                         SEQUENCE LISTING

<110>  Aarhus Universitet
       Region Midtjylland
       Mller, Holger
       Rdgaard-Hansen, Sidsel
 
<120>  Novel Disease-Marker

<130>  P3036PC00

<150>  DK PA 2013 70044
<151>  2013-01-25

<150>  DK PA 2013 70043
<151>  2013-01-25

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  1456
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Leu Pro Leu Leu Leu Val Phe Ala Ser Val Ile Pro Gly Ala 
1               5                   10                  15      


Val Leu Leu Leu Asp Thr Arg Gln Phe Leu Ile Tyr Asn Glu Asp His 
            20                  25                  30          


Lys Arg Cys Val Asp Ala Val Ser Pro Ser Ala Val Gln Thr Ala Ala 
        35                  40                  45              


Cys Asn Gln Asp Ala Glu Ser Gln Lys Phe Arg Trp Val Ser Glu Ser 
    50                  55                  60                  


Gln Ile Met Ser Val Ala Phe Lys Leu Cys Leu Gly Val Pro Ser Lys 
65                  70                  75                  80  


Thr Asp Trp Val Ala Ile Thr Leu Tyr Ala Cys Asp Ser Lys Ser Glu 
                85                  90                  95      


Phe Gln Lys Trp Glu Cys Lys Asn Asp Thr Leu Leu Gly Ile Lys Gly 
            100                 105                 110         


Glu Asp Leu Phe Phe Asn Tyr Gly Asn Arg Gln Glu Lys Asn Ile Met 
        115                 120                 125             


Leu Tyr Lys Gly Ser Gly Leu Trp Ser Arg Trp Lys Ile Tyr Gly Thr 
    130                 135                 140                 


Thr Asp Asn Leu Cys Ser Arg Gly Tyr Glu Ala Met Tyr Thr Leu Leu 
145                 150                 155                 160 


Gly Asn Ala Asn Gly Ala Thr Cys Ala Phe Pro Phe Lys Phe Glu Asn 
                165                 170                 175     


Lys Trp Tyr Ala Asp Cys Thr Ser Ala Gly Arg Ser Asp Gly Trp Leu 
            180                 185                 190         


Trp Cys Gly Thr Thr Thr Asp Tyr Asp Thr Asp Lys Leu Phe Gly Tyr 
        195                 200                 205             


Cys Pro Leu Lys Phe Glu Gly Ser Glu Ser Leu Trp Asn Lys Asp Pro 
    210                 215                 220                 


Leu Thr Ser Val Ser Tyr Gln Ile Asn Ser Lys Ser Ala Leu Thr Trp 
225                 230                 235                 240 


His Gln Ala Arg Lys Ser Cys Gln Gln Gln Asn Ala Glu Leu Leu Ser 
                245                 250                 255     


Ile Thr Glu Ile His Glu Gln Thr Tyr Leu Thr Gly Leu Thr Ser Ser 
            260                 265                 270         


Leu Thr Ser Gly Leu Trp Ile Gly Leu Asn Ser Leu Ser Phe Asn Ser 
        275                 280                 285             


Gly Trp Gln Trp Ser Asp Arg Ser Pro Phe Arg Tyr Leu Asn Trp Leu 
    290                 295                 300                 


Pro Gly Ser Pro Ser Ala Glu Pro Gly Lys Ser Cys Val Ser Leu Asn 
305                 310                 315                 320 


Pro Gly Lys Asn Ala Lys Trp Glu Asn Leu Glu Cys Val Gln Lys Leu 
                325                 330                 335     


Gly Tyr Ile Cys Lys Lys Gly Asn Thr Thr Leu Asn Ser Phe Val Ile 
            340                 345                 350         


Pro Ser Glu Ser Asp Val Pro Thr His Cys Pro Ser Gln Trp Trp Pro 
        355                 360                 365             


Tyr Ala Gly His Cys Tyr Lys Ile His Arg Asp Glu Lys Lys Ile Gln 
    370                 375                 380                 


Arg Asp Ala Leu Thr Thr Cys Arg Lys Glu Gly Gly Asp Leu Thr Ser 
385                 390                 395                 400 


Ile His Thr Ile Glu Glu Leu Asp Phe Ile Ile Ser Gln Leu Gly Tyr 
                405                 410                 415     


Glu Pro Asn Asp Glu Leu Trp Ile Gly Leu Asn Asp Ile Lys Ile Gln 
            420                 425                 430         


Met Tyr Phe Glu Trp Ser Asp Gly Thr Pro Val Thr Phe Thr Lys Trp 
        435                 440                 445             


Leu Arg Gly Glu Pro Ser His Glu Asn Asn Arg Gln Glu Asp Cys Val 
    450                 455                 460                 


Val Met Lys Gly Lys Asp Gly Tyr Trp Ala Asp Arg Gly Cys Glu Trp 
465                 470                 475                 480 


Pro Leu Gly Tyr Ile Cys Lys Met Lys Ser Arg Ser Gln Gly Pro Glu 
                485                 490                 495     


Ile Val Glu Val Glu Lys Gly Cys Arg Lys Gly Trp Lys Lys His His 
            500                 505                 510         


Phe Tyr Cys Tyr Met Ile Gly His Thr Leu Ser Thr Phe Ala Glu Ala 
        515                 520                 525             


Asn Gln Thr Cys Asn Asn Glu Asn Ala Tyr Leu Thr Thr Ile Glu Asp 
    530                 535                 540                 


Arg Tyr Glu Gln Ala Phe Leu Thr Ser Phe Val Gly Leu Arg Pro Glu 
545                 550                 555                 560 


Lys Tyr Phe Trp Thr Gly Leu Ser Asp Ile Gln Thr Lys Gly Thr Phe 
                565                 570                 575     


Gln Trp Thr Ile Glu Glu Glu Val Arg Phe Thr His Trp Asn Ser Asp 
            580                 585                 590         


Met Pro Gly Arg Lys Pro Gly Cys Val Ala Met Arg Thr Gly Ile Ala 
        595                 600                 605             


Gly Gly Leu Trp Asp Val Leu Lys Cys Asp Glu Lys Ala Lys Phe Val 
    610                 615                 620                 


Cys Lys His Trp Ala Glu Gly Val Thr His Pro Pro Lys Pro Thr Thr 
625                 630                 635                 640 


Thr Pro Glu Pro Lys Cys Pro Glu Asp Trp Gly Ala Ser Ser Arg Thr 
                645                 650                 655     


Ser Leu Cys Phe Lys Leu Tyr Ala Lys Gly Lys His Glu Lys Lys Thr 
            660                 665                 670         


Trp Phe Glu Ser Arg Asp Phe Cys Arg Ala Leu Gly Gly Asp Leu Ala 
        675                 680                 685             


Ser Ile Asn Asn Lys Glu Glu Gln Gln Thr Ile Trp Arg Leu Ile Thr 
    690                 695                 700                 


Ala Ser Gly Ser Tyr His Lys Leu Phe Trp Leu Gly Leu Thr Tyr Gly 
705                 710                 715                 720 


Ser Pro Ser Glu Gly Phe Thr Trp Ser Asp Gly Ser Pro Val Ser Tyr 
                725                 730                 735     


Glu Asn Trp Ala Tyr Gly Glu Pro Asn Asn Tyr Gln Asn Val Glu Tyr 
            740                 745                 750         


Cys Gly Glu Leu Lys Gly Asp Pro Thr Met Ser Trp Asn Asp Ile Asn 
        755                 760                 765             


Cys Glu His Leu Asn Asn Trp Ile Cys Gln Ile Gln Lys Gly Gln Thr 
    770                 775                 780                 


Pro Lys Pro Glu Pro Thr Pro Ala Pro Gln Asp Asn Pro Pro Val Thr 
785                 790                 795                 800 


Glu Asp Gly Trp Val Ile Tyr Lys Asp Tyr Gln Tyr Tyr Phe Ser Lys 
                805                 810                 815     


Glu Lys Glu Thr Met Asp Asn Ala Arg Ala Phe Cys Lys Arg Asn Phe 
            820                 825                 830         


Gly Asp Leu Val Ser Ile Gln Ser Glu Ser Glu Lys Lys Phe Leu Trp 
        835                 840                 845             


Lys Tyr Val Asn Arg Asn Asp Ala Gln Ser Ala Tyr Phe Ile Gly Leu 
    850                 855                 860                 


Leu Ile Ser Leu Asp Lys Lys Phe Ala Trp Met Asp Gly Ser Lys Val 
865                 870                 875                 880 


Asp Tyr Val Ser Trp Ala Thr Gly Glu Pro Asn Phe Ala Asn Glu Asp 
                885                 890                 895     


Glu Asn Cys Val Thr Met Tyr Ser Asn Ser Gly Phe Trp Asn Asp Ile 
            900                 905                 910         


