                         SEQUENCE LISTING

<110>  Imperial Innovations plc
 
<120>  Complement System

<130>  AXH/68508PCT1

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  1271
<212>  DNA
<213>  Homo sapiens

<400>  1
atgctcataa ctgttaatga aagcagattc aaagcaacac caccaccact gaagtatttt       60

tagttatata agattggaac taccaagcat gtggctcctg gtcagtgtaa ttctaatctc      120

acggatatcc tctgttgggg gagaagcaac attttgtgat tttccaaaaa taaaccatgg      180

aattctatat gatgaagaaa aatataagcc attttcccag gttcctacag gggaagtttt      240

ctattactcc tgtgaatata attttgtgtc tccttcaaaa tcattttgga ctcgcataac      300

atgcacagaa gaaggatggt caccaacacc aaagtgtctc agactgtgtt tctttccttt      360

tgtggaaaat ggtcattctg aatcttcagg acaaacacat ctggaaggtg atactgtgca      420

aattatttgc aacacaggat acagacttca aaacaatgag aacaacattt catgtgtaga      480

acggggctgg tccacccctc ccaaatgcag gtccactgac acttcctgtg tgaatccgcc      540

cacagtacaa aatgctcata tactgtcgag acagatgagt aaatatccat ctggtgagag      600

agtacgttat gaatgtagga gcccttatga aatgtttggg gatgaagaag tgatgtgttt      660

aaatggaaac tggacagaac cacctcaatg caaagattct acgggaaaat gtgggccccc      720

tccacctatt gacaatgggg acattacttc attcccgttg tcagtatatg ctccagcttc      780

atcagttgag taccaatgcc agaacttgta tcaacttgag ggtaacaagc gaataacatg      840

tagaaatgga caatggtcag aaccaccaaa atgcttacat ccgtgtgtaa tatcccgaga      900

aattatggaa aattataaca tagcattaag gtggacagcc aaacagaagc tttatttgag      960

aacaggtgaa tcagctgaat ttgtgtgtaa acggggatat cgtctttcat cacgttctca     1020

cacattgcga acaacatgtt gggatgggaa actggagtat ccaacttgtg caaaaagata     1080

gaatcaatca taaaatgcac acctttattc agaactttag tattaaatca gttcttaatt     1140

tcatttttaa gtattgtttt actccttttt attcatacgt aaaattttgg attaatttgt     1200

gaaaatgtaa ttataagctg agaccggtgg ctctcttctt aaaagcacca tattaaaact     1260

tggaaaacta a                                                          1271


<210>  2
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile 
            20                  25                  30          


Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Asp 
    130                 135                 140                 


Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala His Ile Leu Ser 
145                 150                 155                 160 


Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Glu Cys 
                165                 170                 175     


Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn 
            180                 185                 190         


Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys 
        195                 200                 205             


Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu 
    210                 215                 220                 


Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu 
225                 230                 235                 240 


Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp 
                245                 250                 255     


Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile 
            260                 265                 270         


Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu 
        275                 280                 285             


Tyr Leu Arg Thr Gly Glu Ser Ala Glu Phe Val Cys Lys Arg Gly Tyr 
    290                 295                 300                 


Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly 
305                 310                 315                 320 


Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
                325                 330 


<210>  3
<211>  1062
<212>  DNA
<213>  Homo sapiens

<400>  3
cagttagtac actgaaattc aaagtcatgc tcataactgt taatgaaagc agattcaaag       60

caacaccacc accactgaag tatttttagt tatataagat tggaactacc aagcatgtgg      120

ctcctggtca gtgtaattct aatctcacgg atatcctctg ttgggggaga agcaatgttc      180

tgtgattttc caaaaataaa ccatggaatt ctatatgatg aagaaaaata taagccattt      240

tcccaagttc ctacagggga agttttctat tactcctgtg aatataattt tgtgtctcct      300

tcaaaatcct tttggactcg cataacgtgc gcagaagaag gatggtcacc aacaccaaag      360

tgtctcagac tgtgtttctt tccttttgtg gaaaatggtc attctgaatc ttcaggacaa      420

acacatctgg aaggtgatac tgtacaaatt atttgcaaca caggatacag acttcaaaac      480

aatgagaaca acatttcatg tgtagaacgg ggctggtcca ctcctcccaa atgcaggtcc      540

actatttctg cagaaaaatg tgggccccct ccacctattg acaatggaga cattacttca      600

ttcctgttgt cagtatatgc tccaggttca tcagttgagt accagtgcca gaacttgtat      660

caacttgagg gtaacaatca aataacatgt agaaacggac aatggtcaga accaccaaaa      720

tgcttagatc catgtgtaat atcacaagaa attatggaaa aatataacat aaaattaaag      780

tggacaaacc aacaaaagct ttattcaaga acaggtgaca tagttgaatt tgtttgtaaa      840

tctggatatc atccaacaaa atctcattca tttcgagcaa tgtgtcagaa tgggaaactg      900

gtatatccca gttgtgaaga aaaatagaat caatggcatt actattagta aaatgcacac      960

ctttttctga atttactatt atatttgttt tcaatttcat ttttcaagta ctgttttact     1020

catttttatt cataaataaa gttttgtgtt gatttgtgaa aa                        1062


<210>  4
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly Glu Ala Met Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile 
            20                  25                  30          


Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Ala Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Ile 
    130                 135                 140                 


Ser Ala Glu Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile 
145                 150                 155                 160 


Thr Ser Phe Leu Leu Ser Val Tyr Ala Pro Gly Ser Ser Val Glu Tyr 
                165                 170                 175     


Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Asn Gln Ile Thr Cys 
            180                 185                 190         


Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu Asp Pro Cys Val 
        195                 200                 205             


Ile Ser Gln Glu Ile Met Glu Lys Tyr Asn Ile Lys Leu Lys Trp Thr 
    210                 215                 220                 


Asn Gln Gln Lys Leu Tyr Ser Arg Thr Gly Asp Ile Val Glu Phe Val 
225                 230                 235                 240 


Cys Lys Ser Gly Tyr His Pro Thr Lys Ser His Ser Phe Arg Ala Met 
                245                 250                 255     


Cys Gln Asn Gly Lys Leu Val Tyr Pro Ser Cys Glu Glu Lys 
            260                 265                 270 


<210>  5
<211>  1645
<212>  DNA
<213>  Homo sapiens

<400>  5
gaaccacact tggtaactaa taatgaaaga tttcaaaccc caaacagtgc aactgaaact       60

tttgtattag catactactg agaatatcta acatgttgtt actaatcaat gtcattctga      120

ccttgtgggt ttcctgtgct aatggacaag tgaaaccttg tgattttcca gacattaaac      180

atggaggtct atttcatgag aatatgcgta gaccatactt tccagtagct gtaggaaaat      240

attactccta ttactgtgat gaacattttg agactccttc aggaagttac tgggattaca      300

ttcattgcac acaaaatggg tggtcaccag cagtaccatg tctcagaaaa tgttattttc      360

cttatttgga aaatggatat aatcaaaatt atggaagaaa gtttgtacag ggtaactcta      420

cagaagttgc ctgccatcct ggctacggtc ttccaaaagc gcagaccaca gttacatgta      480

cggagaaagg ctggtctcct actcccagat gcatccgtgt cagaacatgc tcaaaatcag      540

atatagaaat tgaaaatgga ttcatttccg aatcttcctc tatttatatt ttaaataaag      600

aaatacaata taaatgtaaa ccaggatatg caacagcaga tggaaattct tcaggatcaa      660

ttacatgttt gcaaaatgga tggtcagcac aaccaatttg cattaattct tcagaaaagt      720

gtgggcctcc tccacctatt agcaatggtg ataccacctc ctttctacta aaagtgtatg      780

tgccacagtc aagagtcgag taccaatgcc agccctacta tgaacttcag ggttctaatt      840

atgtaacatg tagtaatgga gagtggtcgg aaccaccaag atgcatacat ccatgtataa      900

taactgaaga aaacatgaat aaaaataaca taaagttaaa aggaagaagt gacagaaaat      960

attatgcaaa aacaggggat accattgaat ttatgtgtaa attgggatat aatgcaaata     1020

catcaattct atcatttcaa gcagtgtgtc gggaagggat agtggaatac cccagatgcg     1080

aataaggcag cattgttacc ctaaatgtat gtccaacttc cacttttcca cttctcactc     1140

ttatggtctc aaagcttgca aagatagctt ctgatattgt tgtaatttct actttatttc     1200

aaagaaaatt aatataatag tttcaatttg caacttaata tattctcaaa aatatattaa     1260

aacaaactaa attattgctt atgcttgtac taaaataata aaaactactc ttatattgga     1320

cttcttatca atgaattagt aagtatagag acagacagct gaatggcttt ctgcatattg     1380

tatagtatac ctagacatag aaacaaaatg actttagatt ttatttgggg aagtaataat     1440

accataaaat tagatattaa aattgtaagt gaagataaac acactatagt attcccttat     1500

tgtagccatg gtcctctaga tgcagttaac caaatagggt catttttatt aaaagtagtg     1560

tttcctggca aacactgaca ttacatcatt atcatgattt aaaggaaata gtactagaga     1620

aggtgaatta ttatcatttt cctgt                                           1645


<210>  6
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Val Lys Pro Cys Asp Phe Pro Asp Ile Lys His Gly Gly 
            20                  25                  30          


