                         SEQUENCE LISTING

<110>  ITEK Ventures Pty Ltd
       The University of Melbourne
 
<120>  GENE AND MUTATIONS THEREOF ASSOCIATED WITH SEIZURE DISORDERS

<130>  991113

<150>  2013900208
<151>  2013-01-18

<150>  2013903791
<151>  2013-10-01

<160>  124   

<170>  PatentIn version 3.5

<210>  1
<211>  5551
<212>  DNA
<213>  Homo sapiens

<400>  1
ctagtaggcg cttcaggctt aggggcggaa cagcgcgggc cgcgcgggcg taggcggggt       60

atctggagga ggcgcaggga acctggagag ggtccagccc tcagtgcccc ggccagaggc      120

gggaaggggc tctagagctt cgggaggcaa gatgacttct ctgccccaag cttggaacag      180

ctaaagggaa aaacagtgca agatgagaac aacaaaggtc tagaaactcg tcatccacaa      240

gaagggcttt gggggcagtg atgatgagct agttgtgaac cccaaagtgt tccctcacat      300

caagcttgga gacattgtag agattgcaca ccccaacgat gaatacagcc ctctgctttt      360

gcaggtcaag tctcttaagg aagatttaca gaaggaaact atcagtgtgg accagactgt      420

gactcaagtg ttccggctga gaccttatca ggatgtctat gttaatgtcg tagaccctaa      480

ggatgtgacc cttgacctag tggaattaac ttttaaggat cagtatattg gccgtgggga      540

tatgtggcga ctaaagaaaa gtttggtcag cacatgtgcc tatatcaccc agaaggtgga      600

gtttgctggc atcagagcac aggctggtga actgtgggtt aagaatgaga aggtcatgtg      660

tggctacatc agtgaagata ccagggtggt gtttcgttct acgtcggcta tggtttacat      720

atttattcag atgagctgtg aaatgtggga ttttgatatt tatggggatt tgtattttga      780

gaaagctgtg aatggtttcc ttgctgatct atttaccaag tggaaggaga agaactgtag      840

tcatgaagtg acagtggtcc tgttttctag aactttctat gatgcaaaat ctgttgatga      900

atttcctgaa ataaaccgag cctcaattcg acaggatcac aaggggagat tctatgaaga      960

cttttacaaa gtggtggtgc agaatgagag aagagaagaa tggacttcac ttctcgtaac     1020

cattaaaaaa ctcttcatcc agtatccagt gttggtgcga ctggaacagg cagagggctt     1080

tcctcaagga gataattcta cctcagcaca aggaaactac ctggaggcca tcaatctgtc     1140

attcaatgtg tttgataagc actacatcaa ccgcaacttt gaccgaactg ggcagatgtc     1200

agtggtgatc acgcccgggg tgggtgtctt tgaagtggac cgcctactca tgatcctgac     1260

caagcagcgg atgatagata atggaattgg tgtggatttg gtgtgcatgg gagagcaacc     1320

gttacatgct gtcccattgt tcaagctcca taatcggagt gctccccgtg attctcgtct     1380

gggcgatgac tataatatcc ctcactggat aaaccacagt ttctacacat ccaaaagcca     1440

gctcttttgt aatagtttca ccccacgaat aaaactggca ggaaagaagc ccgcctctga     1500

gaaagcaaaa aatggccgtg atacatctct cgggagtcca aaagaatctg agaacgccct     1560

tcccatccaa gtagattatg acgcctatga cgctcaagtg ttcaggctgc ccggcccatc     1620

ccgggcccag tgcctcacca cctgcagatc tgtgcgagag cgagagagtc acagtcgaaa     1680

gagtgccagc tcctgtgatg tttcatccag cccttcccta ccaagccgca cactgcccac     1740

tgaggaagtg aggagccagg cttctgacga cagctcccta ggcaagagtg ccaacatcct     1800

gatgatccca cacccccacc tgcaccagta tgaagtcagc agctccttgg gatacaccag     1860

cactcgagat gtcctggaga acatgatgga gccaccacag cgagactcca gtgcaccagg     1920

gaggtttcac gttggcagtg cagaatccat gctgcatgtt cgacctggtg gatacacgcc     1980

ccagagagca ctgattaacc ccttcgctcc ctctcggatg cccatgaagc ttacgtccaa     2040

cagaaggcgc tggatgcaca cttttcctgt ggggccatcc ggagaagcca tccagatcca     2100

ccaccagacc cgacagaata tggcggagct acaaggcagc gggcagaggg atccaactca     2160

ctcctctgca gagctgctgg agttagcata tcatgaagct gctggaaggc acagcaattc     2220

ccgccagcct ggtgacggca tgtccttctt gaacttcagt ggaacagagg agctttctgt     2280

cggcctgctt agcaacagtg gtgcaggtat gaatcctagg acccagaata aggattctct     2340

agaggacagt gtttctacct ctccagaccc aattctgaca ctgtctgctc cccctgtagt     2400

gccaggcttc tgttgcacag ttggagtgga ctggaagtct ctcactactc cggcgtgcct     2460

cccccttacc accgactact tccctgaccg ccagggcctg cagaatgact acacagaggg     2520

ctgttatgat ctccttccag aagcagacat cgacaggagg gacgaagatg gtgtgcagat     2580

gacagcccag caggtatttg aagagtttat ttgccaacgt ctcatgcagg gctaccaaat     2640

catagtgcag cccaagacac agaaacccaa tcctgctgtc ccgcccccgc tgagcagtag     2700

cccactctat agccgaggcc ttgtgtcccg aaaccgccct gaggaggagg accagtattg     2760

gctgagtatg ggcagaacgt tccacaaagt gacgctgaag gataagatga tcacagtgac     2820

gcgatacctt cccaagtatc cttatgaatc tgcccagatc cactacacct acagcctctg     2880

tccttcccac tcagactcag agttcgtctc ctgctgggtg gaattctccc acgaacggct     2940

ggaggagtac aagtggaatt acttagatca gtatatctgt tctgccggct ctgaagactt     3000

cagcttaatt gagtccctga agttctggag gacccgcttc ctgctgctgc cagcctgtgt     3060

caccgccacc aagcgcatca cggaggggga ggcccactgc gacatctatg gggacaggcc     3120

ccgtgcagac gaggacgagt ggcaactcct ggatggtttt gtccgctttg tggagggctt     3180

gaatcgcatt cgcaggcggc atcgctcgga tcgcatgatg cggaaaggga ccgccatgaa     3240

aggcttgcag atgactgggc ccatttccac gcattctctg gagtcaactg cacccccagt     3300

ggggaagaag ggaacctcag ctctctctgc cctgttggag atggaggcca gtcagaagtg     3360

cctgggagaa cagcaggcag ctgtgcatgg tgggaagagc tccgcccagt cagccgagag     3420

cagcagcgtt gccatgactc ccacctacat ggacagccca cgaaaggacg gggccttctt     3480

tatggagttt gtccgcagcc cacgcacagc atcgtccgcc ttctaccctc aggtatctgt     3540

ggaccaaaca gccactccta tgttggacgg caccagtttg ggcatatgca caggccaatc     3600

catggacaga ggcaacagcc agacctttgg gaactcccag aacataggag aacagggcta     3660

ctcctccaca aactccagtg acagcagctc tcagcagctg gtggcaagct ccttgacctc     3720

atcctctacc ctgacagaga tcctggaagc catgaagcac ccctcgacag gagtccagct     3780

gctctctgaa cagaagggcc tctcaccgta ctgcttcatc agcgcggagg tggtacactg     3840

gttggtgaac cacgtggagg ggatccagac acaggcgatg gccattgaca tcatgcagaa     3900

aatgctggaa gagcagctca tcacacatgc atctggcgaa gcctggcgga ccttcatcta     3960

cggcttctat ttctacaaga tagtaacgga caaagagccc gaccgagtgg ccatgcagca     4020

gcccgccacc acctggcaca cagcaggagt ggacgacttc gccagcttcc agcgcaagtg     4080

gtttgaggtg gcctttgtgg cagaagagct cgtgcactct gagattcctg cctttctcct     4140

gccctggctg cctagccggc cagcctccta tgcaagtagg cacagctcct ttagccgaag     4200

ttttggagga cggagccagg cggcagcact tttagctgcc actgtcccag agcagaggac     4260

tgtgaccctg gatgttgacg tgaacaaccg cacagaccgg ctggagtggt gcagctgtta     4320

ttaccatggc aacttttctc tgaatgcagc ctttgagatc aagctgcact ggatggcggt     4380

gaccgcagca gtactcttcg agatggtcca aggttggcat cggaaagcca cctcctgtgg     4440

cttcttgtta gtcccagttt tggaggggcc ttttgcactg cccagttacc tgtatggcga     4500

cccccttcgt gcccagctct tcatcccact caacatcagc tgcttgctca aggagggcag     4560

cgagcacctg tttgatagct ttgaacccga aacgtactgg gatcgaatgc acctcttcca     4620

ggaagccatt gcacacaggt ttgggtttgt acaagataaa tattctgcct ctgcttttaa     4680

cttccctgct gagaacaagc ctcagtatat ccacgttaca ggaacagtgt ttctgcagct     4740

gccctactcc aagcgcaagt tctcagggca gcagcggcgg cggcggaact ccaccagctc     4800

caccaaccag aacatgttct gcgaggagcg ggtcggctac aactgggcct acaacaccat     4860

gctcaccaaa acatggcgct ccagcgccac aggggatgaa aagtttgctg atcggctgct     4920

gaaggacttc acggacttct gcatcaaccg tgacaaccgg ctggtcacgt tctggacaag     4980

ttgcctggag aagatgcatg ccagtgcccc gtgaggccag gctgcacctg tgctggggga     5040

aggtgggtga gccactgccc tcaaacccgg ggcggaggat tccaggcagg ctctaggagt     5100

caggtgtccg tttgctgcta tcagtgagtg ggggccattg ttttttgttt gtttgtttgt     5160

ttgtttgttt gtttttggcc cccacgacaa gtcttctact ctagaagaaa gactttggaa     5220

gcagctgctg ctgctgccac cactcctgtc agcaagtgct cagagcaggt gggaggcaca     5280

gattgtccgt gggagggctc cagtgtctgg gaagagggca ggcggccccc atgaatgtcc     5340

tcggaagggg gtggctcctg gtagcatcct tttccttcac catctatggg atattagggg     5400

cagaatctgc cacttcttgc ccaggagtgt gcacagatgt aagataattt tgtgaaataa     5460

tgtaccatag actctcacca actgtatata cctgtacata tcagaagcaa ataaagagct     5520

ccacgtgcat catttctttc cccacccagt t                                    5551


<210>  2
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Thr Thr Lys Val 
1               5       


<210>  3
<211>  5551
<212>  DNA
<213>  Homo sapiens

<400>  3
ctagtaggcg cttcaggctt aggggcggaa cagcgcgggc cgcgcgggcg taggcggggt       60

atctggagga ggcgcaggga acctggagag ggtccagccc tcagtgcccc ggccagaggc      120

gggaaggggc tctagagctt cgggaggcaa gatgacttct ctgccccaag cttggaacag      180

ctaaagggaa aaacagtgca agatgagaac aacaaaggtc tacaaactcg tcatccacaa      240

gaagggcttt gggggcagtg atgatgagct agttgtgaac cccaaagtgt tccctcacat      300

caagcttgga gacattgtag agattgcaca ccccaacgat gaatacagcc ctctgctttt      360

gcaggtcaag tctcttaagg aagatttaca gaaggaaact atcagtgtgg accagactgt      420

gactcaagtg ttccggctga gaccttatca ggatgtctat gttaatgtcg tagaccctaa      480

ggatgtgacc cttgacctag tggaattaac ttttaaggat cagtatattg gccgtgggga      540

tatgtggcga ctaaagaaaa gtttggtcag cacatgtgcc tatatcaccc agaaggtgga      600

gtttgctggc atcagagcac aggctggtga actgtgggtt aagaatgaga aggtcatgtg      660

tggctacatc agtgaagata ccagggtggt gtttcgttct acgtcggcta tggtttacat      720

atttattcag atgagctgtg aaatgtggga ttttgatatt tatggggatt tgtattttga      780

gaaagctgtg aatggtttcc ttgctgatct atttaccaag tggaaggaga agaactgtag      840

tcatgaagtg acagtggtcc tgttttctag aactttctat gatgcaaaat ctgttgatga      900

atttcctgaa ataaaccgag cctcaattcg acaggatcac aaggggagat tctatgaaga      960

cttttacaaa gtggtggtgc agaatgagag aagagaagaa tggacttcac ttctcgtaac     1020

cattaaaaaa ctcttcatcc agtatccagt gttggtgcga ctggaacagg cagagggctt     1080

tcctcaagga gataattcta cctcagcaca aggaaactac ctggaggcca tcaatctgtc     1140

attcaatgtg tttgataagc actacatcaa ccgcaacttt gaccgaactg ggcagatgtc     1200

agtggtgatc acgcccgggg tgggtgtctt tgaagtggac cgcctactca tgatcctgac     1260

caagcagcgg atgatagata atggaattgg tgtggatttg gtgtgcatgg gagagcaacc     1320

gttacatgct gtcccattgt tcaagctcca taatcggagt gctccccgtg attctcgtct     1380

gggcgatgac tataatatcc ctcactggat aaaccacagt ttctacacat ccaaaagcca     1440

gctcttttgt aatagtttca ccccacgaat aaaactggca ggaaagaagc ccgcctctga     1500

gaaagcaaaa aatggccgtg atacatctct cgggagtcca aaagaatctg agaacgccct     1560

tcccatccaa gtagattatg acgcctatga cgctcaagtg ttcaggctgc ccggcccatc     1620

ccgggcccag tgcctcacca cctgcagatc tgtgcgagag cgagagagtc acagtcgaaa     1680

gagtgccagc tcctgtgatg tttcatccag cccttcccta ccaagccgca cactgcccac     1740

tgaggaagtg aggagccagg cttctgacga cagctcccta ggcaagagtg ccaacatcct     1800

gatgatccca cacccccacc tgcaccagta tgaagtcagc agctccttgg gatacaccag     1860

cacttgagat gtcctggaga acatgatgga gccaccacag cgagactcca gtgcaccagg     1920

gaggtttcac gttggcagtg cagaatccat gctgcatgtt cgacctggtg gatacacgcc     1980

ccagagagca ctgattaacc ccttcgctcc ctctcggatg cccatgaagc ttacgtccaa     2040

cagaaggcgc tggatgcaca cttttcctgt ggggccatcc ggagaagcca tccagatcca     2100

ccaccagacc cgacagaata tggcggagct acaaggcagc gggcagaggg atccaactca     2160

ctcctctgca gagctgctgg agttagcata tcatgaagct gctggaaggc acagcaattc     2220

ccgccagcct ggtgacggca tgtccttctt gaacttcagt ggaacagagg agctttctgt     2280

cggcctgctt agcaacagtg gtgcaggtat gaatcctagg acccagaata aggattctct     2340

agaggacagt gtttctacct ctccagaccc aattctgaca ctgtctgctc cccctgtagt     2400

gccaggcttc tgttgcacag ttggagtgga ctggaagtct ctcactactc cggcgtgcct     2460

cccccttacc accgactact tccctgaccg ccagggcctg cagaatgact acacagaggg     2520

ctgttatgat ctccttccag aagcagacat cgacaggagg gacgaagatg gtgtgcagat     2580

gacagcccag caggtatttg aagagtttat ttgccaacgt ctcatgcagg gctaccaaat     2640

catagtgcag cccaagacac agaaacccaa tcctgctgtc ccgcccccgc tgagcagtag     2700

cccactctat agccgaggcc ttgtgtcccg aaaccgccct gaggaggagg accagtattg     2760

gctgagtatg ggcagaacgt tccacaaagt gacgctgaag gataagatga tcacagtgac     2820

gcgatacctt cccaagtatc cttatgaatc tgcccagatc cactacacct acagcctctg     2880

tccttcccac tcagactcag agttcgtctc ctgctgggtg gaattctccc acgaacggct     2940

ggaggagtac aagtggaatt acttagatca gtatatctgt tctgccggct ctgaagactt     3000

cagcttaatt gagtccctga agttctggag gacccgcttc ctgctgctgc cagcctgtgt     3060

caccgccacc aagcgcatca cggaggggga ggcccactgc gacatctatg gggacaggcc     3120

ccgtgcagac gaggacgagt ggcaactcct ggatggtttt gtccgctttg tggagggctt     3180

gaatcgcatt cgcaggcggc atcgctcgga tcgcatgatg cggaaaggga ccgccatgaa     3240

aggcttgcag atgactgggc ccatttccac gcattctctg gagtcaactg cacccccagt     3300

ggggaagaag ggaacctcag ctctctctgc cctgttggag atggaggcca gtcagaagtg     3360

cctgggagaa cagcaggcag ctgtgcatgg tgggaagagc tccgcccagt cagccgagag     3420

cagcagcgtt gccatgactc ccacctacat ggacagccca cgaaaggacg gggccttctt     3480

tatggagttt gtccgcagcc cacgcacagc atcgtccgcc ttctaccctc aggtatctgt     3540

ggaccaaaca gccactccta tgttggacgg caccagtttg ggcatatgca caggccaatc     3600

catggacaga ggcaacagcc agacctttgg gaactcccag aacataggag aacagggcta     3660

ctcctccaca aactccagtg acagcagctc tcagcagctg gtggcaagct ccttgacctc     3720

atcctctacc ctgacagaga tcctggaagc catgaagcac ccctcgacag gagtccagct     3780

gctctctgaa cagaagggcc tctcaccgta ctgcttcatc agcgcggagg tggtacactg     3840

gttggtgaac cacgtggagg ggatccagac acaggcgatg gccattgaca tcatgcagaa     3900

aatgctggaa gagcagctca tcacacatgc atctggcgaa gcctggcgga ccttcatcta     3960

cggcttctat ttctacaaga tagtaacgga caaagagccc gaccgagtgg ccatgcagca     4020

gcccgccacc acctggcaca cagcaggagt ggacgacttc gccagcttcc agcgcaagtg     4080

gtttgaggtg gcctttgtgg cagaagagct cgtgcactct gagattcctg cctttctcct     4140

gccctggctg cctagccggc cagcctccta tgcaagtagg cacagctcct ttagccgaag     4200

ttttggagga cggagccagg cggcagcact tttagctgcc actgtcccag agcagaggac     4260

tgtgaccctg gatgttgacg tgaacaaccg cacagaccgg ctggagtggt gcagctgtta     4320

ttaccatggc aacttttctc tgaatgcagc ctttgagatc aagctgcact ggatggcggt     4380

gaccgcagca gtactcttcg agatggtcca aggttggcat cggaaagcca cctcctgtgg     4440

cttcttgtta gtcccagttt tggaggggcc ttttgcactg cccagttacc tgtatggcga     4500

cccccttcgt gcccagctct tcatcccact caacatcagc tgcttgctca aggagggcag     4560

cgagcacctg tttgatagct ttgaacccga aacgtactgg gatcgaatgc acctcttcca     4620

ggaagccatt gcacacaggt ttgggtttgt acaagataaa tattctgcct ctgcttttaa     4680

cttccctgct gagaacaagc ctcagtatat ccacgttaca ggaacagtgt ttctgcagct     4740

gccctactcc aagcgcaagt tctcagggca gcagcggcgg cggcggaact ccaccagctc     4800

caccaaccag aacatgttct gcgaggagcg ggtcggctac aactgggcct acaacaccat     4860

gctcaccaaa acatggcgct ccagcgccac aggggatgaa aagtttgctg atcggctgct     4920

gaaggacttc acggacttct gcatcaaccg tgacaaccgg ctggtcacgt tctggacaag     4980

ttgcctggag aagatgcatg ccagtgcccc gtgaggccag gctgcacctg tgctggggga     5040

aggtgggtga gccactgccc tcaaacccgg ggcggaggat tccaggcagg ctctaggagt     5100

caggtgtccg tttgctgcta tcagtgagtg ggggccattg ttttttgttt gtttgtttgt     5160

ttgtttgttt gtttttggcc cccacgacaa gtcttctact ctagaagaaa gactttggaa     5220

gcagctgctg ctgctgccac cactcctgtc agcaagtgct cagagcaggt gggaggcaca     5280

gattgtccgt gggagggctc cagtgtctgg gaagagggca ggcggccccc atgaatgtcc     5340

tcggaagggg gtggctcctg gtagcatcct tttccttcac catctatggg atattagggg     5400

cagaatctgc cacttcttgc ccaggagtgt gcacagatgt aagataattt tgtgaaataa     5460

tgtaccatag actctcacca actgtatata cctgtacata tcagaagcaa ataaagagct     5520

ccacgtgcat catttctttc cccacccagt t                                    5551


<210>  4
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Thr Thr Lys Val Tyr Lys Leu Val Ile His Lys Lys Gly Phe 
1               5                   10                  15      


Gly Gly Ser Asp Asp Glu Leu Val Val Asn Pro Lys Val Phe Pro His 
            20                  25                  30          


Ile Lys Leu Gly Asp Ile Val Glu Ile Ala His Pro Asn Asp Glu Tyr 
        35                  40                  45              


Ser Pro Leu Leu Leu Gln Val Lys Ser Leu Lys Glu Asp Leu Gln Lys 
    50                  55                  60                  


Glu Thr Ile Ser Val Asp Gln Thr Val Thr Gln Val Phe Arg Leu Arg 
65                  70                  75                  80  


Pro Tyr Gln Asp Val Tyr Val Asn Val Val Asp Pro Lys Asp Val Thr 
                85                  90                  95      


Leu Asp Leu Val Glu Leu Thr Phe Lys Asp Gln Tyr Ile Gly Arg Gly 
            100                 105                 110         


Asp Met Trp Arg Leu Lys Lys Ser Leu Val Ser Thr Cys Ala Tyr Ile 
        115                 120                 125             


Thr Gln Lys Val Glu Phe Ala Gly Ile Arg Ala Gln Ala Gly Glu Leu 
    130                 135                 140                 


Trp Val Lys Asn Glu Lys Val Met Cys Gly Tyr Ile Ser Glu Asp Thr 
145                 150                 155                 160 


Arg Val Val Phe Arg Ser Thr Ser Ala Met Val Tyr Ile Phe Ile Gln 
                165                 170                 175     


Met Ser Cys Glu Met Trp Asp Phe Asp Ile Tyr Gly Asp Leu Tyr Phe 
            180                 185                 190         


Glu Lys Ala Val Asn Gly Phe Leu Ala Asp Leu Phe Thr Lys Trp Lys 
        195                 200                 205             


Glu Lys Asn Cys Ser His Glu Val Thr Val Val Leu Phe Ser Arg Thr 
    210                 215                 220                 


Phe Tyr Asp Ala Lys Ser Val Asp Glu Phe Pro Glu Ile Asn Arg Ala 
225                 230                 235                 240 


Ser Ile Arg Gln Asp His Lys Gly Arg Phe Tyr Glu Asp Phe Tyr Lys 
                245                 250                 255     


Val Val Val Gln Asn Glu Arg Arg Glu Glu Trp Thr Ser Leu Leu Val 
            260                 265                 270         


Thr Ile Lys Lys Leu Phe Ile Gln Tyr Pro Val Leu Val Arg Leu Glu 
        275                 280                 285             


Gln Ala Glu Gly Phe Pro Gln Gly Asp Asn Ser Thr Ser Ala Gln Gly 
    290                 295                 300                 


Asn Tyr Leu Glu Ala Ile Asn Leu Ser Phe Asn Val Phe Asp Lys His 
305                 310                 315                 320 


Tyr Ile Asn Arg Asn Phe Asp Arg Thr Gly Gln Met Ser Val Val Ile 
                325                 330                 335     


Thr Pro Gly Val Gly Val Phe Glu Val Asp Arg Leu Leu Met Ile Leu 
            340                 345                 350         


Thr Lys Gln Arg Met Ile Asp Asn Gly Ile Gly Val Asp Leu Val Cys 
        355                 360                 365             


Met Gly Glu Gln Pro Leu His Ala Val Pro Leu Phe Lys Leu His Asn 
    370                 375                 380                 


Arg Ser Ala Pro Arg Asp Ser Arg Leu Gly Asp Asp Tyr Asn Ile Pro 
385                 390                 395                 400 


His Trp Ile Asn His Ser Phe Tyr Thr Ser Lys Ser Gln Leu Phe Cys 
                405                 410                 415     


Asn Ser Phe Thr Pro Arg Ile Lys Leu Ala Gly Lys Lys Pro Ala Ser 
            420                 425                 430         


Glu Lys Ala Lys Asn Gly Arg Asp Thr Ser Leu Gly Ser Pro Lys Glu 
        435                 440                 445             


Ser Glu Asn Ala Leu Pro Ile Gln Val Asp Tyr Asp Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Val Phe Arg Leu Pro Gly Pro Ser Arg Ala Gln Cys Leu Thr Thr 
465                 470                 475                 480 


Cys Arg Ser Val Arg Glu Arg Glu Ser His Ser Arg Lys Ser Ala Ser 
                485                 490                 495     


Ser Cys Asp Val Ser Ser Ser Pro Ser Leu Pro Ser Arg Thr Leu Pro 
            500                 505                 510         


Thr Glu Glu Val Arg Ser Gln Ala Ser Asp Asp Ser Ser Leu Gly Lys 
        515                 520                 525             


Ser Ala Asn Ile Leu Met Ile Pro His Pro His Leu His Gln Tyr Glu 
    530                 535                 540                 


Val Ser Ser Ser Leu Gly Tyr Thr Ser Thr 
545                 550                 


<210>  5
<211>  5551
<212>  DNA
<213>  Homo sapiens

<400>  5
ctagtaggcg cttcaggctt aggggcggaa cagcgcgggc cgcgcgggcg taggcggggt       60

atctggagga ggcgcaggga acctggagag ggtccagccc tcagtgcccc ggccagaggc      120

gggaaggggc tctagagctt cgggaggcaa gatgacttct ctgccccaag cttggaacag      180

ctaaagggaa aaacagtgca agatgagaac aacaaaggtc tacaaactcg tcatccacaa      240

gaagggcttt gggggcagtg atgatgagct agttgtgaac cccaaagtgt tccctcacat      300

caagcttgga gacattgtag agattgcaca ccccaacgat gaatacagcc ctctgctttt      360

gcaggtcaag tctcttaagg aagatttaca gaaggaaact atcagtgtgg accagactgt      420

gactcaagtg ttccggctga gaccttatca ggatgtctat gttaatgtcg tagaccctaa      480

ggatgtgacc cttgacctag tggaattaac ttttaaggat cagtatattg gccgtgggga      540

tatgtggcga ctaaagaaaa gtttggtcag cacatgtgcc tatatcaccc agaaggtgga      600

gtttgctggc atcagagcac aggctggtga actgtgggtt aagaatgaga aggtcatgtg      660

tggctacatc agtgaagata ccagggtggt gtttcgttct acgtcggcta tggtttacat      720

atttattcag atgagctgtg aaatgtggga ttttgatatt tatggggatt tgtattttga      780

gaaagctgtg aatggtttcc ttgctgatct atttaccaag tggaaggaga agaactgtag      840

tcatgaagtg acagtggtcc tgttttctag aactttctat gatgcaaaat ctgttgatga      900

atttcctgaa ataaaccgag cctcaattcg acaggatcac aaggggagat tctatgaaga      960

cttttacaaa gtggtggtgc agaatgagag aagagaagaa tggacttcac ttctcgtaac     1020

cattaaaaaa ctcttcatcc agtatccagt gttggtgcga ctggaacagg cagagggctt     1080

tcctcaagga gataattcta cctcagcaca aggaaactac ctggaggcca tcaatctgtc     1140

attcaatgtg tttgataagc actacatcaa ccgcaacttt gaccgaactg ggcagatgtc     1200

agtggtgatc acgcccgggg tgggtgtctt tgaagtggac cgcctactca tgatcctgac     1260

caagcagcgg atgatagata atggaattgg tgtggatttg gtgtgcatgg gagagcaacc     1320

gttacatgct gtcccattgt tcaagctcca taatcggagt gctccccgtg attctcgtct     1380

gggcgatgac tataatatcc ctcactggat aaaccacagt ttctacacat ccaaaagcca     1440

gctcttttgt aatagtttca ccccacgaat aaaactggca ggaaagaagc ccgcctctga     1500

gaaagcaaaa aatggccgtg atacatctct cgggagtcca aaagaatctg agaacgccct     1560

tcccatccaa gtagattatg acgcctatga cgctcaagtg ttcaggctgc ccggcccatc     1620

ccgggcccag tgcctcacca cctgcagatc tgtgcgagag cgagagagtc acagtcgaaa     1680

gagtgccagc tcctgtgatg tttcatccag cccttcccta ccaagccgca cactgcccac     1740

tgaggaagtg aggagccagg cttctgacga cagctcccta ggcaagagtg ccaacatcct     1800

gatgatccca cacccccacc tgcaccagta tgaagtcagc agctccttgg gatacaccag     1860

cactcgagat gtcctggaga acatgatgga gccaccacag cgagactcca gtgcaccagg     1920

gaggtttcac gttggcagtg cagaatccat gctgcatgtt cgacctggtg gatacacgcc     1980

ccagagagca ctgattaacc ccttcgctcc ctctcggatg cccatgaagc ttacgtccaa     2040

cagaaggcgc tggatgcaca cttttcctgt ggggccatcc ggagaagcca tccagatcca     2100

ccaccagacc cgacagaata tggcggagct acaaggcagc gggcagaggg atccaactca     2160

ctcctctgca gagctgctgg agttagcata tcatgaagct gctggaaggc acagcaattc     2220

ccgccagcct ggtgacggca tgtccttctt gaacttcagt ggaacagagg agctttctgt     2280

cggcctgctt agcaacagtg gtgcaggtat gaatcctagg acccagaata aggattctct     2340

agaggacagt gtttctacct ctccagaccc aattctgaca ctgtctgctc cccctgtagt     2400

gccaggcttc tgttgcacag ttggagtgga ctggaagtct ctcactactc cggcgtgcct     2460

cccccttacc accgactact tccctgaccg ccagggcctg cagaatgact acacagaggg     2520

ctgttatgat ctccttccag aagcagacat cgacaggagg gacgaagatg gtgtgcagat     2580

gacagcccag caggtatttg aagagtttat ttgccaacgt ctcatgcagg gctaccaaat     2640

catagtgcag cccaagacac agaaacccaa tcctgctgtc ccgcccccgc tgagcagtag     2700

cccactctat agccgaggcc ttgtgtcccg aaaccgccct gaggaggagg accagtattg     2760

gctgagtatg ggcagaacgt tccacaaagt gacgctgaag gataagatga tcacagtgac     2820

gcgatacctt cccaagtatc cttatgaatc tgcccagatc cactacacct acagcctctg     2880

tccttcccac tcagactcag agttcgtctc ctgctgggtg gaattctccc acgaacggct     2940

ggaggagtac aagtggaatt acttagatca gtatatctgt tctgccggct ctgaagactt     3000

cagcttaatt gagtccctga agttctggag gacccgcttc ctgctgctgc cagcctgtgt     3060

caccgccacc aagcgcatca cggaggggga ggcccactgc gacatctatg gggacaggcc     3120

ccgtgcagac gaggacgagt ggcaactcct ggatggtttt gtccgctttg tggagggctt     3180

gaatcgcatt cgcaggcggc atcgctcgga tcgcatgatg cggaaaggga ccgccatgaa     3240

aggcttgcag atgactgggc ccatttccac gcattctctg gagtcaactg cacccccagt     3300

ggggaagaag ggaacctcag ctctctctgc cctgttggag atggaggcca gtcagaagtg     3360

cctgggagaa cagcaggcag ctgtgcatgg tgggaagagc tccgcccagt cagccgagag     3420

cagcagcgtt gccatgactc ccacctacat ggacagccca cgaaaggacg gggccttctt     3480

tatggagttt gtccgcagcc cacgcacagc atcgtccgcc ttctaccctc aggtatctgt     3540

ggaccaaaca gccactccta tgttggacgg caccagtttg ggcatatgca caggccaatc     3600

catggacaga ggcaacagcc agacctttgg gaactcccag aacataggag aacagggcta     3660

ctcctccaca aactccagtg acagcagctc tcagcagctg gtggcaagct ccttgacctc     3720

atcctctacc ctgacagaga tcctggaagc catgaagcac ccctcgacag gagtccagct     3780

gctctctgaa cagaagggcc tctcaccgta ctgcttcatc agcgcggagg tggtacactg     3840

gttggtgaac cacgtggagg ggatccagac acaggcgatg gccattgaca tcatgcagaa     3900

aatgctggaa gagcagctca tcacacatgc atctggcgaa gcctggcgga ccttcatcta     3960

cggcttctat ttctacaaga tagtaacgga caaagagccc gaccgagtgg ccatgcagca     4020

gcccgccacc acctggcaca cagcaggagt ggacgacttc gccagcttcc agcgcaagtg     4080

gtttgaggtg gcctttgtgg cagaagagct cgtgcactct gagattcctg cctttctcct     4140

gccctggctg cctagccggc cagcctccta tgcaagtagg cacagctcct ttagccgaag     4200

ttttggagga cggagccagg cggcagcact tttagctgcc actgtcccag agcagaggac     4260

tgtgaccctg gatgttgacg tgaacaaccg cacagaccgg ctggagtgat gcagctgtta     4320

ttaccatggc aacttttctc tgaatgcagc ctttgagatc aagctgcact ggatggcggt     4380

gaccgcagca gtactcttcg agatggtcca aggttggcat cggaaagcca cctcctgtgg     4440

cttcttgtta gtcccagttt tggaggggcc ttttgcactg cccagttacc tgtatggcga     4500

cccccttcgt gcccagctct tcatcccact caacatcagc tgcttgctca aggagggcag     4560

cgagcacctg tttgatagct ttgaacccga aacgtactgg gatcgaatgc acctcttcca     4620

ggaagccatt gcacacaggt ttgggtttgt acaagataaa tattctgcct ctgcttttaa     4680

cttccctgct gagaacaagc ctcagtatat ccacgttaca ggaacagtgt ttctgcagct     4740

gccctactcc aagcgcaagt tctcagggca gcagcggcgg cggcggaact ccaccagctc     4800

caccaaccag aacatgttct gcgaggagcg ggtcggctac aactgggcct acaacaccat     4860

gctcaccaaa acatggcgct ccagcgccac aggggatgaa aagtttgctg atcggctgct     4920

gaaggacttc acggacttct gcatcaaccg tgacaaccgg ctggtcacgt tctggacaag     4980

ttgcctggag aagatgcatg ccagtgcccc gtgaggccag gctgcacctg tgctggggga     5040

aggtgggtga gccactgccc tcaaacccgg ggcggaggat tccaggcagg ctctaggagt     5100

caggtgtccg tttgctgcta tcagtgagtg ggggccattg ttttttgttt gtttgtttgt     5160

ttgtttgttt gtttttggcc cccacgacaa gtcttctact ctagaagaaa gactttggaa     5220

gcagctgctg ctgctgccac cactcctgtc agcaagtgct cagagcaggt gggaggcaca     5280

gattgtccgt gggagggctc cagtgtctgg gaagagggca ggcggccccc atgaatgtcc     5340

tcggaagggg gtggctcctg gtagcatcct tttccttcac catctatggg atattagggg     5400

cagaatctgc cacttcttgc ccaggagtgt gcacagatgt aagataattt tgtgaaataa     5460

tgtaccatag actctcacca actgtatata cctgtacata tcagaagcaa ataaagagct     5520

ccacgtgcat catttctttc cccacccagt t                                    5551


<210>  6
<211>  1368
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Thr Thr Lys Val Tyr Lys Leu Val Ile His Lys Lys Gly Phe 
1               5                   10                  15      


Gly Gly Ser Asp Asp Glu Leu Val Val Asn Pro Lys Val Phe Pro His 
            20                  25                  30          


Ile Lys Leu Gly Asp Ile Val Glu Ile Ala His Pro Asn Asp Glu Tyr 
        35                  40                  45              


Ser Pro Leu Leu Leu Gln Val Lys Ser Leu Lys Glu Asp Leu Gln Lys 
    50                  55                  60                  


Glu Thr Ile Ser Val Asp Gln Thr Val Thr Gln Val Phe Arg Leu Arg 
65                  70                  75                  80  


Pro Tyr Gln Asp Val Tyr Val Asn Val Val Asp Pro Lys Asp Val Thr 
                85                  90                  95      


Leu Asp Leu Val Glu Leu Thr Phe Lys Asp Gln Tyr Ile Gly Arg Gly 
            100                 105                 110         


Asp Met Trp Arg Leu Lys Lys Ser Leu Val Ser Thr Cys Ala Tyr Ile 
        115                 120                 125             


Thr Gln Lys Val Glu Phe Ala Gly Ile Arg Ala Gln Ala Gly Glu Leu 
    130                 135                 140                 


Trp Val Lys Asn Glu Lys Val Met Cys Gly Tyr Ile Ser Glu Asp Thr 
145                 150                 155                 160 


Arg Val Val Phe Arg Ser Thr Ser Ala Met Val Tyr Ile Phe Ile Gln 
                165                 170                 175     


Met Ser Cys Glu Met Trp Asp Phe Asp Ile Tyr Gly Asp Leu Tyr Phe 
            180                 185                 190         


Glu Lys Ala Val Asn Gly Phe Leu Ala Asp Leu Phe Thr Lys Trp Lys 
        195                 200                 205             


Glu Lys Asn Cys Ser His Glu Val Thr Val Val Leu Phe Ser Arg Thr 
    210                 215                 220                 


Phe Tyr Asp Ala Lys Ser Val Asp Glu Phe Pro Glu Ile Asn Arg Ala 
225                 230                 235                 240 


Ser Ile Arg Gln Asp His Lys Gly Arg Phe Tyr Glu Asp Phe Tyr Lys 
                245                 250                 255     


Val Val Val Gln Asn Glu Arg Arg Glu Glu Trp Thr Ser Leu Leu Val 
            260                 265                 270         


Thr Ile Lys Lys Leu Phe Ile Gln Tyr Pro Val Leu Val Arg Leu Glu 
        275                 280                 285             


Gln Ala Glu Gly Phe Pro Gln Gly Asp Asn Ser Thr Ser Ala Gln Gly 
    290                 295                 300                 


Asn Tyr Leu Glu Ala Ile Asn Leu Ser Phe Asn Val Phe Asp Lys His 
305                 310                 315                 320 


Tyr Ile Asn Arg Asn Phe Asp Arg Thr Gly Gln Met Ser Val Val Ile 
                325                 330                 335     


Thr Pro Gly Val Gly Val Phe Glu Val Asp Arg Leu Leu Met Ile Leu 
            340                 345                 350         


Thr Lys Gln Arg Met Ile Asp Asn Gly Ile Gly Val Asp Leu Val Cys 
        355                 360                 365             


Met Gly Glu Gln Pro Leu His Ala Val Pro Leu Phe Lys Leu His Asn 
    370                 375                 380                 


Arg Ser Ala Pro Arg Asp Ser Arg Leu Gly Asp Asp Tyr Asn Ile Pro 
385                 390                 395                 400 


His Trp Ile Asn His Ser Phe Tyr Thr Ser Lys Ser Gln Leu Phe Cys 
                405                 410                 415     


Asn Ser Phe Thr Pro Arg Ile Lys Leu Ala Gly Lys Lys Pro Ala Ser 
            420                 425                 430         


Glu Lys Ala Lys Asn Gly Arg Asp Thr Ser Leu Gly Ser Pro Lys Glu 
        435                 440                 445             


