                         SEQUENCE LISTING

<110>  GILBERT, Alan
       YANG, William C.
       LU, Jiuyi
       HUANG, Yao-Ming
 
<120>  METHODS FOR IMPROVED PRODUCTION AND RECOVERY OF RECOMBINANT 
       PROTEINS FROM EUKARYOTIC CELL CULTURES

<130>  2159.383PC02 - P0994 PC 000

<140>  00/000,000
<141>  2014-01-10

<150>  61/751.063
<151>  2013-01-10

<150>  61/889,922
<151>  2013-10-11

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Gly Gly Pro Gly Ser Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys 
1               5                   10                  15      


Arg Leu Arg Ser Gln Leu Val Pro Val Arg Ala Leu Gly Leu Gly His 
            20                  25                  30          


Arg Ser Asp Glu Leu Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg 
        35                  40                  45              


Arg Ala Arg Ser Pro His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala 
    50                  55                  60                  


Gly Ala Leu Arg Pro Pro Pro Gly Ser Arg Pro Val Ser Gln Pro Cys 
65                  70                  75                  80  


Cys Arg Pro Thr Arg Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser 
                85                  90                  95      


Thr Trp Arg Thr Val Asp Arg Leu Ser Ala Thr Ala Cys Gly Cys Leu 
            100                 105                 110         


Gly 
    


<210>  2
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Pro Asp Lys Gln Met Ala Val Leu Pro Arg Arg Glu Arg Asn Arg 
1               5                   10                  15      


Gln Ala Ala Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg 
            20                  25                  30          


Gly Gln Arg Gly Lys Asn Arg Gly Cys Val Leu Thr Ala Ile His Leu 
        35                  40                  45              


Asn Val Thr Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile 
    50                  55                  60                  


Phe Arg Tyr Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp 
65                  70                  75                  80  


Lys Ile Leu Lys Asn Leu Ser Arg Asn Arg Arg Leu Val Ser Asp Lys 
                85                  90                  95      


Val Gly Gln Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser 
            100                 105                 110         


Phe Leu Asp Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser Ala 
        115                 120                 125             


Lys Arg Cys Gly Cys Ile 
    130                 


<210>  3
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Arg Leu Gly Ala Arg Pro Cys Gly Leu Arg Glu Leu Glu Val Arg 
1               5                   10                  15      


Val Ser Glu Leu Gly Leu Gly Tyr Ala Ser Asp Glu Thr Val Leu Phe 
            20                  25                  30          


Arg Tyr Cys Ala Gly Ala Cys Glu Ala Ala Ala Arg Val Tyr Asp Leu 
        35                  40                  45              


Gly Leu Arg Arg Leu Arg Gln Arg Arg Arg Leu Arg Arg Glu Arg Val 
    50                  55                  60                  


Arg Ala Gln Pro Cys Cys Arg Pro Thr Ala Tyr Glu Asp Glu Val Ser 
65                  70                  75                  80  


Phe Leu Asp Ala His Ser Arg Tyr His Thr Val His Glu Leu Ser Ala 
                85                  90                  95      


Arg Glu Cys Ala Cys Val 
            100         


<210>  4
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Leu Ser Gly Pro Cys Gln Leu Trp Ser Leu Thr Leu Ser Val Ala 
1               5                   10                  15      


Glu Leu Gly Leu Gly Tyr Ala Ser Glu Glu Lys Val Ile Phe Arg Tyr 
            20                  25                  30          


Cys Ala Gly Ser Cys Pro Arg Gly Ala Arg Thr Gln His Gly Leu Ala 
        35                  40                  45              


Leu Ala Arg Leu Gln Gly Gln Gly Arg Ala His Gly Gly Pro Cys Cys 
    50                  55                  60                  


Arg Pro Thr Arg Tyr Thr Asp Val Ala Phe Leu Asp Asp Arg His Arg 
65                  70                  75                  80  


Trp Gln Arg Leu Pro Gln Leu Ser Ala Ala Ala Cys Gly Cys Gly Gly 
                85                  90                  95      


<210>  5
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Leu Gly Leu Gly Gly Leu Ser Thr Leu Ser His Cys Pro Trp 
1               5                   10                  15      


Pro Arg Arg Gln Pro Ala Leu Trp Pro Thr Leu Ala Ala Leu Ala Leu 
            20                  25                  30          


Leu Ser Ser Val Ala Glu Ala Ser Leu Gly Ser Ala Pro Arg Ser Pro 
        35                  40                  45              


Ala Pro Arg Glu Gly Pro Pro Pro Val Leu Ala Ser Pro Ala Gly His 
    50                  55                  60                  


Leu Pro Gly Gly Arg Thr Ala Arg Trp Cys Ser Gly Arg Ala Arg Arg 
65                  70                  75                  80  


Pro Pro Pro Gln Pro Ser Arg Pro Ala Pro Pro Pro Pro Ala Pro Pro 
                85                  90                  95      


Ser Ala Leu Pro Arg Gly Gly Arg Ala Ala Arg Ala Gly Gly Pro Gly 
            100                 105                 110         


Ser Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys Arg Leu Arg Ser Gln 
        115                 120                 125             


Leu Val Pro Val Arg Ala Leu Gly Leu Gly His Arg Ser Asp Glu Leu 
    130                 135                 140                 


Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg Arg Ala Arg Ser Pro 
145                 150                 155                 160 


His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala Gly Ala Leu Arg Pro 
                165                 170                 175     


Pro Pro Gly Ser Arg Pro Val Ser Gln Pro Cys Cys Arg Pro Thr Arg 
            180                 185                 190         


Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser Thr Trp Arg Thr Val 
        195                 200                 205             


Asp Arg Leu Ser Ala Thr Ala Cys Gly Cys Leu Gly 
    210                 215                 220 


<210>  6
<211>  224
<212>  PRT
<213>  Mus musculus

<400>  6

Met Glu Leu Gly Leu Ala Glu Pro Thr Ala Leu Ser His Cys Leu Arg 
1               5                   10                  15      


Pro Arg Trp Gln Ser Ala Trp Trp Pro Thr Leu Ala Val Leu Ala Leu 
            20                  25                  30          


Leu Ser Cys Val Thr Glu Ala Ser Leu Asp Pro Met Ser Arg Ser Pro 
        35                  40                  45              


Ala Ala Arg Asp Gly Pro Ser Pro Val Leu Ala Pro Pro Thr Asp His 
    50                  55                  60                  


Leu Pro Gly Gly His Thr Ala His Leu Cys Ser Glu Arg Thr Leu Arg 
65                  70                  75                  80  


Pro Pro Pro Gln Ser Pro Gln Pro Ala Pro Pro Pro Pro Gly Pro Ala 
                85                  90                  95      


Leu Gln Ser Pro Pro Ala Ala Leu Arg Gly Ala Arg Ala Ala Arg Ala 
            100                 105                 110         


Gly Thr Arg Ser Ser Arg Ala Arg Thr Thr Asp Ala Arg Gly Cys Arg 
        115                 120                 125             


Leu Arg Ser Gln Leu Val Pro Val Ser Ala Leu Gly Leu Gly His Ser 
    130                 135                 140                 


Ser Asp Glu Leu Ile Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg Arg 
145                 150                 155                 160 


Ala Arg Ser Gln His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala Gly 
                165                 170                 175     


Ala Leu Arg Ser Pro Pro Gly Ser Arg Pro Ile Ser Gln Pro Cys Cys 
            180                 185                 190         


Arg Pro Thr Arg Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser Thr 
        195                 200                 205             


Trp Arg Thr Val Asp His Leu Ser Ala Thr Ala Cys Gly Cys Leu Gly 
    210                 215                 220                 


<210>  7
<211>  224
<212>  PRT
<213>  Rattus norvegicus

<400>  7

Met Glu Leu Gly Leu Gly Glu Pro Thr Ala Leu Ser His Cys Leu Arg 
1               5                   10                  15      


Pro Arg Trp Gln Pro Ala Leu Trp Pro Thr Leu Ala Ala Leu Ala Leu 
            20                  25                  30          


Leu Ser Ser Val Thr Glu Ala Ser Leu Asp Pro Met Ser Arg Ser Pro 
        35                  40                  45              


Ala Ser Arg Asp Val Pro Ser Pro Val Leu Ala Pro Pro Thr Asp Tyr 
    50                  55                  60                  


Leu Pro Gly Gly His Thr Ala His Leu Cys Ser Glu Arg Thr Leu Arg 
65                  70                  75                  80  


Pro Pro Pro Gln Ser Pro Gln Pro Ala Pro Pro Pro Pro Gly Pro Ala 
                85                  90                  95      


Leu Gln Ser Pro Pro Ala Ala Leu Arg Gly Ala Arg Ala Ala Arg Ala 
            100                 105                 110         


Gly Thr Arg Ser Ser Arg Ala Arg Ala Thr Asp Ala Arg Gly Cys Arg 
        115                 120                 125             


Leu Arg Ser Gln Leu Val Pro Val Ser Ala Leu Gly Leu Gly His Ser 
    130                 135                 140                 


Ser Asp Glu Leu Ile Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg Arg 
145                 150                 155                 160 


Ala Arg Ser Pro His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala Gly 
                165                 170                 175     


Ala Leu Arg Ser Pro Pro Gly Ser Arg Pro Ile Ser Gln Pro Cys Cys 
            180                 185                 190         


Arg Pro Thr Arg Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser Thr 
        195                 200                 205             


Trp Arg Thr Val Asp His Leu Ser Ala Thr Ala Cys Gly Cys Leu Gly 
    210                 215                 220                 


<210>  8
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Pro Pro Glu Ala Pro 
            20                  25                  30          


Ala Glu Asp Arg Ser Leu Gly Arg Arg Arg Ala Pro Phe Ala Leu Ser 
        35                  40                  45              


Ser Asp Ser Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val 
    50                  55                  60                  


Met Asp Phe Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp 
65                  70                  75                  80  


Lys Gln Met Ala Val Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala Ala 
                85                  90                  95      


Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln Arg 
            100                 105                 110         


Gly Lys Asn Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr 
        115                 120                 125             


Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr 
    130                 135                 140                 


Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp Lys Ile Leu 
145                 150                 155                 160 


Lys Asn Leu Ser Arg Asn Arg Arg Leu Val Ser Asp Lys Val Gly Gln 
                165                 170                 175     


Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp 
            180                 185                 190         


Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys 
        195                 200                 205             


Gly Cys Ile 
    210     


<210>  9
<211>  240
<212>  PRT
<213>  Mus musculus

<400>  9

Met Gly Phe Gly Pro Leu Gly Val Asn Val Gln Leu Gly Val Tyr Gly 
1               5                   10                  15      


Asp Arg Ile Arg Gly Ala Ala Ala Gly Arg Asp Ser Lys Met Lys Leu 
            20                  25                  30          


Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr Ala Ser Ala 
        35                  40                  45              


Phe Pro Leu Pro Ala Gly Lys Arg Leu Leu Glu Ala Pro Ala Glu Asp 
    50                  55                  60                  