Leu Phe His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly 
        35                  40                  45              


Lys Tyr Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly 
    50                  55                  60                  


Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asn Gly Trp Ser Pro Ala 
65                  70                  75                  80  


Val Pro Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr 
                85                  90                  95      


Asn Gln Asn Tyr Gly Arg Lys Phe Val Gln Gly Asn Ser Thr Glu Val 
            100                 105                 110         


Ala Cys His Pro Gly Tyr Gly Leu Pro Lys Ala Gln Thr Thr Val Thr 
        115                 120                 125             


Cys Thr Glu Lys Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Arg 
    130                 135                 140                 


Thr Cys Ser Lys Ser Asp Ile Glu Ile Glu Asn Gly Phe Ile Ser Glu 
145                 150                 155                 160 


Ser Ser Ser Ile Tyr Ile Leu Asn Lys Glu Ile Gln Tyr Lys Cys Lys 
                165                 170                 175     


Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser Ser Gly Ser Ile Thr Cys 
            180                 185                 190         


Leu Gln Asn Gly Trp Ser Ala Gln Pro Ile Cys Ile Asn Ser Ser Glu 
        195                 200                 205             


Lys Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser Phe 
    210                 215                 220                 


Leu Leu Lys Val Tyr Val Pro Gln Ser Arg Val Glu Tyr Gln Cys Gln 
225                 230                 235                 240 


Pro Tyr Tyr Glu Leu Gln Gly Ser Asn Tyr Val Thr Cys Ser Asn Gly 
                245                 250                 255     


Glu Trp Ser Glu Pro Pro Arg Cys Ile His Pro Cys Ile Ile Thr Glu 
            260                 265                 270         


Glu Asn Met Asn Lys Asn Asn Ile Lys Leu Lys Gly Arg Ser Asp Arg 
        275                 280                 285             


Lys Tyr Tyr Ala Lys Thr Gly Asp Thr Ile Glu Phe Met Cys Lys Leu 
    290                 295                 300                 


Gly Tyr Asn Ala Asn Thr Ser Ile Leu Ser Phe Gln Ala Val Cys Arg 
305                 310                 315                 320 


Glu Gly Ile Val Glu Tyr Pro Arg Cys Glu 
                325                 330 


<210>  7
<211>  1292
<212>  DNA
<213>  Homo sapiens

<400>  7
tgaaagattt caaaccccaa acagtgcaac tgaaactttt gcattactat actactgaga       60

atatctaaca tgttgttact aatcaatgtc attctgacct tgtgggtttc ctgtgctaat      120

ggacaagcaa tgaaaccttg tgagtttcca gaaattcaac atggacatct atattatgag      180

aatacgcgta gaccatactt tccagtagct acaggacaat cttactccta ttactgtgac      240

caaaattttg tgactccttc aggaagttac tgggattaca ttcactgcac acaagatggg      300

tggttgccaa cagtcccatg cctcagaaca tgctcaaaat cagatataga aattgaaaat      360

ggattcattt ctgaatcttc ctctatttat attttaaata aagaaataca atataaatgt      420

aaaccaggat atgcaacagc agatggaaat tcttcaggtt caattacatg tttgcaaaat      480

ggatggtcag cacaaccaat ttgcattaaa ttttgtgata tgcctgtttt tgagaattcc      540

agagccaaga gtaatggcat gcggtttaag ctccatgaca cattggacta cgaatgctac      600

gatggatatg aaatcagtta tggaaacacc acaggttcca tagtgtgtgg tgaagatggg      660

tggtcccatt tcccaacatg ttataattct tcagaaaagt gtgggcctcc tccacctatt      720

agcaatggtg ataccacctc ctttctacta aaagtgtatg tgccacagtc aagagtcgag      780

taccaatgcc agtcctacta tgaacttcag ggttctaatt atgtaacatg tagtaatgga      840

gagtggtcgg aaccaccaag atgcatacat ccatgtataa taactgaaga aaacatgaat      900

aaaaataaca tacagttaaa aggaaaaagt gacataaaat attatgcaaa aacaggggat      960

accattgaat ttatgtgtaa attgggatat aatgcgaata catcagttct atcatttcaa     1020

gcagtgtgta gggaaggcat agtggaatac cccagatgcg aataaggcag cattgttacc     1080

ctaaatgtat gtccaacttc cacttctcac tcttatggtc tcaaagcttg caaagatagc     1140

ttctgatatt gttgtaattt ctactttatt tcaaagaaaa ttaatataat agtttcaatt     1200

tgcaacttaa tatgttctca aaaatatgtt aaaacaaact aaattattgc ttatgcttgt     1260

actaaaataa taaaaactac ccttatattg ga                                   1292


<210>  8
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Val Lys Pro Cys Asp Phe Pro Glu Ile Gln His Gly Gly 
            20                  25                  30          


