                         SEQUENCE LISTING

<110>  Roche Diagnostics GmbH
       F. Hoffmann-La Roche AG
 
<120>  Novel glucose oxidases derived from Aspergillus niger

<130>  R75001WO

<150>  13152935.6
<151>  2013-01-28	

<160>  17    

<170>  PatentIn version 3.3

<210>  1
<211>  583
<212>  PRT
<213>  Aspergillus niger

<400>  1

Ser Asn Gly Ile Glu Ala Ser Leu Leu Thr Asp Pro Lys Asp Val Ser 
1               5                   10                  15      


Gly Arg Thr Val Asp Tyr Ile Ile Ala Gly Gly Gly Leu Val Gly Leu 
            20                  25                  30          


Thr Thr Ala Ala Arg Leu Thr Glu Asn Pro Asn Ile Ser Val Leu Val 
        35                  40                  45              


Ile Glu Ser Gly Ser Tyr Glu Ser Asp Arg Gly Pro Ile Ile Glu Asp 
    50                  55                  60                  


Leu Asn Ala Tyr Gly Asp Ile Phe Gly Ser Ser Val Asp His Ala Tyr 
65                  70                  75                  80  


Glu Thr Val Glu Leu Ala Thr Asn Asn Gln Thr Ala Leu Val Arg Ser 
                85                  90                  95      


Gly Asn Gly Leu Gly Gly Ser Thr Leu Val Asn Gly Gly Thr Trp Thr 
            100                 105                 110         


Arg Pro His Lys Ala Gln Val Asp Ser Trp Glu Thr Val Phe Gly Asn 
        115                 120                 125             


Glu Gly Trp Asn Trp Asp Asn Val Ala Ala Tyr Ser Leu Gln Ala Glu 
    130                 135                 140                 


Arg Ala Arg Ala Pro Asn Ala Lys Gln Ile Ala Ala Gly His Tyr Phe 
145                 150                 155                 160 


Asn Ala Ser Cys His Gly Val Asn Gly Thr Val His Ala Gly Pro Arg 
                165                 170                 175     


Asp Thr Gly Asp Asp Tyr Ser Pro Ile Val Lys Ala Leu Met Ser Ala 
            180                 185                 190         


Val Glu Asp Arg Gly Val Pro Thr Lys Lys Asp Phe Gly Cys Gly Asp 
        195                 200                 205             


Pro His Gly Val Ser Met Phe Pro Asn Thr Leu His Glu Asp Gln Val 
    210                 215                 220                 


Arg Ser Asp Ala Ala Arg Glu Trp Leu Leu Pro Asn Tyr Gln Arg Pro 
225                 230                 235                 240 


Asn Leu Gln Val Leu Thr Gly Gln Tyr Val Gly Lys Val Leu Leu Ser 
                245                 250                 255     


Gln Asn Gly Thr Thr Pro Arg Ala Val Gly Val Glu Phe Gly Thr His 
            260                 265                 270         


Lys Gly Asn Thr His Asn Val Tyr Ala Lys His Glu Val Leu Leu Ala 
        275                 280                 285             


Ala Gly Ser Ala Val Ser Pro Thr Ile Leu Glu Tyr Ser Gly Ile Gly 
    290                 295                 300                 


Met Lys Ser Ile Leu Glu Pro Leu Gly Ile Asp Thr Val Val Asp Leu 
305                 310                 315                 320 


Pro Val Gly Leu Asn Leu Gln Asp Gln Thr Thr Ala Thr Val Arg Ser 
                325                 330                 335     


Arg Ile Thr Ser Ala Gly Ala Gly Gln Gly Gln Ala Ala Trp Phe Ala 
            340                 345                 350         


Thr Phe Asn Glu Thr Phe Gly Asp Tyr Ser Glu Lys Ala His Glu Leu 
        355                 360                 365             


Leu Asn Thr Lys Leu Glu Gln Trp Ala Glu Glu Ala Val Ala Arg Gly 
    370                 375                 380                 


Gly Phe His Asn Thr Thr Ala Leu Leu Ile Gln Tyr Glu Asn Tyr Arg 
385                 390                 395                 400 


Asp Trp Ile Val Asn His Asn Val Ala Tyr Ser Glu Leu Phe Leu Asp 
                405                 410                 415     


Thr Ala Gly Val Ala Ser Phe Asp Val Trp Asp Leu Leu Pro Phe Thr 
            420                 425                 430         


Arg Gly Tyr Val His Ile Leu Asp Lys Asp Pro Tyr Leu His His Phe 
        435                 440                 445             


Ala Tyr Asp Pro Gln Tyr Phe Leu Asn Glu Leu Asp Leu Leu Gly Gln 
    450                 455                 460                 


Ala Ala Ala Thr Gln Leu Ala Arg Asn Ile Ser Asn Ser Gly Ala Met 
465                 470                 475                 480 


Gln Thr Tyr Phe Ala Gly Glu Thr Ile Pro Gly Asp Asn Leu Ala Tyr 
                485                 490                 495     


Asp Ala Asp Leu Ser Ala Trp Thr Glu Tyr Ile Pro Tyr His Phe Arg 
            500                 505                 510         


Pro Asn Tyr His Gly Val Gly Thr Cys Ser Met Met Pro Lys Glu Met 
        515                 520                 525             


Gly Gly Val Val Asp Asn Ala Ala Arg Val Tyr Gly Val Gln Gly Leu 
    530                 535                 540                 


Arg Val Ile Asp Gly Ser Ile Pro Pro Thr Gln Met Ser Ser His Val 
545                 550                 555                 560 


Met Thr Val Phe Tyr Ala Met Ala Leu Lys Ile Ser Asp Ala Ile Leu 
                565                 570                 575     


Glu Asp Tyr Ala Ser Met Gln 
            580             


<210>  2
<211>  583
<212>  PRT
<213>  Aspergillus niger

<400>  2

Ser Asn Gly Ile Glu Ala Ser Leu Leu Thr Asp Pro Lys Asp Val Ser 
1               5                   10                  15      


Gly Arg Thr Val Asp Tyr Ile Ile Ala Gly Gly Gly Leu Thr Gly Leu 
            20                  25                  30          


Thr Thr Ala Ala Arg Leu Thr Glu Asn Pro Asn Ile Ser Val Leu Val 
        35                  40                  45              


Ile Glu Ser Gly Ser Tyr Glu Ser Asp Arg Gly Pro Ile Ile Glu Asp 
    50                  55                  60                  


Leu Asn Ala Tyr Gly Asp Ile Phe Gly Ser Ser Val Asp His Ala Tyr 
65                  70                  75                  80  


Glu Thr Val Glu Leu Ala Thr Asn Asn Gln Thr Ala Leu Ile Arg Ser 
                85                  90                  95      


Gly Asn Gly Leu Gly Gly Ser Thr Leu Val Asn Gly Gly Thr Trp Thr 
            100                 105                 110         


Arg Pro His Lys Ala Gln Val Asp Ser Trp Glu Thr Val Phe Gly Asn 
        115                 120                 125             


Glu Gly Trp Asn Trp Asp Asn Val Ala Ala Tyr Ser Leu Gln Ala Glu 
    130                 135                 140                 


Arg Ala Arg Ala Pro Asn Ala Lys Gln Ile Ala Ala Gly His Tyr Phe 
145                 150                 155                 160 


Asn Ala Ser Cys His Gly Val Asn Gly Thr Val His Ala Gly Pro Arg 
                165                 170                 175     


Asp Thr Gly Asp Asp Tyr Ser Pro Ile Val Lys Ala Leu Met Ser Ala 
            180                 185                 190         


Val Glu Asp Arg Gly Val Pro Thr Lys Lys Asp Phe Gly Cys Gly Asp 
        195                 200                 205             


Pro His Gly Val Ser Met Phe Pro Asn Thr Leu His Glu Asp Gln Val 
    210                 215                 220                 


Arg Ser Asp Ala Ala Arg Glu Trp Leu Leu Pro Asn Tyr Gln Arg Pro 
225                 230                 235                 240 


Asn Leu Gln Val Leu Thr Gly Gln Tyr Val Gly Lys Val Leu Leu Ser 
                245                 250                 255     


Gln Asn Gly Thr Thr Pro Arg Ala Val Gly Val Glu Phe Gly Thr His 
            260                 265                 270         


Lys Gly Asn Thr His Asn Val Tyr Ala Lys His Glu Val Leu Leu Ala 
        275                 280                 285             


Ala Gly Ser Ala Val Ser Pro Thr Ile Leu Glu Tyr Ser Gly Ile Gly 
    290                 295                 300                 


Met Lys Ser Ile Leu Glu Pro Leu Gly Ile Asp Thr Val Val Asp Leu 
305                 310                 315                 320 


Pro Val Gly Leu Asn Leu Gln Asp Gln Thr Thr Ala Thr Val Arg Ser 
                325                 330                 335     


Arg Ile Thr Ser Ala Gly Ala Gly Gln Gly Gln Ala Ala Trp Phe Ala 
            340                 345                 350         


Thr Phe Asn Glu Thr Phe Gly Asp Tyr Ser Glu Lys Ala His Glu Leu 
        355                 360                 365             


Leu Asn Thr Lys Leu Glu Gln Trp Ala Glu Glu Ala Val Ala Arg Gly 
    370                 375                 380                 


Gly Phe His Asn Thr Thr Ala Leu Leu Ile Gln Tyr Glu Asn Tyr Arg 
385                 390                 395                 400 


