                         SEQUENCE LISTING

<110>  CASE WESTERN RESERVE UNIVERSITY
 
<120>  N-TERMINAL TRUNCATED INSULIN ANALOGUES

<130>  200512-235

<150>  61/755,020
<151>  2013-01-22

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  1

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210>  2
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  3
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  3

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  4
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Arg or Lys

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Glu or Lys

<400>  4

Phe Val Xaa Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Xaa Thr 
            20                  25                  30  


<210>  5
<211>  27
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is His, Asp, Pro, or Glu

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Phe, Cyclohexanylalanine, penta-fluoro-Phe, 2F-Phe, 
       2-Cl-Phe, 2-Br-Phe, 4F-Phe, 4-Cl-Phe, or 4-Br-Phe

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa is Glu, Lys, Ornithine, Diaminobutyric acid, 
       Diaminoproprionic acid, Norleucine, Aminobutric acid, or 
       Aminoproprionic acid

<400>  5

Gln His Leu Cys Gly Ser Xaa Leu Val Glu Ala Leu Tyr Leu Val Cys 
1               5                   10                  15      


Gly Glu Arg Gly Xaa Phe Tyr Thr Pro Xaa Thr 
            20                  25          


<210>  6
<211>  27
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is His, Asp, Pro, or Glu

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Phe, Cyclohexanylalanine, penta-fluoro-Phe, 2F-Phe, 
       2-Cl-Phe, 2-Br-Phe, 4F-Phe, 4-Cl-Phe, or 4-Br-Phe

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Lys, Arg, Ala, Glu, Gln, or Val

<400>  6

Gln His Leu Cys Gly Ser Xaa Leu Val Glu Ala Leu Tyr Leu Val Cys 
1               5                   10                  15      


Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Pro Thr 
            20                  25          


<210>  7
<211>  27
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is His, Asp, Pro, or Glu

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Phe, Cyclohexanylalanine, penta-fluoro-Phe, 2F-Phe, 
       2-Cl-Phe, 2-Br-Phe, 4F-Phe, 4-Cl-Phe, or 4-Br-Phe

<400>  7

Gln His Leu Cys Gly Ser Xaa Leu Val Glu Ala Leu Tyr Leu Val Cys 
1               5                   10                  15      


Gly Glu Arg Gly Xaa Phe Tyr Thr Pro Glu Thr 
            20                  25          


<210>  8
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Arg, Gln, Glu, His, Lys, or Thr

<400>  8

Gly Ile Val Glu Gln Cys Cys Xaa Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  9
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Arg or Lys

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phe, Cyclohexanylalanine, penta-fluoro-Phe, 2F-Phe, 
       2-Cl-Phe, 2-Br-Phe, 4F-Phe, 4-Cl-Phe, or 4-Br-Phe

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Pro, Lys, or Asp

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Glu, Lys or Pro

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is 0-34 of any amino acid or a break in the amino-acid chain

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa is Glu, Arg or Lys

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Xaa is His, Lys, Arg, Glu, Gln or Thr

<400>  9

Phe Val Xaa Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Xaa Thr Xaa Gly 
            20                  25                  30          


Ile Val Xaa Gln Cys Cys Xaa Ser Ile Cys Ser Leu Tyr Gln Leu Glu 
        35                  40                  45              


Asn Tyr Cys Asn 
    50          


<210>  10
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Ornithine

<400>  10

Gly Phe Phe Tyr Thr Pro Xaa Thr 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  11

Gly Phe Phe Tyr Thr Pro Glu Thr 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  12

Gly Phe Phe Tyr Thr Lys Pro Thr 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Cyclohexanylalanine, penta-fluoro-Phe, 2F-Phe, 2-Cl-Phe, 
       2-Br-Phe, 4F-Phe, 4-Cl-Phe, or 4-Br-Phe

<400>  13

Gly Xaa Phe Tyr Thr Lys Pro Thr 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Cyclohexanylalanine, penta-fluoro-Phe, 2F-Phe, 2-Cl-Phe, 
       2-Br-Phe, 4F-Phe, 4-Cl-Phe, or 4-Br-Phe

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Ornithine

<400>  14

Gly Xaa Phe Tyr Thr Pro Xaa Thr 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Cyclohexanylalanine, penta-fluoro-Phe, 2F-Phe, 2-Cl-Phe, 
       2-Br-Phe, 4F-Phe, 4-Cl-Phe, or 4-Br-Phe

<400>  15

Gly Xaa Phe Tyr Thr Pro Glu Thr 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Cyclohexanylalanine, penta-fluoro-Phe, 2F-Phe, 2-Cl-Phe, 
       2-Br-Phe, 4F-Phe, 4-Cl-Phe, or 4-Br-Phe

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Glu, Lys,Ornithine, Diaminobutyric acid, Diaminoproprionic
       acid, Norleucine, Aminobutric acid, or Aminoproprionic acid

<400>  16

Gly Xaa Phe Tyr Thr Asp Xaa Thr 
1               5               


<210>  17
<211>  90
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  NNN is AGG, AGA, CGG, CGC, AAG or AAA

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is a, c, g, or t

<400>  17
tttgtgnnnc aacacctgtg cggctcacac ctggtggaag ctctctacct agtgtgcggg       60

gaacgaggct agttctacac acccaagacc                                        90


<210>  18
<211>  90
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  NNN is AGA, CGU, AGG, AAG or AAA

<400>  18
tttgttnnnc aacatttgtg tggttctcat ttggttgaag ctttgtactt ggtttgtggt       60

gaaagaggtt agttttacac tccaaagact                                        90


<210>  19
<211>  261
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  NNN is AGG, AGA, CGG, CGC, AAG or AAA

<400>  19
tttgtnnncc aacacctgtg cggctcacac ctggtggaag ctctctacct agtgtgcggg       60

gaacgaggct agttctacac acccaagacc cgccgggagg cagaggacct gcaggtgggg      120

caggtggagc tgggcggcgg ccctggtgca ggcagcctgc agcccttggc cctggagggg      180

tccctgcaga agcgtggcat tgtggaacaa tgctgtacca gcatctgctc cctctaccag      240

ctggagaact actgcaacta g                                                261


<210>  20
<211>  260
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  NNN is AGA, CGU, AGG, AAG or AAA

<400>  20
tttgttnnnc aacatttgtg tggttctcat ttggttgaag ctttgtactt ggtttgtgtg       60

aaagaggtta gttttacact ccaaagacta gaagagaagc tgaagatttg caagttggtc      120

aagttgaatt gggtggtggt ccaggtgctg gttctttgca accattggct ttggaaggtt      180

ctttgcaaaa gagaggtatt gttgaacaat gttgtacttc tatttgttct ttgtaccaat      240

tggaaaacta ctgtaactaa                                                  260


