                         SEQUENCE LISTING

<110>  BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
 
<120>  STABILIZED HUMAN IMMUNODEFICIENCY VIRUS (HIV) ENVELOPE (ENV) 
       TRIMER VACCINES AND METHODS OF USING SAME

<130>  01948-223WO2

<150>  61/749,737
<151>  2013-01-07

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  712
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (mEnv)

<400>  1

Met Arg Val Thr Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Ile Leu Met Ile Cys Ser Ala Ala Gly Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Asp Val Arg Asn Val Thr Asn Asn Ala Thr Asn Thr 
    130                 135                 140                 


Asn Ser Ser Trp Gly Glu Pro Met Glu Lys Gly Glu Ile Lys Asn Cys 
145                 150                 155                 160 


Ser Phe Asn Ile Thr Thr Ser Ile Arg Asn Lys Val Gln Lys Gln Tyr 
                165                 170                 175     


Ala Leu Phe Tyr Lys Leu Asp Val Val Pro Ile Asp Asn Asp Ser Asn 
            180                 185                 190         


Asn Thr Asn Tyr Arg Leu Ile Ser Cys Asn Thr Ser Val Ile Thr Gln 
        195                 200                 205             


Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala 
    210                 215                 220                 


Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn Gly 
225                 230                 235                 240 


Thr Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
                245                 250                 255     


Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
            260                 265                 270         


Glu Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys Thr 
        275                 280                 285             


Ile Met Val Gln Leu Asn Val Ser Val Glu Ile Asn Cys Thr Arg Pro 
    290                 295                 300                 


Asn Asn Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly Arg Ala Phe 
305                 310                 315                 320 


Tyr Thr Ala Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn 
                325                 330                 335     


Ile Ser Arg Ala Asn Trp Asn Asn Thr Leu Arg Gln Ile Val Glu Lys 
            340                 345                 350         


Leu Gly Lys Gln Phe Gly Asn Asn Lys Thr Ile Val Phe Asn His Ser 
        355                 360                 365             


Ser Gly Gly Asp Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly 
    370                 375                 380                 


Glu Phe Phe Tyr Cys Asn Ser Thr Lys Leu Phe Asn Ser Thr Trp Thr 
385                 390                 395                 400 


Trp Asn Asn Ser Thr Trp Asn Asn Thr Lys Arg Ser Asn Asp Thr Glu 
                405                 410                 415     


Glu His Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp 
            420                 425                 430         


Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile 
        435                 440                 445             


Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly 
    450                 455                 460                 


Asn Asp Thr Ser Gly Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met 
465                 470                 475                 480 


Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile 
                485                 490                 495     


Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln 
            500                 505                 510         


Ser Glu Lys Ser Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu 
        515                 520                 525             


Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val 
    530                 535                 540                 


Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu 
545                 550                 555                 560 


Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp 
                565                 570                 575     


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu 
            580                 585                 590         


Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile 
        595                 600                 605             


Cys Thr Thr Thr Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu 
    610                 615                 620                 


Asp Lys Ile Trp Asn Asn Met Thr Trp Met Glu Trp Glu Arg Glu Ile 
625                 630                 635                 640 


Asn Asn Tyr Thr Ser Leu Ile Tyr Thr Leu Ile Glu Glu Ser Gln Asn 
                645                 650                 655     


Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala 
            660                 665                 670         


Ser Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp Gly Tyr Ile 
        675                 680                 685             


Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu 
    690                 695                 700                 


Trp Val Leu Leu Ser Thr Phe Leu 
705                 710         


<210>  2
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (mEnv+)

<400>  2

Met Arg Val Arg Gly Ile Gln Arg Asn Cys Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Met Leu Met Ile Cys Ser Ala Ala Gly Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Asp Val Arg Asn Val Thr Asn Asn Ala Thr Asn Thr 
    130                 135                 140                 


Asn Ser Ser Trp Gly Glu Pro Met Glu Lys Gly Glu Ile Lys Asn Cys 
145                 150                 155                 160 


Ser Phe Asn Ile Thr Thr Ser Ile Arg Asn Lys Val Gln Lys Gln Tyr 
                165                 170                 175     


Ala Leu Phe Tyr Lys Leu Asp Val Val Pro Ile Asp Asn Asp Ser Asn 
            180                 185                 190         


Asn Thr Asn Tyr Arg Leu Ile Ser Cys Asn Thr Ser Val Ile Thr Gln 
        195                 200                 205             


Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala 
    210                 215                 220                 


Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn Gly 
225                 230                 235                 240 


Thr Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
                245                 250                 255     


Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
            260                 265                 270         


Glu Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys Thr 
        275                 280                 285             


Ile Met Val Gln Leu Asn Val Ser Val Glu Ile Asn Cys Thr Arg Pro 
    290                 295                 300                 


Asn Asn Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly Arg Ala Phe 
305                 310                 315                 320 


Tyr Thr Ala Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn 
                325                 330                 335     


Ile Ser Arg Ala Asn Trp Asn Asn Thr Leu Arg Gln Ile Val Glu Lys 
            340                 345                 350         


Leu Gly Lys Gln Phe Gly Asn Asn Lys Thr Ile Val Phe Asn His Ser 
        355                 360                 365             


Ser Gly Gly Asp Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly 
    370                 375                 380                 


Glu Phe Phe Tyr Cys Asn Ser Thr Lys Leu Phe Asn Ser Thr Trp Thr 
385                 390                 395                 400 


Trp Asn Asn Ser Thr Trp Asn Asn Thr Lys Arg Ser Asn Asp Thr Glu 
                405                 410                 415     


Glu His Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp 
            420                 425                 430         


Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile 
        435                 440                 445             


Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly 
    450                 455                 460                 


Asn Asp Thr Ser Gly Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met 
465                 470                 475                 480 


Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile 
                485                 490                 495     


Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Glu Arg Val Val Gln 
            500                 505                 510         


Arg Glu Glu Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu 
        515                 520                 525             


Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val 
    530                 535                 540                 


Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu 
545                 550                 555                 560 


Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp 
                565                 570                 575     


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu 
            580                 585                 590         


Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile 
        595                 600                 605             


Cys Thr Thr Thr Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu 
    610                 615                 620                 


Asp Lys Ile Trp Asn Asn Met Thr Trp Met Glu Trp Glu Arg Glu Ile 
625                 630                 635                 640 


Asn Asn Tyr Thr Ser Leu Ile Tyr Thr Leu Ile Glu Glu Ser Gln Asn 
                645                 650                 655     


Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala 
            660                 665                 670         


Ser Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Lys 
        675                 680                 685             


Ser Arg Ile Glu Gly Arg Gly Ser Gly Gly Tyr Ile Pro Glu Ala Pro 
    690                 695                 700                 


Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu 
705                 710                 715                 720 


Ser Thr Phe Leu 
                


<210>  3
<211>  708
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (cEnv)

<400>  3

Met Arg Val Arg Gly Ile Gln Arg Asn Cys Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Leu Ile Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Asn 
            20                  25                  30          


Leu Trp Val Gly Asn Met Trp Val Thr Val Tyr Tyr Gly Val Pro Val 
        35                  40                  45              


Trp Thr Asp Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Thr Lys Ala 
    50                  55                  60                  


Tyr Asp Arg Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro 
65                  70                  75                  80  


Thr Asp Pro Asn Pro Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn 
                85                  90                  95      


Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln Met His Glu Asp Ile 
            100                 105                 110         


Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro 
        115                 120                 125             


Leu Cys Val Thr Leu His Cys Thr Asn Ala Thr Phe Lys Asn Asn Val 
    130                 135                 140                 


Thr Asn Asp Met Asn Lys Glu Ile Arg Asn Cys Ser Phe Asn Thr Thr 
145                 150                 155                 160 


Thr Glu Ile Arg Asp Lys Lys Gln Gln Gly Tyr Ala Leu Phe Tyr Arg 
                165                 170                 175     


Pro Asp Ile Val Leu Leu Lys Glu Asn Arg Asn Asn Ser Asn Asn Ser 
            180                 185                 190         


Glu Tyr Ile Leu Ile Asn Cys Asn Ala Ser Thr Ile Thr Gln Ala Cys 
        195                 200                 205             


Pro Lys Val Asn Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala 
    210                 215                 220                 


Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Ser Gly Lys Gly 
225                 230                 235                 240 


Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro 
                245                 250                 255     


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Lys Glu 
            260                 265                 270         


Ile Ile Ile Arg Ser Glu Asn Leu Thr Asp Asn Val Lys Thr Ile Ile 
        275                 280                 285             


Val His Leu Asn Lys Ser Val Glu Ile Val Cys Thr Arg Pro Asn Asn 
    290                 295                 300                 


Asn Thr Arg Lys Ser Met Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala 
305                 310                 315                 320 


Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala Tyr Cys Asn Ile Ser 
                325                 330                 335     


Gly Ser Lys Trp Asn Glu Thr Leu Lys Arg Val Lys Glu Lys Leu Gln 
            340                 345                 350         


Glu Asn Tyr Asn Asn Asn Lys Thr Ile Lys Phe Ala Pro Ser Ser Gly 
        355                 360                 365             


Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe 
    370                 375                 380                 


Phe Tyr Cys Asn Thr Thr Arg Leu Phe Asn Asn Asn Ala Thr Glu Asp 
385                 390                 395                 400 


Glu Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp 
                405                 410                 415     


Gln Gly Val Gly Arg Ala Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile 
            420                 425                 430         


Thr Cys Lys Ser Asn Ile Thr Gly Leu Leu Leu Val Arg Asp Gly Gly 
        435                 440                 445             


Glu Asp Asn Lys Thr Glu Glu Ile Phe Arg Pro Gly Gly Gly Asn Met 
    450                 455                 460                 


Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Ile Glu Leu 
465                 470                 475                 480 


Lys Pro Leu Gly Ile Ala Pro Thr Gly Ala Lys Glu Arg Val Val Glu 
                485                 490                 495     


Arg Glu Glu Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu 
            500                 505                 510         


Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Leu Thr Leu Thr Val 
        515                 520                 525             


Gln Ala Arg Gln Leu Leu Ser Ser Ile Val Gln Gln Gln Ser Asn Leu 
    530                 535                 540                 


Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp 
545                 550                 555                 560 


Gly Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu 
                565                 570                 575     


Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile 
            580                 585                 590         


Cys Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln 
        595                 600                 605             


Thr Asp Ile Trp Asn Asn Met Thr Trp Met Glu Trp Asp Arg Glu Ile 
    610                 615                 620                 


Ser Asn Tyr Thr Asp Thr Ile Tyr Arg Leu Leu Glu Asp Ser Gln Thr 
625                 630                 635                 640 


Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys 
                645                 650                 655     


Asn Leu Trp Ser Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Lys 
            660                 665                 670         


Ser Arg Ile Glu Gly Arg Gly Ser Gly Gly Tyr Ile Pro Glu Ala Pro 
        675                 680                 685             


Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu 
    690                 695                 700                 


Ser Thr Phe Leu 
705             


<210>  4
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (mEnv2)

<400>  4

Met Arg Val Arg Gly Ile Gln Arg Asn Trp Pro Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Ile Ile Ile Cys Arg Val Met Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Met Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Arg Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Glu Cys Arg Asn Val Arg Asn Val Ser Ser Asn Gly Thr Tyr Asn Ile 
    130                 135                 140                 


Ile His Asn Glu Thr Tyr Lys Glu Met Lys Asn Cys Ser Phe Asn Ala 
145                 150                 155                 160 


Thr Thr Val Val Glu Asp Arg Lys Gln Lys Val His Ala Leu Phe Tyr 
                165                 170                 175     


Arg Leu Asp Ile Val Pro Leu Asp Glu Asn Asn Ser Ser Glu Lys Ser 
            180                 185                 190         


Ser Glu Asn Ser Ser Glu Tyr Tyr Arg Leu Ile Asn Cys Asn Thr Ser 
        195                 200                 205             


Ala Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile 
    210                 215                 220                 


His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys 
225                 230                 235                 240 


Thr Phe Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys 
                245                 250                 255     


Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly 
            260                 265                 270         


Ser Leu Ala Glu Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn 
        275                 280                 285             


Asn Ala Lys Thr Ile Ile Val His Leu Asn Glu Thr Val Asn Ile Thr 
    290                 295                 300                 


Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro 
305                 310                 315                 320 


Gly Gln Thr Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln 
                325                 330                 335     


Ala His Cys Asn Leu Ser Arg Asp Gly Trp Asn Lys Thr Leu Gln Gly 
            340                 345                 350         


Val Lys Lys Lys Leu Ala Glu His Phe Pro Asn Lys Thr Ile Asn Phe 
        355                 360                 365             


Thr Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn 
    370                 375                 380                 


Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Gly 
385                 390                 395                 400 


Thr Tyr Met Pro Asn Gly Thr Asn Ser Asn Ser Ser Ser Asn Ile Thr 
                405                 410                 415     


Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly 
            420                 425                 430         