His Ser Leu Gly His Arg Arg Val Pro Phe Ala Leu Thr Ser Asp Ser 
65                  70                  75                  80  


Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val Met Asp Phe 
                85                  90                  95      


Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp Lys Gln Ala 
            100                 105                 110         


Ala Ala Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala Ala Ala Ala Ser 
        115                 120                 125             


Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln Arg Gly Lys Asn 
    130                 135                 140                 


Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr Asp Leu Gly 
145                 150                 155                 160 


Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr Cys Ser Gly 
                165                 170                 175     


Ser Cys Glu Ser Ala Glu Thr Met Tyr Asp Lys Ile Leu Lys Asn Leu 
            180                 185                 190         


Ser Arg Ser Arg Arg Leu Thr Ser Asp Lys Val Gly Gln Ala Cys Cys 
        195                 200                 205             


Arg Pro Val Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp Asp Asn Leu 
    210                 215                 220                 


Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys Gly Cys Ile 
225                 230                 235                 240 


<210>  10
<211>  211
<212>  PRT
<213>  Rattus norvegicus

<400>  10

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Leu Leu Glu Ala Pro 
            20                  25                  30          


Ala Glu Asp His Ser Leu Gly His Arg Arg Val Pro Phe Ala Leu Thr 
        35                  40                  45              


Ser Asp Ser Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val 
    50                  55                  60                  


Met Asp Phe Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp 
65                  70                  75                  80  


Lys Gln Ala Ala Ala Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala Ala 
                85                  90                  95      


Ala Ala Ser Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln Arg 
            100                 105                 110         


Gly Lys Asn Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr 
        115                 120                 125             


Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr 
    130                 135                 140                 


Cys Ser Gly Ser Cys Glu Ala Ala Glu Thr Met Tyr Asp Lys Ile Leu 
145                 150                 155                 160 


Lys Asn Leu Ser Arg Ser Arg Arg Leu Thr Ser Asp Lys Val Gly Gln 
                165                 170                 175     


Ala Cys Cys Arg Pro Val Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp 
            180                 185                 190         


Asp Ser Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys 
        195                 200                 205             


Gly Cys Ile 
    210     


<210>  11
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gln Arg Trp Lys Ala Ala Ala Leu Ala Ser Val Leu Cys Ser Ser 
1               5                   10                  15      


Val Leu Ser Ile Trp Met Cys Arg Glu Gly Leu Leu Leu Ser His Arg 
            20                  25                  30          


Leu Gly Pro Ala Leu Val Pro Leu His Arg Leu Pro Arg Thr Leu Asp 
        35                  40                  45              


Ala Arg Ile Ala Arg Leu Ala Gln Tyr Arg Ala Leu Leu Gln Gly Ala 
    50                  55                  60                  


Met Pro Asp Ala Met Glu Leu Arg Glu Leu Thr Pro Trp Ala Gly Arg 
65                  70                  75                  80  


Pro Pro Gly Pro Arg Arg Arg Ala Gly Pro Arg Arg Arg Arg Ala Arg 
                85                  90                  95      


Ala Arg Leu Gly Ala Arg Pro Cys Gly Leu Arg Glu Leu Glu Val Arg 
            100                 105                 110         


Val Ser Glu Leu Gly Leu Gly Tyr Ala Ser Asp Glu Thr Val Leu Phe 
        115                 120                 125             


Arg Tyr Cys Ala Gly Ala Cys Glu Ala Ala Ala Arg Val Tyr Asp Leu 
    130                 135                 140                 


Gly Leu Arg Arg Leu Arg Gln Arg Arg Arg Leu Arg Arg Glu Arg Val 
145                 150                 155                 160 


Arg Ala Gln Pro Cys Cys Arg Pro Thr Ala Tyr Glu Asp Glu Val Ser 
                165                 170                 175     


Phe Leu Asp Ala His Ser Arg Tyr His Thr Val His Glu Leu Ser Ala 
            180                 185                 190         


Arg Glu Cys Ala Cys Val 
        195             


<210>  12
<211>  195
<212>  PRT
<213>  Mus musculus

<400>  12

Met Arg Arg Trp Lys Ala Ala Ala Leu Val Ser Leu Ile Cys Ser Ser 
1               5                   10                  15      


Leu Leu Ser Val Trp Met Cys Gln Glu Gly Leu Leu Leu Gly His Arg 
            20                  25                  30          


Leu Gly Pro Ala Leu Ala Pro Leu Arg Arg Pro Pro Arg Thr Leu Asp 
        35                  40                  45              


Ala Arg Ile Ala Arg Leu Ala Gln Tyr Arg Ala Leu Leu Gln Gly Ala 
    50                  55                  60                  


Pro Asp Ala Val Glu Leu Arg Glu Leu Ser Pro Trp Ala Ala Arg Ile 
65                  70                  75                  80  


Pro Gly Pro Arg Arg Arg Ala Gly Pro Arg Arg Arg Arg Ala Arg Pro 
                85                  90                  95      


Gly Ala Arg Pro Cys Gly Leu Arg Glu Leu Glu Val Arg Val Ser Glu 
            100                 105                 110         


Leu Gly Leu Gly Tyr Thr Ser Asp Glu Thr Val Leu Phe Arg Tyr Cys 
        115                 120                 125             


Ala Gly Ala Cys Glu Ala Ala Ile Arg Ile Tyr Asp Leu Gly Leu Arg 
    130                 135                 140                 


Arg Leu Arg Gln Arg Arg Arg Val Arg Arg Glu Arg Ala Arg Ala His 
145                 150                 155                 160 


