                         SEQUENCE LISTING

<110>  INSERM
 
<120>  Methods for treating mitochondrial disorders and 
       neurodegenerative disorders

<130>  BIO12247

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  1

Leu Val Ala Asp Asp Pro Asn Asp Pro Tyr Glu Glu His Gly Leu Ile 
1               5                   10                  15      


Leu Pro Asn Gly Asn Ile Asn Trp Asn Cys Pro Cys Leu Gly Gly Met 
            20                  25                  30          


Ala Ser Gly Pro Cys Gly Glu Gln Phe Lys Ser Ala Phe Ser Cys Phe 
        35                  40                  45              


His Tyr Ser Thr Glu Glu Ile Lys Gly Ser Asp Cys Val Asp Gln Phe 
    50                  55                  60                  


Arg Ala Met Gln Glu Cys Met Gln Lys Tyr Pro Asp Leu Tyr Pro Gln 
65                  70                  75                  80  


Glu Asp Glu Asp Glu Glu Glu Glu Arg Glu Lys Lys Pro Ala Glu Gln 
                85                  90                  95      


Ala Glu Glu Thr Ala Pro Ile Glu Ala Thr Ala Thr Lys Glu Glu Glu 
            100                 105                 110         


Gly Ser Ser 
        115 


<210>  2
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Tyr Cys Arg Gln Glu Gly Lys Asp Arg Ile Ile Phe Val Thr 
1               5                   10                  15      


Lys Glu Asp His Glu Thr Pro Ser Ser Ala Glu Leu Val Ala Asp Asp 
            20                  25                  30          


Pro Asn Asp Pro Tyr Glu Glu His Gly Leu Ile Leu Pro Asn Gly Asn 
        35                  40                  45              


Ile Asn Trp Asn Cys Pro Cys Leu Gly Gly Met Ala Ser Gly Pro Cys 
    50                  55                  60                  


Gly Glu Gln Phe Lys Ser Ala Phe Ser Cys Phe His Tyr Ser Thr Glu 
65                  70                  75                  80  


Glu Ile Lys Gly Ser Asp Cys Val Asp Gln Phe Arg Ala Met Gln Glu 
                85                  90                  95      


Cys Met Gln Lys Tyr Pro Asp Leu Tyr Pro Gln Glu Asp Glu Asp Glu 
            100                 105                 110         


Glu Glu Glu Arg Glu Lys Lys Pro Ala Glu Gln Ala Glu Glu Thr Ala 
        115                 120                 125             


Pro Ile Glu Ala Thr Ala Thr Lys Glu Glu Glu Gly Ser Ser 
    130                 135                 140         


<210>  3
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Pro Val Ser Tyr Ser Ser Val Thr Thr Arg Tyr Tyr His Arg Ala 
1               5                   10                  15      


Gly Ala Glu Glu Gly Lys Asp Arg Ile Ile Phe Val Thr Lys Glu Asp 
            20                  25                  30          


His Glu Thr Pro Ser Ser Ala Glu Leu Val Ala Asp Asp Pro Asn Asp 
        35                  40                  45              


Pro Tyr Glu Glu His Gly Leu Ile Leu Pro Asn Gly Asn Ile Asn Trp 
    50                  55                  60                  


Asn Cys Pro Cys Leu Gly Gly Met Ala Ser Gly Pro Cys Gly Glu Gln 
65                  70                  75                  80  


Phe Lys Ser Ala Phe Ser Cys Phe His Tyr Ser Thr Glu Glu Ile Lys 
                85                  90                  95      


Gly Ser Asp Cys Val Asp Gln Phe Arg Ala Met Gln Glu Cys Met Gln 
            100                 105                 110         


Lys Tyr Pro Asp Leu Tyr Pro Gln Glu Asp Glu Asp Glu Glu Glu Glu 
        115                 120                 125             


Arg Glu Lys Lys Pro Ala Glu Gln Ala Glu Glu Thr Ala Pro Ile Glu 
    130                 135                 140                 


Ala Thr Ala Thr Lys Glu Glu Glu Gly Ser Ser 
145                 150                 155 


<210>  4
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Phe Arg Cys Gly Gly Leu Ala Ala Gly Ala Leu Lys Gln Lys Leu 
1               5                   10                  15      


Val Pro Leu Val Arg Thr Val Cys Val Arg Ser Pro Arg Gln Arg Asn 
            20                  25                  30          


Arg Leu Pro Gly Asn Leu Phe Gln Arg Trp His Val Pro Leu Glu Leu 
        35                  40                  45              