Ser Glu Asn Ala Leu Pro Ile Gln Val Asp Tyr Asp Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Val Phe Arg Leu Pro Gly Pro Ser Arg Ala Gln Cys Leu Thr Thr 
465                 470                 475                 480 


Cys Arg Ser Val Arg Glu Arg Glu Ser His Ser Arg Lys Ser Ala Ser 
                485                 490                 495     


Ser Cys Asp Val Ser Ser Ser Pro Ser Leu Pro Ser Arg Thr Leu Pro 
            500                 505                 510         


Thr Glu Glu Val Arg Ser Gln Ala Ser Asp Asp Ser Ser Leu Gly Lys 
        515                 520                 525             


Ser Ala Asn Ile Leu Met Ile Pro His Pro His Leu His Gln Tyr Glu 
    530                 535                 540                 


Val Ser Ser Ser Leu Gly Tyr Thr Ser Thr Arg Asp Val Leu Glu Asn 
545                 550                 555                 560 


Met Met Glu Pro Pro Gln Arg Asp Ser Ser Ala Pro Gly Arg Phe His 
                565                 570                 575     


Val Gly Ser Ala Glu Ser Met Leu His Val Arg Pro Gly Gly Tyr Thr 
            580                 585                 590         


Pro Gln Arg Ala Leu Ile Asn Pro Phe Ala Pro Ser Arg Met Pro Met 
        595                 600                 605             


Lys Leu Thr Ser Asn Arg Arg Arg Trp Met His Thr Phe Pro Val Gly 
    610                 615                 620                 


Pro Ser Gly Glu Ala Ile Gln Ile His His Gln Thr Arg Gln Asn Met 
625                 630                 635                 640 


Ala Glu Leu Gln Gly Ser Gly Gln Arg Asp Pro Thr His Ser Ser Ala 
                645                 650                 655     


Glu Leu Leu Glu Leu Ala Tyr His Glu Ala Ala Gly Arg His Ser Asn 
            660                 665                 670         


Ser Arg Gln Pro Gly Asp Gly Met Ser Phe Leu Asn Phe Ser Gly Thr 
        675                 680                 685             


Glu Glu Leu Ser Val Gly Leu Leu Ser Asn Ser Gly Ala Gly Met Asn 
    690                 695                 700                 


Pro Arg Thr Gln Asn Lys Asp Ser Leu Glu Asp Ser Val Ser Thr Ser 
705                 710                 715                 720 


Pro Asp Pro Ile Leu Thr Leu Ser Ala Pro Pro Val Val Pro Gly Phe 
                725                 730                 735     


Cys Cys Thr Val Gly Val Asp Trp Lys Ser Leu Thr Thr Pro Ala Cys 
            740                 745                 750         


Leu Pro Leu Thr Thr Asp Tyr Phe Pro Asp Arg Gln Gly Leu Gln Asn 
        755                 760                 765             


Asp Tyr Thr Glu Gly Cys Tyr Asp Leu Leu Pro Glu Ala Asp Ile Asp 
    770                 775                 780                 


Arg Arg Asp Glu Asp Gly Val Gln Met Thr Ala Gln Gln Val Phe Glu 
785                 790                 795                 800 


Glu Phe Ile Cys Gln Arg Leu Met Gln Gly Tyr Gln Ile Ile Val Gln 
                805                 810                 815     


Pro Lys Thr Gln Lys Pro Asn Pro Ala Val Pro Pro Pro Leu Ser Ser 
            820                 825                 830         


Ser Pro Leu Tyr Ser Arg Gly Leu Val Ser Arg Asn Arg Pro Glu Glu 
        835                 840                 845             


Glu Asp Gln Tyr Trp Leu Ser Met Gly Arg Thr Phe His Lys Val Thr 
    850                 855                 860                 


Leu Lys Asp Lys Met Ile Thr Val Thr Arg Tyr Leu Pro Lys Tyr Pro 
865                 870                 875                 880 


Tyr Glu Ser Ala Gln Ile His Tyr Thr Tyr Ser Leu Cys Pro Ser His 
                885                 890                 895     


Ser Asp Ser Glu Phe Val Ser Cys Trp Val Glu Phe Ser His Glu Arg 
            900                 905                 910         


Leu Glu Glu Tyr Lys Trp Asn Tyr Leu Asp Gln Tyr Ile Cys Ser Ala 
        915                 920                 925             


Gly Ser Glu Asp Phe Ser Leu Ile Glu Ser Leu Lys Phe Trp Arg Thr 
    930                 935                 940                 


Arg Phe Leu Leu Leu Pro Ala Cys Val Thr Ala Thr Lys Arg Ile Thr 
945                 950                 955                 960 


Glu Gly Glu Ala His Cys Asp Ile Tyr Gly Asp Arg Pro Arg Ala Asp 
                965                 970                 975     


Glu Asp Glu Trp Gln Leu Leu Asp Gly Phe Val Arg Phe Val Glu Gly 
            980                 985                 990         


Leu Asn Arg Ile Arg Arg Arg His  Arg Ser Asp Arg Met  Met Arg Lys 
        995                 1000                 1005             


Gly Thr  Ala Met Lys Gly Leu  Gln Met Thr Gly Pro  Ile Ser Thr 
    1010                 1015                 1020             


His Ser  Leu Glu Ser Thr Ala  Pro Pro Val Gly Lys  Lys Gly Thr 
    1025                 1030                 1035             


Ser Ala  Leu Ser Ala Leu Leu  Glu Met Glu Ala Ser  Gln Lys Cys 
    1040                 1045                 1050             


Leu Gly  Glu Gln Gln Ala Ala  Val His Gly Gly Lys  Ser Ser Ala 
    1055                 1060                 1065             


Gln Ser  Ala Glu Ser Ser Ser  Val Ala Met Thr Pro  Thr Tyr Met 
    1070                 1075                 1080             


Asp Ser  Pro Arg Lys Asp Gly  Ala Phe Phe Met Glu  Phe Val Arg 
    1085                 1090                 1095             


Ser Pro  Arg Thr Ala Ser Ser  Ala Phe Tyr Pro Gln  Val Ser Val 
    1100                 1105                 1110             


Asp Gln  Thr Ala Thr Pro Met  Leu Asp Gly Thr Ser  Leu Gly Ile 
    1115                 1120                 1125             


Cys Thr  Gly Gln Ser Met Asp  Arg Gly Asn Ser Gln  Thr Phe Gly 
    1130                 1135                 1140             


Asn Ser  Gln Asn Ile Gly Glu  Gln Gly Tyr Ser Ser  Thr Asn Ser 
    1145                 1150                 1155             


Ser Asp  Ser Ser Ser Gln Gln  Leu Val Ala Ser Ser  Leu Thr Ser 
    1160                 1165                 1170             


Ser Ser  Thr Leu Thr Glu Ile  Leu Glu Ala Met Lys  His Pro Ser 
    1175                 1180                 1185             


Thr Gly  Val Gln Leu Leu Ser  Glu Gln Lys Gly Leu  Ser Pro Tyr 
    1190                 1195                 1200             


Cys Phe  Ile Ser Ala Glu Val  Val His Trp Leu Val  Asn His Val 
    1205                 1210                 1215             


Glu Gly  Ile Gln Thr Gln Ala  Met Ala Ile Asp Ile  Met Gln Lys 
    1220                 1225                 1230             


Met Leu  Glu Glu Gln Leu Ile  Thr His Ala Ser Gly  Glu Ala Trp 
    1235                 1240                 1245             


Arg Thr  Phe Ile Tyr Gly Phe  Tyr Phe Tyr Lys Ile  Val Thr Asp 
    1250                 1255                 1260             


Lys Glu  Pro Asp Arg Val Ala  Met Gln Gln Pro Ala  Thr Thr Trp 
    1265                 1270                 1275             


His Thr  Ala Gly Val Asp Asp  Phe Ala Ser Phe Gln  Arg Lys Trp 
    1280                 1285                 1290             


Phe Glu  Val Ala Phe Val Ala  Glu Glu Leu Val His  Ser Glu Ile 
    1295                 1300                 1305             


Pro Ala  Phe Leu Leu Pro Trp  Leu Pro Ser Arg Pro  Ala Ser Tyr 
    1310                 1315                 1320             


Ala Ser  Arg His Ser Ser Phe  Ser Arg Ser Phe Gly  Gly Arg Ser 
    1325                 1330                 1335             


Gln Ala  Ala Ala Leu Leu Ala  Ala Thr Val Pro Glu  Gln Arg Thr 
    1340                 1345                 1350             


Val Thr  Leu Asp Val Asp Val  Asn Asn Arg Thr Asp  Arg Leu Glu 
    1355                 1360                 1365             


<210>  7
<211>  5551
<212>  DNA
<213>  Homo sapiens

<400>  7
ctagtaggcg cttcaggctt aggggcggaa cagcgcgggc cgcgcgggcg taggcggggt       60

atctggagga ggcgcaggga acctggagag ggtccagccc tcagtgcccc ggccagaggc      120

gggaaggggc tctagagctt cgggaggcaa gatgacttct ctgccccaag cttggaacag      180

ctaaagggaa aaacagtgca agatgagaac aacaaaggtc tacaaactcg tcatccacaa      240

gaagggcttt gggggcagtg atgatgagct agttgtgaac cccaaagtgt tccctcacat      300

caagcttgga gacattgtag agattgcaca ccccaacgat gaatacagcc ctctgctttt      360

gcaggtcaag tctcttaagg aagatttaca gaaggaaact atcagtgtgg accagactgt      420

gactcaagtg ttccggctga gaccttatca ggatgtctat gttaatgtcg tagaccctaa      480

ggatgtgacc cttgacctag tggaattaac ttttaaggat cagtatattg gccgtgggga      540

tatgtggcga ctaaagaaaa gtttggtcag cacatgtgcc tatatcaccc agaaggtgga      600

gtttgctggc atcagagcac aggctggtga actgtgggtt aagaatgaga aggtcatgtg      660

tggctacatc agtgaagata ccagggtggt gtttcgttct acgtcggcta tggtttacat      720

atttattcag atgagctgtg aaatgtggga ttttgatatt tatggggatt tgtattttga      780

gaaagctgtg aatggtttcc ttgctgatct atttaccaag tggaaggaga agaactgtag      840

tcatgaagtg acagtggtcc tgttttctag aactttctat gatgcaaaat ctgttgatga      900

atttcctgaa ataaaccgag cctcaattcg acaggatcac aaggggagat tctatgaaga      960

cttttacaaa gtggtggtgc agaatgagag aagagaagaa tggacttcac ttctcgtaac     1020

cattaaaaaa ctcttcatcc agtatccagt gttggtgcga ctggaacagg cagagggctt     1080

tcctcaagga gataattcta cctcagcaca aggaaactac ctggaggcca tcaatctgtc     1140

attcaatgtg tttgataagc actacatcaa ccgcaacttt gaccgaactg ggcagatgtc     1200

agtggtgatc acgcccgggg tgggtgtctt tgaagtggac cgcctactca tgatcctgac     1260

caagcagcgg atgatagata atggaattgg tgtggatttg gtgtgcatgg gagagcaacc     1320

gttacatgct gtcccattgt tcaagctcca taatcggagt gctccccgtg attctcgtct     1380

gggcgatgac tataatatcc ctcactggat aaaccacagt ttctacacat ccaaaagcca     1440

gctcttttgt aatagtttca ccccacgaat aaaactggca ggaaagaagc ccgcctctga     1500

gaaagcaaaa aatggccgtg atacatctct cgggagtcca aaagaatctg agaacgccct     1560

tcccatccaa gtagattatg acgcctatga cgctcaagtg ttcaggctgc ccggcccatc     1620

ccgggcccag tgcctcacca cctgcagatc tgtgcgagag cgagagagtc acagtcgaaa     1680

gagtgccagc tcctgtgatg tttcatccag cccttcccta ccaagccgca cactgcccac     1740

tgaggaagtg aggagccagg cttctgacga cagctcccta ggcaagagtg ccaacatcct     1800

gatgatccca cacccccacc tgcaccagta tgaagtcagc agctccttgg gatacaccag     1860

cactcgagat gtcctggaga acatgatgga gccaccacag cgagactcca gtgcaccagg     1920

gaggtttcac gttggcagtg cagaatccat gctgcatgtt cgacctggtg gatacacgcc     1980

ccagagagca ctgattaacc ccttcgctcc ctctcggatg cccatgaagc ttacgtccaa     2040

cagaaggcgc tggatgcaca cttttcctgt ggggccatcc ggagaagcca tccagatcca     2100

ccaccagacc cgacagaata tggcggagct acaaggcagc gggcagaggg atccaactca     2160

ctcctctgca gagctgctgg agttagcata tcatgaagct gctggaaggc acagcaattc     2220

ccgccagcct ggtgacggca tgtccttctt gaacttcagt ggaacagagg agctttctgt     2280

cggcctgctt agcaacagtg gtgcaggtat gaatcctagg acccagaata aggattctct     2340

agaggacagt gtttctacct ctccagaccc aattctgaca ctgtctgctc cccctgtagt     2400

gccaggcttc tgttgcacag ttggagtgga ctggaagtct ctcactactc cggcgtgcct     2460

cccccttacc accgactact tccctgaccg ccagggcctg cagaatgact acacagaggg     2520

ctgttatgat ctccttccag aagcagacat cgacaggagg gacgaagatg gtgtgcagat     2580

gacagcccag caggtatttg aagagtttat ttgccaacgt ctcatgcagg gctaccaaat     2640

catagtgcag cccaagacac agaaacccaa tcctgctgtc ccgcccccgc tgagcagtag     2700

cccactctat agccgaggcc ttgtgtcccg aaaccgccct gaggaggagg accagtattg     2760

gctgagtatg ggcagaacgt tccacaaagt gacgctgaag gataagatga tcacagtgac     2820

gcgatacctt cccaagtatc cttatgaatc tgcccagatc cactacacct acagcctctg     2880

tccttcccac tcagactcag agttcgtctc ctgctgggtg gaattctccc acgaacggct     2940

ggaggagtac aagtggaatt acttagatca gtatatctgt tctgccggct ctgaagactt     3000

cagcttaatt gagtccctga agttctggag gacccgcttc ctgctgctgc cagcctgtgt     3060

caccgccacc aagcgcatca cggaggggga ggcccactgc gacatctatg gggacaggcc     3120

ccgtgcagac gaggacgagt ggcaactcct ggatggtttt gtccgctttg tggagggctt     3180

gaatcgcatt cgcaggcggc atcgctcgga tcgcatgatg cggaaaggga ccgccatgaa     3240

aggcttgcag atgactgggc ccatttccac gcattctctg gagtcaactg cacccccagt     3300

ggggaagaag ggaacctcag ctctctctgc cctgttggag atggaggcca gtcagaagtg     3360

cctgggagaa cagcaggcag ctgtgcatgg tgggaagagc tccgcccagt cagccgagag     3420

cagcagcgtt gccatgactc ccacctacat ggacagccca cgaaaggacg gggccttctt     3480

tatggagttt gtccgcagcc cacgcacagc atcgtccgcc ttctaccctc aggtatctgt     3540

ggaccaaaca gccactccta tgttggacgg caccagtttg ggcatatgca caggccaatc     3600

catggacaga ggcaacagcc agacctttgg gaactcccag aacataggag aacagggcta     3660

ctcctccaca aactccagtg acagcagctc tcagcagctg gtggcaagct ccttgacctc     3720

atcctctacc ctgacagaga tcctggaagc catgaagcac ccctcgacag gagtccagct     3780

gctctctgaa cagaagggcc tctcaccgta ctgcttcatc agcgcggagg tggtacactg     3840

gttggtgaac cacgtggagg ggatccagac acaggcgatg gccattgaca tcatgcagaa     3900

aatgctggaa gagcagctca tcacacatgc atctggcgaa gcctggcgga ccttcatcta     3960

cggcttctat ttctacaaga tagtaacgga caaagagccc gaccgagtgg ccatgcagca     4020

gcccgccacc acctggcaca cagcaggagt ggacgacttc gccagcttcc agcgcaagtg     4080

gtttgaggtg gcctttgtgg cagaagagct cgtgcactct gagattcctg cctttctcct     4140

gccctggctg cctagccggc cagcctccta tgcaagtagg cacagctcct ttagccgaag     4200

ttttggagga cggagccagg cggcagcact tttagctgcc actgtcccag agcagaggac     4260

tgtgaccctg gatgttgacg tgaacaaccg cacagaccgg ctggagtggt gcagctgtta     4320

ttaccatggc aacttttctc tgaatgcagc ctttgagatc aagctgcact ggatggcggt     4380

gaccgcagca gtactcttcg agatggtcca aggttggcat cggaaagcca cctcctgtgg     4440

cttcttgtta gtcccagttt tggaggggcc ttttgcactg cccagttacc tgtatggcga     4500

cccccttcgt gcccagctct tcatcccact caacatcagc tgcttgctca aggagggcag     4560

cgagcacctg tttgatagct ttgaacccga aacgtactgg gatcgaatgc acctcttcca     4620

ggaagccatt gcacacaggt ttgggtttgt acaagataaa tattctgcct ctgcttttaa     4680

cttccctgct gagaacaagc ctcagtatat ccacgttaca ggaacagtgt ttctgcagct     4740

gccctactcc aagcgcaagt tctcagggca gcagcggcgg cggcggaact ccaccagctc     4800

caccaactag aacatgttct gcgaggagcg ggtcggctac aactgggcct acaacaccat     4860

gctcaccaaa acatggcgct ccagcgccac aggggatgaa aagtttgctg atcggctgct     4920

gaaggacttc acggacttct gcatcaaccg tgacaaccgg ctggtcacgt tctggacaag     4980

ttgcctggag aagatgcatg ccagtgcccc gtgaggccag gctgcacctg tgctggggga     5040

aggtgggtga gccactgccc tcaaacccgg ggcggaggat tccaggcagg ctctaggagt     5100

caggtgtccg tttgctgcta tcagtgagtg ggggccattg ttttttgttt gtttgtttgt     5160

ttgtttgttt gtttttggcc cccacgacaa gtcttctact ctagaagaaa gactttggaa     5220

gcagctgctg ctgctgccac cactcctgtc agcaagtgct cagagcaggt gggaggcaca     5280

gattgtccgt gggagggctc cagtgtctgg gaagagggca ggcggccccc atgaatgtcc     5340

tcggaagggg gtggctcctg gtagcatcct tttccttcac catctatggg atattagggg     5400

cagaatctgc cacttcttgc ccaggagtgt gcacagatgt aagataattt tgtgaaataa     5460

tgtaccatag actctcacca actgtatata cctgtacata tcagaagcaa ataaagagct     5520

ccacgtgcat catttctttc cccacccagt t                                    5551


<210>  8
<211>  1535
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Thr Thr Lys Val Tyr Lys Leu Val Ile His Lys Lys Gly Phe 
1               5                   10                  15      


Gly Gly Ser Asp Asp Glu Leu Val Val Asn Pro Lys Val Phe Pro His 
            20                  25                  30          


Ile Lys Leu Gly Asp Ile Val Glu Ile Ala His Pro Asn Asp Glu Tyr 
        35                  40                  45              


Ser Pro Leu Leu Leu Gln Val Lys Ser Leu Lys Glu Asp Leu Gln Lys 
    50                  55                  60                  


Glu Thr Ile Ser Val Asp Gln Thr Val Thr Gln Val Phe Arg Leu Arg 
65                  70                  75                  80  


Pro Tyr Gln Asp Val Tyr Val Asn Val Val Asp Pro Lys Asp Val Thr 
                85                  90                  95      


Leu Asp Leu Val Glu Leu Thr Phe Lys Asp Gln Tyr Ile Gly Arg Gly 
            100                 105                 110         


Asp Met Trp Arg Leu Lys Lys Ser Leu Val Ser Thr Cys Ala Tyr Ile 
        115                 120                 125             


Thr Gln Lys Val Glu Phe Ala Gly Ile Arg Ala Gln Ala Gly Glu Leu 
    130                 135                 140                 


Trp Val Lys Asn Glu Lys Val Met Cys Gly Tyr Ile Ser Glu Asp Thr 
145                 150                 155                 160 


Arg Val Val Phe Arg Ser Thr Ser Ala Met Val Tyr Ile Phe Ile Gln 
                165                 170                 175     


Met Ser Cys Glu Met Trp Asp Phe Asp Ile Tyr Gly Asp Leu Tyr Phe 
            180                 185                 190         


Glu Lys Ala Val Asn Gly Phe Leu Ala Asp Leu Phe Thr Lys Trp Lys 
        195                 200                 205             


Glu Lys Asn Cys Ser His Glu Val Thr Val Val Leu Phe Ser Arg Thr 
    210                 215                 220                 


Phe Tyr Asp Ala Lys Ser Val Asp Glu Phe Pro Glu Ile Asn Arg Ala 
225                 230                 235                 240 


Ser Ile Arg Gln Asp His Lys Gly Arg Phe Tyr Glu Asp Phe Tyr Lys 
                245                 250                 255     


Val Val Val Gln Asn Glu Arg Arg Glu Glu Trp Thr Ser Leu Leu Val 
            260                 265                 270         


Thr Ile Lys Lys Leu Phe Ile Gln Tyr Pro Val Leu Val Arg Leu Glu 
        275                 280                 285             


Gln Ala Glu Gly Phe Pro Gln Gly Asp Asn Ser Thr Ser Ala Gln Gly 
    290                 295                 300                 


Asn Tyr Leu Glu Ala Ile Asn Leu Ser Phe Asn Val Phe Asp Lys His 
305                 310                 315                 320 


Tyr Ile Asn Arg Asn Phe Asp Arg Thr Gly Gln Met Ser Val Val Ile 
                325                 330                 335     


Thr Pro Gly Val Gly Val Phe Glu Val Asp Arg Leu Leu Met Ile Leu 
            340                 345                 350         


Thr Lys Gln Arg Met Ile Asp Asn Gly Ile Gly Val Asp Leu Val Cys 
        355                 360                 365             


Met Gly Glu Gln Pro Leu His Ala Val Pro Leu Phe Lys Leu His Asn 
    370                 375                 380                 


Arg Ser Ala Pro Arg Asp Ser Arg Leu Gly Asp Asp Tyr Asn Ile Pro 
385                 390                 395                 400 


His Trp Ile Asn His Ser Phe Tyr Thr Ser Lys Ser Gln Leu Phe Cys 
                405                 410                 415     


Asn Ser Phe Thr Pro Arg Ile Lys Leu Ala Gly Lys Lys Pro Ala Ser 
            420                 425                 430         


Glu Lys Ala Lys Asn Gly Arg Asp Thr Ser Leu Gly Ser Pro Lys Glu 
        435                 440                 445             


Ser Glu Asn Ala Leu Pro Ile Gln Val Asp Tyr Asp Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Val Phe Arg Leu Pro Gly Pro Ser Arg Ala Gln Cys Leu Thr Thr 
465                 470                 475                 480 


Cys Arg Ser Val Arg Glu Arg Glu Ser His Ser Arg Lys Ser Ala Ser 
                485                 490                 495     


Ser Cys Asp Val Ser Ser Ser Pro Ser Leu Pro Ser Arg Thr Leu Pro 
            500                 505                 510         


Thr Glu Glu Val Arg Ser Gln Ala Ser Asp Asp Ser Ser Leu Gly Lys 
        515                 520                 525             


Ser Ala Asn Ile Leu Met Ile Pro His Pro His Leu His Gln Tyr Glu 
    530                 535                 540                 


Val Ser Ser Ser Leu Gly Tyr Thr Ser Thr Arg Asp Val Leu Glu Asn 
545                 550                 555                 560 


Met Met Glu Pro Pro Gln Arg Asp Ser Ser Ala Pro Gly Arg Phe His 
                565                 570                 575     


Val Gly Ser Ala Glu Ser Met Leu His Val Arg Pro Gly Gly Tyr Thr 
            580                 585                 590         


Pro Gln Arg Ala Leu Ile Asn Pro Phe Ala Pro Ser Arg Met Pro Met 
        595                 600                 605             


Lys Leu Thr Ser Asn Arg Arg Arg Trp Met His Thr Phe Pro Val Gly 
    610                 615                 620                 


Pro Ser Gly Glu Ala Ile Gln Ile His His Gln Thr Arg Gln Asn Met 
625                 630                 635                 640 


Ala Glu Leu Gln Gly Ser Gly Gln Arg Asp Pro Thr His Ser Ser Ala 
                645                 650                 655     


Glu Leu Leu Glu Leu Ala Tyr His Glu Ala Ala Gly Arg His Ser Asn 
            660                 665                 670         


Ser Arg Gln Pro Gly Asp Gly Met Ser Phe Leu Asn Phe Ser Gly Thr 
        675                 680                 685             


Glu Glu Leu Ser Val Gly Leu Leu Ser Asn Ser Gly Ala Gly Met Asn 
    690                 695                 700                 


Pro Arg Thr Gln Asn Lys Asp Ser Leu Glu Asp Ser Val Ser Thr Ser 
705                 710                 715                 720 


Pro Asp Pro Ile Leu Thr Leu Ser Ala Pro Pro Val Val Pro Gly Phe 
                725                 730                 735     


Cys Cys Thr Val Gly Val Asp Trp Lys Ser Leu Thr Thr Pro Ala Cys 
            740                 745                 750         


Leu Pro Leu Thr Thr Asp Tyr Phe Pro Asp Arg Gln Gly Leu Gln Asn 
        755                 760                 765             


Asp Tyr Thr Glu Gly Cys Tyr Asp Leu Leu Pro Glu Ala Asp Ile Asp 
    770                 775                 780                 


Arg Arg Asp Glu Asp Gly Val Gln Met Thr Ala Gln Gln Val Phe Glu 
785                 790                 795                 800 


Glu Phe Ile Cys Gln Arg Leu Met Gln Gly Tyr Gln Ile Ile Val Gln 
                805                 810                 815     


Pro Lys Thr Gln Lys Pro Asn Pro Ala Val Pro Pro Pro Leu Ser Ser 
            820                 825                 830         


Ser Pro Leu Tyr Ser Arg Gly Leu Val Ser Arg Asn Arg Pro Glu Glu 
        835                 840                 845             


Glu Asp Gln Tyr Trp Leu Ser Met Gly Arg Thr Phe His Lys Val Thr 
    850                 855                 860                 


Leu Lys Asp Lys Met Ile Thr Val Thr Arg Tyr Leu Pro Lys Tyr Pro 
865                 870                 875                 880 


Tyr Glu Ser Ala Gln Ile His Tyr Thr Tyr Ser Leu Cys Pro Ser His 
                885                 890                 895     


Ser Asp Ser Glu Phe Val Ser Cys Trp Val Glu Phe Ser His Glu Arg 
            900                 905                 910         


Leu Glu Glu Tyr Lys Trp Asn Tyr Leu Asp Gln Tyr Ile Cys Ser Ala 
        915                 920                 925             


Gly Ser Glu Asp Phe Ser Leu Ile Glu Ser Leu Lys Phe Trp Arg Thr 
    930                 935                 940                 


Arg Phe Leu Leu Leu Pro Ala Cys Val Thr Ala Thr Lys Arg Ile Thr 
945                 950                 955                 960 


Glu Gly Glu Ala His Cys Asp Ile Tyr Gly Asp Arg Pro Arg Ala Asp 
                965                 970                 975     


Glu Asp Glu Trp Gln Leu Leu Asp Gly Phe Val Arg Phe Val Glu Gly 
            980                 985                 990         


Leu Asn Arg Ile Arg Arg Arg His  Arg Ser Asp Arg Met  Met Arg Lys 
        995                 1000                 1005             


Gly Thr  Ala Met Lys Gly Leu  Gln Met Thr Gly Pro  Ile Ser Thr 
    1010                 1015                 1020             


His Ser  Leu Glu Ser Thr Ala  Pro Pro Val Gly Lys  Lys Gly Thr 
    1025                 1030                 1035             


Ser Ala  Leu Ser Ala Leu Leu  Glu Met Glu Ala Ser  Gln Lys Cys 
    1040                 1045                 1050             


Leu Gly  Glu Gln Gln Ala Ala  Val His Gly Gly Lys  Ser Ser Ala 
    1055                 1060                 1065             


Gln Ser  Ala Glu Ser Ser Ser  Val Ala Met Thr Pro  Thr Tyr Met 
    1070                 1075                 1080             


Asp Ser  Pro Arg Lys Asp Gly  Ala Phe Phe Met Glu  Phe Val Arg 
    1085                 1090                 1095             


Ser Pro  Arg Thr Ala Ser Ser  Ala Phe Tyr Pro Gln  Val Ser Val 
    1100                 1105                 1110             


Asp Gln  Thr Ala Thr Pro Met  Leu Asp Gly Thr Ser  Leu Gly Ile 
    1115                 1120                 1125             


Cys Thr  Gly Gln Ser Met Asp  Arg Gly Asn Ser Gln  Thr Phe Gly 
    1130                 1135                 1140             


Asn Ser  Gln Asn Ile Gly Glu  Gln Gly Tyr Ser Ser  Thr Asn Ser 
    1145                 1150                 1155             


Ser Asp  Ser Ser Ser Gln Gln  Leu Val Ala Ser Ser  Leu Thr Ser 
    1160                 1165                 1170             


Ser Ser  Thr Leu Thr Glu Ile  Leu Glu Ala Met Lys  His Pro Ser 
    1175                 1180                 1185             


Thr Gly  Val Gln Leu Leu Ser  Glu Gln Lys Gly Leu  Ser Pro Tyr 
    1190                 1195                 1200             


Cys Phe  Ile Ser Ala Glu Val  Val His Trp Leu Val  Asn His Val 
    1205                 1210                 1215             


Glu Gly  Ile Gln Thr Gln Ala  Met Ala Ile Asp Ile  Met Gln Lys 
    1220                 1225                 1230             


Met Leu  Glu Glu Gln Leu Ile  Thr His Ala Ser Gly  Glu Ala Trp 
    1235                 1240                 1245             


Arg Thr  Phe Ile Tyr Gly Phe  Tyr Phe Tyr Lys Ile  Val Thr Asp 
    1250                 1255                 1260             


Lys Glu  Pro Asp Arg Val Ala  Met Gln Gln Pro Ala  Thr Thr Trp 
    1265                 1270                 1275             


His Thr  Ala Gly Val Asp Asp  Phe Ala Ser Phe Gln  Arg Lys Trp 
    1280                 1285                 1290             


Phe Glu  Val Ala Phe Val Ala  Glu Glu Leu Val His  Ser Glu Ile 
    1295                 1300                 1305             


Pro Ala  Phe Leu Leu Pro Trp  Leu Pro Ser Arg Pro  Ala Ser Tyr 
    1310                 1315                 1320             


Ala Ser  Arg His Ser Ser Phe  Ser Arg Ser Phe Gly  Gly Arg Ser 
    1325                 1330                 1335             


Gln Ala  Ala Ala Leu Leu Ala  Ala Thr Val Pro Glu  Gln Arg Thr 
    1340                 1345                 1350             


Val Thr  Leu Asp Val Asp Val  Asn Asn Arg Thr Asp  Arg Leu Glu 
    1355                 1360                 1365             


Trp Cys  Ser Cys Tyr Tyr His  Gly Asn Phe Ser Leu  Asn Ala Ala 
    1370                 1375                 1380             


Phe Glu  Ile Lys Leu His Trp  Met Ala Val Thr Ala  Ala Val Leu 
    1385                 1390                 1395             


Phe Glu  Met Val Gln Gly Trp  His Arg Lys Ala Thr  Ser Cys Gly 
    1400                 1405                 1410             


Phe Leu  Leu Val Pro Val Leu  Glu Gly Pro Phe Ala  Leu Pro Ser 
    1415                 1420                 1425             


Tyr Leu  Tyr Gly Asp Pro Leu  Arg Ala Gln Leu Phe  Ile Pro Leu 
    1430                 1435                 1440             


Asn Ile  Ser Cys Leu Leu Lys  Glu Gly Ser Glu His  Leu Phe Asp 
    1445                 1450                 1455             


Ser Phe  Glu Pro Glu Thr Tyr  Trp Asp Arg Met His  Leu Phe Gln 
    1460                 1465                 1470             


Glu Ala  Ile Ala His Arg Phe  Gly Phe Val Gln Asp  Lys Tyr Ser 
    1475                 1480                 1485             


Ala Ser  Ala Phe Asn Phe Pro  Ala Glu Asn Lys Pro  Gln Tyr Ile 
    1490                 1495                 1500             


His Val  Thr Gly Thr Val Phe  Leu Gln Leu Pro Tyr  Ser Lys Arg 
    1505                 1510                 1515             


Lys Phe  Ser Gly Gln Gln Arg  Arg Arg Arg Asn Ser  Thr Ser Ser 
    1520                 1525                 1530             


Thr Asn  
    1535 


<210>  9
<211>  5551
<212>  DNA
<213>  Homo sapiens

<400>  9
ctagtaggcg cttcaggctt aggggcggaa cagcgcgggc cgcgcgggcg taggcggggt       60

atctggagga ggcgcaggga acctggagag ggtccagccc tcagtgcccc ggccagaggc      120

gggaaggggc tctagagctt cgggaggcaa gatgacttct ctgccccaag cttggaacag      180

ctaaagggaa aaacagtgca agatgagaac aacaaaggtc tacaaactcg tcatccacaa      240

gaagggcttt gggggcagtg atgatgagct agttgtgaac cccaaagtgt tccctcacat      300

caagcttgga gacattgtag agattgcaca ccccaacgat gaatacagcc ctctgctttt      360

gcaggtcaag tctcttaagg aagatttaca gaaggaaact atcagtgtgg accagactgt      420

gactcaagtg ttccggctga gaccttatca ggatgtctat gttaatgtcg tagaccctaa      480

ggatgtgacc cttgacctag tggaattaac ttttaaggat cagtatattg gccgtgggga      540

tatgtggcga ctaaagaaaa gtttggtcag cacatgtgcc tatatcaccc agaaggtgga      600

gtttgctggc atcagagcac aggctggtga actgtgggtt aagaatgaga aggtcatgtg      660

tggctacatc agtgaagata ccagggtggt gtttcgttct acgtcggcta tggtttacat      720

atttattcag atgagctgtg aaatgtggga ttttgatatt tatggggatt tgtattttga      780

gaaagctgtg aatggtttcc ttgctgatct atttaccaag tggaaggaga agaactgtag      840

tcatgaagtg acagtggtcc tgttttctag aactttctat gatgcaaaat ctgttgatga      900

atttcctgaa ataaaccgag cctcaattcg acaggatcac aaggggagat tctatgaaga      960

cttttacaaa gtggtggtgc agaatgagag aagagaagaa tggacttcac ttctcgtaac     1020

cattaaaaaa ctcttcatcc agtatccagt gttggtgcga ctggaacagg cagagggctt     1080

tcctcaagga gataattcta cctcagcaca aggaaactac ctggaggcca tcaatctgtc     1140

attcaatgtg tttgataagc actacatcaa ccgcaacttt gaccgaactg ggcagatgtc     1200

agtggtgatc acgcccgggg tgggtgtctt tgaagtggac cgcctactca tgatcctgac     1260

caagcagcgg atgatagata atggaattgg tgtggatttg gtgtgcatgg gagagcaacc     1320

gttacatgct gtcccattgt tcaagctcca taatcggagt gctccccgtg attctcgtct     1380

gggcgatgac tataatatcc ctcactggat aaaccacagt ttctacacat ccaaaagcca     1440

gctcttttgt aatagtttca ccccacgaat aaaactggca ggaaagaagc ccgcctctga     1500

gaaagcaaaa aatggccgtg atacatctct cgggagtcca aaagaatctg agaacgccct     1560

tcccatccaa gtagattatg acgcctatga cgctcaagtg ttcaggctgc ccggcccatc     1620

ccgggcccag tgcctcacca cctgcagatc tgtgcgagag cgagagagtc acagtcgaaa     1680

gagtgccagc tcctgtgatg tttcatccag cccttcccta ccaagccgca cactgcccac     1740

tgaggaagtg aggagccagg cttctgacga cagctcccta ggcaagagtg ccaacatcct     1800

gatgatccca cacccccacc tgcaccagta tgaagtcagc agctccttgg gatacaccag     1860

cactcgagat gtcctggaga acatgatgga gccaccacag cgagactcca gtgcaccagg     1920

gaggtttcac gttggcagtg cagaatccat gctgcatgtt cgacctggtg gatacacgcc     1980

ccagagagca ctgattaacc ccttcgctcc ctctcggatg cccatgaagc ttacgtccaa     2040

cagaaggcgc tggatgcaca cttttcctgt ggggccatcc ggagaagcca tccagatcca     2100

ccaccagacc cgacagaata tggcggagct acaaggcagc gggcagaggg atccaactca     2160

ctcctctgca gagctgctgg agttagcata tcatgaagct gctggaaggc acagcaattc     2220

ccgccagcct ggtgacggca tgtccttctt gaacttcagt ggaacagagg agctttctgt     2280

cggcctgctt agcaacagtg gtgcaggtat gaatcctagg acccagaata aggattctct     2340

agaggacagt gtttctacct ctccagaccc aattctgaca ctgtctgctc cccctgtagt     2400

gccaggcttc tgttgcacag ttggagtgga ctggaagtct ctcactactc cggcgtgcct     2460

cccccttacc accgactact tccctgaccg ccagggcctg cagaatgact acacagaggg     2520

ctgttatgat ctccttccag aagcagacat cgacaggagg gacgaagatg gtgtgcagat     2580

gacagcccag caggtatttg aagagtttat ttgccaacgt ctcatgcagg gctaccaaat     2640

catagtgcag cccaagacac agaaacccaa tcctgctgtc ccgcccccgc tgagcagtag     2700

cccactctat agccgaggcc ttgtgtcccg aaaccgccct gaggaggagg accagtattg     2760

gctgagtatg ggcagaacgt tccacaaagt gacgctgaag gataagatga tcacagtgac     2820

gcgatacctt cccaagtatc cttatgaatc tgcccagatc cactacacct acagcctctg     2880

tccttcccac tcagactcag agttcgtctc ctgctgggtg gaattctccc acgaacggct     2940

ggaggagtac aagtggaatt acttagatca gtatatctgt tctgccggct ctgaagactt     3000

cagcttaatt gagtccctga agttctggag gacccgcttc ctgctgctgc cagcctgtgt     3060

caccgccacc aagcgcatca cggaggggga ggcccactgc gacatctatg gggacaggcc     3120

ccgtgcagac gaggacgagt ggcaactcct ggatggtttt gtccgctttg tggagggctt     3180

gaatcgcatt cgcaggcggc atcgctcgga tcgcatgatg cggaaaggga ccgccatgaa     3240

aggcttgcag atgactgggc ccatttccac gcattctctg gagtcaactg cacccccagt     3300

ggggaagaag ggaacctcag ctctctctgc cctgttggag atggaggcca gtcagaagtg     3360

cctgggagaa cagcaggcag ctgtgcatgg tgggaagagc tccgcccagt cagccgagag     3420

cagcagcgtt gccatgactc ccacctacat ggacagccca cgaaaggacg gggccttctt     3480

tatggagttt gtccgcagcc cacgcacagc atcgtccgcc ttctaccctc aggtatctgt     3540

ggaccaaaca gccactccta tgttggacgg caccagtttg ggcatatgca caggccaatc     3600

catggacaga ggcaacagcc agacctttgg gaactcccag aacataggag aacagggcta     3660

ctcctccaca aactccagtg acagcagctc tcagcagctg gtggcaagct ccttgacctc     3720

atcctctacc ctgacagaga tcctggaagc catgaagcac ccctcgacag gagtccagct     3780

gctctctgaa cagaagggcc tctcaccgta ctgcttcatc agcgcggagg tggtacactg     3840

gttggtgaac cacgtggagg ggatccagac acaggcgatg gccattgaca tcatgcagaa     3900

aatgctggaa gagcagctca tcacacatgc atctggcgaa gcctggcgga ccttcatcta     3960

cggcttctat ttctacaaga tagtaacgga caaagagccc gaccgagtgg ccatgcagca     4020

gcccgccacc acctggcaca cagcaggagt ggacgacttc gccagcttcc agcgcaagtg     4080

gtttgaggtg gcctttgtgg cagaagagct cgtgcactct gagattcctg cctttctcct     4140

gccctggctg cctagccggc cagcctccta tgcaagtagg cacagctcct ttagccgaag     4200

ttttggagga cggagccagg cggcagcact tttagctgcc actgtcccag agcagaggac     4260

tgtgaccctg gatgttgacg tgaacaaccg cacagaccgg ctggagtggt gcagctgtta     4320

ttaccatggc aacttttctc tgaatgcagc ctttgagatc aagctgcact ggatggcggt     4380

gaccgcagca gtactcttcg agatggtcca aggttggcat cggaaagcca cctcctgtgg     4440

cttcttgtta gtcccagttt tggaggggcc ttttgcactg cccagttacc tgtatggcga     4500

cccccttcgt gcccagctct tcatcccact caacatcagc tgcttgctca aggagggcag     4560

cgagcacctg tttgatagct ttgaacccga aacgtactag gatcgaatgc acctcttcca     4620

ggaagccatt gcacacaggt ttgggtttgt acaagataaa tattctgcct ctgcttttaa     4680

cttccctgct gagaacaagc ctcagtatat ccacgttaca ggaacagtgt ttctgcagct     4740

gccctactcc aagcgcaagt tctcagggca gcagcggcgg cggcggaact ccaccagctc     4800

caccaaccag aacatgttct gcgaggagcg ggtcggctac aactgggcct acaacaccat     4860

gctcaccaaa acatggcgct ccagcgccac aggggatgaa aagtttgctg atcggctgct     4920

gaaggacttc acggacttct gcatcaaccg tgacaaccgg ctggtcacgt tctggacaag     4980

ttgcctggag aagatgcatg ccagtgcccc gtgaggccag gctgcacctg tgctggggga     5040

aggtgggtga gccactgccc tcaaacccgg ggcggaggat tccaggcagg ctctaggagt     5100

caggtgtccg tttgctgcta tcagtgagtg ggggccattg ttttttgttt gtttgtttgt     5160

ttgtttgttt gtttttggcc cccacgacaa gtcttctact ctagaagaaa gactttggaa     5220

gcagctgctg ctgctgccac cactcctgtc agcaagtgct cagagcaggt gggaggcaca     5280

gattgtccgt gggagggctc cagtgtctgg gaagagggca ggcggccccc atgaatgtcc     5340

tcggaagggg gtggctcctg gtagcatcct tttccttcac catctatggg atattagggg     5400

cagaatctgc cacttcttgc ccaggagtgt gcacagatgt aagataattt tgtgaaataa     5460

tgtaccatag actctcacca actgtatata cctgtacata tcagaagcaa ataaagagct     5520

ccacgtgcat catttctttc cccacccagt t                                    5551


<210>  10
<211>  1465
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Arg Thr Thr Lys Val Tyr Lys Leu Val Ile His Lys Lys Gly Phe 
1               5                   10                  15      