Asp Trp Ile Val Asn His Asn Val Ala Tyr Ser Glu Leu Phe Leu Asp 
                405                 410                 415     


Thr Ala Gly Val Ala Ser Phe Asp Val Trp Asp Leu Leu Pro Phe Thr 
            420                 425                 430         


Arg Gly Tyr Val His Ile Leu Asp Lys Asp Pro Tyr Leu His His Phe 
        435                 440                 445             


Ala Tyr Asp Pro Gln Tyr Phe Leu Asn Glu Leu Asp Leu Leu Gly Gln 
    450                 455                 460                 


Ala Ala Ala Thr Gln Leu Ala Arg Asn Ile Ser Asn Ser Gly Ala Met 
465                 470                 475                 480 


Gln Thr Tyr Phe Ala Gly Glu Thr Ile Pro Gly Asp Asn Leu Ala Tyr 
                485                 490                 495     


Asp Ala Asp Leu Ser Ala Trp Thr Glu Tyr Ile Pro Tyr His Phe Arg 
            500                 505                 510         


Pro Asn Tyr His Gly Val Gly Thr Cys Ser Met Met Pro Lys Glu Met 
        515                 520                 525             


Gly Gly Val Val Asp Asn Ala Ala Arg Val Tyr Gly Val Gln Gly Leu 
    530                 535                 540                 


Arg Val Ile Asp Gly Ser Ile Pro Pro Thr Gln Met Ser Ser His Val 
545                 550                 555                 560 


Met Thr Val Phe Tyr Ala Met Ala Leu Lys Ile Ser Asp Ala Ile Leu 
                565                 570                 575     


Glu Asp Tyr Ala Ser Met Gln 
            580             


<210>  3
<211>  583
<212>  PRT
<213>  Aspergillus niger

<400>  3

Ser Asn Gly Ile Glu Ala Ser Leu Leu Thr Asp Pro Lys Asp Val Ser 
1               5                   10                  15      


Gly Arg Thr Val Asp Tyr Ile Ile Ala Gly Gly Gly Leu Val Gly Leu 
            20                  25                  30          


Thr Thr Ala Ala Arg Leu Thr Glu Asn Pro Asn Ile Ser Val Leu Val 
        35                  40                  45              


Ile Glu Ser Gly Ser Tyr Glu Ser Asp Arg Gly Pro Ile Ile Glu Asp 
    50                  55                  60                  


Leu Asn Ala Tyr Gly Asp Ile Phe Gly Ser Ser Val Asp His Ala Tyr 
65                  70                  75                  80  


Glu Thr Val Glu Leu Ala Thr Asn Asn Gln Thr Ala Leu Val Arg Ser 
                85                  90                  95      


Gly Asn Gly Leu Gly Gly Ser Thr Leu Val Asn Gly Gly Thr Trp Thr 
            100                 105                 110         


Arg Pro His Lys Ala Gln Val Asp Ser Trp Glu Thr Val Phe Gly Asn 
        115                 120                 125             


Glu Gly Trp Asn Trp Asp Asn Val Ala Ala Tyr Ser Leu Gln Ala Glu 
    130                 135                 140                 


Arg Ala Arg Ala Pro Asn Ala Lys Gln Ile Ala Ala Gly His Tyr Phe 
145                 150                 155                 160 


Asn Ala Ser Cys His Gly Val Asn Gly Thr Val His Val Gly Pro Arg 
                165                 170                 175     


Asp Thr Gly Asp Asp Tyr Ser Pro Ile Val Lys Ala Leu Met Ser Ala 
            180                 185                 190         


Val Glu Asp Arg Gly Val Pro Thr Lys Lys Asp Phe Gly Cys Gly Asp 
        195                 200                 205             


Pro His Gly Val Ser Met Phe Pro Asn Thr Leu His Glu Asp Gln Val 
    210                 215                 220                 


Arg Ser Asp Ala Ala Arg Glu Trp Leu Leu Pro Asn Tyr Gln Arg Pro 
225                 230                 235                 240 


Asn Leu Gln Val Leu Thr Gly Gln Tyr Val Gly Lys Val Leu Leu Ser 
                245                 250                 255     


Gln Asn Gly Thr Thr Pro Arg Ala Val Gly Val Glu Phe Gly Thr His 
            260                 265                 270         


Lys Gly Asn Thr His Asn Val Tyr Ala Lys His Glu Val Leu Leu Ala 
        275                 280                 285             


Ala Gly Ser Ala Val Ser Pro Thr Ile Leu Glu Tyr Ser Gly Ile Gly 
    290                 295                 300                 


Met Lys Ser Ile Leu Glu Pro Leu Gly Ile Asp Thr Val Val Asp Leu 
305                 310                 315                 320 


Pro Val Gly Leu Asn Leu Gln Asp Gln Thr Thr Ser Thr Val Arg Ser 
                325                 330                 335     


Arg Ile Thr Ser Ala Gly Ala Gly Gln Gly Gln Ala Ala Trp Phe Ala 
            340                 345                 350         


Thr Phe Asn Glu Thr Phe Gly Asp Tyr Ser Glu Lys Ala His Glu Leu 
        355                 360                 365             


Leu Asn Thr Lys Leu Glu Gln Trp Ala Glu Glu Ala Val Ala Arg Gly 
    370                 375                 380                 


Gly Phe His Asn Thr Thr Ala Leu Leu Ile Gln Tyr Glu Asn Tyr Arg 
385                 390                 395                 400 


Asp Trp Ile Val Asn His Asn Val Ala Tyr Ser Glu Leu Ile Leu Asp 
                405                 410                 415     


Thr Ala Gly Val Ala Ser Phe Asp Val Trp Asp Leu Leu Pro Phe Thr 
            420                 425                 430         


Arg Gly Tyr Val His Ile Leu Asp Lys Asp Pro Tyr Leu His His Phe 
        435                 440                 445             


Ala Tyr Asp Pro Gln Tyr Phe Leu Asn Glu Leu Asp Leu Leu Gly Gln 
    450                 455                 460                 


Ala Ala Ala Thr Gln Leu Ala Arg Asn Ile Ser Asn Ser Gly Ala Met 
465                 470                 475                 480 


Gln Thr Tyr Phe Ala Gly Glu Thr Ile Pro Gly Asp Asn Leu Ala Tyr 
                485                 490                 495     


Asp Ala Asp Leu Ser Ala Trp Thr Glu Tyr Ile Pro Tyr His Phe Arg 
            500                 505                 510         


Pro Asn Tyr His Gly Val Gly Thr Cys Ser Met Met Pro Lys Glu Met 
        515                 520                 525             


Gly Gly Val Val Asp Asn Ala Ala Arg Val Tyr Gly Val Gln Gly Leu 
    530                 535                 540                 


Arg Val Ile Asp Gly Ser Ile Pro Pro Thr Gln Met Ser Ser His Thr 
545                 550                 555                 560 


Met Thr Val Phe Tyr Ala Met Ala Leu Lys Ile Ser Asp Ala Ile Leu 
                565                 570                 575     


Glu Asp Tyr Ala Ser Met Gln 
            580             


<210>  4
<211>  583
<212>  PRT
<213>  Aspergillus niger

<400>  4

Ser Asn Gly Ile Glu Ala Ser Leu Leu Thr Asp Pro Lys Asp Val Ser 
1               5                   10                  15      


Gly Arg Thr Val Asp Tyr Ile Ile Ala Gly Gly Gly Leu Val Gly Leu 
            20                  25                  30          


Thr Thr Ala Ala Arg Leu Thr Glu Asn Pro Asn Ile Ser Val Leu Val 
        35                  40                  45              


Ile Glu Ser Gly Ser Tyr Glu Ser Asp Arg Gly Pro Ile Ile Glu Asp 
    50                  55                  60                  


Leu Asn Ala Tyr Gly Asp Ile Phe Gly Ser Ser Val Asp His Ala Tyr 
65                  70                  75                  80  


Glu Thr Val Glu Leu Ala Thr Asn Asn Gln Thr Ala Leu Val Arg Ser 
                85                  90                  95      


Gly Asn Gly Leu Gly Gly Ser Thr Leu Val Asn Gly Gly Thr Trp Thr 
            100                 105                 110         


Arg Pro His Lys Ala Gln Val Asp Ser Trp Glu Thr Val Phe Gly Asn 
        115                 120                 125             


Glu Gly Trp Asn Trp Asp Asn Val Ala Ala Tyr Ser Leu Gln Ala Glu 
    130                 135                 140                 


Arg Ala Arg Ala Pro Asn Ala Lys Gln Ile Ala Ala Gly His Tyr Phe 
145                 150                 155                 160 


Asn Ala Ser Cys His Gly Val Asn Gly Thr Val His Ile Gly Pro Arg 
                165                 170                 175     


Asp Thr Gly Asp Asp Tyr Ser Pro Ile Val Lys Ala Leu Met Ser Ala 
            180                 185                 190         


Val Glu Asp Arg Gly Val Pro Thr Lys Lys Asp Phe Gly Cys Gly Asp 
        195                 200                 205             


Pro His Gly Val Ser Met Phe Pro Asn Thr Leu His Glu Asp Gln Val 
    210                 215                 220                 


Arg Ser Asp Ala Ala Arg Glu Trp Leu Leu Pro Asn Tyr Gln Arg Pro 
225                 230                 235                 240 


Asn Leu Gln Val Leu Thr Gly Gln Tyr Val Gly Lys Val Leu Leu Ser 
                245                 250                 255     