Pro Cys Cys Arg Pro Thr Ala Tyr Glu Asp Glu Val Ser Phe Leu Asp 
                165                 170                 175     


Val His Ser Arg Tyr His Thr Leu Gln Glu Leu Ser Ala Arg Glu Cys 
            180                 185                 190         


Ala Cys Val 
        195 


<210>  13
<211>  195
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Met Arg Cys Trp Lys Ala Ala Ala Leu Val Ser Leu Ile Cys Ser Ser 
1               5                   10                  15      


Leu Leu Ser Val Trp Met Cys Gln Glu Gly Leu Leu Leu Gly His Arg 
            20                  25                  30          


Leu Gly Pro Ala Leu Ala Pro Leu Arg Arg Pro Pro Arg Thr Leu Asp 
        35                  40                  45              


Ala Arg Ile Ala Arg Leu Ala Gln Tyr Arg Ala Leu Leu Gln Gly Ala 
    50                  55                  60                  


Pro Asp Ala Val Glu Leu Arg Glu Leu Ser Pro Trp Val Ala Arg Pro 
65                  70                  75                  80  


Ser Gly Pro Arg Arg Arg Ala Gly Pro Arg Arg Arg Arg Ala Arg Pro 
                85                  90                  95      


Gly Ser Arg Pro Cys Gly Leu Arg Glu Leu Glu Val Arg Val Ser Glu 
            100                 105                 110         


Leu Gly Leu Gly Tyr Thr Ser Asp Glu Thr Val Leu Phe Arg Tyr Cys 
        115                 120                 125             


Ala Gly Ala Cys Glu Ala Ala Ile Arg Ile Tyr Asp Leu Gly Leu Arg 
    130                 135                 140                 


Arg Leu Arg Gln Arg Arg Arg Val Arg Lys Glu Arg Val Arg Ala His 
145                 150                 155                 160 


Pro Cys Cys Arg Pro Thr Ala Tyr Glu Asp Glu Val Ser Phe Leu Asp 
                165                 170                 175     


Val His Ser Arg Tyr His Thr Leu Gln Glu Leu Ser Ala Arg Glu Cys 
            180                 185                 190         


Ala Cys Val 
        195 


<210>  14
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Val Gly Lys Phe Leu Leu Gly Ser Leu Leu Leu Leu Ser Leu 
1               5                   10                  15      


Gln Leu Gly Gln Gly Trp Gly Pro Asp Ala Arg Gly Val Pro Val Ala 
            20                  25                  30          


Asp Gly Glu Phe Ser Ser Glu Gln Val Ala Lys Ala Gly Gly Thr Trp 
        35                  40                  45              


Leu Gly Thr His Arg Pro Leu Ala Arg Leu Arg Arg Ala Leu Ser Gly 
    50                  55                  60                  


Pro Cys Gln Leu Trp Ser Leu Thr Leu Ser Val Ala Glu Leu Gly Leu 
65                  70                  75                  80  


Gly Tyr Ala Ser Glu Glu Lys Val Ile Phe Arg Tyr Cys Ala Gly Ser 
                85                  90                  95      


Cys Pro Arg Gly Ala Arg Thr Gln His Gly Leu Ala Leu Ala Arg Leu 
            100                 105                 110         


Gln Gly Gln Gly Arg Ala His Gly Gly Pro Cys Cys Arg Pro Thr Arg 
        115                 120                 125             


Tyr Thr Asp Val Ala Phe Leu Asp Asp Arg His Arg Trp Gln Arg Leu 
    130                 135                 140                 


Pro Gln Leu Ser Ala Ala Ala Cys Gly Cys Gly Gly 
145                 150                 155     


<210>  15
<211>  156
<212>  PRT
<213>  Mus musculus

<400>  15

Met Ala Ala Gly Arg Leu Arg Ile Leu Cys Leu Leu Leu Leu Ser Leu 
1               5                   10                  15      


His Pro Ser Leu Gly Trp Val Leu Asp Leu Gln Glu Ala Ser Val Ala 
            20                  25                  30          


Asp Lys Leu Ser Phe Gly Lys Met Ala Glu Thr Arg Gly Thr Trp Thr 
        35                  40                  45              


Pro His Gln Gly Asn Asn His Val Arg Leu Pro Arg Ala Leu Ala Gly 
    50                  55                  60                  


Ser Cys Arg Leu Trp Ser Leu Thr Leu Pro Val Ala Glu Leu Gly Leu 
65                  70                  75                  80  


Gly Tyr Ala Ser Glu Glu Lys Val Ile Phe Arg Tyr Cys Ala Gly Ser 
                85                  90                  95      


Cys Pro Gln Glu Ala Arg Thr Gln His Ser Leu Val Leu Ala Arg Leu 
            100                 105                 110         


Arg Gly Arg Gly Arg Ala His Gly Arg Pro Cys Cys Gln Pro Thr Ser 
        115                 120                 125             


Tyr Ala Asp Val Thr Phe Leu Asp Asp Gln His His Trp Gln Gln Leu 
    130                 135                 140                 


Pro Gln Leu Ser Ala Ala Ala Cys Gly Cys Gly Gly 
145                 150                 155     


<210>  16
<211>  156
<212>  PRT
<213>  Rattus norvegicus

<400>  16

Met Ala Ala Gly Arg Leu Arg Ile Leu Phe Leu Leu Leu Leu Ser Leu 
1               5                   10                  15      


His Leu Gly Leu Gly Trp Val Leu Asp Leu Gln Glu Ala Pro Ala Ala 
            20                  25                  30          


Asp Glu Leu Ser Ser Gly Lys Met Ala Glu Thr Gly Arg Thr Trp Lys 
        35                  40                  45              