Asn Cys Gly Tyr Pro Asn Ala Phe Ile Cys Gln Arg His Asn Ser Ser 
        915                 920                 925             


Ile Asn Ala Thr Thr Val Met Pro Thr Met Pro Ser Val Pro Ser Gly 
    930                 935                 940                 


Cys Lys Glu Gly Trp Asn Phe Tyr Ser Asn Lys Cys Phe Lys Ile Phe 
945                 950                 955                 960 


Gly Phe Met Glu Glu Glu Arg Lys Asn Trp Gln Glu Ala Arg Lys Ala 
                965                 970                 975     


Cys Ile Gly Phe Gly Gly Asn Leu Val Ser Ile Gln Asn Glu Lys Glu 
            980                 985                 990         


Gln Ala Phe Leu Thr Tyr His Met  Lys Asp Ser Thr Phe  Ser Ala Trp 
        995                 1000                 1005             


Thr Gly  Leu Asn Asp Val Asn  Ser Glu His Thr Phe  Leu Trp Thr 
    1010                 1015                 1020             


Asp Gly  Arg Gly Val His Tyr  Thr Asn Trp Gly Lys  Gly Tyr Pro 
    1025                 1030                 1035             


Gly Gly  Arg Arg Ser Ser Leu  Ser Tyr Glu Asp Ala  Asp Cys Val 
    1040                 1045                 1050             


Val Ile  Ile Gly Gly Ala Ser  Asn Glu Ala Gly Lys  Trp Met Asp 
    1055                 1060                 1065             


Asp Thr  Cys Asp Ser Lys Arg  Gly Tyr Ile Cys Gln  Thr Arg Ser 
    1070                 1075                 1080             


Asp Pro  Ser Leu Thr Asn Pro  Pro Ala Thr Ile Gln  Thr Asp Gly 
    1085                 1090                 1095             


Phe Val  Lys Tyr Gly Lys Ser  Ser Tyr Ser Leu Met  Arg Gln Lys 
    1100                 1105                 1110             


Phe Gln  Trp His Glu Ala Glu  Thr Tyr Cys Lys Leu  His Asn Ser 
    1115                 1120                 1125             


Leu Ile  Ala Ser Ile Leu Asp  Pro Tyr Ser Asn Ala  Phe Ala Trp 
    1130                 1135                 1140             


Leu Gln  Met Glu Thr Ser Asn  Glu Arg Val Trp Ile  Ala Leu Asn 
    1145                 1150                 1155             


Ser Asn  Leu Thr Asp Asn Gln  Tyr Thr Trp Thr Asp  Lys Trp Arg 
    1160                 1165                 1170             


Val Arg  Tyr Thr Asn Trp Ala  Ala Asp Glu Pro Lys  Leu Lys Ser 
    1175                 1180                 1185             


Ala Cys  Val Tyr Leu Asp Leu  Asp Gly Tyr Trp Lys  Thr Ala His 
    1190                 1195                 1200             


Cys Asn  Glu Ser Phe Tyr Phe  Leu Cys Lys Arg Ser  Asp Glu Ile 
    1205                 1210                 1215             


Pro Ala  Thr Glu Pro Pro Gln  Leu Pro Gly Arg Cys  Pro Glu Ser 
    1220                 1225                 1230             


Asp His  Thr Ala Trp Ile Pro  Phe His Gly His Cys  Tyr Tyr Ile 
    1235                 1240                 1245             


Glu Ser  Ser Tyr Thr Arg Asn  Trp Gly Gln Ala Ser  Leu Glu Cys 
    1250                 1255                 1260             


Leu Arg  Met Gly Ser Ser Leu  Val Ser Ile Glu Ser  Ala Ala Glu 
    1265                 1270                 1275             


Ser Ser  Phe Leu Ser Tyr Arg  Val Glu Pro Leu Lys  Ser Lys Thr 
    1280                 1285                 1290             


Asn Phe  Trp Ile Gly Leu Phe  Arg Asn Val Glu Gly  Thr Trp Leu 
    1295                 1300                 1305             


Trp Ile  Asn Asn Ser Pro Val  Ser Phe Val Asn Trp  Asn Thr Gly 
    1310                 1315                 1320             


Asp Pro  Ser Gly Glu Arg Asn  Asp Cys Val Ala Leu  His Ala Ser 
    1325                 1330                 1335             


Ser Gly  Phe Trp Ser Asn Ile  His Cys Ser Ser Tyr  Lys Gly Tyr 
    1340                 1345                 1350             


Ile Cys  Lys Arg Pro Lys Ile  Ile Asp Ala Lys Pro  Thr His Glu 
    1355                 1360                 1365             


Leu Leu  Thr Thr Lys Ala Asp  Thr Arg Lys Met Asp  Pro Ser Lys 
    1370                 1375                 1380             


Pro Ser  Ser Asn Val Ala Gly  Val Val Ile Ile Val  Ile Leu Leu 
    1385                 1390                 1395             


Ile Leu  Thr Gly Ala Gly Leu  Ala Ala Tyr Phe Phe  Tyr Lys Lys 
    1400                 1405                 1410             


Arg Arg  Val His Leu Pro Gln  Glu Gly Ala Phe Glu  Asn Thr Leu 
    1415                 1420                 1425             


Tyr Phe  Asn Ser Gln Ser Ser  Pro Gly Thr Ser Asp  Met Lys Asp 
    1430                 1435                 1440             


Leu Val  Gly Asn Ile Glu Gln  Asn Glu His Ser Val  Ile 
    1445                 1450                 1455     


<210>  2
<211>  1456
<212>  PRT
<213>  Mus musculus

<400>  2

Met Arg Leu Leu Leu Leu Leu Ala Phe Ile Ser Val Ile Pro Val Ser 
1               5                   10                  15      


Val Gln Leu Leu Asp Ala Arg Gln Phe Leu Ile Tyr Asn Glu Asp His 
            20                  25                  30          


Lys Arg Cys Val Asp Ala Leu Ser Ala Ile Ser Val Gln Thr Ala Thr 
        35                  40                  45              


Cys Asn Pro Glu Ala Glu Ser Gln Lys Phe Arg Trp Val Ser Asp Ser 
    50                  55                  60                  


Gln Ile Met Ser Val Ala Phe Lys Leu Cys Leu Gly Val Pro Ser Lys 
65                  70                  75                  80  


Thr Asp Trp Ala Ser Val Thr Leu Tyr Ala Cys Asp Ser Lys Ser Glu 
                85                  90                  95      


Tyr Gln Lys Trp Glu Cys Lys Asn Asp Thr Leu Phe Gly Ile Lys Gly 
            100                 105                 110         


Thr Glu Leu Tyr Phe Asn Tyr Gly Asn Arg Gln Glu Lys Asn Ile Lys 
        115                 120                 125             


Leu Tyr Lys Gly Ser Gly Leu Trp Ser Arg Trp Lys Val Tyr Gly Thr 
    130                 135                 140                 


Thr Asp Asp Leu Cys Ser Arg Gly Tyr Glu Ala Met Tyr Ser Leu Leu 
145                 150                 155                 160 


Gly Asn Ala Asn Gly Ala Val Cys Ala Phe Pro Phe Lys Phe Glu Asn 
                165                 170                 175     


Lys Trp Tyr Ala Asp Cys Thr Ser Ala Gly Arg Ser Asp Gly Trp Leu 
            180                 185                 190         


Trp Cys Gly Thr Thr Thr Asp Tyr Asp Lys Asp Lys Leu Phe Gly Phe 
        195                 200                 205             


Cys Pro Leu His Phe Glu Gly Ser Glu Arg Leu Trp Asn Lys Asp Pro 
    210                 215                 220                 


Leu Thr Gly Ile Leu Tyr Gln Ile Asn Ser Lys Ser Ala Leu Thr Trp 
225                 230                 235                 240 


His Gln Ala Arg Ala Ser Cys Lys Gln Gln Asn Ala Asp Leu Leu Ser 
                245                 250                 255     


Val Thr Glu Ile His Glu Gln Met Tyr Leu Thr Gly Leu Thr Ser Ser 
            260                 265                 270         


Leu Ser Ser Gly Leu Trp Ile Gly Leu Asn Ser Leu Ser Val Arg Ser 
        275                 280                 285             


Gly Trp Gln Trp Ala Gly Gly Ser Pro Phe Arg Tyr Leu Asn Trp Leu 
    290                 295                 300                 


Pro Gly Ser Pro Ser Ser Glu Pro Gly Lys Ser Cys Val Ser Leu Asn 
305                 310                 315                 320 


Pro Gly Lys Asn Ala Lys Trp Glu Asn Leu Glu Cys Val Gln Lys Leu 
                325                 330                 335     


Gly Tyr Ile Cys Lys Lys Gly Asn Asn Thr Leu Asn Pro Phe Ile Ile 
            340                 345                 350         