Leu Tyr Tyr Lys Ser Leu Arg Arg Leu Tyr Phe Pro Ala Ala Ala Gly 
        35                  40                  45              


Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln Asn Phe Val Thr Pro Ser Gly 
    50                  55                  60                  


Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asp Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Val Pro Cys Leu Arg Thr Cys Ser Lys Ser Asp Val Glu Ile Glu Asn 
                85                  90                  95      


Gly Phe Ile Ser Glu Ser Ser Ser Ile Tyr Ile Leu Asn Glu Glu Thr 
            100                 105                 110         


Gln Tyr Asn Cys Lys Pro Gly Tyr Ala Thr Ala Glu Gly Asn Ser Ser 
        115                 120                 125             


Gly Ser Ile Thr Cys Leu Gln Asn Gly Trp Ser Thr Gln Pro Ile Cys 
    130                 135                 140                 


Ile Lys Phe Cys Asp Met Pro Val Phe Glu Asn Ser Arg Ala Lys Ser 
145                 150                 155                 160 


Asn Gly Met Trp Phe Lys Leu His Asp Thr Leu Asp Tyr Glu Cys Tyr 
                165                 170                 175     


Asp Gly Tyr Glu Ser Ser Tyr Gly Asn Thr Thr Asp Ser Ile Val Cys 
            180                 185                 190         


Gly Glu Asp Gly Trp Ser His Leu Pro Thr Cys Tyr Asn Ser Ser Glu 
        195                 200                 205             


Asn Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser Phe 
    210                 215                 220                 


Pro Gln Lys Val Tyr Leu Pro Trp Ser Arg Val Glu Tyr Gln Cys Gln 
225                 230                 235                 240 


Ser Tyr Tyr Glu Leu Gln Gly Ser Lys Tyr Val Thr Cys Ser Asn Gly 
                245                 250                 255     


Asp Trp Ser Glu Pro Pro Arg Cys Ile Ser Met Lys Pro Cys Glu Phe 
            260                 265                 270         


Pro Glu Ile Gln His Gly His Leu Tyr Tyr Glu Asn Thr Arg Arg Pro 
        275                 280                 285             


Tyr Phe Pro Val Ala Thr Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln 
    290                 295                 300                 


Asn Phe Val Thr Pro Ser Gly Ser Tyr Trp Asp Tyr Ile His Cys Thr 
305                 310                 315                 320 


Gln Asp Gly Trp Leu Pro Thr Val Pro Cys Leu Arg Thr Cys Ser Lys 
                325                 330                 335     


Ser Asp Ile Glu Ile Glu Asn Gly Phe Ile Ser Glu Ser Ser Ser Ile 
            340                 345                 350         


Tyr Ile Leu Asn Lys Glu Ile Gln Tyr Lys Cys Lys Pro Gly Tyr Ala 
        355                 360                 365             


Thr Ala Asp Gly Asn Ser Ser Gly Ser Ile Thr Cys Leu Gln Asn Gly 
    370                 375                 380                 


Trp Ser Ala Gln Pro Ile Cys Ile Lys Phe Cys Asp Met Pro Val Phe 
385                 390                 395                 400 


Glu Asn Ser Arg Ala Lys Ser Asn Gly Met Arg Phe Lys Leu His Asp 
                405                 410                 415     


Thr Leu Asp Tyr Glu Cys Tyr Asp Gly Tyr Glu Ile Ser Tyr Gly Asn 
            420                 425                 430         


Thr Thr Gly Ser Ile Val Cys Gly Glu Asp Gly Trp Ser His Phe Pro 
        435                 440                 445             


Thr Cys Tyr Asn Ser Ser Glu Lys Cys Gly Pro Pro Pro Pro Ile Ser 
    450                 455                 460                 


Asn Gly Asp Thr Thr Ser Phe Leu Leu Lys Val Tyr Val Pro Gln Ser 
465                 470                 475                 480 


Arg Val Glu Tyr Gln Cys Gln Ser Tyr Tyr Glu Leu Gln Gly Ser Asn 
                485                 490                 495     


Tyr Val Thr Cys Ser Asn Gly Glu Trp Ser Glu Pro Pro Arg Cys Ile 
            500                 505                 510         


His Pro Cys Ile Ile Thr Glu Glu Asn Met Asn Lys Asn Asn Ile Gln 
        515                 520                 525             