Pro His Gln Gly Asn Asn Asn Val Arg Leu Pro Arg Ala Leu Pro Gly 
    50                  55                  60                  


Leu Cys Arg Leu Trp Ser Leu Thr Leu Pro Val Ala Glu Leu Gly Leu 
65                  70                  75                  80  


Gly Tyr Ala Ser Glu Glu Lys Ile Ile Phe Arg Tyr Cys Ala Gly Ser 
                85                  90                  95      


Cys Pro Gln Glu Val Arg Thr Gln His Ser Leu Val Leu Ala Arg Leu 
            100                 105                 110         


Arg Gly Gln Gly Arg Ala His Gly Arg Pro Cys Cys Gln Pro Thr Ser 
        115                 120                 125             


Tyr Ala Asp Val Thr Phe Leu Asp Asp His His His Trp Gln Gln Leu 
    130                 135                 140                 


Pro Gln Leu Ser Ala Ala Ala Cys Gly Cys Gly Gly 
145                 150                 155     


<210>  17
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  17

Pro Pro Pro Gln Pro Ser Arg Pro Ala Pro Pro Pro Pro Ala Pro Pro 
1               5                   10                  15      


Ser Ala Leu Pro Arg Gly Gly Arg Ala Ala Arg Ala Gly Gly Pro Gly 
            20                  25                  30          


Ser Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys Arg Leu Arg Ser Gln 
        35                  40                  45              


Leu Val Pro Val Arg Ala Leu Gly Leu Gly His Arg Ser Asp Glu Leu 
    50                  55                  60                  


Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg Arg Ala Arg Ser Pro 
65                  70                  75                  80  


His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala Gly Ala Leu Arg Pro 
                85                  90                  95      


Pro Pro Gly Ser Arg Pro Val Ser Gln Pro Cys Cys Arg Pro Thr Arg 
            100                 105                 110         


Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser Thr Trp Arg Thr Val 
        115                 120                 125             


Asp Arg Leu Ser Ala Thr Ala Cys Gly Cys Leu Gly 
    130                 135                 140 


<210>  18
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  18

Ala Ala Arg Ala Gly Gly Pro Gly Ser Arg Ala Arg Ala Ala Gly Ala 
1               5                   10                  15      


Arg Gly Cys Arg Leu Arg Ser Gln Leu Val Pro Val Arg Ala Leu Gly 
            20                  25                  30          


Leu Gly His Arg Ser Asp Glu Leu Val Arg Phe Arg Phe Cys Ser Gly 
        35                  40                  45              


Ser Cys Arg Arg Ala Arg Ser Pro His Asp Leu Ser Leu Ala Ser Leu 
    50                  55                  60                  


Leu Gly Ala Gly Ala Leu Arg Pro Pro Pro Gly Ser Arg Pro Val Ser 
65                  70                  75                  80  


Gln Pro Cys Cys Arg Pro Thr Arg Tyr Glu Ala Val Ser Phe Met Asp 
                85                  90                  95      


Val Asn Ser Thr Trp Arg Thr Val Asp Arg Leu Ser Ala Thr Ala Cys 
            100                 105                 110         


Gly Cys Leu Gly 
        115     


<210>  19
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  19

Gly Gly Pro Gly Ser Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys Arg 
1               5                   10                  15      


Leu Arg Ser Gln Leu Val Pro Val Arg Ala Leu Gly Leu Gly His Arg 
            20                  25                  30          


Ser Asp Glu Leu Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg Arg 
        35                  40                  45              


Ala Arg Ser Pro His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala Gly 
    50                  55                  60                  


Ala Leu Arg Pro Pro Pro Gly Ser Arg Pro Val Ser Gln Pro Cys Cys 
65                  70                  75                  80  


Arg Pro Thr Arg Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser Thr 
                85                  90                  95      


Trp Arg Thr Val Asp Arg Leu Ser Ala Thr Ala Cys Gly Cys Leu Gly 
            100                 105                 110         


<210>  20
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  20

Gly Pro Gly Ser Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys Arg Leu 
1               5                   10                  15      


Arg Ser Gln Leu Val Pro Val Arg Ala Leu Gly Leu Gly His Arg Ser 
            20                  25                  30          


Asp Glu Leu Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg Arg Ala 
        35                  40                  45              


Arg Ser Pro His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala Gly Ala 
    50                  55                  60                  


Leu Arg Pro Pro Pro Gly Ser Arg Pro Val Ser Gln Pro Cys Cys Arg 
65                  70                  75                  80  


Pro Thr Arg Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser Thr Trp 
                85                  90                  95      


Arg Thr Val Asp Arg Leu Ser Ala Thr Ala Cys Gly Cys Leu Gly 
            100                 105                 110     


<210>  21
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  21

Pro Gly Ser Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys Arg Leu Arg 
1               5                   10                  15      


Ser Gln Leu Val Pro Val Arg Ala Leu Gly Leu Gly His Arg Ser Asp 
            20                  25                  30          


Glu Leu Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg Arg Ala Arg 
        35                  40                  45              


Ser Pro His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala Gly Ala Leu 
    50                  55                  60                  


Arg Pro Pro Pro Gly Ser Arg Pro Val Ser Gln Pro Cys Cys Arg Pro 
65                  70                  75                  80  


Thr Arg Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser Thr Trp Arg 
                85                  90                  95      


Thr Val Asp Arg Leu Ser Ala Thr Ala Cys Gly Cys Leu Gly 
            100                 105                 110 


<210>  22
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  22

Gly Ser Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys Arg Leu Arg Ser 
1               5                   10                  15      