Gln Asn Gly Thr Thr Pro Arg Ala Val Gly Val Glu Phe Gly Thr His 
            260                 265                 270         


Lys Gly Asn Thr His Asn Val Tyr Ala Lys His Glu Val Leu Leu Ala 
        275                 280                 285             


Ala Gly Ser Ala Val Ser Pro Thr Ile Leu Glu Tyr Ser Gly Ile Gly 
    290                 295                 300                 


Met Lys Ser Ile Leu Glu Pro Leu Gly Ile Asp Thr Val Val Asp Leu 
305                 310                 315                 320 


Pro Val Gly Leu Asn Leu Gln Asp Gln Thr Thr Ser Thr Val Arg Ser 
                325                 330                 335     


Arg Ile Thr Ser Ala Gly Ala Gly Gln Gly Gln Ala Ala Trp Phe Ala 
            340                 345                 350         


Thr Phe Asn Glu Thr Phe Gly Asp Tyr Ser Glu Lys Ala His Glu Leu 
        355                 360                 365             


Leu Asn Thr Lys Leu Glu Gln Trp Ala Glu Glu Ala Val Ala Arg Gly 
    370                 375                 380                 


Gly Phe His Asn Thr Thr Ala Leu Leu Ile Gln Tyr Glu Asn Tyr Arg 
385                 390                 395                 400 


Asp Trp Ile Val Asn His Asn Val Ala Tyr Ser Glu Leu Leu Leu Asp 
                405                 410                 415     


Thr Ala Gly Val Ala Ser Phe Asp Val Trp Asp Leu Leu Pro Phe Thr 
            420                 425                 430         


Arg Gly Tyr Val His Ile Leu Asp Lys Asp Pro Tyr Leu His His Phe 
        435                 440                 445             


Ala Tyr Asp Pro Gln Tyr Phe Leu Asn Glu Leu Asp Leu Leu Gly Gln 
    450                 455                 460                 


Ala Ala Ala Thr Gln Leu Ala Arg Asn Ile Ser Asn Ser Gly Ala Met 
465                 470                 475                 480 


Gln Thr Tyr Phe Ala Gly Glu Thr Ile Pro Gly Asp Asn Leu Ala Tyr 
                485                 490                 495     


Asp Ala Asp Leu Ser Ala Trp Thr Glu Tyr Ile Pro Tyr His Phe Arg 
            500                 505                 510         


Pro Asn Tyr His Gly Val Gly Thr Cys Ser Met Met Pro Lys Glu Met 
        515                 520                 525             


Gly Gly Val Val Asp Asn Ala Ala Arg Val Tyr Gly Val Gln Gly Leu 
    530                 535                 540                 


Arg Val Ile Asp Gly Ser Ile Pro Pro Thr Gln Met Ser Ser His Val 
545                 550                 555                 560 


Met Thr Val Phe Tyr Ala Met Ala Leu Lys Ile Ser Asp Ala Ile Leu 
                565                 570                 575     


Glu Asp Tyr Ala Ser Met Gln 
            580             


<210>  5
<211>  583
<212>  PRT
<213>  Aspergillus niger

<400>  5

Ser Asn Gly Ile Glu Ala Ser Leu Leu Thr Asp Pro Lys Asp Val Ser 
1               5                   10                  15      


Gly Arg Thr Val Asp Tyr Ile Ile Ala Gly Gly Gly Leu Val Gly Leu 
            20                  25                  30          


Thr Thr Ala Ala Arg Leu Thr Glu Asn Pro Asn Ile Ser Val Leu Val 
        35                  40                  45              


Ile Glu Ser Gly Ser Tyr Glu Ser Asp Arg Gly Pro Ile Ile Glu Asp 
    50                  55                  60                  


Leu Asn Ala Tyr Gly Asp Ile Phe Gly Ser Ser Val Asp His Ala Tyr 
65                  70                  75                  80  


Glu Thr Val Glu Leu Ala Thr Asn Asn Gln Thr Ala Leu Val Arg Ser 
                85                  90                  95      


Gly Asn Gly Leu Gly Gly Ser Thr Leu Val Asn Gly Gly Thr Trp Thr 
            100                 105                 110         


Arg Pro His Lys Ala Gln Val Asp Ser Trp Glu Thr Val Phe Gly Asn 
        115                 120                 125             


Glu Gly Trp Asn Trp Asp Asn Val Ala Ala Tyr Ser Leu Gln Ala Glu 
    130                 135                 140                 


Arg Ala Arg Ala Pro Asn Ala Lys Gln Ile Ala Ala Gly His Tyr Phe 
145                 150                 155                 160 


Asn Ala Ser Cys His Gly Val Asn Gly Thr Val His Val Gly Pro Arg 
                165                 170                 175     


Asp Thr Gly Asp Asp Tyr Ser Pro Ile Val Lys Ala Leu Met Ser Ala 
            180                 185                 190         


Val Glu Asp Arg Gly Val Pro Thr Lys Lys Asp Phe Gly Cys Gly Asp 
        195                 200                 205             


Pro His Gly Val Ser Met Phe Pro Asn Thr Leu His Glu Asp Gln Val 
    210                 215                 220                 


Arg Ser Asp Ala Ala Arg Glu Trp Leu Leu Pro Asn Tyr Gln Arg Pro 
225                 230                 235                 240 


Asn Leu Gln Val Leu Thr Gly Gln Tyr Val Gly Lys Val Leu Leu Ser 
                245                 250                 255     


Gln Asn Gly Thr Thr Pro Arg Ala Val Gly Val Glu Phe Gly Thr His 
            260                 265                 270         


Lys Gly Asn Thr His Asn Val Tyr Ala Lys His Glu Val Leu Leu Ala 
        275                 280                 285             


Ala Gly Ser Ala Val Ser Pro Thr Ile Leu Glu Tyr Ser Gly Ile Gly 
    290                 295                 300                 


Met Lys Ser Ile Leu Glu Pro Leu Gly Ile Asp Thr Val Val Asp Leu 
305                 310                 315                 320 


Pro Val Gly Leu Asn Leu Gln Asp Gln Thr Thr Asn Thr Val Arg Ser 
                325                 330                 335     


Arg Ile Thr Ser Ala Gly Ala Gly Gln Gly Gln Ala Ala Trp Phe Ala 
            340                 345                 350         


Thr Phe Asn Glu Thr Phe Gly Asp Tyr Ser Glu Lys Ala His Glu Leu 
        355                 360                 365             


Leu Asn Thr Lys Leu Glu Gln Trp Ala Glu Glu Ala Val Ala Arg Gly 
    370                 375                 380                 


Gly Phe His Asn Thr Thr Ala Leu Leu Ile Gln Tyr Glu Asn Tyr Arg 
385                 390                 395                 400 


Asp Trp Ile Val Asn His Asn Val Ala Tyr Ser Glu Leu Phe Leu Asp 
                405                 410                 415     


Thr Ala Gly Val Ala Ser Phe Asp Val Trp Asp Leu Leu Pro Phe Thr 
            420                 425                 430         


Arg Gly Tyr Val His Ile Leu Asp Lys Asp Pro Tyr Leu His His Phe 
        435                 440                 445             


Ala Tyr Asp Pro Gln Tyr Phe Leu Asn Glu Leu Asp Leu Leu Gly Gln 
    450                 455                 460                 


Ala Ala Ala Thr Gln Leu Ala Arg Asn Ile Ser Asn Ser Gly Ala Met 
465                 470                 475                 480 


Gln Thr Tyr Phe Ala Gly Glu Thr Ile Pro Gly Asp Asn Leu Ala Tyr 
                485                 490                 495     


Asp Ala Asp Leu Ser Ala Trp Thr Glu Tyr Ile Pro Tyr His Phe Arg 
            500                 505                 510         


Pro Asn Tyr His Gly Val Gly Thr Cys Ser Met Met Pro Lys Glu Met 
        515                 520                 525             


Gly Gly Val Val Asp Asn Ala Ala Arg Val Tyr Gly Val Gln Gly Leu 
    530                 535                 540                 


Arg Val Ile Asp Gly Ser Ile Pro Pro Thr Gln Met Ser Ser His Pro 
545                 550                 555                 560 


Met Thr Val Phe Tyr Ala Met Ala Leu Lys Ile Ser Asp Ala Ile Leu 
                565                 570                 575     


Glu Asp Tyr Ala Ser Met Gln 
            580             


<210>  6
<211>  583
<212>  PRT
<213>  Aspergillus niger

<400>  6

Ser Asn Gly Ile Glu Ala Ser Leu Leu Thr Asp Pro Lys Asp Val Ser 
1               5                   10                  15      


Gly Arg Thr Val Asp Tyr Ile Ile Ala Gly Gly Gly Leu Val Gly Leu 
            20                  25                  30          


Thr Thr Ala Ala Arg Leu Thr Glu Asn Pro Asn Ile Ser Val Leu Val 
        35                  40                  45              


Ile Glu Ser Gly Ser Tyr Glu Ser Asp Arg Gly Pro Ile Ile Glu Asp 
    50                  55                  60                  


Leu Asn Ala Tyr Gly Asp Ile Phe Gly Ser Ser Val Asp His Ala Tyr 
65                  70                  75                  80  


Glu Thr Val Glu Leu Ala Thr Asn Asn Gln Thr Ala Leu Val Arg Ser 
                85                  90                  95      


