                         SEQUENCE LISTING

<110>  Santaris Pharma A/S
 
<120>  LNA OLIGONUCLEOTIDE CARBOHYDRATE CONJUGATES

<130>  1139WO

<150>  EP13153296.2
<151>  2013-01-30

<150>  EP13157237.2
<151>  2013-02-28

<150>  EP13174092.0
<151>  2013-06-27

<150>  EP13192938.2
<151>  2013-11-14

<150>  EP13192931.7
<151>  2013-11-14

<150>  EP13192930.9
<151>  2013-11-14

<150>  PCT/EP2013/073859
<151>  2013-11-14


<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  1
nnnnnnnnnn nnn                                                          13


<210>  2
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 C6 amino linkage group

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  2
nnnnnnnnnn nnn                                                          13


<210>  3
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 GalNac cluster

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  3
nnnnnnnnnn nnn                                                          13


<210>  4
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 disulphide linked cholesterol conjugate

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  4
nnnnnnnnnn nnn                                                          13


<210>  5
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  disulphide liked cholesterol conjugate

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  5
nnnnnnnnnn nnn                                                          13


<210>  6
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 3xGalNac cluster Conj1a

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (3)..(15)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  6
cannnnnnnn nnnnn                                                        15


<210>  7
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  cholesterol conjugate

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (3)..(15)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  7
cannnnnnnn nnnnn                                                        15


<210>  8
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 monoGalNAc

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  8
gcattggtat tca                                                          13


<210>  9
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 disulphide linked monoGalNAc

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  9
gcattggtat tca                                                          13


<210>  10
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 GalNAc conjugate

<220>
<221>  misc_feature
<222>  (3)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  10
cagcattggt attca                                                        15


<210>  11
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 3xGalNAc cluster Conj2a

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  11
gcattggtat tca                                                          13


<210>  12
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  12
gcattggtat tca                                                          13


<210>  13
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 3xGalNAc cluster Conj1a

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  13
gcattggtat tca                                                          13


<210>  14
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 cholesterol conjugate

<220>
<221>  misc_feature
<222>  (3)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  14
cagcattggt attca                                                        15


<210>  15
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 3xGalNAc cluster Conj2a

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  15
aatgctacaa aaccca                                                       16


<210>  16
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 3xGalNAc cluster Conj2a

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  16
tgctgtgtga gcttgg                                                       16


<210>  17
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 3xGalNAc cluster Conj2a

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  17
gttgacactg tc                                                           12


<210>  18
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 FAM conjugate

<220>
<221>  misc_feature
<222>  (2)..(14)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  18
agcattggta ttca                                                         14


<210>  19
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 FAM conjugate

<220>
<221>  misc_feature
<222>  (4)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  19
gacgcattgg tattca                                                       16


<210>  20
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 FAM conjugate

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  20
gcattggtat tca                                                          13


<210>  21
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 FAM conjugate

<220>
<221>  misc_feature
<222>  (4)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  21
tcagcattgg tattca                                                       16


<210>  22
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  22
tgctacaaaa ccca                                                         14


<210>  23
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  23
aatgctacaa aaccca                                                       16


<210>  24
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  24
aatgctacaa aaccca                                                       16


<210>  25
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  25
gctgtgtgag cttgg                                                        15


<210>  26
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  26
tgctgtgtga gcttgg                                                       16


<210>  27
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 3xGalNAc cluster Conj2a

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  27
tgctacaaaa ccca                                                         14


<210>  28
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 3xGalNAc cluster Conj2a

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  28
aatgctacaa aaccca                                                       16


<210>  29
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 3xGalNAc cluster Conj2a

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  29
gctgtgtgag cttgg                                                        15


<210>  30
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 cholesterol conjugate

<220>
<221>  misc_feature
<222>  (3)..(18)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  30
caaatgctac aaaaccca                                                     18


<210>  31
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 cholesterol conjugate

<220>
<221>  misc_feature
<222>  (3)..(18)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  31
catgctgtgt gagcttgg                                                     18


<210>  32
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 cholesterol conjugate

<220>
<221>  misc_feature
<222>  (3)..(14)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  32
cagttgacac tgtc                                                         14


<210>  33
<211>  9
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  LNA nucleosides, LNA C optionally 5-methyl C

<400>  33
tcacactcc                                                                9


<210>  34
<211>  23
<212>  RNA
<213>  H.sapiens


<220>
<221>  misc_feature
<223>  Mature microRNA-122

<400>  34
uggaguguga caaugguguu ugu                                               23


<210>  35
<211>  9
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  LNA nucleosides, LNA C optionally 5-methyl C

<400>  35
tacaatgca                                                                9


<210>  36
<211>  9
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  LNA nucleosides, LNA C optionally 5-methyl C

<400>  36
acaatgcac                                                                9