Arg Ala Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Arg Ser 
        435                 440                 445             


Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Ser Asn Asn Gly 
    450                 455                 460                 


Val Pro Asn Asp Thr Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg 
465                 470                 475                 480 


Asn Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Val Lys 
                485                 490                 495     


Pro Leu Gly Val Ala Pro Thr Glu Ala Lys Arg Arg Val Val Glu Ser 
            500                 505                 510         


Glu Lys Ser Ala Val Gly Ile Gly Ala Val Phe Leu Gly Ile Leu Gly 
        515                 520                 525             


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln 
    530                 535                 540                 


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
545                 550                 555                 560 


Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly 
                565                 570                 575     


Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Gln 
            580                 585                 590         


Asp Gln Gln Leu Leu Gly Leu Trp Gly Cys Ser Gly Lys Leu Ile Cys 
        595                 600                 605             


Thr Thr Ala Val Pro Trp Asn Thr Ser Trp Ser Asn Lys Ser Gln Thr 
    610                 615                 620                 


Asp Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Lys Glu Ile Gly 
625                 630                 635                 640 


Asn Tyr Thr Gly Glu Ile Tyr Arg Leu Leu Glu Glu Ser Gln Asn Gln 
                645                 650                 655     


Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn 
            660                 665                 670         


Leu Trp Asn Trp Phe Asp Ile Thr Asn Trp Leu Trp 
        675                 680                 


<210>  5
<211>  678
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (mEnv3)

<400>  5

Met Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Lys Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Gln 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Arg Glu Val 
    50                  55                  60                  


His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Val Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Glu Ser Leu Lys Pro Cys Val Lys Leu Ala Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asn Ala Asn Leu Asn Cys Thr Asn Asp Asn Cys Asn Arg 
    130                 135                 140                 


Thr Val Asp Lys Met Arg Glu Glu Ile Lys Asn Cys Ser Phe Asn Met 
145                 150                 155                 160 


Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys Val Tyr Ala Leu Phe Tyr 
                165                 170                 175     


Lys Leu Asp Ile Val Pro Ile Glu Lys Asn Ser Ser Glu Tyr Arg Leu 
            180                 185                 190         


Ile Asn Cys Asn Thr Ser Thr Ile Thr Gln Ala Cys Pro Lys Val Thr 
        195                 200                 205             


Phe Glu Pro Ile Pro Ile His Tyr Cys Thr Pro Ala Gly Phe Ala Ile 
    210                 215                 220                 


Leu Lys Cys Lys Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Lys Asn 
225                 230                 235                 240 


Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro Val Ile Ser Thr 
                245                 250                 255     


Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Gly Glu Ile Ile Ile Arg 
            260                 265                 270         


Ser Glu Asn Ile Thr Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Asn 
        275                 280                 285             


Glu Ser Val Val Ile Asn Cys Thr Arg Pro Gly Asn Asn Thr Arg Lys 
    290                 295                 300                 


Ser Val Arg Ile Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Glu Ile 
305                 310                 315                 320 


Ile Gly Asp Ile Arg Gln Ala Tyr Cys Asn Ile Ser Arg Ala Lys Trp 
                325                 330                 335     


Asn Asn Thr Leu Lys Gln Ile Val Thr Lys Leu Lys Glu Gln Phe Lys 
            340                 345                 350         


Asn Lys Thr Ile Val Phe Asn Gln Ser Ser Gly Gly Asp Pro Glu Ile 
        355                 360                 365             


Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr 
    370                 375                 380                 


Thr Gln Leu Phe Asn Ser Thr Trp Asn Ser Asn Ser Thr Trp Asn Asp 
385                 390                 395                 400 


Thr Thr Gly Ser Val Thr Glu Gly Asn Asp Thr Ile Thr Leu Pro Cys 
                405                 410                 415     


Arg Ile Lys Gln Ile Val Asn Met Trp Gln Arg Val Gly Gln Ala Met 
            420                 425                 430         


Tyr Ala Pro Pro Ile Glu Gly Asn Ile Thr Cys Lys Ser Asn Ile Thr 
        435                 440                 445             


Gly Leu Leu Leu Val Arg Asp Gly Gly Asn Ile Asn Arg Thr Asn Glu 
    450                 455                 460                 


Thr Phe Arg Pro Gly Gly Gly Asn Met Lys Asp Asn Trp Arg Ser Glu 
465                 470                 475                 480 


Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Val Ala Pro 
                485                 490                 495     


Thr Arg Ala Lys Arg Arg Val Val Glu Ser Glu Lys Ser Ala Val Gly 
            500                 505                 510         


Leu Gly Ala Val Phe Leu Gly Phe Leu Gly Thr Ala Gly Ser Thr Met 
        515                 520                 525             


Gly Ala Ala Ser Leu Thr Leu Thr Val Gln Ala Arg Gln Val Leu Ser 
    530                 535                 540                 


Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Lys Ala Ile Glu Ala Gln 
545                 550                 555                 560 


Gln His Leu Leu Lys Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala 
                565                 570                 575     


Arg Ile Leu Ala Val Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly 
            580                 585                 590         


Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Asn Val Pro Trp 
        595                 600                 605             


Asn Ser Ser Trp Ser Asn Lys Ser Gln Glu Glu Ile Trp Asn Asn Met 
    610                 615                 620                 


Thr Trp Met Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr Asp Thr Ile 
625                 630                 635                 640 


Tyr Arg Leu Leu Glu Asp Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln 
                645                 650                 655     


Asp Leu Leu Ala Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Ser 
            660                 665                 670         


Ile Thr Asn Trp Leu Trp 
        675             


<210>  6
<211>  685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mosaic gp140 Env1)

<400>  6

Met Arg Val Thr Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Ile Leu Met Ile Cys Ser Ala Ala Gly Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Asp Val Arg Asn Val Thr Asn Asn Ala Thr Asn Thr 
    130                 135                 140                 


Asn Ser Ser Trp Gly Glu Pro Met Glu Lys Gly Glu Ile Lys Asn Cys 
145                 150                 155                 160 


Ser Phe Asn Ile Thr Thr Ser Ile Arg Asn Lys Val Gln Lys Gln Tyr 
                165                 170                 175     


Ala Leu Phe Tyr Lys Leu Asp Val Val Pro Ile Asp Asn Asp Ser Asn 
            180                 185                 190         


Asn Thr Asn Tyr Arg Leu Ile Ser Cys Asn Thr Ser Val Ile Thr Gln 
        195                 200                 205             


Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala 
    210                 215                 220                 


Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn Gly 
225                 230                 235                 240 


Thr Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
                245                 250                 255     


Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
            260                 265                 270         


Glu Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys Thr 
        275                 280                 285             


Ile Met Val Gln Leu Asn Val Ser Val Glu Ile Asn Cys Thr Arg Pro 
    290                 295                 300                 


Asn Asn Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly Arg Ala Phe 
305                 310                 315                 320 


Tyr Thr Ala Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn 
                325                 330                 335     


Ile Ser Arg Ala Asn Trp Asn Asn Thr Leu Arg Gln Ile Val Glu Lys 
            340                 345                 350         


Leu Gly Lys Gln Phe Gly Asn Asn Lys Thr Ile Val Phe Asn His Ser 
        355                 360                 365             


Ser Gly Gly Asp Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly 
    370                 375                 380                 


Glu Phe Phe Tyr Cys Asn Ser Thr Lys Leu Phe Asn Ser Thr Trp Thr 
385                 390                 395                 400 


Trp Asn Asn Ser Thr Trp Asn Asn Thr Lys Arg Ser Asn Asp Thr Glu 
                405                 410                 415     


Glu His Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp 
            420                 425                 430         


Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile 
        435                 440                 445             


Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly 
    450                 455                 460                 


Asn Asp Thr Ser Gly Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met 
465                 470                 475                 480 


Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile 
                485                 490                 495     


Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln 
            500                 505                 510         


Ser Glu Lys Ser Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu 
        515                 520                 525             


Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val 
    530                 535                 540                 


Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu 
545                 550                 555                 560 


Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp 
                565                 570                 575     


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu 
            580                 585                 590         


Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile 
        595                 600                 605             


Cys Thr Thr Thr Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu 
    610                 615                 620                 


Asp Lys Ile Trp Asn Asn Met Thr Trp Met Glu Trp Glu Arg Glu Ile 
625                 630                 635                 640 


Asn Asn Tyr Thr Ser Leu Ile Tyr Thr Leu Ile Glu Glu Ser Gln Asn 
                645                 650                 655     


Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala 
            660                 665                 670         


Ser Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp 
        675                 680                 685 


<210>  7
<211>  1350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mosaic gagpol1 v3)

<400>  7

Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Arg Leu Lys 
            20                  25                  30          


His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 
    50                  55                  60                  


Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 
65                  70                  75                  80  


Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Glu Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 
            100                 105                 110         


Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly Asn Ser Ser Gln Val 
        115                 120                 125             


Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 
    130                 135                 140                 


Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 
145                 150                 155                 160 


Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 
                165                 170                 175     


Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 
            180                 185                 190         


Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 
        195                 200                 205             


Ala Ala Glu Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala 
    210                 215                 220                 


Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 
225                 230                 235                 240 


Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 
                245                 250                 255     


Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 
            260                 265                 270         


Ile Val Arg Met Tyr Ser Pro Val Ser Ile Leu Asp Ile Arg Gln Gly 
        275                 280                 285             


Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 
    290                 295                 300                 


Arg Ala Glu Gln Ala Ser Gln Asp Val Lys Asn Trp Met Thr Glu Thr 
305                 310                 315                 320 


Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 
                325                 330                 335     


Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 
            340                 345                 350         


Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met Ser 
        355                 360                 365             


Gln Val Thr Asn Ser Ala Thr Ile Met Met Gln Arg Gly Asn Phe Arg 
    370                 375                 380                 


Asn Gln Arg Lys Thr Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His 
385                 390                 395                 400 


Ile Ala Lys Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys 
                405                 410                 415     


Gly Lys Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn 
            420                 425                 430         


Phe Leu Gly Lys Ile Trp Pro Ser Asn Lys Gly Arg Pro Gly Asn Phe 
        435                 440                 445             


Leu Gln Asn Arg Pro Glu Pro Thr Ala Pro Pro Glu Glu Ser Phe Arg 
    450                 455                 460                 


Phe Gly Glu Glu Thr Thr Thr Pro Ser Gln Lys Gln Glu Pro Ile Asp 
465                 470                 475                 480 


Lys Glu Met Tyr Pro Leu Ala Ser Leu Lys Ser Leu Phe Gly Asn Asp 
                485                 490                 495     


Pro Ser Ser Gln Met Ala Pro Ile Ser Pro Ile Glu Thr Val Pro Val 
            500                 505                 510         


Lys Leu Lys Pro Gly Met Asp Gly Pro Arg Val Lys Gln Trp Pro Leu 
        515                 520                 525             


Thr Glu Glu Lys Ile Lys Ala Leu Thr Ala Ile Cys Glu Glu Met Glu 
    530                 535                 540                 


Lys Glu Gly Lys Ile Thr Lys Ile Gly Pro Glu Asn Pro Tyr Asn Thr 
545                 550                 555                 560 


Pro Val Phe Ala Ile Lys Lys Lys Asp Ser Thr Lys Trp Arg Lys Leu 
                565                 570                 575     


Val Asp Phe Arg Glu Leu Asn Lys Arg Thr Gln Asp Phe Trp Glu Val 
            580                 585                 590         


Gln Leu Gly Ile Pro His Pro Ala Gly Leu Lys Lys Lys Lys Ser Val 
        595                 600                 605             


Thr Val Leu Ala Val Gly Asp Ala Tyr Phe Ser Val Pro Leu Asp Glu 
    610                 615                 620                 


Gly Phe Arg Lys Tyr Thr Ala Phe Thr Ile Pro Ser Thr Asn Asn Glu 
625                 630                 635                 640 


Thr Pro Gly Ile Arg Tyr Gln Tyr Asn Val Leu Pro Gln Gly Trp Lys 
                645                 650                 655     


Gly Ser Pro Ala Ile Phe Gln Cys Ser Met Thr Arg Ile Leu Glu Pro 
            660                 665                 670         


Phe Arg Ala Lys Asn Pro Glu Ile Val Ile Tyr Gln Tyr Met Ala Ala 
        675                 680                 685             


Leu Tyr Val Gly Ser Asp Leu Glu Ile Gly Gln His Arg Ala Lys Ile 
    690                 695                 700                 


Glu Glu Leu Arg Glu His Leu Leu Lys Trp Gly Phe Thr Thr Pro Asp 
705                 710                 715                 720 


Lys Lys His Gln Lys Glu Pro Pro Phe Leu Trp Met Gly Tyr Glu Leu 
                725                 730                 735     


His Pro Asp Lys Trp Thr Val Gln Pro Ile Gln Leu Pro Glu Lys Asp 
            740                 745                 750         


Ser Trp Thr Val Asn Asp Ile Gln Lys Leu Val Gly Lys Leu Asn Trp 
        755                 760                 765             