Gly Asn Gly Leu Gly Gly Ser Thr Leu Val Asn Gly Gly Thr Trp Thr 
            100                 105                 110         


Arg Pro His Lys Ala Gln Val Asp Ser Trp Glu Thr Val Phe Gly Asn 
        115                 120                 125             


Glu Gly Trp Asn Trp Asp Asn Val Ala Ala Tyr Ser Leu Gln Ala Glu 
    130                 135                 140                 


Arg Ala Arg Ala Pro Asn Ala Lys Gln Ile Ala Ala Gly His Tyr Phe 
145                 150                 155                 160 


Asn Ala Ser Cys His Gly Val Asn Gly Thr Val His Val Gly Pro Arg 
                165                 170                 175     


Asp Thr Gly Asp Asp Tyr Ser Pro Ile Val Lys Ala Leu Met Ser Ala 
            180                 185                 190         


Val Glu Asp Arg Gly Val Pro Thr Lys Lys Asp Phe Gly Cys Gly Asp 
        195                 200                 205             


Pro His Gly Val Ser Met Phe Pro Asn Thr Leu His Glu Asp Gln Val 
    210                 215                 220                 


Arg Ser Asp Ala Ala Arg Glu Trp Leu Leu Pro Asn Tyr Gln Arg Pro 
225                 230                 235                 240 


Asn Leu Gln Val Leu Thr Gly Gln Tyr Val Gly Lys Val Leu Leu Ser 
                245                 250                 255     


Gln Asn Gly Thr Thr Pro Arg Ala Val Gly Val Glu Phe Gly Thr His 
            260                 265                 270         


Lys Gly Asn Thr His Asn Val Tyr Ala Lys His Glu Val Leu Leu Ala 
        275                 280                 285             


Ala Gly Ser Ala Val Ser Pro Thr Ile Leu Glu Tyr Ser Gly Ile Gly 
    290                 295                 300                 


Met Lys Ser Ile Leu Glu Pro Leu Gly Ile Asp Thr Val Val Asp Leu 
305                 310                 315                 320 


Pro Val Gly Leu Asn Leu Gln Asp Gln Thr Thr Asn Thr Val Arg Ser 
                325                 330                 335     


Arg Ile Thr Ser Ala Gly Ala Gly Gln Gly Gln Ala Ala Trp Phe Ala 
            340                 345                 350         


Thr Phe Asn Glu Thr Phe Gly Asp Tyr Ser Glu Lys Ala His Glu Leu 
        355                 360                 365             


Leu Asn Thr Lys Leu Glu Gln Trp Ala Glu Glu Ala Val Ala Arg Gly 
    370                 375                 380                 


Gly Phe His Asn Thr Thr Ala Leu Leu Ile Gln Tyr Glu Asn Tyr Arg 
385                 390                 395                 400 


Asp Trp Ile Val Asn His Asn Val Ala Tyr Ser Glu Leu Val Leu Asp 
                405                 410                 415     


Thr Ala Gly Val Ala Ser Phe Asp Val Trp Asp Leu Leu Pro Phe Thr 
            420                 425                 430         


Arg Gly Tyr Val His Ile Leu Asp Lys Asp Pro Tyr Leu His His Phe 
        435                 440                 445             


Ala Tyr Asp Pro Gln Tyr Phe Leu Asn Glu Leu Asp Leu Leu Gly Gln 
    450                 455                 460                 


Ala Ala Ala Thr Gln Leu Ala Arg Asn Ile Ser Asn Ser Gly Ala Met 
465                 470                 475                 480 


Gln Thr Tyr Phe Ala Gly Glu Thr Ile Pro Gly Asp Asn Leu Ala Tyr 
                485                 490                 495     


Asp Ala Asp Leu Ser Ala Trp Thr Glu Tyr Ile Pro Tyr His Phe Arg 
            500                 505                 510         


Pro Asn Tyr His Gly Val Gly Thr Cys Ser Met Met Pro Lys Glu Met 
        515                 520                 525             


Gly Gly Val Val Asp Asn Ala Ala Arg Val Tyr Gly Val Gln Gly Leu 
    530                 535                 540                 


Arg Val Ile Asp Gly Ser Ile Pro Pro Thr Gln Met Ser Ser His Leu 
545                 550                 555                 560 


Met Thr Val Phe Tyr Ala Met Ala Leu Lys Ile Ser Asp Ala Ile Leu 
                565                 570                 575     


Glu Asp Tyr Ala Ser Met Gln 
            580             


<210>  7
<211>  583
<212>  PRT
<213>  Aspergillus niger

<400>  7

Ser Asn Gly Ile Glu Ala Ser Leu Leu Thr Asp Pro Lys Asp Val Ser 
1               5                   10                  15      


Gly Arg Thr Val Asp Tyr Ile Ile Ala Gly Gly Gly Leu Val Gly Leu 
            20                  25                  30          


Thr Thr Ala Ala Arg Leu Thr Glu Asn Pro Asn Ile Ser Val Leu Val 
        35                  40                  45              


Ile Glu Ser Gly Ser Tyr Glu Ser Asp Arg Gly Pro Ile Ile Glu Asp 
    50                  55                  60                  


Leu Asn Ala Tyr Gly Asp Ile Phe Gly Ser Ser Val Asp His Ala Tyr 
65                  70                  75                  80  


Glu Thr Val Glu Leu Ala Thr Asn Asn Gln Thr Ala Leu Val Arg Ser 
                85                  90                  95      


Gly Asn Gly Leu Gly Gly Ser Thr Leu Val Asn Gly Gly Thr Trp Thr 
            100                 105                 110         


Arg Pro His Lys Ala Gln Val Asp Ser Trp Glu Thr Val Phe Gly Asn 
        115                 120                 125             


Glu Gly Trp Asn Trp Asp Asn Val Ala Ala Tyr Ser Leu Gln Ala Glu 
    130                 135                 140                 


Arg Ala Arg Ala Pro Asn Ala Lys Gln Ile Ala Ala Gly His Tyr Phe 
145                 150                 155                 160 


Asn Ala Ser Cys His Gly Val Asn Gly Thr Val His Ala Gly Pro Arg 
                165                 170                 175     


Asp Thr Gly Asp Asp Tyr Ser Pro Ile Val Lys Ala Leu Met Ser Ala 
            180                 185                 190         


Val Glu Asp Arg Gly Val Pro Thr Lys Lys Asp Phe Gly Cys Gly Asp 
        195                 200                 205             


Pro His Gly Val Ser Met Phe Pro Asn Thr Leu His Glu Asp Gln Val 
    210                 215                 220                 


Arg Ser Asp Ala Ala Arg Glu Trp Leu Leu Pro Asn Tyr Gln Arg Pro 
225                 230                 235                 240 


Asn Leu Gln Val Leu Thr Gly Gln Tyr Val Gly Lys Val Leu Leu Ser 
                245                 250                 255     


Gln Asn Gly Thr Thr Pro Arg Ala Val Gly Val Glu Phe Gly Thr His 
            260                 265                 270         


Lys Gly Asn Thr His Asn Val Tyr Ala Lys His Glu Val Leu Leu Ala 
        275                 280                 285             


Ala Gly Ser Ala Val Ser Pro Thr Ile Leu Glu Tyr Ser Gly Ile Gly 
    290                 295                 300                 


Met Lys Ser Ile Leu Glu Pro Leu Gly Ile Asp Thr Val Val Asp Leu 
305                 310                 315                 320 


Pro Val Gly Leu Asn Leu Gln Asp Gln Thr Thr Ser Thr Val Arg Ser 
                325                 330                 335     


Arg Ile Thr Ser Ala Gly Ala Gly Gln Gly Gln Ala Ala Trp Phe Ala 
            340                 345                 350         


Thr Phe Asn Glu Thr Phe Gly Asp Tyr Ser Glu Lys Ala His Glu Leu 
        355                 360                 365             


Leu Asn Thr Lys Leu Glu Gln Trp Ala Glu Glu Ala Val Ala Arg Gly 
    370                 375                 380                 


Gly Phe His Asn Thr Thr Ala Leu Leu Ile Gln Tyr Glu Asn Tyr Arg 
385                 390                 395                 400 


Asp Trp Ile Val Asn His Asn Val Ala Tyr Ser Glu Leu Phe Leu Asp 
                405                 410                 415     


Thr Ala Gly Val Ala Ser Phe Asp Val Trp Asp Leu Leu Pro Phe Thr 
            420                 425                 430         


Arg Gly Tyr Val His Ile Leu Asp Lys Asp Pro Tyr Leu His His Phe 
        435                 440                 445             


Ala Tyr Asp Pro Gln Tyr Phe Leu Asn Glu Leu Asp Leu Leu Gly Gln 
    450                 455                 460                 


Ala Ala Ala Thr Gln Leu Ala Arg Asn Ile Ser Asn Ser Gly Ala Met 
465                 470                 475                 480 


Gln Thr Tyr Phe Ala Gly Glu Thr Ile Pro Gly Asp Asn Leu Ala Tyr 
                485                 490                 495     


Asp Ala Asp Leu Ser Ala Trp Thr Glu Tyr Ile Pro Tyr His Phe Arg 
            500                 505                 510         


Pro Asn Tyr His Gly Val Gly Thr Cys Ser Met Met Pro Lys Glu Met 
        515                 520                 525             


Gly Gly Val Val Asp Asn Ala Ala Arg Val Tyr Gly Val Gln Gly Leu 
    530                 535                 540                 