Gly Gly Ser Asp Asp Glu Leu Val Val Asn Pro Lys Val Phe Pro His 
            20                  25                  30          


Ile Lys Leu Gly Asp Ile Val Glu Ile Ala His Pro Asn Asp Glu Tyr 
        35                  40                  45              


Ser Pro Leu Leu Leu Gln Val Lys Ser Leu Lys Glu Asp Leu Gln Lys 
    50                  55                  60                  


Glu Thr Ile Ser Val Asp Gln Thr Val Thr Gln Val Phe Arg Leu Arg 
65                  70                  75                  80  


Pro Tyr Gln Asp Val Tyr Val Asn Val Val Asp Pro Lys Asp Val Thr 
                85                  90                  95      


Leu Asp Leu Val Glu Leu Thr Phe Lys Asp Gln Tyr Ile Gly Arg Gly 
            100                 105                 110         


Asp Met Trp Arg Leu Lys Lys Ser Leu Val Ser Thr Cys Ala Tyr Ile 
        115                 120                 125             


Thr Gln Lys Val Glu Phe Ala Gly Ile Arg Ala Gln Ala Gly Glu Leu 
    130                 135                 140                 


Trp Val Lys Asn Glu Lys Val Met Cys Gly Tyr Ile Ser Glu Asp Thr 
145                 150                 155                 160 


Arg Val Val Phe Arg Ser Thr Ser Ala Met Val Tyr Ile Phe Ile Gln 
                165                 170                 175     


Met Ser Cys Glu Met Trp Asp Phe Asp Ile Tyr Gly Asp Leu Tyr Phe 
            180                 185                 190         


Glu Lys Ala Val Asn Gly Phe Leu Ala Asp Leu Phe Thr Lys Trp Lys 
        195                 200                 205             


Glu Lys Asn Cys Ser His Glu Val Thr Val Val Leu Phe Ser Arg Thr 
    210                 215                 220                 


Phe Tyr Asp Ala Lys Ser Val Asp Glu Phe Pro Glu Ile Asn Arg Ala 
225                 230                 235                 240 


Ser Ile Arg Gln Asp His Lys Gly Arg Phe Tyr Glu Asp Phe Tyr Lys 
                245                 250                 255     


Val Val Val Gln Asn Glu Arg Arg Glu Glu Trp Thr Ser Leu Leu Val 
            260                 265                 270         


Thr Ile Lys Lys Leu Phe Ile Gln Tyr Pro Val Leu Val Arg Leu Glu 
        275                 280                 285             


Gln Ala Glu Gly Phe Pro Gln Gly Asp Asn Ser Thr Ser Ala Gln Gly 
    290                 295                 300                 


Asn Tyr Leu Glu Ala Ile Asn Leu Ser Phe Asn Val Phe Asp Lys His 
305                 310                 315                 320 


Tyr Ile Asn Arg Asn Phe Asp Arg Thr Gly Gln Met Ser Val Val Ile 
                325                 330                 335     


Thr Pro Gly Val Gly Val Phe Glu Val Asp Arg Leu Leu Met Ile Leu 
            340                 345                 350         


Thr Lys Gln Arg Met Ile Asp Asn Gly Ile Gly Val Asp Leu Val Cys 
        355                 360                 365             


Met Gly Glu Gln Pro Leu His Ala Val Pro Leu Phe Lys Leu His Asn 
    370                 375                 380                 


Arg Ser Ala Pro Arg Asp Ser Arg Leu Gly Asp Asp Tyr Asn Ile Pro 
385                 390                 395                 400 


His Trp Ile Asn His Ser Phe Tyr Thr Ser Lys Ser Gln Leu Phe Cys 
                405                 410                 415     


Asn Ser Phe Thr Pro Arg Ile Lys Leu Ala Gly Lys Lys Pro Ala Ser 
            420                 425                 430         


Glu Lys Ala Lys Asn Gly Arg Asp Thr Ser Leu Gly Ser Pro Lys Glu 
        435                 440                 445             


Ser Glu Asn Ala Leu Pro Ile Gln Val Asp Tyr Asp Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Val Phe Arg Leu Pro Gly Pro Ser Arg Ala Gln Cys Leu Thr Thr 
465                 470                 475                 480 


Cys Arg Ser Val Arg Glu Arg Glu Ser His Ser Arg Lys Ser Ala Ser 
                485                 490                 495     


Ser Cys Asp Val Ser Ser Ser Pro Ser Leu Pro Ser Arg Thr Leu Pro 
            500                 505                 510         


Thr Glu Glu Val Arg Ser Gln Ala Ser Asp Asp Ser Ser Leu Gly Lys 
        515                 520                 525             


Ser Ala Asn Ile Leu Met Ile Pro His Pro His Leu His Gln Tyr Glu 
    530                 535                 540                 


Val Ser Ser Ser Leu Gly Tyr Thr Ser Thr Arg Asp Val Leu Glu Asn 
545                 550                 555                 560 


Met Met Glu Pro Pro Gln Arg Asp Ser Ser Ala Pro Gly Arg Phe His 
                565                 570                 575     


Val Gly Ser Ala Glu Ser Met Leu His Val Arg Pro Gly Gly Tyr Thr 
            580                 585                 590         


Pro Gln Arg Ala Leu Ile Asn Pro Phe Ala Pro Ser Arg Met Pro Met 
        595                 600                 605             


Lys Leu Thr Ser Asn Arg Arg Arg Trp Met His Thr Phe Pro Val Gly 
    610                 615                 620                 


Pro Ser Gly Glu Ala Ile Gln Ile His His Gln Thr Arg Gln Asn Met 
625                 630                 635                 640 


Ala Glu Leu Gln Gly Ser Gly Gln Arg Asp Pro Thr His Ser Ser Ala 
                645                 650                 655     


Glu Leu Leu Glu Leu Ala Tyr His Glu Ala Ala Gly Arg His Ser Asn 
            660                 665                 670         


Ser Arg Gln Pro Gly Asp Gly Met Ser Phe Leu Asn Phe Ser Gly Thr 
        675                 680                 685             


Glu Glu Leu Ser Val Gly Leu Leu Ser Asn Ser Gly Ala Gly Met Asn 
    690                 695                 700                 


Pro Arg Thr Gln Asn Lys Asp Ser Leu Glu Asp Ser Val Ser Thr Ser 
705                 710                 715                 720 


Pro Asp Pro Ile Leu Thr Leu Ser Ala Pro Pro Val Val Pro Gly Phe 
                725                 730                 735     


Cys Cys Thr Val Gly Val Asp Trp Lys Ser Leu Thr Thr Pro Ala Cys 
            740                 745                 750         


Leu Pro Leu Thr Thr Asp Tyr Phe Pro Asp Arg Gln Gly Leu Gln Asn 
        755                 760                 765             


Asp Tyr Thr Glu Gly Cys Tyr Asp Leu Leu Pro Glu Ala Asp Ile Asp 
    770                 775                 780                 


Arg Arg Asp Glu Asp Gly Val Gln Met Thr Ala Gln Gln Val Phe Glu 
785                 790                 795                 800 


Glu Phe Ile Cys Gln Arg Leu Met Gln Gly Tyr Gln Ile Ile Val Gln 
                805                 810                 815     


Pro Lys Thr Gln Lys Pro Asn Pro Ala Val Pro Pro Pro Leu Ser Ser 
            820                 825                 830         


Ser Pro Leu Tyr Ser Arg Gly Leu Val Ser Arg Asn Arg Pro Glu Glu 
        835                 840                 845             


Glu Asp Gln Tyr Trp Leu Ser Met Gly Arg Thr Phe His Lys Val Thr 
    850                 855                 860                 


Leu Lys Asp Lys Met Ile Thr Val Thr Arg Tyr Leu Pro Lys Tyr Pro 
865                 870                 875                 880 


Tyr Glu Ser Ala Gln Ile His Tyr Thr Tyr Ser Leu Cys Pro Ser His 
                885                 890                 895     


Ser Asp Ser Glu Phe Val Ser Cys Trp Val Glu Phe Ser His Glu Arg 
            900                 905                 910         


Leu Glu Glu Tyr Lys Trp Asn Tyr Leu Asp Gln Tyr Ile Cys Ser Ala 
        915                 920                 925             


Gly Ser Glu Asp Phe Ser Leu Ile Glu Ser Leu Lys Phe Trp Arg Thr 
    930                 935                 940                 


Arg Phe Leu Leu Leu Pro Ala Cys Val Thr Ala Thr Lys Arg Ile Thr 
945                 950                 955                 960 


Glu Gly Glu Ala His Cys Asp Ile Tyr Gly Asp Arg Pro Arg Ala Asp 
                965                 970                 975     


Glu Asp Glu Trp Gln Leu Leu Asp Gly Phe Val Arg Phe Val Glu Gly 
            980                 985                 990         


Leu Asn Arg Ile Arg Arg Arg His  Arg Ser Asp Arg Met  Met Arg Lys 
        995                 1000                 1005             


Gly Thr  Ala Met Lys Gly Leu  Gln Met Thr Gly Pro  Ile Ser Thr 
    1010                 1015                 1020             


His Ser  Leu Glu Ser Thr Ala  Pro Pro Val Gly Lys  Lys Gly Thr 
    1025                 1030                 1035             


Ser Ala  Leu Ser Ala Leu Leu  Glu Met Glu Ala Ser  Gln Lys Cys 
    1040                 1045                 1050             


Leu Gly  Glu Gln Gln Ala Ala  Val His Gly Gly Lys  Ser Ser Ala 
    1055                 1060                 1065             


Gln Ser  Ala Glu Ser Ser Ser  Val Ala Met Thr Pro  Thr Tyr Met 
    1070                 1075                 1080             


Asp Ser  Pro Arg Lys Asp Gly  Ala Phe Phe Met Glu  Phe Val Arg 
    1085                 1090                 1095             


Ser Pro  Arg Thr Ala Ser Ser  Ala Phe Tyr Pro Gln  Val Ser Val 
    1100                 1105                 1110             


Asp Gln  Thr Ala Thr Pro Met  Leu Asp Gly Thr Ser  Leu Gly Ile 
    1115                 1120                 1125             


Cys Thr  Gly Gln Ser Met Asp  Arg Gly Asn Ser Gln  Thr Phe Gly 
    1130                 1135                 1140             


Asn Ser  Gln Asn Ile Gly Glu  Gln Gly Tyr Ser Ser  Thr Asn Ser 
    1145                 1150                 1155             


Ser Asp  Ser Ser Ser Gln Gln  Leu Val Ala Ser Ser  Leu Thr Ser 
    1160                 1165                 1170             


Ser Ser  Thr Leu Thr Glu Ile  Leu Glu Ala Met Lys  His Pro Ser 
    1175                 1180                 1185             


Thr Gly  Val Gln Leu Leu Ser  Glu Gln Lys Gly Leu  Ser Pro Tyr 
    1190                 1195                 1200             


Cys Phe  Ile Ser Ala Glu Val  Val His Trp Leu Val  Asn His Val 
    1205                 1210                 1215             


Glu Gly  Ile Gln Thr Gln Ala  Met Ala Ile Asp Ile  Met Gln Lys 
    1220                 1225                 1230             


Met Leu  Glu Glu Gln Leu Ile  Thr His Ala Ser Gly  Glu Ala Trp 
    1235                 1240                 1245             


Arg Thr  Phe Ile Tyr Gly Phe  Tyr Phe Tyr Lys Ile  Val Thr Asp 
    1250                 1255                 1260             


Lys Glu  Pro Asp Arg Val Ala  Met Gln Gln Pro Ala  Thr Thr Trp 
    1265                 1270                 1275             


His Thr  Ala Gly Val Asp Asp  Phe Ala Ser Phe Gln  Arg Lys Trp 
    1280                 1285                 1290             


Phe Glu  Val Ala Phe Val Ala  Glu Glu Leu Val His  Ser Glu Ile 
    1295                 1300                 1305             


Pro Ala  Phe Leu Leu Pro Trp  Leu Pro Ser Arg Pro  Ala Ser Tyr 
    1310                 1315                 1320             


Ala Ser  Arg His Ser Ser Phe  Ser Arg Ser Phe Gly  Gly Arg Ser 
    1325                 1330                 1335             


Gln Ala  Ala Ala Leu Leu Ala  Ala Thr Val Pro Glu  Gln Arg Thr 
    1340                 1345                 1350             


Val Thr  Leu Asp Val Asp Val  Asn Asn Arg Thr Asp  Arg Leu Glu 
    1355                 1360                 1365             


Trp Cys  Ser Cys Tyr Tyr His  Gly Asn Phe Ser Leu  Asn Ala Ala 
    1370                 1375                 1380             


Phe Glu  Ile Lys Leu His Trp  Met Ala Val Thr Ala  Ala Val Leu 
    1385                 1390                 1395             


Phe Glu  Met Val Gln Gly Trp  His Arg Lys Ala Thr  Ser Cys Gly 
    1400                 1405                 1410             


Phe Leu  Leu Val Pro Val Leu  Glu Gly Pro Phe Ala  Leu Pro Ser 
    1415                 1420                 1425             


Tyr Leu  Tyr Gly Asp Pro Leu  Arg Ala Gln Leu Phe  Ile Pro Leu 
    1430                 1435                 1440             


Asn Ile  Ser Cys Leu Leu Lys  Glu Gly Ser Glu His  Leu Phe Asp 
    1445                 1450                 1455             


Ser Phe  Glu Pro Glu Thr Tyr  
    1460                 1465 


<210>  11
<211>  5551
<212>  DNA
<213>  Homo sapiens

<400>  11
ctagtaggcg cttcaggctt aggggcggaa cagcgcgggc cgcgcgggcg taggcggggt       60

atctggagga ggcgcaggga acctggagag ggtccagccc tcagtgcccc ggccagaggc      120

gggaaggggc tctagagctt cgggaggcaa gatgacttct ctgccccaag cttggaacag      180

ctaaagggaa aaacagtgca agatgagaac aacaaaggtc tacaaactcg tcatccacaa      240

gaagggcttt gggggcagtg atgatgagct agttgtgaac cccaaagtgt tccctcacat      300

caagcttgga gacattgtag agattgcaca ccccaacgat gaatacagcc ctctgctttt      360

gcaggtcaag tctcttaagg aagatttaca gaaggaaact atcagtgtgg accagactgt      420

gactcaagtg ttccggctga gaccttatca ggatgtctat gttaatgtcg tagaccctaa      480

ggatgtgacc cttgacctag tggaattaac ttttaaggat cagtatattg gccgtgggga      540

tatgtggcga ctaaagaaaa gtttggtcag cacatgtgcc tatatcaccc agaaggtgga      600

gtttgctggc atcagagcac aggctggtga actgtgggtt aagaatgaga aggtcatgtg      660

tggctacatc agtgaagata ccagggtggt gtttcgttct acgtcggcta tggtttacat      720

atttattcag atgagctgtg aaatgtggga ttttgatatt tatggggatt tgtattttga      780

gaaagctgtg aatggtttcc ttgctgatct atttaccaag tggaaggaga agaactgtag      840

tcatgaagtg acagtggtcc tgttttctag aactttctat gatgcaaaat ctgttgatga      900

atttcctgaa ataaaccgag cctcaattcg acaggatcac aaggggagat tctatgaaga      960

cttttacaaa gtggtggtgc agaatgagag aagagaagaa tggacttcac ttctcgtaac     1020

cattaaaaaa ctcttcatcc agtatccagt gttggtgcga ctggaacagg cagagggctt     1080

tcctcaagga gataattcta cctcagcaca aggaaactac ctggaggcca tcaatctgtc     1140

attcaatgtg tttgataagc actacatcaa ccgcaacttt gaccgaactg ggcagatgtc     1200

agtggtgatc acgcccgggg tgggtgtctt tgaagtggac cgcctactca tgatcctgac     1260

caagcagcgg atgatagata atggaattgg tgtggatttg gtgtgcatgg gagagcaacc     1320

gttacatgct gtcccattgt tcaagctcca taatcggagt gctccccgtg attctcgtct     1380

gggcgatgac tataatatcc ctcactggat aaaccacagt ttctacacat ccaaaagcca     1440

gctcttttgt aatagtttca ccccacgaat aaaactggca ggaaagaagc ccgcctctga     1500

gaaagcaaaa aatggccgtg atacatctct cgggagtcca aaagaatctg agaacgccct     1560

tcccatccaa gtagattatg acgcctatga cgctcaagtg ttcaggctgc ccggcccatc     1620

ccgggcccag tgcctcacca cctgcagatc tgtgcgagag tgagagagtc acagtcgaaa     1680

gagtgccagc tcctgtgatg tttcatccag cccttcccta ccaagccgca cactgcccac     1740

tgaggaagtg aggagccagg cttctgacga cagctcccta ggcaagagtg ccaacatcct     1800

gatgatccca cacccccacc tgcaccagta tgaagtcagc agctccttgg gatacaccag     1860

cactcgagat gtcctggaga acatgatgga gccaccacag cgagactcca gtgcaccagg     1920

gaggtttcac gttggcagtg cagaatccat gctgcatgtt cgacctggtg gatacacgcc     1980

ccagagagca ctgattaacc ccttcgctcc ctctcggatg cccatgaagc ttacgtccaa     2040

cagaaggcgc tggatgcaca cttttcctgt ggggccatcc ggagaagcca tccagatcca     2100

ccaccagacc cgacagaata tggcggagct acaaggcagc gggcagaggg atccaactca     2160

ctcctctgca gagctgctgg agttagcata tcatgaagct gctggaaggc acagcaattc     2220

ccgccagcct ggtgacggca tgtccttctt gaacttcagt ggaacagagg agctttctgt     2280

cggcctgctt agcaacagtg gtgcaggtat gaatcctagg acccagaata aggattctct     2340

agaggacagt gtttctacct ctccagaccc aattctgaca ctgtctgctc cccctgtagt     2400

gccaggcttc tgttgcacag ttggagtgga ctggaagtct ctcactactc cggcgtgcct     2460

cccccttacc accgactact tccctgaccg ccagggcctg cagaatgact acacagaggg     2520

ctgttatgat ctccttccag aagcagacat cgacaggagg gacgaagatg gtgtgcagat     2580

gacagcccag caggtatttg aagagtttat ttgccaacgt ctcatgcagg gctaccaaat     2640

catagtgcag cccaagacac agaaacccaa tcctgctgtc ccgcccccgc tgagcagtag     2700

cccactctat agccgaggcc ttgtgtcccg aaaccgccct gaggaggagg accagtattg     2760

gctgagtatg ggcagaacgt tccacaaagt gacgctgaag gataagatga tcacagtgac     2820

gcgatacctt cccaagtatc cttatgaatc tgcccagatc cactacacct acagcctctg     2880

tccttcccac tcagactcag agttcgtctc ctgctgggtg gaattctccc acgaacggct     2940

ggaggagtac aagtggaatt acttagatca gtatatctgt tctgccggct ctgaagactt     3000

cagcttaatt gagtccctga agttctggag gacccgcttc ctgctgctgc cagcctgtgt     3060

caccgccacc aagcgcatca cggaggggga ggcccactgc gacatctatg gggacaggcc     3120

ccgtgcagac gaggacgagt ggcaactcct ggatggtttt gtccgctttg tggagggctt     3180

gaatcgcatt cgcaggcggc atcgctcgga tcgcatgatg cggaaaggga ccgccatgaa     3240

aggcttgcag atgactgggc ccatttccac gcattctctg gagtcaactg cacccccagt     3300

ggggaagaag ggaacctcag ctctctctgc cctgttggag atggaggcca gtcagaagtg     3360

cctgggagaa cagcaggcag ctgtgcatgg tgggaagagc tccgcccagt cagccgagag     3420

cagcagcgtt gccatgactc ccacctacat ggacagccca cgaaaggacg gggccttctt     3480

tatggagttt gtccgcagcc cacgcacagc atcgtccgcc ttctaccctc aggtatctgt     3540

ggaccaaaca gccactccta tgttggacgg caccagtttg ggcatatgca caggccaatc     3600

catggacaga ggcaacagcc agacctttgg gaactcccag aacataggag aacagggcta     3660

ctcctccaca aactccagtg acagcagctc tcagcagctg gtggcaagct ccttgacctc     3720

atcctctacc ctgacagaga tcctggaagc catgaagcac ccctcgacag gagtccagct     3780

gctctctgaa cagaagggcc tctcaccgta ctgcttcatc agcgcggagg tggtacactg     3840

gttggtgaac cacgtggagg ggatccagac acaggcgatg gccattgaca tcatgcagaa     3900

aatgctggaa gagcagctca tcacacatgc atctggcgaa gcctggcgga ccttcatcta     3960

cggcttctat ttctacaaga tagtaacgga caaagagccc gaccgagtgg ccatgcagca     4020

gcccgccacc acctggcaca cagcaggagt ggacgacttc gccagcttcc agcgcaagtg     4080

gtttgaggtg gcctttgtgg cagaagagct cgtgcactct gagattcctg cctttctcct     4140

gccctggctg cctagccggc cagcctccta tgcaagtagg cacagctcct ttagccgaag     4200

ttttggagga cggagccagg cggcagcact tttagctgcc actgtcccag agcagaggac     4260

tgtgaccctg gatgttgacg tgaacaaccg cacagaccgg ctggagtggt gcagctgtta     4320

ttaccatggc aacttttctc tgaatgcagc ctttgagatc aagctgcact ggatggcggt     4380

gaccgcagca gtactcttcg agatggtcca aggttggcat cggaaagcca cctcctgtgg     4440

cttcttgtta gtcccagttt tggaggggcc ttttgcactg cccagttacc tgtatggcga     4500

cccccttcgt gcccagctct tcatcccact caacatcagc tgcttgctca aggagggcag     4560

cgagcacctg tttgatagct ttgaacccga aacgtactgg gatcgaatgc acctcttcca     4620

ggaagccatt gcacacaggt ttgggtttgt acaagataaa tattctgcct ctgcttttaa     4680

cttccctgct gagaacaagc ctcagtatat ccacgttaca ggaacagtgt ttctgcagct     4740

gccctactcc aagcgcaagt tctcagggca gcagcggcgg cggcggaact ccaccagctc     4800

caccaaccag aacatgttct gcgaggagcg ggtcggctac aactgggcct acaacaccat     4860

gctcaccaaa acatggcgct ccagcgccac aggggatgaa aagtttgctg atcggctgct     4920

gaaggacttc acggacttct gcatcaaccg tgacaaccgg ctggtcacgt tctggacaag     4980

ttgcctggag aagatgcatg ccagtgcccc gtgaggccag gctgcacctg tgctggggga     5040

aggtgggtga gccactgccc tcaaacccgg ggcggaggat tccaggcagg ctctaggagt     5100

caggtgtccg tttgctgcta tcagtgagtg ggggccattg ttttttgttt gtttgtttgt     5160

ttgtttgttt gtttttggcc cccacgacaa gtcttctact ctagaagaaa gactttggaa     5220

gcagctgctg ctgctgccac cactcctgtc agcaagtgct cagagcaggt gggaggcaca     5280

gattgtccgt gggagggctc cagtgtctgg gaagagggca ggcggccccc atgaatgtcc     5340

tcggaagggg gtggctcctg gtagcatcct tttccttcac catctatggg atattagggg     5400

cagaatctgc cacttcttgc ccaggagtgt gcacagatgt aagataattt tgtgaaataa     5460

tgtaccatag actctcacca actgtatata cctgtacata tcagaagcaa ataaagagct     5520

ccacgtgcat catttctttc cccacccagt t                                    5551


<210>  12
<211>  486
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Arg Thr Thr Lys Val Tyr Lys Leu Val Ile His Lys Lys Gly Phe 
1               5                   10                  15      


Gly Gly Ser Asp Asp Glu Leu Val Val Asn Pro Lys Val Phe Pro His 
            20                  25                  30          


Ile Lys Leu Gly Asp Ile Val Glu Ile Ala His Pro Asn Asp Glu Tyr 
        35                  40                  45              


Ser Pro Leu Leu Leu Gln Val Lys Ser Leu Lys Glu Asp Leu Gln Lys 
    50                  55                  60                  


Glu Thr Ile Ser Val Asp Gln Thr Val Thr Gln Val Phe Arg Leu Arg 
65                  70                  75                  80  


Pro Tyr Gln Asp Val Tyr Val Asn Val Val Asp Pro Lys Asp Val Thr 
                85                  90                  95      


Leu Asp Leu Val Glu Leu Thr Phe Lys Asp Gln Tyr Ile Gly Arg Gly 
            100                 105                 110         


Asp Met Trp Arg Leu Lys Lys Ser Leu Val Ser Thr Cys Ala Tyr Ile 
        115                 120                 125             


Thr Gln Lys Val Glu Phe Ala Gly Ile Arg Ala Gln Ala Gly Glu Leu 
    130                 135                 140                 


Trp Val Lys Asn Glu Lys Val Met Cys Gly Tyr Ile Ser Glu Asp Thr 
145                 150                 155                 160 


Arg Val Val Phe Arg Ser Thr Ser Ala Met Val Tyr Ile Phe Ile Gln 
                165                 170                 175     


Met Ser Cys Glu Met Trp Asp Phe Asp Ile Tyr Gly Asp Leu Tyr Phe 
            180                 185                 190         


Glu Lys Ala Val Asn Gly Phe Leu Ala Asp Leu Phe Thr Lys Trp Lys 
        195                 200                 205             


Glu Lys Asn Cys Ser His Glu Val Thr Val Val Leu Phe Ser Arg Thr 
    210                 215                 220                 


Phe Tyr Asp Ala Lys Ser Val Asp Glu Phe Pro Glu Ile Asn Arg Ala 
225                 230                 235                 240 


Ser Ile Arg Gln Asp His Lys Gly Arg Phe Tyr Glu Asp Phe Tyr Lys 
                245                 250                 255     


Val Val Val Gln Asn Glu Arg Arg Glu Glu Trp Thr Ser Leu Leu Val 
            260                 265                 270         


Thr Ile Lys Lys Leu Phe Ile Gln Tyr Pro Val Leu Val Arg Leu Glu 
        275                 280                 285             


Gln Ala Glu Gly Phe Pro Gln Gly Asp Asn Ser Thr Ser Ala Gln Gly 
    290                 295                 300                 


Asn Tyr Leu Glu Ala Ile Asn Leu Ser Phe Asn Val Phe Asp Lys His 
305                 310                 315                 320 


Tyr Ile Asn Arg Asn Phe Asp Arg Thr Gly Gln Met Ser Val Val Ile 
                325                 330                 335     


Thr Pro Gly Val Gly Val Phe Glu Val Asp Arg Leu Leu Met Ile Leu 
            340                 345                 350         


Thr Lys Gln Arg Met Ile Asp Asn Gly Ile Gly Val Asp Leu Val Cys 
        355                 360                 365             


Met Gly Glu Gln Pro Leu His Ala Val Pro Leu Phe Lys Leu His Asn 
    370                 375                 380                 


Arg Ser Ala Pro Arg Asp Ser Arg Leu Gly Asp Asp Tyr Asn Ile Pro 
385                 390                 395                 400 


His Trp Ile Asn His Ser Phe Tyr Thr Ser Lys Ser Gln Leu Phe Cys 
                405                 410                 415     


Asn Ser Phe Thr Pro Arg Ile Lys Leu Ala Gly Lys Lys Pro Ala Ser 
            420                 425                 430         


Glu Lys Ala Lys Asn Gly Arg Asp Thr Ser Leu Gly Ser Pro Lys Glu 
        435                 440                 445             


Ser Glu Asn Ala Leu Pro Ile Gln Val Asp Tyr Asp Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Val Phe Arg Leu Pro Gly Pro Ser Arg Ala Gln Cys Leu Thr Thr 
465                 470                 475                 480 


Cys Arg Ser Val Arg Glu 
                485     


<210>  13
<211>  5551
<212>  DNA
<213>  Homo sapiens

<400>  13
ctagtaggcg cttcaggctt aggggcggaa cagcgcgggc cgcgcgggcg taggcggggt       60

atctggagga ggcgcaggga acctggagag ggtccagccc tcagtgcccc ggccagaggc      120

gggaaggggc tctagagctt cgggaggcaa gatgacttct ctgccccaag cttggaacag      180

ctaaagggaa aaacagtgca agatgagaac aacaaaggtc tacaaactcg tcatccacaa      240

gaagggcttt gggggcagtg atgatgagct agttgtgaac cccaaagtgt tccctcacat      300

caagcttgga gacattgtag agattgcaca ccccaacgat gaatacagcc ctctgctttt      360

gcaggtcaag tctcttaagg aagatttaca gaaggaaact atcagtgtgg accagactgt      420

gactcaagtg ttccggctga gaccttatca ggatgtctat gttaatgtcg tagaccctaa      480

ggatgtgacc cttgacctag tggaattaac ttttaaggat cagtatattg gccgtgggga      540

tatgtggcga ctaaagaaaa gtttggtcag cacatgtgcc tatatcaccc agaaggtgga      600

gtttgctggc atcagagcac aggctggtga actgtgggtt aagaatgaga aggtcatgtg      660

tggctacatc agtgaagata ccagggtggt gtttcgttct acgtcggcta tggtttacat      720

atttattcag atgagctgtg aaatgtggga ttttgatatt tatggggatt tgtattttga      780

gaaagctgtg aatggtttcc ttgctgatct atttaccaag tggaaggaga agaactgtag      840

tcatgaagtg acagtggtcc tgttttctag aactttctat gatgcaaaat ctgttgatga      900

atttcctgaa ataaaccgag cctcaattcg acaggatcac aaggggagat tctatgaaga      960

cttttacaaa gtggtggtgc agaatgagag aagagaagaa tggacttcac ttctcgtaac     1020

cattaaaaaa ctcttcatcc agtatccagt gttggtgcga ctggaacagg cagagggctt     1080

tcctcaagga gataattcta cctcagcaca aggaaactac ctggaggcca tcaatctgtc     1140

attcaatgtg tttgataagc actacatcaa ccgcaacttt gaccgaactg ggcagatgtc     1200

agtggtgatc acgcccgggg tgggtgtctt tgaagtggac cgcctactca tgatcctgac     1260

caagcagcgg atgatagata atggaattgg tgtggatttg gtgtgcatgg gagagcaacc     1320

gttacatgct gtcccattgt tcaagctcca taatcggagt gctccccgtg attctcgtct     1380

gggcgatgac tataatatcc ctcactggat aaaccacagt ttctacacat ccaaaagcca     1440

gctcttttgt aatagtttca ccccacgaat aaaactggca ggaaagaagc ccgcctctga     1500

gaaagcaaaa aatggccgtg atacatctct cgggagtcca aaagaatctg agaacgccct     1560

tcccatccaa gtagattatg acgcctatga cgctcaagtg ttcaggctgc ccggcccatc     1620

ccgggcccag tgcctcacca cctgcagatc tgtgcgagag cgagagagtc acagtcgaaa     1680

gagtgccagc tcctgtgatg tttcatccag cccttcccta ccaagccgca cactgcccac     1740

tgaggaagtg aggagccagg cttctgacga cagctcccta ggcaagagtg ccaacatcct     1800

gatgatccca cacccccacc tgcaccagta tgaagtcagc agctccttgg gatacaccag     1860

cactcgagat gtcctggaga acatgatgga gccaccacag cgagactcca gtgcaccagg     1920

gaggtttcac gttggcagtg cagaatccat gctgcatgtt cgacctggtg gatacacgcc     1980

ccagagagca ctgattaacc ccttcgctcc ctctcggatg cccatgaagc ttacgtccaa     2040

cagaaggcgc tggatgcaca cttttcctgt ggggccatcc ggagaagcca tccagatcca     2100

ccaccagacc cgacagaata tggcggagct acaaggcagc gggcagaggg atccaactca     2160

ctcctctgca gagctgctgg agttagcata tcatgaagct gctggaaggc acagcaattc     2220

ccgccagcct ggtgacggca tgtccttctt gaacttcagt ggaacagagg agctttctgt     2280

cggcctgctt agcaacagtg gtgcaggtat gaatcctagg acccagaata aggattctct     2340

agaggacagt gtttctacct ctccagaccc aattctgaca ctgtctgctc cccctgtagt     2400

gccaggcttc tgttgcacag ttggagtgga ctggaagtct ctcactactc cggcgtgcct     2460

cccccttacc accgactact tccctgaccg ccagggcctg cagaatgact acacagaggg     2520

ctgttatgat ctccttccag aagcagacat cgacaggagg gacgaagatg gtgtgcagat     2580

gacagcccag caggtatttg aagagtttat ttgccaacgt ctcatgcagg gctaccaaat     2640

catagtgcag cccaagacac agaaacccaa tcctgctgtc ccgcccccgc tgagcagtag     2700

cccactctat agccgaggcc ttgtgtcctg aaaccgccct gaggaggagg accagtattg     2760

gctgagtatg ggcagaacgt tccacaaagt gacgctgaag gataagatga tcacagtgac     2820

gcgatacctt cccaagtatc cttatgaatc tgcccagatc cactacacct acagcctctg     2880

tccttcccac tcagactcag agttcgtctc ctgctgggtg gaattctccc acgaacggct     2940

ggaggagtac aagtggaatt acttagatca gtatatctgt tctgccggct ctgaagactt     3000

cagcttaatt gagtccctga agttctggag gacccgcttc ctgctgctgc cagcctgtgt     3060

caccgccacc aagcgcatca cggaggggga ggcccactgc gacatctatg gggacaggcc     3120

ccgtgcagac gaggacgagt ggcaactcct ggatggtttt gtccgctttg tggagggctt     3180

gaatcgcatt cgcaggcggc atcgctcgga tcgcatgatg cggaaaggga ccgccatgaa     3240

aggcttgcag atgactgggc ccatttccac gcattctctg gagtcaactg cacccccagt     3300

ggggaagaag ggaacctcag ctctctctgc cctgttggag atggaggcca gtcagaagtg     3360

cctgggagaa cagcaggcag ctgtgcatgg tgggaagagc tccgcccagt cagccgagag     3420

cagcagcgtt gccatgactc ccacctacat ggacagccca cgaaaggacg gggccttctt     3480

tatggagttt gtccgcagcc cacgcacagc atcgtccgcc ttctaccctc aggtatctgt     3540

ggaccaaaca gccactccta tgttggacgg caccagtttg ggcatatgca caggccaatc     3600

catggacaga ggcaacagcc agacctttgg gaactcccag aacataggag aacagggcta     3660

ctcctccaca aactccagtg acagcagctc tcagcagctg gtggcaagct ccttgacctc     3720

atcctctacc ctgacagaga tcctggaagc catgaagcac ccctcgacag gagtccagct     3780

gctctctgaa cagaagggcc tctcaccgta ctgcttcatc agcgcggagg tggtacactg     3840

gttggtgaac cacgtggagg ggatccagac acaggcgatg gccattgaca tcatgcagaa     3900

aatgctggaa gagcagctca tcacacatgc atctggcgaa gcctggcgga ccttcatcta     3960

cggcttctat ttctacaaga tagtaacgga caaagagccc gaccgagtgg ccatgcagca     4020

gcccgccacc acctggcaca cagcaggagt ggacgacttc gccagcttcc agcgcaagtg     4080

gtttgaggtg gcctttgtgg cagaagagct cgtgcactct gagattcctg cctttctcct     4140

gccctggctg cctagccggc cagcctccta tgcaagtagg cacagctcct ttagccgaag     4200

ttttggagga cggagccagg cggcagcact tttagctgcc actgtcccag agcagaggac     4260

tgtgaccctg gatgttgacg tgaacaaccg cacagaccgg ctggagtggt gcagctgtta     4320

ttaccatggc aacttttctc tgaatgcagc ctttgagatc aagctgcact ggatggcggt     4380

gaccgcagca gtactcttcg agatggtcca aggttggcat cggaaagcca cctcctgtgg     4440

cttcttgtta gtcccagttt tggaggggcc ttttgcactg cccagttacc tgtatggcga     4500

cccccttcgt gcccagctct tcatcccact caacatcagc tgcttgctca aggagggcag     4560

cgagcacctg tttgatagct ttgaacccga aacgtactgg gatcgaatgc acctcttcca     4620

ggaagccatt gcacacaggt ttgggtttgt acaagataaa tattctgcct ctgcttttaa     4680

cttccctgct gagaacaagc ctcagtatat ccacgttaca ggaacagtgt ttctgcagct     4740

gccctactcc aagcgcaagt tctcagggca gcagcggcgg cggcggaact ccaccagctc     4800

caccaaccag aacatgttct gcgaggagcg ggtcggctac aactgggcct acaacaccat     4860

gctcaccaaa acatggcgct ccagcgccac aggggatgaa aagtttgctg atcggctgct     4920

gaaggacttc acggacttct gcatcaaccg tgacaaccgg ctggtcacgt tctggacaag     4980

ttgcctggag aagatgcatg ccagtgcccc gtgaggccag gctgcacctg tgctggggga     5040

aggtgggtga gccactgccc tcaaacccgg ggcggaggat tccaggcagg ctctaggagt     5100

caggtgtccg tttgctgcta tcagtgagtg ggggccattg ttttttgttt gtttgtttgt     5160

ttgtttgttt gtttttggcc cccacgacaa gtcttctact ctagaagaaa gactttggaa     5220

gcagctgctg ctgctgccac cactcctgtc agcaagtgct cagagcaggt gggaggcaca     5280

gattgtccgt gggagggctc cagtgtctgg gaagagggca ggcggccccc atgaatgtcc     5340

tcggaagggg gtggctcctg gtagcatcct tttccttcac catctatggg atattagggg     5400

cagaatctgc cacttcttgc ccaggagtgt gcacagatgt aagataattt tgtgaaataa     5460

tgtaccatag actctcacca actgtatata cctgtacata tcagaagcaa ataaagagct     5520

ccacgtgcat catttctttc cccacccagt t                                    5551


<210>  14
<211>  842
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Arg Thr Thr Lys Val Tyr Lys Leu Val Ile His Lys Lys Gly Phe 
1               5                   10                  15      