Leu Lys Gly Lys Ser Asp Ile Lys Tyr Tyr Ala Lys Thr Gly Asp Thr 
    530                 535                 540                 


Ile Glu Phe Met Cys Lys Leu Gly Tyr Asn Ala Asn Thr Ser Val Leu 
545                 550                 555                 560 


Ser Phe Gln Ala Val Cys Arg Glu Gly Ile Val Glu Tyr Pro Arg Cys 
                565                 570                 575     


Glu 
    


<210>  9
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Glu Val Lys Pro Cys Asp Phe Pro Glu Ile Gln His Gly 
            20                  25                  30          


Gly Leu Tyr Tyr Lys Ser Leu Arg Arg Leu Tyr Phe Pro Ala Ala Ala 
        35                  40                  45              


Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln Asn Phe Val Thr Pro Ser 
    50                  55                  60                  


Gly Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asp Gly Trp Ser Pro 
65                  70                  75                  80  


Thr Val Pro Cys Leu Arg Thr Cys Ser Lys Ser Asp Ile Glu Ile Glu 
                85                  90                  95      


Asn Gly Phe Ile Ser Glu Ser Ser Ser Ile Tyr Ile Leu Asn Lys Glu 
            100                 105                 110         


Ile Gln Tyr Lys Cys Lys Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser 
        115                 120                 125             


Ser Gly Ser Ile Thr Cys Leu Gln Asn Gly Trp Ser Ala Gln Pro Ile 
    130                 135                 140                 


Cys Ile Lys Phe Cys Asp Met Pro Val Phe Glu Asn Ser Arg Ala Lys 
145                 150                 155                 160 


Ser Asn Gly Met Arg Phe Lys Leu His Asp Thr Leu Asp Tyr Glu Cys 
                165                 170                 175     


Tyr Asp Gly Tyr Glu Ile Ser Tyr Gly Asn Thr Thr Gly Ser Ile Val 
            180                 185                 190         


Cys Gly Glu Asp Gly Trp Ser His Phe Pro Thr Cys Tyr Asn Ser Ser 
        195                 200                 205             


Glu Lys Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser 
    210                 215                 220                 


Phe Leu Leu Lys Val Tyr Val Pro Gln Ser Arg Val Glu Tyr Gln Cys 
225                 230                 235                 240 


Gln Ser Tyr Tyr Glu Leu Gln Gly Ser Asn Tyr Val Thr Cys Ser Asn 
                245                 250                 255     


Gly Glu Trp Ser Glu Pro Pro Arg Cys Ile His Pro Cys Ile Ile Thr 
            260                 265                 270         


Glu Glu Asn Met Asn Lys Asn Asn Ile Gln Leu Lys Gly Lys Ser Asp 
        275                 280                 285             


Ile Lys Tyr Tyr Ala Lys Thr Gly Asp Thr Ile Glu Phe Met Cys Lys 
    290                 295                 300                 


Leu Gly Tyr Asn Ala Asn Thr Ser Val Leu Ser Phe Gln Ala Val Cys 
305                 310                 315                 320 


Arg Glu Gly Ile Val Glu Tyr Pro Arg Cys Glu 
                325                 330     


<210>  10
<211>  2810
<212>  DNA
<213>  Homo sapiens

<400>  10
agtacattga aattcaaagt catgcttgta actgttaatg aaagcagatt taaagcaaca       60