Pro Ser Ala Ser Asp Val Pro Thr Gly Cys Pro Asn Gln Trp Trp Pro 
        355                 360                 365             


Tyr Ala Gly His Cys Tyr Arg Ile His Arg Glu Glu Lys Lys Ile Gln 
    370                 375                 380                 


Lys Tyr Ala Leu Gln Ala Cys Arg Lys Glu Gly Gly Asp Leu Ala Ser 
385                 390                 395                 400 


Ile His Ser Ile Glu Glu Phe Asp Phe Ile Phe Ser Gln Leu Gly Tyr 
                405                 410                 415     


Glu Pro Asn Asp Glu Leu Trp Ile Gly Leu Asn Asp Ile Lys Ile Gln 
            420                 425                 430         


Met Tyr Phe Glu Trp Ser Asp Gly Thr Pro Val Thr Phe Thr Lys Trp 
        435                 440                 445             


Leu Pro Gly Glu Pro Ser His Glu Asn Asn Arg Gln Glu Asp Cys Val 
    450                 455                 460                 


Val Met Lys Gly Lys Asp Gly Tyr Trp Ala Asp Arg Ala Cys Glu Gln 
465                 470                 475                 480 


Pro Leu Gly Tyr Ile Cys Lys Met Val Ser Gln Ser His Ala Val Val 
                485                 490                 495     


Pro Glu Gly Ala Asp Lys Gly Cys Arg Lys Gly Trp Lys Arg His Gly 
            500                 505                 510         


Phe Tyr Cys Tyr Leu Ile Gly Ser Thr Leu Ser Thr Phe Thr Asp Ala 
        515                 520                 525             


Asn His Thr Cys Thr Asn Glu Lys Ala Tyr Leu Thr Thr Val Glu Asp 
    530                 535                 540                 


Arg Tyr Glu Gln Ala Phe Leu Thr Ser Leu Val Gly Leu Arg Pro Glu 
545                 550                 555                 560 


Lys Tyr Phe Trp Thr Gly Leu Ser Asp Val Gln Asn Lys Gly Thr Phe 
                565                 570                 575     


Arg Trp Thr Val Asp Glu Gln Val Gln Phe Thr His Trp Asn Ala Asp 
            580                 585                 590         


Met Pro Gly Arg Lys Ala Gly Cys Val Ala Met Lys Thr Gly Val Ala 
        595                 600                 605             


Gly Gly Leu Trp Asp Val Leu Ser Cys Glu Glu Lys Ala Lys Phe Val 
    610                 615                 620                 


Cys Lys His Trp Ala Glu Gly Val Thr Arg Pro Pro Glu Pro Thr Thr 
625                 630                 635                 640 


Thr Pro Glu Pro Lys Cys Pro Glu Asn Trp Gly Thr Thr Ser Lys Thr 
                645                 650                 655     


Ser Met Cys Phe Lys Leu Tyr Ala Lys Gly Lys His Glu Lys Lys Thr 
            660                 665                 670         


Trp Phe Glu Ser Arg Asp Phe Cys Lys Ala Ile Gly Gly Glu Leu Ala 
        675                 680                 685             


Ser Ile Lys Ser Lys Asp Glu Gln Gln Val Ile Trp Arg Leu Ile Thr 
    690                 695                 700                 


Ser Ser Gly Ser Tyr His Glu Leu Phe Trp Leu Gly Leu Thr Tyr Gly 
705                 710                 715                 720 


Ser Pro Ser Glu Gly Phe Thr Trp Ser Asp Gly Ser Pro Val Ser Tyr 
                725                 730                 735     


Glu Asn Trp Ala Tyr Gly Glu Pro Asn Asn Tyr Gln Asn Val Glu Tyr 
            740                 745                 750         


Cys Gly Glu Leu Lys Gly Asp Pro Gly Met Ser Trp Asn Asp Ile Asn 
        755                 760                 765             


Cys Glu His Leu Asn Asn Trp Ile Cys Gln Ile Gln Lys Gly Lys Thr 
    770                 775                 780                 


Leu Leu Pro Glu Pro Thr Pro Ala Pro Gln Asp Asn Pro Pro Val Thr 
785                 790                 795                 800 


Ala Asp Gly Trp Val Ile Tyr Lys Asp Tyr Gln Tyr Tyr Phe Ser Lys 
                805                 810                 815     


Glu Lys Glu Thr Met Asp Asn Ala Arg Ala Phe Cys Lys Lys Asn Phe 
            820                 825                 830         


Gly Asp Leu Ala Thr Ile Lys Ser Glu Ser Glu Lys Lys Phe Leu Trp 
        835                 840                 845             


Lys Tyr Ile Asn Lys Asn Gly Gly Gln Ser Pro Tyr Phe Ile Gly Met 
    850                 855                 860                 


Leu Ile Ser Met Asp Lys Lys Phe Ile Trp Met Asp Gly Ser Lys Val 
865                 870                 875                 880 


Asp Phe Val Ala Trp Ala Thr Gly Glu Pro Asn Phe Ala Asn Asp Asp 
                885                 890                 895     


Glu Asn Cys Val Thr Met Tyr Thr Asn Ser Gly Phe Trp Asn Asp Ile 
            900                 905                 910         


Asn Cys Gly Tyr Pro Asn Asn Phe Ile Cys Gln Arg His Asn Ser Ser 
        915                 920                 925             


Ile Asn Ala Thr Ala Met Pro Thr Thr Pro Thr Thr Pro Gly Gly Cys 
    930                 935                 940                 


Lys Glu Gly Trp His Leu Tyr Lys Asn Lys Cys Phe Lys Ile Phe Gly 
945                 950                 955                 960 


Phe Ala Asn Glu Glu Lys Lys Ser Trp Gln Asp Ala Arg Gln Ala Cys 
                965                 970                 975     


Lys Gly Leu Lys Gly Asn Leu Val Ser Ile Glu Asn Ala Gln Glu Gln 
            980                 985                 990         


Ala Phe Val Thr Tyr His Met Arg  Asp Ser Thr Phe Asn  Ala Trp Thr 
        995                 1000                 1005             


Gly Leu  Asn Asp Ile Asn Ala  Glu His Met Phe Leu  Trp Thr Ala 
    1010                 1015                 1020             


Gly Gln  Gly Val His Tyr Thr  Asn Trp Gly Lys Gly  Tyr Pro Gly 
    1025                 1030                 1035             


Gly Arg  Arg Ser Ser Leu Ser  Tyr Glu Asp Ala Asp  Cys Val Val 
    1040                 1045                 1050             


Val Ile  Gly Gly Asn Ser Arg  Glu Ala Gly Thr Trp  Met Asp Asp 
    1055                 1060                 1065             


Thr Cys  Asp Ser Lys Gln Gly  Tyr Ile Cys Gln Thr  Gln Thr Asp 
    1070                 1075                 1080             


Pro Ser  Leu Pro Val Ser Pro  Thr Thr Thr Pro Lys  Asp Gly Phe 
    1085                 1090                 1095             


Val Thr  Tyr Gly Lys Ser Ser  Tyr Ser Leu Met Lys  Leu Lys Leu 
    1100                 1105                 1110             


Pro Trp  His Glu Ala Glu Thr  Tyr Cys Lys Asp His  Thr Ser Leu 
    1115                 1120                 1125             


Leu Ala  Ser Ile Leu Asp Pro  Tyr Ser Asn Ala Phe  Ala Trp Met 
    1130                 1135                 1140             


Lys Met  His Pro Phe Asn Val  Pro Ile Trp Ile Ala  Leu Asn Ser 
    1145                 1150                 1155             


Asn Leu  Thr Asn Asn Glu Tyr  Thr Trp Thr Asp Arg  Trp Arg Val 
    1160                 1165                 1170             


Arg Tyr  Thr Asn Trp Gly Ala  Asp Glu Pro Lys Leu  Lys Ser Ala 
    1175                 1180                 1185             


Cys Val  Tyr Met Asp Val Asp  Gly Tyr Trp Arg Thr  Ser Tyr Cys 
    1190                 1195                 1200             


Asn Glu  Ser Phe Tyr Phe Leu  Cys Lys Lys Ser Asp  Glu Ile Pro 
    1205                 1210                 1215             


Ala Thr  Glu Pro Pro Gln Leu  Pro Gly Lys Cys Pro  Glu Ser Glu 
    1220                 1225                 1230             


Gln Thr  Ala Trp Ile Pro Phe  Tyr Gly His Cys Tyr  Tyr Phe Glu 
    1235                 1240                 1245             


Ser Ser  Phe Thr Arg Ser Trp  Gly Gln Ala Ser Leu  Glu Cys Leu 
    1250                 1255                 1260             


Arg Met  Gly Ala Ser Leu Val  Ser Ile Glu Thr Ala  Ala Glu Ser 
    1265                 1270                 1275             