Ala Ser Gln Ile Tyr Pro Gly Ile Lys Val Arg Gln Leu Cys Lys Leu 
    770                 775                 780                 


Leu Arg Gly Ala Lys Ala Leu Thr Asp Ile Val Pro Leu Thr Glu Glu 
785                 790                 795                 800 


Ala Glu Leu Glu Leu Ala Glu Asn Arg Glu Ile Leu Lys Glu Pro Val 
                805                 810                 815     


His Gly Val Tyr Tyr Asp Pro Ser Lys Asp Leu Ile Ala Glu Ile Gln 
            820                 825                 830         


Lys Gln Gly His Asp Gln Trp Thr Tyr Gln Ile Tyr Gln Glu Pro Phe 
        835                 840                 845             


Lys Asn Leu Lys Thr Gly Lys Tyr Ala Lys Met Arg Thr Ala His Thr 
    850                 855                 860                 


Asn Asp Val Lys Gln Leu Thr Glu Ala Val Gln Lys Ile Ala Met Glu 
865                 870                 875                 880 


Ser Ile Val Ile Trp Gly Lys Thr Pro Lys Phe Arg Leu Pro Ile Gln 
                885                 890                 895     


Lys Glu Thr Trp Glu Thr Trp Trp Thr Asp Tyr Trp Gln Ala Thr Trp 
            900                 905                 910         


Ile Pro Glu Trp Glu Phe Val Asn Thr Pro Pro Leu Val Lys Leu Trp 
        915                 920                 925             


Tyr Gln Leu Glu Lys Asp Pro Ile Ala Gly Val Glu Thr Phe Tyr Val 
    930                 935                 940                 


Ala Gly Ala Ala Asn Arg Glu Thr Lys Leu Gly Lys Ala Gly Tyr Val 
945                 950                 955                 960 


Thr Asp Arg Gly Arg Gln Lys Ile Val Ser Leu Thr Glu Thr Thr Asn 
                965                 970                 975     


Gln Lys Thr Ala Leu Gln Ala Ile Tyr Leu Ala Leu Gln Asp Ser Gly 
            980                 985                 990         


Ser Glu Val Asn Ile Val Thr Ala  Ser Gln Tyr Ala Leu  Gly Ile Ile 
        995                 1000                 1005             


Gln Ala  Gln Pro Asp Lys Ser  Glu Ser Glu Leu Val  Asn Gln Ile 
    1010                 1015                 1020             


Ile Glu  Gln Leu Ile Lys Lys  Glu Arg Val Tyr Leu  Ser Trp Val 
    1025                 1030                 1035             


Pro Ala  His Lys Gly Ile Gly  Gly Asn Glu Gln Val  Asp Lys Leu 
    1040                 1045                 1050             


Val Ser  Ser Gly Ile Arg Lys  Val Leu Phe Leu Asp  Gly Ile Asp 
    1055                 1060                 1065             


Lys Ala  Gln Glu Glu His Glu  Lys Tyr His Ser Asn  Trp Arg Ala 
    1070                 1075                 1080             


Met Ala  Ser Asp Phe Asn Leu  Pro Pro Val Val Ala  Lys Glu Ile 
    1085                 1090                 1095             


Val Ala  Ser Cys Asp Gln Cys  Gln Leu Lys Gly Glu  Ala Met His 
    1100                 1105                 1110             


Gly Gln  Val Asp Cys Ser Pro  Gly Ile Trp Gln Leu  Ala Cys Thr 
    1115                 1120                 1125             


His Leu  Glu Gly Lys Ile Ile  Leu Val Ala Val His  Val Ala Ser 
    1130                 1135                 1140             


Gly Tyr  Ile Glu Ala Glu Val  Ile Pro Ala Glu Thr  Gly Gln Glu 
    1145                 1150                 1155             


Thr Ala  Tyr Phe Ile Leu Lys  Leu Ala Gly Arg Trp  Pro Val Lys 
    1160                 1165                 1170             


Val Ile  His Thr Ala Asn Gly  Ser Asn Phe Thr Ser  Ala Ala Val 
    1175                 1180                 1185             


Lys Ala  Ala Cys Trp Trp Ala  Gly Ile Gln Gln Glu  Phe Gly Ile 
    1190                 1195                 1200             


Pro Tyr  Asn Pro Gln Ser Gln  Gly Val Val Ala Ser  Met Asn Lys 
    1205                 1210                 1215             


Glu Leu  Lys Lys Ile Ile Gly  Gln Val Arg Asp Gln  Ala Glu His 
    1220                 1225                 1230             


Leu Lys  Thr Ala Val Gln Met  Ala Val Phe Ile His  Asn Phe Lys 
    1235                 1240                 1245             


Arg Lys  Gly Gly Ile Gly Gly  Tyr Ser Ala Gly Glu  Arg Ile Ile 
    1250                 1255                 1260             


Asp Ile  Ile Ala Thr Asp Ile  Gln Thr Lys Glu Leu  Gln Lys Gln 
    1265                 1270                 1275             


Ile Ile  Lys Ile Gln Asn Phe  Arg Val Tyr Tyr Arg  Asp Ser Arg 
    1280                 1285                 1290             


Asp Pro  Ile Trp Lys Gly Pro  Ala Lys Leu Leu Trp  Lys Gly Glu 
    1295                 1300                 1305             


Gly Ala  Val Val Ile Gln Asp  Asn Ser Asp Ile Lys  Val Val Pro 
    1310                 1315                 1320             


Arg Arg  Lys Val Lys Ile Ile  Lys Asp Tyr Gly Lys  Gln Met Ala 
    1325                 1330                 1335             


Gly Ala  Asp Cys Val Ala Gly  Arg Gln Asp Glu Asp  
    1340                 1345                 1350 


<210>  8
<211>  857
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mosaic gp160 Env1)

<400>  8

Met Arg Val Thr Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Ile Leu Met Ile Cys Ser Ala Ala Gly Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Asp Val Arg Asn Val Thr Asn Asn Ala Thr Asn Thr 
    130                 135                 140                 


Asn Ser Ser Trp Gly Glu Pro Met Glu Lys Gly Glu Ile Lys Asn Cys 
145                 150                 155                 160 


Ser Phe Asn Ile Thr Thr Ser Ile Arg Asn Lys Val Gln Lys Gln Tyr 
                165                 170                 175     


Ala Leu Phe Tyr Lys Leu Asp Val Val Pro Ile Asp Asn Asp Ser Asn 
            180                 185                 190         


Asn Thr Asn Tyr Arg Leu Ile Ser Cys Asn Thr Ser Val Ile Thr Gln 
        195                 200                 205             


Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala 
    210                 215                 220                 


Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn Gly 
225                 230                 235                 240 


Thr Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
                245                 250                 255     


Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
            260                 265                 270         


Glu Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys Thr 
        275                 280                 285             


Ile Met Val Gln Leu Asn Val Ser Val Glu Ile Asn Cys Thr Arg Pro 
    290                 295                 300                 


Asn Asn Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly Arg Ala Phe 
305                 310                 315                 320 


Tyr Thr Ala Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn 
                325                 330                 335     


Ile Ser Arg Ala Asn Trp Asn Asn Thr Leu Arg Gln Ile Val Glu Lys 
            340                 345                 350         


Leu Gly Lys Gln Phe Gly Asn Asn Lys Thr Ile Val Phe Asn His Ser 
        355                 360                 365             


Ser Gly Gly Asp Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly 
    370                 375                 380                 


Glu Phe Phe Tyr Cys Asn Ser Thr Lys Leu Phe Asn Ser Thr Trp Thr 
385                 390                 395                 400 


Trp Asn Asn Ser Thr Trp Asn Asn Thr Lys Arg Ser Asn Asp Thr Glu 
                405                 410                 415     


Glu His Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp 
            420                 425                 430         


Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile 
        435                 440                 445             


Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly 
    450                 455                 460                 


Asn Asp Thr Ser Gly Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met 
465                 470                 475                 480 


Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile 
                485                 490                 495     


Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln 
            500                 505                 510         


Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu 
        515                 520                 525             


Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val 
    530                 535                 540                 


Gln Ala Arg Leu Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu 
545                 550                 555                 560 


Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp 
                565                 570                 575     


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu 
            580                 585                 590         


Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile 
        595                 600                 605             


Cys Thr Thr Thr Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu 
    610                 615                 620                 


Asp Lys Ile Trp Asn Asn Met Thr Trp Met Glu Trp Glu Arg Glu Ile 
625                 630                 635                 640 


Asn Asn Tyr Thr Ser Leu Ile Tyr Thr Leu Ile Glu Glu Ser Gln Asn 
                645                 650                 655     


Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala 
            660                 665                 670         


Ser Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Lys 
        675                 680                 685             


Ile Phe Ile Met Ile Val Gly Gly Leu Val Gly Leu Arg Ile Val Phe 
    690                 695                 700                 


Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu 
705                 710                 715                 720 


Ser Phe Gln Thr Arg Leu Pro Ala Pro Arg Gly Pro Asp Arg Pro Glu 
                725                 730                 735     


Gly Ile Glu Glu Glu Gly Gly Glu Arg Asp Arg Asp Arg Ser Val Arg 
            740                 745                 750         


Leu Val Asp Gly Phe Leu Val Leu Ile Trp Asp Asp Leu Gln Ser Leu 
        755                 760                 765             


Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Leu Leu Ile Val Glu 
    770                 775                 780                 


Leu Leu Gly Arg Arg Gly Trp Glu Ala Leu Lys Tyr Trp Trp Asn Leu 
785                 790                 795                 800 


Leu Gln Tyr Trp Ser Gln Glu Leu Lys Asn Ser Ala Ile Ser Leu Leu 
                805                 810                 815     


Asn Ala Thr Ala Val Ala Val Ala Glu Gly Thr Asp Arg Val Ile Glu 
            820                 825                 830         


Ala Leu Gln Arg Ala Cys Arg Ala Ile Leu His Ile Pro Arg Arg Ile 
        835                 840                 845             


Arg Gln Gly Leu Glu Arg Leu Leu Leu 
    850                 855         


<210>  9
<211>  867
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mosaic gp160 Env2)

<400>  9

Met Arg Val Arg Gly Ile Gln Arg Asn Trp Pro Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Ile Ile Ile Cys Arg Val Met Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Met Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Arg Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Glu Cys Arg Asn Val Arg Asn Val Ser Ser Asn Gly Thr Tyr Asn Ile 
    130                 135                 140                 


Ile His Asn Glu Thr Tyr Lys Glu Met Lys Asn Cys Ser Phe Asn Ala 
145                 150                 155                 160 


Thr Thr Val Val Glu Asp Arg Lys Gln Lys Val His Ala Leu Phe Tyr 
                165                 170                 175     


Arg Leu Asp Ile Val Pro Leu Asp Glu Asn Asn Ser Ser Glu Lys Ser 
            180                 185                 190         


Ser Glu Asn Ser Ser Glu Tyr Tyr Arg Leu Ile Asn Cys Asn Thr Ser 
        195                 200                 205             


Ala Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile 
    210                 215                 220                 


His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys 
225                 230                 235                 240 


Thr Phe Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys 
                245                 250                 255     


Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly 
            260                 265                 270         


Ser Leu Ala Glu Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn 
        275                 280                 285             


Asn Ala Lys Thr Ile Ile Val His Leu Asn Glu Thr Val Asn Ile Thr 
    290                 295                 300                 


Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro 
305                 310                 315                 320 


Gly Gln Thr Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln 
                325                 330                 335     


Ala His Cys Asn Leu Ser Arg Asp Gly Trp Asn Lys Thr Leu Gln Gly 
            340                 345                 350         


Val Lys Lys Lys Leu Ala Glu His Phe Pro Asn Lys Thr Ile Asn Phe 
        355                 360                 365             


Thr Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn 
    370                 375                 380                 


Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Gly 
385                 390                 395                 400 


Thr Tyr Met Pro Asn Gly Thr Asn Ser Asn Ser Ser Ser Asn Ile Thr 
                405                 410                 415     


Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly 
            420                 425                 430         


Arg Ala Met Tyr Ala Pro Pro Ile Ala Gly Asn Ile Thr Cys Arg Ser 
        435                 440                 445             


Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Ser Asn Asn Gly 
    450                 455                 460                 


Val Pro Asn Asp Thr Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg 
465                 470                 475                 480 


Asn Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Val Lys 
                485                 490                 495     


Pro Leu Gly Val Ala Pro Thr Glu Ala Lys Arg Arg Val Val Glu Arg 
            500                 505                 510         


Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Ile Leu Gly 
        515                 520                 525             


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln 
    530                 535                 540                 


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
545                 550                 555                 560 


Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly 
                565                 570                 575     


Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Gln 
            580                 585                 590         


Asp Gln Gln Leu Leu Gly Leu Trp Gly Cys Ser Gly Lys Leu Ile Cys 
        595                 600                 605             