Gly Gly Ser Asp Asp Glu Leu Val Val Asn Pro Lys Val Phe Pro His 
            20                  25                  30          


Ile Lys Leu Gly Asp Ile Val Glu Ile Ala His Pro Asn Asp Glu Tyr 
        35                  40                  45              


Ser Pro Leu Leu Leu Gln Val Lys Ser Leu Lys Glu Asp Leu Gln Lys 
    50                  55                  60                  


Glu Thr Ile Ser Val Asp Gln Thr Val Thr Gln Val Phe Arg Leu Arg 
65                  70                  75                  80  


Pro Tyr Gln Asp Val Tyr Val Asn Val Val Asp Pro Lys Asp Val Thr 
                85                  90                  95      


Leu Asp Leu Val Glu Leu Thr Phe Lys Asp Gln Tyr Ile Gly Arg Gly 
            100                 105                 110         


Asp Met Trp Arg Leu Lys Lys Ser Leu Val Ser Thr Cys Ala Tyr Ile 
        115                 120                 125             


Thr Gln Lys Val Glu Phe Ala Gly Ile Arg Ala Gln Ala Gly Glu Leu 
    130                 135                 140                 


Trp Val Lys Asn Glu Lys Val Met Cys Gly Tyr Ile Ser Glu Asp Thr 
145                 150                 155                 160 


Arg Val Val Phe Arg Ser Thr Ser Ala Met Val Tyr Ile Phe Ile Gln 
                165                 170                 175     


Met Ser Cys Glu Met Trp Asp Phe Asp Ile Tyr Gly Asp Leu Tyr Phe 
            180                 185                 190         


Glu Lys Ala Val Asn Gly Phe Leu Ala Asp Leu Phe Thr Lys Trp Lys 
        195                 200                 205             


Glu Lys Asn Cys Ser His Glu Val Thr Val Val Leu Phe Ser Arg Thr 
    210                 215                 220                 


Phe Tyr Asp Ala Lys Ser Val Asp Glu Phe Pro Glu Ile Asn Arg Ala 
225                 230                 235                 240 


Ser Ile Arg Gln Asp His Lys Gly Arg Phe Tyr Glu Asp Phe Tyr Lys 
                245                 250                 255     


Val Val Val Gln Asn Glu Arg Arg Glu Glu Trp Thr Ser Leu Leu Val 
            260                 265                 270         


Thr Ile Lys Lys Leu Phe Ile Gln Tyr Pro Val Leu Val Arg Leu Glu 
        275                 280                 285             


Gln Ala Glu Gly Phe Pro Gln Gly Asp Asn Ser Thr Ser Ala Gln Gly 
    290                 295                 300                 


Asn Tyr Leu Glu Ala Ile Asn Leu Ser Phe Asn Val Phe Asp Lys His 
305                 310                 315                 320 


Tyr Ile Asn Arg Asn Phe Asp Arg Thr Gly Gln Met Ser Val Val Ile 
                325                 330                 335     


Thr Pro Gly Val Gly Val Phe Glu Val Asp Arg Leu Leu Met Ile Leu 
            340                 345                 350         


Thr Lys Gln Arg Met Ile Asp Asn Gly Ile Gly Val Asp Leu Val Cys 
        355                 360                 365             


Met Gly Glu Gln Pro Leu His Ala Val Pro Leu Phe Lys Leu His Asn 
    370                 375                 380                 


Arg Ser Ala Pro Arg Asp Ser Arg Leu Gly Asp Asp Tyr Asn Ile Pro 
385                 390                 395                 400 


His Trp Ile Asn His Ser Phe Tyr Thr Ser Lys Ser Gln Leu Phe Cys 
                405                 410                 415     


Asn Ser Phe Thr Pro Arg Ile Lys Leu Ala Gly Lys Lys Pro Ala Ser 
            420                 425                 430         


Glu Lys Ala Lys Asn Gly Arg Asp Thr Ser Leu Gly Ser Pro Lys Glu 
        435                 440                 445             


Ser Glu Asn Ala Leu Pro Ile Gln Val Asp Tyr Asp Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Val Phe Arg Leu Pro Gly Pro Ser Arg Ala Gln Cys Leu Thr Thr 
465                 470                 475                 480 


Cys Arg Ser Val Arg Glu Arg Glu Ser His Ser Arg Lys Ser Ala Ser 
                485                 490                 495     


Ser Cys Asp Val Ser Ser Ser Pro Ser Leu Pro Ser Arg Thr Leu Pro 
            500                 505                 510         


Thr Glu Glu Val Arg Ser Gln Ala Ser Asp Asp Ser Ser Leu Gly Lys 
        515                 520                 525             


Ser Ala Asn Ile Leu Met Ile Pro His Pro His Leu His Gln Tyr Glu 
    530                 535                 540                 


Val Ser Ser Ser Leu Gly Tyr Thr Ser Thr Arg Asp Val Leu Glu Asn 
545                 550                 555                 560 


Met Met Glu Pro Pro Gln Arg Asp Ser Ser Ala Pro Gly Arg Phe His 
                565                 570                 575     


Val Gly Ser Ala Glu Ser Met Leu His Val Arg Pro Gly Gly Tyr Thr 
            580                 585                 590         


Pro Gln Arg Ala Leu Ile Asn Pro Phe Ala Pro Ser Arg Met Pro Met 
        595                 600                 605             


Lys Leu Thr Ser Asn Arg Arg Arg Trp Met His Thr Phe Pro Val Gly 
    610                 615                 620                 


Pro Ser Gly Glu Ala Ile Gln Ile His His Gln Thr Arg Gln Asn Met 
625                 630                 635                 640 


Ala Glu Leu Gln Gly Ser Gly Gln Arg Asp Pro Thr His Ser Ser Ala 
                645                 650                 655     


Glu Leu Leu Glu Leu Ala Tyr His Glu Ala Ala Gly Arg His Ser Asn 
            660                 665                 670         


Ser Arg Gln Pro Gly Asp Gly Met Ser Phe Leu Asn Phe Ser Gly Thr 
        675                 680                 685             


Glu Glu Leu Ser Val Gly Leu Leu Ser Asn Ser Gly Ala Gly Met Asn 
    690                 695                 700                 


Pro Arg Thr Gln Asn Lys Asp Ser Leu Glu Asp Ser Val Ser Thr Ser 
705                 710                 715                 720 


Pro Asp Pro Ile Leu Thr Leu Ser Ala Pro Pro Val Val Pro Gly Phe 
                725                 730                 735     


Cys Cys Thr Val Gly Val Asp Trp Lys Ser Leu Thr Thr Pro Ala Cys 
            740                 745                 750         


Leu Pro Leu Thr Thr Asp Tyr Phe Pro Asp Arg Gln Gly Leu Gln Asn 
        755                 760                 765             


Asp Tyr Thr Glu Gly Cys Tyr Asp Leu Leu Pro Glu Ala Asp Ile Asp 
    770                 775                 780                 


Arg Arg Asp Glu Asp Gly Val Gln Met Thr Ala Gln Gln Val Phe Glu 
785                 790                 795                 800 


Glu Phe Ile Cys Gln Arg Leu Met Gln Gly Tyr Gln Ile Ile Val Gln 
                805                 810                 815     


Pro Lys Thr Gln Lys Pro Asn Pro Ala Val Pro Pro Pro Leu Ser Ser 
            820                 825                 830         


Ser Pro Leu Tyr Ser Arg Gly Leu Val Ser 
        835                 840         


<210>  15
<211>  5551
<212>  DNA
<213>  Homo sapiens

<400>  15
ctagtaggcg cttcaggctt aggggcggaa cagcgcgggc cgcgcgggcg taggcggggt       60

atctggagga ggcgcaggga acctggagag ggtccagccc tcagtgcccc ggccagaggc      120

gggaaggggc tctagagctt cgggaggcaa gatgacttct ctgccccaag cttggaacag      180

ctaaagggaa aaacagtgca agatgagaac aacaaaggtc tacaaactcg tcatccacaa      240

gaagggcttt gggggcagtg atgatgagct agttgtgaac cccaaagtgt tccctcacat      300

caagcttgga gacattgtag agattgcaca ccccaacgat gaatacagcc ctctgctttt      360

gcaggtcaag tctcttaagg aagatttaca gaaggaaact atcagtgtgg accagactgt      420

gactcaagtg ttccggctga gaccttatca ggatgtctat gttaatgtcg tagaccctaa      480

ggatgtgacc cttgacctag tggaattaac ttttaaggat cagtatattg gccgtgggga      540

tatgtggcga ctaaagaaaa gtttggtcag cacatgtgcc tatatcaccc agaaggtgga      600

gtttgctggc atcagagcac aggctggtga actgtgggtt aagaatgaga aggtcatgtg      660

tggctacatc agtgaagata ccagggtggt gtttcgttct acgtcggcta tggtttacat      720

atttattcag atgagctgtg aaatgtggga ttttgatatt tatggggatt tgtattttga      780

gaaagctgtg aatggtttcc ttgctgatct atttaccaag tggaaggaga agaactgtag      840

tcatgaagtg acagtggtcc tgttttctag aactttctat gatgcaaaat ctgttgatga      900

atttcctgaa ataaaccgag cctcaattcg acaggatcac aaggggagat tctatgaaga      960

cttttacaaa gtggtggtgc agaatgagag aagagaagaa tggacttcac ttctcgtaac     1020

cattaaaaaa ctcttcatcc agtatccagt gttggtgcga ctggaacagg cagagggctt     1080

tcctcaagga gataattcta cctcagcaca aggaaactac ctggaggcca tcaatctgtc     1140

attcaatgtg tttgataagc actacatcaa ccgcaacttt gaccgaactg ggcagatgtc     1200

agtggtgatc acgcccgggg tgggtgtctt tgaagtggac cgcctactca tgatcctgac     1260

caagcagcgg atgatagata atggaattgg tgtggatttg gtgtgcatgg gagagcaacc     1320

gttacatgct gtcccattgt tcaagctcca taatcggagt gctccccgtg attctcgtct     1380

gggcgatgac tataatatcc ctcactggat aaaccacagt ttctacacat ccaaaagcca     1440

gctcttttgt aatagtttca ccccacgaat aaaactggca ggaaagaagc ccgcctctga     1500

gaaagcaaaa aatggccgtg atacatctct cgggagtcca aaagaatctg agaacgccct     1560

tcccatccaa gtagattatg acgcctatga cgctcaagtg ttcaggctgc ccggcccatc     1620

ccgggcccag tgcctcacca cctgcagatc tgtgcgagag cgagagagtc acagtcgaaa     1680

gagtgccagc tcctgtgatg tttcatccag cccttcccta ccaagccgca cactgcccac     1740

tgaggaagtg aggagccagg cttctgacga cagctcccta ggcaagagtg ccaacatcct     1800

gatgatccca cacccccacc tgcaccagta tgaagtcagc agctccttgg gatacaccag     1860

cactcgagat gtcctggaga acatgatgga gccaccacag cgagactcca gtgcaccagg     1920

gaggtttcac gttggcagtg cagaatccat gctgcatgtt cgacctggtg gatacacgcc     1980

ccagagagca ctgattaacc ccttcgctcc ctctcggatg cccatgaagc ttacgtccaa     2040

cagaaggcgc tggatgcaca cttttcctgt ggggccatcc ggagaagcca tccagatcca     2100

ccaccagacc cgacagaata tggcggagct acaaggcagc gggcagaggg atccaactca     2160

ctcctctgca gagctgctgg agttagcata tcatgaagct gctggaaggc acagcaattc     2220

ccgccagcct ggtgacggca tgtccttctt gaacttcagt ggaacagagg agctttctgt     2280

cggcctgctt agcaacagtg gtgcaggtat gaatcctagg acccagaata aggattctct     2340

agaggacagt gtttctacct ctccagaccc aattctgaca ctgtctgctc cccctgtagt     2400

gccaggcttc tgttgcacag ttggagtgga ctggaagtct ctcactactc cggcgtgcct     2460

cccccttacc accgactact tccctgaccg ccagggcctg cagaatgact acacagaggg     2520

ctgttatgat ctccttccag aagcagacat cgacaggagg gacgaagatg gtgtgcagat     2580

gacagcccag caggtatttg aagagtttat ttgccaacgt ctcatgcagg gctaccaaat     2640

catagtgcag cccaagacac agaaacccaa tcctgctgtc ccgcccccgc tgagcagtag     2700

cccactctat agccgaggcc ttgtgtcccg aaaccgccct gaggaggagg accagtattg     2760

gctgagtatg ggcagaacgt tccacaaagt gacgctgaag gataagatga tcacagtgac     2820

gcgatacctt cccaagtatc cttatgaatc tgcccagatc cactacacct acagcctctg     2880

tccttcccac tcagactcag agttcgtctc ctgctgggtg gaattctccc acgaacggct     2940

ggaggagtac aagtggaatt acttagatca gtatatctgt tctgccggct ctgaagactt     3000

cagcttaatt gagtccctga agttctggag gacccgcttc ctgctgctgc cagcctgtgt     3060

caccgccacc aagcgcatca cggaggggga ggcccactgc gacatctatg gggacaggcc     3120

ccgtgcagac gaggacgagt ggcaactcct ggatggtttt gtccgctttg tggagggctt     3180

gaatcgcatt cgcaggcggc atcgctcgga tcgcatgatg cggaaaggga ccgccatgaa     3240

aggcttgcag atgactgggc ccatttccac gcattctctg gagtcaactg cacccccagt     3300

ggggaagaag ggaacctcag ctctctctgc cctgttggag atggaggcca gtcagaagtg     3360

cctgggagaa cagcaggcag ctgtgcatgg tgggaagagc tccgcccagt cagccgagag     3420

cagcagcgtt gccatgactc ccacctacat ggacagccca cgaaaggacg gggccttctt     3480

tatggagttt gtccgcagcc cacgcacagc atcgtccgcc ttctaccctc aggtatctgt     3540

ggaccaaaca gccactccta tgttggacgg caccagtttg ggcatatgca caggccaatc     3600

catggacaga ggcaacagcc agacctttgg gaactcccag aacataggag aacagggcta     3660

ctcctccaca aactccagtg acagcagctc tcagcagctg gtggcaagct ccttgacctc     3720

atcctctacc ctgacagaga tcctggaagc catgaagcac ccctcgacag gagtccagct     3780

gctctctgaa cagaagggcc tctcaccgta ctgcttcatc agcgcggagg tggtacactg     3840

gttggtgaac cacgtggagg ggatccagac acaggcgatg gccattgaca tcatgcagaa     3900

aatgctggaa gagcagctca tcacacatgc atctggcgaa gcctggcgga ccttcatcta     3960

cggcttctat ttctacaaga tagtaacgga caaagagccc gactgagtgg ccatgcagca     4020

gcccgccacc acctggcaca cagcaggagt ggacgacttc gccagcttcc agcgcaagtg     4080

gtttgaggtg gcctttgtgg cagaagagct cgtgcactct gagattcctg cctttctcct     4140

gccctggctg cctagccggc cagcctccta tgcaagtagg cacagctcct ttagccgaag     4200

ttttggagga cggagccagg cggcagcact tttagctgcc actgtcccag agcagaggac     4260

tgtgaccctg gatgttgacg tgaacaaccg cacagaccgg ctggagtggt gcagctgtta     4320

ttaccatggc aacttttctc tgaatgcagc ctttgagatc aagctgcact ggatggcggt     4380

gaccgcagca gtactcttcg agatggtcca aggttggcat cggaaagcca cctcctgtgg     4440

cttcttgtta gtcccagttt tggaggggcc ttttgcactg cccagttacc tgtatggcga     4500

cccccttcgt gcccagctct tcatcccact caacatcagc tgcttgctca aggagggcag     4560

cgagcacctg tttgatagct ttgaacccga aacgtactgg gatcgaatgc acctcttcca     4620

ggaagccatt gcacacaggt ttgggtttgt acaagataaa tattctgcct ctgcttttaa     4680

cttccctgct gagaacaagc ctcagtatat ccacgttaca ggaacagtgt ttctgcagct     4740

gccctactcc aagcgcaagt tctcagggca gcagcggcgg cggcggaact ccaccagctc     4800

caccaaccag aacatgttct gcgaggagcg ggtcggctac aactgggcct acaacaccat     4860

gctcaccaaa acatggcgct ccagcgccac aggggatgaa aagtttgctg atcggctgct     4920

gaaggacttc acggacttct gcatcaaccg tgacaaccgg ctggtcacgt tctggacaag     4980

ttgcctggag aagatgcatg ccagtgcccc gtgaggccag gctgcacctg tgctggggga     5040

aggtgggtga gccactgccc tcaaacccgg ggcggaggat tccaggcagg ctctaggagt     5100

caggtgtccg tttgctgcta tcagtgagtg ggggccattg ttttttgttt gtttgtttgt     5160

ttgtttgttt gtttttggcc cccacgacaa gtcttctact ctagaagaaa gactttggaa     5220

gcagctgctg ctgctgccac cactcctgtc agcaagtgct cagagcaggt gggaggcaca     5280

gattgtccgt gggagggctc cagtgtctgg gaagagggca ggcggccccc atgaatgtcc     5340

tcggaagggg gtggctcctg gtagcatcct tttccttcac catctatggg atattagggg     5400

cagaatctgc cacttcttgc ccaggagtgt gcacagatgt aagataattt tgtgaaataa     5460

tgtaccatag actctcacca actgtatata cctgtacata tcagaagcaa ataaagagct     5520

ccacgtgcat catttctttc cccacccagt t                                    5551


<210>  16
<211>  1267
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Arg Thr Thr Lys Val Tyr Lys Leu Val Ile His Lys Lys Gly Phe 
1               5                   10                  15      


Gly Gly Ser Asp Asp Glu Leu Val Val Asn Pro Lys Val Phe Pro His 
            20                  25                  30          


Ile Lys Leu Gly Asp Ile Val Glu Ile Ala His Pro Asn Asp Glu Tyr 
        35                  40                  45              


Ser Pro Leu Leu Leu Gln Val Lys Ser Leu Lys Glu Asp Leu Gln Lys 
    50                  55                  60                  


Glu Thr Ile Ser Val Asp Gln Thr Val Thr Gln Val Phe Arg Leu Arg 
65                  70                  75                  80  


Pro Tyr Gln Asp Val Tyr Val Asn Val Val Asp Pro Lys Asp Val Thr 
                85                  90                  95      


Leu Asp Leu Val Glu Leu Thr Phe Lys Asp Gln Tyr Ile Gly Arg Gly 
            100                 105                 110         


Asp Met Trp Arg Leu Lys Lys Ser Leu Val Ser Thr Cys Ala Tyr Ile 
        115                 120                 125             


Thr Gln Lys Val Glu Phe Ala Gly Ile Arg Ala Gln Ala Gly Glu Leu 
    130                 135                 140                 


Trp Val Lys Asn Glu Lys Val Met Cys Gly Tyr Ile Ser Glu Asp Thr 
145                 150                 155                 160 


Arg Val Val Phe Arg Ser Thr Ser Ala Met Val Tyr Ile Phe Ile Gln 
                165                 170                 175     


Met Ser Cys Glu Met Trp Asp Phe Asp Ile Tyr Gly Asp Leu Tyr Phe 
            180                 185                 190         


Glu Lys Ala Val Asn Gly Phe Leu Ala Asp Leu Phe Thr Lys Trp Lys 
        195                 200                 205             


Glu Lys Asn Cys Ser His Glu Val Thr Val Val Leu Phe Ser Arg Thr 
    210                 215                 220                 


Phe Tyr Asp Ala Lys Ser Val Asp Glu Phe Pro Glu Ile Asn Arg Ala 
225                 230                 235                 240 


Ser Ile Arg Gln Asp His Lys Gly Arg Phe Tyr Glu Asp Phe Tyr Lys 
                245                 250                 255     


Val Val Val Gln Asn Glu Arg Arg Glu Glu Trp Thr Ser Leu Leu Val 
            260                 265                 270         


Thr Ile Lys Lys Leu Phe Ile Gln Tyr Pro Val Leu Val Arg Leu Glu 
        275                 280                 285             


Gln Ala Glu Gly Phe Pro Gln Gly Asp Asn Ser Thr Ser Ala Gln Gly 
    290                 295                 300                 


Asn Tyr Leu Glu Ala Ile Asn Leu Ser Phe Asn Val Phe Asp Lys His 
305                 310                 315                 320 


Tyr Ile Asn Arg Asn Phe Asp Arg Thr Gly Gln Met Ser Val Val Ile 
                325                 330                 335     


Thr Pro Gly Val Gly Val Phe Glu Val Asp Arg Leu Leu Met Ile Leu 
            340                 345                 350         


Thr Lys Gln Arg Met Ile Asp Asn Gly Ile Gly Val Asp Leu Val Cys 
        355                 360                 365             


Met Gly Glu Gln Pro Leu His Ala Val Pro Leu Phe Lys Leu His Asn 
    370                 375                 380                 


Arg Ser Ala Pro Arg Asp Ser Arg Leu Gly Asp Asp Tyr Asn Ile Pro 
385                 390                 395                 400 


His Trp Ile Asn His Ser Phe Tyr Thr Ser Lys Ser Gln Leu Phe Cys 
                405                 410                 415     


Asn Ser Phe Thr Pro Arg Ile Lys Leu Ala Gly Lys Lys Pro Ala Ser 
            420                 425                 430         


Glu Lys Ala Lys Asn Gly Arg Asp Thr Ser Leu Gly Ser Pro Lys Glu 
        435                 440                 445             


Ser Glu Asn Ala Leu Pro Ile Gln Val Asp Tyr Asp Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Val Phe Arg Leu Pro Gly Pro Ser Arg Ala Gln Cys Leu Thr Thr 
465                 470                 475                 480 


Cys Arg Ser Val Arg Glu Arg Glu Ser His Ser Arg Lys Ser Ala Ser 
                485                 490                 495     


Ser Cys Asp Val Ser Ser Ser Pro Ser Leu Pro Ser Arg Thr Leu Pro 
            500                 505                 510         


Thr Glu Glu Val Arg Ser Gln Ala Ser Asp Asp Ser Ser Leu Gly Lys 
        515                 520                 525             


Ser Ala Asn Ile Leu Met Ile Pro His Pro His Leu His Gln Tyr Glu 
    530                 535                 540                 


Val Ser Ser Ser Leu Gly Tyr Thr Ser Thr Arg Asp Val Leu Glu Asn 
545                 550                 555                 560 


Met Met Glu Pro Pro Gln Arg Asp Ser Ser Ala Pro Gly Arg Phe His 
                565                 570                 575     


Val Gly Ser Ala Glu Ser Met Leu His Val Arg Pro Gly Gly Tyr Thr 
            580                 585                 590         


Pro Gln Arg Ala Leu Ile Asn Pro Phe Ala Pro Ser Arg Met Pro Met 
        595                 600                 605             


Lys Leu Thr Ser Asn Arg Arg Arg Trp Met His Thr Phe Pro Val Gly 
    610                 615                 620                 


Pro Ser Gly Glu Ala Ile Gln Ile His His Gln Thr Arg Gln Asn Met 
625                 630                 635                 640 


Ala Glu Leu Gln Gly Ser Gly Gln Arg Asp Pro Thr His Ser Ser Ala 
                645                 650                 655     


Glu Leu Leu Glu Leu Ala Tyr His Glu Ala Ala Gly Arg His Ser Asn 
            660                 665                 670         


Ser Arg Gln Pro Gly Asp Gly Met Ser Phe Leu Asn Phe Ser Gly Thr 
        675                 680                 685             


Glu Glu Leu Ser Val Gly Leu Leu Ser Asn Ser Gly Ala Gly Met Asn 
    690                 695                 700                 


Pro Arg Thr Gln Asn Lys Asp Ser Leu Glu Asp Ser Val Ser Thr Ser 
705                 710                 715                 720 


Pro Asp Pro Ile Leu Thr Leu Ser Ala Pro Pro Val Val Pro Gly Phe 
                725                 730                 735     


Cys Cys Thr Val Gly Val Asp Trp Lys Ser Leu Thr Thr Pro Ala Cys 
            740                 745                 750         


Leu Pro Leu Thr Thr Asp Tyr Phe Pro Asp Arg Gln Gly Leu Gln Asn 
        755                 760                 765             


Asp Tyr Thr Glu Gly Cys Tyr Asp Leu Leu Pro Glu Ala Asp Ile Asp 
    770                 775                 780                 


Arg Arg Asp Glu Asp Gly Val Gln Met Thr Ala Gln Gln Val Phe Glu 
785                 790                 795                 800 


Glu Phe Ile Cys Gln Arg Leu Met Gln Gly Tyr Gln Ile Ile Val Gln 
                805                 810                 815     


Pro Lys Thr Gln Lys Pro Asn Pro Ala Val Pro Pro Pro Leu Ser Ser 
            820                 825                 830         


Ser Pro Leu Tyr Ser Arg Gly Leu Val Ser Arg Asn Arg Pro Glu Glu 
        835                 840                 845             


Glu Asp Gln Tyr Trp Leu Ser Met Gly Arg Thr Phe His Lys Val Thr 
    850                 855                 860                 


Leu Lys Asp Lys Met Ile Thr Val Thr Arg Tyr Leu Pro Lys Tyr Pro 
865                 870                 875                 880 


Tyr Glu Ser Ala Gln Ile His Tyr Thr Tyr Ser Leu Cys Pro Ser His 
                885                 890                 895     


Ser Asp Ser Glu Phe Val Ser Cys Trp Val Glu Phe Ser His Glu Arg 
            900                 905                 910         


Leu Glu Glu Tyr Lys Trp Asn Tyr Leu Asp Gln Tyr Ile Cys Ser Ala 
        915                 920                 925             


Gly Ser Glu Asp Phe Ser Leu Ile Glu Ser Leu Lys Phe Trp Arg Thr 
    930                 935                 940                 


Arg Phe Leu Leu Leu Pro Ala Cys Val Thr Ala Thr Lys Arg Ile Thr 
945                 950                 955                 960 


Glu Gly Glu Ala His Cys Asp Ile Tyr Gly Asp Arg Pro Arg Ala Asp 
                965                 970                 975     


Glu Asp Glu Trp Gln Leu Leu Asp Gly Phe Val Arg Phe Val Glu Gly 
            980                 985                 990         


Leu Asn Arg Ile Arg Arg Arg His  Arg Ser Asp Arg Met  Met Arg Lys 
        995                 1000                 1005             


Gly Thr  Ala Met Lys Gly Leu  Gln Met Thr Gly Pro  Ile Ser Thr 
    1010                 1015                 1020             


His Ser  Leu Glu Ser Thr Ala  Pro Pro Val Gly Lys  Lys Gly Thr 
    1025                 1030                 1035             


Ser Ala  Leu Ser Ala Leu Leu  Glu Met Glu Ala Ser  Gln Lys Cys 
    1040                 1045                 1050             


Leu Gly  Glu Gln Gln Ala Ala  Val His Gly Gly Lys  Ser Ser Ala 
    1055                 1060                 1065             


Gln Ser  Ala Glu Ser Ser Ser  Val Ala Met Thr Pro  Thr Tyr Met 
    1070                 1075                 1080             


Asp Ser  Pro Arg Lys Asp Gly  Ala Phe Phe Met Glu  Phe Val Arg 
    1085                 1090                 1095             


Ser Pro  Arg Thr Ala Ser Ser  Ala Phe Tyr Pro Gln  Val Ser Val 
    1100                 1105                 1110             


Asp Gln  Thr Ala Thr Pro Met  Leu Asp Gly Thr Ser  Leu Gly Ile 
    1115                 1120                 1125             


Cys Thr  Gly Gln Ser Met Asp  Arg Gly Asn Ser Gln  Thr Phe Gly 
    1130                 1135                 1140             


Asn Ser  Gln Asn Ile Gly Glu  Gln Gly Tyr Ser Ser  Thr Asn Ser 
    1145                 1150                 1155             


Ser Asp  Ser Ser Ser Gln Gln  Leu Val Ala Ser Ser  Leu Thr Ser 
    1160                 1165                 1170             


Ser Ser  Thr Leu Thr Glu Ile  Leu Glu Ala Met Lys  His Pro Ser 
    1175                 1180                 1185             


Thr Gly  Val Gln Leu Leu Ser  Glu Gln Lys Gly Leu  Ser Pro Tyr 
    1190                 1195                 1200             


Cys Phe  Ile Ser Ala Glu Val  Val His Trp Leu Val  Asn His Val 
    1205                 1210                 1215             


Glu Gly  Ile Gln Thr Gln Ala  Met Ala Ile Asp Ile  Met Gln Lys 
    1220                 1225                 1230             


Met Leu  Glu Glu Gln Leu Ile  Thr His Ala Ser Gly  Glu Ala Trp 
    1235                 1240                 1245             


Arg Thr  Phe Ile Tyr Gly Phe  Tyr Phe Tyr Lys Ile  Val Thr Asp 
    1250                 1255                 1260             


Lys Glu  Pro Asp 
    1265         


<210>  17
<211>  5548
<212>  DNA
<213>  Homo sapiens

<400>  17
ctagtaggcg cttcaggctt aggggcggaa cagcgcgggc cgcgcgggcg taggcggggt       60

atctggagga ggcgcaggga acctggagag ggtccagccc tcagtgcccc ggccagaggc      120

gggaaggggc tctagagctt cgggaggcaa gatgacttct ctgccccaag cttggaacag      180

ctaaagggaa aaacagtgca agatgagaac aacaaaggtc tacaaactcg tcatccacaa      240

gaagggcttt gggggcagtg atgatgagct agttgtgaac cccaaagtgt tccctcacat      300

caagcttgga gacattgtag agattgcaca ccccaacgat gaatacagcc ctctgctttt      360

gcaggtcaag tctcttaagg aagatttaca gaaggaaact atcagtgtgg accagactgt      420

gactcaagtg ttccggctga gaccttatca ggatgtctat gttaatgtcg tagaccctaa      480

ggatgtgacc cttgacctag tggaattaac ttttaaggat cagtatattg gccgtgggga      540

tatgtggcga ctaaagaaaa gtttggtcag cacatgtgcc tatatcaccc agaaggtgga      600

gtttgctggc atcagagcac aggctggtga actgtgggtt aagaatgaga aggtcatgtg      660

tggctacatc agtgaagata ccagggtggt tcgttctacg tcggctatgg tttacatatt      720

tattcagatg agctgtgaaa tgtgggattt tgatatttat ggggatttgt attttgagaa      780

agctgtgaat ggtttccttg ctgatctatt taccaagtgg aaggagaaga actgtagtca      840

tgaagtgaca gtggtcctgt tttctagaac tttctatgat gcaaaatctg ttgatgaatt      900

tcctgaaata aaccgagcct caattcgaca ggatcacaag gggagattct atgaagactt      960

ttacaaagtg gtggtgcaga atgagagaag agaagaatgg acttcacttc tcgtaaccat     1020

taaaaaactc ttcatccagt atccagtgtt ggtgcgactg gaacaggcag agggctttcc     1080

tcaaggagat aattctacct cagcacaagg aaactacctg gaggccatca atctgtcatt     1140

caatgtgttt gataagcact acatcaaccg caactttgac cgaactgggc agatgtcagt     1200

ggtgatcacg cccggggtgg gtgtctttga agtggaccgc ctactcatga tcctgaccaa     1260

gcagcggatg atagataatg gaattggtgt ggatttggtg tgcatgggag agcaaccgtt     1320

acatgctgtc ccattgttca agctccataa tcggagtgct ccccgtgatt ctcgtctggg     1380

cgatgactat aatatccctc actggataaa ccacagtttc tacacatcca aaagccagct     1440

cttttgtaat agtttcaccc cacgaataaa actggcagga aagaagcccg cctctgagaa     1500

agcaaaaaat ggccgtgata catctctcgg gagtccaaaa gaatctgaga acgcccttcc     1560

catccaagta gattatgacg cctatgacgc tcaagtgttc aggctgcccg gcccatcccg     1620

ggcccagtgc ctcaccacct gcagatctgt gcgagagcga gagagtcaca gtcgaaagag     1680

tgccagctcc tgtgatgttt catccagccc ttccctacca agccgcacac tgcccactga     1740

ggaagtgagg agccaggctt ctgacgacag ctccctaggc aagagtgcca acatcctgat     1800

gatcccacac ccccacctgc accagtatga agtcagcagc tccttgggat acaccagcac     1860

tcgagatgtc ctggagaaca tgatggagcc accacagcga gactccagtg caccagggag     1920

gtttcacgtt ggcagtgcag aatccatgct gcatgttcga cctggtggat acacgcccca     1980

gagagcactg attaacccct tcgctccctc tcggatgccc atgaagctta cgtccaacag     2040

aaggcgctgg atgcacactt ttcctgtggg gccatccgga gaagccatcc agatccacca     2100

ccagacccga cagaatatgg cggagctaca aggcagcggg cagagggatc caactcactc     2160

ctctgcagag ctgctggagt tagcatatca tgaagctgct ggaaggcaca gcaattcccg     2220

ccagcctggt gacggcatgt ccttcttgaa cttcagtgga acagaggagc tttctgtcgg     2280

cctgcttagc aacagtggtg caggtatgaa tcctaggacc cagaataagg attctctaga     2340

ggacagtgtt tctacctctc cagacccaat tctgacactg tctgctcccc ctgtagtgcc     2400

aggcttctgt tgcacagttg gagtggactg gaagtctctc actactccgg cgtgcctccc     2460

ccttaccacc gactacttcc ctgaccgcca gggcctgcag aatgactaca cagagggctg     2520

ttatgatctc cttccagaag cagacatcga caggagggac gaagatggtg tgcagatgac     2580

agcccagcag gtatttgaag agtttatttg ccaacgtctc atgcagggct accaaatcat     2640

agtgcagccc aagacacaga aacccaatcc tgctgtcccg cccccgctga gcagtagccc     2700

actctatagc cgaggccttg tgtcccgaaa ccgccctgag gaggaggacc agtattggct     2760

gagtatgggc agaacgttcc acaaagtgac gctgaaggat aagatgatca cagtgacgcg     2820

ataccttccc aagtatcctt atgaatctgc ccagatccac tacacctaca gcctctgtcc     2880

ttcccactca gactcagagt tcgtctcctg ctgggtggaa ttctcccacg aacggctgga     2940

ggagtacaag tggaattact tagatcagta tatctgttct gccggctctg aagacttcag     3000

cttaattgag tccctgaagt tctggaggac ccgcttcctg ctgctgccag cctgtgtcac     3060

cgccaccaag cgcatcacgg agggggaggc ccactgcgac atctatgggg acaggccccg     3120

tgcagacgag gacgagtggc aactcctgga tggttttgtc cgctttgtgg agggcttgaa     3180

tcgcattcgc aggcggcatc gctcggatcg catgatgcgg aaagggaccg ccatgaaagg     3240

cttgcagatg actgggccca tttccacgca ttctctggag tcaactgcac ccccagtggg     3300

gaagaaggga acctcagctc tctctgccct gttggagatg gaggccagtc agaagtgcct     3360

gggagaacag caggcagctg tgcatggtgg gaagagctcc gcccagtcag ccgagagcag     3420

cagcgttgcc atgactccca cctacatgga cagcccacga aaggacgggg ccttctttat     3480

ggagtttgtc cgcagcccac gcacagcatc gtccgccttc taccctcagg tatctgtgga     3540

ccaaacagcc actcctatgt tggacggcac cagtttgggc atatgcacag gccaatccat     3600

ggacagaggc aacagccaga cctttgggaa ctcccagaac ataggagaac agggctactc     3660

ctccacaaac tccagtgaca gcagctctca gcagctggtg gcaagctcct tgacctcatc     3720

ctctaccctg acagagatcc tggaagccat gaagcacccc tcgacaggag tccagctgct     3780

ctctgaacag aagggcctct caccgtactg cttcatcagc gcggaggtgg tacactggtt     3840

ggtgaaccac gtggagggga tccagacaca ggcgatggcc attgacatca tgcagaaaat     3900

gctggaagag cagctcatca cacatgcatc tggcgaagcc tggcggacct tcatctacgg     3960

cttctatttc tacaagatag taacggacaa agagcccgac cgagtggcca tgcagcagcc     4020

cgccaccacc tggcacacag caggagtgga cgacttcgcc agcttccagc gcaagtggtt     4080

tgaggtggcc tttgtggcag aagagctcgt gcactctgag attcctgcct ttctcctgcc     4140

ctggctgcct agccggccag cctcctatgc aagtaggcac agctccttta gccgaagttt     4200

tggaggacgg agccaggcgg cagcactttt agctgccact gtcccagagc agaggactgt     4260

gaccctggat gttgacgtga acaaccgcac agaccggctg gagtggtgca gctgttatta     4320

ccatggcaac ttttctctga atgcagcctt tgagatcaag ctgcactgga tggcggtgac     4380

cgcagcagta ctcttcgaga tggtccaagg ttggcatcgg aaagccacct cctgtggctt     4440

cttgttagtc ccagttttgg aggggccttt tgcactgccc agttacctgt atggcgaccc     4500

ccttcgtgcc cagctcttca tcccactcaa catcagctgc ttgctcaagg agggcagcga     4560

gcacctgttt gatagctttg aacccgaaac gtactgggat cgaatgcacc tcttccagga     4620

agccattgca cacaggtttg ggtttgtaca agataaatat tctgcctctg cttttaactt     4680

ccctgctgag aacaagcctc agtatatcca cgttacagga acagtgtttc tgcagctgcc     4740

ctactccaag cgcaagttct cagggcagca gcggcggcgg cggaactcca ccagctccac     4800

caaccagaac atgttctgcg aggagcgggt cggctacaac tgggcctaca acaccatgct     4860

caccaaaaca tggcgctcca gcgccacagg ggatgaaaag tttgctgatc ggctgctgaa     4920

ggacttcacg gacttctgca tcaaccgtga caaccggctg gtcacgttct ggacaagttg     4980

cctggagaag atgcatgcca gtgccccgtg aggccaggct gcacctgtgc tgggggaagg     5040

tgggtgagcc actgccctca aacccggggc ggaggattcc aggcaggctc taggagtcag     5100

gtgtccgttt gctgctatca gtgagtgggg gccattgttt tttgtttgtt tgtttgtttg     5160

tttgtttgtt tttggccccc acgacaagtc ttctactcta gaagaaagac tttggaagca     5220

gctgctgctg ctgccaccac tcctgtcagc aagtgctcag agcaggtggg aggcacagat     5280

tgtccgtggg agggctccag tgtctgggaa gagggcaggc ggcccccatg aatgtcctcg     5340

gaagggggtg gctcctggta gcatcctttt ccttcaccat ctatgggata ttaggggcag     5400

aatctgccac ttcttgccca ggagtgtgca cagatgtaag ataattttgt gaaataatgt     5460

accatagact ctcaccaact gtatatacct gtacatatca gaagcaaata aagagctcca     5520

cgtgcatcat ttctttcccc acccagtt                                        5548


<210>  18
<211>  1602
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Arg Thr Thr Lys Val Tyr Lys Leu Val Ile His Lys Lys Gly Phe 
1               5                   10                  15      