Ser Phe  Leu Ser Tyr Arg Val  Glu Pro Leu Lys Ser  Lys Thr Asn 
    1280                 1285                 1290             


Phe Trp  Ile Gly Met Phe Arg  Asn Val Glu Gly Lys  Trp Leu Trp 
    1295                 1300                 1305             


Leu Asn  Asp Asn Pro Val Ser  Phe Val Asn Trp Lys  Thr Gly Asp 
    1310                 1315                 1320             


Pro Ser  Gly Glu Arg Asn Asp  Cys Val Val Leu Ala  Ser Ser Ser 
    1325                 1330                 1335             


Gly Leu  Trp Asn Asn Ile His  Cys Ser Ser Tyr Lys  Gly Phe Ile 
    1340                 1345                 1350             


Cys Lys  Met Pro Lys Ile Ile  Asp Pro Val Thr Thr  His Ser Ser 
    1355                 1360                 1365             


Ile Thr  Thr Lys Ala Asp Gln  Arg Lys Met Asp Pro  Gln Pro Lys 
    1370                 1375                 1380             


Gly Ser  Ser Lys Ala Ala Gly  Val Val Thr Val Val  Leu Leu Ile 
    1385                 1390                 1395             


Val Ile  Gly Ala Gly Val Ala  Ala Tyr Phe Phe Tyr  Lys Lys Arg 
    1400                 1405                 1410             


His Ala  Leu His Ile Pro Gln  Glu Ala Thr Phe Glu  Asn Thr Leu 
    1415                 1420                 1425             


Tyr Phe  Asn Ser Asn Leu Ser  Pro Gly Thr Ser Asp  Thr Lys Asp 
    1430                 1435                 1440             


Leu Met  Gly Asn Ile Glu Gln  Asn Glu His Ala Ile  Ile 
    1445                 1450                 1455     


<210>  3
<211>  1463
<212>  PRT
<213>  Rattus norvegicus

<400>  3

Met Glu His Thr Leu Trp Ala Met Arg Leu Pro Leu Leu Leu Ala Phe 
1               5                   10                  15      


Ile Ser Val Ile Pro Val Ala Val Gln Leu Leu Asp Ser Arg Gln Phe 
            20                  25                  30          


Leu Ile Tyr Asn Glu Asp His Lys Arg Cys Val Asp Ala Leu Ser Ala 
        35                  40                  45              


Ile Ser Val Gln Thr Ala Thr Cys Asn Pro Glu Ala Glu Ser Gln Lys 
    50                  55                  60                  


Phe Arg Trp Val Ser Glu Ser Gln Ile Met Ser Val Ala Phe Lys Leu 
65                  70                  75                  80  


Cys Leu Gly Val Pro Ser Lys Thr Asp Trp Ala Ser Val Thr Leu Tyr 
                85                  90                  95      


Ala Cys Asp Ser Lys Ser Glu Phe Gln Lys Trp Glu Cys Lys Asn Asp 
            100                 105                 110         


Thr Leu Phe Gly Ile Lys Gly Thr Glu Leu Tyr Phe Asn Tyr Gly Asn 
        115                 120                 125             


Arg Gln Glu Lys Asn Ile Lys Leu Tyr Lys Gly Ser Gly Leu Trp Ser 
    130                 135                 140                 


Arg Trp Lys Val Tyr Gly Thr Thr Asp Asp Leu Cys Ser Arg Gly Tyr 
145                 150                 155                 160 


Glu Ala Met Tyr Ser Leu Leu Gly Asn Ala Asn Gly Ala Val Cys Ala 
                165                 170                 175     


Phe Pro Phe Lys Phe Glu Asn Lys Trp Tyr Ala Asp Cys Thr Ser Ala 
            180                 185                 190         


Gly Arg Ser Asp Gly Trp Leu Trp Cys Gly Thr Thr Thr Asp Tyr Asp 
        195                 200                 205             


Thr Asp Lys Leu Phe Gly Phe Cys Pro Leu Gln Phe Glu Gly Ser Lys 
    210                 215                 220                 


Arg Leu Trp Asn Thr Asp Pro Leu Thr Gly Ile Leu Tyr Gln Ile Asn 
225                 230                 235                 240 


Ser Lys Ser Ala Leu Thr Trp His Gln Ala Arg Ala Ser Cys Lys Gln 
                245                 250                 255     


Gln Asn Ala Glu Leu Leu Ser Val Thr Glu Ile His Glu Gln Met Tyr 
            260                 265                 270         


Leu Thr Gly Leu Thr Ser Ser Leu Thr Ser Gly Leu Trp Ile Gly Leu 
        275                 280                 285             


Asn Ser Leu Ser Leu Ser Thr Gly Trp Gln Trp Ala Gly Gly Ser Pro 
    290                 295                 300                 


Phe Arg Tyr Leu Asn Trp Leu Pro Gly Ser Pro Ser Ser Glu Pro Gly 
305                 310                 315                 320 


Lys Ser Cys Val Ser Leu Asn Pro Gly Lys Asn Ala Lys Trp Glu Asn 
                325                 330                 335     


Leu Glu Cys Val Gln Lys Leu Gly Tyr Ile Cys Lys Lys Gly Asn Asn 
            340                 345                 350         


Thr Leu Asn Pro Phe Ile Ile Pro Ser Glu Ser Asp Val Pro Thr Ala 
        355                 360                 365             


Cys Pro Asn Gln Trp Trp Pro Tyr Ala Gly His Cys Tyr Arg Ile Tyr 
    370                 375                 380                 


Arg Glu Glu Lys Lys Ile Gln Lys Tyr Ala Leu Gln Ala Cys Arg Lys 
385                 390                 395                 400 


Glu Gly Gly Asp Leu Ala Ser Ile His Ser Ile Glu Glu Phe Asp Phe 
                405                 410                 415     


Ile Phe Ser Gln Leu Gly Tyr Glu Pro Asn Asp Glu Leu Trp Ile Gly 
            420                 425                 430         


Leu Asn Asp Ile Lys Ile Gln Met Tyr Phe Glu Trp Ser Asp Gly Thr 
        435                 440                 445             


Pro Val Thr Phe Thr Lys Trp Leu Pro Gly Glu Pro Ser His Glu Asn 
    450                 455                 460                 


Asn Arg Gln Glu Asp Cys Val Val Met Lys Gly Lys Asp Gly Tyr Trp 
465                 470                 475                 480 


Ala Asp Arg Ala Cys Glu Gln Pro Leu Gly Tyr Ile Cys Lys Met Val 
                485                 490                 495     


Ser Gln Ile His Thr Val Ile Pro Glu Gly Ala Glu Lys Gly Cys Arg 
            500                 505                 510         


Lys Gly Trp Lys Arg His Gly Phe Tyr Cys Tyr Leu Ile Gly Ser Thr 
        515                 520                 525             


Leu Ser Thr Phe Ala Asp Ala Asn Gln Thr Cys Thr Asn Glu Lys Ala 
    530                 535                 540                 


Tyr Leu Thr Thr Val Glu Asp Arg Tyr Glu Gln Ala Phe Leu Thr Ser 
545                 550                 555                 560 


Leu Val Gly Leu Arg Pro Glu Lys Tyr Phe Trp Thr Gly Leu Ser Asp 
                565                 570                 575     


Val Gln Asn Lys Gly Thr Phe Arg Trp Thr Val Asp Glu Gln Val Gln 
            580                 585                 590         


Phe Thr His Trp Asn Ala Asp Met Pro Gly Arg Lys Ala Gly Cys Val 
        595                 600                 605             


Ala Met Lys Thr Gly Val Ala Gly Gly Leu Trp Asp Val Leu Ser Cys 
    610                 615                 620                 


Glu Glu Lys Ala Lys Phe Val Cys Lys His Trp Ala Glu Gly Val Thr 
625                 630                 635                 640 


Arg Pro Pro Glu Pro Thr Thr Thr Pro Glu Pro Lys Cys Pro Glu Asp 
                645                 650                 655     


Trp Gly Thr Thr Ser Lys Thr Ser Met Cys Phe Lys Leu Tyr Ala Lys 
            660                 665                 670         


Gly Lys His Glu Lys Lys Thr Trp Phe Glu Ser Arg Asp Phe Cys Lys 
        675                 680                 685             


Ala Ile Gly Gly Glu Leu Ala Ser Ile Lys Ser Lys Asp Glu Gln Gln 
    690                 695                 700                 


Val Ile Trp Arg Leu Ile Thr Ser Ser Gly Ser Tyr His Glu Leu Phe 
705                 710                 715                 720 


Trp Leu Gly Leu Thr Tyr Gly Ser Pro Ser Glu Gly Phe Thr Trp Ser 
                725                 730                 735     


