                         SEQUENCE LISTING

<110>  INSERM
 
<120>  METHODS AND PHARMACEUTICAL COMPOSITION FOR THE TREATMENT AND THE 
       PREVENTION FRIEDREICH ATAXIA

<130>  BIO12364 PUCCIO

<160>  2     

<170>  PatentIn version 3.3

<210>  1
<211>  7168
<212>  DNA
<213>  Homo sapiens

<400>  1
agtctccctt gggtcagggg tcctggttgc actccgtgct ttgcacaaag caggctctcc     60

atttttgtta aatgcacgaa tagtgctaag ctgggaagtt cttcctgagg tctaacctct    120

agctgctccc ccacagaaga gtgcctgcgg ccagtggcca ccaggggtcg ccgcagcacc    180

cagcgctgga gggcggagcg ggcggcagac ccggagcagc atgtggactc tcgggcgccg    240

cgcagtagcc ggcctcctgg cgtcacccag cccagcccag gcccagaccc tcacccgggt    300

cccgcggccg gcagagttgg ccccactctg cggccgccgt ggcctgcgca ccgacatcga    360

tgcgacctgc acgccccgcc gcgcaagttc gaaccaacgt ggcctcaacc agatttggaa    420

tgtcaaaaag cagagtgtct atttgatgaa tttgaggaaa tctggaactt tgggccaccc    480

aggctctcta gatgagacca cctatgaaag actagcagag gaaacgctgg actctttagc    540

agagtttttt gaagaccttg cagacaagcc atacacgttt gaggactatg atgtctcctt    600

tgggagtggt gtcttaactg tcaaactggg tggagatcta ggaacctatg tgatcaacaa    660

gcagacgcca aacaagcaaa tctggctatc ttctccatcc agtggaccta agcgttatga    720

ctggactggg aaaaactggg tgtactccca cgacggcgtg tccctccatg agctgctggc    780

cgcagagctc actaaagcct taaaaaccaa actggacttg tcttccttgg cctattccgg    840

aaaagatgct tgatgcccag ccccgtttta aggacattaa aagctatcag gccaagaccc    900

cagcttcatt atgcagctga ggtctgtttt ttgttgttgt tgttgtttat tttttttatt    960

cctgcttttg aggacagttg ggctatgtgt cacagctctg tagaaagaat gtgttgcctc   1020

ctaccttgcc cccaagttct gatttttaat ttctatggaa gattttttgg attgtcggat   1080

ttcctccctc acatgatacc ccttatcttt tataatgtct tatgcctata cctgaatata   1140

acaaccttta aaaaagcaaa ataataagaa ggaaaaattc caggagggaa aatgaattgt   1200

cttcactctt cattctttga aggatttact gcaagaagta catgaagagc agctggtcaa   1260

cctgctcact gttctatctc caaatgagac acattaaagg gtagcctaca aatgttttca   1320

ggcttctttc aaagtgtaag cacttctgag ctctttagca ttgaagtgtc gaaagcaact   1380

cacacgggaa gatcatttct tatttgtgct ctgtgactgc caaggtgtgg cctgcactgg   1440

gttgtccagg gagacctagt gctgtttctc ccacatattc acatacgtgt ctgtgtgtat   1500

atatattttt tcaatttaaa ggttagtatg gaatcagctg ctacaagaat gcaaaaaatc   1560

ttccaaagac aagaaaagag gaaaaaaagc cgttttcatg agctgagtga tgtagcgtaa   1620

caaacaaaat catggagctg aggaggtgcc ttgtaaacat gaaggggcag ataaaggaag   1680

gagatactca tgttgataaa gagagccctg gtcctagaca tagttcagcc acaaagtagt   1740

tgtccctttg tggacaagtt tcccaaattc cctggacctc tgcttcccca tctgttaaat   1800

gagagaatag agtatggttg attcccagca ttcagtggtc ctgtcaagca acctaacagg   1860

ctagttctaa ttccctattg ggtagatgag gggatgacaa agaacagttt ttaagctata   1920

taggaaacat tgttattggt gttgccctat cgtgatttca gttgaattca tgtgaaaata   1980

atagccatcc ttggcctggc gcggtggctc acacctgtaa tcccagcact tttggaggcc   2040

aaggtgggtg gatcacctga ggtcaggagt tcaagaccag cctggccaac atgatgaaac   2100

cccgtctcta ctaaaaatac aaaaaattag ccgggcatga tggcaggtgc ctgtaatccc   2160

agctacttgg gaggctgaag cggaagaatc gcttgaaccc agaggtggag gttgcagtga   2220

gccgagatcg tgccattgca ctgtaacctg ggtgactgag caaaactctg tctcaaaata   2280

ataataacaa tataataata ataatagcca tcctttattg tacccttact gggttaatcg   2340

tattatacca cattacctca ttttaatttt tactgacctg cactttatac aaagcaacaa   2400

gcctccagga cattaaaatt catgcaaagt tatgctcatg ttatattatt ttcttactta   2460

aagaaggatt tattagtggc tgggcatggt ggcgtgcacc tgtaatccca ggtactcagg   2520

aggctgagac gggagaattg cttgacccca ggcggaggag gttacagtga gtcgagatcg   2580