ccaccatcac tggagtattt ttagttatat acgattgaga ctaccaagca tgttgctctt      120

attcagtgta atcctaatct catgggtatc cactgttggg ggagaaggaa cactttgtga      180

ttttccaaaa atacaccatg gatttctgta tgatgaagaa gattataacc ctttttccca      240

agttcctaca ggggaagttt tctattactc ctgtgaatat aattttgtgt ctccttcaaa      300

atccttttgg actcgcataa catgcacaga agaaggatgg tcaccaacac cgaagtgtct      360

cagaatgtgt tcctttcctt ttgtgaaaaa tggtcattct gaatcttcag gactaataca      420

tctggaaggt gatactgtac aaattatttg caacacagga tacagccttc aaaacaatga      480

gaaaaacatt tcgtgtgtag aacggggctg gtccactcct cccatatgca gcttcactaa      540

aggagaatgt catgttccaa ttttagaagc caatgtagat gctcagccaa aaaaagaaag      600

ctacaaagtt ggagacgtgt tgaaattctc ctgcagaaaa aatcttataa gagttggatc      660

agactcagtt caatgttacc aatttgggtg gtcacctaac tttccaacat gcaaaggaca      720

agtacgatca tgtggtccac ctcctcaact ctccaatggt gaagttaagg agataagaaa      780

agaggaatat ggacacaatg aagtagtgga atatgattgc aatcctaatt ttataataaa      840

cgggcctaag aaaatacaat gtgtggatgg agaatggaca actttaccca cttgtgttga      900

acaagtgaaa acatgtggat acatacctga actcgagtac ggttatgttc agccgtctgt      960

ccctccctat caacatggag tttcagtcga ggtgaattgc agaaatgaat atgcaatgat     1020

tggaaataac atgattacct gtattaatgg aatatggaca gagcttccta tgtgtgttgc     1080

aacacaccaa cttaagaggt gcaaaatagc aggagttaat ataaaaacat tactcaagct     1140

atctgggaaa gaatttaatc ataattctag aatacgttac agatgttcag acatcttcag     1200

atacaggcac tcagtctgta taaacgggaa atggaatcct gaagtagact gcacagaaaa     1260

aagggaacaa ttctgcccac cgccacctca gatacctaat gctcagaata tgacaaccac     1320

agtgaattat caggatggag aaaaagtagc tgttctctgt aaagaaaact atctacttcc     1380

agaagcaaaa gaaattgtat gtaaagatgg acgatggcaa tcattaccac gctgtgttga     1440

gtctactgca tattgtgggc cccctccatc tattaacaat ggagatacca cctcattccc     1500

attatcagta tatcctccag ggtcaacagt gacgtaccgt tgccagtcct tctataaact     1560

ccagggctct gtaactgtaa catgcagaaa taaacagtgg tcagaaccac caagatgcct     1620

agatccatgt gtggtatctg aagaaaacat gaacaaaaat aacatacagt taaaatggag     1680

aaacgatgga aaactctatg caaaaacagg ggatgctgtt gaattccagt gtaaattccc     1740

acataaagcg atgatatcat caccaccatt tcgagcaatc tgtcaggaag ggaaatttga     1800

atatcctata tgtgaatgaa gcaagcataa ttttcctgaa tatattcttc aaacatccat     1860

ctatgctaaa agtagccatt atgtagccaa ttctgtagtt acttctttta ttctttcagg     1920

tgttgtttaa ctcagtttta tttagaactc tggattttta gagctttaga aatttgtaag     1980

ctgagagaac aatgtttcac ttaataggag ggtgtcttag tccatattac attgttataa     2040

cagagtatca cagactggat aacttctaac caatagttta tttgtttcat aaatctaaaa     2100

gctgagaagt ccaagatggt ggggctgcct ctggtgaggg tcttctcgaa gcatcataat     2160

atgctggaag gcatcacaac atggtggaag ggatcacgtg gcaaaagagc atgtacatgg     2220

gagtgagaga aaaagagaga gagagacaga gtggcggggg cggggaggag cgcaaactca     2280

tcctttataa agacaccact cctgagataa caatccaatc ccatgataat gacattaatc     2340

cattcaagaa gatagagctc tcgtgactta atcaccttct aaagatctca cctgacaaca     2400

ctgttgcatt ggcagttaag tttccacgta aactttcggg gacacattca aaccacagga     2460

gaaactcaaa ttgttcctgg gcaaatcaca acatggggaa ttttattcat aaatgtccac     2520

agaaacagta aatgttctcg cttcagtact taattcatct aatccctcct gtttgtctca     2580

aattatagga taactttgaa actttctgaa ttaacgttat ttaaaaggaa atgtagatgt     2640

tattttagtc tctatcttca tgttattatc acttaaaaac ctgcgaaagc tgtcaacttt     2700

tgtggttgta gcaagtatta ataaatattt ataaatcctc taatgtaagt ctagctacct     2760

atccaatact aaatacccct taaagtatta aatgcactat ctgctgtaaa                2810


<210>  11
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Leu Leu Leu Phe Ser Val Ile Leu Ile Ser Trp Val Ser Thr Val 
1               5                   10                  15      


Gly Gly Glu Gly Thr Leu Cys Asp Phe Pro Lys Ile His His Gly Phe 
            20                  25                  30          


Leu Tyr Asp Glu Glu Asp Tyr Asn Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Met Cys Ser Phe Pro Phe Val Lys Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Leu Ile His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Ser Leu Gln Asn Asn Glu Lys Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Ile Cys Ser Phe Thr Lys 
    130                 135                 140                 


Gly Glu Cys His Val Pro Ile Leu Glu Ala Asn Val Asp Ala Gln Pro 
145                 150                 155                 160 


Lys Lys Glu Ser Tyr Lys Val Gly Asp Val Leu Lys Phe Ser Cys Arg 
                165                 170                 175     