Gly Gly Ser Asp Asp Glu Leu Val Val Asn Pro Lys Val Phe Pro His 
            20                  25                  30          


Ile Lys Leu Gly Asp Ile Val Glu Ile Ala His Pro Asn Asp Glu Tyr 
        35                  40                  45              


Ser Pro Leu Leu Leu Gln Val Lys Ser Leu Lys Glu Asp Leu Gln Lys 
    50                  55                  60                  


Glu Thr Ile Ser Val Asp Gln Thr Val Thr Gln Val Phe Arg Leu Arg 
65                  70                  75                  80  


Pro Tyr Gln Asp Val Tyr Val Asn Val Val Asp Pro Lys Asp Val Thr 
                85                  90                  95      


Leu Asp Leu Val Glu Leu Thr Phe Lys Asp Gln Tyr Ile Gly Arg Gly 
            100                 105                 110         


Asp Met Trp Arg Leu Lys Lys Ser Leu Val Ser Thr Cys Ala Tyr Ile 
        115                 120                 125             


Thr Gln Lys Val Glu Phe Ala Gly Ile Arg Ala Gln Ala Gly Glu Leu 
    130                 135                 140                 


Trp Val Lys Asn Glu Lys Val Met Cys Gly Tyr Ile Ser Glu Asp Thr 
145                 150                 155                 160 


Arg Val Val Arg Ser Thr Ser Ala Met Val Tyr Ile Phe Ile Gln Met 
                165                 170                 175     


Ser Cys Glu Met Trp Asp Phe Asp Ile Tyr Gly Asp Leu Tyr Phe Glu 
            180                 185                 190         


Lys Ala Val Asn Gly Phe Leu Ala Asp Leu Phe Thr Lys Trp Lys Glu 
        195                 200                 205             


Lys Asn Cys Ser His Glu Val Thr Val Val Leu Phe Ser Arg Thr Phe 
    210                 215                 220                 


Tyr Asp Ala Lys Ser Val Asp Glu Phe Pro Glu Ile Asn Arg Ala Ser 
225                 230                 235                 240 


Ile Arg Gln Asp His Lys Gly Arg Phe Tyr Glu Asp Phe Tyr Lys Val 
                245                 250                 255     


Val Val Gln Asn Glu Arg Arg Glu Glu Trp Thr Ser Leu Leu Val Thr 
            260                 265                 270         


Ile Lys Lys Leu Phe Ile Gln Tyr Pro Val Leu Val Arg Leu Glu Gln 
        275                 280                 285             


Ala Glu Gly Phe Pro Gln Gly Asp Asn Ser Thr Ser Ala Gln Gly Asn 
    290                 295                 300                 


Tyr Leu Glu Ala Ile Asn Leu Ser Phe Asn Val Phe Asp Lys His Tyr 
305                 310                 315                 320 


Ile Asn Arg Asn Phe Asp Arg Thr Gly Gln Met Ser Val Val Ile Thr 
                325                 330                 335     


Pro Gly Val Gly Val Phe Glu Val Asp Arg Leu Leu Met Ile Leu Thr 
            340                 345                 350         


Lys Gln Arg Met Ile Asp Asn Gly Ile Gly Val Asp Leu Val Cys Met 
        355                 360                 365             


Gly Glu Gln Pro Leu His Ala Val Pro Leu Phe Lys Leu His Asn Arg 
    370                 375                 380                 


Ser Ala Pro Arg Asp Ser Arg Leu Gly Asp Asp Tyr Asn Ile Pro His 
385                 390                 395                 400 


Trp Ile Asn His Ser Phe Tyr Thr Ser Lys Ser Gln Leu Phe Cys Asn 
                405                 410                 415     


Ser Phe Thr Pro Arg Ile Lys Leu Ala Gly Lys Lys Pro Ala Ser Glu 
            420                 425                 430         


Lys Ala Lys Asn Gly Arg Asp Thr Ser Leu Gly Ser Pro Lys Glu Ser 
        435                 440                 445             


Glu Asn Ala Leu Pro Ile Gln Val Asp Tyr Asp Ala Tyr Asp Ala Gln 
    450                 455                 460                 


Val Phe Arg Leu Pro Gly Pro Ser Arg Ala Gln Cys Leu Thr Thr Cys 
465                 470                 475                 480 


Arg Ser Val Arg Glu Arg Glu Ser His Ser Arg Lys Ser Ala Ser Ser 
                485                 490                 495     


Cys Asp Val Ser Ser Ser Pro Ser Leu Pro Ser Arg Thr Leu Pro Thr 
            500                 505                 510         


Glu Glu Val Arg Ser Gln Ala Ser Asp Asp Ser Ser Leu Gly Lys Ser 
        515                 520                 525             


Ala Asn Ile Leu Met Ile Pro His Pro His Leu His Gln Tyr Glu Val 
    530                 535                 540                 


Ser Ser Ser Leu Gly Tyr Thr Ser Thr Arg Asp Val Leu Glu Asn Met 
545                 550                 555                 560 


Met Glu Pro Pro Gln Arg Asp Ser Ser Ala Pro Gly Arg Phe His Val 
                565                 570                 575     


Gly Ser Ala Glu Ser Met Leu His Val Arg Pro Gly Gly Tyr Thr Pro 
            580                 585                 590         


Gln Arg Ala Leu Ile Asn Pro Phe Ala Pro Ser Arg Met Pro Met Lys 
        595                 600                 605             


Leu Thr Ser Asn Arg Arg Arg Trp Met His Thr Phe Pro Val Gly Pro 
    610                 615                 620                 


Ser Gly Glu Ala Ile Gln Ile His His Gln Thr Arg Gln Asn Met Ala 
625                 630                 635                 640 


Glu Leu Gln Gly Ser Gly Gln Arg Asp Pro Thr His Ser Ser Ala Glu 
                645                 650                 655     


Leu Leu Glu Leu Ala Tyr His Glu Ala Ala Gly Arg His Ser Asn Ser 
            660                 665                 670         


Arg Gln Pro Gly Asp Gly Met Ser Phe Leu Asn Phe Ser Gly Thr Glu 
        675                 680                 685             


Glu Leu Ser Val Gly Leu Leu Ser Asn Ser Gly Ala Gly Met Asn Pro 
    690                 695                 700                 


Arg Thr Gln Asn Lys Asp Ser Leu Glu Asp Ser Val Ser Thr Ser Pro 
705                 710                 715                 720 


Asp Pro Ile Leu Thr Leu Ser Ala Pro Pro Val Val Pro Gly Phe Cys 
                725                 730                 735     


Cys Thr Val Gly Val Asp Trp Lys Ser Leu Thr Thr Pro Ala Cys Leu 
            740                 745                 750         


Pro Leu Thr Thr Asp Tyr Phe Pro Asp Arg Gln Gly Leu Gln Asn Asp 
        755                 760                 765             


Tyr Thr Glu Gly Cys Tyr Asp Leu Leu Pro Glu Ala Asp Ile Asp Arg 
    770                 775                 780                 


Arg Asp Glu Asp Gly Val Gln Met Thr Ala Gln Gln Val Phe Glu Glu 
785                 790                 795                 800 


Phe Ile Cys Gln Arg Leu Met Gln Gly Tyr Gln Ile Ile Val Gln Pro 
                805                 810                 815     


Lys Thr Gln Lys Pro Asn Pro Ala Val Pro Pro Pro Leu Ser Ser Ser 
            820                 825                 830         


Pro Leu Tyr Ser Arg Gly Leu Val Ser Arg Asn Arg Pro Glu Glu Glu 
        835                 840                 845             


Asp Gln Tyr Trp Leu Ser Met Gly Arg Thr Phe His Lys Val Thr Leu 
    850                 855                 860                 


Lys Asp Lys Met Ile Thr Val Thr Arg Tyr Leu Pro Lys Tyr Pro Tyr 
865                 870                 875                 880 


Glu Ser Ala Gln Ile His Tyr Thr Tyr Ser Leu Cys Pro Ser His Ser 
                885                 890                 895     


Asp Ser Glu Phe Val Ser Cys Trp Val Glu Phe Ser His Glu Arg Leu 
            900                 905                 910         


Glu Glu Tyr Lys Trp Asn Tyr Leu Asp Gln Tyr Ile Cys Ser Ala Gly 
        915                 920                 925             


Ser Glu Asp Phe Ser Leu Ile Glu Ser Leu Lys Phe Trp Arg Thr Arg 
    930                 935                 940                 


Phe Leu Leu Leu Pro Ala Cys Val Thr Ala Thr Lys Arg Ile Thr Glu 
945                 950                 955                 960 


Gly Glu Ala His Cys Asp Ile Tyr Gly Asp Arg Pro Arg Ala Asp Glu 
                965                 970                 975     


Asp Glu Trp Gln Leu Leu Asp Gly Phe Val Arg Phe Val Glu Gly Leu 
            980                 985                 990         


Asn Arg Ile Arg Arg Arg His Arg  Ser Asp Arg Met Met  Arg Lys Gly 
        995                 1000                 1005             


Thr Ala  Met Lys Gly Leu Gln  Met Thr Gly Pro Ile  Ser Thr His 
    1010                 1015                 1020             


Ser Leu  Glu Ser Thr Ala Pro  Pro Val Gly Lys Lys  Gly Thr Ser 
    1025                 1030                 1035             


Ala Leu  Ser Ala Leu Leu Glu  Met Glu Ala Ser Gln  Lys Cys Leu 
    1040                 1045                 1050             


Gly Glu  Gln Gln Ala Ala Val  His Gly Gly Lys Ser  Ser Ala Gln 
    1055                 1060                 1065             


Ser Ala  Glu Ser Ser Ser Val  Ala Met Thr Pro Thr  Tyr Met Asp 
    1070                 1075                 1080             


Ser Pro  Arg Lys Asp Gly Ala  Phe Phe Met Glu Phe  Val Arg Ser 
    1085                 1090                 1095             


Pro Arg  Thr Ala Ser Ser Ala  Phe Tyr Pro Gln Val  Ser Val Asp 
    1100                 1105                 1110             


Gln Thr  Ala Thr Pro Met Leu  Asp Gly Thr Ser Leu  Gly Ile Cys 
    1115                 1120                 1125             


Thr Gly  Gln Ser Met Asp Arg  Gly Asn Ser Gln Thr  Phe Gly Asn 
    1130                 1135                 1140             


Ser Gln  Asn Ile Gly Glu Gln  Gly Tyr Ser Ser Thr  Asn Ser Ser 
    1145                 1150                 1155             


Asp Ser  Ser Ser Gln Gln Leu  Val Ala Ser Ser Leu  Thr Ser Ser 
    1160                 1165                 1170             


Ser Thr  Leu Thr Glu Ile Leu  Glu Ala Met Lys His  Pro Ser Thr 
    1175                 1180                 1185             


Gly Val  Gln Leu Leu Ser Glu  Gln Lys Gly Leu Ser  Pro Tyr Cys 
    1190                 1195                 1200             


Phe Ile  Ser Ala Glu Val Val  His Trp Leu Val Asn  His Val Glu 
    1205                 1210                 1215             


Gly Ile  Gln Thr Gln Ala Met  Ala Ile Asp Ile Met  Gln Lys Met 
    1220                 1225                 1230             


Leu Glu  Glu Gln Leu Ile Thr  His Ala Ser Gly Glu  Ala Trp Arg 
    1235                 1240                 1245             


Thr Phe  Ile Tyr Gly Phe Tyr  Phe Tyr Lys Ile Val  Thr Asp Lys 
    1250                 1255                 1260             


Glu Pro  Asp Arg Val Ala Met  Gln Gln Pro Ala Thr  Thr Trp His 
    1265                 1270                 1275             


Thr Ala  Gly Val Asp Asp Phe  Ala Ser Phe Gln Arg  Lys Trp Phe 
    1280                 1285                 1290             


Glu Val  Ala Phe Val Ala Glu  Glu Leu Val His Ser  Glu Ile Pro 
    1295                 1300                 1305             


Ala Phe  Leu Leu Pro Trp Leu  Pro Ser Arg Pro Ala  Ser Tyr Ala 
    1310                 1315                 1320             


Ser Arg  His Ser Ser Phe Ser  Arg Ser Phe Gly Gly  Arg Ser Gln 
    1325                 1330                 1335             


Ala Ala  Ala Leu Leu Ala Ala  Thr Val Pro Glu Gln  Arg Thr Val 
    1340                 1345                 1350             


Thr Leu  Asp Val Asp Val Asn  Asn Arg Thr Asp Arg  Leu Glu Trp 
    1355                 1360                 1365             


Cys Ser  Cys Tyr Tyr His Gly  Asn Phe Ser Leu Asn  Ala Ala Phe 
    1370                 1375                 1380             


Glu Ile  Lys Leu His Trp Met  Ala Val Thr Ala Ala  Val Leu Phe 
    1385                 1390                 1395             


Glu Met  Val Gln Gly Trp His  Arg Lys Ala Thr Ser  Cys Gly Phe 
    1400                 1405                 1410             


Leu Leu  Val Pro Val Leu Glu  Gly Pro Phe Ala Leu  Pro Ser Tyr 
    1415                 1420                 1425             


Leu Tyr  Gly Asp Pro Leu Arg  Ala Gln Leu Phe Ile  Pro Leu Asn 
    1430                 1435                 1440             


Ile Ser  Cys Leu Leu Lys Glu  Gly Ser Glu His Leu  Phe Asp Ser 
    1445                 1450                 1455             


Phe Glu  Pro Glu Thr Tyr Trp  Asp Arg Met His Leu  Phe Gln Glu 
    1460                 1465                 1470             


Ala Ile  Ala His Arg Phe Gly  Phe Val Gln Asp Lys  Tyr Ser Ala 
    1475                 1480                 1485             


Ser Ala  Phe Asn Phe Pro Ala  Glu Asn Lys Pro Gln  Tyr Ile His 
    1490                 1495                 1500             


Val Thr  Gly Thr Val Phe Leu  Gln Leu Pro Tyr Ser  Lys Arg Lys 
    1505                 1510                 1515             


Phe Ser  Gly Gln Gln Arg Arg  Arg Arg Asn Ser Thr  Ser Ser Thr 
    1520                 1525                 1530             


Asn Gln  Asn Met Phe Cys Glu  Glu Arg Val Gly Tyr  Asn Trp Ala 
    1535                 1540                 1545             


Tyr Asn  Thr Met Leu Thr Lys  Thr Trp Arg Ser Ser  Ala Thr Gly 
    1550                 1555                 1560             


Asp Glu  Lys Phe Ala Asp Arg  Leu Leu Lys Asp Phe  Thr Asp Phe 
    1565                 1570                 1575             


Cys Ile  Asn Arg Asp Asn Arg  Leu Val Thr Phe Trp  Thr Ser Cys 
    1580                 1585                 1590             


Leu Glu  Lys Met His Ala Ser  Ala Pro 
    1595                 1600         


<210>  19
<211>  5551
<212>  DNA
<213>  Homo sapiens

<400>  19
ctagtaggcg cttcaggctt aggggcggaa cagcgcgggc cgcgcgggcg taggcggggt       60

atctggagga ggcgcaggga acctggagag ggtccagccc tcagtgcccc ggccagaggc      120

gggaaggggc tctagagctt cgggaggcaa gatgacttct ctgccccaag cttggaacag      180

ctaaagggaa aaacagtgca agatgagaac aacaaaggtc tacaaactcg tcatccacaa      240

gaagggcttt gggggcagtg atgatgagct agttgtgaac cccaaagtgt tccctcacat      300

caagcttgga gacattgtag agattgcaca ccccaacgat gaatacagcc ctctgctttt      360

gcaggtcaag tctcttaagg aagatttaca gaaggaaact atcagtgtgg accagactgt      420

gactcaagtg ttccggctga gaccttatca ggatgtctat gttaatgtcg tagaccctaa      480

ggatgtgacc cttgacctag tggaattaac ttttaaggat cagtatattg gccgtgggga      540

tatgtggcga ctaaagaaaa gtttggtcag cacatgtgcc tatatcaccc agaaggtgga      600

gtttgctggc atcagagcac aggctggtga actgtgggtt aagaatgaga aggtcatgtg      660

tggctacatc agtgaagata ccagggtggt gtttcgttct acgtcggcta tggtttacat      720

atttattcag atgagctgtg aaatgtggga ttttgatatt tatggggatt tgtattttga      780

gaaagctgtg aatggtttcc ttgctgatct atttaccaag tggaaggaga agaactgtag      840

tcatgaagtg acagtggtcc tgttttctag aactttctat gatgcaaaat ctgttgatga      900

atttcctgaa ataaaccgag cctcaattcg acaggatcac aaggggagat tctatgaaga      960

cttttacaaa gtggtggtgc agaatgagag aagagaagaa tggacttcac ttctcgtaac     1020

cattaaaaaa ctcttcatcc agtatccagt gttggtgcga ctggaacagg cagagggctt     1080

tcctcaagga gataattcta cctcagcaca aggaaactac ctggaggcca tcaatctgtc     1140

attcaatgtg tttgataagc actacatcaa ccgcaacttt gaccgaactg ggcagatgtc     1200

agtggtgatc acgcccgggg tgggtgtctt tgaagtggac cgcctactca tgatcctgac     1260

caagcagcgg atgatagata atggaattgg tgtggatttg gtgtgcatgg gagagcaacc     1320

gttacatgct gtcccattgt tcaagctcca taatcggagt gctccccgtg attctcgtct     1380

gggcgatgac tataatatcc ctcactggat aaaccacagt ttctacacat ccaaaagcca     1440

gctcttttgt aatagtttca ccccacgaat aaaactggca ggaaagaagc ccgcctctga     1500

gaaagcaaaa aatggccgtg atacatctct cgggagtcca aaagaatctg agaacgccct     1560

tcccatccaa gtagattatg acgcctatga cgctcaagtg ttcaggctgc ccggcccatc     1620

ccgggcccag tgcctcacca cctgcagatc tgtgcgagag cgagagagtc acagtcgaaa     1680

gagtgccagc tcctgtgatg tttcatccag cccttcccta ccaagccgca cactgcccac     1740

tgaggaagtg aggagccagg cttctgacga cagctcccta ggcaagagtg ccaacatcct     1800

gatgatccca cacccccacc tgcaccagta tgaagtcagc agctccttgg gatacaccag     1860

cactcgagat gtcctggaga acatgatgga gccaccacag cgagactcca gtgcaccagg     1920

gaggtttcac gttggcagtg cagaatccat gctgcatgtt cgacctggtg gatacacgcc     1980

ccagagagca ctgattaacc ccttcgctcc ctctcggatg cccatgaagc ttacgtccaa     2040

cagaaggcgc tggatgcaca cttttcctgt ggggccatcc ggagaagcca tccagatcca     2100

ccaccagacc cgacagaata tggcggagct acaaggcagc gggcagaggg atccaactca     2160

ctcctctgca gagctgctgg agttagcata tcatgaagct gctggaaggc acagcaattc     2220

ccgccagcct ggtgacggca tgtccttctt gaacttcagt ggaacagagg agctttctgt     2280

cggcctgctt agcaacagtg gtgcaggtat gaatcctagg acccagaata aggattctct     2340

agaggacagt gtttctacct ctccagaccc aattctgaca ctgtctgctc cccctgtagt     2400

gccaggcttc tgttgcacag ttggagtgga ctggaagtct ctcactactc cggcgtgcct     2460

cccccttacc accgactact tccctgaccg ccagggcctg cagaatgact acacagaggg     2520

ctgttatgat ctccttccag aagcagacat cgacaggagg gacgaagatg gtgtgcagat     2580

gacagcccag caggtatttg aagagtttat ttgccaacgt ctcatgcagg gctaccaaat     2640

catagtgcag cccaagacac agaaacccaa tcctgctgtc ccgcccccgc tgagcagtag     2700

cccactctat agccgaggcc ttgtgtcccg aaaccgccct gaggaggagg accagtattg     2760

gctgagtatg ggcagaacgt tccacaaagt gacgctgaag gataagatga tcacagtgac     2820

gcgatacctt cccaagtatc cttatgaatc tgcccagatc cactacacct acagcctctg     2880

tccttcccac tcagactcag agttcgtctc ctgctgggtg gaattctccc acgaacggct     2940

ggaggagtac aagtggaatt acttagatca gtatatctgt tctgccggct ctgaagactt     3000

cagcttaatt gagtccctga agttctggag gacccgcttc ctgctgctgc cagcctgtgt     3060

caccgccacc aagcgcatca cggaggggga ggcccactgc gacatctatg gggacaggcc     3120

ccgtgcagac gaggacgagt ggcaactcct ggatggtttt gtccgctttg tggagggctt     3180

gaatcgcatt cgcaggcggc atcgctcgga tcgcatgatg cggaaaggga ccgccatgaa     3240

aggcttgcag atgactgggc ccatttccac gcattctctg gagtcaactg cacccccagt     3300

ggggaagaag ggaacctcag ctctctctgc cctgttggag atggaggcca gtcagaagtg     3360

cctgggagaa cagcaggcag ctgtgcatgg tgggaagagc tccgcccagt cagccgagag     3420

cagcagcgtt gccatgactc ccacctacat ggacagccca cgaaaggacg gggccttctt     3480

tatggagttt gtccgcagcc cacgcacagc attgtccgcc ttctaccctc aggtatctgt     3540

ggaccaaaca gccactccta tgttggacgg caccagtttg ggcatatgca caggccaatc     3600

catggacaga ggcaacagcc agacctttgg gaactcccag aacataggag aacagggcta     3660

ctcctccaca aactccagtg acagcagctc tcagcagctg gtggcaagct ccttgacctc     3720

atcctctacc ctgacagaga tcctggaagc catgaagcac ccctcgacag gagtccagct     3780

gctctctgaa cagaagggcc tctcaccgta ctgcttcatc agcgcggagg tggtacactg     3840

gttggtgaac cacgtggagg ggatccagac acaggcgatg gccattgaca tcatgcagaa     3900

aatgctggaa gagcagctca tcacacatgc atctggcgaa gcctggcgga ccttcatcta     3960

cggcttctat ttctacaaga tagtaacgga caaagagccc gaccgagtgg ccatgcagca     4020

gcccgccacc acctggcaca cagcaggagt ggacgacttc gccagcttcc agcgcaagtg     4080

gtttgaggtg gcctttgtgg cagaagagct cgtgcactct gagattcctg cctttctcct     4140

gccctggctg cctagccggc cagcctccta tgcaagtagg cacagctcct ttagccgaag     4200

ttttggagga cggagccagg cggcagcact tttagctgcc actgtcccag agcagaggac     4260

tgtgaccctg gatgttgacg tgaacaaccg cacagaccgg ctggagtggt gcagctgtta     4320

ttaccatggc aacttttctc tgaatgcagc ctttgagatc aagctgcact ggatggcggt     4380

gaccgcagca gtactcttcg agatggtcca aggttggcat cggaaagcca cctcctgtgg     4440

cttcttgtta gtcccagttt tggaggggcc ttttgcactg cccagttacc tgtatggcga     4500

cccccttcgt gcccagctct tcatcccact caacatcagc tgcttgctca aggagggcag     4560

cgagcacctg tttgatagct ttgaacccga aacgtactgg gatcgaatgc acctcttcca     4620

ggaagccatt gcacacaggt ttgggtttgt acaagataaa tattctgcct ctgcttttaa     4680

cttccctgct gagaacaagc ctcagtatat ccacgttaca ggaacagtgt ttctgcagct     4740

gccctactcc aagcgcaagt tctcagggca gcagcggcgg cggcggaact ccaccagctc     4800

caccaaccag aacatgttct gcgaggagcg ggtcggctac aactgggcct acaacaccat     4860

gctcaccaaa acatggcgct ccagcgccac aggggatgaa aagtttgctg atcggctgct     4920

gaaggacttc acggacttct gcatcaaccg tgacaaccgg ctggtcacgt tctggacaag     4980

ttgcctggag aagatgcatg ccagtgcccc gtgaggccag gctgcacctg tgctggggga     5040

aggtgggtga gccactgccc tcaaacccgg ggcggaggat tccaggcagg ctctaggagt     5100

caggtgtccg tttgctgcta tcagtgagtg ggggccattg ttttttgttt gtttgtttgt     5160

ttgtttgttt gtttttggcc cccacgacaa gtcttctact ctagaagaaa gactttggaa     5220

gcagctgctg ctgctgccac cactcctgtc agcaagtgct cagagcaggt gggaggcaca     5280

gattgtccgt gggagggctc cagtgtctgg gaagagggca ggcggccccc atgaatgtcc     5340

tcggaagggg gtggctcctg gtagcatcct tttccttcac catctatggg atattagggg     5400

cagaatctgc cacttcttgc ccaggagtgt gcacagatgt aagataattt tgtgaaataa     5460

tgtaccatag actctcacca actgtatata cctgtacata tcagaagcaa ataaagagct     5520

ccacgtgcat catttctttc cccacccagt t                                    5551


<210>  20
<211>  1603
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Arg Thr Thr Lys Val Tyr Lys Leu Val Ile His Lys Lys Gly Phe 
1               5                   10                  15      


Gly Gly Ser Asp Asp Glu Leu Val Val Asn Pro Lys Val Phe Pro His 
            20                  25                  30          


Ile Lys Leu Gly Asp Ile Val Glu Ile Ala His Pro Asn Asp Glu Tyr 
        35                  40                  45              


Ser Pro Leu Leu Leu Gln Val Lys Ser Leu Lys Glu Asp Leu Gln Lys 
    50                  55                  60                  


Glu Thr Ile Ser Val Asp Gln Thr Val Thr Gln Val Phe Arg Leu Arg 
65                  70                  75                  80  


Pro Tyr Gln Asp Val Tyr Val Asn Val Val Asp Pro Lys Asp Val Thr 
                85                  90                  95      


Leu Asp Leu Val Glu Leu Thr Phe Lys Asp Gln Tyr Ile Gly Arg Gly 
            100                 105                 110         


Asp Met Trp Arg Leu Lys Lys Ser Leu Val Ser Thr Cys Ala Tyr Ile 
        115                 120                 125             


Thr Gln Lys Val Glu Phe Ala Gly Ile Arg Ala Gln Ala Gly Glu Leu 
    130                 135                 140                 


Trp Val Lys Asn Glu Lys Val Met Cys Gly Tyr Ile Ser Glu Asp Thr 
145                 150                 155                 160 


Arg Val Val Phe Arg Ser Thr Ser Ala Met Val Tyr Ile Phe Ile Gln 
                165                 170                 175     


Met Ser Cys Glu Met Trp Asp Phe Asp Ile Tyr Gly Asp Leu Tyr Phe 
            180                 185                 190         


Glu Lys Ala Val Asn Gly Phe Leu Ala Asp Leu Phe Thr Lys Trp Lys 
        195                 200                 205             


Glu Lys Asn Cys Ser His Glu Val Thr Val Val Leu Phe Ser Arg Thr 
    210                 215                 220                 


Phe Tyr Asp Ala Lys Ser Val Asp Glu Phe Pro Glu Ile Asn Arg Ala 
225                 230                 235                 240 


Ser Ile Arg Gln Asp His Lys Gly Arg Phe Tyr Glu Asp Phe Tyr Lys 
                245                 250                 255     


Val Val Val Gln Asn Glu Arg Arg Glu Glu Trp Thr Ser Leu Leu Val 
            260                 265                 270         


Thr Ile Lys Lys Leu Phe Ile Gln Tyr Pro Val Leu Val Arg Leu Glu 
        275                 280                 285             


Gln Ala Glu Gly Phe Pro Gln Gly Asp Asn Ser Thr Ser Ala Gln Gly 
    290                 295                 300                 


Asn Tyr Leu Glu Ala Ile Asn Leu Ser Phe Asn Val Phe Asp Lys His 
305                 310                 315                 320 


Tyr Ile Asn Arg Asn Phe Asp Arg Thr Gly Gln Met Ser Val Val Ile 
                325                 330                 335     


Thr Pro Gly Val Gly Val Phe Glu Val Asp Arg Leu Leu Met Ile Leu 
            340                 345                 350         


Thr Lys Gln Arg Met Ile Asp Asn Gly Ile Gly Val Asp Leu Val Cys 
        355                 360                 365             


Met Gly Glu Gln Pro Leu His Ala Val Pro Leu Phe Lys Leu His Asn 
    370                 375                 380                 


Arg Ser Ala Pro Arg Asp Ser Arg Leu Gly Asp Asp Tyr Asn Ile Pro 
385                 390                 395                 400 


His Trp Ile Asn His Ser Phe Tyr Thr Ser Lys Ser Gln Leu Phe Cys 
                405                 410                 415     


Asn Ser Phe Thr Pro Arg Ile Lys Leu Ala Gly Lys Lys Pro Ala Ser 
            420                 425                 430         


Glu Lys Ala Lys Asn Gly Arg Asp Thr Ser Leu Gly Ser Pro Lys Glu 
        435                 440                 445             


Ser Glu Asn Ala Leu Pro Ile Gln Val Asp Tyr Asp Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Val Phe Arg Leu Pro Gly Pro Ser Arg Ala Gln Cys Leu Thr Thr 
465                 470                 475                 480 


Cys Arg Ser Val Arg Glu Arg Glu Ser His Ser Arg Lys Ser Ala Ser 
                485                 490                 495     


Ser Cys Asp Val Ser Ser Ser Pro Ser Leu Pro Ser Arg Thr Leu Pro 
            500                 505                 510         


Thr Glu Glu Val Arg Ser Gln Ala Ser Asp Asp Ser Ser Leu Gly Lys 
        515                 520                 525             


Ser Ala Asn Ile Leu Met Ile Pro His Pro His Leu His Gln Tyr Glu 
    530                 535                 540                 


Val Ser Ser Ser Leu Gly Tyr Thr Ser Thr Arg Asp Val Leu Glu Asn 
545                 550                 555                 560 


Met Met Glu Pro Pro Gln Arg Asp Ser Ser Ala Pro Gly Arg Phe His 
                565                 570                 575     


Val Gly Ser Ala Glu Ser Met Leu His Val Arg Pro Gly Gly Tyr Thr 
            580                 585                 590         


Pro Gln Arg Ala Leu Ile Asn Pro Phe Ala Pro Ser Arg Met Pro Met 
        595                 600                 605             


Lys Leu Thr Ser Asn Arg Arg Arg Trp Met His Thr Phe Pro Val Gly 
    610                 615                 620                 


Pro Ser Gly Glu Ala Ile Gln Ile His His Gln Thr Arg Gln Asn Met 
625                 630                 635                 640 


Ala Glu Leu Gln Gly Ser Gly Gln Arg Asp Pro Thr His Ser Ser Ala 
                645                 650                 655     


Glu Leu Leu Glu Leu Ala Tyr His Glu Ala Ala Gly Arg His Ser Asn 
            660                 665                 670         


Ser Arg Gln Pro Gly Asp Gly Met Ser Phe Leu Asn Phe Ser Gly Thr 
        675                 680                 685             


Glu Glu Leu Ser Val Gly Leu Leu Ser Asn Ser Gly Ala Gly Met Asn 
    690                 695                 700                 


Pro Arg Thr Gln Asn Lys Asp Ser Leu Glu Asp Ser Val Ser Thr Ser 
705                 710                 715                 720 


Pro Asp Pro Ile Leu Thr Leu Ser Ala Pro Pro Val Val Pro Gly Phe 
                725                 730                 735     


Cys Cys Thr Val Gly Val Asp Trp Lys Ser Leu Thr Thr Pro Ala Cys 
            740                 745                 750         


Leu Pro Leu Thr Thr Asp Tyr Phe Pro Asp Arg Gln Gly Leu Gln Asn 
        755                 760                 765             


Asp Tyr Thr Glu Gly Cys Tyr Asp Leu Leu Pro Glu Ala Asp Ile Asp 
    770                 775                 780                 


Arg Arg Asp Glu Asp Gly Val Gln Met Thr Ala Gln Gln Val Phe Glu 
785                 790                 795                 800 


Glu Phe Ile Cys Gln Arg Leu Met Gln Gly Tyr Gln Ile Ile Val Gln 
                805                 810                 815     


Pro Lys Thr Gln Lys Pro Asn Pro Ala Val Pro Pro Pro Leu Ser Ser 
            820                 825                 830         


Ser Pro Leu Tyr Ser Arg Gly Leu Val Ser Arg Asn Arg Pro Glu Glu 
        835                 840                 845             


Glu Asp Gln Tyr Trp Leu Ser Met Gly Arg Thr Phe His Lys Val Thr 
    850                 855                 860                 


Leu Lys Asp Lys Met Ile Thr Val Thr Arg Tyr Leu Pro Lys Tyr Pro 
865                 870                 875                 880 


Tyr Glu Ser Ala Gln Ile His Tyr Thr Tyr Ser Leu Cys Pro Ser His 
                885                 890                 895     


Ser Asp Ser Glu Phe Val Ser Cys Trp Val Glu Phe Ser His Glu Arg 
            900                 905                 910         


Leu Glu Glu Tyr Lys Trp Asn Tyr Leu Asp Gln Tyr Ile Cys Ser Ala 
        915                 920                 925             


Gly Ser Glu Asp Phe Ser Leu Ile Glu Ser Leu Lys Phe Trp Arg Thr 
    930                 935                 940                 


Arg Phe Leu Leu Leu Pro Ala Cys Val Thr Ala Thr Lys Arg Ile Thr 
945                 950                 955                 960 


Glu Gly Glu Ala His Cys Asp Ile Tyr Gly Asp Arg Pro Arg Ala Asp 
                965                 970                 975     


Glu Asp Glu Trp Gln Leu Leu Asp Gly Phe Val Arg Phe Val Glu Gly 
            980                 985                 990         


Leu Asn Arg Ile Arg Arg Arg His  Arg Ser Asp Arg Met  Met Arg Lys 
        995                 1000                 1005             


Gly Thr  Ala Met Lys Gly Leu  Gln Met Thr Gly Pro  Ile Ser Thr 
    1010                 1015                 1020             


His Ser  Leu Glu Ser Thr Ala  Pro Pro Val Gly Lys  Lys Gly Thr 
    1025                 1030                 1035             


Ser Ala  Leu Ser Ala Leu Leu  Glu Met Glu Ala Ser  Gln Lys Cys 
    1040                 1045                 1050             


Leu Gly  Glu Gln Gln Ala Ala  Val His Gly Gly Lys  Ser Ser Ala 
    1055                 1060                 1065             


Gln Ser  Ala Glu Ser Ser Ser  Val Ala Met Thr Pro  Thr Tyr Met 
    1070                 1075                 1080             


Asp Ser  Pro Arg Lys Asp Gly  Ala Phe Phe Met Glu  Phe Val Arg 
    1085                 1090                 1095             


Ser Pro  Arg Thr Ala Leu Ser  Ala Phe Tyr Pro Gln  Val Ser Val 
    1100                 1105                 1110             


Asp Gln  Thr Ala Thr Pro Met  Leu Asp Gly Thr Ser  Leu Gly Ile 
    1115                 1120                 1125             


Cys Thr  Gly Gln Ser Met Asp  Arg Gly Asn Ser Gln  Thr Phe Gly 
    1130                 1135                 1140             


Asn Ser  Gln Asn Ile Gly Glu  Gln Gly Tyr Ser Ser  Thr Asn Ser 
    1145                 1150                 1155             


Ser Asp  Ser Ser Ser Gln Gln  Leu Val Ala Ser Ser  Leu Thr Ser 
    1160                 1165                 1170             


Ser Ser  Thr Leu Thr Glu Ile  Leu Glu Ala Met Lys  His Pro Ser 
    1175                 1180                 1185             


Thr Gly  Val Gln Leu Leu Ser  Glu Gln Lys Gly Leu  Ser Pro Tyr 
    1190                 1195                 1200             


Cys Phe  Ile Ser Ala Glu Val  Val His Trp Leu Val  Asn His Val 
    1205                 1210                 1215             


Glu Gly  Ile Gln Thr Gln Ala  Met Ala Ile Asp Ile  Met Gln Lys 
    1220                 1225                 1230             


Met Leu  Glu Glu Gln Leu Ile  Thr His Ala Ser Gly  Glu Ala Trp 
    1235                 1240                 1245             


Arg Thr  Phe Ile Tyr Gly Phe  Tyr Phe Tyr Lys Ile  Val Thr Asp 
    1250                 1255                 1260             


Lys Glu  Pro Asp Arg Val Ala  Met Gln Gln Pro Ala  Thr Thr Trp 
    1265                 1270                 1275             


His Thr  Ala Gly Val Asp Asp  Phe Ala Ser Phe Gln  Arg Lys Trp 
    1280                 1285                 1290             


Phe Glu  Val Ala Phe Val Ala  Glu Glu Leu Val His  Ser Glu Ile 
    1295                 1300                 1305             


Pro Ala  Phe Leu Leu Pro Trp  Leu Pro Ser Arg Pro  Ala Ser Tyr 
    1310                 1315                 1320             


Ala Ser  Arg His Ser Ser Phe  Ser Arg Ser Phe Gly  Gly Arg Ser 
    1325                 1330                 1335             


Gln Ala  Ala Ala Leu Leu Ala  Ala Thr Val Pro Glu  Gln Arg Thr 
    1340                 1345                 1350             


Val Thr  Leu Asp Val Asp Val  Asn Asn Arg Thr Asp  Arg Leu Glu 
    1355                 1360                 1365             


Trp Cys  Ser Cys Tyr Tyr His  Gly Asn Phe Ser Leu  Asn Ala Ala 
    1370                 1375                 1380             


Phe Glu  Ile Lys Leu His Trp  Met Ala Val Thr Ala  Ala Val Leu 
    1385                 1390                 1395             


Phe Glu  Met Val Gln Gly Trp  His Arg Lys Ala Thr  Ser Cys Gly 
    1400                 1405                 1410             


Phe Leu  Leu Val Pro Val Leu  Glu Gly Pro Phe Ala  Leu Pro Ser 
    1415                 1420                 1425             


Tyr Leu  Tyr Gly Asp Pro Leu  Arg Ala Gln Leu Phe  Ile Pro Leu 
    1430                 1435                 1440             