tacctgagcg acagagcgag actccgtctc aaaaaaaaaa aaaaggaggg tttattaatg   2640

agaagtttgt attaatatgt agcaaaggct tttccaatgg gtgaataaaa acacattcca   2700

ttaagtcaag ctgggagcag tggcatatac ctatagtccc agctgcacag gaggctgaga   2760

caggaggatt gcttgaagcc aggaattgga gatcagcctg ggcaacacag caagatccta   2820

tctcttaaaa aaagaaaaaa aaacctatta ataataaaac agtataaaca aaagctaaat   2880

aggtaaaata ttttttctga aataaaatta ttttttgagt ctgatggaaa tgtttaagtg   2940

cagtaggcca gtgccagtga gaaaataaat aacatcatac atgtttgtat gtgtttgcat   3000

cttgcttcta ctgaaagttt cagtgcaccc cacttactta gaactcggtg acatgatgta   3060

ctcctttatc tgggacacag cacaaaagag gtatgcagtg gggctgctct gacatgaaag   3120

tggaagttaa ggaatctggg ctcttatggg gtccttgtgg gccagccctt caggcctatt   3180

ttactttcat tttacatata gctctaattg gtttgattat ctcgttccca aggcagtggg   3240

agatccccat ttaaggaaag aaaaggggcc tggcacagtg gctcatgcct gtaatcccag   3300

cactttggga ggctgaggca agtgtatcac ctgaggtcag gagttcaaga ccagcctggc   3360

caacatggca aaatcccgtc tctactaaaa atattaaaaa attggctggg cgtggtggtt   3420

cgtgcctata atttcagcta ctcaggaggc tgaggcagga gaatcgctgt aacctggggg   3480

gtggaggttg cagtgagacg agatcatgcc acttcactcc agcctggcca acagagccat   3540

actccgtctc aaataaataa ataaataaat aaagggactt caaacacatg aacagcagcc   3600

aggggaagaa tcaaaatcat attctgtcaa gcaaactgga aaagtaccac tgtgtgtacc   3660

aatagcctcc ccaccacaga ccctgggagc atcgcctcat ttatggtgtg gtccagtcat   3720

ccatgtgaag gatgagtttc caggaaaagg ttattaaata ttcactgtaa catactggag   3780

gaggtgagga attgcataat acaatcttag aaaacttttt tttccccttt ctattttttg   3840

agacaggatc tcactttggc actcaggctg gaggacagtg gtacaatcaa agctcatggc   3900

agcctcgacc tccctgggct tgggcaatcc tcccacaggt gtgcacctcc atagctggct   3960

aatttgtgta ttttttgtag agatggggtt tcaccatgtt gcccaggctg gtctctaaca   4020

cttaggctca agtgatccac ctgcctcgtc ctcccaagat gctgggatta caggtgtgtg   4080

ccacaggtgt tcatcagaaa gctttttcta ttatttttac cttcttgagt gggtagaacc   4140

tcagccacat agaaaataaa atgttctggc atgacttatt tagctctctg gaattacaaa   4200

gaaggaatga ggtgtgtaaa agagaacctg ggtttttgaa tcacaaattt agaatttaat   4260

cgaaactctg cctcttactt gtttgtagac actgacagtg gcctcatgtt tttttttttt   4320

ttaatctata aaatggagat atctaacatg ttgagcctgg gcccacaggc aaagcacaat   4380

cctgatgtga gaagtactca gttcatgaca actgttgttc tcacatgcat agcataattt   4440

catattcaca ttggaggact tctcccaaaa tatggatgac gttccctact caaccttgaa   4500

cttaatcaaa atactcagtt tacttaactt cgtattagat tctgattccc tggaaccatt   4560

tatcgtgtgc cttaccatgc ttatatttta cttgatcttt tgcatacctt ctaaaactat   4620

tttagccaat ttaaaatttg acagtttgca ttaaattata ggtttacaat atgctttatc   4680

cagctatacc tgccccaaat tctgacagat gcttttgcca cctctaaagg aagacccatg   4740

ttcatagtga tggagtttgt gtggactaac catgcaaggt tgccaaggaa aaatcgcttt   4800

acgcttccaa ggtacacact aagatgaaag taattttagt ccgtgtccag ttggattctt   4860

ggcacatagt tatcttctgc tagaacaaac taaaacagct acatgccagc aagggagaaa   4920

ggggaaggag gggcaaagtt ttgaaatttc atgtaaattt atgctgttca aaacgacgag   4980

ttcatgactt tgtgtataga gtaagaaatg ccttttcttt tttgagacag agtcttgctc   5040

tgtcacccag gctggagtgc agtggcacga tctgggctca ctacaacctc cgcctcctgg   5100

gttcaagcaa ttctctgcct cagcctcccg agtagctggg attacaggtg cctgccacca   5160

cacccggcta atttttgtat ttttagtaga gacggggttt caccatcatg gccaggctgg   5220

tcttgaactc ctgacctagt aatccacctg cctccgcctc ccaaagtgct gggattacag   5280

gcgtgagcca ctgcacccag ccagaaatgc cttctaatct ttggtttatc ttaattagcc   5340

aggacacttg gagtgcatcc cgaagtacct gatcagtggc ccctttggaa tgtgtaaaac   5400