Gln Leu Val Pro Val Arg Ala Leu Gly Leu Gly His Arg Ser Asp Glu 
            20                  25                  30          


Leu Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg Arg Ala Arg Ser 
        35                  40                  45              


Pro His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala Gly Ala Leu Arg 
    50                  55                  60                  


Pro Pro Pro Gly Ser Arg Pro Val Ser Gln Pro Cys Cys Arg Pro Thr 
65                  70                  75                  80  


Arg Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser Thr Trp Arg Thr 
                85                  90                  95      


Val Asp Arg Leu Ser Ala Thr Ala Cys Gly Cys Leu Gly 
            100                 105                 


<210>  23
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  23

Ser Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys Arg Leu Arg Ser Gln 
1               5                   10                  15      


Leu Val Pro Val Arg Ala Leu Gly Leu Gly His Arg Ser Asp Glu Leu 
            20                  25                  30          


Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg Arg Ala Arg Ser Pro 
        35                  40                  45              


His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala Gly Ala Leu Arg Pro 
    50                  55                  60                  


Pro Pro Gly Ser Arg Pro Val Ser Gln Pro Cys Cys Arg Pro Thr Arg 
65                  70                  75                  80  


Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser Thr Trp Arg Thr Val 
                85                  90                  95      


Asp Arg Leu Ser Ala Thr Ala Cys Gly Cys Leu Gly 
            100                 105             


<210>  24
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  24

Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys Arg Leu Arg Ser Gln Leu 
1               5                   10                  15      


Val Pro Val Arg Ala Leu Gly Leu Gly His Arg Ser Asp Glu Leu Val 
            20                  25                  30          


Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg Arg Ala Arg Ser Pro His 
        35                  40                  45              


Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala Gly Ala Leu Arg Pro Pro 
    50                  55                  60                  


Pro Gly Ser Arg Pro Val Ser Gln Pro Cys Cys Arg Pro Thr Arg Tyr 
65                  70                  75                  80  


Glu Ala Val Ser Phe Met Asp Val Asn Ser Thr Trp Arg Thr Val Asp 
                85                  90                  95      


Arg Leu Ser Ala Thr Ala Cys Gly Cys Leu Gly 
            100                 105         


<210>  25
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  25

Ala Arg Ala Ala Gly Ala Arg Gly Cys Arg Leu Arg Ser Gln Leu Val 
1               5                   10                  15      


Pro Val Arg Ala Leu Gly Leu Gly His Arg Ser Asp Glu Leu Val Arg 
            20                  25                  30          


Phe Arg Phe Cys Ser Gly Ser Cys Arg Arg Ala Arg Ser Pro His Asp 
        35                  40                  45              


Leu Ser Leu Ala Ser Leu Leu Gly Ala Gly Ala Leu Arg Pro Pro Pro 
    50                  55                  60                  


Gly Ser Arg Pro Val Ser Gln Pro Cys Cys Arg Pro Thr Arg Tyr Glu 
65                  70                  75                  80  


Ala Val Ser Phe Met Asp Val Asn Ser Thr Trp Arg Thr Val Asp Arg 
                85                  90                  95      


Leu Ser Ala Thr Ala Cys Gly Cys Leu Gly 
            100                 105     


<210>  26
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  26

Arg Ala Ala Gly Ala Arg Gly Cys Arg Leu Arg Ser Gln Leu Val Pro 
1               5                   10                  15      


Val Arg Ala Leu Gly Leu Gly His Arg Ser Asp Glu Leu Val Arg Phe 
            20                  25                  30          


Arg Phe Cys Ser Gly Ser Cys Arg Arg Ala Arg Ser Pro His Asp Leu 
        35                  40                  45              


Ser Leu Ala Ser Leu Leu Gly Ala Gly Ala Leu Arg Pro Pro Pro Gly 
    50                  55                  60                  


Ser Arg Pro Val Ser Gln Pro Cys Cys Arg Pro Thr Arg Tyr Glu Ala 
65                  70                  75                  80  


Val Ser Phe Met Asp Val Asn Ser Thr Trp Arg Thr Val Asp Arg Leu 
                85                  90                  95      


Ser Ala Thr Ala Cys Gly Cys Leu Gly 
            100                 105 


<210>  27
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  27

Ala Ala Gly Ala Arg Gly Cys Arg Leu Arg Ser Gln Leu Val Pro Val 
1               5                   10                  15      


Arg Ala Leu Gly Leu Gly His Arg Ser Asp Glu Leu Val Arg Phe Arg 
            20                  25                  30          


Phe Cys Ser Gly Ser Cys Arg Arg Ala Arg Ser Pro His Asp Leu Ser 
        35                  40                  45              


Leu Ala Ser Leu Leu Gly Ala Gly Ala Leu Arg Pro Pro Pro Gly Ser 
    50                  55                  60                  


Arg Pro Val Ser Gln Pro Cys Cys Arg Pro Thr Arg Tyr Glu Ala Val 
65                  70                  75                  80  


Ser Phe Met Asp Val Asn Ser Thr Trp Arg Thr Val Asp Arg Leu Ser 
                85                  90                  95      


Ala Thr Ala Cys Gly Cys Leu Gly 
            100                 


<210>  28
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  28

Ala Gly Ala Arg Gly Cys Arg Leu Arg Ser Gln Leu Val Pro Val Arg 
1               5                   10                  15      


Ala Leu Gly Leu Gly His Arg Ser Asp Glu Leu Val Arg Phe Arg Phe 
            20                  25                  30          


