                         SEQUENCE LISTING

<110>  INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
 
<120>  COMPOSS AGONISTES DU RCEPTEUR KISS1R ET LEUR UTILISATION POUR 
       INDUIRE L'OVULATION CHEZ LES MAMMIFRES

<130>  26648 WO

<150>  FR 1350858
<151>  2013-01-31

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mouse-derived kisspeptin-10


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  1

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Tyr 
1               5                   10  


<210>  2
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human-derived kisspeptin-10


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  2

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  3
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal sequence of synthetic agonist of KISS1R


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Substitution of peptide bond by 1,4-disubstituted 1,2,3-triazole

<220>
<221>  NON_TER
<222>  (1)..(1)

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Gly or Ala

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Leu or an aliphatic alpha-amino acyl analog residue

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Arg, Arg(Me) or a positively charged alpha-amino acyl 
       analog residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Tyr, Phe, Trp or an alpha-amino acyl analog residue of the
       aryl alanine type

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  AMIDATION

<400>  3

Xaa Xaa Xaa Xaa 
1               


<210>  4
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic agonist of KISS1R


<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Substitution of peptide bond by 1,4-disubstituted 1,2,3-triazole

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Gly or Ala

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Leu or an aliphatic alpha-amino acyl analog residue

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Arg, Arg(Me) or a positively charged alpha-amino acyl 
       analog residue

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr, Phe, Trp or an alpha-amino acyl analog residue of the
       aryl alanine type

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  4

Tyr Asn Trp Asn Ser Phe Xaa Xaa Xaa Xaa 
1               5                   10  


<210>  5
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic agonist of KISS1R


<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Substitution of peptide bond by 1,4-disubstituted 1,2,3-triazole

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  5

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Tyr 
1               5                   10  


<210>  6
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic agonist of KISS1R


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Substitution of peptide bond by 1,4-disubstituted 1,2,3-triazole

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  6

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Tyr 
1               5                   10  


<210>  7
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic agonist of KISS1R


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Substitution of peptide bond by 1,4-disubstituted 1,2,3-triazole

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  7

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Tyr 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic agonist of KISS1R


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Substitution of peptide bond by 1,4-disubstituted 1,2,3-triazole

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  8

Tyr Asn Lys Asn Ser Phe Gly Leu Arg Tyr 
1               5                   10  


<210>  9
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic agonist of KISS1R


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (6)..(7)
<223>  Substitution of peptide bond by 1,4-disubstituted 1,2,3-triazole

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Substitution of peptide bond by 1,4-disubstituted 1,2,3-triazole

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  9

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Tyr 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic mouse-derived kisspeptin-10 derivative


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  10

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Tyr 
1               5                   10  


<210>  11
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic agonist of KISS1R


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Side chain modification by gamma-(N-hexadecanoyl-L-glutamyle)

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Substitution of peptide bond by 1,4-disubstituted 1,2,3-triazole

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  11

Tyr Lys Trp Asn Ser Phe Gly Leu Arg Tyr 
1               5                   10  


<210>  12
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic agonist of KISS1R


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal modification by gamma-(N-hexadecanoyl-L-glutamyle)

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Substitution of peptide bond by 1,4-disubstituted 1,2,3-triazole

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  12

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Tyr 
1               5                   10  


<210>  13
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic agonist of KISS1R


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal modification by gamma-(N-hexadecanoyl-L-glutamyle)

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Substitution of peptide bond by 1,4-disubstituted 1,2,3-triazole

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  13

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Trp 
1               5                   10  


<210>  14
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic agonist of KISS1R


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Side chain modification by gamma-(N-hexadecanoyl-L-glutamyle)

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Substitution of peptide bond by 1,4-disubstituted 1,2,3-triazole

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  14

Tyr Asn Lys Asn Ser Phe Gly Leu Arg Tyr 
1               5                   10  


<210>  15
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic agonist of KISS1R


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal modification by gamma-(N-hexadecanoyl-L-glutamyle)

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Substitution of peptide bond by 1,4-disubstituted 1,2,3-triazole

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  METHYLATION

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  15

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Tyr 
1               5                   10  


<210>  16
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic agonist of KISS1R


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal modification by gamma-(N-hexadecanoyl-L-glutamyle)

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Substitution of peptide bond by 1,4-disubstituted 1,2,3-triazole

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  16

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  17
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic agonist of KISS1R


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Side chain modification by TTDS-(gamma-(N-hexadecanoyl-Glu-OH))

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Substitution of peptide bond by 1,4-disubstituted 1,2,3-triazole

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  17

Tyr Lys Trp Asn Ser Phe Gly Leu Arg Tyr 
1               5                   10  


<210>  18
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic agonist of KISS1R


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Side chain modification by 
       2-(succinamido)-6-(4-(4-iodophenyl)butanamido)hexanoate

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Substitution of peptide bond by 1,4-disubstituted 1,2,3-triazole

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  18

Tyr Lys Trp Asn Ser Phe Gly Leu Arg Tyr 
1               5                   10  


<210>  19
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic agonist of KISS1R


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Side chain modification by polethylene glycol (PEG 5000)

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Substitution of peptide bond by 1,4-disubstituted 1,2,3-triazole

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  19

Tyr Lys Trp Asn Ser Phe Gly Leu Arg Tyr 
1               5                   10  


