4380

tataaaaata ggcgtatcac gaggcccttt cgtctcgcgc gtttcggtga tgacggtgaa     4440

aacctctgac acatgcagct cccggagacg gtcacagctt gtctgtaagc ggatgccggg     4500

agcagacaag cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg ctggcttaac     4560

tatgcggcat cagagcagat tgtactgaga gtgcaccata aaattgtaaa cgttaatatt     4620

ttgttaaaat tcgcgttaaa tttttgttaa atcagctcat tttttaacca ataggccgaa     4680

atcggcaaaa tcccttataa atcaaaagaa tagcccgaga tagggttgag tgttgttcca     4740

gtttggaaca agagtccact attaaagaac gtggactcca acgtcaaagg gcgaaaaacc     4800

gtctatcagg gcgatggccc actacgtgaa ccatcaccca aatcaagttt tttggggtcg     4860

aggtgccgta aagcactaaa tcggaaccct aaagggagcc cccgatttag agcttgacgg     4920

ggaaagccgg cgaacgtggc gagaaaggaa gggaagaaag cgaaaggagc gggcgctagg     4980

gcgctggcaa gtgtagcggt cacgctgcgc gtaaccacca cacccgccgc gcttaatgcg     5040

ccgctacagg gcgcgtacta tggttgcttt gacgtatgcg gtgtgaaata ccgcacagat     5100

gcgtaaggag aaaataccgc atcaggccgt aacctgtcgg atcaccggaa aggacccgta     5160

aagtgataat gattatcatc tacatatcac aacgtgcgtg gaggccatca aaccacgtca     5220

aataatcaat tatgacgcag gtatcgtatt aattgatctg catcaactta acgtaaaaac     5280

aacttcagac aatacaaatc agcgacactg aatacggggc aacctcatgt caacgaagaa     5340

cagaacccgc agaacaacaa cccgcaacat ccgctttcct aaccaaatga ttgaacaaat     5400

taacatcgct cttgagcaaa aagggtccgg gaatttctca gcctgggtca ttgaagcctg     5460

ccgtcggaga ctaacgtcag aaaagagagc atatacatca attaaaagtg atgaagaatg     5520

aacatcccgc gttcttccct ccgaacagga cgatattgta aattcactta attacgaggg     5580

cattgcagta attgagttgc agttttacca ctttcctgac agtgacagac tgcgtgttgg     5640

ctctgtcaca gactaaatag tttgaatgat tagcagttat ggtgatcagt caaccaccag     5700

ggaataatcc ttcatattat tatcgtgctt caccaacgct gcctcaattg ctctgaatgc     5760

ttccagagac accttatgtt ctatacatgc aattacaaca tcagggtaac tcatagaaat     5820

ggtgctatta agcatatttt ttacacgaat cagatccacg gagggatcat cagcagattg     5880

ttctttattc attttgtcgc tccatgcgct tgctcttcat ctagcggtta aaatattact     5940

tcaaatcttt ctgtatgaag atttgagcac gttggcctta catacatctg tcggttgtat     6000

ttccctccag aatgccagca ggaccgcact ttgttacgca accaatacta ttaagtgaaa     6060

acattcctaa tatttgacat aaatcatcaa caaaacacaa ggaggtcaga ccagattgaa     6120

acgataaaaa cgataatgca aactacgcgc cctcgtatca catggaaggt tttaccaatg     6180

gctcaggttg ccatttttaa agaaatattc gatcaagtgc gaaaagattt agactgtgaa     6240

ttgttttatt ctgaactaaa acgtcacaac gtctcacatt atatttacta tctagccaca     6300

gataatattc acatcgtgtt agaaaacgat aacaccgtgt taataaaagg acttaaaaag     6360

gttgtaaatg ttaaattctc aagaaacacg catcttatag aaacgtccta tgataggttg     6420

aaatcaagag aaatcacatt tcagcaatac agggaaaatc ttgctaaagc aggagttttc     6480

cgatgggtta caaatatcca tgaacataaa agatattact atacctttga taattcatta     6540

ctatttactg agagcattca gaacactaca caaatctttc cacgctaaat cataacgtcc     6600

ggtttcttcc gtgtcagcac cggggcgttg gcataatgca atacgtgtac gcgctaaacc     6660

ctgtgtgcat cgttttaatt attcccggac actcccgcag agaagttccc cgtcagggct     6720

gtggacatag ttaatccggg aatacaatga cgattcatcg cacctgacat acattaataa     6780

atattaacaa tatgaaattt caactcattg tttagggttt gtttaatttt ctacacatac     6840

gattctgcga acttcaaaaa gcatcgggaa taacaccatg aaaaaaatgc tactcgctac     6900

tgcgctggcc ctgcttatta caggatgtgc tcaacagacg tttactgttc aaaacaaacc     6960