Lys Asn Leu Ile Arg Val Gly Ser Asp Ser Val Gln Cys Tyr Gln Phe 
            180                 185                 190         


Gly Trp Ser Pro Asn Phe Pro Thr Cys Lys Gly Gln Val Arg Ser Cys 
        195                 200                 205             


Gly Pro Pro Pro Gln Leu Ser Asn Gly Glu Val Lys Glu Ile Arg Lys 
    210                 215                 220                 


Glu Glu Tyr Gly His Asn Glu Val Val Glu Tyr Asp Cys Asn Pro Asn 
225                 230                 235                 240 


Phe Ile Ile Asn Gly Pro Lys Lys Ile Gln Cys Val Asp Gly Glu Trp 
                245                 250                 255     


Thr Thr Leu Pro Thr Cys Val Glu Gln Val Lys Thr Cys Gly Tyr Ile 
            260                 265                 270         


Pro Glu Leu Glu Tyr Gly Tyr Val Gln Pro Ser Val Pro Pro Tyr Gln 
        275                 280                 285             


His Gly Val Ser Val Glu Val Asn Cys Arg Asn Glu Tyr Ala Met Ile 
    290                 295                 300                 


Gly Asn Asn Met Ile Thr Cys Ile Asn Gly Ile Trp Thr Glu Leu Pro 
305                 310                 315                 320 


Met Cys Val Ala Thr His Gln Leu Lys Arg Cys Lys Ile Ala Gly Val 
                325                 330                 335     


Asn Ile Lys Thr Leu Leu Lys Leu Ser Gly Lys Glu Phe Asn His Asn 
            340                 345                 350         


Ser Arg Ile Arg Tyr Arg Cys Ser Asp Ile Phe Arg Tyr Arg His Ser 
        355                 360                 365             


Val Cys Ile Asn Gly Lys Trp Asn Pro Glu Val Asp Cys Thr Glu Lys 
    370                 375                 380                 


Arg Glu Gln Phe Cys Pro Pro Pro Pro Gln Ile Pro Asn Ala Gln Asn 
385                 390                 395                 400 


Met Thr Thr Thr Val Asn Tyr Gln Asp Gly Glu Lys Val Ala Val Leu 
                405                 410                 415     


Cys Lys Glu Asn Tyr Leu Leu Pro Glu Ala Lys Glu Ile Val Cys Lys 
            420                 425                 430         


Asp Gly Arg Trp Gln Ser Leu Pro Arg Cys Val Glu Ser Thr Ala Tyr 
        435                 440                 445             


Cys Gly Pro Pro Pro Ser Ile Asn Asn Gly Asp Thr Thr Ser Phe Pro 
    450                 455                 460                 


Leu Ser Val Tyr Pro Pro Gly Ser Thr Val Thr Tyr Arg Cys Gln Ser 
465                 470                 475                 480 


Phe Tyr Lys Leu Gln Gly Ser Val Thr Val Thr Cys Arg Asn Lys Gln 
                485                 490                 495     


Trp Ser Glu Pro Pro Arg Cys Leu Asp Pro Cys Val Val Ser Glu Glu 
            500                 505                 510         


Asn Met Asn Lys Asn Asn Ile Gln Leu Lys Trp Arg Asn Asp Gly Lys 
        515                 520                 525             


Leu Tyr Ala Lys Thr Gly Asp Ala Val Glu Phe Gln Cys Lys Phe Pro 
    530                 535                 540                 


His Lys Ala Met Ile Ser Ser Pro Pro Phe Arg Ala Ile Cys Gln Glu 
545                 550                 555                 560 


Gly Lys Phe Glu Tyr Pro Ile Cys Glu 
                565                 


<210>  12
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  12

Pro Phe Ser Gln Val Pro Thr Gly Glu Val Phe Tyr Tyr Ser Cys Glu 
1               5                   10                  15      


Tyr Asn Phe Val Ser Pro Ser Lys Ser Phe Trp Thr Arg Ile Thr Cys 
            20                  25                  30          


<210>  13
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  13

Tyr Tyr Ser Cys Glu Tyr Asn 
1               5           


<210>  14
<211>  50
<212>  DNA
<213>  Homo sapiens

<400>  14
gctgacaagg atgatctcga gaaaagagaa gcaacatttt gtgattttcc                  50


<210>  15
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  15
gccgcccatg gacatctaag tggacctgca tttgg                                  35


<210>  16
<211>  44
<212>  DNA
<213>  Homo sapiens

<400>  16
gagatatacc atgggcactt cctgtgtgaa tccgcccaca gtac                        44


<210>  17
<211>  46
<212>  DNA
<213>  Homo sapiens

<400>  17
gccggatcct ctatcttttt gcacaagttg gatactccag tttccc                      46