Arg Val Ile Asp Gly Ser Ile Pro Pro Thr Gln Met Ser Ser His Pro 
545                 550                 555                 560 


Met Thr Val Phe Tyr Ala Met Ala Leu Lys Ile Ser Asp Ala Ile Leu 
                565                 570                 575     


Glu Asp Tyr Ala Ser Met Gln 
            580             


<210>  8
<211>  583
<212>  PRT
<213>  Aspergillus niger

<400>  8

Ser Asn Gly Ile Glu Ala Ser Leu Leu Thr Asp Pro Lys Asp Val Ser 
1               5                   10                  15      


Gly Arg Thr Val Asp Tyr Ile Ile Ala Gly Gly Gly Leu Val Gly Leu 
            20                  25                  30          


Thr Thr Ala Ala Arg Leu Thr Glu Asn Pro Asn Ile Ser Val Leu Val 
        35                  40                  45              


Ile Glu Ser Gly Phe Tyr Glu Ser Asp Arg Gly Pro Ile Ile Glu Asp 
    50                  55                  60                  


Leu Asn Ala Tyr Gly Asp Ile Phe Gly Ser Ser Val Asp His Ala Tyr 
65                  70                  75                  80  


Glu Thr Val Glu Leu Ala Thr Asn Asn Gln Thr Ala Leu Val Arg Ser 
                85                  90                  95      


Gly Asn Gly Leu Gly Gly Ser Thr Leu Val Asn Gly Gly Thr Trp Thr 
            100                 105                 110         


Arg Pro His Lys Ala Gln Val Asp Ser Trp Glu Thr Val Phe Gly Asn 
        115                 120                 125             


Glu Gly Trp Asn Trp Asp Asn Val Ala Ala Tyr Ser Leu Gln Ala Glu 
    130                 135                 140                 


Arg Ala Arg Ala Pro Asn Ala Lys Gln Ile Ala Ala Gly His Tyr Phe 
145                 150                 155                 160 


Asn Ala Ser Cys His Gly Val Asn Gly Thr Val His Ala Gly Pro Arg 
                165                 170                 175     


Asp Thr Gly Asp Asp Tyr Ser Pro Ile Val Lys Ala Leu Met Ser Ala 
            180                 185                 190         


Val Glu Asp Arg Gly Val Pro Thr Lys Lys Asp Phe Gly Cys Gly Asp 
        195                 200                 205             


Pro His Gly Val Ser Met Phe Pro Asn Thr Leu His Glu Asp Gln Val 
    210                 215                 220                 


Arg Ser Asp Ala Ala Arg Glu Trp Leu Leu Pro Asn Tyr Gln Arg Pro 
225                 230                 235                 240 


Asn Leu Gln Val Leu Thr Gly Gln Tyr Val Gly Lys Val Leu Leu Ser 
                245                 250                 255     


Gln Asn Gly Thr Thr Pro Arg Ala Val Gly Val Glu Phe Gly Thr His 
            260                 265                 270         


Lys Gly Asn Thr His Asn Val Tyr Ala Lys His Glu Val Leu Leu Ala 
        275                 280                 285             


Ala Gly Ser Ala Val Ser Pro Thr Ile Leu Glu Tyr Ser Gly Ile Gly 
    290                 295                 300                 


Met Lys Ser Ile Leu Glu Pro Leu Gly Ile Asp Thr Val Val Asp Leu 
305                 310                 315                 320 


Pro Val Gly Leu Asn Leu Gln Asp Gln Thr Thr Ser Thr Val Arg Ser 
                325                 330                 335     


Arg Ile Thr Ser Ala Gly Ala Gly Gln Gly Gln Ala Ala Trp Phe Ala 
            340                 345                 350         


Thr Phe Asn Glu Thr Phe Gly Asp Tyr Ser Glu Lys Ala His Glu Leu 
        355                 360                 365             


Leu Asn Thr Lys Leu Glu Gln Trp Ala Glu Glu Ala Val Ala Arg Gly 
    370                 375                 380                 


Gly Phe His Asn Thr Thr Ala Leu Leu Ile Gln Tyr Glu Asn Tyr Arg 
385                 390                 395                 400 


Asp Trp Ile Val Asn His Asn Val Ala Tyr Ser Glu Leu Phe Leu Asp 
                405                 410                 415     


Thr Ala Gly Val Ala Ser Phe Asp Val Trp Asp Leu Leu Pro Phe Thr 
            420                 425                 430         


Arg Gly Tyr Val His Ile Leu Asp Lys Asp Pro Tyr Leu His His Phe 
        435                 440                 445             


Ala Tyr Asp Pro Gln Tyr Phe Leu Asn Glu Leu Asp Leu Leu Gly Gln 
    450                 455                 460                 


Ala Ala Ala Thr Gln Leu Ala Arg Asn Ile Ser Asn Ser Gly Ala Met 
465                 470                 475                 480 


Gln Thr Tyr Phe Ala Gly Glu Thr Ile Pro Gly Asp Asn Leu Ala Tyr 
                485                 490                 495     


Asp Ala Asp Leu Ser Ala Trp Thr Glu Tyr Ile Pro Tyr His Phe Arg 
            500                 505                 510         


Pro Asn Tyr His Gly Val Gly Thr Cys Ser Met Met Pro Lys Glu Met 
        515                 520                 525             


Gly Gly Val Val Asp Asn Ala Ala Arg Val Tyr Gly Val Gln Gly Leu 
    530                 535                 540                 


Arg Val Ile Asp Gly Ser Ile Pro Pro Thr Gln Met Ser Ser His Val 
545                 550                 555                 560 


Met Thr Val Phe Tyr Ala Met Ala Leu Lys Ile Ser Asp Ala Ile Leu 
                565                 570                 575     


Glu Asp Tyr Ala Ser Met Gln 
            580             


<210>  9
<211>  583
<212>  PRT
<213>  Aspergillus niger

<400>  9

Ser Asn Gly Ile Glu Ala Ser Leu Leu Thr Asp Pro Lys Asp Val Ser 
1               5                   10                  15      


Gly Arg Thr Val Asp Tyr Ile Ile Ala Gly Gly Gly Leu Val Gly Leu 
            20                  25                  30          


Thr Thr Ala Ala Arg Leu Thr Glu Asn Pro Asn Ile Ser Val Leu Val 
        35                  40                  45              


Ile Glu Ser Gly Ser Tyr Glu Ser Asp Arg Gly Pro Ile Ile Glu Asp 
    50                  55                  60                  


Leu Asn Ala Tyr Gly Asp Ile Phe Gly Ser Ser Val Asp His Ala Tyr 
65                  70                  75                  80  


Glu Thr Val Glu Leu Ala Thr Asn Asn Gln Thr Ala Leu Val Arg Ser 
                85                  90                  95      


Gly Asn Gly Leu Gly Gly Ser Thr Leu Val Asn Gly Gly Thr Trp Thr 
            100                 105                 110         


Arg Pro His Lys Ala Gln Val Asp Ser Trp Glu Thr Val Phe Gly Asn 
        115                 120                 125             


Glu Gly Trp Asn Trp Asp Asn Val Leu Ala Tyr Ser Leu Gln Ala Glu 
    130                 135                 140                 


Arg Ala Arg Ala Pro Asn Ala Lys Gln Ile Ala Ala Gly His Tyr Phe 
145                 150                 155                 160 


Asn Ala Ser Cys His Gly Val Asn Gly Thr Val His Ala Gly Pro Arg 
                165                 170                 175     


Asp Thr Gly Asp Asp Tyr Ser Pro Ile Val Lys Ala Leu Met Ser Ala 
            180                 185                 190         


Val Glu Asp Arg Gly Val Pro Thr Lys Lys Asp Phe Gly Cys Gly Asp 
        195                 200                 205             


Pro His Gly Val Ser Met Phe Pro Asn Thr Leu His Glu Asp Gln Val 
    210                 215                 220                 


Arg Ser Asp Ala Ala Arg Glu Trp Leu Leu Pro Asn Tyr Gln Arg Pro 
225                 230                 235                 240 


Asn Leu Gln Val Leu Thr Gly Gln Tyr Val Gly Lys Val Leu Leu Ser 
                245                 250                 255     


Gln Asn Gly Thr Thr Pro Arg Ala Val Gly Val Glu Phe Gly Thr His 
            260                 265                 270         


Lys Gly Asn Thr His Asn Val Tyr Ala Lys His Glu Val Leu Leu Ala 
        275                 280                 285             


Ala Gly Ser Ala Val Ser Pro Thr Ile Leu Glu Tyr Ser Gly Ile Gly 
    290                 295                 300                 


Met Lys Ser Ile Leu Glu Pro Leu Gly Ile Asp Thr Val Val Asp Leu 
305                 310                 315                 320 


Pro Val Gly Leu Asn Leu Gln Asp Gln Thr Thr Ala Thr Val Arg Ser 
                325                 330                 335     


Arg Ile Thr Ser Ala Gly Ala Gly Gln Gly Gln Ala Ala Trp Phe Ala 
            340                 345                 350         


Thr Phe Asn Glu Thr Phe Gly Asp Tyr Ser Glu Lys Ala His Glu Leu 
        355                 360                 365             


Leu Asn Thr Lys Leu Glu Gln Trp Ala Glu Glu Ala Val Ala Arg Gly 
    370                 375                 380                 


Gly Phe His Asn Thr Thr Ala Leu Leu Ile Gln Tyr Glu Asn Tyr Arg 
385                 390                 395                 400 