Cys Ser Gly Ser Cys Arg Arg Ala Arg Ser Pro His Asp Leu Ser Leu 
        35                  40                  45              


Ala Ser Leu Leu Gly Ala Gly Ala Leu Arg Pro Pro Pro Gly Ser Arg 
    50                  55                  60                  


Pro Val Ser Gln Pro Cys Cys Arg Pro Thr Arg Tyr Glu Ala Val Ser 
65                  70                  75                  80  


Phe Met Asp Val Asn Ser Thr Trp Arg Thr Val Asp Arg Leu Ser Ala 
                85                  90                  95      


Thr Ala Cys Gly Cys Leu Gly 
            100             


<210>  29
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  29

Gly Ala Arg Gly Cys Arg Leu Arg Ser Gln Leu Val Pro Val Arg Ala 
1               5                   10                  15      


Leu Gly Leu Gly His Arg Ser Asp Glu Leu Val Arg Phe Arg Phe Cys 
            20                  25                  30          


Ser Gly Ser Cys Arg Arg Ala Arg Ser Pro His Asp Leu Ser Leu Ala 
        35                  40                  45              


Ser Leu Leu Gly Ala Gly Ala Leu Arg Pro Pro Pro Gly Ser Arg Pro 
    50                  55                  60                  


Val Ser Gln Pro Cys Cys Arg Pro Thr Arg Tyr Glu Ala Val Ser Phe 
65                  70                  75                  80  


Met Asp Val Asn Ser Thr Trp Arg Thr Val Asp Arg Leu Ser Ala Thr 
                85                  90                  95      


Ala Cys Gly Cys Leu Gly 
            100         


<210>  30
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  30

Ala Arg Gly Cys Arg Leu Arg Ser Gln Leu Val Pro Val Arg Ala Leu 
1               5                   10                  15      


Gly Leu Gly His Arg Ser Asp Glu Leu Val Arg Phe Arg Phe Cys Ser 
            20                  25                  30          


Gly Ser Cys Arg Arg Ala Arg Ser Pro His Asp Leu Ser Leu Ala Ser 
        35                  40                  45              


Leu Leu Gly Ala Gly Ala Leu Arg Pro Pro Pro Gly Ser Arg Pro Val 
    50                  55                  60                  


Ser Gln Pro Cys Cys Arg Pro Thr Arg Tyr Glu Ala Val Ser Phe Met 
65                  70                  75                  80  


Asp Val Asn Ser Thr Trp Arg Thr Val Asp Arg Leu Ser Ala Thr Ala 
                85                  90                  95      


Cys Gly Cys Leu Gly 
            100     


<210>  31
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  31

Arg Gly Cys Arg Leu Arg Ser Gln Leu Val Pro Val Arg Ala Leu Gly 
1               5                   10                  15      


Leu Gly His Arg Ser Asp Glu Leu Val Arg Phe Arg Phe Cys Ser Gly 
            20                  25                  30          


Ser Cys Arg Arg Ala Arg Ser Pro His Asp Leu Ser Leu Ala Ser Leu 
        35                  40                  45              


Leu Gly Ala Gly Ala Leu Arg Pro Pro Pro Gly Ser Arg Pro Val Ser 
    50                  55                  60                  


Gln Pro Cys Cys Arg Pro Thr Arg Tyr Glu Ala Val Ser Phe Met Asp 
65                  70                  75                  80  


Val Asn Ser Thr Trp Arg Thr Val Asp Arg Leu Ser Ala Thr Ala Cys 
                85                  90                  95      


Gly Cys Leu Gly 
            100 


<210>  32
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  32

Gly Cys Arg Leu Arg Ser Gln Leu Val Pro Val Arg Ala Leu Gly Leu 
1               5                   10                  15      


Gly His Arg Ser Asp Glu Leu Val Arg Phe Arg Phe Cys Ser Gly Ser 
            20                  25                  30          


Cys Arg Arg Ala Arg Ser Pro His Asp Leu Ser Leu Ala Ser Leu Leu 
        35                  40                  45              


Gly Ala Gly Ala Leu Arg Pro Pro Pro Gly Ser Arg Pro Val Ser Gln 
    50                  55                  60                  


Pro Cys Cys Arg Pro Thr Arg Tyr Glu Ala Val Ser Phe Met Asp Val 
65                  70                  75                  80  


Asn Ser Thr Trp Arg Thr Val Asp Arg Leu Ser Ala Thr Ala Cys Gly 
                85                  90                  95      


Cys Leu Gly 
            


<210>  33
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  33

Ala Gly Gly Pro Gly Ser Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys 
1               5                   10                  15      


Arg Leu Arg Ser Gln Leu Val Pro Val Arg Ala Leu Gly Leu Gly His 
            20                  25                  30          


Arg Ser Asp Glu Leu Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Glu 
        35                  40                  45              


Arg Ala Arg Ser Pro His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala 
    50                  55                  60                  


Gly Ala Leu Arg Pro Pro Pro Gly Ser Arg Pro Val Ser Gln Pro Cys 
65                  70                  75                  80  


Cys Arg Pro Thr Arg Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser 
                85                  90                  95      


Thr Trp Arg Thr Val Asp Arg Leu Ser Ala Thr Ala Cys Gly Cys Leu 
            100                 105                 110         


Gly 
    


<210>  34
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  34

Ala Gly Gly Pro Gly Ser Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys 
1               5                   10                  15      


Arg Leu Arg Ser Gln Leu Val Pro Val Arg Ala Leu Gly Leu Gly His 
            20                  25                  30          


Arg Ser Asp Glu Leu Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg 
        35                  40                  45              