<210>  18
<211>  47
<212>  DNA
<213>  Homo sapiens

<400>  18
tataccatgg gcgaaaaatg tgggccccct ccacctattg acaatgg                     47


<210>  19
<211>  47
<212>  DNA
<213>  Homo sapiens

<400>  19
cgtgccggat cctatttttc ttcacaactg ggatatacca gtttccc                     47


<210>  20
<211>  67
<212>  DNA
<213>  Homo sapiens

<400>  20
caagttccta caggggaagt tttctcttac tactgtgaag agaattttgt gtctccttca       60

aaatcct                                                                 67


<210>  21
<211>  67
<212>  DNA
<213>  Homo sapiens

<400>  21
aggattttga aggagacaca aaattctctt cacagtagta agagaaaact tcccctgtag       60

gaacttg                                                                 67


<210>  22
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  22

Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile Leu Tyr Asp Glu 
1               5                   10                  15      


Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly Glu Val Phe Tyr 
            20                  25                  30          


Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys Ser Phe Trp Thr 
        35                  40                  45              


Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr Pro Lys Cys Leu 
    50                  55                  60                  


Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His Ser Glu Ser Ser 
65                  70                  75                  80  


Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile Ile Cys Asn Thr 
                85                  90                  95      


Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser Cys Val Glu Arg 
            100                 105                 110         


Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser 
        115                 120         


<210>  23
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile Leu Tyr Asp Glu 
1               5                   10                  15      


Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly Glu Val Phe Tyr 
            20                  25                  30          


Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys Ser Phe Trp Thr 
        35                  40                  45              


Arg Ile Thr Cys Ala Glu Glu Gly Trp Ser Pro Thr Pro Lys Cys Leu 
    50                  55                  60                  


Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His Ser Glu Ser Ser 
65                  70                  75                  80  


Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile Ile Cys Asn Thr 
                85                  90                  95      


Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser Cys Val Glu Arg 
            100                 105                 110         


Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser 
        115                 120         


<210>  24
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  24

Thr Leu Cys Asp Phe Pro Lys Ile His His Gly Phe Leu Tyr Asp Glu 
1               5                   10                  15      


Glu Asp Tyr Asn Pro Phe Ser Gln Val Pro Thr Gly Glu Val Phe Tyr 
            20                  25                  30          


Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys Ser Phe Trp Thr 
        35                  40                  45              


Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr Pro Lys Cys Leu 
    50                  55                  60                  


Arg Met Cys Ser Phe Pro Phe Val Lys Asn Gly His Ser Glu Ser Ser 
65                  70                  75                  80  


Gly Leu Ile His Leu Glu Gly Asp Thr Val Gln Ile Ile Cys Asn Thr 
                85                  90                  95      


Gly Tyr Ser Leu Gln Asn Asn Glu Lys Asn Ile Ser Cys Val Glu Arg 
            100                 105                 110         


Gly Trp Ser Thr Pro Pro Ile Cys Ser Phe 
        115                 120         


<210>  25
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  25

Arg Thr Cys Ser Lys Ser Asp Ile Glu Ile Glu Asn Gly Phe Ile Ser 
1               5                   10                  15      


Glu Ser Ser Ser Ile Tyr Ile Leu Asn Lys Glu Ile Gln Tyr Lys Cys 
            20                  25                  30          


Lys Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser Ser Gly Ser Ile Thr 
        35                  40                  45              


Cys Leu Gln Asn Gly Trp Ser Ala Gln Pro Ile Cys Ile Asn 
    50                  55                  60          


<210>  26
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  26

Arg Thr Cys Ser Lys Ser Asp Ile Glu Ile Glu Asn Gly Phe Ile Ser 
1               5                   10                  15      


Glu Ser Ser Ser Ile Tyr Ile Leu Asn Lys Glu Ile Gln Tyr Lys Cys 
            20                  25                  30          


Lys Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser Ser Gly Ser Ile Thr 
        35                  40                  45              


Cys Leu Gln Asn Gly Trp Ser Ala Gln Pro Ile Cys Ile Lys 
    50                  55                  60          


<210>  27
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  27

Arg Thr Cys Ser Lys Ser Asp Ile Glu Ile Glu Asn Gly Phe Ile Ser 
1               5                   10                  15      


Glu Ser Ser Ser Ile Tyr Ile Leu Asn Lys Glu Ile Gln Tyr Lys Cys 
            20                  25                  30          


Lys Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser Ser Gly Ser Ile Thr 
        35                  40                  45              


Cys Leu Gln Asn Gly Trp Ser Ala Gln Pro Ile Cys Ile 
    50                  55                  60      