Asp Gly Ser Pro Val Ser Tyr Glu Asn Trp Ala Tyr Gly Glu Pro Asn 
            740                 745                 750         


Asn Tyr Gln Asn Val Glu Tyr Cys Gly Glu Leu Lys Gly Asp Pro Gly 
        755                 760                 765             


Met Ser Trp Asn Asp Ile Asn Cys Glu His Leu Asn Asn Trp Ile Cys 
    770                 775                 780                 


Gln Ile Gln Lys Gly Lys Thr Leu Leu Pro Glu Pro Thr Pro Ala Pro 
785                 790                 795                 800 


Gln Asp Asn Pro Pro Val Thr Ala Asp Gly Trp Val Ile Tyr Lys Asp 
                805                 810                 815     


Tyr Gln Tyr Tyr Phe Ser Lys Glu Lys Glu Thr Met Asp Asn Ala Arg 
            820                 825                 830         


Ala Phe Cys Lys Lys Asn Phe Gly Asp Leu Ala Thr Ile Lys Ser Glu 
        835                 840                 845             


Ser Glu Lys Lys Phe Leu Trp Lys Tyr Ile Asn Lys Asn Gly Gly Gln 
    850                 855                 860                 


Ser Pro Tyr Phe Ile Gly Leu Leu Ile Ser Leu Asp Lys Lys Phe Ile 
865                 870                 875                 880 


Trp Met Asp Gly Ser Lys Val Asp Phe Val Ala Trp Ala Thr Gly Glu 
                885                 890                 895     


Pro Asn Phe Ala Asn Asp Asp Glu Asn Cys Val Thr Met Tyr Thr Asn 
            900                 905                 910         


Ser Gly Phe Trp Asn Asp Ile Asn Cys Gly Tyr Pro Asn Asn Phe Ile 
        915                 920                 925             


Cys Gln Arg His Asn Ser Ser Ile Asn Ala Thr Ala Met Pro Thr Thr 
    930                 935                 940                 


Pro Pro Thr Pro Gly Gly Cys Lys Glu Gly Trp His Leu Tyr Asn Asn 
945                 950                 955                 960 


Lys Cys Phe Lys Ile Phe Gly Phe Ala Glu Glu Glu Lys Lys Thr Trp 
                965                 970                 975     


Lys Glu Ala Arg Lys Ala Cys Ile Gly Leu Lys Gly Asn Leu Val Ser 
            980                 985                 990         


Ile Glu Asn Ala Lys Glu Gln Ala  Phe Val Thr Tyr His  Met Arg Asp 
        995                 1000                 1005             


Ser Thr  Phe Asn Ala Trp Thr  Gly Leu Asn Asp Val  Asn Ser Glu 
    1010                 1015                 1020             


His Thr  Phe Leu Trp Thr Asp  Gly Arg Gly Val His  Tyr Thr Asn 
    1025                 1030                 1035             


Trp Gly  Lys Gly Tyr Pro Gly  Gly Arg Arg Ser Ser  Leu Ser Tyr 
    1040                 1045                 1050             


Glu Asp  Val Asp Cys Val Val  Val Ile Gly Gly Asn  Ser Arg Glu 
    1055                 1060                 1065             


Ala Gly  Thr Trp Met Asp Ser  Thr Cys Asp Ser Lys  Gln Gly Tyr 
    1070                 1075                 1080             


Ile Cys  Gln Thr Gln Thr Asp  Pro Ser Val Pro Ile  Ser Pro Thr 
    1085                 1090                 1095             


Thr Ala  Pro Lys Asp Gly Phe  Val Lys Tyr Gly Lys  Ser Ser Tyr 
    1100                 1105                 1110             


Ala Leu  Met Lys Leu Lys Ser  Pro Trp His Glu Ala  Glu Lys Tyr 
    1115                 1120                 1125             


Cys Lys  Asp Arg Thr Ser Leu  Leu Ala Ser Ile Leu  Asp Pro Tyr 
    1130                 1135                 1140             


Ser Asn  Ala Phe Ala Trp Met  Lys Met His Pro Phe  Asn Val Pro 
    1145                 1150                 1155             


Ile Trp  Ile Ala Leu Asn Ser  Asn Leu Thr Asn Asn  Glu Tyr Thr 
    1160                 1165                 1170             


Trp Thr  Asp Lys Trp Arg Val  Arg Tyr Thr Asn Trp  Gly Thr Asp 
    1175                 1180                 1185             


Glu Pro  Lys Leu Lys Ser Ala  Cys Val Tyr Met Asp  Val Asp Gly 
    1190                 1195                 1200             


Tyr Trp  Lys Thr Ser Tyr Cys  Asn Glu Ser Phe Tyr  Phe Leu Cys 
    1205                 1210                 1215             


Lys Lys  Ser Asp Glu Ile Pro  Ala Thr Glu Pro Pro  Gln Leu Pro 
    1220                 1225                 1230             


Gly Lys  Cys Pro Glu Ser Glu  Gln Thr Ala Trp Ile  Pro Phe His 
    1235                 1240                 1245             


Gly His  Cys Tyr Tyr Ile Glu  Ser Ser Phe Thr Arg  Ser Trp Gly 
    1250                 1255                 1260             


Gln Ala  Ser Leu Glu Cys Leu  Arg Met Gly Ala Ser  Leu Val Ser 
    1265                 1270                 1275             


Ile Glu  Thr Ala Ala Glu Ser  Ser Phe Leu Ser Tyr  Arg Val Glu 
    1280                 1285                 1290             


Pro Leu  Lys Ser Lys Thr Asn  Phe Trp Ile Gly Met  Phe Arg Asn 
    1295                 1300                 1305             


Val Glu  Gly Lys Trp Leu Trp  Leu Asn Asp Asn Pro  Val Ser Phe 
    1310                 1315                 1320             


Val Asn  Trp Lys Thr Gly Asp  Pro Ser Gly Glu Arg  Asn Asp Cys 
    1325                 1330                 1335             


Val Val  Leu Ser Ser Ser Ser  Gly Leu Trp Asn Asn  Ile His Cys 
    1340                 1345                 1350             


Thr Ser  Tyr Lys Gly Phe Ile  Cys Lys Met Pro Lys  Ile Ile Asp 
    1355                 1360                 1365             


Pro Val  Thr Thr His Ser Ser  Ile Thr Thr Lys Ala  Asp Gln Arg 
    1370                 1375                 1380             


Lys Met  Asp Pro Gln Pro Lys  Gly Ser Ser Lys Ala  Ala Gly Val 
    1385                 1390                 1395             


Val Ile  Val Val Leu Leu Ile  Val Ile Gly Ala Gly  Val Ala Ala 
    1400                 1405                 1410             


Tyr Phe  Phe Tyr Lys Lys Arg  Arg Val Leu His Ile  Pro Gln Glu 
    1415                 1420                 1425             


Ala Thr  Phe Glu Asn Thr Leu  Tyr Phe Asn Ser Asn  Pro Ser Pro 
    1430                 1435                 1440             


Gly Thr  Ser Asp Thr Lys Asp  Leu Val Gly Asn Ile  Glu Gln Asn 
    1445                 1450                 1455             


Glu His  Ala Val Ile 
    1460             


<210>  4
<211>  1455
<212>  PRT
<213>  Sus scrofa

<400>  4

Met Arg Leu Ser Pro Cys Leu Ala Phe Leu Ser Phe Leu Pro Val Ala 
1               5                   10                  15      


Leu Gln Leu Leu Asp Thr Arg Gln Phe Leu Ile Tyr Asn Glu Asp His 
            20                  25                  30          


Lys Arg Cys Val Glu Ala Leu Ser Pro Ser Ser Val Gln Thr Ala Val 
        35                  40                  45              


Cys Asn Gln Asp Asn Glu Ala Gln Lys Phe Arg Trp Val Ser Glu Ser 
    50                  55                  60                  


Gln Ile Met Ser Val Ala Phe Lys Leu Cys Leu Gly Val Pro Ser Lys 
65                  70                  75                  80  


Thr Asp Trp Val Pro Val Thr Leu Tyr Ala Cys Asp Ser Lys Ser Glu 
                85                  90                  95      


Phe Gln Lys Trp Glu Cys Arg Asn Asp Thr Leu Leu Gly Ile Lys Gly 
            100                 105                 110         


Glu Asp Ile Phe Phe Asn Tyr Gly Asn Arg Gln Glu Lys Asn Ile Met 
        115                 120                 125             


Leu Tyr Lys Gly Ser Gly Leu Trp Ser Arg Trp Lys Val Tyr Gly Thr 
    130                 135                 140                 


Thr Asp Asp Leu Cys Ser Arg Gly Tyr Glu Ala Met Tyr Thr Leu Leu 
145                 150                 155                 160 