Thr Thr Ala Val Pro Trp Asn Thr Ser Trp Ser Asn Lys Ser Gln Thr 
    610                 615                 620                 


Asp Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Lys Glu Ile Gly 
625                 630                 635                 640 


Asn Tyr Thr Gly Glu Ile Tyr Arg Leu Leu Glu Glu Ser Gln Asn Gln 
                645                 650                 655     


Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn 
            660                 665                 670         


Leu Trp Asn Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile 
        675                 680                 685             


Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Leu Gly 
    690                 695                 700                 


Val Leu Ser Ile Val Arg Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser 
705                 710                 715                 720 


Phe Gln Thr Leu Thr Pro Asn Pro Arg Gly Leu Asp Arg Leu Gly Arg 
                725                 730                 735     


Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Asp Arg Ser Ile Arg Leu 
            740                 745                 750         


Val Asn Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys 
        755                 760                 765             


Leu Phe Ser Tyr His Gln Leu Arg Asp Phe Ile Leu Ile Val Ala Arg 
    770                 775                 780                 


Ala Val Glu Leu Leu Gly Arg Ser Ser Leu Arg Gly Leu Gln Arg Gly 
785                 790                 795                 800 


Trp Glu Ala Leu Lys Tyr Leu Gly Asn Leu Val Gln Tyr Trp Gly Leu 
                805                 810                 815     


Glu Leu Lys Lys Gly Ala Ile Ser Leu Leu Asp Thr Ile Ala Ile Ala 
            820                 825                 830         


Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Leu Ile Gln Ser Ile Cys 
        835                 840                 845             


Arg Ala Ile Arg Asn Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu Ala 
    850                 855                 860                 


Ser Leu Leu 
865         


<210>  10
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mosaic gag1)

<400>  10

Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Arg Leu Lys 
            20                  25                  30          


His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 
    50                  55                  60                  


Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 
65                  70                  75                  80  


Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Glu Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 
            100                 105                 110         


Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly Asn Ser Ser Gln Val 
        115                 120                 125             


Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 
    130                 135                 140                 


Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 
145                 150                 155                 160 


Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 
                165                 170                 175     


Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 
            180                 185                 190         


Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 
        195                 200                 205             


Ala Ala Glu Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala 
    210                 215                 220                 


Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 
225                 230                 235                 240 


Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 
                245                 250                 255     


Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 
            260                 265                 270         


Ile Val Arg Met Tyr Ser Pro Val Ser Ile Leu Asp Ile Arg Gln Gly 
        275                 280                 285             


Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 
    290                 295                 300                 


Arg Ala Glu Gln Ala Ser Gln Asp Val Lys Asn Trp Met Thr Glu Thr 
305                 310                 315                 320 


Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 
                325                 330                 335     


Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 
            340                 345                 350         


Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met Ser 
        355                 360                 365             


Gln Val Thr Asn Ser Ala Thr Ile Met Met Gln Arg Gly Asn Phe Arg 
    370                 375                 380                 


Asn Gln Arg Lys Thr Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His 
385                 390                 395                 400 


Ile Ala Lys Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys 
                405                 410                 415     


Gly Lys Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn 
            420                 425                 430         


Phe Leu Gly Lys Ile Trp Pro Ser Asn Lys Gly Arg Pro Gly Asn Phe 
        435                 440                 445             


Leu Gln Asn Arg Pro Glu Pro Thr Ala Pro Pro Glu Glu Ser Phe Arg 
    450                 455                 460                 


Phe Gly Glu Glu Thr Thr Thr Pro Ser Gln Lys Gln Glu Pro Ile Asp 
465                 470                 475                 480 


Lys Glu Met Tyr Pro Leu Ala Ser Leu Lys Ser Leu Phe Gly Asn Asp 
                485                 490                 495     


Pro Ser Ser Gln 
            500 


<210>  11
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mosaic gag2)

<400>  11

Met Gly Ala Arg Ala Ser Ile Leu Arg Gly Gly Lys Leu Asp Lys Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys His Tyr Met Leu Lys 
            20                  25                  30          


His Leu Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Leu Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Ser Glu Gly Cys Lys Gln Ile Ile Lys Gln Leu 
    50                  55                  60                  


Gln Pro Ala Leu Gln Thr Gly Thr Glu Glu Leu Arg Ser Leu Phe Asn 
65                  70                  75                  80  


Thr Val Ala Thr Leu Tyr Cys Val His Ala Glu Ile Glu Val Arg Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Gln 
            100                 105                 110         


Gln Lys Thr Gln Gln Ala Lys Glu Ala Asp Gly Lys Val Ser Gln Asn 
        115                 120                 125             


Tyr Pro Ile Val Gln Asn Leu Gln Gly Gln Met Val His Gln Pro Ile 
    130                 135                 140                 


Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Ile Glu Glu Lys Ala 
145                 150                 155                 160 


Phe Ser Pro Glu Val Ile Pro Met Phe Thr Ala Leu Ser Glu Gly Ala 
                165                 170                 175     


Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly Gly His Gln 
            180                 185                 190         


Ala Ala Met Gln Met Leu Lys Asp Thr Ile Asn Glu Glu Ala Ala Glu 
        195                 200                 205             


Trp Asp Arg Leu His Pro Val His Ala Gly Pro Val Ala Pro Gly Gln 
    210                 215                 220                 


Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr Ser Asn Leu 
225                 230                 235                 240 


Gln Glu Gln Ile Ala Trp Met Thr Ser Asn Pro Pro Ile Pro Val Gly 
                245                 250                 255     


Asp Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg 
            260                 265                 270         


Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Lys Gln Gly Pro Lys Glu 
        275                 280                 285             


Pro Phe Arg Asp Tyr Val Asp Arg Phe Phe Lys Thr Leu Arg Ala Glu 
    290                 295                 300                 


Gln Ala Thr Gln Asp Val Lys Asn Trp Met Thr Asp Thr Leu Leu Val 
305                 310                 315                 320 


Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Arg Ala Leu Gly Pro 
                325                 330                 335     


Gly Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly Val Gly Gly 
            340                 345                 350         


Pro Ser His Lys Ala Arg Val Leu Ala Glu Ala Met Ser Gln Thr Asn 
        355                 360                 365             


Ser Thr Ile Leu Met Gln Arg Ser Asn Phe Lys Gly Ser Lys Arg Ile 
    370                 375                 380                 


Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His Ile Ala Arg Asn Cys 
385                 390                 395                 400 


Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys Gly Lys Glu Gly His 
                405                 410                 415     


Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn Phe Leu Gly Lys Ile 
            420                 425                 430         


Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe Leu Gln Ser Arg Pro 
        435                 440                 445             


Glu Pro Thr Ala Pro Pro Ala Glu Ser Phe Arg Phe Glu Glu Thr Thr 
    450                 455                 460                 


Pro Ala Pro Lys Gln Glu Pro Lys Asp Arg Glu Pro Leu Thr Ser Leu 
465                 470                 475                 480 


Arg Ser Leu Phe Gly Ser Asp Pro Leu Ser Gln 
                485                 490     


<210>  12
<211>  999
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mosaic pol1)

<400>  12

Phe Phe Arg Glu Asn Leu Ala Phe Gln Gln Gly Glu Ala Arg Glu Phe 
1               5                   10                  15      


Pro Ser Glu Gln Thr Arg Ala Asn Ser Pro Thr Ser Arg Glu Leu Gln 
            20                  25                  30          


Val Arg Gly Asp Asn Pro His Ser Glu Ala Gly Ala Glu Arg Gln Gly 
        35                  40                  45              


Thr Leu Asn Phe Pro Gln Ile Thr Leu Trp Gln Arg Pro Leu Val Ser 
    50                  55                  60                  


Ile Lys Val Gly Gly Gln Ile Arg Glu Ala Leu Leu Asp Thr Gly Ala 
65                  70                  75                  80  


Asp Asp Thr Val Leu Glu Asp Ile Asn Leu Pro Gly Lys Trp Lys Pro 
                85                  90                  95      


Lys Met Ile Gly Gly Ile Gly Gly Phe Ile Lys Val Arg Gln Tyr Asp 
            100                 105                 110         


Gln Ile Leu Ile Glu Ile Cys Gly Lys Lys Ala Ile Gly Thr Val Leu 
        115                 120                 125             


Val Gly Pro Thr Pro Val Asn Ile Ile Gly Arg Asn Met Leu Thr Gln 
    130                 135                 140                 


Leu Gly Cys Thr Leu Asn Phe Pro Ile Ser Pro Ile Glu Thr Val Pro 
145                 150                 155                 160 


Val Lys Leu Lys Pro Gly Met Asp Gly Pro Arg Val Lys Gln Trp Pro 
                165                 170                 175     


Leu Thr Glu Glu Lys Ile Lys Ala Leu Thr Ala Ile Cys Glu Glu Met 
            180                 185                 190         


Glu Lys Glu Gly Lys Ile Thr Lys Ile Gly Pro Glu Asn Pro Tyr Asn 
        195                 200                 205             


Thr Pro Val Phe Ala Ile Lys Lys Lys Asp Ser Thr Lys Trp Arg Lys 
    210                 215                 220                 


Leu Val Asp Phe Arg Glu Leu Asn Lys Arg Thr Gln Asp Phe Trp Glu 
225                 230                 235                 240 


Val Gln Leu Gly Ile Pro His Pro Ala Gly Leu Lys Lys Lys Lys Ser 
                245                 250                 255     


Val Thr Val Leu Asp Val Gly Asp Ala Tyr Phe Ser Val Pro Leu Asp 
            260                 265                 270         


Glu Gly Phe Arg Lys Tyr Thr Ala Phe Thr Ile Pro Ser Thr Asn Asn 
        275                 280                 285             


Glu Thr Pro Gly Ile Arg Tyr Gln Tyr Asn Val Leu Pro Gln Gly Trp 
    290                 295                 300                 


Lys Gly Ser Pro Ala Ile Phe Gln Cys Ser Met Thr Arg Ile Leu Glu 
305                 310                 315                 320 


Pro Phe Arg Ala Lys Asn Pro Glu Ile Val Ile Tyr Gln Tyr Met Asp 
                325                 330                 335     


Asp Leu Tyr Val Gly Ser Asp Leu Glu Ile Gly Gln His Arg Ala Lys 
            340                 345                 350         


Ile Glu Glu Leu Arg Glu His Leu Leu Lys Trp Gly Phe Thr Thr Pro 
        355                 360                 365             


Asp Lys Lys His Gln Lys Glu Pro Pro Phe Leu Trp Met Gly Tyr Glu 
    370                 375                 380                 


Leu His Pro Asp Lys Trp Thr Val Gln Pro Ile Gln Leu Pro Glu Lys 
385                 390                 395                 400 


Asp Ser Trp Thr Val Asn Asp Ile Gln Lys Leu Val Gly Lys Leu Asn 
                405                 410                 415     


Trp Ala Ser Gln Ile Tyr Pro Gly Ile Lys Val Arg Gln Leu Cys Lys 
            420                 425                 430         


Leu Leu Arg Gly Ala Lys Ala Leu Thr Asp Ile Val Pro Leu Thr Glu 
        435                 440                 445             


Glu Ala Glu Leu Glu Leu Ala Glu Asn Arg Glu Ile Leu Lys Glu Pro 
    450                 455                 460                 


Val His Gly Val Tyr Tyr Asp Pro Ser Lys Asp Leu Ile Ala Glu Ile 
465                 470                 475                 480 


Gln Lys Gln Gly His Asp Gln Trp Thr Tyr Gln Ile Tyr Gln Glu Pro 
                485                 490                 495     


Phe Lys Asn Leu Lys Thr Gly Lys Tyr Ala Lys Met Arg Thr Ala His 
            500                 505                 510         


Thr Asn Asp Val Lys Gln Leu Thr Glu Ala Val Gln Lys Ile Ala Met 
        515                 520                 525             


Glu Ser Ile Val Ile Trp Gly Lys Thr Pro Lys Phe Arg Leu Pro Ile 
    530                 535                 540                 


Gln Lys Glu Thr Trp Glu Thr Trp Trp Thr Asp Tyr Trp Gln Ala Thr 
545                 550                 555                 560 


Trp Ile Pro Glu Trp Glu Phe Val Asn Thr Pro Pro Leu Val Lys Leu 
                565                 570                 575     


Trp Tyr Gln Leu Glu Lys Asp Pro Ile Ala Gly Val Glu Thr Phe Tyr 
            580                 585                 590         


Val Asp Gly Ala Ala Asn Arg Glu Thr Lys Leu Gly Lys Ala Gly Tyr 
        595                 600                 605             


Val Thr Asp Arg Gly Arg Gln Lys Ile Val Ser Leu Thr Glu Thr Thr 
    610                 615                 620                 


Asn Gln Lys Thr Glu Leu Gln Ala Ile Tyr Leu Ala Leu Gln Asp Ser 
625                 630                 635                 640 