Asn Ile  Ser Cys Leu Leu Lys  Glu Gly Ser Glu His  Leu Phe Asp 
    1445                 1450                 1455             


Ser Phe  Glu Pro Glu Thr Tyr  Trp Asp Arg Met His  Leu Phe Gln 
    1460                 1465                 1470             


Glu Ala  Ile Ala His Arg Phe  Gly Phe Val Gln Asp  Lys Tyr Ser 
    1475                 1480                 1485             


Ala Ser  Ala Phe Asn Phe Pro  Ala Glu Asn Lys Pro  Gln Tyr Ile 
    1490                 1495                 1500             


His Val  Thr Gly Thr Val Phe  Leu Gln Leu Pro Tyr  Ser Lys Arg 
    1505                 1510                 1515             


Lys Phe  Ser Gly Gln Gln Arg  Arg Arg Arg Asn Ser  Thr Ser Ser 
    1520                 1525                 1530             


Thr Asn  Gln Asn Met Phe Cys  Glu Glu Arg Val Gly  Tyr Asn Trp 
    1535                 1540                 1545             


Ala Tyr  Asn Thr Met Leu Thr  Lys Thr Trp Arg Ser  Ser Ala Thr 
    1550                 1555                 1560             


Gly Asp  Glu Lys Phe Ala Asp  Arg Leu Leu Lys Asp  Phe Thr Asp 
    1565                 1570                 1575             


Phe Cys  Ile Asn Arg Asp Asn  Arg Leu Val Thr Phe  Trp Thr Ser 
    1580                 1585                 1590             


Cys Leu  Glu Lys Met His Ala  Ser Ala Pro 
    1595                 1600             


<210>  21
<211>  5551
<212>  DNA
<213>  Homo sapiens

<400>  21
ctagtaggcg cttcaggctt aggggcggaa cagcgcgggc cgcgcgggcg taggcggggt       60

atctggagga ggcgcaggga acctggagag ggtccagccc tcagtgcccc ggccagaggc      120

gggaaggggc tctagagctt cgggaggcaa gatgacttct ctgccccaag cttggaacag      180

ctaaagggaa aaacagtgca agatgagaac aacaaaggtc tacaaactcg tcatccacaa      240

gaagggcttt gggggcagtg atgatgagct agttgtgaac cccaaagtgt tccctcacat      300

caagcttgga gacattgtag agattgcaca ccccaacgat gaatacagcc ctctgctttt      360

gcaggtcaag tctcttaagg aagatttaca gaaggaaact atcagtgtgg accagactgt      420

gactcaagtg ttccggctga gaccttatca ggatgtctat gttaatgtcg tagaccctaa      480

ggatgtgacc cttgacctag tggaattaac ttttaaggat cagtatattg gccgtgggga      540

tatgtggcga ctaaagaaaa gtttggtcag cacatgtgcc tatatcaccc agaaggtgga      600

gtttgctggc atcagagcac aggctggtga actgtgggtt aagaatgaga aggtcatgtg      660

tggctacatc agtgaagata ccagggtggt gtttcgttct acgtcggcta tggtttacat      720

atttattcag atgagctgtg aaatgtggga ttttgatatt tatggggatt tgtattttga      780

gaaagctgtg aatggtttcc ttgctgatct atttaccaag tggaaggaga agaactgtag      840

tcatgaagtg acagtggtcc tgttttctag aactttctat gatgcaaaat ctgttgatga      900

atttcctgaa ataaaccgag cctcaattcg acaggatcac aaggggagat tctatgaaga      960

cttttacaaa gtggtggtgc agaatgagag aagagaagaa tggacttcac ttctcgtaac     1020

cattaaaaaa ctcttcatcc agtatccagt gttggtgcga ctggaacagg cagagggctt     1080

tcctcaagga gataattcta cctcagcaca aggaaactac ctggaggcca tcaatctgtc     1140

attcaatgtg tttgataagc actacatcaa ccgcaacttt gaccgaactg ggcagatgtc     1200

agtggtgatc acgcccgggg tgggtgtctt tgaagtggac cgcctactca tgatcctgac     1260

caagcagcgg atgatagata atggaattgg tgtggatttg gtgtgcatgg gagagcaacc     1320

gttacatgct gtcccattgt tcaagctcca taatcggagt gctccccgtg attctcgtct     1380

gggcgatgac tataatatcc ctcactggat aaaccacagt ttctacacat ccaaaagcca     1440

gctcttttgt aatagtttca ccccacgaat aaaactggca ggaaagaagc ccgcctctga     1500

gaaagcaaaa aatggccgtg atacatctct cgggagtcca aaagaatctg agaacgccct     1560

tcccatccaa gtagattatg acgcctatga cgctcaagtg ttcaggctgc ccggcccatc     1620

ccgggcccag tgcctcacca cctgcagatc tgtgcgagag cgagagagtc acagtcgaaa     1680

gagtgccagc tcctgtgatg tttcatccag cccttcccta ccaagccgca cactgcccac     1740

tgaggaagtg aggagccagg cttctgacga cagctcccta ggcaagagtg ccaacatcct     1800

gatgatccca cacccccacc tgcaccagta tgaagtcagc agctccttgg gatacaccag     1860

cactcgagat gtcctggaga acatgatgga gccaccacag cgagactcca gtgcaccagg     1920

gaggtttcac gttggcagtg cagaatccat gctgcatgtt cgacctggtg gatacacgcc     1980

ccagagagca ctgattaacc ccttcgctcc ctctcggatg cccatgaagc ttacgtccaa     2040

cagaaggcgc tggatgcaca cttttcctgt ggggccatcc ggagaagcca tccagatcca     2100

ccaccagacc cgacagaata tggcggagct acaaggcagc gggcagaggg atccaactca     2160

ctcctctgca gagctgctgg agttagcata tcatgaagct gctggaaggc acagcaattc     2220

ccgccagcct ggtgacggca tgtccttctt gaacttcagt ggaacagagg agctttctgt     2280

cggcctgctt agcaacagtg gtgcaggtat gaatcctagg acccagaata aggattctct     2340

agaggacagt gtttctacct ctccagaccc aattctgaca ctgtctgctc cccctgtagt     2400

gccaggcttc tgttgcacag ttggagtgga ctggaagtct ctcactactc cggcgtgcct     2460

cccccttacc accgactact tccctgaccg ccagggcctg cagaatgact acacagaggg     2520

ctgttatgat ctccttccag aagcagacat cgacaggagg gacgaagatg gtgtgcagat     2580

gacagcccag caggtatttg aagagtttat ttgccaacgt ctcatgcagg gctaccaaat     2640

catagtgcag cccaagacac agaaacccaa tcctgctgtc ccgcccccgc tgagcagtag     2700

cccactctat agccgaggcc ttgtgtcccg aaaccgccct gaggaggagg accagtattg     2760

gctgagtatg ggcagaacgt tccacaaagt gacgctgaag gataagatga tcacagtgac     2820

gcgatacctt cccaagtatc cttatgaatc tgcccagatc cactacacct acagcctctg     2880

tccttcccac tcagactcag agttcgtctc ctgctgggtg gaattctccc acgaacggct     2940

ggaggagtac aagtggaatt acttagatca gtatatctgt tctgccggct ctgaagactt     3000

cagcttaatt gagtccctga agttctggag gacccgcttc ctgctgctgc cagcctgtgt     3060

caccgccacc aagcgcatca cggaggggga ggcccactgc gacatctatg gggacaggcc     3120

ccgtgcagac gaggacgagt ggcaactcct ggatggtttt gtccgctttg tggagggctt     3180

gaatcgcatt cgcaggcggc atcgctcgga tcgcatgatg cggaaaggga ccgccatgaa     3240

aggcttgcag atgactgggc ccatttccac gcattctctg gagtcaactg cacccccagt     3300

ggggaagaag ggaacctcag ctctctctgc cctgttggag atggaggcca gtcagaagtg     3360

cctgggagaa cagcaggcag ctgtgcatgg tgggaagagc tccgcccagt cagccgagcg     3420

cagcagcgtt gccatgactc ccacctacat ggacagccca cgaaaggacg gggccttctt     3480

tatggagttt gtccgcagcc cacgcacagc atcgtccgcc ttctaccctc aggtatctgt     3540

ggaccaaaca gccactccta tgttggacgg caccagtttg ggcatatgca caggccaatc     3600

catggacaga ggcaacagcc agacctttgg gaactcccag aacataggag aacagggcta     3660

ctcctccaca aactccagtg acagcagctc tcagcagctg gtggcaagct ccttgacctc     3720

atcctctacc ctgacagaga tcctggaagc catgaagcac ccctcgacag gagtccagct     3780

gctctctgaa cagaagggcc tctcaccgta ctgcttcatc agcgcggagg tggtacactg     3840

gttggtgaac cacgtggagg ggatccagac acaggcgatg gccattgaca tcatgcagaa     3900

aatgctggaa gagcagctca tcacacatgc atctggcgaa gcctggcgga ccttcatcta     3960

cggcttctat ttctacaaga tagtaacgga caaagagccc gaccgagtgg ccatgcagca     4020

gcccgccacc acctggcaca cagcaggagt ggacgacttc gccagcttcc agcgcaagtg     4080

gtttgaggtg gcctttgtgg cagaagagct cgtgcactct gagattcctg cctttctcct     4140

gccctggctg cctagccggc cagcctccta tgcaagtagg cacagctcct ttagccgaag     4200

ttttggagga cggagccagg cggcagcact tttagctgcc actgtcccag agcagaggac     4260

tgtgaccctg gatgttgacg tgaacaaccg cacagaccgg ctggagtggt gcagctgtta     4320

ttaccatggc aacttttctc tgaatgcagc ctttgagatc aagctgcact ggatggcggt     4380

gaccgcagca gtactcttcg agatggtcca aggttggcat cggaaagcca cctcctgtgg     4440

cttcttgtta gtcccagttt tggaggggcc ttttgcactg cccagttacc tgtatggcga     4500

cccccttcgt gcccagctct tcatcccact caacatcagc tgcttgctca aggagggcag     4560

cgagcacctg tttgatagct ttgaacccga aacgtactgg gatcgaatgc acctcttcca     4620

ggaagccatt gcacacaggt ttgggtttgt acaagataaa tattctgcct ctgcttttaa     4680

cttccctgct gagaacaagc ctcagtatat ccacgttaca ggaacagtgt ttctgcagct     4740

gccctactcc aagcgcaagt tctcagggca gcagcggcgg cggcggaact ccaccagctc     4800

caccaaccag aacatgttct gcgaggagcg ggtcggctac aactgggcct acaacaccat     4860

gctcaccaaa acatggcgct ccagcgccac aggggatgaa aagtttgctg atcggctgct     4920

gaaggacttc acggacttct gcatcaaccg tgacaaccgg ctggtcacgt tctggacaag     4980

ttgcctggag aagatgcatg ccagtgcccc gtgaggccag gctgcacctg tgctggggga     5040

aggtgggtga gccactgccc tcaaacccgg ggcggaggat tccaggcagg ctctaggagt     5100

caggtgtccg tttgctgcta tcagtgagtg ggggccattg ttttttgttt gtttgtttgt     5160

ttgtttgttt gtttttggcc cccacgacaa gtcttctact ctagaagaaa gactttggaa     5220

gcagctgctg ctgctgccac cactcctgtc agcaagtgct cagagcaggt gggaggcaca     5280

gattgtccgt gggagggctc cagtgtctgg gaagagggca ggcggccccc atgaatgtcc     5340

tcggaagggg gtggctcctg gtagcatcct tttccttcac catctatggg atattagggg     5400

cagaatctgc cacttcttgc ccaggagtgt gcacagatgt aagataattt tgtgaaataa     5460

tgtaccatag actctcacca actgtatata cctgtacata tcagaagcaa ataaagagct     5520

ccacgtgcat catttctttc cccacccagt t                                    5551


<210>  22
<211>  1603
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Arg Thr Thr Lys Val Tyr Lys Leu Val Ile His Lys Lys Gly Phe 
1               5                   10                  15      


Gly Gly Ser Asp Asp Glu Leu Val Val Asn Pro Lys Val Phe Pro His 
            20                  25                  30          


Ile Lys Leu Gly Asp Ile Val Glu Ile Ala His Pro Asn Asp Glu Tyr 
        35                  40                  45              


Ser Pro Leu Leu Leu Gln Val Lys Ser Leu Lys Glu Asp Leu Gln Lys 
    50                  55                  60                  


Glu Thr Ile Ser Val Asp Gln Thr Val Thr Gln Val Phe Arg Leu Arg 
65                  70                  75                  80  


Pro Tyr Gln Asp Val Tyr Val Asn Val Val Asp Pro Lys Asp Val Thr 
                85                  90                  95      


Leu Asp Leu Val Glu Leu Thr Phe Lys Asp Gln Tyr Ile Gly Arg Gly 
            100                 105                 110         


Asp Met Trp Arg Leu Lys Lys Ser Leu Val Ser Thr Cys Ala Tyr Ile 
        115                 120                 125             


Thr Gln Lys Val Glu Phe Ala Gly Ile Arg Ala Gln Ala Gly Glu Leu 
    130                 135                 140                 


Trp Val Lys Asn Glu Lys Val Met Cys Gly Tyr Ile Ser Glu Asp Thr 
145                 150                 155                 160 


Arg Val Val Phe Arg Ser Thr Ser Ala Met Val Tyr Ile Phe Ile Gln 
                165                 170                 175     


Met Ser Cys Glu Met Trp Asp Phe Asp Ile Tyr Gly Asp Leu Tyr Phe 
            180                 185                 190         


Glu Lys Ala Val Asn Gly Phe Leu Ala Asp Leu Phe Thr Lys Trp Lys 
        195                 200                 205             


Glu Lys Asn Cys Ser His Glu Val Thr Val Val Leu Phe Ser Arg Thr 
    210                 215                 220                 


Phe Tyr Asp Ala Lys Ser Val Asp Glu Phe Pro Glu Ile Asn Arg Ala 
225                 230                 235                 240 


Ser Ile Arg Gln Asp His Lys Gly Arg Phe Tyr Glu Asp Phe Tyr Lys 
                245                 250                 255     


Val Val Val Gln Asn Glu Arg Arg Glu Glu Trp Thr Ser Leu Leu Val 
            260                 265                 270         


Thr Ile Lys Lys Leu Phe Ile Gln Tyr Pro Val Leu Val Arg Leu Glu 
        275                 280                 285             


Gln Ala Glu Gly Phe Pro Gln Gly Asp Asn Ser Thr Ser Ala Gln Gly 
    290                 295                 300                 


Asn Tyr Leu Glu Ala Ile Asn Leu Ser Phe Asn Val Phe Asp Lys His 
305                 310                 315                 320 


Tyr Ile Asn Arg Asn Phe Asp Arg Thr Gly Gln Met Ser Val Val Ile 
                325                 330                 335     


Thr Pro Gly Val Gly Val Phe Glu Val Asp Arg Leu Leu Met Ile Leu 
            340                 345                 350         


Thr Lys Gln Arg Met Ile Asp Asn Gly Ile Gly Val Asp Leu Val Cys 
        355                 360                 365             


Met Gly Glu Gln Pro Leu His Ala Val Pro Leu Phe Lys Leu His Asn 
    370                 375                 380                 


Arg Ser Ala Pro Arg Asp Ser Arg Leu Gly Asp Asp Tyr Asn Ile Pro 
385                 390                 395                 400 


His Trp Ile Asn His Ser Phe Tyr Thr Ser Lys Ser Gln Leu Phe Cys 
                405                 410                 415     


Asn Ser Phe Thr Pro Arg Ile Lys Leu Ala Gly Lys Lys Pro Ala Ser 
            420                 425                 430         


Glu Lys Ala Lys Asn Gly Arg Asp Thr Ser Leu Gly Ser Pro Lys Glu 
        435                 440                 445             


Ser Glu Asn Ala Leu Pro Ile Gln Val Asp Tyr Asp Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Val Phe Arg Leu Pro Gly Pro Ser Arg Ala Gln Cys Leu Thr Thr 
465                 470                 475                 480 


Cys Arg Ser Val Arg Glu Arg Glu Ser His Ser Arg Lys Ser Ala Ser 
                485                 490                 495     


Ser Cys Asp Val Ser Ser Ser Pro Ser Leu Pro Ser Arg Thr Leu Pro 
            500                 505                 510         


Thr Glu Glu Val Arg Ser Gln Ala Ser Asp Asp Ser Ser Leu Gly Lys 
        515                 520                 525             


Ser Ala Asn Ile Leu Met Ile Pro His Pro His Leu His Gln Tyr Glu 
    530                 535                 540                 


Val Ser Ser Ser Leu Gly Tyr Thr Ser Thr Arg Asp Val Leu Glu Asn 
545                 550                 555                 560 


Met Met Glu Pro Pro Gln Arg Asp Ser Ser Ala Pro Gly Arg Phe His 
                565                 570                 575     


Val Gly Ser Ala Glu Ser Met Leu His Val Arg Pro Gly Gly Tyr Thr 
            580                 585                 590         


Pro Gln Arg Ala Leu Ile Asn Pro Phe Ala Pro Ser Arg Met Pro Met 
        595                 600                 605             


Lys Leu Thr Ser Asn Arg Arg Arg Trp Met His Thr Phe Pro Val Gly 
    610                 615                 620                 


Pro Ser Gly Glu Ala Ile Gln Ile His His Gln Thr Arg Gln Asn Met 
625                 630                 635                 640 


Ala Glu Leu Gln Gly Ser Gly Gln Arg Asp Pro Thr His Ser Ser Ala 
                645                 650                 655     


Glu Leu Leu Glu Leu Ala Tyr His Glu Ala Ala Gly Arg His Ser Asn 
            660                 665                 670         


Ser Arg Gln Pro Gly Asp Gly Met Ser Phe Leu Asn Phe Ser Gly Thr 
        675                 680                 685             


Glu Glu Leu Ser Val Gly Leu Leu Ser Asn Ser Gly Ala Gly Met Asn 
    690                 695                 700                 


Pro Arg Thr Gln Asn Lys Asp Ser Leu Glu Asp Ser Val Ser Thr Ser 
705                 710                 715                 720 


Pro Asp Pro Ile Leu Thr Leu Ser Ala Pro Pro Val Val Pro Gly Phe 
                725                 730                 735     


Cys Cys Thr Val Gly Val Asp Trp Lys Ser Leu Thr Thr Pro Ala Cys 
            740                 745                 750         


Leu Pro Leu Thr Thr Asp Tyr Phe Pro Asp Arg Gln Gly Leu Gln Asn 
        755                 760                 765             


Asp Tyr Thr Glu Gly Cys Tyr Asp Leu Leu Pro Glu Ala Asp Ile Asp 
    770                 775                 780                 


Arg Arg Asp Glu Asp Gly Val Gln Met Thr Ala Gln Gln Val Phe Glu 
785                 790                 795                 800 


Glu Phe Ile Cys Gln Arg Leu Met Gln Gly Tyr Gln Ile Ile Val Gln 
                805                 810                 815     


Pro Lys Thr Gln Lys Pro Asn Pro Ala Val Pro Pro Pro Leu Ser Ser 
            820                 825                 830         


Ser Pro Leu Tyr Ser Arg Gly Leu Val Ser Arg Asn Arg Pro Glu Glu 
        835                 840                 845             


Glu Asp Gln Tyr Trp Leu Ser Met Gly Arg Thr Phe His Lys Val Thr 
    850                 855                 860                 


Leu Lys Asp Lys Met Ile Thr Val Thr Arg Tyr Leu Pro Lys Tyr Pro 
865                 870                 875                 880 


Tyr Glu Ser Ala Gln Ile His Tyr Thr Tyr Ser Leu Cys Pro Ser His 
                885                 890                 895     


Ser Asp Ser Glu Phe Val Ser Cys Trp Val Glu Phe Ser His Glu Arg 
            900                 905                 910         


Leu Glu Glu Tyr Lys Trp Asn Tyr Leu Asp Gln Tyr Ile Cys Ser Ala 
        915                 920                 925             


Gly Ser Glu Asp Phe Ser Leu Ile Glu Ser Leu Lys Phe Trp Arg Thr 
    930                 935                 940                 


Arg Phe Leu Leu Leu Pro Ala Cys Val Thr Ala Thr Lys Arg Ile Thr 
945                 950                 955                 960 


Glu Gly Glu Ala His Cys Asp Ile Tyr Gly Asp Arg Pro Arg Ala Asp 
                965                 970                 975     


Glu Asp Glu Trp Gln Leu Leu Asp Gly Phe Val Arg Phe Val Glu Gly 
            980                 985                 990         


Leu Asn Arg Ile Arg Arg Arg His  Arg Ser Asp Arg Met  Met Arg Lys 
        995                 1000                 1005             


Gly Thr  Ala Met Lys Gly Leu  Gln Met Thr Gly Pro  Ile Ser Thr 
    1010                 1015                 1020             


His Ser  Leu Glu Ser Thr Ala  Pro Pro Val Gly Lys  Lys Gly Thr 
    1025                 1030                 1035             


Ser Ala  Leu Ser Ala Leu Leu  Glu Met Glu Ala Ser  Gln Lys Cys 
    1040                 1045                 1050             


Leu Gly  Glu Gln Gln Ala Ala  Val His Gly Gly Lys  Ser Ser Ala 
    1055                 1060                 1065             


Gln Ser  Ala Glu Arg Ser Ser  Val Ala Met Thr Pro  Thr Tyr Met 
    1070                 1075                 1080             


Asp Ser  Pro Arg Lys Asp Gly  Ala Phe Phe Met Glu  Phe Val Arg 
    1085                 1090                 1095             


Ser Pro  Arg Thr Ala Ser Ser  Ala Phe Tyr Pro Gln  Val Ser Val 
    1100                 1105                 1110             


Asp Gln  Thr Ala Thr Pro Met  Leu Asp Gly Thr Ser  Leu Gly Ile 
    1115                 1120                 1125             


Cys Thr  Gly Gln Ser Met Asp  Arg Gly Asn Ser Gln  Thr Phe Gly 
    1130                 1135                 1140             


Asn Ser  Gln Asn Ile Gly Glu  Gln Gly Tyr Ser Ser  Thr Asn Ser 
    1145                 1150                 1155             


Ser Asp  Ser Ser Ser Gln Gln  Leu Val Ala Ser Ser  Leu Thr Ser 
    1160                 1165                 1170             


Ser Ser  Thr Leu Thr Glu Ile  Leu Glu Ala Met Lys  His Pro Ser 
    1175                 1180                 1185             


Thr Gly  Val Gln Leu Leu Ser  Glu Gln Lys Gly Leu  Ser Pro Tyr 
    1190                 1195                 1200             


Cys Phe  Ile Ser Ala Glu Val  Val His Trp Leu Val  Asn His Val 
    1205                 1210                 1215             


Glu Gly  Ile Gln Thr Gln Ala  Met Ala Ile Asp Ile  Met Gln Lys 
    1220                 1225                 1230             


Met Leu  Glu Glu Gln Leu Ile  Thr His Ala Ser Gly  Glu Ala Trp 
    1235                 1240                 1245             


Arg Thr  Phe Ile Tyr Gly Phe  Tyr Phe Tyr Lys Ile  Val Thr Asp 
    1250                 1255                 1260             


Lys Glu  Pro Asp Arg Val Ala  Met Gln Gln Pro Ala  Thr Thr Trp 
    1265                 1270                 1275             


His Thr  Ala Gly Val Asp Asp  Phe Ala Ser Phe Gln  Arg Lys Trp 
    1280                 1285                 1290             


Phe Glu  Val Ala Phe Val Ala  Glu Glu Leu Val His  Ser Glu Ile 
    1295                 1300                 1305             


Pro Ala  Phe Leu Leu Pro Trp  Leu Pro Ser Arg Pro  Ala Ser Tyr 
    1310                 1315                 1320             


Ala Ser  Arg His Ser Ser Phe  Ser Arg Ser Phe Gly  Gly Arg Ser 
    1325                 1330                 1335             


Gln Ala  Ala Ala Leu Leu Ala  Ala Thr Val Pro Glu  Gln Arg Thr 
    1340                 1345                 1350             


Val Thr  Leu Asp Val Asp Val  Asn Asn Arg Thr Asp  Arg Leu Glu 
    1355                 1360                 1365             


Trp Cys  Ser Cys Tyr Tyr His  Gly Asn Phe Ser Leu  Asn Ala Ala 
    1370                 1375                 1380             


Phe Glu  Ile Lys Leu His Trp  Met Ala Val Thr Ala  Ala Val Leu 
    1385                 1390                 1395             


Phe Glu  Met Val Gln Gly Trp  His Arg Lys Ala Thr  Ser Cys Gly 
    1400                 1405                 1410             


Phe Leu  Leu Val Pro Val Leu  Glu Gly Pro Phe Ala  Leu Pro Ser 
    1415                 1420                 1425             


Tyr Leu  Tyr Gly Asp Pro Leu  Arg Ala Gln Leu Phe  Ile Pro Leu 
    1430                 1435                 1440             


Asn Ile  Ser Cys Leu Leu Lys  Glu Gly Ser Glu His  Leu Phe Asp 
    1445                 1450                 1455             


Ser Phe  Glu Pro Glu Thr Tyr  Trp Asp Arg Met His  Leu Phe Gln 
    1460                 1465                 1470             


Glu Ala  Ile Ala His Arg Phe  Gly Phe Val Gln Asp  Lys Tyr Ser 
    1475                 1480                 1485             


Ala Ser  Ala Phe Asn Phe Pro  Ala Glu Asn Lys Pro  Gln Tyr Ile 
    1490                 1495                 1500             


His Val  Thr Gly Thr Val Phe  Leu Gln Leu Pro Tyr  Ser Lys Arg 
    1505                 1510                 1515             


Lys Phe  Ser Gly Gln Gln Arg  Arg Arg Arg Asn Ser  Thr Ser Ser 
    1520                 1525                 1530             


Thr Asn  Gln Asn Met Phe Cys  Glu Glu Arg Val Gly  Tyr Asn Trp 
    1535                 1540                 1545             


Ala Tyr  Asn Thr Met Leu Thr  Lys Thr Trp Arg Ser  Ser Ala Thr 
    1550                 1555                 1560             


Gly Asp  Glu Lys Phe Ala Asp  Arg Leu Leu Lys Asp  Phe Thr Asp 
    1565                 1570                 1575             


Phe Cys  Ile Asn Arg Asp Asn  Arg Leu Val Thr Phe  Trp Thr Ser 
    1580                 1585                 1590             


Cys Leu  Glu Lys Met His Ala  Ser Ala Pro 
    1595                 1600             


<210>  23
<211>  5551
<212>  DNA
<213>  Homo sapiens

<400>  23
ctagtaggcg cttcaggctt aggggcggaa cagcgcgggc cgcgcgggcg taggcggggt       60

atctggagga ggcgcaggga acctggagag ggtccagccc tcagtgcccc ggccagaggc      120

gggaaggggc tctagagctt cgggaggcaa gatgacttct ctgccccaag cttggaacag      180

ctaaagggaa aaacagtgca agatgagaac aacaaaggtc tacaaactcg tcatccacaa      240

gaagggcttt gggggcagtg atgatgagct agttgtgaac cccaaagtgt tccctcacat      300

caagcttgga gacattgtag agattgcaca ccccaacgat gaatacagcc ctctgctttt      360

gcaggtcaag tctcttaagg aagatttaca gaaggaaact atcagtgtgg accagactgt      420

gactcaagtg ttccggctga gaccttatca ggatgtctat gttaatgtcg tagaccctaa      480

ggatgtgacc cttgacctag tggaattaac ttttaaggat cagtatattg gccgtgggga      540

tatgtggcga ctaaagaaaa gtttggtcag cacatgtgcc tatatcaccc agaaggtgga      600

gtttgctggc atcagagcac aggctggtga actgtgggtt aagaatgaga aggtcatgtg      660

tggctacatc agtgaagata ccagggtggt gtttcgttct acgtcggcta tggtttacat      720

atttattcag atgagctgtg aaatgtggga ttttgatatt tatggggatt tgtattttga      780

gaaagctgtg aatggtttcc ttgctgatct atttaccaag tggaaggaga agaactgtag      840

tcatgaagtg acagtggtcc tgttttctag aactttctat gatgcaaaat ctgttgatga      900

atttcctgaa ataaaccgag cctcaattcg acaggatcac aaggggagat tctatgaaga      960

cttttacaaa gtggtggtgc agaatgagag aagagaagaa tggacttcac ttctcgtaac     1020

cattaaaaaa ctcttcatcc agtatccagt gttggtgcga ctggaacagg cagagggctt     1080

tcctcaagga gataattcta cctcagcaca aggaaactac ctggaggcca tcaatctgtc     1140

attcaatgtg tttgataagc actacatcaa ccgcaacttt gaccgaactg ggcagatgtc     1200

agtggtgatc acgcccgggg tgggtgtctt tgaagtggac cgcctactca tgatcctgac     1260

caagcagcgg atgatagata atggaattgg tgtggatttg gtgtgcatgg gagagcaacc     1320

gttacatgct gtcccattgt tcaagctcca taatcggagt gctccccgtg attctcgtct     1380

gggcgatgac tataatatcc ctcactggat aaaccacagt ttctacacat ccaaaagcca     1440

gctcttttgt aatagtttca ccccacgaat aaaactggca ggaaagaagc ccgcctctga     1500

gaaagcaaaa aatggccgtg atacatctct cgggagtcca aaagaatctg agaacgtcct     1560

tcccatccaa gtagattatg acgcctatga cgctcaagtg ttcaggctgc ccggcccatc     1620

ccgggcccag tgcctcacca cctgcagatc tgtgcgagag cgagagagtc acagtcgaaa     1680

gagtgccagc tcctgtgatg tttcatccag cccttcccta ccaagccgca cactgcccac     1740

tgaggaagtg aggagccagg cttctgacga cagctcccta ggcaagagtg ccaacatcct     1800

gatgatccca cacccccacc tgcaccagta tgaagtcagc agctccttgg gatacaccag     1860

cactcgagat gtcctggaga acatgatgga gccaccacag cgagactcca gtgcaccagg     1920

gaggtttcac gttggcagtg cagaatccat gctgcatgtt cgacctggtg gatacacgcc     1980

ccagagagca ctgattaacc ccttcgctcc ctctcggatg cccatgaagc ttacgtccaa     2040

cagaaggcgc tggatgcaca cttttcctgt ggggccatcc ggagaagcca tccagatcca     2100

ccaccagacc cgacagaata tggcggagct acaaggcagc gggcagaggg atccaactca     2160

ctcctctgca gagctgctgg agttagcata tcatgaagct gctggaaggc acagcaattc     2220

ccgccagcct ggtgacggca tgtccttctt gaacttcagt ggaacagagg agctttctgt     2280

cggcctgctt agcaacagtg gtgcaggtat gaatcctagg acccagaata aggattctct     2340

agaggacagt gtttctacct ctccagaccc aattctgaca ctgtctgctc cccctgtagt     2400

gccaggcttc tgttgcacag ttggagtgga ctggaagtct ctcactactc cggcgtgcct     2460

cccccttacc accgactact tccctgaccg ccagggcctg cagaatgact acacagaggg     2520

ctgttatgat ctccttccag aagcagacat cgacaggagg gacgaagatg gtgtgcagat     2580

gacagcccag caggtatttg aagagtttat ttgccaacgt ctcatgcagg gctaccaaat     2640

catagtgcag cccaagacac agaaacccaa tcctgctgtc ccgcccccgc tgagcagtag     2700

cccactctat agccgaggcc ttgtgtcccg aaaccgccct gaggaggagg accagtattg     2760

gctgagtatg ggcagaacgt tccacaaagt gacgctgaag gataagatga tcacagtgac     2820

gcgatacctt cccaagtatc cttatgaatc tgcccagatc cactacacct acagcctctg     2880

tccttcccac tcagactcag agttcgtctc ctgctgggtg gaattctccc acgaacggct     2940

ggaggagtac aagtggaatt acttagatca gtatatctgt tctgccggct ctgaagactt     3000

cagcttaatt gagtccctga agttctggag gacccgcttc ctgctgctgc cagcctgtgt     3060

caccgccacc aagcgcatca cggaggggga ggcccactgc gacatctatg gggacaggcc     3120

ccgtgcagac gaggacgagt ggcaactcct ggatggtttt gtccgctttg tggagggctt     3180

gaatcgcatt cgcaggcggc atcgctcgga tcgcatgatg cggaaaggga ccgccatgaa     3240

aggcttgcag atgactgggc ccatttccac gcattctctg gagtcaactg cacccccagt     3300

ggggaagaag ggaacctcag ctctctctgc cctgttggag atggaggcca gtcagaagtg     3360

cctgggagaa cagcaggcag ctgtgcatgg tgggaagagc tccgcccagt cagccgagag     3420

cagcagcgtt gccatgactc ccacctacat ggacagccca cgaaaggacg gggccttctt     3480

tatggagttt gtccgcagcc cacgcacagc atcgtccgcc ttctaccctc aggtatctgt     3540

ggaccaaaca gccactccta tgttggacgg caccagtttg ggcatatgca caggccaatc     3600

catggacaga ggcaacagcc agacctttgg gaactcccag aacataggag aacagggcta     3660

ctcctccaca aactccagtg acagcagctc tcagcagctg gtggcaagct ccttgacctc     3720

atcctctacc ctgacagaga tcctggaagc catgaagcac ccctcgacag gagtccagct     3780

gctctctgaa cagaagggcc tctcaccgta ctgcttcatc agcgcggagg tggtacactg     3840

gttggtgaac cacgtggagg ggatccagac acaggcgatg gccattgaca tcatgcagaa     3900

aatgctggaa gagcagctca tcacacatgc atctggcgaa gcctggcgga ccttcatcta     3960

cggcttctat ttctacaaga tagtaacgga caaagagccc gaccgagtgg ccatgcagca     4020

gcccgccacc acctggcaca cagcaggagt ggacgacttc gccagcttcc agcgcaagtg     4080

gtttgaggtg gcctttgtgg cagaagagct cgtgcactct gagattcctg cctttctcct     4140

gccctggctg cctagccggc cagcctccta tgcaagtagg cacagctcct ttagccgaag     4200

ttttggagga cggagccagg cggcagcact tttagctgcc actgtcccag agcagaggac     4260

tgtgaccctg gatgttgacg tgaacaaccg cacagaccgg ctggagtggt gcagctgtta     4320

ttaccatggc aacttttctc tgaatgcagc ctttgagatc aagctgcact ggatggcggt     4380

gaccgcagca gtactcttcg agatggtcca aggttggcat cggaaagcca cctcctgtgg     4440

cttcttgtta gtcccagttt tggaggggcc ttttgcactg cccagttacc tgtatggcga     4500

cccccttcgt gcccagctct tcatcccact caacatcagc tgcttgctca aggagggcag     4560

cgagcacctg tttgatagct ttgaacccga aacgtactgg gatcgaatgc acctcttcca     4620

ggaagccatt gcacacaggt ttgggtttgt acaagataaa tattctgcct ctgcttttaa     4680

cttccctgct gagaacaagc ctcagtatat ccacgttaca ggaacagtgt ttctgcagct     4740

gccctactcc aagcgcaagt tctcagggca gcagcggcgg cggcggaact ccaccagctc     4800

caccaaccag aacatgttct gcgaggagcg ggtcggctac aactgggcct acaacaccat     4860

gctcaccaaa acatggcgct ccagcgccac aggggatgaa aagtttgctg atcggctgct     4920

gaaggacttc acggacttct gcatcaaccg tgacaaccgg ctggtcacgt tctggacaag     4980

ttgcctggag aagatgcatg ccagtgcccc gtgaggccag gctgcacctg tgctggggga     5040

aggtgggtga gccactgccc tcaaacccgg ggcggaggat tccaggcagg ctctaggagt     5100

caggtgtccg tttgctgcta tcagtgagtg ggggccattg ttttttgttt gtttgtttgt     5160

ttgtttgttt gtttttggcc cccacgacaa gtcttctact ctagaagaaa gactttggaa     5220

gcagctgctg ctgctgccac cactcctgtc agcaagtgct cagagcaggt gggaggcaca     5280

gattgtccgt gggagggctc cagtgtctgg gaagagggca ggcggccccc atgaatgtcc     5340

tcggaagggg gtggctcctg gtagcatcct tttccttcac catctatggg atattagggg     5400

cagaatctgc cacttcttgc ccaggagtgt gcacagatgt aagataattt tgtgaaataa     5460

tgtaccatag actctcacca actgtatata cctgtacata tcagaagcaa ataaagagct     5520

ccacgtgcat catttctttc cccacccagt t                                    5551


<210>  24
<211>  1603
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Arg Thr Thr Lys Val Tyr Lys Leu Val Ile His Lys Lys Gly Phe 
1               5                   10                  15      


Gly Gly Ser Asp Asp Glu Leu Val Val Asn Pro Lys Val Phe Pro His 
            20                  25                  30          


Ile Lys Leu Gly Asp Ile Val Glu Ile Ala His Pro Asn Asp Glu Tyr 
        35                  40                  45              


Ser Pro Leu Leu Leu Gln Val Lys Ser Leu Lys Glu Asp Leu Gln Lys 
    50                  55                  60                  


Glu Thr Ile Ser Val Asp Gln Thr Val Thr Gln Val Phe Arg Leu Arg 
65                  70                  75                  80  


Pro Tyr Gln Asp Val Tyr Val Asn Val Val Asp Pro Lys Asp Val Thr 
                85                  90                  95      


Leu Asp Leu Val Glu Leu Thr Phe Lys Asp Gln Tyr Ile Gly Arg Gly 
            100                 105                 110         


Asp Met Trp Arg Leu Lys Lys Ser Leu Val Ser Thr Cys Ala Tyr Ile 
        115                 120                 125             


Thr Gln Lys Val Glu Phe Ala Gly Ile Arg Ala Gln Ala Gly Glu Leu 
    130                 135                 140                 


Trp Val Lys Asn Glu Lys Val Met Cys Gly Tyr Ile Ser Glu Asp Thr 
145                 150                 155                 160 


Arg Val Val Phe Arg Ser Thr Ser Ala Met Val Tyr Ile Phe Ile Gln 
                165                 170                 175     


Met Ser Cys Glu Met Trp Asp Phe Asp Ile Tyr Gly Asp Leu Tyr Phe 
            180                 185                 190         


Glu Lys Ala Val Asn Gly Phe Leu Ala Asp Leu Phe Thr Lys Trp Lys 
        195                 200                 205             


Glu Lys Asn Cys Ser His Glu Val Thr Val Val Leu Phe Ser Arg Thr 
    210                 215                 220                 


Phe Tyr Asp Ala Lys Ser Val Asp Glu Phe Pro Glu Ile Asn Arg Ala 
225                 230                 235                 240 


Ser Ile Arg Gln Asp His Lys Gly Arg Phe Tyr Glu Asp Phe Tyr Lys 
                245                 250                 255     


Val Val Val Gln Asn Glu Arg Arg Glu Glu Trp Thr Ser Leu Leu Val 
            260                 265                 270         


Thr Ile Lys Lys Leu Phe Ile Gln Tyr Pro Val Leu Val Arg Leu Glu 
        275                 280                 285             


Gln Ala Glu Gly Phe Pro Gln Gly Asp Asn Ser Thr Ser Ala Gln Gly 
    290                 295                 300                 


Asn Tyr Leu Glu Ala Ile Asn Leu Ser Phe Asn Val Phe Asp Lys His 
305                 310                 315                 320 


