                         SEQUENCE LISTING

<110>  Thymon LLC
       Goldstein, Gideon
 
<120>  IMMUNOGENIC AND PROPHYLACTIC COMPOSITIONS, METHODS OF MAKING 
       SAME, AND METHODS FOR TREATING AND  PREVENTING TNF-MEDIATED 
       DISEASE AND HIV-1 INFECTION

<130>  GGP14PCT

<150>  61/756583
<151>  2013-01-25

<150>  61/768055
<151>  2013-02-22

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  1

Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val 
1               5                   10                  15      


Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg 
            20                  25                  30          


Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu 
        35                  40                  45              


Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe 
    50                  55                  60                  


Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile 
65                  70                  75                  80  


Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala 
                85                  90                  95      


Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys 
            100                 105                 110         


Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys 
        115                 120                 125             


Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe 
    130                 135                 140                 


Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
145                 150                 155         


<210>  2
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion of two homo sapiens TNF alpha peptides in branching 
       structure with T helper sequence from Tetanus toxid, linkers and 
       lipid cap


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Lys at residue 15 is modified at the epsilon amino group by 
       linking to a T helper peptide modified with a lipid, 
       dipalmitoyl-S-glyceryl

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Glu at residue 30 is modified with an amide

<400>  2

Arg Thr Pro Ser Asp Lys Pro Val Ala His Lys Pro Trp Tyr Glu Pro 
1               5                   10                  15      


Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu 
            20                  25      


<210>  3
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion of a T helper sequence with a polar sequence, spacers with
       attachment to the lipid, dipalmitoyl-S-glyceryl on the N-terminal
       Cys


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Cys at residue 1 is modified with the lipid, 
       dipalmitoyl-S-glyceryl

<400>  3

Cys Ser Lys Lys Lys Lys Ser Ser Gln Tyr Ile Lys Ala Asn Ser Lys 
1               5                   10                  15      


Phe Ile Gly Ile Thr Glu Leu Ser 
            20                  


<210>  4
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  4

Cys Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn 
1               5                   10                  15      


Pro Gln Ala Glu 
            20  


<210>  5
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence combining homo sapiens TNF epitope A2 and F with linkers


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  residue 1 is modified with the lipid, dipalmitoyl-S-glyceryl

<400>  5

Cys Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn 
1               5                   10                  15      


Pro Gln Ala Glu Gly Pro Ser Leu Lys Pro Trp Tyr Glu Pro Ile Tyr 
            20                  25                  30          


Leu Gly Gly Val Gly Gln Leu Glu Lys 
        35                  40      


<210>  6
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide combining linkers T helper pepide and homo sapiens TNF 
       epitope F


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  residue 1 is modified with the lipid, dipalmitoyl-S-glyceryl

<400>  6

Cys Ser Lys Lys Lys Lys Ser Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
1               5                   10                  15      


Ile Gly Ile Thr Glu Leu Gly Pro Ser Leu Lys Pro Trp Tyr Glu Pro 
            20                  25                  30          


Ile Tyr Leu Gly Gly Val Gly Gln Leu Glu Lys 
        35                  40              


<210>  7
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fused seqeunce of linkers T helper sequence polar sequence and 
       homosapiens TNF A2 epitope


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  residue 1 is modified with the lipid, dipalmitoyl-S-glyceryl

<400>  7

Cys Ser Lys Lys Lys Lys Ser Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
1               5                   10                  15      


Ile Gly Ile Thr Glu Leu Gly Pro Ser Leu Ser Arg Thr Pro Ser Asp 
            20                  25                  30          


Lys Pro Val Ala His Val Val Ala Asn Pro Gln Ala Glu 
        35                  40                  45  


<210>  8
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fused sequence of linkers, T helper sequence and both homo 
       sapiens epitopes A2 and F

<400>  8

Cys Ser Lys Lys Lys Lys Ser Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
1               5                   10                  15      


Ile Gly Ile Thr Glu Leu Gly Pro Ser Leu Ser Arg Thr Pro Ser Asp 
            20                  25                  30          


Lys Pro Val Ala His Val Val Ala Asn Pro Gln Ala Glu Gly Pro Ser 
        35                  40                  45              


Leu Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Gly Gln Leu 
    50                  55                  60                  


Glu Lys 
65      


<210>  9
<211>  18
<212>  PRT
<213>  homo sapiens

<400>  9

Cys Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu 
1               5                   10                  15      


Glu Lys 
        


