                         SEQUENCE LISTING

<110>  SANOFI
       Kruip, Jochen
       Sarkar, Susanta K.
       Gebauer, Mathias
       Lange, Christian
       Focken, Ingo
 
<120>  IMMUNO IMAGING AGENT FOR USE WITH ANTIBODY-DRUG CONJUGATE THERAPY

<130>  12-1363-WO2

<150>  US 61/761,190
<151>  2013-02-05

<150>  EP 14305082.1
<151>  2014-01-21

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  1

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Ser Ala His Ser Ser Val Ser Phe Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Ser Leu Ala Ser Gly Val Pro Ala Arg Phe Gly Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Phe Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Met Ser 
        115                 120                 125             


Ala Ser Pro Gly Glu Arg Val Thr Ile Thr Cys Ser Ala His Ser Ser 
    130                 135                 140                 


Val Ser Phe Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys 
145                 150                 155                 160 


Leu Trp Ile Tyr Ser Thr Ser Ser Leu Ala Ser Gly Val Pro Ala Arg 
                165                 170                 175     


Phe Gly Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser 
            180                 185                 190         


Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser 
        195                 200                 205             


Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr 
    210                 215                 220                 


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
225                 230                 235                 240 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
                245                 250                 255     


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
            260                 265                 270         


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
        275                 280                 285             


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
    290                 295                 300                 


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
305                 310                 315                 320 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                325                 


<210>  2
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  2

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Ser Ala His Ser Ser Val Ser Phe Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Ser Leu Ala Ser Gly Val Pro Ala Arg Phe Gly Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Phe Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  3

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  4
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  4

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  5
<211>  987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  5
gaaatcgtgc tgacccagag ccccgccacc atgtctgcca gccctggcga gagagtcacc       60

atcacctgta gcgcccacag cagcgtcagt ttcatgcact ggttccagca gaagcccggc      120

accagcccaa agctgtggat ctacagcacc agcagcctcg ccagcggcgt cccagctcgc      180

tttggcggca gcggctctgg caccagctac agcctgacca tcagcagcat ggaagccgag      240

gacgccgcca cctactactg ccagcagcgg agcagctttc ccctgacctt cggcgctggc      300

accaagctgg aactgaaggg cggaggcgga tccggcggcg gaggctccga gattgtgctg      360

acacagtctc cagccaccat gagcgcctcc ccaggcgagc gcgtgacaat cacatgctcc      420

gcccactcct ccgtgtcttt tatgcattgg tttcagcaga aacctgggac atcccctaaa      480

ctctggatct actccacctc ctccctggcc tccggggtgc ccgctagatt tggaggctct      540

ggcagcggca cctcctactc cctgaccatc tcctctatgg aagctgaaga tgctgcaaca      600

tattattgcc agcagagaag ctccttccca ctgacatttg gggccggaac aaagctcgag      660

ctgaagcgta cggtggccgc tccttccgtg ttcatcttcc ctccctccga cgagcagctg      720

aagtccggca ccgcctccgt ggtgtgtctg ctgaacaact tctaccctcg ggaggccaag      780

gtgcagtgga aggtggacaa cgccctgcag tccggcaact cccaggagtc cgtcaccgag      840

caggactcca aggacagcac ctactccctg tcctccaccc tgaccctgtc caaggccgac      900

tacgagaagc acaaggtgta cgcctgtgag gtgacccacc agggcctgtc cagccctgtg      960

accaagtcct tcaaccgggg cgagtgc                                          987


<210>  6
<211>  1044
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  6
atgggctggt cctgcatcat cctgtttctg gtggccacag ccaccggcgt gcacagcgaa       60

atcgtgctga cccagagccc cgccaccatg tctgccagcc ctggcgagag agtcaccatc      120

acctgtagcg cccacagcag cgtcagtttc atgcactggt tccagcagaa gcccggcacc      180

agcccaaagc tgtggatcta cagcaccagc agcctcgcca gcggcgtccc agctcgcttt      240

ggcggcagcg gctctggcac cagctacagc ctgaccatca gcagcatgga agccgaggac      300

gccgccacct actactgcca gcagcggagc agctttcccc tgaccttcgg cgctggcacc      360

aagctggaac tgaagggcgg aggcggatcc ggcggcggag gctccgagat tgtgctgaca      420

cagtctccag ccaccatgag cgcctcccca ggcgagcgcg tgacaatcac atgctccgcc      480

cactcctccg tgtcttttat gcattggttt cagcagaaac ctgggacatc ccctaaactc      540

tggatctact ccacctcctc cctggcctcc ggggtgcccg ctagatttgg aggctctggc      600

agcggcacct cctactccct gaccatctcc tctatggaag ctgaagatgc tgcaacatat      660

tattgccagc agagaagctc cttcccactg acatttgggg ccggaacaaa gctcgagctg      720

aagcgtacgg tggccgctcc ttccgtgttc atcttccctc cctccgacga gcagctgaag      780

tccggcaccg cctccgtggt gtgtctgctg aacaacttct accctcggga ggccaaggtg      840

cagtggaagg tggacaacgc cctgcagtcc ggcaactccc aggagtccgt caccgagcag      900

gactccaagg acagcaccta ctccctgtcc tccaccctga ccctgtccaa ggccgactac      960

gagaagcaca aggtgtacgc ctgtgaggtg acccaccagg gcctgtccag ccctgtgacc     1020

aagtccttca accggggcga gtgc                                            1044


<210>  7
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  7

Glu Ala Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Gly Asn Gly Ala Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Ala Asp Pro Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Ile Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Ser Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Ala Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn 
145                 150                 155                 160 


Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Tyr Ile Tyr Pro Gly Asn Gly Ala Thr Asn Tyr Asn Gln Lys Phe Gln 
            180                 185                 190         


Gly Lys Ala Thr Leu Thr Ala Asp Pro Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Gln Ile Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
    210                 215                 220                 


Arg Gly Asp Ser Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                245                 250                 255     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            260                 265                 270         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        275                 280                 285             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    290                 295                 300                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
305                 310                 315                 320 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                325                 330                 335     


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
            340                 345                 350         


<210>  8
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  8

Glu Ala Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Gly Asn Gly Ala Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Ala Asp Pro Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Ile Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Ser Val Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  9
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
            100                 105             


<210>  10
<211>  1056
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  10
gaggcccagc tggtgcagtc tggcgctgag gtggtcaagc ctggggccag cgtgaagatg       60

agctgcaagg ccagcggcta caccttcacc agctacaaca tgcactgggt caagcagacc      120

ccagggcagg gcctggaatg gattggctac atctaccccg gcaacggcgc caccaactac      180

aaccagaagt tccagggcaa ggctaccctg accgccgacc ctagcagcag caccgcctac      240

atgcagatca gcagcctgac cagcgaggac agcgccgtgt acttctgcgc cagaggcgac      300

agcgtgccct tcgcctattg gggccagggc accctggtca cagtgtctgc tggtggcgga      360

ggatccggcg gaggcggaag cgaagcccag ctcgtccaga gcggagccga ggtcgtgaaa      420

ccaggcgcct ctgtgaagat gtcttgcaag gcctctggct atacctttac ctcctataat      480

atgcattggg tcaaacagac acctggacag ggactcgagt ggatcggata tatctatcct      540

ggaaatgggg ccacaaatta caatcagaaa tttcagggga aagccacact gacagccgat      600

cccagctcct ccacagccta tatgcagatt agctctctga cctccgagga ctccgccgtg      660

tatttttgtg cccggggaga ctccgtgcct tttgcttact ggggacaggg cacactcgtg      720

acagtgtccg ccgcttccac caagggcccc tccgtgtttc ctctggcccc cagcagcaag      780

agcacctctg gcggaacagc cgccctgggc tgcctggtca aggactactt ccccgagccc      840

gtgaccgtgt cttggaactc tggcgccctg acctccggcg tccacacctt tccagccgtg      900

ctgcagagca gcggcctgta ctctctgagc agcgtcgtga ccgtgcccag cagcagcctg      960

gggacccaga cctacatctg caacgtgaac cacaagccca gcaacaccaa ggtggacaag     1020

aaggtggaac ccaagagctg cgacaagacc cacacc                               1056


<210>  11
<211>  1113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  11
atgggctggt cctgcatcat cctgtttctg gtggccacag ccaccggcgt gcactctgag       60

gcccagctgg tgcagtctgg cgctgaggtg gtcaagcctg gggccagcgt gaagatgagc      120

tgcaaggcca gcggctacac cttcaccagc tacaacatgc actgggtcaa gcagacccca      180

gggcagggcc tggaatggat tggctacatc taccccggca acggcgccac caactacaac      240

cagaagttcc agggcaaggc taccctgacc gccgacccta gcagcagcac cgcctacatg      300

cagatcagca gcctgaccag cgaggacagc gccgtgtact tctgcgccag aggcgacagc      360

gtgcccttcg cctattgggg ccagggcacc ctggtcacag tgtctgctgg tggcggagga      420

tccggcggag gcggaagcga agcccagctc gtccagagcg gagccgaggt cgtgaaacca      480

ggcgcctctg tgaagatgtc ttgcaaggcc tctggctata cctttacctc ctataatatg      540

cattgggtca aacagacacc tggacaggga ctcgagtgga tcggatatat ctatcctgga      600

aatggggcca caaattacaa tcagaaattt caggggaaag ccacactgac agccgatccc      660

agctcctcca cagcctatat gcagattagc tctctgacct ccgaggactc cgccgtgtat      720

ttttgtgccc ggggagactc cgtgcctttt gcttactggg gacagggcac actcgtgaca      780

gtgtccgccg cttccaccaa gggcccctcc gtgtttcctc tggcccccag cagcaagagc      840

acctctggcg gaacagccgc cctgggctgc ctggtcaagg actacttccc cgagcccgtg      900

accgtgtctt ggaactctgg cgccctgacc tccggcgtcc acacctttcc agccgtgctg      960

cagagcagcg gcctgtactc tctgagcagc gtcgtgaccg tgcccagcag cagcctgggg     1020

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag     1080

gtggaaccca agagctgcga caagacccac acc                                  1113


<210>  12
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  12

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Ser Ala His Ser Ser Val Ser Phe Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Ser Leu Ala Ser Gly Val Pro Ala Arg Phe Gly Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Phe Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Glu Ala Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro 
        115                 120                 125             


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
    130                 135                 140                 


Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu 
145                 150                 155                 160 


Trp Ile Gly Tyr Ile Tyr Pro Gly Asn Gly Ala Thr Asn Tyr Asn Gln 
                165                 170                 175     


Lys Phe Gln Gly Lys Ala Thr Leu Thr Ala Asp Pro Ser Ser Ser Thr 
            180                 185                 190         


Ala Tyr Met Gln Ile Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
        195                 200                 205             


Phe Cys Ala Arg Gly Asp Ser Val Pro Phe Ala Tyr Trp Gly Gln Gly 
    210                 215                 220                 


Thr Leu Val Thr Val Ser Ala 
225                 230     


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  13

Gly Gly His His His His His His 
1               5               


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  14

Gly Gly Cys Gly Gly His His His His His His 
1               5                   10      