Asp Trp Ile Val Asn His Asn Val Ala Tyr Ser Glu Leu Phe Leu Asp 
                405                 410                 415     


Thr Ala Gly Val Ala Ser Phe Asp Val Trp Asp Leu Leu Pro Phe Thr 
            420                 425                 430         


Arg Gly Tyr Val His Ile Leu Asp Lys Asp Pro Tyr Leu His His Phe 
        435                 440                 445             


Ala Tyr Asp Pro Gln Tyr Phe Leu Asn Glu Leu Asp Leu Leu Gly Gln 
    450                 455                 460                 


Ala Ala Ala Thr Gln Leu Ala Arg Asn Ile Ser Asn Ser Gly Ala Met 
465                 470                 475                 480 


Gln Thr Tyr Phe Ala Gly Glu Thr Ile Pro Gly Asp Asn Leu Ala Tyr 
                485                 490                 495     


Asp Ala Asp Leu Ser Ala Trp Thr Glu Tyr Ile Pro Tyr His Phe Arg 
            500                 505                 510         


Pro Asn Tyr His Gly Val Gly Thr Cys Ser Met Met Pro Lys Glu Met 
        515                 520                 525             


Gly Gly Val Val Asp Asn Ala Ala Arg Val Tyr Gly Val Gln Gly Leu 
    530                 535                 540                 


Arg Val Ile Asp Gly Ser Ile Pro Pro Thr Gln Met Ser Ser His Val 
545                 550                 555                 560 


Met Thr Val Phe Tyr Ala Met Ala Leu Lys Ile Ser Asp Ala Ile Leu 
                565                 570                 575     


Glu Asp Tyr Ala Ser Met Gln 
            580             


<210>  10
<211>  1749
<212>  DNA
<213>  Aspergillus niger

<400>  10
agcaatggca ttgaagccag cctcctgact gatcccaagg atgtctccgg ccgcacggtc     60

gactacatca tcgctggtgg aggtctggtt ggactcacca ccgctgctcg tctgacggag    120

aaccccaaca tcagtgtgct cgtcatcgaa agtggctcct acgagtcgga cagaggtcct    180

atcattgagg acctgaacgc ctacggcgac atctttggca gcagtgtaga ccacgcctac    240

gagaccgtgg agctcgctac caacaatcaa accgcgctgg tccgctccgg aaatggtctc    300

ggtggctcta ctctagtgaa tggtggcacc tggactcgcc cccacaaggc acaggttgac    360

tcttgggaga ctgtctttgg aaatgagggc tggaactggg acaatgtggc cgcctactcc    420

ctccaggctg agcgtgctcg cgcaccaaat gccaaacaga tcgctgctgg ccactacttc    480

aacgcatcct gccatggtgt taatggtact gtccatgccg gaccccgcga caccggcgat    540

gactattctc ccatcgtcaa ggctctcatg agcgctgtcg aagaccgggg cgttcccacc    600

aagaaagact tcggatgcgg tgacccccat ggtgtgtcca tgttccccaa caccttgcac    660

gaagaccaag tgcgctccga tgccgctcgc gaatggctac ttcccaacta ccaacgtccc    720

aacctgcaag tcctgaccgg acagtatgtt ggtaaggtgc tccttagcca gaacggcacc    780

acccctcgtg ccgttggcgt ggaattcggc acccacaagg gcaacaccca caacgtttac    840

gctaagcacg aggtcctcct ggccgcgggc tccgctgtct ctcccacaat cctcgaatat    900

tccggtatcg gaatgaagtc catcctggag ccccttggta tcgacaccgt cgttgacctg    960

cccgtcggct tgaacctgca ggaccagacc accgctaccg tccgctcccg catcacctct   1020

gctggtgcag gacagggaca ggccgcttgg ttcgccacct tcaacgagac ctttggtgac   1080

tattccgaaa aggcacacga gctgctcaac accaagctgg agcagtgggc cgaagaggcc   1140

gtcgcccgtg gcggattcca caacaccacc gccttgctca tccagtacga gaactaccgc   1200

gactggattg tcaaccacaa cgtcgcgtac tcggaactct tcctcgacac tgccggagta   1260

gccagcttcg atgtgtggga ccttctgccc ttcacccgag gatacgttca catcctcgac   1320

aaggacccct accttcacca cttcgcctac gaccctcagt acttcctcaa cgagctggac   1380

ctgctcggtc aggctgccgc tactcaactg gcccgcaaca tctccaactc cggtgccatg   1440

cagacctact tcgctgggga gactatcccc ggtgataacc tcgcgtatga tgccgatttg   1500

agcgcctgga ctgagtacat cccgtaccac ttccgtccta actaccatgg cgtgggtact   1560

tgctccatga tgccgaagga gatgggcggt gttgttgata atgctgcccg tgtgtatggt   1620

gtgcagggac tgcgtgtcat tgatggttct attcctccta cgcaaatgtc gtcccatgtc   1680

atgacggtgt tctatgccat ggcgctaaaa atttcggatg ctatcttgga agattatgct   1740

tccatgcag                                                           1749


<210>  11
<211>  1749
<212>  DNA
<213>  Aspergillus niger

<400>  11
agcaatggca ttgaagccag cctcctgact gatcccaagg atgtctccgg ccgcacggtc     60

gactacatca tcgctggtgg aggtctggtt ggactcacca ccgctgctcg tctgacggag    120

aaccccaaca tcagtgtgct cgtcatcgaa agtggctcct acgagtcgga cagaggtcct    180

atcattgagg acctgaacgc ctacggcgac atctttggca gcagtgtaga ccacgcctac    240

gagaccgtgg agctcgctac caacaatcaa accgcgctgg tccgctccgg aaatggtctc    300

ggtggctcta ctctagtgaa tggtggcacc tggactcgcc cccacaaggc acaggttgac    360

tcttgggaga ctgtctttgg aaatgagggc tggaactggg acaatgtggc cgcctactcc    420

ctccaggctg agcgtgctcg cgcaccaaat gccaaacaga tcgctgctgg ccactacttc    480

aacgcatcct gccatggtgt taatggtact gtccatgttg gaccccgcga caccggcgat    540

gactattctc ccatcgtcaa ggctctcatg agcgctgtcg aagaccgggg cgttcccacc    600

aagaaagact tcggatgcgg tgacccccat ggtgtgtcca tgttccccaa caccttgcac    660

gaagaccaag tgcgctccga tgccgctcgc gaatggctac ttcccaacta ccaacgtccc    720

aacctgcaag tcctgaccgg acagtatgtt ggtaaggtgc tccttagcca gaacggcacc    780

acccctcgtg ccgttggcgt ggaattcggc acccacaagg gcaacaccca caacgtttac    840

gctaagcacg aggtcctcct ggccgcgggc tccgctgtct ctcccacaat cctcgaatat    900

tccggtatcg gaatgaagtc catcctggag ccccttggta tcgacaccgt cgttgacctg    960

cccgtcggct tgaacctgca ggaccagacc accagtaccg tccgctcccg catcacctct   1020

gctggtgcag gacagggaca ggccgcttgg ttcgccacct tcaacgagac ctttggtgac   1080

tattccgaaa aggcacacga gctgctcaac accaagctgg agcagtgggc cgaagaggcc   1140

gtcgcccgtg gcggattcca caacaccacc gccttgctca tccagtacga gaactaccgc   1200

gactggattg tcaaccacaa cgtcgcgtac tcggaactca ttctcgacac tgccggagta   1260

gccagcttcg atgtgtggga ccttctgccc ttcacccgag gatacgttca catcctcgac   1320

aaggacccct accttcacca cttcgcctac gaccctcagt acttcctcaa cgagctggac   1380

ctgctcggtc aggctgccgc tactcaactg gcccgcaaca tctccaactc cggtgccatg   1440

cagacctact tcgctgggga gactatcccc ggtgataacc tcgcgtatga tgccgatttg   1500

agcgcctgga ctgagtacat cccgtaccac ttccgtccta actaccatgg cgtgggtact   1560

tgctccatga tgccgaagga gatgggcggt gttgttgata atgctgcccg tgtgtatggt   1620

gtgcagggac tgcgtgtcat tgatggttct attcctccta cgcaaatgtc gtcccatacg   1680

atgacggtgt tctatgccat ggcgctaaaa atttcggatg ctatcttgga agattatgct   1740

tccatgcag                                                           1749


<210>  12
<211>  1749
<212>  DNA
<213>  Aspergillus niger

<400>  12
agcaatggca ttgaagccag cctcctgact gatcccaagg atgtctccgg ccgcacggtc     60