Gln Met Thr Arg Gln Met Ala Ser Ser Gly Ala Ser Gly Gly Lys Ile 
    50                  55                  60                  


Asp Asn Ser Val Leu Val Leu Ile Val Gly Leu Ser Thr Val Gly Ala 
65                  70                  75                  80  


Gly Ala Tyr Ala Tyr Lys Thr Met Lys Glu Asp Glu Lys Arg Tyr Asn 
                85                  90                  95      


Glu Arg Ile Ser Gly Leu Gly Leu Thr Pro Glu Gln Lys Gln Lys Lys 
            100                 105                 110         


Ala Ala Leu Ser Ala Ser Glu Gly 
        115                 120 


<210>  5
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Ala Pro Arg Ala Gly Arg Gly Ala Gly Trp Ser Leu Arg Ala 
1               5                   10                  15      


Trp Arg Ala Leu Gly Gly Ile Arg Trp Gly Arg Arg Pro Arg Leu Thr 
            20                  25                  30          


Pro Asp Leu Arg Ala Leu Leu Thr Ser Gly Thr Ser Asp Pro Arg Ala 
        35                  40                  45              


Arg Val Thr Tyr Gly Thr Pro Ser Leu Trp Ala Arg Leu Ser Val Gly 
    50                  55                  60                  


Val Thr Glu Pro Arg Ala Cys Leu Thr Ser Gly Thr Pro Gly Pro Arg 
65                  70                  75                  80  


Ala Gln Leu Thr Ala Val Thr Pro Asp Thr Arg Thr Arg Glu Ala Ser 
                85                  90                  95      


Glu Asn Ser Gly Thr Arg Ser Arg Ala Trp Leu Ala Val Ala Leu Gly 
            100                 105                 110         


Ala Gly Gly Ala Val Leu Leu Leu Leu Trp Gly Gly Gly Arg Gly Pro 
        115                 120                 125             


Pro Ala Val Leu Ala 
    130             


<210>  6
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Phe Arg Cys Gly Gly Leu Ala Ala Gly Ala Leu Lys Gln Lys Leu 
1               5                   10                  15      


Val Pro Leu Val Arg Thr Val Cys Val Arg Ser Pro Arg Gln Arg Asn 
            20                  25                  30          


Arg Leu Pro Gly Asn Leu Phe Gln Arg Trp His Val Pro Leu Glu Leu 
        35                  40                  45              


Gln Met Thr Arg Gln Met Ala Ser Ser Gly Ala Ser Gly Gly Lys Ile 
    50                  55                  60                  


Asp Asn Ser Val Leu Val Leu Ile Val Gly Leu Ser Thr Val Gly Ala 
65                  70                  75                  80  


Gly Ala Tyr Ala Tyr Lys Thr Met Lys Glu Asp Glu Lys Arg Tyr Asn 
                85                  90                  95      


Glu Arg Ile Ser Gly Leu Gly Leu Thr Pro Glu Gln Lys Gln Lys Lys 
            100                 105                 110         


Ala Ala Leu Ser Ala Ser Glu Gly Arg Ser Met Ser Tyr Cys Arg Gln 
        115                 120                 125             


Glu Gly Lys Asp Arg Ile Ile Phe Val Thr Lys Glu Asp His Glu Thr 
    130                 135                 140                 


Pro Ser Ser Ala Glu Leu Val Ala Asp Asp Pro Asn Asp Pro Tyr Glu 
145                 150                 155                 160 


Glu His Gly Leu Ile Leu Pro Asn Gly Asn Ile Asn Trp Asn Cys Pro 
                165                 170                 175     


Cys Leu Gly Gly Met Ala Ser Gly Pro Cys Gly Glu Gln Phe Lys Ser 
            180                 185                 190         


Ala Phe Ser Cys Phe His Tyr Ser Thr Glu Glu Ile Lys Gly Ser Asp 
        195                 200                 205             


Cys Val Asp Gln Phe Arg Ala Met Gln Glu Cys Met Gln Lys Tyr Pro 
    210                 215                 220                 


Asp Leu Tyr Pro Gln Glu Asp Glu Asp Glu Glu Glu Glu Arg Glu Lys 
225                 230                 235                 240 


Lys Pro Ala Glu Gln Ala Glu Glu Thr Ala Pro Ile Glu Ala Thr Ala 
                245                 250                 255     