Tyr Ile Asn Arg Asn Phe Asp Arg Thr Gly Gln Met Ser Val Val Ile 
                325                 330                 335     


Thr Pro Gly Val Gly Val Phe Glu Val Asp Arg Leu Leu Met Ile Leu 
            340                 345                 350         


Thr Lys Gln Arg Met Ile Asp Asn Gly Ile Gly Val Asp Leu Val Cys 
        355                 360                 365             


Met Gly Glu Gln Pro Leu His Ala Val Pro Leu Phe Lys Leu His Asn 
    370                 375                 380                 


Arg Ser Ala Pro Arg Asp Ser Arg Leu Gly Asp Asp Tyr Asn Ile Pro 
385                 390                 395                 400 


His Trp Ile Asn His Ser Phe Tyr Thr Ser Lys Ser Gln Leu Phe Cys 
                405                 410                 415     


Asn Ser Phe Thr Pro Arg Ile Lys Leu Ala Gly Lys Lys Pro Ala Ser 
            420                 425                 430         


Glu Lys Ala Lys Asn Gly Arg Asp Thr Ser Leu Gly Ser Pro Lys Glu 
        435                 440                 445             


Ser Glu Asn Val Leu Pro Ile Gln Val Asp Tyr Asp Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Val Phe Arg Leu Pro Gly Pro Ser Arg Ala Gln Cys Leu Thr Thr 
465                 470                 475                 480 


Cys Arg Ser Val Arg Glu Arg Glu Ser His Ser Arg Lys Ser Ala Ser 
                485                 490                 495     


Ser Cys Asp Val Ser Ser Ser Pro Ser Leu Pro Ser Arg Thr Leu Pro 
            500                 505                 510         


Thr Glu Glu Val Arg Ser Gln Ala Ser Asp Asp Ser Ser Leu Gly Lys 
        515                 520                 525             


Ser Ala Asn Ile Leu Met Ile Pro His Pro His Leu His Gln Tyr Glu 
    530                 535                 540                 


Val Ser Ser Ser Leu Gly Tyr Thr Ser Thr Arg Asp Val Leu Glu Asn 
545                 550                 555                 560 


Met Met Glu Pro Pro Gln Arg Asp Ser Ser Ala Pro Gly Arg Phe His 
                565                 570                 575     


Val Gly Ser Ala Glu Ser Met Leu His Val Arg Pro Gly Gly Tyr Thr 
            580                 585                 590         


Pro Gln Arg Ala Leu Ile Asn Pro Phe Ala Pro Ser Arg Met Pro Met 
        595                 600                 605             


Lys Leu Thr Ser Asn Arg Arg Arg Trp Met His Thr Phe Pro Val Gly 
    610                 615                 620                 


Pro Ser Gly Glu Ala Ile Gln Ile His His Gln Thr Arg Gln Asn Met 
625                 630                 635                 640 


Ala Glu Leu Gln Gly Ser Gly Gln Arg Asp Pro Thr His Ser Ser Ala 
                645                 650                 655     


Glu Leu Leu Glu Leu Ala Tyr His Glu Ala Ala Gly Arg His Ser Asn 
            660                 665                 670         


Ser Arg Gln Pro Gly Asp Gly Met Ser Phe Leu Asn Phe Ser Gly Thr 
        675                 680                 685             


Glu Glu Leu Ser Val Gly Leu Leu Ser Asn Ser Gly Ala Gly Met Asn 
    690                 695                 700                 


Pro Arg Thr Gln Asn Lys Asp Ser Leu Glu Asp Ser Val Ser Thr Ser 
705                 710                 715                 720 


Pro Asp Pro Ile Leu Thr Leu Ser Ala Pro Pro Val Val Pro Gly Phe 
                725                 730                 735     


Cys Cys Thr Val Gly Val Asp Trp Lys Ser Leu Thr Thr Pro Ala Cys 
            740                 745                 750         


Leu Pro Leu Thr Thr Asp Tyr Phe Pro Asp Arg Gln Gly Leu Gln Asn 
        755                 760                 765             


Asp Tyr Thr Glu Gly Cys Tyr Asp Leu Leu Pro Glu Ala Asp Ile Asp 
    770                 775                 780                 


Arg Arg Asp Glu Asp Gly Val Gln Met Thr Ala Gln Gln Val Phe Glu 
785                 790                 795                 800 


Glu Phe Ile Cys Gln Arg Leu Met Gln Gly Tyr Gln Ile Ile Val Gln 
                805                 810                 815     


Pro Lys Thr Gln Lys Pro Asn Pro Ala Val Pro Pro Pro Leu Ser Ser 
            820                 825                 830         


Ser Pro Leu Tyr Ser Arg Gly Leu Val Ser Arg Asn Arg Pro Glu Glu 
        835                 840                 845             


Glu Asp Gln Tyr Trp Leu Ser Met Gly Arg Thr Phe His Lys Val Thr 
    850                 855                 860                 


Leu Lys Asp Lys Met Ile Thr Val Thr Arg Tyr Leu Pro Lys Tyr Pro 
865                 870                 875                 880 


Tyr Glu Ser Ala Gln Ile His Tyr Thr Tyr Ser Leu Cys Pro Ser His 
                885                 890                 895     


Ser Asp Ser Glu Phe Val Ser Cys Trp Val Glu Phe Ser His Glu Arg 
            900                 905                 910         


Leu Glu Glu Tyr Lys Trp Asn Tyr Leu Asp Gln Tyr Ile Cys Ser Ala 
        915                 920                 925             


Gly Ser Glu Asp Phe Ser Leu Ile Glu Ser Leu Lys Phe Trp Arg Thr 
    930                 935                 940                 


Arg Phe Leu Leu Leu Pro Ala Cys Val Thr Ala Thr Lys Arg Ile Thr 
945                 950                 955                 960 


Glu Gly Glu Ala His Cys Asp Ile Tyr Gly Asp Arg Pro Arg Ala Asp 
                965                 970                 975     


Glu Asp Glu Trp Gln Leu Leu Asp Gly Phe Val Arg Phe Val Glu Gly 
            980                 985                 990         


Leu Asn Arg Ile Arg Arg Arg His  Arg Ser Asp Arg Met  Met Arg Lys 
        995                 1000                 1005             


Gly Thr  Ala Met Lys Gly Leu  Gln Met Thr Gly Pro  Ile Ser Thr 
    1010                 1015                 1020             


His Ser  Leu Glu Ser Thr Ala  Pro Pro Val Gly Lys  Lys Gly Thr 
    1025                 1030                 1035             


Ser Ala  Leu Ser Ala Leu Leu  Glu Met Glu Ala Ser  Gln Lys Cys 
    1040                 1045                 1050             


Leu Gly  Glu Gln Gln Ala Ala  Val His Gly Gly Lys  Ser Ser Ala 
    1055                 1060                 1065             


Gln Ser  Ala Glu Ser Ser Ser  Val Ala Met Thr Pro  Thr Tyr Met 
    1070                 1075                 1080             


Asp Ser  Pro Arg Lys Asp Gly  Ala Phe Phe Met Glu  Phe Val Arg 
    1085                 1090                 1095             


Ser Pro  Arg Thr Ala Ser Ser  Ala Phe Tyr Pro Gln  Val Ser Val 
    1100                 1105                 1110             


Asp Gln  Thr Ala Thr Pro Met  Leu Asp Gly Thr Ser  Leu Gly Ile 
    1115                 1120                 1125             


Cys Thr  Gly Gln Ser Met Asp  Arg Gly Asn Ser Gln  Thr Phe Gly 
    1130                 1135                 1140             


Asn Ser  Gln Asn Ile Gly Glu  Gln Gly Tyr Ser Ser  Thr Asn Ser 
    1145                 1150                 1155             


Ser Asp  Ser Ser Ser Gln Gln  Leu Val Ala Ser Ser  Leu Thr Ser 
    1160                 1165                 1170             


Ser Ser  Thr Leu Thr Glu Ile  Leu Glu Ala Met Lys  His Pro Ser 
    1175                 1180                 1185             


Thr Gly  Val Gln Leu Leu Ser  Glu Gln Lys Gly Leu  Ser Pro Tyr 
    1190                 1195                 1200             


Cys Phe  Ile Ser Ala Glu Val  Val His Trp Leu Val  Asn His Val 
    1205                 1210                 1215             


Glu Gly  Ile Gln Thr Gln Ala  Met Ala Ile Asp Ile  Met Gln Lys 
    1220                 1225                 1230             


Met Leu  Glu Glu Gln Leu Ile  Thr His Ala Ser Gly  Glu Ala Trp 
    1235                 1240                 1245             


Arg Thr  Phe Ile Tyr Gly Phe  Tyr Phe Tyr Lys Ile  Val Thr Asp 
    1250                 1255                 1260             


Lys Glu  Pro Asp Arg Val Ala  Met Gln Gln Pro Ala  Thr Thr Trp 
    1265                 1270                 1275             


His Thr  Ala Gly Val Asp Asp  Phe Ala Ser Phe Gln  Arg Lys Trp 
    1280                 1285                 1290             


Phe Glu  Val Ala Phe Val Ala  Glu Glu Leu Val His  Ser Glu Ile 
    1295                 1300                 1305             


Pro Ala  Phe Leu Leu Pro Trp  Leu Pro Ser Arg Pro  Ala Ser Tyr 
    1310                 1315                 1320             


Ala Ser  Arg His Ser Ser Phe  Ser Arg Ser Phe Gly  Gly Arg Ser 
    1325                 1330                 1335             


Gln Ala  Ala Ala Leu Leu Ala  Ala Thr Val Pro Glu  Gln Arg Thr 
    1340                 1345                 1350             


Val Thr  Leu Asp Val Asp Val  Asn Asn Arg Thr Asp  Arg Leu Glu 
    1355                 1360                 1365             


Trp Cys  Ser Cys Tyr Tyr His  Gly Asn Phe Ser Leu  Asn Ala Ala 
    1370                 1375                 1380             


Phe Glu  Ile Lys Leu His Trp  Met Ala Val Thr Ala  Ala Val Leu 
    1385                 1390                 1395             


Phe Glu  Met Val Gln Gly Trp  His Arg Lys Ala Thr  Ser Cys Gly 
    1400                 1405                 1410             


Phe Leu  Leu Val Pro Val Leu  Glu Gly Pro Phe Ala  Leu Pro Ser 
    1415                 1420                 1425             


Tyr Leu  Tyr Gly Asp Pro Leu  Arg Ala Gln Leu Phe  Ile Pro Leu 
    1430                 1435                 1440             


Asn Ile  Ser Cys Leu Leu Lys  Glu Gly Ser Glu His  Leu Phe Asp 
    1445                 1450                 1455             


Ser Phe  Glu Pro Glu Thr Tyr  Trp Asp Arg Met His  Leu Phe Gln 
    1460                 1465                 1470             


Glu Ala  Ile Ala His Arg Phe  Gly Phe Val Gln Asp  Lys Tyr Ser 
    1475                 1480                 1485             


Ala Ser  Ala Phe Asn Phe Pro  Ala Glu Asn Lys Pro  Gln Tyr Ile 
    1490                 1495                 1500             


His Val  Thr Gly Thr Val Phe  Leu Gln Leu Pro Tyr  Ser Lys Arg 
    1505                 1510                 1515             


Lys Phe  Ser Gly Gln Gln Arg  Arg Arg Arg Asn Ser  Thr Ser Ser 
    1520                 1525                 1530             


Thr Asn  Gln Asn Met Phe Cys  Glu Glu Arg Val Gly  Tyr Asn Trp 
    1535                 1540                 1545             


Ala Tyr  Asn Thr Met Leu Thr  Lys Thr Trp Arg Ser  Ser Ala Thr 
    1550                 1555                 1560             


Gly Asp  Glu Lys Phe Ala Asp  Arg Leu Leu Lys Asp  Phe Thr Asp 
    1565                 1570                 1575             


Phe Cys  Ile Asn Arg Asp Asn  Arg Leu Val Thr Phe  Trp Thr Ser 
    1580                 1585                 1590             


Cys Leu  Glu Lys Met His Ala  Ser Ala Pro 
    1595                 1600             


<210>  25
<211>  4404
<212>  DNA
<213>  Homo sapiens


<220>
<221>  exon
<222>  (1)..(46)

<220>
<221>  Intron
<222>  (47)..(4318)

<220>
<221>  exon
<222>  (4319)..(4404)

<400>  25
cct ctg ctt ttg cag gtc aag tct ctt aag gaa gat tta cag aag g           46
Pro Leu Leu Leu Gln Val Lys Ser Leu Lys Glu Asp Leu Gln Lys               
1               5                   10                  15                

ataagaatta tatcactctt cttagaattt tttatttact gcctcagaaa ctgtaagaaa      106

tctctcttca taatttcaag ggatgagggc aagtaattct cttctttttt aaacaaattt      166

taatttaact ttcaattcag gcagtacatg ggaatgtttg ttacatgggt atattgtgta      226

ctggtgggga ttgggcttct attgtatcca ttacacagtg aaccttgtat ctgacagaac      286

agatacagat aaagaatgtt gtatctgtgt cttaacattg tttttttttt tttttctgag      346

acagtgtctt gttctgtcac ccaggttgga gtgcagtggc gcgatctcgg ctcactgcaa      406

gctccgcctc ctgggttcac accattctcc tccctcagcc tcccaagtag ctgggactac      466

aggcacctgc caccacgcct ggctaatttt ttgtattttt agtagacacg aggtttcacc      526

gtgttagcca ggatggtctc aatctcctga cttcatgatc ctcctgcctt ggccccccaa      586

agtgctggga ttacaggcgt gagccaccac acccagcctg aacattgtat ttttcaacct      646

tcattctctt ccctgtcctt gtttttggag tcccaagtgt ctattatttc catcccactt      706

ataggtaaga acatgcagta tttggttttc tgtttgtgag ttagttcact taggataatg      766

gtggcctcca actccatcca tgttgctgca gtggacatga ttccattttt ttatgactgt      826

agttctcttc ttatcaaact atgttgccac taaaaaaaaa attgtaaagt gacgcttata      886

gtcctagcta ctctggaggc tgaggtggaa ggatcattgg gtcccaagag tttgaggttt      946

caatgagcta taacggtgcc accgcagtct agcctggtca acagagcaag accctatctc     1006

aaaaaaaaaa aaaaaaaaaa ataggccagg cacggtggct tatgcctgta atcctgggag     1066

tttgggcggc tgaggcaggc ggattgcctg agctcaggag tttgcgacca gcctgggcaa     1126

aacggtgaaa ccctgtctct actaaaatac aaaatattag ccgggtgtgg tggcatgcac     1186

ctataatcct agctaccctg gaggccgagg taggagaatt acttgaaccc gggaggcgga     1246

ggttgcagtg agccgaggtc acgccactgc actccagcct gggcgacaga gcgagactcc     1306

ggctcaaaaa aaaaaaaaaa aaaaaaatac acaacctgcc tgttgcccag gttggtcttg     1366

aactcctggc ctcaagtgga gttcctgaca ccttgacctc ccaaagtgct aagattgcag     1426

gtgtgatcca ccacatctgt cccatttttt cacaaactat ttgttaaatg cctactctgg     1486

gtgagtaggg attggggagg aagaaatata tattgatgat cgcccaccac attgtgcaag     1546

gtactatcct gggagctttg tgtaatctag cattatcttc ccaacaactc ttgagtgagt     1606

gaggaagttt attatctgcc ggactataca gtctaggcgt agccagaagc agtgattcct     1666

gcttacttat tctggattca aatcctttct ttttccctct aatggctatg ccatgctgtt     1726

caaggaacca aaatgttaat tgaaagtaaa taagatactc ttttaaatag ttcttaagag     1786

aaaaaaacaa aattctgggt tgctctaaag ggctttgatg gctgggtgca gtggctgacg     1846

cctgtaatcc caacactttg ggaggctgaa gtaggtggat cacctgaggt caggagtttg     1906

agaccagcct gaccaacatg gtaaaacccc gtctctacta aaaatataaa attagccagg     1966

cattgtggcg catgcctgta atctcagcta ctcgggaagc tgaggcagga gaattgcttg     2026

aatctgggag gcagaagttg tggtgagctg agatcacgcc attgcactcc agcctgggca     2086

acaagaacaa aactctgtct ctaaataaat aaataaataa aataaagggc tttgatgtca     2146

cccactcttt cttttttttt aaagagatgg cgtctcactc tgttgcccag gctggagtct     2206

ggagtgcagt ctcacaatct tggctgactg caacctgcgc ctcctgggtt caagtgattc     2266

tcctgcctca gcctcccagg tagttaggac tacaggcgtg caccaccatg cctggctaat     2326

ttttatattt atatttttat ttttttgaga tggagtctca ctctgtcacc caggctggaa     2386

cgcaatgaca tggtctcagc tcactgcaac ctccgcctcc tggattcaag ggattctcct     2446

gcctcagcct cctcagtagc tgggattaca ggtgcacgcc accacacccg gctaattttt     2506

gtatttttag tggagacagg gtttcactat gttgtccagg ctagtctcga actgctgacc     2566

tcgtgatccg ccctcctcgg cctcccaaag tgctgggatt acagacatga gccaccatgc     2626

ccggcctaat ttttatatat ttagtagaga tggggtttca ccatgttggc caggctggtc     2686

tcaaattcct caccccaggt gatctgcctg cctcaacctc ccaaagtcct gggattacag     2746

gcgtgagcca ctgcaccatt gcccctgcct tttttttttt tctttttccc tttcagacag     2806

ggcctctctc tgttgtccag actggagtgc agtggtgcag tcacggctca ctgcagcctc     2866

aacctccctg ggtgcaaatg attctccatc tcccacctcc gcctcccgag tagctaagac     2926

cccagacgcc cagcccacag gatcatgcct ggctaatttt ttttttttta atttttgctc     2986

aggctggtct tgaactcctg ggcccaagca gtcctcatgc cttggcctcc taaagtgcta     3046

ggattacagg catgagtcac catgcctggc tatccactca tatttaacaa ttcaatattt     3106

caatttgagg agaaaacatt ctataaaacc tggctactct ggttacgctg cctatgggtt     3166

atccctgctc tgcaaggagc agtaaaaaaa aaatttaaag ttttcatttt tattgttatg     3226

ttgtgtggtg ttatgttttt tatgttatgt tatgttatgt ttgttatgtt atgttatgtt     3286

attttgagat ggagtatccc tctgtcgccc aggctggagt gcagtggtgt gattttggct     3346

cactgcaact tccacctcct aggttcaagc aattctcctg cctctgcctc ctgagtagct     3406

gggactacag gtgcgcacca cgacacctgg ctaaattttt tttgtatttt tagtagaggc     3466

ggggtttcac catgttggtc aggctggtct tgaactcctg acctcatgat ctgctgagcc     3526

accacatgca gccaatttaa agattttaaa agaattctat aaaaccttaa tcctaagaat     3586

ggccttcata ccttcccctt atctcctgcc ccatgttacg tttcttacca gacttaaggg     3646

ctcattgaaa aatttgtttc ttctttacca ctgataactt cattccaaag agaagatctc     3706

ctttctcttc tggagtttta caggtctttg aactttctta tcttccttct tatttaattt     3766

atttatttat tgagacagag tctcattctg tcacccaggt tggagtgcag tggtacgatc     3826

tcagctcgct acaacctctg tctctggggt tcaagcgatt tgtatgcctc agcctcccaa     3886

gtagcttgga ttacaggcgc ccaccatcat gcctggctaa tttttgtgtt tttagtagag     3946

acagggtttc accatgttgg ccaggctggt ctcgaactgc tgacctcagg tgatcttcct     4006

gcctagacct cccaaagtgc tgagattaca ggtgttagcc accataccca gcctcttcct     4066

tcttaaattc tttattttcc ctcccttctc cctttttctc tccatttttg ttgattgctt     4126

aggctctggt cttatttcac ctaaaaagca gagaattgtt taaattctaa gctcctgaaa     4186

ggaagagact gtgtgttgcc cgtgtcagat gatcaattgt gttgcttact gagttgagtg     4246

tttatagatt agaatatatg gatctgcttt ttcaaaatat gttatctgag ccagatattg     4306

tttctgtttt ag aa  act atc agt gtg gac cag act gtg act caa gtg ttc     4356
              Glu Thr Ile Ser Val Asp Gln Thr Val Thr Gln Val Phe         
                              20                  25                      

cgg ctg aga cct tat cag gat gtc tat gtt aat gtc gta gac cct aag       4404
Arg Leu Arg Pro Tyr Gln Asp Val Tyr Val Asn Val Val Asp Pro Lys           
    30                  35                  40                            


<210>  26
<211>  1692
<212>  DNA
<213>  Homo sapiens


<220>
<221>  exon
<222>  (1)..(84)

<220>
<221>  Intron
<222>  (85)..(1608)

<220>
<221>  exon
<222>  (1609)..(1692)

<400>  26
act atc agt gtg gac cag act gtg act caa gtg ttc cgg ctg aga cct         48
Thr Ile Ser Val Asp Gln Thr Val Thr Gln Val Phe Arg Leu Arg Pro           
1               5                   10                  15                

tat cag gat gtc tat gtt aat gtc gta gac cct aag atatgtcttt              94
Tyr Gln Asp Val Tyr Val Asn Val Val Asp Pro Lys                           
            20                  25                                        

gttttgtact tgaatatctt tttggaataa gcacccttcc tcaaggttag attactaagg      154

aaacaatggg ttacttaagt gtagtgttag cctattaaat gtgtggcctg ctaggtgtgg      214

taatttcagt acatcaggag gctgagacag gaggatcact tgaggccagg agttcaagac      274

cagcctgagc agcatagtta gaccttgtct ttattaaaac tttccttttt cttttttttg      334

aaatggagta tcactgttgc ccaggctgga gtgcagtggc gtgatctcgg ctcactgcaa      394

ctggtgcctc ccaggttcaa gccattctcc tgcctcagcc tcctgagtag ctaggattac      454

aggcctgcac caccgcaccc agctaatttt tgtatttttg tagagacagg gtttcaccat      514

attggccagg ctgttcttga actcctgacc tcaggtgatc cacctgcctt ggcctcccag      574

agtgctggga ttccaggtag gagctaccgc gtcctgccta ctaaaacttt tctaaaagat      634

tagctgggtg tgttgtatat gcctgtagtt ccaactacgt gaaaggctgc aacaggagga      694

ttgcttgtgc gctattgcac ttcagcctgg gcaacagaac aagaccttgt cttgtaaaac      754

taaacatgta gaccatgggt ggtggcccat gcctgtaatc ccagcacttt gggaggccaa      814

ggcaggcgga tgacttgagg tcaggagttt gagaccagcc tgggaaacat ggtgaaaccc      874

tgtctctact aaaaatacag aacttagctg ggtgtggtgg cgcacccctg aagtcccatc      934

tactcgggag gctgaggcat gagagtcact tgagcccagg aggcggaggc tgcagtgagt      994

gagctgagat cgtgccactg cactccaacc tgggcaacag caatatcctg tctcaaaaaa     1054

taataataac taaataaata tgtagcctac atgtcattta gaatgtaggc agtatgtagg     1114

ttgcatttaa aacccaccac cacttttctt gaagcttgtc ctaaccattt tctgtatgtg     1174

aaactatatg taaaactttc tattaaaata ctaacatttt aaaatgtatt ctcatttttc     1234

ttcaagaagt gatgttataa tagataaaaa ttattgtcca gaaagtacta ttgacattaa     1294

tagggaaata aagtacatag gtaagtgtca tgtttgtgtg ccagaatcca gactaaaata     1354

cagaatgagt cccccactac ccatcacact caatgtgcta cagcagctat aggatcagtt     1414

gtagatttac caactatact gaaaagtgtg cttttgcagg atataattct gttcatcaga     1474

gttctgctac tgaatggtct tccagtagtt ttcttttttg caataagttt ttttccatgg     1534

taagtgggca ttaccttctg actataaagt gtggcaaagt aatgtcagag atatcatttg     1594

attattcctt ttag gat gtg acc ctt gac cta gtg gaa tta act ttt aag       1644
                Asp Val Thr Leu Asp Leu Val Glu Leu Thr Phe Lys           
                    30                  35                  40            

gat cag tat att ggc cgt ggg gat atg tgg cga cta aag aaa agt ttg       1692
Asp Gln Tyr Ile Gly Arg Gly Asp Met Trp Arg Leu Lys Lys Ser Leu           
                45                  50                  55                


<210>  27
<211>  5551
<212>  DNA
<213>  Homo sapiens

<400>  27
ctagtaggcg cttcaggctt aggggcggaa cagcgcgggc cgcgcgggcg taggcggggt       60

atctggagga ggcgcaggga acctggagag ggtccagccc tcagtgcccc ggccagaggc      120

gggaaggggc tctagagctt cgggaggcaa gatgacttct ctgccccaag cttggaacag      180

ctaaagggaa aaacagtgca agatgagaac aacaaaggtc tacaaactcg tcatccacaa      240

gaagggcttt gggggcagtg atgatgagct agttgtgaac cccaaagtgt tccctcacat      300

caagcttgga gacattgtag agattgcaca ccccaacgat gaatacagcc ctctgctttt      360

gcaggtcaag tctcttaagg aagatttaca gaaggaaact atcagtgtgg accagactgt      420

gactcaagtg ttccggctga gaccttatca ggatgtctat gttaatgtcg tagaccctaa      480

ggatgtgacc cttgacctag tggaattaac ttttaaggat cagtatattg gccgtgggga      540

tatgtggcga ctaaagaaaa gtttggtcag cacatgtgcc tatatcaccc agaaggtgga      600

gtttgctggc atcagagcac aggctggtga actgtgggtt aagaatgaga aggtcatgtg      660

tggctacatc agtgaagata ccagggtggt gtttcgttct acgtcggcta tggtttacat      720

atttattcag atgagctgtg aaatgtggga ttttgatatt tatggggatt tgtattttga      780

gaaagctgtg aatggtttcc ttgctgatct atttaccaag tggaaggaga agaactgtag      840

tcatgaagtg acagtggtcc tgttttctag aactttctat gatgcaaaat ctgttgatga      900

atttcctgaa ataaaccgag cctcaattcg acaggatcac aaggggagat tctatgaaga      960

cttttacaaa gtggtggtgc agaatgagag aagagaagaa tggacttcac ttctcgtaac     1020

cattaaaaaa ctcttcatcc agtatccagt gttggtgcga ctggaacagg cagagggctt     1080

tcctcaagga gataattcta cctcagcaca aggaaactac ctggaggcca tcaatctgtc     1140

attcaatgtg tttgataagc actacatcaa ccgcaacttt gaccgaactg ggcagatgtc     1200

agtggtgatc acgcccgggg tgggtgtctt tgaagtggac cgcctactca tgatcctgac     1260

caagcagcgg atgatagata atggaattgg tgtggatttg gtgtgcatgg gagagcaacc     1320

gttacatgct gtcccattgt tcaagctcca taatcggagt gctccccgtg attctcgtct     1380

gggcgatgac tataatatcc ctcactggat aaaccacagt ttctacacat ccaaaagcca     1440

gctcttttgt aatagtttca ccccacgaat aaaactggca ggaaagaagc ccgcctctga     1500

gaaagcaaaa aatggccgtg atacatctct cgggagtcca aaagaatctg agaacgccct     1560

tcccatccaa gtagattatg acgcctatga cgctcaagtg ttcaggctgc ccggcccatc     1620

ccgggcccag tgcctcacca cctgcagatc tgtgcgagag cgagagagtc acagtcgaaa     1680

gagtgccagc tcctgtgatg tttcatccag cccttcccta ccaagccgca cactgcccac     1740

tgaggaagtg aggagccagg cttctgacga cagctcccta ggcaagagtg ccaacatcct     1800

gatgatccca cacccccacc tgcaccagta tgaagtcagc agctccttgg gatacaccag     1860

cactcgagat gtcctggaga acatgatgga gccaccacag cgagactcca gtgcaccagg     1920

gaggtttcac gttggcagtg cagaatccat gctgcatgtt cgacctggtg gatacacgcc     1980

ccagagagca ctgattaacc ccttcgctcc ctctcggatg cccatgaagc ttacgtccaa     2040

cagaaggcgc tggatgcaca cttttcctgt ggggccatcc ggagaagcca tccagatcca     2100

ccaccagacc cgacagaata tggcggagct acaaggcagc gggcagaggg atccaactca     2160

ctcctctgca gagctgctgg agttagcata tcatgaagct gctggaaggc acagcaattc     2220

ccgccagcct ggtgacggca tgtccttctt gaacttcagt ggaacagagg agctttctgt     2280

cggcctgctt agcaacagtg gtgcaggtat gaatcctagg acccagaata aggattctct     2340

agaggacagt gtttctacct ctccagaccc aattctgaca ctgtctgctc cccctgtagt     2400

gccaggcttc tgttgcacag ttggagtgga ctggaagtct ctcactactc cggcgtgcct     2460

cccccttacc accgactact tccctgaccg ccagggcctg cagaatgact acacagaggg     2520

ctgttatgat ctccttccag aagcagacat cgacaggagg gacgaagatg gtgtgcagat     2580

gacagcccag caggtatttg aagagtttat ttgccaacgt ctcatgcagg gctaccaaat     2640

catagtgcag cccaagacac agaaacccaa tcctgctgtc ccgcccccgc tgagcagtag     2700

cccactctat agccgaggcc ttgtgtcccg aaaccgccct gaggaggagg accagtattg     2760

gctgagtatg ggcagaacgt tccacaaagt gacgctgaag gataagatga tcacagtgac     2820

gcgatacctt cccaagtatc cttatgaatc tgcccagatc cactacacct acagcctctg     2880

tccttcccac tcagactcag agttcgtctc ctgctgggtg gaattctccc acgaacggct     2940

ggaggagtac aagtggaatt acttagatca gtatatctgt tctgccggct ctgaagactt     3000

cagcttaatt gagtccctga agttctggag gacccgcttc ctgctgctgc cagcctgtgt     3060

caccgccacc aagcgcatca cggaggggga ggcccactgc gacatctatg gggacaggcc     3120

ccgtgcagac gaggacgagt ggcaactcct ggatggtttt gtccgctttg tggagggctt     3180

gaatcgcatt cgcaggcggc atcgctcgga tcgcatgatg cggaaaggga ccgccatgaa     3240

aggcttgcag atgactgggc ccatttccac gcattctctg gagtcaactg cacccccagt     3300

ggggaagaag ggaacctcag ctctctctgc cctgttggag atggaggcca gtcagaagtg     3360

cctgggagaa cagcaggcag ctgtgcatgg tgggaagagc tccgcccagt cagccgagag     3420

cagcagcgtt gccatgactc ccacctacat ggacagccca cgaaaggacg gggccttctt     3480

tatggagttt gtccgcagcc cacgcacagc atcgtccgcc ttctaccctc aggtatctgt     3540

ggaccaaaca gccactccta tgttggacgg caccagtttg ggcatatgca caggccaatc     3600

catggacaga ggcaacagcc agacctttgg gaactcccag aacataggag aacagggcta     3660

ctcctccaca aactccagtg acagcagctc tcagcagctg gtggcaagct ccttgacctc     3720

atcctctacc ctgacagaga tcctggaagc catgaagcac ccctcgacag gagtccagct     3780

gctctctgaa cagaagggcc tctcaccgta ctgcttcatc agcgcggagg tggtacactg     3840

gttggtgaac cacgtggagg ggatccagac acaggcgatg gccattgaca tcatgcagaa     3900

aatgctggaa gagcagctca tcacacatgc atctggcgaa gcctggcgga ccttcatcta     3960

cggcttctat ttctacaaga tagtaacgga caaagagccc gaccgagtgg ccatgcagca     4020

gcccgccacc acctggcaca cagcaggagt ggacgacttc gccagcttcc agcgcaagtg     4080

gtttgaggtg gcctttgtgg cagaagagct cgtgcactct gagattcctg cctttctcct     4140

gccctggctg cctagccggc cagcctccta tgcaagtagg cacagctcct ttagccgaag     4200

ttttggagga cggagccagg cggcagcact tttagctgcc actgtcccag agcagaggac     4260

tgtgaccctg gatgttgacg tgaacaaccg cacagaccgg ctggagtggt gcagctgtta     4320

ttaccatggc aacttttctc tgaatgcagc ctttgagatc aagctgcact ggatggcggt     4380

gaccgcagca gtactcttcg agatggtcca aggttggcat cggaaagcca cctcctgtgg     4440

cttcttgtta gtcccagttt tggaggggcc ttttgcactg cccagttacc tgtatggcga     4500

cccccttcgt gcccagctct tcatcccact caacatcagc tgcttgctca aggagggcag     4560

cgagcacctg tttgatagct ttgaacccga aacgtactgg gatcgaatgc acctcttcca     4620

ggaagccatt gcacacaggt ttgggtttgt acaagataaa tattctgcct ctgcttttaa     4680

cttccctgct gagaacaagc ctcagtatat ccatgttaca ggaacagtgt ttctgcagct     4740

gccctactcc aagcgcaagt tctcagggca gcagcggcgg cggcggaact ccaccagctc     4800

caccaaccag aacatgttct gcgaggagcg ggtcggctac aactgggcct acaacaccat     4860

gctcaccaaa acatggcgct ccagcgccac aggggatgaa aagtttgctg atcggctgct     4920

gaaggacttc acggacttct gcatcaaccg tgacaaccgg ctggtcacgt tctggacaag     4980

ttgcctggag aagatgcatg ccagtgcccc gtgaggccag gctgcacctg tgctggggga     5040

aggtgggtga gccactgccc tcaaacccgg ggcggaggat tccaggcagg ctctaggagt     5100

caggtgtccg tttgctgcta tcagtgagtg ggggccattg ttttttgttt gtttgtttgt     5160

ttgtttgttt gtttttggcc cccacgacaa gtcttctact ctagaagaaa gactttggaa     5220

gcagctgctg ctgctgccac cactcctgtc agcaagtgct cagagcaggt gggaggcaca     5280

gattgtccgt gggagggctc cagtgtctgg gaagagggca ggcggccccc atgaatgtcc     5340

tcggaagggg gtggctcctg gtagcatcct tttccttcac catctatggg atattagggg     5400

cagaatctgc cacttcttgc ccaggagtgt gcacagatgt aagataattt tgtgaaataa     5460

tgtaccatag actctcacca actgtatata cctgtacata tcagaagcaa ataaagagct     5520

ccacgtgcat catttctttc cccacccagt t                                    5551


<210>  28
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer - c.488-490delTGT screening

<400>  28
gttttatttc aggtggtt                                                     18


<210>  29
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer - c.488-490delTGT screening

<400>  29
gttttatttc aggtggtg                                                     18


<210>  30
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer - c.488-490delTGT screening

<400>  30
cttagcagtt acaatcagc                                                    19


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 2F

<400>  31
ctgacattcc aaccttttcg                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 2R

<400>  32
cagaacctca gccaacttac                                                   20


<210>  33
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 3F

<400>  33
tacagtgtac ctaatgagtg ttt                                               23


<210>  34
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 3R

<400>  34
aacagtgaat tgcccag                                                      17


<210>  35
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 4F

<400>  35
ggagttactg ttcacggt                                                     18


<210>  36
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 4R

<400>  36
tacagtttct gaggcagtaa ata                                               23


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 5F

<400>  37
caaaatatgt tatctgagcc a                                                 21


<210>  38
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 5R

<400>  38
gaagggtgct tattccaa                                                     18


<210>  39
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 6F

<400>  39
taaagtgtgg caaagtaatg tc                                                22


<210>  40
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 6R

<400>  40
taaacaggga ttattcacat aatgg                                             25


<210>  41
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 7F

<400>  41
tctccctccc tccctctctc ta                                                22


<210>  42
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 7R

<400>  42
agttactgca cagataaggc aag                                               23


<210>  43
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 8F

<400>  43
catgtattgg tttcatgtaa gac                                               23


<210>  44
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 8R

<400>  44
gacttagcca taatagtatg gag                                               23


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 9F

<400>  45
gaactgaaac tgtatatggc                                                   20


<210>  46
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 9R

<400>  46
cttagcagtt acaatcagc                                                    19


<210>  47
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 10F

<400>  47
gattgttctc atgttctcat c                                                 21


<210>  48
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 10R

<400>  48
gtaatgttta cataatgaga cttag                                             25


<210>  49
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 11F

<400>  49
tgaaacaaac ttcaaccct                                                    19


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 11R

<400>  50
gggaagctta acaaaaacat                                                   20


<210>  51
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 12F

<400>  51
cctgaactac atactccg                                                     18


<210>  52
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 12R

<400>  52
tttaagttag gaaagaaaca actaat                                            26


<210>  53
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 13F

<400>  53
agctgctcaa tatccattt                                                    19


<210>  54
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 13R

<400>  54
cctacacttc ctttccc                                                      17


<210>  55
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 14F

<400>  55
agttcatgtt tcatgagatg tt                                                22


<210>  56
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 14R

<400>  56
acatagccat gtggtagg                                                     18


<210>  57
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 15F

<400>  57
gctgtaacat cattattgtg gaa                                               23


<210>  58
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 15R

<400>  58
aacatgtgga gacaggg                                                      17


<210>  59
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 16F

<400>  59
tgtctctgcc attccct                                                      17


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 16R

<400>  60
actccaactg gcctttagta                                                   20


<210>  61
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 17F

<400>  61
tgtagcttat ctgtgctct                                                    19


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 17R

<400>  62
acgcttatca cctactattg                                                   20


<210>  63
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 18F

<400>  63
aaagggaatt tagattaatg actc                                              24


<210>  64
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 18R

<400>  64
agataagact ggaccacata                                                   20


<210>  65
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 19F

<400>  65
tttctagcga aggaaggagt g                                                 21


<210>  66
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 19R

<400>  66
agccagctga ctctcttt                                                     18


<210>  67
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 20F

<400>  67
caggcatgtg tttgaaatgt at                                                22


<210>  68
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 20R

<400>  68
aacttcaggt tttcctacac aat                                               23


<210>  69
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 21F

<400>  69
ctcgcttgat ggtaact                                                      17


<210>  70
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 21R

<400>  70
ccactatatt aagaaagatg tcc                                               23


<210>  71
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 22F

<400>  71
tttcactgtg gttctgtggt tt                                                22


<210>  72
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 22R

<400>  72
agctcctagt ccaaggct                                                     18


<210>  73
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 22aF

<400>  73
caaatcactt tagctgttag c                                                 21


<210>  74
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 22aR

<400>  74
ggatcgattg agtccaggag                                                   20


<210>  75
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 24F

<400>  75
aaagaggtga tgatctacat t                                                 21


<210>  76
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 24R

<400>  76
atctaaacat cccaactcta t                                                 21


<210>  77
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 25F

<400>  77
tttgcagagt gagccttc                                                     18


<210>  78
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 25R

<400>  78
cccacactcc ctgtctac                                                     18


<210>  79
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 26F

<400>  79
ctgttacgtg aggcagttc                                                    19


<210>  80
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 26R

<400>  80
ccaagccaag tgccttt                                                      17


<210>  81
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 26aF

<400>  81
ggtgaccaca tgtaccttt                                                    19


<210>  82
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 26aR

<400>  82
ccaagccaag tgccttt                                                      17


<210>  83
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 27F

<400>  83
aagcatctgt atgagcaat                                                    19


<210>  84
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 27R

<400>  84
cttccacata cacagtagaa g                                                 21


<210>  85
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 28F

<400>  85
ctgttatagg aatgagcttc aa                                                22


