                         SEQUENCE LISTING

<110>  INSERM
 
<120>  A SOLUBLE FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) POLYPEPTIDE
        FOR USE IN THE PREVENTION OR TREATMENT OF SKELETAL GROWTH 
       RETARDATION DISORDERS

<130>  12345GOUZE/AS

<160>  2     

<170>  PatentIn version 3.3

<210>  1
<211>  694
<212>  PRT
<213>  Artificial

<220>
<223>  Human soluble FGFR3 polypeptide (sFGFR3)

<400>  1

Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
1               5                   10                  15      


Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val 
            20                  25                  30          


Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln 
        35                  40                  45              


Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro 
    50                  55                  60                  


Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly 
65                  70                  75                  80  


Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val 
                85                  90                  95      


Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg 
            100                 105                 110         


Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala 
        115                 120                 125             


Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr 
    130                 135                 140                 


Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp 
145                 150                 155                 160 


Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys 
                165                 170                 175     


Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly 
            180                 185                 190         


Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 
        195                 200                 205             


Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr 
225                 230                 235                 240 


Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu 
            260                 265                 270         


Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro 
    290                 295                 300                 


Tyr Val Thr Val Leu Lys Val Ser Leu Glu Ser Asn Ala Ser Met Ser 
305                 310                 315                 320 


Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly 
                325                 330                 335     


Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys 
            340                 345                 350         


Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu 
        355                 360                 365             


Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys 
    370                 375                 380                 


Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp 
385                 390                 395                 400 


Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met 
                405                 410                 415     


Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala 
            420                 425                 430         


Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys 
        435                 440                 445             


Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp 
    450                 455                 460                 


Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys 
465                 470                 475                 480 


Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu 
                485                 490                 495     


Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu 
            500                 505                 510         


Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg 
        515                 520                 525             


Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu 
    530                 535                 540                 


Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr 
545                 550                 555                 560 


His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe 
                565                 570                 575     


Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe 
            580                 585                 590         


Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr 
        595                 600                 605             


His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser 
    610                 615                 620                 


Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu 
625                 630                 635                 640 


Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu 
                645                 650                 655     


Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly 
            660                 665                 670         


Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser 
        675                 680                 685             


Ser Gly Gly Ser Arg Thr 
    690                 


<210>  2
<211>  2082
<212>  DNA
<213>  Artificial

<220>
<223>  Human soluble FGFR3 DNA sequence optimized to decrease GC content

<400>  2
atgggcgccc ctgcctgcgc cctcgcgctc tgcgtggccg tggccatcgt ggccggcgcc     60

tcctcggagt ccttggggac ggagcagcgc gtcgtggggc gagcggcaga agtcccgggc    120

ccagagcccg gccagcagga gcagttggtc ttcggcagcg gggatgctgt ggagctgagc    180

tgtcccccgc ccgggggtgg tcccatgggg cccactgtct gggtcaagga tggcacaggg    240

ctggtgccct cggagcgtgt cctggtgggg ccccagcggc tgcaggtgct gaatgcctcc    300

cacgaggact ccggggccta cagctgccgg cagcggctca cgcagcgcgt actgtgccac    360

ttcagtgtgc gggtgacaga cgctccatcc tcgggagatg acgaagacgg ggaggacgag    420

gctgaggaca caggtgtgga cacaggggcc ccttactgga cacggcccga gcggatggac    480

aagaagctgc tggccgtgcc ggccgccaac accgtccgct tccgctgccc agccgctggc    540

aaccccactc cctccatctc ctggctgaag aacggcaggg agttccgcgg cgagcaccgc    600

attggaggca tcaagctgcg gcatcagcag tggagcctgg tcatggaaag cgtggtgccc    660

tcggaccgcg gcaactacac ctgcgtcgtg gagaacaagt ttggcagcat ccggcagacg    720

tacacgctgg acgtgctgga gcgctccccg caccggccca tcctgcaggc ggggctgccg    780

gccaaccaga cggcggtgct gggcagcgac gtggagttcc actgcaaggt gtacagtgac    840

gcacagcccc acatccagtg gctcaagcac gtggaggtga atggcagcaa ggtgggcccg    900

gacggcacac cctacgttac cgtgctcaag gtgtccctgg agtccaacgc gtccatgagc    960

tccaacacac cactggtgcg catcgcaagg ctgtcctcag gggagggccc cacgctggcc   1020

aatgtctccg agctcgagct gcctgccgac cccaaatggg agctgtctcg ggcccggctg   1080

accctgggca agccccttgg ggagggctgc ttcggccagg tggtcatggc ggaggccatc   1140

ggcattgaca aggaccgggc cgccaagcct gtcaccgtag ccgtgaagat gctgaaagac   1200

gatgccactg acaaggacct gtcggacctg gtgtctgaga tggagatgat gaagatgatc   1260

gggaaacaca aaaacatcat caacctgctg ggcgcctgca cgcagggcgg gcccctgtac   1320

gtgctggtgg agtacgcggc caagggtaac ctgcgggagt ttctgcgggc gcggcggccc   1380

ccgggcctgg actactcctt cgacacctgc aagccgcccg aggagcagct caccttcaag   1440

gacctggtgt cctgtgccta ccaggtggcc cggggcatgg agtacttggc ctcccagaag   1500

tgcatccaca gggacctggc tgcccgcaat gtgctggtga ccgaggacaa cgtgatgaag   1560

atcgcagact tcgggctggc ccgggacgtg cacaacctcg actactacaa gaagacaacc   1620

aacggccggc tgcccgtgaa gtggatggcg cctgaggcct tgtttgaccg agtctacact   1680

caccagagtg acgtctggtc ctttggggtc ctgctctggg agatcttcac gctggggggc   1740

tccccgtacc ccggcatccc tgtggaggag ctcttcaagc tgctgaagga gggccaccgc   1800

atggacaagc ccgccaactg cacacacgac ctgtacatga tcatgcggga gtgctggcat   1860

gccgcgccct cccagaggcc caccttcaag cagctggtgg aggacctgga ccgtgtcctt   1920

accgtgacgt ccaccgacga gtacctggac ctgtcggcgc ctttcgagca gtactccccg   1980

ggtggccagg acacccccag ctccagctcc tcaggggacg actccgtgtt tgcccacgac   2040

ctgctgcccc cggccccacc cagcagtggg ggctcgcgga cg                      2082