Thr Lys Glu Glu Glu Gly Ser Ser 
            260                 


<210>  7
<211>  795
<212>  DNA
<213>  Homo sapiens

<400>  7
atgttccggt gtggaggcct ggcggcgggt gctttgaagc agaagctggt gcccttggtg       60

cggaccgtgt gcgtccgaag cccgaggcag aggaaccggc tcccaggcaa cttgttccag      120

cgatggcatg ttcctctaga actccagatg acaagacaaa tggctagctc tggtgcatca      180

gggggcaaaa tcgataattc tgtgttagtc cttattgtgg gcttatcaac agtaggagct      240

ggtgcctatg cctacaagac tatgaaagag gatgaaaaaa gatacaatga aagaatttca      300

gggttagggc tgacaccaga acagaaacag aaaaaggccg cgttatctgc ttcagaagga      360

agatccatgt cctattgccg gcaggaaggg aaggatcgaa tcatatttgt aaccaaagaa      420

gatcatgaaa ctccaagcag tgcagaattg gtggctgatg accccaacga tccatacgag      480

gagcatggat tgatactgcc aaatggaaac attaactgga actgcccatg ccttggggga      540

atggccagcg gtccctgtgg agaacagttt aagtcagcct tttcctgctt ccactatagc      600

acggaggaga tcaaggggtc agactgtgta gaccagttcc gggccatgca ggaatgcatg      660

cagaaatacc cagacctcta tccccaagag gatgaggatg aggaagagga aagagagaag      720

aagccagcag aacaagcaga agaaacagct cccattgagg ccactgcaac caaagaagag      780

gagggatcaa gttaa                                                       795


<210>  8
<211>  37
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  8
cgtaactccc gggatcctaa atgttccggt gtggagg                                37


<210>  9
<211>  36
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  9
cgtaactgcg gccgcttagg gataggctta ccttcg                                 36


<210>  10
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  siRNA

<400>  10
ccgugcuccu ggggcugggt t                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  siRNA

<400>  11
gggcaaaauc gauaauucut t                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  siRNA

<400>  12
gcagacuuuc ucuguguaut t                                                 21


<210>  13
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  siRNA

<400>  13
gcaugcuucu acgauauatt                                                   20


<210>  14
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  siRNA

<400>  14
gcauggauug auacugccat ttt                                               23


<210>  15
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  siRNA

<400>  15
ggaaggaucg aaucauauut t                                                 21


<210>  16
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  siRNA

<400>  16
cgaggagcau ggauugauat ttt                                               23


<210>  17
<211>  27
<212>  PRT
<213>  homo sapiens

<400>  17

Met Ser Tyr Cys Arg Gln Glu Gly Lys Asp Arg Ile Ile Phe Val Thr 
1               5                   10                  15      


Lys Glu Asp His Glu Thr Pro Ser Ser Ala Glu 
            20                  25          


<210>  18
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  18

Glu Gly Lys Asp Arg Ile Ile Phe Val Thr Lys Glu Asp His Glu Thr 
1               5                   10                  15      


Pro Ser Ser Ala Glu 
            20      


<210>  19
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  19
ggcaaaatcg ataattctgt gttagtc                                           27


<210>  20
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  20
ccaccaatta gcaggaaagg aa                                                22


<210>  21
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  21
tgtttctgtt ctggtgtcag                                                   20


<210>  22
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  22
cgagcccgtg gtattcga                                                     18


<210>  23
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  23
ccattgctgg aacaagttgc                                                   20


<210>  24
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  24
acggtgcgtg gaag                                                         14


<210>  25
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Leu Gln Leu Gly Arg Leu Ser Ser Gly Pro Cys Trp Leu Val 
1               5                   10                  15      


Ala Arg Gly Gly Cys Gly Gly Pro Arg Ala Trp Ser Gln Cys Gly Gly 
            20                  25                  30          


Gly Gly Leu Arg Ala Trp Ser Gln Arg Ser Ala Ala Gly Arg Val Cys 
        35                  40                  45              


Arg Pro Pro Gly Pro Ala Gly Thr Glu Gln Ser Arg Gly Leu Gly His 
    50                  55                  60                  


Gly Ser Thr Ser Arg Gly Gly Pro Trp Val Gly Thr Gly Leu Ala Ala 
65                  70                  75                  80  


Ala Leu Ala Gly Leu Val Gly Leu Ala Thr Ala Ala Phe Gly His Val 
                85                  90                  95      


Gln Arg Ala Glu Met Leu Pro Lys Thr 
            100                 105 