tcagctcact tatatccctg catccgctac agagacagaa tccaagctca tatgttccat   5460

cttctctggc tgtatagttt aaggaatgga aggcaccaga acagatttat tgaaatgttt   5520

attagctgaa gatttattta gacagttgag gaaaacatca gcacccagca gtaaaattgg   5580

ctctcaaaga ttttcttctc ctgtggaaag tcagacctct gaggccccat ccaggtagaa   5640

gtactagtgc aagaagggcc tctgctgtcc acttgtgttt ctgtgatctg tgggaacatt   5700

gttaacgcca catcttgacc tcaaattgtt tagctcctgg ccagacacgg tggctcacac   5760

ctgtaatccc agcactttga gaggctgagg caggtggatc acctgaggtt aggagttcga   5820

ggccagcctg gtcaacatgg taaaaccccg cctctactaa aaatacaaaa attagctggc   5880

cgtagtggcg cacgcctgtt atcccagcta ctcgggaggc tgaggcagga gaattgcttg   5940

aacctgggtg gtggaggttg cagtgagccg agattacacc actgcactcc agcctgggtg   6000

acaagaggga aactccatta aaaaaatgta attcccgtgt ctgccatctt aagtgtaaag   6060

gtggctaaat tatatagaaa aataagacaa tatcatttcc caattacatt cctttcctac   6120

cgcactctat gatgctagct gagatttttc caaaagaaaa tggcttaaat aaaaccctaa   6180

gagaaagaaa aactttaaat ccctccaaag ctcaaaagta atagaaacag atgagtttgg   6240

agtcaggatt tctctgtaag attgcctagg ctgtgtactg cacatctcca ggtgccactg   6300

ttgacagaga ttataactac aatgtgaagt gaatggtgcc actgacagtt atgcaaaccg   6360

tccagagcat agccacctga tcctgctggg attcctcttg ccagtccatc agcagttccc   6420

cttgaaagtt tcaccaaaca tcccttaaat ctgccctctc ctgcccgtcc ccagtggagg   6480

tcctcatcat ttttcacctg catttttgca ggagctttct tatatccacc ttcctccttt   6540

tctctcagcc catcatctag ctacacagtc tccagggtaa gctttcagaa aggcaatctc   6600

ttgtctgtaa aacctaagca ggaccaaggc caagtttctt agcctgaaaa atgtgctttt   6660

ctgactgaac tgttcaggca ctgactctac atataattat gcttttctac cccctcacac   6720

tcaacacttt gactccagca atcccaaatc cccagatccc taagtgtgct gtgctatttt   6780

cacgtggctc tcagacttgg ccagtgctgt ttccattttg gtctttattc cccacatctc   6840

tgcctggggg gtagattcta ccctgaaaaa tgttcttggc acagccttgc aaactcctcc   6900

tccactcagc ctctgcctgg atgcccttga ttgttccatg tcctcagcat accatgtttg   6960

tctttcccag cactgaccta ccatgtgtca cccctgcttg gctgtacctt ccatgaggct   7020

aggactatgt gtctcctttg ttgactgctg ttgccctagc atcttgcaca gttccttgca   7080

cacaattaga gctctataaa tgtcaaataa atgtgttata attatatgtt taagatagtt   7140

gttcaaataa actctaaata accccaac                                      7168


<210>  2
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu 
            20                  25                  30          


Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala 
        35                  40                  45              


Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 
                85                  90                  95      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            100                 105                 110         


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        115                 120                 125             


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    130                 135                 140                 


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
145                 150                 155                 160 


Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser 
                165                 170                 175     


His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys 
            180                 185                 190         


Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys 
        195                 200                 205             


Asp Ala 
    210 