<210>  86
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 28R

<400>  86
gccataattc aggacaataa ct                                                22


<210>  87
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 29F

<400>  87
ggcaggaatt tgtctctaac                                                   20


<210>  88
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 29R

<400>  88
ccaaggatgc aaagatgg                                                     18


<210>  89
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 30F

<400>  89
tctcaccacc accctgtgtt                                                   20


<210>  90
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 30R

<400>  90
tctcacacca ggcgcact                                                     18


<210>  91
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 31F

<400>  91
gagcccactt ggctgat                                                      17


<210>  92
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 31R

<400>  92
ctcagggctg tcaaggt                                                      17


<210>  93
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 32F

<400>  93
tgagcaagct gctgtcat                                                     18


<210>  94
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 32R

<400>  94
cacagaacag ctccctgcta                                                   20


<210>  95
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 33F

<400>  95
ctgtgttttc ctgtcagtta tt                                                22


<210>  96
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 33R

<400>  96
ctccccagga acatgag                                                      17


<210>  97
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 33aF

<400>  97
ccactggtac acattccgtt                                                   20


<210>  98
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 33aR

<400>  98
aacagaaggc cagctcat                                                     18


<210>  99
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 34F

<400>  99
actgcatacg tgccatctt                                                    19


<210>  100
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 34R

<400>  100
cttctgggaa ccttccaacc cta                                               23


<210>  101
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 35F

<400>  101
atggggcaca cacatcc                                                      17


<210>  102
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 35R

<400>  102
ggacctaagc aaacagctct at                                                22


<210>  103
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 36F

<400>  103
cctctctgca ggaatttcag agt                                               23


<210>  104
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 36R

<400>  104
ctgtgggcaa ccgcatt                                                      17


<210>  105
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 37F

<400>  105
gttgagtact ccttctctcc c                                                 21


<210>  106
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 37R

<400>  106
acaccctcag accttgt                                                      17


<210>  107
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 38F

<400>  107
tcttcttcat cccactcctt t                                                 21


<210>  108
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 38R

<400>  108
cactgtgagg tgagccaa                                                     18


<210>  109
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 39F

<400>  109
tgtttgaaag aacttggaga t                                                 21


<210>  110
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 39R

<400>  110
ggtcttactg gttgagaca                                                    19


<210>  111
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 40F

<400>  111
tgatcacaac ccaatattta ttc                                               23


<210>  112
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 40R

<400>  112
ctgatttcct tcccactc                                                     18


<210>  113
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 41F

<400>  113
aactaaggag gcgctgatt                                                    19


<210>  114
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 41R

<400>  114
aggaaaggga tgtggacc                                                     18


<210>  115
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 42F

<400>  115
ctggtggctg ccacaca                                                      17


<210>  116
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HRM Analysis Oligonucleotide Primer - DEPDC5 Exon 42R

<400>  116
cagtggctca cccacct                                                      17


<210>  117
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer - mouse Depdc5 quantitative RT-PCR

<400>  117
tggggacaaa ccccgtgcag                                                   20


<210>  118
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer - mouse Depdc5 quantitative RT-PCR

<400>  118
catgcggtct gagcggtggc                                                   20


<210>  119
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer - mouse L38 quantitative RT-PCR

<400>  119
gcgtcgccat gcctcggaaa                                                   20


<210>  120
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Primer - mouse L38 quantitative RT-PCR

<400>  120
cttggcatcc ttccgccggg                                                   20


<210>  121
<211>  5551
<212>  DNA
<213>  Homo sapiens

<400>  121
ctagtaggcg cttcaggctt aggggcggaa cagcgcgggc cgcgcgggcg taggcggggt       60

atctggagga ggcgcaggga acctggagag ggtccagccc tcagtgcccc ggccagaggc      120

gggaaggggc tctagagctt cgggaggcaa gatgacttct ctgccccaag cttggaacag      180

ctaaagggaa aaacagtgca agatgagaac aacaaaggtc tacaaactcg tcatccacaa      240

gaagggcttt gggggcagtg atgatgagct agttgtgaac cccaaagtgt tccctcacat      300

caagcttgga gacattgtag agattgcaca ccccaacgat gaatacagcc ctctgctttt      360

gcaggtcaag tctcttaagg aagatttaca gaaggaaact atcagtgtgg accagactgt      420

gactcaagtg ttccggctga gaccttatca ggatgtctat gttaatgtcg tagaccctaa      480

ggatgtgacc cttgacctag tggaattaac ttttaaggat cagtatattg gccgtgggga      540

tatgtggcga ctaaagaaaa gtttggtcag cacatgtgcc tatatcaccc agaaggtgga      600

gtttgctggc atcagagcac aggctggtga actgtgggtt aagaatgaga aggtcatgtg      660

tggctacatc agtgaagata ccagggtggt gtttcgttct acgtcggcta tggtttacat      720

atttattcag atgagctgtg aaatgtggga ttttgatatt tatggggatt tgtattttga      780

gaaagctgtg aatggtttcc ttgctgatct atttaccaag tggaaggaga agaactgtag      840

tcatgaagtg acagtggtcc tgttttctag aactttctat gatgcaaaat ctgttgatga      900

atttcctgaa ataaaccgag cctcaattcg acaggatcac aaggggagat tctatgaaga      960

cttttacaaa gtggtggtgc agaatgagag aagagaagaa tggacttcac ttctcgtaac     1020

cattaaaaaa ctcttcatcc agtatccagt gttggtgcga ctggaacagg cagagggctt     1080

tcctcaagga gataattcta cctcagcaca aggaaactac ctggaggcca tcaatctgtc     1140

attcaatgtg tttgataagc actacatcaa ccgcaacttt gaccgaactg ggcagatgtc     1200

agtggtgatc acgcccgggg tgggtgtctt tgaagtggac cgcctactca tgatcctgac     1260

caagcagcgg atgatagata atggaattgg tgtggatttg gtgtgcatgg gagagcaacc     1320

gttacatgct gtcccattgt tcaagctcca taatcggagt gctccccgtg attctcgtct     1380

gggcgatgac tataatatcc ctcactggat aaaccacagt ttctacacat ccaaaagcca     1440

gctcttttgt aatagtttca ccccacgaat aaaactggca ggaaagaagc ccgcctctga     1500

gaaagcaaaa aatggccgtg atacatctct cgggagtcca aaagaatctg agaacgccct     1560

tcccatccaa gtagattatg acgcctatga cgctcaagtg ttcaggctgc ccggcccatc     1620

ccgggcccag tgcctcacca cctgcagatc tgtgcgagag cgagagagtc acagtcgaaa     1680

gagtgccagc tcctgtgatg tttcatccag cccttcccta ccaagccgca cactgcccac     1740

tgaggaagtg aggagccagg cttctgacga cagctcccta ggcaagagtg ccaacatcct     1800

gatgatccca cacccccacc tgcaccagta tgaagtcagc agctccttgg gatacaccag     1860

cactcgagat gtcctggaga acatgatgga gccaccacag cgagactcca gtgcaccagg     1920

gaggtttcac gttggcagtg cagaatccat gctgcatgtt cgacctggtg gatacacgcc     1980

ccagagagca ctgattaacc ccttcgctcc ctctcggatg cccatgaagc ttacgtccaa     2040

cagaaggcgc tggatgcaca cttttcctgt ggggccatcc ggagaagcca tccagatcca     2100

ccaccagacc cgacagaata tggcggagct acaaggcagc gggcagaggg atccaactca     2160

ctcctctgca gagctgctgg agttagcata tcatgaagct gctggaaggc acagcaattc     2220

ccgccagcct ggtgacggca tgtccttctt gaacttcagt ggaacagagg agctttctgt     2280

cggcctgctt agcaacagtg gtgcaggtat gaatcctagg acccagaata aggattctct     2340

agaggacagt gtttctacct ctccagaccc aattctgaca ctgtctgctc cccctgtagt     2400

gccaggcttc tgttgcacag ttggagtgga ctggaagtct ctcactactc cggcgtgcct     2460

cccccttacc accgactact tccctgaccg ccagggcctg cagaatgact acacagaggg     2520

ctgttatgat ctccttccag aagcagacat cgacaggagg gacgaagatg gtgtgcagat     2580

gacagcccag caggtatttg aagagtttat ttgccaacgt ctcatgcagg gctaccaaat     2640

catagtgcag cccaagacac agaaacccaa tcctgctgtc ccgcccccgc tgagcagtag     2700

cccactctat agccgaggcc ttgtgtcccg aaaccgccct gaggaggagg accagtattg     2760

gctgagtatg ggcagaacgt tccacaaagt gacgctgaag gataagatga tcacagtgac     2820

gcgatacctt cccaagtatc cttatgaatc tgcccagatc cactacacct acagcctctg     2880

tccttcccac tcagactcag agttcgtctc ctgctgggtg gaattctccc acgaacggct     2940

ggaggagtac aagtggaatt acttagatca gtatatctgt tctgccggct ctgaagactt     3000

cagcttaatt gagtccctga agttctggag gacccgcttc ctgctgctgc cagcctgtgt     3060

caccgccacc aagcgcatca cggaggggga ggcccactgc gacatctatg gggacaggcc     3120

ccgtgcagac gaggacgagt ggcaactcct ggatggtttt gtccgctttg tggagggctt     3180

gaatcgcatt cgcaggcggc atcgctcgga tcgcatgatg cggaaaggga ccgccatgaa     3240

aggcttgcag atgactgggc ccatttccac gcattctctg gagtcaactg cacccccagt     3300

ggggaagaag ggaacctcag ctctctctgc cctgttggag atggaggcca gtcagaagtg     3360

cctgggagaa cagcaggcag ctgtgcatgg tgggaagagc tccgcccagt cagccgagag     3420

cagcagcgtt gccatgactc ccacctacat ggacagccca cgaaaggacg gggccttctt     3480

tatggagttt gtccgcagcc cacgcacagc atcgtccgcc ttctaccctc aggtatctgt     3540

ggaccaaaca gccactccta tgttggacgg caccagtttg ggcatatgca caggccaatc     3600

catggacaga ggcaacagcc agacctttgg gaactcccag aacataggag aacagggcta     3660

ctcctccaca aactccagtg acagcagctc tcagcagctg gtggcaagct ccttgacctc     3720

atcctctacc ctgacagaga tcctggaagc catgaagcac ccctcgacag gagtccagct     3780

gctctctgaa cagaagggcc tctcaccgta ctgcttcatc agcgcggagg tggtacactg     3840

gttggtgaac cacgtggagg ggatccagac acaggcgatg gccattgaca tcatgcagaa     3900

aatgctggaa gagcagctca tcacacatgc atctggcgaa gcctggcgga ccttcatcta     3960

cggcttctat ttctacaaga tagtaacgga caaagagccc gaccgagtgg ccatgcagca     4020

gcccgccacc acctggcaca cagcaggagt ggacgacttc gccagcttcc agcgcaagtg     4080

gtttgaggtg gcctttgtgg cagaagagct cgtgcactct gagattcctg cctttctcct     4140

gccctggctg cctagccggc cagcctccta tgcaagtagg cacagctcct ttagccgaag     4200

ttttggagga cggagccagg cggcagcact tttagctgcc actgtcccag agcagaggac     4260

tgtgaccctg gatgttgacg tgaacaaccg cacagaccgg ctggagtggt gcagctgtta     4320

ttaccatggc aacttttctc tgaatgcagc ctttgagatc aagctgcact ggatggcggt     4380

gaccgcagca gtactcttcg agatggtcca aggttggcat cggaaagcca cctcctgtgg     4440

cttcttgtta gtcccagttt tggaggggcc ttttgcactg cccagttacc tgtatggcga     4500

cccccttcgt gcccagctct tcatcccact caacatcagc tgcttgctca aggagggcag     4560

cgagcacctg tttgatagct ttgaacccga aacgtactgg gatcgaatgc acctcttcca     4620

ggaagccatt gcacacaggt ttgggtttgt acaagataaa tattctgcct ctgcttttaa     4680

cttccctgct gagaacaagc ctcagtatat ccacgttaca ggaacagtgt ttctgcagct     4740

gccctactcc aagcgcaagt tctcagggca gcagcggcgg cggcggaact ccaccagctc     4800

caccaaccag aacatgttct gcgaggagcg ggtcggctac aactgggcct acaacaccat     4860

gctcaccaaa acatggcgct ccagcgccac aggggatgaa aagtttgctg atcggctgct     4920

gaaggacttc acggacttct gcatcaaccg tgacaaccgg ctggtcacgt tctggacaag     4980

ttgcctggag aagatgcatg ccagtgcccc gtgaggccag gctgcacctg tgctggggga     5040

aggtgggtga gccactgccc tcaaacccgg ggcggaggat tccaggcagg ctctaggagt     5100

caggtgtccg tttgctgcta tcagtgagtg ggggccattg ttttttgttt gtttgtttgt     5160

ttgtttgttt gtttttggcc cccacgacaa gtcttctact ctagaagaaa gactttggaa     5220

gcagctgctg ctgctgccac cactcctgtc agcaagtgct cagagcaggt gggaggcaca     5280

gattgtccgt gggagggctc cagtgtctgg gaagagggca ggcggccccc atgaatgtcc     5340

tcggaagggg gtggctcctg gtagcatcct tttccttcac catctatggg atattagggg     5400

cagaatctgc cacttcttgc ccaggagtgt gcacagatgt aagataattt tgtgaaataa     5460

tgtaccatag actctcacca actgtatata cctgtacata tcagaagcaa ataaagagct     5520

ccacgtgcat catttctttc cccacccagt t                                    5551


<210>  122
<211>  1603
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Arg Thr Thr Lys Val Tyr Lys Leu Val Ile His Lys Lys Gly Phe 
1               5                   10                  15      


Gly Gly Ser Asp Asp Glu Leu Val Val Asn Pro Lys Val Phe Pro His 
            20                  25                  30          


Ile Lys Leu Gly Asp Ile Val Glu Ile Ala His Pro Asn Asp Glu Tyr 
        35                  40                  45              


Ser Pro Leu Leu Leu Gln Val Lys Ser Leu Lys Glu Asp Leu Gln Lys 
    50                  55                  60                  


Glu Thr Ile Ser Val Asp Gln Thr Val Thr Gln Val Phe Arg Leu Arg 
65                  70                  75                  80  


Pro Tyr Gln Asp Val Tyr Val Asn Val Val Asp Pro Lys Asp Val Thr 
                85                  90                  95      


Leu Asp Leu Val Glu Leu Thr Phe Lys Asp Gln Tyr Ile Gly Arg Gly 
            100                 105                 110         


Asp Met Trp Arg Leu Lys Lys Ser Leu Val Ser Thr Cys Ala Tyr Ile 
        115                 120                 125             


Thr Gln Lys Val Glu Phe Ala Gly Ile Arg Ala Gln Ala Gly Glu Leu 
    130                 135                 140                 


Trp Val Lys Asn Glu Lys Val Met Cys Gly Tyr Ile Ser Glu Asp Thr 
145                 150                 155                 160 


Arg Val Val Phe Arg Ser Thr Ser Ala Met Val Tyr Ile Phe Ile Gln 
                165                 170                 175     


Met Ser Cys Glu Met Trp Asp Phe Asp Ile Tyr Gly Asp Leu Tyr Phe 
            180                 185                 190         


Glu Lys Ala Val Asn Gly Phe Leu Ala Asp Leu Phe Thr Lys Trp Lys 
        195                 200                 205             


Glu Lys Asn Cys Ser His Glu Val Thr Val Val Leu Phe Ser Arg Thr 
    210                 215                 220                 


Phe Tyr Asp Ala Lys Ser Val Asp Glu Phe Pro Glu Ile Asn Arg Ala 
225                 230                 235                 240 


Ser Ile Arg Gln Asp His Lys Gly Arg Phe Tyr Glu Asp Phe Tyr Lys 
                245                 250                 255     


Val Val Val Gln Asn Glu Arg Arg Glu Glu Trp Thr Ser Leu Leu Val 
            260                 265                 270         


Thr Ile Lys Lys Leu Phe Ile Gln Tyr Pro Val Leu Val Arg Leu Glu 
        275                 280                 285             


Gln Ala Glu Gly Phe Pro Gln Gly Asp Asn Ser Thr Ser Ala Gln Gly 
    290                 295                 300                 


Asn Tyr Leu Glu Ala Ile Asn Leu Ser Phe Asn Val Phe Asp Lys His 
305                 310                 315                 320 


Tyr Ile Asn Arg Asn Phe Asp Arg Thr Gly Gln Met Ser Val Val Ile 
                325                 330                 335     


Thr Pro Gly Val Gly Val Phe Glu Val Asp Arg Leu Leu Met Ile Leu 
            340                 345                 350         


Thr Lys Gln Arg Met Ile Asp Asn Gly Ile Gly Val Asp Leu Val Cys 
        355                 360                 365             


Met Gly Glu Gln Pro Leu His Ala Val Pro Leu Phe Lys Leu His Asn 
    370                 375                 380                 


Arg Ser Ala Pro Arg Asp Ser Arg Leu Gly Asp Asp Tyr Asn Ile Pro 
385                 390                 395                 400 


His Trp Ile Asn His Ser Phe Tyr Thr Ser Lys Ser Gln Leu Phe Cys 
                405                 410                 415     


Asn Ser Phe Thr Pro Arg Ile Lys Leu Ala Gly Lys Lys Pro Ala Ser 
            420                 425                 430         


Glu Lys Ala Lys Asn Gly Arg Asp Thr Ser Leu Gly Ser Pro Lys Glu 
        435                 440                 445             


Ser Glu Asn Ala Leu Pro Ile Gln Val Asp Tyr Asp Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Val Phe Arg Leu Pro Gly Pro Ser Arg Ala Gln Cys Leu Thr Thr 
465                 470                 475                 480 


Cys Arg Ser Val Arg Glu Arg Glu Ser His Ser Arg Lys Ser Ala Ser 
                485                 490                 495     


Ser Cys Asp Val Ser Ser Ser Pro Ser Leu Pro Ser Arg Thr Leu Pro 
            500                 505                 510         


Thr Glu Glu Val Arg Ser Gln Ala Ser Asp Asp Ser Ser Leu Gly Lys 
        515                 520                 525             


Ser Ala Asn Ile Leu Met Ile Pro His Pro His Leu His Gln Tyr Glu 
    530                 535                 540                 


Val Ser Ser Ser Leu Gly Tyr Thr Ser Thr Arg Asp Val Leu Glu Asn 
545                 550                 555                 560 


Met Met Glu Pro Pro Gln Arg Asp Ser Ser Ala Pro Gly Arg Phe His 
                565                 570                 575     


Val Gly Ser Ala Glu Ser Met Leu His Val Arg Pro Gly Gly Tyr Thr 
            580                 585                 590         


Pro Gln Arg Ala Leu Ile Asn Pro Phe Ala Pro Ser Arg Met Pro Met 
        595                 600                 605             


Lys Leu Thr Ser Asn Arg Arg Arg Trp Met His Thr Phe Pro Val Gly 
    610                 615                 620                 


Pro Ser Gly Glu Ala Ile Gln Ile His His Gln Thr Arg Gln Asn Met 
625                 630                 635                 640 


Ala Glu Leu Gln Gly Ser Gly Gln Arg Asp Pro Thr His Ser Ser Ala 
                645                 650                 655     


Glu Leu Leu Glu Leu Ala Tyr His Glu Ala Ala Gly Arg His Ser Asn 
            660                 665                 670         


Ser Arg Gln Pro Gly Asp Gly Met Ser Phe Leu Asn Phe Ser Gly Thr 
        675                 680                 685             


Glu Glu Leu Ser Val Gly Leu Leu Ser Asn Ser Gly Ala Gly Met Asn 
    690                 695                 700                 


Pro Arg Thr Gln Asn Lys Asp Ser Leu Glu Asp Ser Val Ser Thr Ser 
705                 710                 715                 720 


Pro Asp Pro Ile Leu Thr Leu Ser Ala Pro Pro Val Val Pro Gly Phe 
                725                 730                 735     


Cys Cys Thr Val Gly Val Asp Trp Lys Ser Leu Thr Thr Pro Ala Cys 
            740                 745                 750         


Leu Pro Leu Thr Thr Asp Tyr Phe Pro Asp Arg Gln Gly Leu Gln Asn 
        755                 760                 765             


Asp Tyr Thr Glu Gly Cys Tyr Asp Leu Leu Pro Glu Ala Asp Ile Asp 
    770                 775                 780                 


Arg Arg Asp Glu Asp Gly Val Gln Met Thr Ala Gln Gln Val Phe Glu 
785                 790                 795                 800 


Glu Phe Ile Cys Gln Arg Leu Met Gln Gly Tyr Gln Ile Ile Val Gln 
                805                 810                 815     


Pro Lys Thr Gln Lys Pro Asn Pro Ala Val Pro Pro Pro Leu Ser Ser 
            820                 825                 830         


Ser Pro Leu Tyr Ser Arg Gly Leu Val Ser Arg Asn Arg Pro Glu Glu 
        835                 840                 845             


Glu Asp Gln Tyr Trp Leu Ser Met Gly Arg Thr Phe His Lys Val Thr 
    850                 855                 860                 


Leu Lys Asp Lys Met Ile Thr Val Thr Arg Tyr Leu Pro Lys Tyr Pro 
865                 870                 875                 880 


Tyr Glu Ser Ala Gln Ile His Tyr Thr Tyr Ser Leu Cys Pro Ser His 
                885                 890                 895     


Ser Asp Ser Glu Phe Val Ser Cys Trp Val Glu Phe Ser His Glu Arg 
            900                 905                 910         


Leu Glu Glu Tyr Lys Trp Asn Tyr Leu Asp Gln Tyr Ile Cys Ser Ala 
        915                 920                 925             


Gly Ser Glu Asp Phe Ser Leu Ile Glu Ser Leu Lys Phe Trp Arg Thr 
    930                 935                 940                 


Arg Phe Leu Leu Leu Pro Ala Cys Val Thr Ala Thr Lys Arg Ile Thr 
945                 950                 955                 960 


Glu Gly Glu Ala His Cys Asp Ile Tyr Gly Asp Arg Pro Arg Ala Asp 
                965                 970                 975     


Glu Asp Glu Trp Gln Leu Leu Asp Gly Phe Val Arg Phe Val Glu Gly 
            980                 985                 990         


Leu Asn Arg Ile Arg Arg Arg His  Arg Ser Asp Arg Met  Met Arg Lys 
        995                 1000                 1005             


Gly Thr  Ala Met Lys Gly Leu  Gln Met Thr Gly Pro  Ile Ser Thr 
    1010                 1015                 1020             


His Ser  Leu Glu Ser Thr Ala  Pro Pro Val Gly Lys  Lys Gly Thr 
    1025                 1030                 1035             


Ser Ala  Leu Ser Ala Leu Leu  Glu Met Glu Ala Ser  Gln Lys Cys 
    1040                 1045                 1050             


Leu Gly  Glu Gln Gln Ala Ala  Val His Gly Gly Lys  Ser Ser Ala 
    1055                 1060                 1065             


Gln Ser  Ala Glu Ser Ser Ser  Val Ala Met Thr Pro  Thr Tyr Met 
    1070                 1075                 1080             


Asp Ser  Pro Arg Lys Asp Gly  Ala Phe Phe Met Glu  Phe Val Arg 
    1085                 1090                 1095             


Ser Pro  Arg Thr Ala Ser Ser  Ala Phe Tyr Pro Gln  Val Ser Val 
    1100                 1105                 1110             


Asp Gln  Thr Ala Thr Pro Met  Leu Asp Gly Thr Ser  Leu Gly Ile 
    1115                 1120                 1125             


Cys Thr  Gly Gln Ser Met Asp  Arg Gly Asn Ser Gln  Thr Phe Gly 
    1130                 1135                 1140             


Asn Ser  Gln Asn Ile Gly Glu  Gln Gly Tyr Ser Ser  Thr Asn Ser 
    1145                 1150                 1155             


Ser Asp  Ser Ser Ser Gln Gln  Leu Val Ala Ser Ser  Leu Thr Ser 
    1160                 1165                 1170             


Ser Ser  Thr Leu Thr Glu Ile  Leu Glu Ala Met Lys  His Pro Ser 
    1175                 1180                 1185             


Thr Gly  Val Gln Leu Leu Ser  Glu Gln Lys Gly Leu  Ser Pro Tyr 
    1190                 1195                 1200             


Cys Phe  Ile Ser Ala Glu Val  Val His Trp Leu Val  Asn His Val 
    1205                 1210                 1215             


Glu Gly  Ile Gln Thr Gln Ala  Met Ala Ile Asp Ile  Met Gln Lys 
    1220                 1225                 1230             


Met Leu  Glu Glu Gln Leu Ile  Thr His Ala Ser Gly  Glu Ala Trp 
    1235                 1240                 1245             


Arg Thr  Phe Ile Tyr Gly Phe  Tyr Phe Tyr Lys Ile  Val Thr Asp 
    1250                 1255                 1260             


Lys Glu  Pro Asp Arg Val Ala  Met Gln Gln Pro Ala  Thr Thr Trp 
    1265                 1270                 1275             


His Thr  Ala Gly Val Asp Asp  Phe Ala Ser Phe Gln  Arg Lys Trp 
    1280                 1285                 1290             


Phe Glu  Val Ala Phe Val Ala  Glu Glu Leu Val His  Ser Glu Ile 
    1295                 1300                 1305             


Pro Ala  Phe Leu Leu Pro Trp  Leu Pro Ser Arg Pro  Ala Ser Tyr 
    1310                 1315                 1320             


Ala Ser  Arg His Ser Ser Phe  Ser Arg Ser Phe Gly  Gly Arg Ser 
    1325                 1330                 1335             


Gln Ala  Ala Ala Leu Leu Ala  Ala Thr Val Pro Glu  Gln Arg Thr 
    1340                 1345                 1350             


Val Thr  Leu Asp Val Asp Val  Asn Asn Arg Thr Asp  Arg Leu Glu 
    1355                 1360                 1365             


Trp Cys  Ser Cys Tyr Tyr His  Gly Asn Phe Ser Leu  Asn Ala Ala 
    1370                 1375                 1380             


Phe Glu  Ile Lys Leu His Trp  Met Ala Val Thr Ala  Ala Val Leu 
    1385                 1390                 1395             


Phe Glu  Met Val Gln Gly Trp  His Arg Lys Ala Thr  Ser Cys Gly 
    1400                 1405                 1410             


Phe Leu  Leu Val Pro Val Leu  Glu Gly Pro Phe Ala  Leu Pro Ser 
    1415                 1420                 1425             


Tyr Leu  Tyr Gly Asp Pro Leu  Arg Ala Gln Leu Phe  Ile Pro Leu 
    1430                 1435                 1440             


Asn Ile  Ser Cys Leu Leu Lys  Glu Gly Ser Glu His  Leu Phe Asp 
    1445                 1450                 1455             


Ser Phe  Glu Pro Glu Thr Tyr  Trp Asp Arg Met His  Leu Phe Gln 
    1460                 1465                 1470             


Glu Ala  Ile Ala His Arg Phe  Gly Phe Val Gln Asp  Lys Tyr Ser 
    1475                 1480                 1485             


Ala Ser  Ala Phe Asn Phe Pro  Ala Glu Asn Lys Pro  Gln Tyr Ile 
    1490                 1495                 1500             


His Val  Thr Gly Thr Val Phe  Leu Gln Leu Pro Tyr  Ser Lys Arg 
    1505                 1510                 1515             


Lys Phe  Ser Gly Gln Gln Arg  Arg Arg Arg Asn Ser  Thr Ser Ser 
    1520                 1525                 1530             


Thr Asn  Gln Asn Met Phe Cys  Glu Glu Arg Val Gly  Tyr Asn Trp 
    1535                 1540                 1545             


Ala Tyr  Asn Thr Met Leu Thr  Lys Thr Trp Arg Ser  Ser Ala Thr 
    1550                 1555                 1560             


Gly Asp  Glu Lys Phe Ala Asp  Arg Leu Leu Lys Asp  Phe Thr Asp 
    1565                 1570                 1575             


Phe Cys  Ile Asn Arg Asp Asn  Arg Leu Val Thr Phe  Trp Thr Ser 
    1580                 1585                 1590             


Cys Leu  Glu Lys Met His Ala  Ser Ala Pro 
    1595                 1600             


<210>  123
<211>  5551
<212>  DNA
<213>  Homo sapiens

<400>  123
ctagtaggcg cttcaggctt aggggcggaa cagcgcgggc cgcgcgggcg taggcggggt       60

atctggagga ggcgcaggga acctggagag ggtccagccc tcagtgcccc ggccagaggc      120

gggaaggggc tctagagctt cgggaggcaa gatgacttct ctgccccaag cttggaacag      180

ctaaagggaa aaacagtgca agatgagaac aacaaaggtc tacaaactcg tcatccacaa      240

gaagggcttt gggggcagtg atgatgagct agttgtgaac cccaaagtgt tccctcacat      300

caagcttgga gacattgtag agattgcaca ccccaacgat gaatacagcc ctctgctttt      360

gcaggtcaag tctcttaagg aagatttaca gaaggaaact atcagtgtgg accagactgt      420

gactcaagtg ttccggctga gaccttatca ggatgtctat gttaatgtcg tagaccctaa      480

ggatgtgacc cttgacctag tggaattaac ttttaaggat cagtatattg gccgtgggga      540

tatgtggcga ctaaagaaaa gtttggtcag cacatgtgcc tatatcaccc agaaggtgga      600

gtttgctggc atcagagcat aggctggtga actgtgggtt aagaatgaga aggtcatgtg      660

tggctacatc agtgaagata ccagggtggt gtttcgttct acgtcggcta tggtttacat      720

atttattcag atgagctgtg aaatgtggga ttttgatatt tatggggatt tgtattttga      780

gaaagctgtg aatggtttcc ttgctgatct atttaccaag tggaaggaga agaactgtag      840

tcatgaagtg acagtggtcc tgttttctag aactttctat gatgcaaaat ctgttgatga      900

atttcctgaa ataaaccgag cctcaattcg acaggatcac aaggggagat tctatgaaga      960

cttttacaaa gtggtggtgc agaatgagag aagagaagaa tggacttcac ttctcgtaac     1020

cattaaaaaa ctcttcatcc agtatccagt gttggtgcga ctggaacagg cagagggctt     1080

tcctcaagga gataattcta cctcagcaca aggaaactac ctggaggcca tcaatctgtc     1140

attcaatgtg tttgataagc actacatcaa ccgcaacttt gaccgaactg ggcagatgtc     1200

agtggtgatc acgcccgggg tgggtgtctt tgaagtggac cgcctactca tgatcctgac     1260

caagcagcgg atgatagata atggaattgg tgtggatttg gtgtgcatgg gagagcaacc     1320

gttacatgct gtcccattgt tcaagctcca taatcggagt gctccccgtg attctcgtct     1380

gggcgatgac tataatatcc ctcactggat aaaccacagt ttctacacat ccaaaagcca     1440

gctcttttgt aatagtttca ccccacgaat aaaactggca ggaaagaagc ccgcctctga     1500

gaaagcaaaa aatggccgtg atacatctct cgggagtcca aaagaatctg agaacgccct     1560

tcccatccaa gtagattatg acgcctatga cgctcaagtg ttcaggctgc ccggcccatc     1620

ccgggcccag tgcctcacca cctgcagatc tgtgcgagag cgagagagtc acagtcgaaa     1680

gagtgccagc tcctgtgatg tttcatccag cccttcccta ccaagccgca cactgcccac     1740

tgaggaagtg aggagccagg cttctgacga cagctcccta ggcaagagtg ccaacatcct     1800

gatgatccca cacccccacc tgcaccagta tgaagtcagc agctccttgg gatacaccag     1860

cactcgagat gtcctggaga acatgatgga gccaccacag cgagactcca gtgcaccagg     1920

gaggtttcac gttggcagtg cagaatccat gctgcatgtt cgacctggtg gatacacgcc     1980

ccagagagca ctgattaacc ccttcgctcc ctctcggatg cccatgaagc ttacgtccaa     2040

cagaaggcgc tggatgcaca cttttcctgt ggggccatcc ggagaagcca tccagatcca     2100

ccaccagacc cgacagaata tggcggagct acaaggcagc gggcagaggg atccaactca     2160

ctcctctgca gagctgctgg agttagcata tcatgaagct gctggaaggc acagcaattc     2220

ccgccagcct ggtgacggca tgtccttctt gaacttcagt ggaacagagg agctttctgt     2280

cggcctgctt agcaacagtg gtgcaggtat gaatcctagg acccagaata aggattctct     2340

agaggacagt gtttctacct ctccagaccc aattctgaca ctgtctgctc cccctgtagt     2400

gccaggcttc tgttgcacag ttggagtgga ctggaagtct ctcactactc cggcgtgcct     2460

cccccttacc accgactact tccctgaccg ccagggcctg cagaatgact acacagaggg     2520

ctgttatgat ctccttccag aagcagacat cgacaggagg gacgaagatg gtgtgcagat     2580

gacagcccag caggtatttg aagagtttat ttgccaacgt ctcatgcagg gctaccaaat     2640

catagtgcag cccaagacac agaaacccaa tcctgctgtc ccgcccccgc tgagcagtag     2700

cccactctat agccgaggcc ttgtgtcccg aaaccgccct gaggaggagg accagtattg     2760

gctgagtatg ggcagaacgt tccacaaagt gacgctgaag gataagatga tcacagtgac     2820

gcgatacctt cccaagtatc cttatgaatc tgcccagatc cactacacct acagcctctg     2880

tccttcccac tcagactcag agttcgtctc ctgctgggtg gaattctccc acgaacggct     2940

ggaggagtac aagtggaatt acttagatca gtatatctgt tctgccggct ctgaagactt     3000

cagcttaatt gagtccctga agttctggag gacccgcttc ctgctgctgc cagcctgtgt     3060

caccgccacc aagcgcatca cggaggggga ggcccactgc gacatctatg gggacaggcc     3120

ccgtgcagac gaggacgagt ggcaactcct ggatggtttt gtccgctttg tggagggctt     3180

gaatcgcatt cgcaggcggc atcgctcgga tcgcatgatg cggaaaggga ccgccatgaa     3240

aggcttgcag atgactgggc ccatttccac gcattctctg gagtcaactg cacccccagt     3300

ggggaagaag ggaacctcag ctctctctgc cctgttggag atggaggcca gtcagaagtg     3360

cctgggagaa cagcaggcag ctgtgcatgg tgggaagagc tccgcccagt cagccgagag     3420

cagcagcgtt gccatgactc ccacctacat ggacagccca cgaaaggacg gggccttctt     3480

tatggagttt gtccgcagcc cacgcacagc atcgtccgcc ttctaccctc aggtatctgt     3540

ggaccaaaca gccactccta tgttggacgg caccagtttg ggcatatgca caggccaatc     3600

catggacaga ggcaacagcc agacctttgg gaactcccag aacataggag aacagggcta     3660

ctcctccaca aactccagtg acagcagctc tcagcagctg gtggcaagct ccttgacctc     3720

atcctctacc ctgacagaga tcctggaagc catgaagcac ccctcgacag gagtccagct     3780

gctctctgaa cagaagggcc tctcaccgta ctgcttcatc agcgcggagg tggtacactg     3840

gttggtgaac cacgtggagg ggatccagac acaggcgatg gccattgaca tcatgcagaa     3900

aatgctggaa gagcagctca tcacacatgc atctggcgaa gcctggcgga ccttcatcta     3960

cggcttctat ttctacaaga tagtaacgga caaagagccc gaccgagtgg ccatgcagca     4020

gcccgccacc acctggcaca cagcaggagt ggacgacttc gccagcttcc agcgcaagtg     4080

gtttgaggtg gcctttgtgg cagaagagct cgtgcactct gagattcctg cctttctcct     4140

gccctggctg cctagccggc cagcctccta tgcaagtagg cacagctcct ttagccgaag     4200

ttttggagga cggagccagg cggcagcact tttagctgcc actgtcccag agcagaggac     4260

tgtgaccctg gatgttgacg tgaacaaccg cacagaccgg ctggagtggt gcagctgtta     4320

ttaccatggc aacttttctc tgaatgcagc ctttgagatc aagctgcact ggatggcggt     4380

gaccgcagca gtactcttcg agatggtcca aggttggcat cggaaagcca cctcctgtgg     4440

cttcttgtta gtcccagttt tggaggggcc ttttgcactg cccagttacc tgtatggcga     4500

cccccttcgt gcccagctct tcatcccact caacatcagc tgcttgctca aggagggcag     4560

cgagcacctg tttgatagct ttgaacccga aacgtactgg gatcgaatgc acctcttcca     4620

ggaagccatt gcacacaggt ttgggtttgt acaagataaa tattctgcct ctgcttttaa     4680

cttccctgct gagaacaagc ctcagtatat ccacgttaca ggaacagtgt ttctgcagct     4740

gccctactcc aagcgcaagt tctcagggca gcagcggcgg cggcggaact ccaccagctc     4800

caccaaccag aacatgttct gcgaggagcg ggtcggctac aactgggcct acaacaccat     4860

gctcaccaaa acatggcgct ccagcgccac aggggatgaa aagtttgctg atcggctgct     4920

gaaggacttc acggacttct gcatcaaccg tgacaaccgg ctggtcacgt tctggacaag     4980

ttgcctggag aagatgcatg ccagtgcccc gtgaggccag gctgcacctg tgctggggga     5040

aggtgggtga gccactgccc tcaaacccgg ggcggaggat tccaggcagg ctctaggagt     5100

caggtgtccg tttgctgcta tcagtgagtg ggggccattg ttttttgttt gtttgtttgt     5160

ttgtttgttt gtttttggcc cccacgacaa gtcttctact ctagaagaaa gactttggaa     5220

gcagctgctg ctgctgccac cactcctgtc agcaagtgct cagagcaggt gggaggcaca     5280

gattgtccgt gggagggctc cagtgtctgg gaagagggca ggcggccccc atgaatgtcc     5340

tcggaagggg gtggctcctg gtagcatcct tttccttcac catctatggg atattagggg     5400

cagaatctgc cacttcttgc ccaggagtgt gcacagatgt aagataattt tgtgaaataa     5460

tgtaccatag actctcacca actgtatata cctgtacata tcagaagcaa ataaagagct     5520

ccacgtgcat catttctttc cccacccagt t                                    5551


<210>  124
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Arg Thr Thr Lys Val Tyr Lys Leu Val Ile His Lys Lys Gly Phe 
1               5                   10                  15      


Gly Gly Ser Asp Asp Glu Leu Val Val Asn Pro Lys Val Phe Pro His 
            20                  25                  30          


Ile Lys Leu Gly Asp Ile Val Glu Ile Ala His Pro Asn Asp Glu Tyr 
        35                  40                  45              


Ser Pro Leu Leu Leu Gln Val Lys Ser Leu Lys Glu Asp Leu Gln Lys 
    50                  55                  60                  


Glu Thr Ile Ser Val Asp Gln Thr Val Thr Gln Val Phe Arg Leu Arg 
65                  70                  75                  80  


Pro Tyr Gln Asp Val Tyr Val Asn Val Val Asp Pro Lys Asp Val Thr 
                85                  90                  95      


Leu Asp Leu Val Glu Leu Thr Phe Lys Asp Gln Tyr Ile Gly Arg Gly 
            100                 105                 110         


Asp Met Trp Arg Leu Lys Lys Ser Leu Val Ser Thr Cys Ala Tyr Ile 
        115                 120                 125             


Thr Gln Lys Val Glu Phe Ala Gly Ile Arg Ala 
    130                 135                 