Gly Asn Ser Asn Gly Ala Thr Cys Ala Phe Pro Phe Lys Phe Glu Asn 
                165                 170                 175     


Lys Trp Tyr Ala Asp Cys Thr Thr Ala Gly Arg Ser Asp Gly Trp Leu 
            180                 185                 190         


Trp Cys Gly Thr Thr Thr Asp Tyr Asp Thr Asp Lys Leu Phe Gly Tyr 
        195                 200                 205             


Cys Pro Leu Lys Phe Glu Gly Ile Glu Arg Leu Trp Asn Lys Asp Pro 
    210                 215                 220                 


Leu Thr Ser Ile Ser Tyr Gln Ile Asn Ser Lys Ser Ala Leu Thr Trp 
225                 230                 235                 240 


His Gln Ala Arg Lys Ser Cys Gln Gln Gln Asn Ala Glu Leu Leu Ser 
                245                 250                 255     


Ile Thr Glu Ile His Glu Gln Thr Tyr Leu Thr Gly Leu Thr Ser Ser 
            260                 265                 270         


Leu Thr Ser Gly Leu Trp Ile Gly Leu Asn Ser Leu Ser Phe Asn Ser 
        275                 280                 285             


Gly Trp Gln Trp Ser Gly Gly Ser Pro Phe Arg Tyr Leu Asn Trp Leu 
    290                 295                 300                 


Pro Gly Ser Pro Ser Ala Glu Pro Gly Lys Ser Cys Val Ser Leu Asn 
305                 310                 315                 320 


Pro Gly Lys Asn Ala Lys Trp Glu Asn Leu Gln Cys Val Gln Lys Leu 
                325                 330                 335     


Gly Tyr Ile Cys Lys Lys Gly Asn Thr Thr Leu Asn Ser Phe Val Ile 
            340                 345                 350         


Pro Ser Glu Ser Asp Val Pro Thr Ser Cys Pro Ser Gln Trp Trp Pro 
        355                 360                 365             


Tyr Ala Gly His Cys Tyr Lys Ile Tyr Arg Glu Glu Lys Lys Ile Gln 
    370                 375                 380                 


Arg Asp Ala Leu Thr Ala Cys Arg Lys Glu Gly Gly Asp Leu Ala Ser 
385                 390                 395                 400 


Ile His Ser Ile Glu Glu Phe Asp Phe Ile Ile Ser Gln Leu Gly Tyr 
                405                 410                 415     


Glu Pro Asn Asp Glu Leu Trp Ile Gly Leu Asn Asp Ile Lys Ile Gln 
            420                 425                 430         


Met Tyr Phe Glu Trp Ser Asp Gly Thr Pro Val Thr Phe Thr Lys Trp 
        435                 440                 445             


Leu Pro Gly Glu Pro Ser His Glu Asn Asn Arg Gln Glu Asp Cys Ala 
    450                 455                 460                 


Val Met Lys Gly Lys Asp Gly Tyr Trp Ala Asp Arg Ala Cys Glu Arg 
465                 470                 475                 480 


Pro Leu Gly Tyr Ile Cys Lys Met Lys Ser Gln Ala Gln Thr Pro Gly 
                485                 490                 495     


Arg Val Glu Val Glu Thr Gly Cys Arg Lys Gly Trp Lys Arg His Gly 
            500                 505                 510         


Phe Tyr Cys Tyr Leu Ile Gly His Thr Leu Ser Thr Phe Ala Glu Ala 
        515                 520                 525             


Asn Gln Thr Cys Glu Asn Glu Lys Ala Tyr Leu Thr Thr Val Glu Asp 
    530                 535                 540                 


Arg Tyr Glu Gln Ala Phe Leu Thr Ser Leu Val Gly Leu Arg Pro Glu 
545                 550                 555                 560 


Arg Tyr Phe Trp Thr Gly Leu Ser Asp Val Gln Asn Lys Gly Thr Phe 
                565                 570                 575     


Gln Trp Thr Ile Ala Glu Gly Val Gln Phe Thr His Trp Asn Thr Asp 
            580                 585                 590         


Met Pro Gly Arg Lys Ala Gly Cys Val Ala Met Arg Thr Gly Val Ala 
        595                 600                 605             


Gly Gly Leu Trp Asp Val Leu Arg Cys Glu Glu Lys Asn Lys Phe Val 
    610                 615                 620                 


Cys Lys His Trp Ala Glu Gly Val Thr Arg Pro Pro Glu Pro Thr Thr 
625                 630                 635                 640 


Thr Pro Glu Pro Lys Cys Pro Glu Asp Trp Gly Thr Ser Thr Lys Thr 
                645                 650                 655     


Ser Leu Cys Phe Lys Leu Phe Ala Lys Gly Lys His Glu Lys Lys Thr 
            660                 665                 670         


Trp Phe Glu Ser Arg Asp Phe Cys Arg Ala Leu Gly Gly Asp Leu Ala 
        675                 680                 685             


Ser Ile Asn Asn Lys Glu Glu Gln Gln Ala Ile Trp Arg Leu Val Thr 
    690                 695                 700                 


Ala Ser Gly Ser Tyr His Glu Leu Phe Trp Leu Gly Leu Thr Tyr Ser 
705                 710                 715                 720 


Ser Pro Ser Glu Gly Phe Thr Trp Ser Asp Gly Ser Pro Val Ser Tyr 
                725                 730                 735     


Glu Asn Trp Ala Tyr Gly Glu Pro Asn Asn Tyr Gln Asn Val Glu Tyr 
            740                 745                 750         


Cys Gly Glu Leu Lys Ser Asp Ala Gly Met Ser Trp Asn Asp Ile Asn 
        755                 760                 765             


Cys Glu His Leu Asn Asn Trp Ile Cys Gln Ile Arg Lys Gly Gln Thr 
    770                 775                 780                 


Pro Lys Pro Glu Pro Thr Pro Ala Pro Gln Asp Asn Pro Pro Val Thr 
785                 790                 795                 800 


Glu Asp Gly Trp Val Ile Tyr Lys Asp Tyr Gln Tyr Tyr Phe Ser Lys 
                805                 810                 815     


Glu Lys Glu Thr Met Asp Lys Ala Arg Glu Phe Cys Lys Lys Asn Phe 
            820                 825                 830         


Gly Asp Leu Val Ser Ile Gln Ser Glu Ser Glu Lys Lys Phe Leu Trp 
        835                 840                 845             


Lys Tyr Val Asn Lys Asn Asp Ala Gln Pro Ala Tyr Phe Ile Gly Leu 
    850                 855                 860                 


Leu Ile Ser Leu Asp Lys Lys Phe Ile Trp Met Asp Gly Ser Lys Val 
865                 870                 875                 880 


Asp Tyr Val Ala Trp Ala Ala Gly Glu Pro Asn Phe Ala Asn Asp Asp 
                885                 890                 895     


Glu Asn Cys Val Thr Met Tyr Thr His Ser Gly Phe Trp Asn Asp Ile 
            900                 905                 910         


Asn Cys Gly Tyr Pro Asn Ala Phe Ile Cys Gln Arg His Asn Ser Ser 
        915                 920                 925             


Ile Asn Ala Thr Val Thr Pro Thr Ile Pro Ser Ala Pro Gly Gly Cys 
    930                 935                 940                 


Lys Glu Gly Trp Asn Phe Tyr Asn Asp Lys Cys Phe Lys Ile Phe Gly 
945                 950                 955                 960 


Phe Val Glu Glu Glu Arg Lys Asn Trp Gln Glu Ala Arg Lys Ala Cys 
                965                 970                 975     


Ile Gly Phe Gly Gly Asn Leu Ala Ser Ile Arg Asn Glu Lys Glu Gln 
            980                 985                 990         


Ala Phe Leu Thr Tyr His Met Lys  Asp Ser Thr Phe Asn  Ala Trp Thr 
        995                 1000                 1005             


Gly Leu  Asn Asp Val Asn Ser  Glu His Thr Phe Leu  Trp Thr Asp 
    1010                 1015                 1020             


Gly Arg  Gly Val His Tyr Thr  Asn Trp Gly Lys Gly  Tyr Pro Gly 
    1025                 1030                 1035             


Gly Arg  Arg Ser Ser Leu Ser  Tyr Glu Asp Ala Asp  Cys Val Val 
    1040                 1045                 1050             


Ile Ile  Gly Gly Lys Ser Arg  Asp Ala Gly Lys Trp  Met Asp Asp 
    1055                 1060                 1065             


Ile Cys  Asp Asn Lys Arg Gly  Tyr Ile Cys Gln Thr  Leu Pro Asp 
    1070                 1075                 1080             


Ser Ser  Leu Pro Arg Ser Pro  Thr Thr Ile Pro Thr  Asp Gly Phe 
    1085                 1090                 1095             