Gly Ser Glu Val Asn Ile Val Thr Asp Ser Gln Tyr Ala Leu Gly Ile 
                645                 650                 655     


Ile Gln Ala Gln Pro Asp Lys Ser Glu Ser Glu Leu Val Asn Gln Ile 
            660                 665                 670         


Ile Glu Gln Leu Ile Lys Lys Glu Arg Val Tyr Leu Ser Trp Val Pro 
        675                 680                 685             


Ala His Lys Gly Ile Gly Gly Asn Glu Gln Val Asp Lys Leu Val Ser 
    690                 695                 700                 


Ser Gly Ile Arg Lys Val Leu Phe Leu Asp Gly Ile Asp Lys Ala Gln 
705                 710                 715                 720 


Glu Glu His Glu Lys Tyr His Ser Asn Trp Arg Ala Met Ala Ser Asp 
                725                 730                 735     


Phe Asn Leu Pro Pro Val Val Ala Lys Glu Ile Val Ala Ser Cys Asp 
            740                 745                 750         


Gln Cys Gln Leu Lys Gly Glu Ala Met His Gly Gln Val Asp Cys Ser 
        755                 760                 765             


Pro Gly Ile Trp Gln Leu Asp Cys Thr His Leu Glu Gly Lys Ile Ile 
    770                 775                 780                 


Leu Val Ala Val His Val Ala Ser Gly Tyr Ile Glu Ala Glu Val Ile 
785                 790                 795                 800 


Pro Ala Glu Thr Gly Gln Glu Thr Ala Tyr Phe Ile Leu Lys Leu Ala 
                805                 810                 815     


Gly Arg Trp Pro Val Lys Val Ile His Thr Asp Asn Gly Ser Asn Phe 
            820                 825                 830         


Thr Ser Ala Ala Val Lys Ala Ala Cys Trp Trp Ala Gly Ile Gln Gln 
        835                 840                 845             


Glu Phe Gly Ile Pro Tyr Asn Pro Gln Ser Gln Gly Val Val Glu Ser 
    850                 855                 860                 


Met Asn Lys Glu Leu Lys Lys Ile Ile Gly Gln Val Arg Asp Gln Ala 
865                 870                 875                 880 


Glu His Leu Lys Thr Ala Val Gln Met Ala Val Phe Ile His Asn Phe 
                885                 890                 895     


Lys Arg Lys Gly Gly Ile Gly Gly Tyr Ser Ala Gly Glu Arg Ile Ile 
            900                 905                 910         


Asp Ile Ile Ala Thr Asp Ile Gln Thr Lys Glu Leu Gln Lys Gln Ile 
        915                 920                 925             


Ile Lys Ile Gln Asn Phe Arg Val Tyr Tyr Arg Asp Ser Arg Asp Pro 
    930                 935                 940                 


Ile Trp Lys Gly Pro Ala Lys Leu Leu Trp Lys Gly Glu Gly Ala Val 
945                 950                 955                 960 


Val Ile Gln Asp Asn Ser Asp Ile Lys Val Val Pro Arg Arg Lys Val 
                965                 970                 975     


Lys Ile Ile Lys Asp Tyr Gly Lys Gln Met Ala Gly Ala Asp Cys Val 
            980                 985                 990         


Ala Gly Arg Gln Asp Glu Asp 
        995                 


<210>  13
<211>  1003
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mosaic pol2)

<400>  13

Phe Phe Arg Glu Asn Leu Ala Phe Pro Gln Gly Lys Ala Arg Glu Phe 
1               5                   10                  15      


Ser Ser Glu Gln Thr Arg Ala Asn Ser Pro Thr Arg Arg Glu Leu Gln 
            20                  25                  30          


Val Trp Gly Arg Asp Asn Asn Ser Leu Ser Glu Ala Gly Ala Asp Arg 
        35                  40                  45              


Gln Gly Thr Val Ser Phe Ser Phe Pro Gln Ile Thr Leu Trp Gln Arg 
    50                  55                  60                  


Pro Leu Val Thr Ile Lys Ile Gly Gly Gln Leu Lys Glu Ala Leu Leu 
65                  70                  75                  80  


Asp Thr Gly Ala Asp Asp Thr Val Leu Glu Glu Met Asn Leu Pro Gly 
                85                  90                  95      


Arg Trp Lys Pro Lys Met Ile Gly Gly Ile Gly Gly Phe Ile Lys Val 
            100                 105                 110         


Arg Gln Tyr Asp Gln Ile Pro Ile Glu Ile Cys Gly His Lys Ala Ile 
        115                 120                 125             


Gly Thr Val Leu Val Gly Pro Thr Pro Val Asn Ile Ile Gly Arg Asn 
    130                 135                 140                 


Leu Leu Thr Gln Ile Gly Cys Thr Leu Asn Phe Pro Ile Ser Pro Ile 
145                 150                 155                 160 


Glu Thr Val Pro Val Lys Leu Lys Pro Gly Met Asp Gly Pro Lys Val 
                165                 170                 175     


Lys Gln Trp Pro Leu Thr Glu Glu Lys Ile Lys Ala Leu Val Glu Ile 
            180                 185                 190         


Cys Thr Glu Met Glu Lys Glu Gly Lys Ile Ser Lys Ile Gly Pro Glu 
        195                 200                 205             


Asn Pro Tyr Asn Thr Pro Ile Phe Ala Ile Lys Lys Lys Asp Ser Thr 
    210                 215                 220                 


Lys Trp Arg Lys Leu Val Asp Phe Arg Glu Leu Asn Lys Arg Thr Gln 
225                 230                 235                 240 


Asp Phe Trp Glu Val Gln Leu Gly Ile Pro His Pro Ala Gly Leu Lys 
                245                 250                 255     


Lys Lys Lys Ser Val Thr Val Leu Asp Val Gly Asp Ala Tyr Phe Ser 
            260                 265                 270         


Val Pro Leu Asp Glu Asp Phe Arg Lys Tyr Thr Ala Phe Thr Ile Pro 
        275                 280                 285             


Ser Ile Asn Asn Glu Thr Pro Gly Ile Arg Tyr Gln Tyr Asn Val Leu 
    290                 295                 300                 


Pro Gln Gly Trp Lys Gly Ser Pro Ala Ile Phe Gln Ser Ser Met Thr 
305                 310                 315                 320 


Lys Ile Leu Glu Pro Phe Arg Lys Gln Asn Pro Asp Ile Val Ile Tyr 
                325                 330                 335     


Gln Tyr Met Asp Asp Leu Tyr Val Gly Ser Asp Leu Glu Ile Gly Gln 
            340                 345                 350         


His Arg Thr Lys Ile Glu Glu Leu Arg Gln His Leu Leu Arg Trp Gly 
        355                 360                 365             


Phe Thr Thr Pro Asp Lys Lys His Gln Lys Glu Pro Pro Phe Leu Trp 
    370                 375                 380                 


Met Gly Tyr Glu Leu His Pro Asp Lys Trp Thr Val Gln Pro Ile Val 
385                 390                 395                 400 


Leu Pro Glu Lys Asp Ser Trp Thr Val Asn Asp Ile Gln Lys Leu Val 
                405                 410                 415     


Gly Lys Leu Asn Trp Ala Ser Gln Ile Tyr Ala Gly Ile Lys Val Lys 
            420                 425                 430         


Gln Leu Cys Lys Leu Leu Arg Gly Thr Lys Ala Leu Thr Glu Val Val 
        435                 440                 445             


Pro Leu Thr Glu Glu Ala Glu Leu Glu Leu Ala Glu Asn Arg Glu Ile 
    450                 455                 460                 


Leu Lys Glu Pro Val His Gly Val Tyr Tyr Asp Pro Ser Lys Asp Leu 
465                 470                 475                 480 


Ile Ala Glu Ile Gln Lys Gln Gly Gln Gly Gln Trp Thr Tyr Gln Ile 
                485                 490                 495     


Tyr Gln Glu Pro Phe Lys Asn Leu Lys Thr Gly Lys Tyr Ala Arg Met 
            500                 505                 510         


Arg Gly Ala His Thr Asn Asp Val Lys Gln Leu Thr Glu Ala Val Gln 
        515                 520                 525             


Lys Ile Ala Thr Glu Ser Ile Val Ile Trp Gly Lys Thr Pro Lys Phe 
    530                 535                 540                 


Lys Leu Pro Ile Gln Lys Glu Thr Trp Glu Ala Trp Trp Thr Glu Tyr 
545                 550                 555                 560 


Trp Gln Ala Thr Trp Ile Pro Glu Trp Glu Phe Val Asn Thr Pro Pro 
                565                 570                 575     


Leu Val Lys Leu Trp Tyr Gln Leu Glu Lys Glu Pro Ile Val Gly Ala 
            580                 585                 590         


Glu Thr Phe Tyr Val Asp Gly Ala Ala Asn Arg Glu Thr Lys Leu Gly 
        595                 600                 605             


Lys Ala Gly Tyr Val Thr Asp Arg Gly Arg Gln Lys Val Val Ser Leu 
    610                 615                 620                 


Thr Asp Thr Thr Asn Gln Lys Thr Glu Leu Gln Ala Ile His Leu Ala 
625                 630                 635                 640 


Leu Gln Asp Ser Gly Leu Glu Val Asn Ile Val Thr Asp Ser Gln Tyr 
                645                 650                 655     


Ala Leu Gly Ile Ile Gln Ala Gln Pro Asp Lys Ser Glu Ser Glu Leu 
            660                 665                 670         


Val Ser Gln Ile Ile Glu Gln Leu Ile Lys Lys Glu Lys Val Tyr Leu 
        675                 680                 685             


Ala Trp Val Pro Ala His Lys Gly Ile Gly Gly Asn Glu Gln Val Asp 
    690                 695                 700                 


Lys Leu Val Ser Arg Gly Ile Arg Lys Val Leu Phe Leu Asp Gly Ile 
705                 710                 715                 720 


Asp Lys Ala Gln Glu Glu His Glu Lys Tyr His Ser Asn Trp Arg Ala 
                725                 730                 735     


Met Ala Ser Glu Phe Asn Leu Pro Pro Ile Val Ala Lys Glu Ile Val 
            740                 745                 750         


Ala Ser Cys Asp Lys Cys Gln Leu Lys Gly Glu Ala Ile His Gly Gln 
        755                 760                 765             


Val Asp Cys Ser Pro Gly Ile Trp Gln Leu Asp Cys Thr His Leu Glu 
    770                 775                 780                 


Gly Lys Val Ile Leu Val Ala Val His Val Ala Ser Gly Tyr Ile Glu 
785                 790                 795                 800 


Ala Glu Val Ile Pro Ala Glu Thr Gly Gln Glu Thr Ala Tyr Phe Leu 
                805                 810                 815     


Leu Lys Leu Ala Gly Arg Trp Pro Val Lys Thr Ile His Thr Asp Asn 
            820                 825                 830         


Gly Ser Asn Phe Thr Ser Ala Thr Val Lys Ala Ala Cys Trp Trp Ala 
        835                 840                 845             


Gly Ile Lys Gln Glu Phe Gly Ile Pro Tyr Asn Pro Gln Ser Gln Gly 
    850                 855                 860                 


Val Val Glu Ser Ile Asn Lys Glu Leu Lys Lys Ile Ile Gly Gln Val 
865                 870                 875                 880 


Arg Asp Gln Ala Glu His Leu Lys Thr Ala Val Gln Met Ala Val Phe 
                885                 890                 895     


Ile His Asn Phe Lys Arg Lys Gly Gly Ile Gly Glu Tyr Ser Ala Gly 
            900                 905                 910         


Glu Arg Ile Val Asp Ile Ile Ala Ser Asp Ile Gln Thr Lys Glu Leu 
        915                 920                 925             


Gln Lys Gln Ile Thr Lys Ile Gln Asn Phe Arg Val Tyr Tyr Arg Asp 
    930                 935                 940                 


Ser Arg Asp Pro Leu Trp Lys Gly Pro Ala Lys Leu Leu Trp Lys Gly 
945                 950                 955                 960 


Glu Gly Ala Val Val Ile Gln Asp Asn Ser Asp Ile Lys Val Val Pro 
                965                 970                 975     


Arg Arg Lys Ala Lys Ile Ile Arg Asp Tyr Gly Lys Gln Met Ala Gly 
            980                 985                 990         


Asp Asp Cys Val Ala Ser Arg Gln  Asp Glu Asp 
        995                 1000             


<210>  14
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mosaic nef1)

<400>  14

Met Gly Gly Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Ile 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Val Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Asn Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Arg Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Gly Ala Leu Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile Tyr Ser Gln Lys Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Val Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Phe Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Ile Glu Glu Ala Asn Glu Gly Glu 
145                 150                 155                 160 


Asn Asn Ser Leu Leu His Pro Met Ser Gln His Gly Met Asp Asp Pro 
                165                 170                 175     