gactacatca tcgctggtgg aggtctggtt ggactcacca ccgctgctcg tctgacggag    120

aaccccaaca tcagtgtgct cgtcatcgaa agtggctcct acgagtcgga cagaggtcct    180

atcattgagg acctgaacgc ctacggcgac atctttggca gcagtgtaga ccacgcctac    240

gagaccgtgg agctcgctac caacaatcaa accgcgctgg tccgctccgg aaatggtctc    300

ggtggctcta ctctagtgaa tggtggcacc tggactcgcc cccacaaggc acaggttgac    360

tcttgggaga ctgtctttgg aaatgagggc tggaactggg acaatgtggc cgcctactcc    420

ctccaggctg agcgtgctcg cgcaccaaat gccaaacaga tcgctgctgg ccactacttc    480

aacgcatcct gccatggtgt taatggtact gtccatattg gaccccgcga caccggcgat    540

gactattctc ccatcgtcaa ggctctcatg agcgctgtcg aagaccgggg cgttcccacc    600

aagaaagact tcggatgcgg tgacccccat ggtgtgtcca tgttccccaa caccttgcac    660

gaagaccaag tgcgctccga tgccgctcgc gaatggctac ttcccaacta ccaacgtccc    720

aacctgcaag tcctgaccgg acagtatgtt ggtaaggtgc tccttagcca gaacggcacc    780

acccctcgtg ccgttggcgt ggaattcggc acccacaagg gcaacaccca caacgtttac    840

gctaagcacg aggtcctcct ggccgcgggc tccgctgtct ctcccacaat cctcgaatat    900

tccggtatcg gaatgaagtc catcctggag ccccttggta tcgacaccgt cgttgacctg    960

cccgtcggct tgaacctgca ggaccagacc accagtaccg tccgctcccg catcacctct   1020

gctggtgcag gacagggaca ggccgcttgg ttcgccacct tcaacgagac ctttggtgac   1080

tattccgaaa aggcacacga gctgctcaac accaagctgg agcagtgggc cgaagaggcc   1140

gtcgcccgtg gcggattcca caacaccacc gccttgctca tccagtacga gaactaccgc   1200

gactggattg tcaaccacaa cgtcgcgtac tcggaactcc ttctcgacac tgccggagta   1260

gccagcttcg atgtgtggga ccttctgccc ttcacccgag gatacgttca catcctcgac   1320

aaggacccct accttcacca cttcgcctac gaccctcagt acttcctcaa cgagctggac   1380

ctgctcggtc aggctgccgc tactcaactg gcccgcaaca tctccaactc cggtgccatg   1440

cagacctact tcgctgggga gactatcccc ggtgataacc tcgcgtatga tgccgatttg   1500

agcgcctgga ctgagtacat cccgtaccac ttccgtccta actaccatgg cgtgggtact   1560

tgctccatga tgccgaagga gatgggcggt gttgttgata atgctgcccg tgtgtatggt   1620

gtgcagggac tgcgtgtcat tgatggttct attcctccta cgcaaatgtc gtcccatgtc   1680

atgacggtgt tctatgccat ggcgctaaaa atttcggatg ctatcttgga agattatgct   1740

tccatgcag                                                           1749


<210>  13
<211>  1749
<212>  DNA
<213>  Aspergillus niger

<400>  13
agcaatggca ttgaagccag cctcctgact gatcccaagg atgtctccgg ccgcacggtc     60

gactacatca tcgctggtgg aggtctggtt ggactcacca ccgctgctcg tctgacggag    120

aaccccaaca tcagtgtgct cgtcatcgaa agtggctcct acgagtcgga cagaggtcct    180

atcattgagg acctgaacgc ctacggcgac atctttggca gcagtgtaga ccacgcctac    240

gagaccgtgg agctcgctac caacaatcaa accgcgctgg tccgctccgg aaatggtctc    300

ggtggctcta ctctagtgaa tggtggcacc tggactcgcc cccacaaggc acaggttgac    360

tcttgggaga ctgtctttgg aaatgagggc tggaactggg acaatgtggc cgcctactcc    420

ctccaggctg agcgtgctcg cgcaccaaat gccaaacaga tcgctgctgg ccactacttc    480

aacgcatcct gccatggtgt taatggtact gtccatgttg gaccccgcga caccggcgat    540

gactattctc ccatcgtcaa ggctctcatg agcgctgtcg aagaccgggg cgttcccacc    600

aagaaagact tcggatgcgg tgacccccat ggtgtgtcca tgttccccaa caccttgcac    660

gaagaccaag tgcgctccga tgccgctcgc gaatggctac ttcccaacta ccaacgtccc    720

aacctgcaag tcctgaccgg acagtatgtt ggtaaggtgc tccttagcca gaacggcacc    780

acccctcgtg ccgttggcgt ggaattcggc acccacaagg gcaacaccca caacgtttac    840

gctaagcacg aggtcctcct ggccgcgggc tccgctgtct ctcccacaat cctcgaatat    900

tccggtatcg gaatgaagtc catcctggag ccccttggta tcgacaccgt cgttgacctg    960

cccgtcggct tgaacctgca ggaccagacc accaataccg tccgctcccg catcacctct   1020

gctggtgcag gacagggaca ggccgcttgg ttcgccacct tcaacgagac ctttggtgac   1080

tattccgaaa aggcacacga gctgctcaac accaagctgg agcagtgggc cgaagaggcc   1140

gtcgcccgtg gcggattcca caacaccacc gccttgctca tccagtacga gaactaccgc   1200

gactggattg tcaaccacaa cgtcgcgtac tcggaactct ttctcgacac tgccggagta   1260

gccagcttcg atgtgtggga ccttctgccc ttcacccgag gatacgttca catcctcgac   1320

aaggacccct accttcacca cttcgcctac gaccctcagt acttcctcaa cgagctggac   1380

ctgctcggtc aggctgccgc tactcaactg gcccgcaaca tctccaactc cggtgccatg   1440

cagacctact tcgctgggga gactatcccc ggtgataacc tcgcgtatga tgccgatttg   1500

agcgcctgga ctgagtacat cccgtaccac ttccgtccta actaccatgg cgtgggtact   1560

tgctccatga tgccgaagga gatgggcggt gttgttgata atgctgcccg tgtgtatggt   1620

gtgcagggac tgcgtgtcat tgatggttct attcctccta cgcaaatgtc gtcccatccg   1680

atgacggtgt tctatgccat ggcgctaaaa atttcggatg ctatcttgga agattatgct   1740

tccatgcag                                                           1749


<210>  14
<211>  1704
<212>  DNA
<213>  Aspergillus niger

<400>  14
agcaatggca ttgaagccag cctcctgact gatcccaagg atgtctccgg ccgcacggtc     60

gactacatca tcgctggtgg aggtctggtt ggactcacca ccgctgctcg tctgacggag    120

aaccccaaca tcagtgtgct cgtcatcgaa agtggctcct acgagtcgga cagaggtcct    180

atcattgagg acctgaacgc ctacggcgac atctttggca gcagtgtaga ccacgcctac    240

gagaccgtgg agctcgctac caacaatcaa accgcgctgg tccgctccgg aaatggtctc    300

ggtggctcta ctctagtgaa tggtggcacc tggactcgcc cccacaaggc acaggttgac    360

tcttgggaga ctgtctttgg aaatgagggc tggaactggg acaatgtggc cgcctactcc    420

ctccaggctg agcgtgctcg cgcaccaaat gccaaacaga tcgctgctgg ccactacttc    480

aacgcatcct gccatggtgt taatggtact gtccatgttg gaccccgcga caccggcgat    540

gactattctc ccatcgtcaa ggctctcatg agcgctgtcg aagaccgggg cgttcccacc    600

aagaaagact tcggatgcgg tgacccccat ggtgtgtcca tgttccccaa caccttgcac    660

gaagaccaag tgcgctccga tgccgctcgc gaatggctac ttcccaacta ccaacgtccc    720

aacctgcaag tcctgaccgg acagtatgtt ggtaaggtgc tccttagcca gaacggcacc    780

acccctcgtg ccgttggcgt ggaattcggc acccacaagg gcaacaccca caacgtttac    840

gctaagcacg aggtcctcct ggccgcgggc tccgctgtct ctcccacaat cctcgaatat    900

tccggtatcg gaatgaagtc catcctggag ccccttggta tcgacaccgt cgttgacctg    960

cccgtcggct tgaacctgca ggaccagacc accaataccg tccgctcccg catcacctct   1020

gctggtgcag gacagggaca ggccgcttgg ttcgccacct tcaacgagac ctttggtgac   1080

tattccgaaa aggcacacga gctgctcaac accaagctgg agcagtgggc cgaagaggcc   1140

gtcgcccgtg gcggattcca caacaccacc gccttgctca tccagtacga gaactaccgc   1200

gactggattg tcaaccacaa cgtcgcgtac tcggaactcg ttctcgacac tgccggagta   1260

gccagcttcg atgtgtggga ccttctgccc ttcacccgag gatacgttca catcctcgac   1320

aaggacccct accttcacca cttcgcctac gaccctcagt acttcctcaa cgagctggac   1380

ctgctcggtc aggctgccgc tactcaactg gcccgcaaca tctccaactc cggtgccatg   1440

cagacctact tcgctgggga gactatcccc ggtgataacc tcgcgtatga tgccgatttg   1500

agcgcctgga ctgagtacat cccgtaccac ttccgtccta actaccatgg cgtgggtact   1560

tgctccatga tgccgaagga gatgggcggt gttgttgata atgctgcccg tgtgtatggt   1620

gtgcagggac tgcgtgtcat tgatggttct attcctccta cgcaaatgtc gtcccatctg   1680

atgacggtgt tctatgccat ggcg                                          1704


<210>  15
<211>  1749
<212>  DNA
<213>  Aspergillus niger

<400>  15
agcaatggca ttgaagccag cctcctgact gatcccaagg atgtctccgg ccgcacggtc     60