Ile Lys  Tyr Gly Glu Ser Ser  Tyr Ser Leu Thr Lys  Leu Lys Leu 
    1100                 1105                 1110             


Gln Trp  His Glu Ala Ala Asp  Tyr Cys Lys Leu His  Ser Ser Leu 
    1115                 1120                 1125             


Ile Ala  Ser Ile Leu Asp Pro  Tyr Ser Asn Ala Phe  Ala Trp Met 
    1130                 1135                 1140             


Gln Met  Gln Ala Leu Ser Glu  Pro Val Trp Ile Ala  Leu Asn Ser 
    1145                 1150                 1155             


Asn Leu  Thr Asn Asn Glu Tyr  Val Trp Thr Asp Lys  Trp Arg Val 
    1160                 1165                 1170             


Arg Tyr  Thr Asn Trp Ala Ala  Asp Glu Pro Arg Leu  Lys Thr Ala 
    1175                 1180                 1185             


Cys Val  Tyr Met Asp Leu Asp  Gly Ser Trp Lys Thr  Ala Asn Cys 
    1190                 1195                 1200             


Asn Glu  Ser Phe Tyr Phe Phe  Cys Lys Lys Ser Asp  Glu Thr Pro 
    1205                 1210                 1215             


Ala Thr  Glu Pro Pro Gln Leu  Pro Gly Arg Cys Pro  Glu Ser Glu 
    1220                 1225                 1230             


His Thr  Ala Trp Ile Pro Phe  His Gly His Cys Tyr  Tyr Ile Glu 
    1235                 1240                 1245             


Ser Ser  Tyr Thr Arg Asn Trp  Gly Gln Ala Ser Leu  Glu Cys Leu 
    1250                 1255                 1260             


Arg Met  Gly Ser Ser Leu Val  Ser Ile Glu Ser Ala  Ala Glu Ser 
    1265                 1270                 1275             


Ser Phe  Leu Ser Tyr Arg Val  Glu Pro Leu Gln Ser  Lys Thr Asn 
    1280                 1285                 1290             


Phe Trp  Ile Gly Leu Tyr Arg  Asn Val Glu Gly Met  Trp Leu Trp 
    1295                 1300                 1305             


Val Asn  Asn Asn Pro Val Ser  Phe Val Asn Trp Asn  Thr Gly Asp 
    1310                 1315                 1320             


Pro Ser  Gly Glu Arg Asn Asp  Cys Val Ala Leu Tyr  Ala Ser Ser 
    1325                 1330                 1335             


Gly Phe  Trp Asn Asn Ile His  Cys Ser Ser Tyr Lys  Gly Tyr Ile 
    1340                 1345                 1350             


Cys Lys  Arg Pro Lys Ile Val  Asp Ala Glu Pro Thr  His Ala Leu 
    1355                 1360                 1365             


Val Thr  Thr Lys Ala Asp Pro  Arg Lys Met Val Thr  Ser Lys Pro 
    1370                 1375                 1380             


Ser Ser  Asn Ser Ala Gly Val  Val Val Ile Val Val  Leu Leu Ile 
    1385                 1390                 1395             


Leu Thr  Gly Ala Gly Phe Ala  Ala Tyr Phe Phe Tyr  Lys Lys Arg 
    1400                 1405                 1410             


Arg Val  His Leu Pro Gln Glu  Glu Asn Phe Glu Asn  Thr Leu Tyr 
    1415                 1420                 1425             


Phe Asn  Ser Ala Ser Thr Pro  Gly Ala Ser Asp Thr  Lys Asp Leu 
    1430                 1435                 1440             


Ile Gly  Asn Ile Glu Gln Asn  Glu His Val Val Ile  
    1445                 1450                 1455 


<210>  5
<211>  1456
<212>  PRT
<213>  Macaca mulatta

<400>  5

Met Arg Leu Pro Leu Leu Leu Val Phe Ala Ser Val Ile Pro Gly Ala 
1               5                   10                  15      


Val Leu Leu Leu Asp Thr Arg Gln Phe Leu Ile Tyr Asn Glu Asp His 
            20                  25                  30          


Lys Arg Cys Val Glu Ala Val Ser Pro Ser Ala Val Gln Thr Ala Ala 
        35                  40                  45              


Cys Asn Gln Asp Ala Glu Ser Gln Lys Phe Arg Trp Val Ser Glu Ser 
    50                  55                  60                  


Gln Ile Met Ser Val Ala Phe Lys Leu Cys Leu Gly Val Pro Ser Lys 
65                  70                  75                  80  


Thr Asp Trp Val Ala Ile Thr Leu Tyr Ala Cys Asp Ser Lys Ser Glu 
                85                  90                  95      


Phe Gln Lys Trp Glu Cys Lys Asn Asp Thr Leu Leu Gly Ile Lys Gly 
            100                 105                 110         


Glu Asp Leu Phe Phe Asn Tyr Gly Asn Arg Gln Glu Lys Asn Val Met 
        115                 120                 125             


Leu Tyr Lys Gly Ser Gly Leu Trp Ser Arg Trp Lys Ile Tyr Gly Thr 
    130                 135                 140                 


Thr Asp Asn Leu Cys Ser Arg Gly Tyr Glu Ala Met Tyr Thr Leu Leu 
145                 150                 155                 160 


Gly Asn Ala Asn Gly Ala Thr Cys Ala Phe Pro Phe Lys Phe Glu Asn 
                165                 170                 175     


Lys Trp Tyr Ala Asp Cys Thr Ser Ala Gly Arg Ser Asp Gly Trp Leu 
            180                 185                 190         


Trp Cys Gly Thr Thr Thr Asp Tyr Asp Thr Asp Lys Leu Phe Gly Tyr 
        195                 200                 205             


Cys Pro Leu Lys Phe Glu Gly Ser Glu Ser Leu Trp Asn Lys Asp Pro 
    210                 215                 220                 


Leu Thr Ser Ile Ser Tyr Gln Ile Asn Ser Lys Ser Ala Leu Met Trp 
225                 230                 235                 240 


His Gln Ala Arg Lys Ser Cys Gln Gln Gln Asn Ala Glu Leu Leu Ser 
                245                 250                 255     


Ile Thr Glu Ile His Glu Gln Thr Tyr Leu Thr Gly Leu Thr Ser Ser 
            260                 265                 270         


Leu Thr Ser Gly Leu Trp Ile Gly Leu Asn Ser Leu Ser Phe Asn Ser 
        275                 280                 285             


Gly Trp Gln Trp Ser Asp Arg Ser Pro Phe Arg Tyr Leu Asn Trp Leu 
    290                 295                 300                 


Pro Gly Ser Pro Ser Ala Glu Pro Gly Lys Ser Cys Val Ser Leu Asn 
305                 310                 315                 320 


Pro Gly Lys Asn Ala Lys Trp Glu Asn Leu Glu Cys Val Gln Lys Leu 
                325                 330                 335     


Gly Tyr Ile Cys Lys Lys Gly Asn Thr Thr Leu Asn Ser Phe Val Ile 
            340                 345                 350         


Pro Ser Glu Ser Asp Val Pro Thr His Cys Pro Ser Gln Trp Trp Pro 
        355                 360                 365             


Tyr Ala Gly His Cys Tyr Lys Ile His Lys Asp Glu Lys Lys Ile Gln 
    370                 375                 380                 


Arg Asp Ala Leu Thr Ala Cys Arg Lys Glu Gly Gly Asp Leu Ala Ser 
385                 390                 395                 400 


Ile His Thr Ile Glu Glu Phe Asp Phe Ile Ile Ser Gln Leu Gly Tyr 
                405                 410                 415     


Glu Pro Asn Asp Glu Leu Trp Ile Gly Leu Asn Asp Ile Lys Ile Gln 
            420                 425                 430         


Met Tyr Phe Glu Trp Ser Asp Gly Thr Pro Val Thr Phe Thr Lys Trp 
        435                 440                 445             


Leu Arg Gly Glu Pro Ser His Glu Asn Asn Arg Gln Glu Asp Cys Val 
    450                 455                 460                 


Val Met Lys Gly Lys Asp Gly Tyr Trp Ala Asp Arg Gly Cys Glu Trp 
465                 470                 475                 480 


Pro Leu Gly Tyr Ile Cys Lys Met Lys Ser Arg Ser Gln Gly Pro Glu 
                485                 490                 495     


Ile Val Glu Val Glu Glu Gly Cys Lys Lys Gly Trp Lys Lys His His 
            500                 505                 510         


Phe Tyr Cys Tyr Met Ile Gly His Met Leu Ser Thr Phe Ala Glu Ala 
        515                 520                 525             


Asn Gln Thr Cys Asn Asn Glu Asn Ala Tyr Leu Thr Thr Ile Glu Asp 
    530                 535                 540                 


Arg Tyr Glu Gln Ala Phe Leu Thr Ser Phe Ile Gly Leu Arg Pro Glu 
545                 550                 555                 560 