Glu Lys Glu Val Leu Met Trp Lys Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Met Ala Arg Glu Leu His Pro Glu Tyr Tyr Lys Asp Cys 
        195                 200                 205     


<210>  15
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mosaic nef2)

<400>  15

Met Gly Gly Lys Trp Ser Lys Ser Ser Ile Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Ile Arg Arg Ala Glu Pro Ala Ala Glu Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Gln Asp Leu Asp Lys Tyr Gly Ala Leu Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Asp Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Lys Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Phe Asp Leu Ser Phe Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Asp Gly Leu Ile Tyr Ser Lys Lys Arg Gln Glu Ile Leu Asp Leu 
            100                 105                 110         


Trp Val Tyr Asn Thr Gln Gly Phe Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Phe Lys 
    130                 135                 140                 


Leu Val Pro Val Asp Pro Arg Glu Val Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Asn Cys Leu Leu His Pro Met Asn Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Glu Arg Glu Val Leu Val Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Met Ala Arg Glu Lys His Pro Glu Tyr Tyr Lys Asn Cys 
        195                 200                 205     


<210>  16
<211>  850
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mosaic pol1)

<400>  16

Met Ala Pro Ile Ser Pro Ile Glu Thr Val Pro Val Lys Leu Lys Pro 
1               5                   10                  15      


Gly Met Asp Gly Pro Arg Val Lys Gln Trp Pro Leu Thr Glu Glu Lys 
            20                  25                  30          


Ile Lys Ala Leu Thr Ala Ile Cys Glu Glu Met Glu Lys Glu Gly Lys 
        35                  40                  45              


Ile Thr Lys Ile Gly Pro Glu Asn Pro Tyr Asn Thr Pro Val Phe Ala 
    50                  55                  60                  


Ile Lys Lys Lys Asp Ser Thr Lys Trp Arg Lys Leu Val Asp Phe Arg 
65                  70                  75                  80  


Glu Leu Asn Lys Arg Thr Gln Asp Phe Trp Glu Val Gln Leu Gly Ile 
                85                  90                  95      


Pro His Pro Ala Gly Leu Lys Lys Lys Lys Ser Val Thr Val Leu Ala 
            100                 105                 110         


Val Gly Asp Ala Tyr Phe Ser Val Pro Leu Asp Glu Gly Phe Arg Lys 
        115                 120                 125             


Tyr Thr Ala Phe Thr Ile Pro Ser Thr Asn Asn Glu Thr Pro Gly Ile 
    130                 135                 140                 


Arg Tyr Gln Tyr Asn Val Leu Pro Gln Gly Trp Lys Gly Ser Pro Ala 
145                 150                 155                 160 


Ile Phe Gln Cys Ser Met Thr Arg Ile Leu Glu Pro Phe Arg Ala Lys 
                165                 170                 175     


Asn Pro Glu Ile Val Ile Tyr Gln Tyr Met Ala Ala Leu Tyr Val Gly 
            180                 185                 190         


Ser Asp Leu Glu Ile Gly Gln His Arg Ala Lys Ile Glu Glu Leu Arg 
        195                 200                 205             


Glu His Leu Leu Lys Trp Gly Phe Thr Thr Pro Asp Lys Lys His Gln 
    210                 215                 220                 


Lys Glu Pro Pro Phe Leu Trp Met Gly Tyr Glu Leu His Pro Asp Lys 
225                 230                 235                 240 


Trp Thr Val Gln Pro Ile Gln Leu Pro Glu Lys Asp Ser Trp Thr Val 
                245                 250                 255     


Asn Asp Ile Gln Lys Leu Val Gly Lys Leu Asn Trp Ala Ser Gln Ile 
            260                 265                 270         


Tyr Pro Gly Ile Lys Val Arg Gln Leu Cys Lys Leu Leu Arg Gly Ala 
        275                 280                 285             


Lys Ala Leu Thr Asp Ile Val Pro Leu Thr Glu Glu Ala Glu Leu Glu 
    290                 295                 300                 


Leu Ala Glu Asn Arg Glu Ile Leu Lys Glu Pro Val His Gly Val Tyr 
305                 310                 315                 320 


Tyr Asp Pro Ser Lys Asp Leu Ile Ala Glu Ile Gln Lys Gln Gly His 
                325                 330                 335     


Asp Gln Trp Thr Tyr Gln Ile Tyr Gln Glu Pro Phe Lys Asn Leu Lys 
            340                 345                 350         


Thr Gly Lys Tyr Ala Lys Met Arg Thr Ala His Thr Asn Asp Val Lys 
        355                 360                 365             


Gln Leu Thr Glu Ala Val Gln Lys Ile Ala Met Glu Ser Ile Val Ile 
    370                 375                 380                 


Trp Gly Lys Thr Pro Lys Phe Arg Leu Pro Ile Gln Lys Glu Thr Trp 
385                 390                 395                 400 


Glu Thr Trp Trp Thr Asp Tyr Trp Gln Ala Thr Trp Ile Pro Glu Trp 
                405                 410                 415     


Glu Phe Val Asn Thr Pro Pro Leu Val Lys Leu Trp Tyr Gln Leu Glu 
            420                 425                 430         


Lys Asp Pro Ile Ala Gly Val Glu Thr Phe Tyr Val Ala Gly Ala Ala 
        435                 440                 445             


Asn Arg Glu Thr Lys Leu Gly Lys Ala Gly Tyr Val Thr Asp Arg Gly 
    450                 455                 460                 


Arg Gln Lys Ile Val Ser Leu Thr Glu Thr Thr Asn Gln Lys Thr Ala 
465                 470                 475                 480 


Leu Gln Ala Ile Tyr Leu Ala Leu Gln Asp Ser Gly Ser Glu Val Asn 
                485                 490                 495     


Ile Val Thr Ala Ser Gln Tyr Ala Leu Gly Ile Ile Gln Ala Gln Pro 
            500                 505                 510         


Asp Lys Ser Glu Ser Glu Leu Val Asn Gln Ile Ile Glu Gln Leu Ile 
        515                 520                 525             


Lys Lys Glu Arg Val Tyr Leu Ser Trp Val Pro Ala His Lys Gly Ile 
    530                 535                 540                 


Gly Gly Asn Glu Gln Val Asp Lys Leu Val Ser Ser Gly Ile Arg Lys 
545                 550                 555                 560 


Val Leu Phe Leu Asp Gly Ile Asp Lys Ala Gln Glu Glu His Glu Lys 
                565                 570                 575     


Tyr His Ser Asn Trp Arg Ala Met Ala Ser Asp Phe Asn Leu Pro Pro 
            580                 585                 590         


Val Val Ala Lys Glu Ile Val Ala Ser Cys Asp Gln Cys Gln Leu Lys 
        595                 600                 605             


Gly Glu Ala Met His Gly Gln Val Asp Cys Ser Pro Gly Ile Trp Gln 
    610                 615                 620                 


Leu Ala Cys Thr His Leu Glu Gly Lys Ile Ile Leu Val Ala Val His 
625                 630                 635                 640 


Val Ala Ser Gly Tyr Ile Glu Ala Glu Val Ile Pro Ala Glu Thr Gly 
                645                 650                 655     


Gln Glu Thr Ala Tyr Phe Ile Leu Lys Leu Ala Gly Arg Trp Pro Val 
            660                 665                 670         


Lys Val Ile His Thr Ala Asn Gly Ser Asn Phe Thr Ser Ala Ala Val 
        675                 680                 685             


Lys Ala Ala Cys Trp Trp Ala Gly Ile Gln Gln Glu Phe Gly Ile Pro 
    690                 695                 700                 


Tyr Asn Pro Gln Ser Gln Gly Val Val Ala Ser Met Asn Lys Glu Leu 
705                 710                 715                 720 


Lys Lys Ile Ile Gly Gln Val Arg Asp Gln Ala Glu His Leu Lys Thr 
                725                 730                 735     


Ala Val Gln Met Ala Val Phe Ile His Asn Phe Lys Arg Lys Gly Gly 
            740                 745                 750         


Ile Gly Gly Tyr Ser Ala Gly Glu Arg Ile Ile Asp Ile Ile Ala Thr 
        755                 760                 765             


Asp Ile Gln Thr Lys Glu Leu Gln Lys Gln Ile Ile Lys Ile Gln Asn 
    770                 775                 780                 


Phe Arg Val Tyr Tyr Arg Asp Ser Arg Asp Pro Ile Trp Lys Gly Pro 
785                 790                 795                 800 


Ala Lys Leu Leu Trp Lys Gly Glu Gly Ala Val Val Ile Gln Asp Asn 
                805                 810                 815     


Ser Asp Ile Lys Val Val Pro Arg Arg Lys Val Lys Ile Ile Lys Asp 
            820                 825                 830         


Tyr Gly Lys Gln Met Ala Gly Ala Asp Cys Val Ala Gly Arg Gln Asp 
        835                 840                 845             


Glu Asp 
    850 


<210>  17
<211>  850
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mosaic pol1)

<400>  17

Met Ala Pro Ile Ser Pro Ile Glu Thr Val Pro Val Lys Leu Lys Pro 
1               5                   10                  15      


Gly Met Asp Gly Pro Lys Val Lys Gln Trp Pro Leu Thr Glu Glu Lys 
            20                  25                  30          


Ile Lys Ala Leu Val Glu Ile Cys Thr Glu Met Glu Lys Glu Gly Lys 
        35                  40                  45              


Ile Ser Lys Ile Gly Pro Glu Asn Pro Tyr Asn Thr Pro Ile Phe Ala 
    50                  55                  60                  


Ile Lys Lys Lys Asp Ser Thr Lys Trp Arg Lys Leu Val Asp Phe Arg 
65                  70                  75                  80  


Glu Leu Asn Lys Arg Thr Gln Asp Phe Trp Glu Val Gln Leu Gly Ile 
                85                  90                  95      


Pro His Pro Ala Gly Leu Lys Lys Lys Lys Ser Val Thr Val Leu Ala 
            100                 105                 110         


Val Gly Asp Ala Tyr Phe Ser Val Pro Leu Asp Glu Asp Phe Arg Lys 
        115                 120                 125             


Tyr Thr Ala Phe Thr Ile Pro Ser Ile Asn Asn Glu Thr Pro Gly Ile 
    130                 135                 140                 


Arg Tyr Gln Tyr Asn Val Leu Pro Gln Gly Trp Lys Gly Ser Pro Ala 
145                 150                 155                 160 


Ile Phe Gln Ser Ser Met Thr Lys Ile Leu Glu Pro Phe Arg Lys Gln 
                165                 170                 175     


Asn Pro Asp Ile Val Ile Tyr Gln Tyr Met Ala Ala Leu Tyr Val Gly 
            180                 185                 190         


Ser Asp Leu Glu Ile Gly Gln His Arg Thr Lys Ile Glu Glu Leu Arg 
        195                 200                 205             


Gln His Leu Leu Arg Trp Gly Phe Thr Thr Pro Asp Lys Lys His Gln 
    210                 215                 220                 


Lys Glu Pro Pro Phe Leu Trp Met Gly Tyr Glu Leu His Pro Asp Lys 
225                 230                 235                 240 


Trp Thr Val Gln Pro Ile Val Leu Pro Glu Lys Asp Ser Trp Thr Val 
                245                 250                 255     


Asn Asp Ile Gln Lys Leu Val Gly Lys Leu Asn Trp Ala Ser Gln Ile 
            260                 265                 270         


Tyr Ala Gly Ile Lys Val Lys Gln Leu Cys Lys Leu Leu Arg Gly Thr 
        275                 280                 285             


Lys Ala Leu Thr Glu Val Val Pro Leu Thr Glu Glu Ala Glu Leu Glu 
    290                 295                 300                 


Leu Ala Glu Asn Arg Glu Ile Leu Lys Glu Pro Val His Gly Val Tyr 
305                 310                 315                 320 


Tyr Asp Pro Ser Lys Asp Leu Ile Ala Glu Ile Gln Lys Gln Gly Gln 
                325                 330                 335     


Gly Gln Trp Thr Tyr Gln Ile Tyr Gln Glu Pro Phe Lys Asn Leu Lys 
            340                 345                 350         


Thr Gly Lys Tyr Ala Arg Met Arg Gly Ala His Thr Asn Asp Val Lys 
        355                 360                 365             


Gln Leu Thr Glu Ala Val Gln Lys Ile Ala Thr Glu Ser Ile Val Ile 
    370                 375                 380                 


Trp Gly Lys Thr Pro Lys Phe Lys Leu Pro Ile Gln Lys Glu Thr Trp 
385                 390                 395                 400 


Glu Ala Trp Trp Thr Glu Tyr Trp Gln Ala Thr Trp Ile Pro Glu Trp 
                405                 410                 415     


Glu Phe Val Asn Thr Pro Pro Leu Val Lys Leu Trp Tyr Gln Leu Glu 
            420                 425                 430         