ggcagcagta gcaccaaagg aaaccatcac ccatcatttc ttcgtttctg gaattgggca     7020

gaagaaaact gtcgatgcag ccaaaatttg tggcggcgca gaaaatgttg ttaaaacaga     7080

aacccagcaa acattcgtaa atggattgct cggttttatt actttaggca tttatactcc     7140

gctggaagcg cgtgtgtatt gctcacaata attgcatgag ttgcccatcg atatgggcaa     7200

ctctatctgc actgctcatt aatatacttc tgggttcctt ccagttgttt ttgcatagtg     7260

atcagcctct ctctgagggt gaaataatcc cgttcagcgg tgtctgccag tcggggggag     7320

gctgcattat ccacgccgga ggcggtggtg gcttcacgca ctgactgaca gactgctttg     7380

atgtgcaacc gacgacgacc agcggcaaca tcatcacgca gagcatcatt ttcagcttta     7440

gcatcagcta actccttcgt gtattttgca tcgagcgcag caacatcacg ctgacgcatc     7500

tgcatgtcag taattgccgc gttcgccagc ttcagttctc tggcattttt gtcgcgctgg     7560

gctttgtagg taatggcgtt atcacggtaa tgattaacag cccatgacag gcagacgatg     7620

atgcagataa ccagagcgga gataatcgcg gtgactctgc tcatacatca atctctctga     7680

ccgttccgcc cgcttctttg aattttgcaa tcaggctgtc agccttatgc tcgaactgac     7740

cataaccagc gcccggcagt gaagcccaga tattgctgca acggtcgatt gcctgacgga     7800

tatcaccacg atcaatcata ggtaaagcgc cacgctcctt aatctgctgc aatgccacag     7860

cgtcctgact tttcggagag aagtctttca ggccaagctg cttgcggtag gcatcccacc     7920

aacgggaaag aagctggtag cgtccggcgc ctgttgattt gagttttggg tttagcgtga     7980

caagtttgcg agggtgatcg gagtaatcag taaatagctc tccgcctaca atgacgtcat     8040

aaccatgatt tctggttttc tgacgtccgt tatcagttcc ctccgaccac gccagcatat     8100

cgaggaacgc cttacgttga ttattgattt ctaccatctt ctactccggc ttttttagca     8160

gcgaagcgtt tgataagcga accaatcgag tcagtaccga tgtagccgat aaacacgctc     8220

gttatataag cgagattgct acttagtccg gcgaagtcga gaaggtcacg aatgaaccag     8280

gcgataatgg cgcacatcgt tgcgtcgatt actgtttttg taaacgcacc gccattatat     8340

ctgccgcgaa ggtacgccat tgcaaacgca aggattgccc cgatgccttg ttcctttgcc     8400

gcgagaatgg cggccaacag gtcatgtttt tctggcatct tcatgtctta cccccaataa     8460

ggggatttgc tctatttaat taggaataag gtcgattact gatagaacaa atccaggcta     8520

ctgtgtttag taatcagatt tgttcgtgac cgatatgcac gggcaaaacg gcaggaggtt     8580

gttagcgcga cctcctgcca cccgctttca cgaaggtcat gtgtaaaagg ccgcagcgta     8640

actattacta atgaattcag gacagacagt ggctacggct cagtttgggt tgtgctgttg     8700

ctgggcggcg atgacgcctg tacgcatttg gtgatccggt tctgcttccg gtattcgctt     8760

aattcagcac aacggaaaga gcactggcta accaggctcg ccgactcttc acgattatcg     8820

actcaatgct cttacctgtt gtgcagatat aaaaaatccc gaaaccgtta tgcaggctct     8880

aactattacc tgcgaactgt ttcgggattg cattttgcag acctctctgc ctgcgatggt     8940

tggagttcca gacgatacgt cgaagtgacc aactaggcgg aatcggtagt aagcgccgcc     9000

tcttttcatc tcactaccac aacgagcgaa ttaacccatc gttgagtcaa atttacccaa     9060

ttttattcaa taagtcaata tcatgccgtt aatatgttgc catccgtggc aatcatgctg     9120

ctaacgtgtg accgcattca aaatgttgtc tgcgattgac tcttctttgt ggcattgcac     9180

caccagagcg tcatacagcg gcttaacagt gcgtgaccag gtgggttggg taaggtttgg     9240

gattagcatc gtcacagcgc gatatgctgc gcttgctggc atccttgaat agccgacgcc     9300

tttgcatctt ccgcactctt tctcgacaac tctcccccac agctctgttt tggcaatatc     9360

aaccgcacgg cctgtaccat ggcaatctct gcatcttgcc cccggcgtcg cggcactacg     9420

gcaataatcc gcataagcga atgttgcgag cacttgcagt acctttgcct tagtatttcc     9480

ttcaagctgc ccctgcagga ctcg                                            9504