Lys Tyr Phe Trp Thr Gly Leu Ser Asp Ile Gln Thr Lys Gly Thr Phe 
                565                 570                 575     


Gln Trp Thr Ile Glu Glu Glu Val Arg Phe Thr His Trp Asn Ser Asp 
            580                 585                 590         


Met Pro Gly Arg Lys Pro Gly Cys Val Ala Met Arg Thr Gly Ile Ala 
        595                 600                 605             


Gly Gly Leu Trp Asp Val Leu Lys Cys Asp Glu Lys Ala Lys Phe Val 
    610                 615                 620                 


Cys Lys His Trp Ala Glu Gly Val Thr His Pro Pro Lys Pro Thr Thr 
625                 630                 635                 640 


Thr Pro Glu Pro Lys Cys Pro Glu Asp Trp Gly Ala Ser Ser Arg Thr 
                645                 650                 655     


Ser Leu Cys Phe Lys Leu Tyr Ala Lys Gly Lys His Glu Lys Lys Thr 
            660                 665                 670         


Trp Phe Glu Ser Arg Asp Phe Cys Arg Ala Leu Gly Gly Asp Leu Ala 
        675                 680                 685             


Ser Ile Asn Asn Lys Glu Glu Gln Gln Thr Ile Trp Arg Leu Ile Thr 
    690                 695                 700                 


Ala Ser Gly Ser Tyr His Glu Leu Phe Trp Leu Gly Leu Thr Tyr Gly 
705                 710                 715                 720 


Ser Pro Ser Glu Gly Phe Thr Trp Ser Asp Gly Ser Pro Val Ser Tyr 
                725                 730                 735     


Glu Asn Trp Ala Tyr Gly Glu Pro Asn Asn Tyr Gln Asn Val Glu Tyr 
            740                 745                 750         


Cys Gly Glu Leu Lys Gly Asp Pro Ser Met Ser Trp Asn Asp Ile Asn 
        755                 760                 765             


Cys Glu His Leu Asn Asn Trp Ile Cys Gln Ile His Lys Gly Gln Thr 
    770                 775                 780                 


Pro Lys Pro Glu Pro Thr Pro Ala Pro Gln Asp Asn Pro Pro Val Thr 
785                 790                 795                 800 


Glu Asp Gly Trp Val Ile Tyr Lys Asp Tyr Gln Tyr Tyr Phe Ser Lys 
                805                 810                 815     


Glu Lys Glu Thr Met Asp Asn Ala Arg Ala Phe Cys Lys Arg Asn Phe 
            820                 825                 830         


Gly Asp Leu Val Ser Ile Gln Ser Glu Ser Glu Lys Lys Phe Leu Trp 
        835                 840                 845             


Lys Tyr Val Asn Arg Asn Asp Ala Gln Ser Ala Tyr Phe Ile Gly Leu 
    850                 855                 860                 


Leu Ile Ser Leu Asp Lys Lys Phe Ala Trp Met Asp Gly Ser Lys Val 
865                 870                 875                 880 


Asp Tyr Val Ser Trp Ala Thr Gly Glu Pro Asn Phe Ala Asn Glu Asp 
                885                 890                 895     


Glu Asn Cys Val Thr Met Tyr Ser Asn Ser Gly Phe Trp Asn Asp Ile 
            900                 905                 910         


Asn Cys Gly Tyr Pro Asn Ala Phe Ile Cys Gln Arg His Asn Ser Ser 
        915                 920                 925             


Ile Asn Ala Thr Thr Val Met Pro Thr Lys Pro Ser Val Pro Ser Gly 
    930                 935                 940                 


Cys Lys Glu Gly Trp Asn Phe Tyr Asn Asn Lys Cys Phe Lys Ile Phe 
945                 950                 955                 960 


Gly Phe Val Glu Glu Glu Arg Lys Thr Trp Gln Glu Ala Arg Lys Ala 
                965                 970                 975     


Cys Ile Gly Phe Gly Gly Asn Leu Val Ser Ile Gln Asn Glu Lys Glu 
            980                 985                 990         


Gln Ala Phe Leu Thr Tyr His Met  Lys Asp Ser Thr Phe  Ser Ala Trp 
        995                 1000                 1005             


Thr Gly  Leu Asn Asp Val Asn  Ser Glu His Thr Phe  Leu Trp Thr 
    1010                 1015                 1020             


Asp Gly  Arg Gly Val His Tyr  Thr Asn Trp Gly Lys  Gly Tyr Pro 
    1025                 1030                 1035             


Gly Gly  Arg Arg Ser Ser Leu  Ser Tyr Glu Asp Ala  Asp Cys Val 
    1040                 1045                 1050             


Val Ile  Ile Gly Gly Ala Ser  Asn Glu Ala Gly Lys  Trp Met Asp 
    1055                 1060                 1065             


Asp Thr  Cys Asp Gly Lys Arg  Gly Tyr Ile Cys Gln  Thr Arg Ser 
    1070                 1075                 1080             


Asp Pro  Ser Leu Thr Asn Pro  Pro Ala Thr Ile Gln  Thr Asp Gly 
    1085                 1090                 1095             


Phe Ile  Lys Tyr Gly Lys Ser  Ser Tyr Ser Leu Met  Arg Gln Lys 
    1100                 1105                 1110             


Phe Gln  Trp His Glu Ala Glu  Ile Tyr Cys Lys Leu  His Asn Ser 
    1115                 1120                 1125             


Leu Ile  Ala Ser Ile Leu Asp  Pro Tyr Ser Asn Ala  Phe Ala Trp 
    1130                 1135                 1140             


Leu Gln  Met Glu Thr Ser Asn  Glu Arg Val Trp Ile  Ala Leu Asn 
    1145                 1150                 1155             


Ser Asn  Leu Thr Asp Ser Gln  Tyr Thr Trp Thr Asp  Lys Trp Arg 
    1160                 1165                 1170             


Val Arg  Tyr Thr Asn Trp Ala  Ala Asp Glu Pro Lys  Leu Lys Ser 
    1175                 1180                 1185             


Ala Cys  Ala Tyr Leu Asp Leu  Asp Gly Tyr Trp Lys  Thr Ala Tyr 
    1190                 1195                 1200             


Cys Asn  Glu Ser Phe Tyr Phe  Leu Cys Lys Arg Ser  Asp Glu Ile 
    1205                 1210                 1215             


Pro Ala  Thr Glu Pro Pro Gln  Leu Pro Gly Arg Cys  Pro Glu Ser 
    1220                 1225                 1230             


Asp His  Thr Ala Trp Ile Pro  Phe His Gly His Cys  Tyr Tyr Ile 
    1235                 1240                 1245             


Glu Ser  Ser Tyr Thr Arg Asn  Trp Gly Gln Ala Ser  Leu Glu Cys 
    1250                 1255                 1260             


Leu Arg  Met Gly Ser Ser Leu  Val Ser Ile Glu Ser  Ala Ala Glu 
    1265                 1270                 1275             


Ser Ser  Phe Leu Ser Tyr Arg  Val Glu Pro Leu Lys  Ser Lys Thr 
    1280                 1285                 1290             


Asn Phe  Trp Ile Gly Leu Phe  Arg Asn Val Glu Gly  Met Trp Leu 
    1295                 1300                 1305             


Trp Ile  Asn Asn Ser Pro Val  Ser Phe Val Asn Trp  Asn Thr Gly 
    1310                 1315                 1320             


Asp Pro  Ser Gly Glu Arg Asn  Asp Cys Val Ala Leu  His Ala Ser 
    1325                 1330                 1335             


Ser Gly  Phe Trp Ser Asn Ile  His Cys Ser Ser Tyr  Lys Gly Tyr 
    1340                 1345                 1350             


Ile Cys  Lys Arg Pro Lys Ile  Ile Asp Ala Lys Pro  Thr His Glu 
    1355                 1360                 1365             


Leu Leu  Thr Thr Lys Ala Asp  Thr Arg Lys Met Asp  Pro Ser Lys 
    1370                 1375                 1380             


Pro Ser  Ser Ser Val Ala Gly  Val Val Ile Ile Val  Ile Leu Leu 
    1385                 1390                 1395             


Ile Leu  Thr Gly Ala Gly Leu  Ala Ala Tyr Phe Phe  Tyr Lys Lys 
    1400                 1405                 1410             


Arg Arg  Val His Leu Pro Gln  Glu Gly Ala Phe Glu  Asn Thr Leu 
    1415                 1420                 1425             


Tyr Phe  Asn Ser Gln Ser Ser  Pro Gly Thr Ser Asp  Met Lys Asp 
    1430                 1435                 1440             


Leu Val  Gly Asn Ile Glu Gln  Asn Glu His Ala Val  Ile 
    1445                 1450                 1455     