Lys Glu Pro Ile Val Gly Ala Glu Thr Phe Tyr Val Ala Gly Ala Ala 
        435                 440                 445             


Asn Arg Glu Thr Lys Leu Gly Lys Ala Gly Tyr Val Thr Asp Arg Gly 
    450                 455                 460                 


Arg Gln Lys Val Val Ser Leu Thr Asp Thr Thr Asn Gln Lys Thr Ala 
465                 470                 475                 480 


Leu Gln Ala Ile His Leu Ala Leu Gln Asp Ser Gly Leu Glu Val Asn 
                485                 490                 495     


Ile Val Thr Ala Ser Gln Tyr Ala Leu Gly Ile Ile Gln Ala Gln Pro 
            500                 505                 510         


Asp Lys Ser Glu Ser Glu Leu Val Ser Gln Ile Ile Glu Gln Leu Ile 
        515                 520                 525             


Lys Lys Glu Lys Val Tyr Leu Ala Trp Val Pro Ala His Lys Gly Ile 
    530                 535                 540                 


Gly Gly Asn Glu Gln Val Asp Lys Leu Val Ser Arg Gly Ile Arg Lys 
545                 550                 555                 560 


Val Leu Phe Leu Asp Gly Ile Asp Lys Ala Gln Glu Glu His Glu Lys 
                565                 570                 575     


Tyr His Ser Asn Trp Arg Ala Met Ala Ser Glu Phe Asn Leu Pro Pro 
            580                 585                 590         


Ile Val Ala Lys Glu Ile Val Ala Ser Cys Asp Lys Cys Gln Leu Lys 
        595                 600                 605             


Gly Glu Ala Ile His Gly Gln Val Asp Cys Ser Pro Gly Ile Trp Gln 
    610                 615                 620                 


Leu Ala Cys Thr His Leu Glu Gly Lys Val Ile Leu Val Ala Val His 
625                 630                 635                 640 


Val Ala Ser Gly Tyr Ile Glu Ala Glu Val Ile Pro Ala Glu Thr Gly 
                645                 650                 655     


Gln Glu Thr Ala Tyr Phe Leu Leu Lys Leu Ala Gly Arg Trp Pro Val 
            660                 665                 670         


Lys Thr Ile His Thr Ala Asn Gly Ser Asn Phe Thr Ser Ala Thr Val 
        675                 680                 685             


Lys Ala Ala Cys Trp Trp Ala Gly Ile Lys Gln Glu Phe Gly Ile Pro 
    690                 695                 700                 


Tyr Asn Pro Gln Ser Gln Gly Val Val Ala Ser Ile Asn Lys Glu Leu 
705                 710                 715                 720 


Lys Lys Ile Ile Gly Gln Val Arg Asp Gln Ala Glu His Leu Lys Thr 
                725                 730                 735     


Ala Val Gln Met Ala Val Phe Ile His Asn Phe Lys Arg Lys Gly Gly 
            740                 745                 750         


Ile Gly Glu Tyr Ser Ala Gly Glu Arg Ile Val Asp Ile Ile Ala Ser 
        755                 760                 765             


Asp Ile Gln Thr Lys Glu Leu Gln Lys Gln Ile Thr Lys Ile Gln Asn 
    770                 775                 780                 


Phe Arg Val Tyr Tyr Arg Asp Ser Arg Asp Pro Leu Trp Lys Gly Pro 
785                 790                 795                 800 


Ala Lys Leu Leu Trp Lys Gly Glu Gly Ala Val Val Ile Gln Asp Asn 
                805                 810                 815     


Ser Asp Ile Lys Val Val Pro Arg Arg Lys Ala Lys Ile Ile Arg Asp 
            820                 825                 830         


Tyr Gly Lys Gln Met Ala Gly Asp Asp Cys Val Ala Ser Arg Gln Asp 
        835                 840                 845             


Glu Asp 
    850 


<210>  18
<211>  851
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mos3 pol v3)

<400>  18

Met Ala Pro Ile Ser Pro Ile Asp Thr Val Pro Val Thr Leu Lys Pro 
1               5                   10                  15      


Gly Met Asp Gly Pro Lys Ile Lys Gln Trp Pro Leu Thr Glu Glu Lys 
            20                  25                  30          


Ile Lys Ala Leu Thr Glu Ile Cys Thr Glu Met Glu Lys Glu Gly Lys 
        35                  40                  45              


Ile Ser Arg Ile Gly Pro Glu Asn Pro Tyr Asn Thr Pro Val Phe Ala 
    50                  55                  60                  


Ile Lys Lys Lys Asn Ser Thr Arg Trp Arg Lys Leu Val Asp Phe Arg 
65                  70                  75                  80  


Glu Leu Asn Lys Lys Thr Gln Asp Phe Trp Glu Val Gln Leu Gly Ile 
                85                  90                  95      


Pro His Pro Ala Gly Leu Lys Lys Lys Arg Ser Val Thr Val Leu Ala 
            100                 105                 110         


Val Gly Asp Ala Tyr Phe Ser Val Pro Leu Asp Lys Asp Phe Arg Lys 
        115                 120                 125             


Tyr Thr Ala Phe Thr Ile Pro Ser Val Asn Asn Glu Thr Pro Gly Val 
    130                 135                 140                 


Arg Tyr Gln Tyr Asn Val Leu Pro Gln Gly Trp Lys Gly Ser Pro Ala 
145                 150                 155                 160 


Ile Phe Gln Cys Ser Met Thr Lys Ile Leu Glu Pro Phe Arg Ala Gln 
                165                 170                 175     


Asn Pro Glu Ile Val Ile Tyr Gln Tyr Val Ala Ala Leu Tyr Val Gly 
            180                 185                 190         


Ser Asp Leu Glu Ile Glu Gln His Arg Thr Lys Ile Glu Glu Leu Arg 
        195                 200                 205             


Ala His Leu Leu Ser Trp Gly Phe Thr Thr Pro Asp Lys Lys His Gln 
    210                 215                 220                 


Arg Glu Pro Pro Phe Leu Trp Met Gly Tyr Glu Leu His Pro Asp Arg 
225                 230                 235                 240 


Trp Thr Val Gln Pro Ile Glu Leu Pro Glu Lys Glu Ser Trp Thr Val 
                245                 250                 255     


Asn Asp Ile Gln Lys Leu Val Gly Lys Leu Asn Trp Ala Ser Gln Ile 
            260                 265                 270         


Tyr Pro Gly Ile Lys Val Lys Gln Leu Cys Arg Leu Leu Arg Gly Ala 
        275                 280                 285             


Lys Ala Leu Thr Glu Val Ile Pro Leu Thr Lys Glu Ala Glu Leu Glu 
    290                 295                 300                 


Leu Ala Glu Asn Arg Glu Ile Leu Arg Glu Pro Val His Gly Val Tyr 
305                 310                 315                 320 


Tyr Asp Pro Ser Lys Asp Leu Val Ala Glu Ile Gln Lys Gln Gly Gln 
                325                 330                 335     


Asp Gln Trp Thr Tyr Gln Ile Tyr Gln Glu Pro Tyr Lys Asn Leu Lys 
            340                 345                 350         


Thr Gly Lys Tyr Ala Arg Lys Arg Ser Ala His Thr Asn Asp Val Arg 
        355                 360                 365             


Gln Leu Thr Glu Ala Val Gln Lys Ile Ala Leu Glu Ser Ile Val Ile 
    370                 375                 380                 


Trp Gly Lys Ile Pro Lys Phe Arg Leu Pro Ile Gln Arg Glu Thr Trp 
385                 390                 395                 400 


Glu Thr Trp Trp Thr Glu Tyr Trp Gln Ala Thr Trp Ile Pro Asp Trp 
                405                 410                 415     


Glu Phe Val Asn Thr Pro Pro Leu Val Lys Leu Trp Tyr Gln Leu Glu 
            420                 425                 430         


Lys Glu Pro Ile Ala Gly Ala Glu Thr Phe Tyr Val Ala Gly Ala Ser 
        435                 440                 445             


Asn Arg Glu Thr Lys Ile Gly Lys Ala Gly Tyr Val Thr Asp Lys Gly 
    450                 455                 460                 


Arg Gln Lys Val Val Ser Leu Thr Glu Thr Thr Asn Gln Lys Ala Ala 
465                 470                 475                 480 


Leu Gln Ala Ile Gln Leu Ala Leu Gln Asp Ser Gly Pro Glu Val Asn 
                485                 490                 495     


Ile Val Thr Ala Ser Gln Tyr Val Leu Gly Ile Ile Gln Ala Gln Pro 
            500                 505                 510         


Asp Arg Ser Glu Ser Glu Leu Val Asn Gln Ile Ile Glu Glu Leu Ile 
        515                 520                 525             


Lys Lys Glu Lys Val Tyr Leu Ser Trp Val Pro Ala His Lys Gly Ile 
    530                 535                 540                 


Gly Gly Asn Glu Gln Val Asp Lys Leu Val Ser Ala Gly Ile Arg Lys 
545                 550                 555                 560 


Ile Leu Phe Leu Asp Gly Ile Asp Lys Ala Gln Glu Glu His Glu Arg 
                565                 570                 575     


Tyr His Ser Asn Trp Arg Thr Met Ala Ser Asp Phe Asn Leu Pro Pro 
            580                 585                 590         


Ile Val Ala Lys Glu Ile Val Ala Asn Cys Asp Lys Cys Gln Leu Lys 
        595                 600                 605             


Gly Glu Ala Met His Gly Gln Val Asp Cys Ser Pro Gly Met Trp Gln 
    610                 615                 620                 


Leu Ala Cys Thr His Leu Glu Gly Lys Ile Ile Ile Val Ala Val His 
625                 630                 635                 640 


Val Ala Ser Gly Tyr Met Glu Ala Glu Val Ile Pro Ala Glu Thr Gly 
                645                 650                 655     


Gln Glu Thr Ala Tyr Tyr Ile Leu Lys Leu Ala Gly Arg Trp Pro Val 
            660                 665                 670         


Lys Val Val His Thr Ala Asn Gly Ser Asn Phe Thr Ser Thr Thr Val 
        675                 680                 685             


Lys Ala Ala Cys Trp Trp Ala Asn Val Thr Gln Glu Phe Gly Ile Pro 
    690                 695                 700                 


Tyr Asn Pro Gln Ser Gln Gly Val Ile Ala Ser Met Asn Lys Glu Leu 
705                 710                 715                 720 


Lys Lys Ile Ile Gly Gln Val Arg Glu Gln Ala Glu His Leu Lys Thr 
                725                 730                 735     


Ala Val Gln Met Ala Val Leu Ile His Asn Phe Lys Arg Arg Gly Gly 
            740                 745                 750         


Ile Gly Gly Tyr Ser Ala Gly Glu Arg Ile Val Asp Ile Ile Ala Thr 
        755                 760                 765             


Asp Ile Gln Thr Arg Glu Leu Gln Lys Gln Ile Ile Lys Ile Gln Asn 
    770                 775                 780                 


Phe Arg Val Tyr Phe Arg Asp Ser Arg Asp Pro Val Trp Lys Gly Pro 
785                 790                 795                 800 


Ala Lys Leu Leu Trp Lys Gly Glu Gly Ala Val Val Ile Gln Asp Asn 
                805                 810                 815     


Ser Glu Ile Lys Val Val Pro Arg Arg Lys Val Lys Ile Ile Arg Asp 
            820                 825                 830         


Tyr Gly Lys Gln Met Ala Gly Asp Asp Cys Val Ala Gly Arg Gln Asp 
        835                 840                 845             


Glu Asp Gln 
    850     


<210>  19
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mos3 gag)

<400>  19

Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Lys Leu Asp Ala Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys 
            20                  25                  30          


His Ile Val Trp Ala Ser Arg Glu Leu Asp Arg Phe Ala Leu Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Ala Glu Gly Cys Gln Gln Ile Ile Glu Gln Leu 
    50                  55                  60                  


Gln Pro Ala Leu Gln Thr Gly Ser Glu Glu Leu Lys Ser Leu Tyr Asn 
65                  70                  75                  80  


Thr Val Ala Val Leu Tyr Cys Val His Gln Arg Ile Asp Val Lys Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Ile Gln Asn Lys Ser Lys 
            100                 105                 110         


Gln Lys Thr Gln Gln Ala Ala Ala Asp Thr Gly Ser Ser Ser Lys Val 
        115                 120                 125             


Ser Gln Asn Tyr Pro Ile Val Gln Asn Ala Gln Gly Gln Met Val His 
    130                 135                 140                 


Gln Ala Leu Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 
145                 150                 155                 160 


Glu Lys Gly Phe Asn Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ala 
                165                 170                 175     


Glu Gly Ala Thr Pro Gln Asp Leu Asn Met Met Leu Asn Ile Val Gly 
            180                 185                 190         