<210>  37
<211>  8
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  LNA nucleosides, LNA C optionally 5-methyl C

<400>  37
acaatgca                                                                 8


<210>  38
<211>  7
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  LNA nucleosides, LNA C optionally 5-methyl C

<400>  38
caatgca                                                                  7


<210>  39
<211>  21
<212>  RNA
<213>  H.sapiens


<220>
<221>  misc_feature
<223>  Mature microRNA-33a

<400>  39
gugcauugua guugcauugc a                                                 21


<210>  40
<211>  20
<212>  RNA
<213>  H.sapiens


<220>
<221>  misc_feature
<223>  Mature microRNA-33a

<400>  40
gugcauugcu guugcauugc                                                   20


<210>  41
<211>  9
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  LNA nucleosides, LNA C optionally 5-methyl C

<400>  41
tgataagct                                                                9


<210>  42
<211>  8
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  LNA nucleosides, LNA C optionally 5-methyl C

<400>  42
gataagct                                                                 8


<210>  43
<211>  7
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  LNA nucleosides, LNA C optionally 5-methyl C

<400>  43
ataagct                                                                  7


<210>  44
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  LNA nucleosides at positions 1, 3, 4, 6, 7, 8, 10, 12, 14, 15 & 
       LNA C optionally 5-methyl C

<400>  44
tcagtctgat aagct                                                        15


<210>  45
<211>  22
<212>  RNA
<213>  H.sapiens


<220>
<221>  misc_feature
<223>  Mature microRNA-21

<400>  45
uagcuuauca gacugauguu ga                                                22


<210>  46
<211>  9
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  LNA nucleosides, LNA C optionally 5-methyl C

<400>  46
caatgtagc                                                                9


<210>  47
<211>  8
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  LNA nucleosides, LNA C optionally 5-methyl C

<400>  47
aatgtagc                                                                 8


<210>  48
<211>  7
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  LNA nucleosides, LNA C optionally 5-methyl C

<400>  48
atgtagc                                                                  7


<210>  49
<211>  23
<212>  RNA
<213>  H.sapiens


<220>
<221>  misc_feature
<223>  Mature microRNA-221

<400>  49
agcuacauug ucugcugggu uuc                                               23


<210>  50
<211>  12
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  50
gttgacactg tc                                                           12


<210>  51
<211>  8
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  LNA beta-D-oxy-nucleosides, LNA C are 5-methyl C

<400>  51
cacactcc                                                                 8


<210>  52
<211>  8
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  LNA beta-D-oxy-nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 3xGalNAc conjugate, e.g Conj1a or conj2a.

<400>  52
cacactcc                                                                 8


<210>  53
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  LNA beta-D-oxy-nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (11)..(18)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (11)..(18)
<223>  LNA beta-D-oxy-nucleosides, LNA C are 5-methyl C

<400>  53
cacactccca cacactcc                                                     18


<210>  54
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  LNA beta-D-oxy-nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 3xGalNAc conjugate, e.g Conj1a or conj2a.

<220>
<221>  misc_feature
<222>  (11)..(18)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (11)..(18)
<223>  LNA beta-D-oxy-nucleosides, LNA C are 5-methyl C

<400>  54
cacactccca cacactcc                                                     18


<210>  55
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  55
gaggcatagc agcagg                                                       16


<210>  56
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5GalNAc conjugate, e.g. conj1a or Conj2a

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  56
gaggcatagc agcagg                                                       16


<210>  57
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  LNA nucleosides at position 1, 3, 6, 7, 10, 12, 14 & 15, LNA C 
       are 5-methyl C

<400>  57
ccattgtcac actcc                                                        15


<210>  58
<211>  7
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  LNA nucleosides, LNA C are optionally 5-methyl C

<400>  58
acactcc                                                                  7


<210>  59
<211>  8
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  LNA nucleosides, LNA C are optionally 5-methyl C

<400>  59
cacactcc                                                                 8


<210>  60
<211>  14
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  optional 5 conjugate e.g 5 3xGalNAc conjugate, e.g. conj1a or 
       Conj2a

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  60
attccctgcc tgtg                                                         14


<210>  61
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer poly-oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 conjugate e.g 5 3xGalNAc conjugate, e.g. conj1a or Conj2a

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (15)..(28)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (26)..(28)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  61
gttgacactg tccaattccc tgcctgtg                                          28


<210>  62
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  LNA antisense gapmer oligonucleotide conjugate


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphodiester lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5 FAM conjugate

<220>
<221>  misc_feature
<222>  (3)..(15)
<223>  phosphorothioate lnternucleoside linkages

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  LNA nucleosides, LNA C are 5-methyl C

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA nucleosides, LNA C are 5-methyl C

<400>  62
cagcattggt attca                                                        15