Glu Ala Arg Ser Pro His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala 
    50                  55                  60                  


Gly Ala Leu Arg Pro Pro Pro Gly Ser Arg Pro Val Ser Gln Pro Cys 
65                  70                  75                  80  


Cys Arg Pro Thr Arg Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser 
                85                  90                  95      


Thr Trp Arg Thr Val Asp Arg Leu Ser Ala Thr Ala Cys Gly Cys Leu 
            100                 105                 110         


Gly 
    


<210>  35
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  35

Ala Gly Gly Pro Gly Ser Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys 
1               5                   10                  15      


Arg Leu Arg Ser Gln Leu Val Pro Val Arg Ala Leu Gly Leu Gly His 
            20                  25                  30          


Arg Ser Asp Glu Leu Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg 
        35                  40                  45              


Arg Ala Glu Ser Pro His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala 
    50                  55                  60                  


Gly Ala Leu Arg Pro Pro Pro Gly Ser Arg Pro Val Ser Gln Pro Cys 
65                  70                  75                  80  


Cys Arg Pro Thr Arg Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser 
                85                  90                  95      


Thr Trp Arg Thr Val Asp Arg Leu Ser Ala Thr Ala Cys Gly Cys Leu 
            100                 105                 110         


Gly 
    


<210>  36
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  36

Ala Gly Gly Pro Gly Ser Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys 
1               5                   10                  15      


Arg Leu Arg Ser Gln Leu Val Pro Val Arg Ala Leu Gly Leu Gly His 
            20                  25                  30          


Arg Ser Asp Glu Leu Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Glu 
        35                  40                  45              


Glu Ala Arg Ser Pro His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala 
    50                  55                  60                  


Gly Ala Leu Arg Pro Pro Pro Gly Ser Arg Pro Val Ser Gln Pro Cys 
65                  70                  75                  80  


Cys Arg Pro Thr Arg Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser 
                85                  90                  95      


Thr Trp Arg Thr Val Asp Arg Leu Ser Ala Thr Ala Cys Gly Cys Leu 
            100                 105                 110         


Gly 
    


<210>  37
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  37

Gly Cys Arg Leu Arg Ser Gln Leu Val Pro Val Arg Ala Leu Gly Leu 
1               5                   10                  15      


Gly His Arg Ser Asp Glu Leu Val Arg Phe Arg Phe Cys Ser Gly Ser 
            20                  25                  30          


Cys Glu Glu Ala Arg Ser Pro His Asp Leu Ser Leu Ala Ser Leu Leu 
        35                  40                  45              


Gly Ala Gly Ala Leu Arg Pro Pro Pro Gly Ser Arg Pro Val Ser Gln 
    50                  55                  60                  


Pro Cys Cys Arg Pro Thr Arg Tyr Glu Ala Val Ser Phe Met Asp Val 
65                  70                  75                  80  


Asn Ser Thr Trp Arg Thr Val Asp Arg Leu Ser Ala Thr Ala Cys Gly 
                85                  90                  95      


Cys Leu Gly 
            


<210>  38
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  38

Ala Ala Gly Ala Arg Gly Cys Arg Leu Arg Ser Gln Leu Val Pro Val 
1               5                   10                  15      


Arg Ala Leu Gly Leu Gly His Arg Ser Asp Glu Leu Val Arg Phe Arg 
            20                  25                  30          


Phe Cys Ser Gly Ser Cys Glu Glu Ala Arg Ser Pro His Asp Leu Ser 
        35                  40                  45              


Leu Ala Ser Leu Leu Gly Ala Gly Ala Leu Arg Pro Pro Pro Gly Ser 
    50                  55                  60                  


Arg Pro Val Ser Gln Pro Cys Cys Arg Pro Thr Arg Tyr Glu Ala Val 
65                  70                  75                  80  


Ser Phe Met Asp Val Asn Ser Thr Trp Arg Thr Val Asp Arg Leu Ser 
                85                  90                  95      


Ala Thr Ala Cys Gly Cys Leu Gly 
            100                 


<210>  39
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  39

Ala Gly Gly Pro Gly Ser Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys 
1               5                   10                  15      


Arg Leu Arg Ser Gln Leu Val Pro Val Arg Ala Leu Gly Leu Gly His 
            20                  25                  30          


Arg Ser Asp Glu Leu Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg 
        35                  40                  45              


Glu Ala Glu Ser Pro His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala 
    50                  55                  60                  


Gly Ala Leu Arg Pro Pro Pro Gly Ser Arg Pro Val Ser Gln Pro Cys 
65                  70                  75                  80  


Cys Arg Pro Thr Arg Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser 
                85                  90                  95      


Thr Trp Arg Thr Val Asp Arg Leu Ser Ala Thr Ala Cys Gly Cys Leu 
            100                 105                 110         


Gly 
    


<210>  40
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  40

Ala Gly Gly Pro Gly Ser Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys 
1               5                   10                  15      


Arg Leu Arg Ser Gln Leu Val Pro Val Arg Ala Leu Gly Leu Gly His 
            20                  25                  30          


Arg Ser Asp Glu Leu Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Glu 
        35                  40                  45              


Arg Ala Glu Ser Pro His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala 
    50                  55                  60                  


Gly Ala Leu Arg Pro Pro Pro Gly Ser Arg Pro Val Ser Gln Pro Cys 
65                  70                  75                  80  


Cys Arg Pro Thr Arg Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser 
                85                  90                  95      


Thr Trp Arg Thr Val Asp Arg Leu Ser Ala Thr Ala Cys Gly Cys Leu 
            100                 105                 110         


Gly 
    