gactacatca tcgctggtgg aggtctggtt ggactcacca ccgctgctcg tctgacggag    120

aaccccaaca tcagtgtgct cgtcatcgaa agtggctcct acgagtcgga cagaggtcct    180

atcattgagg acctgaacgc ctacggcgac atctttggca gcagtgtaga ccacgcctac    240

gagaccgtgg agctcgctac caacaatcaa accgcgctgg tccgctccgg aaatggtctc    300

ggtggctcta ctctagtgaa tggtggcacc tggactcgcc cccacaaggc acaggttgac    360

tcttgggaga ctgtctttgg aaatgagggc tggaactggg acaatgtggc cgcctactcc    420

ctccaggctg agcgtgctcg cgcaccaaat gccaaacaga tcgctgctgg ccactacttc    480

aacgcatcct gccatggtgt taatggtact gtccatgccg gaccccgcga caccggcgat    540

gactattctc ccatcgtcaa ggctctcatg agcgctgtcg aagaccgggg cgttcccacc    600

aagaaagact tcggatgcgg tgacccccat ggtgtgtcca tgttccccaa caccttgcac    660

gaagaccaag tgcgctccga tgccgctcgc gaatggctac ttcccaacta ccaacgtccc    720

aacctgcaag tcctgaccgg acagtatgtt ggtaaggtgc tccttagcca gaacggcacc    780

acccctcgtg ccgttggcgt ggaattcggc acccacaagg gcaacaccca caacgtttac    840

gctaagcacg aggtcctcct ggccgcgggc tccgctgtct ctcccacaat cctcgaatat    900

tccggtatcg gaatgaagtc catcctggag ccccttggta tcgacaccgt cgttgacctg    960

cccgtcggct tgaacctgca ggaccagacc accagtaccg tccgctcccg catcacctct   1020

gctggtgcag gacagggaca ggccgcttgg ttcgccacct tcaacgagac ctttggtgac   1080

tattccgaaa aggcacacga gctgctcaac accaagctgg agcagtgggc cgaagaggcc   1140

gtcgcccgtg gcggattcca caacaccacc gccttgctca tccagtacga gaactaccgc   1200

gactggattg tcaaccacaa cgtcgcgtac tcggaactct tcctcgacac tgccggagta   1260

gccagcttcg atgtgtggga ccttctgccc ttcacccgag gatacgttca catcctcgac   1320

aaggacccct accttcacca cttcgcctac gaccctcagt acttcctcaa cgagctggac   1380

ctgctcggtc aggctgccgc tactcaactg gcccgcaaca tctccaactc cggtgccatg   1440

cagacctact tcgctgggga gactatcccc ggtgataacc tcgcgtatga tgccgatttg   1500

agcgcctgga ctgagtacat cccgtaccac ttccgtccta actaccatgg cgtgggtact   1560

tgctccatga tgccgaagga gatgggcggt gttgttgata atgctgcccg tgtgtatggt   1620

gtgcagggac tgcgtgtcat tgatggttct attcctccta cgcaaatgtc gtcccatccg   1680

atgacggtgt tctatgccat ggcgctaaaa atttcggatg ctatcttgga agattatgct   1740

tccatgcag                                                           1749


<210>  16
<211>  1749
<212>  DNA
<213>  Aspergillus niger

<400>  16
agcaatggca ttgaagccag cctcctgact gatcccaagg atgtctccgg ccgcacggtc     60

gactacatca tcgctggtgg aggtctggtt ggactcacca ccgctgctcg tctgacggag    120

aaccccaaca tcagtgtgct cgtcatcgaa agtggcttct acgagtcgga cagaggtcct    180

atcattgagg acctgaacgc ctacggcgac atctttggca gcagtgtaga ccacgcctac    240

gagaccgtgg agctcgctac caacaatcaa accgcgctgg tccgctccgg aaatggtctc    300

ggtggctcta ctctagtgaa tggtggcacc tggactcgcc cccacaaggc acaggttgac    360

tcttgggaga ctgtctttgg aaatgagggc tggaactggg acaatgtggc cgcctactcc    420

ctccaggctg agcgtgctcg cgcaccaaat gccaaacaga tcgctgctgg ccactacttc    480

aacgcatcct gccatggtgt taatggtact gtccatgccg gaccccgcga caccggcgat    540

gactattctc ccatcgtcaa ggctctcatg agcgctgtcg aagaccgggg cgttcccacc    600

aagaaagact tcggatgcgg tgacccccat ggtgtgtcca tgttccccaa caccttgcac    660

gaagaccaag tgcgctccga tgccgctcgc gaatggctac ttcccaacta ccaacgtccc    720

aacctgcaag tcctgaccgg acagtatgtt ggtaaggtgc tccttagcca gaacggcacc    780

acccctcgtg ccgttggcgt ggaattcggc acccacaagg gcaacaccca caacgtttac    840

gctaagcacg aggtcctcct ggccgcgggc tccgctgtct ctcccacaat cctcgaatat    900

tccggtatcg gaatgaagtc catcctggag ccccttggta tcgacaccgt cgttgacctg    960

cccgtcggct tgaacctgca ggaccagacc accagtaccg tccgctcccg catcacctct   1020

gctggtgcag gacagggaca ggccgcttgg ttcgccacct tcaacgagac ctttggtgac   1080

tattccgaaa aggcacacga gctgctcaac accaagctgg agcagtgggc cgaagaggcc   1140

gtcgcccgtg gcggattcca caacaccacc gccttgctca tccagtacga gaactaccgc   1200

gactggattg tcaaccacaa cgtcgcgtac tcggaactct tcctcgacac tgccggagta   1260

gccagcttcg atgtgtggga ccttctgccc ttcacccgag gatacgttca catcctcgac   1320

aaggacccct accttcacca cttcgcctac gaccctcagt acttcctcaa cgagctggac   1380

ctgctcggtc aggctgccgc tactcaactg gcccgcaaca tctccaactc cggtgccatg   1440

cagacctact tcgctgggga gactatcccc ggtgataacc tcgcgtatga tgccgatttg   1500

agcgcctgga ctgagtacat cccgtaccac ttccgtccta actaccatgg cgtgggtact   1560

tgctccatga tgccgaagga gatgggcggt gttgttgata atgctgcccg tgtgtatggt   1620

gtgcagggac tgcgtgtcat tgatggttct attcctccta cgcaaatgtc gtcccatgtc   1680

atgacggtgt tctatgccat ggcgctaaaa atttcggatg ctatcttgga agattatgct   1740

tccatgcag                                                           1749


<210>  17
<211>  1749
<212>  DNA
<213>  Aspergillus niger

<400>  17
agcaatggca ttgaagccag cctcctgact gatcccaagg atgtctccgg ccgcacggtc     60

gactacatca tcgctggtgg aggtctggtt ggactcacca ccgctgctcg tctgacggag    120

aaccccaaca tcagtgtgct cgtcatcgaa agtggctcct acgagtcgga cagaggtcct    180

atcattgagg acctgaacgc ctacggcgac atctttggca gcagtgtaga ccacgcctac    240

gagaccgtgg agctcgctac caacaatcaa accgcgctgg tccgctccgg aaatggtctc    300

ggtggctcta ctctagtgaa tggtggcacc tggactcgcc cccacaaggc acaggttgac    360

tcttgggaga ctgtctttgg aaatgagggc tggaactggg acaatgtgtt ggcctactcc    420

ctccaggctg agcgtgctcg cgcaccaaat gccaaacaga tcgctgctgg ccactacttc    480

aacgcatcct gccatggtgt taatggtact gtccatgccg gaccccgcga caccggcgat    540

gactattctc ccatcgtcaa ggctctcatg agcgctgtcg aagaccgggg cgttcccacc    600

aagaaagact tcggatgcgg tgacccccat ggtgtgtcca tgttccccaa caccttgcac    660

gaagaccaag tgcgctccga tgccgctcgc gaatggctac ttcccaacta ccaacgtccc    720

aacctgcaag tcctgaccgg acagtatgtt ggtaaggtgc tccttagcca gaacggcacc    780

acccctcgtg ccgttggcgt ggaattcggc acccacaagg gcaacaccca caacgtttac    840

gctaagcacg aggtcctcct ggccgcgggc tccgctgtct ctcccacaat cctcgaatat    900

tccggtatcg gaatgaagtc catcctggag ccccttggta tcgacaccgt cgttgacctg    960

cccgtcggct tgaacctgca ggaccagacc accgctaccg tccgctcccg catcacctct   1020

gctggtgcag gacagggaca ggccgcttgg ttcgccacct tcaacgagac ctttggtgac   1080

tattccgaaa aggcacacga gctgctcaac accaagctgg agcagtgggc cgaagaggcc   1140

gtcgcccgtg gcggattcca caacaccacc gccttgctca tccagtacga gaactaccgc   1200

gactggattg tcaaccacaa cgtcgcgtac tcggaactct tcctcgacac tgccggagta   1260

gccagcttcg atgtgtggga ccttctgccc ttcacccgag gatacgttca catcctcgac   1320

aaggacccct accttcacca cttcgcctac gaccctcagt acttcctcaa cgagctggac   1380

ctgctcggtc aggctgccgc tactcaactg gcccgcaaca tctccaactc cggtgccatg   1440

cagacctact tcgctgggga gactatcccc ggtgataacc tcgcgtatga tgccgatttg   1500

agcgcctgga ctgagtacat cccgtaccac ttccgtccta actaccatgg cgtgggtact   1560

tgctccatga tgccgaagga gatgggcggt gttgttgata atgctgcccg tgtgtatggt   1620

gtgcagggac tgcgtgtcat tgatggttct attcctccta cgcaaatgtc gtcccatgtc   1680

atgacggtgt tctatgccat ggcgctaaaa atttcggatg ctatcttgga agattatgct   1740

tccatgcag                                                           1749