Gly His Gln Ala Ala Met Gln Ile Leu Lys Asp Thr Ile Asn Glu Glu 
        195                 200                 205             


Ala Ala Asp Trp Asp Arg Leu His Pro Val His Ala Gly Pro Ile Pro 
    210                 215                 220                 


Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 
225                 230                 235                 240 


Ser Thr Pro Gln Glu Gln Ile Gly Trp Met Thr Ser Asn Pro Pro Val 
                245                 250                 255     


Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Met Gly Leu Asn Lys 
            260                 265                 270         


Ile Val Arg Met Tyr Ser Pro Val Ser Ile Leu Asp Ile Lys Gln Gly 
        275                 280                 285             


Pro Lys Glu Ser Phe Arg Asp Tyr Val Asp Arg Phe Phe Lys Val Leu 
    290                 295                 300                 


Arg Ala Glu Gln Ala Thr Gln Glu Val Lys Asn Trp Met Thr Glu Thr 
305                 310                 315                 320 


Leu Leu Ile Gln Asn Ala Asn Pro Asp Cys Lys Ser Ile Leu Arg Ala 
                325                 330                 335     


Leu Gly Pro Gly Ala Ser Leu Glu Glu Met Met Thr Ala Cys Gln Gly 
            340                 345                 350         


Val Gly Gly Pro Ser His Lys Ala Arg Ile Leu Ala Glu Ala Met Ser 
        355                 360                 365             


Gln Ala Asn Asn Thr Asn Ile Met Met Gln Arg Gly Asn Phe Lys Gly 
    370                 375                 380                 


Gln Lys Arg Ile Lys Cys Phe Asn Cys Gly Lys Glu Gly His Leu Ala 
385                 390                 395                 400 


Arg Asn Cys Arg Ala Pro Arg Lys Arg Gly Cys Trp Lys Cys Gly Arg 
                405                 410                 415     


Glu Gly His Gln Met Lys Asp Cys Asn Glu Arg Gln Ala Asn Phe Leu 
            420                 425                 430         


Gly Lys Ile Trp Pro Ser Ser Lys Gly Arg Pro Gly Asn Phe Pro Gln 
        435                 440                 445             


Ser Arg Pro Glu Pro Thr Ala Pro Leu Glu Pro Thr Ala Pro Pro Ala 
    450                 455                 460                 


Glu Pro Thr Ala Pro Pro Ala Glu Ser Phe Gly Phe Gly Glu Glu Ile 
465                 470                 475                 480 


Thr Pro Ser Pro Lys Gln Glu Gln Lys Asp Arg Glu Pro Leu Thr Ser 
                485                 490                 495     


Leu Lys Ser Leu Phe Gly Ser Asp Pro Leu Leu Gln 
            500                 505             


<210>  20
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct ((Mos1 nef) (G to A to delete myristylation 
       site))

<400>  20

Met Ala Gly Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Ile 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Val Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Asn Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Arg Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Gly Ala Leu Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile Tyr Ser Gln Lys Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Val Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Phe Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Ile Glu Glu Ala Asn Glu Gly Glu 
145                 150                 155                 160 


Asn Asn Ser Leu Leu His Pro Met Ser Gln His Gly Met Asp Asp Pro 
                165                 170                 175     


Glu Lys Glu Val Leu Met Trp Lys Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Met Ala Arg Glu Leu His Pro Glu Tyr Tyr Lys Asp Cys 
        195                 200                 205     


<210>  21
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct ((Mos2 nef) (G to A to delete myristylation))

<400>  21

Met Ala Gly Lys Trp Ser Lys Ser Ser Ile Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Ile Arg Arg Ala Glu Pro Ala Ala Glu Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Gln Asp Leu Asp Lys Tyr Gly Ala Leu Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Asp Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Lys Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Phe Asp Leu Ser Phe Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Asp Gly Leu Ile Tyr Ser Lys Lys Arg Gln Glu Ile Leu Asp Leu 
            100                 105                 110         


Trp Val Tyr Asn Thr Gln Gly Phe Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Phe Lys 
    130                 135                 140                 


Leu Val Pro Val Asp Pro Arg Glu Val Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Asn Cys Leu Leu His Pro Met Asn Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Glu Arg Glu Val Leu Val Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Met Ala Arg Glu Lys His Pro Glu Tyr Tyr Lys Asn Cys 
        195                 200                 205     


<210>  22
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mos3 nef)

<400>  22

Met Ala Gly Lys Trp Ser Lys Arg Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Thr Glu Pro Ala Ala Glu Gly Val Gly Ala 
            20                  25                  30          


Val Ser Gln Asp Leu Asp Lys His Gly Ala Leu Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala His Asn Asn Ala Asp Cys Ala Trp Leu Gln Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Glu Val Gly Phe Pro Val Arg Pro Gln Val Pro Val Arg Pro Met 
65                  70                  75                  80  


Thr Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly 
                85                  90                  95      


Gly Leu Glu Gly Leu Ile His Ser Gln Lys Arg Gln Glu Ile Leu Asp 
            100                 105                 110         


Leu Trp Val Tyr His Thr Gln Gly Phe Phe Pro Asp Trp His Asn Tyr 
        115                 120                 125             


Thr Pro Gly Pro Gly Thr Arg Phe Pro Leu Thr Phe Gly Trp Cys Tyr 
    130                 135                 140                 


Lys Leu Val Pro Val Asp Pro Lys Glu Val Glu Glu Ala Asn Glu Gly 
145                 150                 155                 160 


Glu Asn Asn Cys Leu Leu His Pro Met Ser Gln His Gly Met Glu Asp 
                165                 170                 175     


Glu Asp Arg Glu Val Leu Lys Trp Lys Phe Asp Ser Ser Leu Ala Arg 
            180                 185                 190         


Arg His Met Ala Arg Glu Leu His Pro Glu Phe Tyr Lys Asp Cys Leu 
        195                 200                 205             


<210>  23
<211>  705
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mosaic gagnef1)

<400>  23

Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Arg Leu Lys 
            20                  25                  30          


His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 
    50                  55                  60                  


Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 
65                  70                  75                  80  


Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Glu Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 
            100                 105                 110         


Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly Asn Ser Ser Gln Val 
        115                 120                 125             


Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 
    130                 135                 140                 


Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 
145                 150                 155                 160 


Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 
                165                 170                 175     


Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 
            180                 185                 190         


Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 
        195                 200                 205             


Ala Ala Glu Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala 
    210                 215                 220                 


Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 
225                 230                 235                 240 


Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 
                245                 250                 255     


Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 
            260                 265                 270         


Ile Val Arg Met Tyr Ser Pro Val Ser Ile Leu Asp Ile Arg Gln Gly 
        275                 280                 285             


Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 
    290                 295                 300                 


Arg Ala Glu Gln Ala Ser Gln Asp Val Lys Asn Trp Met Thr Glu Thr 
305                 310                 315                 320 


Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 
                325                 330                 335     


Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 
            340                 345                 350         


Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met Ser 
        355                 360                 365             


Gln Val Thr Asn Ser Ala Thr Ile Met Met Gln Arg Gly Asn Phe Arg 
    370                 375                 380                 


Asn Gln Arg Lys Thr Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His 
385                 390                 395                 400 


Ile Ala Lys Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys 
                405                 410                 415     


Gly Lys Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn 
            420                 425                 430         


Phe Leu Gly Lys Ile Trp Pro Ser Asn Lys Gly Arg Pro Gly Asn Phe 
        435                 440                 445             


Leu Gln Asn Arg Pro Glu Pro Thr Ala Pro Pro Glu Glu Ser Phe Arg 
    450                 455                 460                 


Phe Gly Glu Glu Thr Thr Thr Pro Ser Gln Lys Gln Glu Pro Ile Asp 
465                 470                 475                 480 


Lys Glu Met Tyr Pro Leu Ala Ser Leu Lys Ser Leu Phe Gly Asn Asp 
                485                 490                 495     


Pro Ser Ser Gln Ala Gly Lys Trp Ser Lys Ser Ser Val Val Gly Trp 
            500                 505                 510         


Pro Ala Ile Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly 
        515                 520                 525             


Val Gly Ala Val Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser 
    530                 535                 540                 


Ser Asn Thr Ala Ala Asn Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln 
545                 550                 555                 560 


Glu Glu Glu Glu Val Gly Phe Pro Val Arg Pro Gln Val Pro Leu Arg 
                565                 570                 575     


Pro Met Thr Tyr Lys Gly Ala Leu Asp Leu Ser His Phe Leu Lys Glu 
            580                 585                 590         


Lys Gly Gly Leu Glu Gly Leu Ile Tyr Ser Gln Lys Arg Gln Asp Ile 
        595                 600                 605             


Leu Asp Leu Trp Val Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln 
    610                 615                 620                 


Asn Tyr Thr Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp 
625                 630                 635                 640 


Cys Phe Lys Leu Val Pro Val Glu Pro Glu Lys Ile Glu Glu Ala Asn 
                645                 650                 655     


Glu Gly Glu Asn Asn Ser Leu Leu His Pro Met Ser Gln His Gly Met 
            660                 665                 670         


Asp Asp Pro Glu Lys Glu Val Leu Met Trp Lys Phe Asp Ser Arg Leu 
        675                 680                 685             


Ala Phe His His Met Ala Arg Glu Leu His Pro Glu Tyr Tyr Lys Asp 
    690                 695                 700                 


Cys 
705 


<210>  24
<211>  696
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mosaic gagnef2)

<400>  24

Met Gly Ala Arg Ala Ser Ile Leu Arg Gly Gly Lys Leu Asp Lys Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys His Tyr Met Leu Lys 
            20                  25                  30          


His Leu Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Leu Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Ser Glu Gly Cys Lys Gln Ile Ile Lys Gln Leu 
    50                  55                  60                  


Gln Pro Ala Leu Gln Thr Gly Thr Glu Glu Leu Arg Ser Leu Phe Asn 
65                  70                  75                  80  


Thr Val Ala Thr Leu Tyr Cys Val His Ala Glu Ile Glu Val Arg Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Gln 
            100                 105                 110         


Gln Lys Thr Gln Gln Ala Lys Glu Ala Asp Gly Lys Val Ser Gln Asn 
        115                 120                 125             


Tyr Pro Ile Val Gln Asn Leu Gln Gly Gln Met Val His Gln Pro Ile 
    130                 135                 140                 


Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Ile Glu Glu Lys Ala 
145                 150                 155                 160 


Phe Ser Pro Glu Val Ile Pro Met Phe Thr Ala Leu Ser Glu Gly Ala 
                165                 170                 175     


Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly Gly His Gln 
            180                 185                 190         


Ala Ala Met Gln Met Leu Lys Asp Thr Ile Asn Glu Glu Ala Ala Glu 
        195                 200                 205             


Trp Asp Arg Leu His Pro Val His Ala Gly Pro Val Ala Pro Gly Gln 
    210                 215                 220                 


Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr Ser Asn Leu 
225                 230                 235                 240 


Gln Glu Gln Ile Ala Trp Met Thr Ser Asn Pro Pro Ile Pro Val Gly 
                245                 250                 255     


Asp Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg 
            260                 265                 270         


Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Lys Gln Gly Pro Lys Glu 
        275                 280                 285             


Pro Phe Arg Asp Tyr Val Asp Arg Phe Phe Lys Thr Leu Arg Ala Glu 
    290                 295                 300                 


Gln Ala Thr Gln Asp Val Lys Asn Trp Met Thr Asp Thr Leu Leu Val 
305                 310                 315                 320 


Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Arg Ala Leu Gly Pro 
                325                 330                 335     


Gly Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly Val Gly Gly 
            340                 345                 350         


Pro Ser His Lys Ala Arg Val Leu Ala Glu Ala Met Ser Gln Thr Asn 
        355                 360                 365             


Ser Thr Ile Leu Met Gln Arg Ser Asn Phe Lys Gly Ser Lys Arg Ile 
    370                 375                 380                 


Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His Ile Ala Arg Asn Cys 
385                 390                 395                 400 


Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys Gly Lys Glu Gly His 
                405                 410                 415     


Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn Phe Leu Gly Lys Ile 
            420                 425                 430         


Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe Leu Gln Ser Arg Pro 
        435                 440                 445             


Glu Pro Thr Ala Pro Pro Ala Glu Ser Phe Arg Phe Glu Glu Thr Thr 
    450                 455                 460                 


Pro Ala Pro Lys Gln Glu Pro Lys Asp Arg Glu Pro Leu Thr Ser Leu 
465                 470                 475                 480 


Arg Ser Leu Phe Gly Ser Asp Pro Leu Ser Gln Ala Gly Lys Trp Ser 
                485                 490                 495     


Lys Ser Ser Ile Val Gly Trp Pro Ala Val Arg Glu Arg Ile Arg Arg 
            500                 505                 510         


Ala Glu Pro Ala Ala Glu Gly Val Gly Ala Ala Ser Gln Asp Leu Asp 
        515                 520                 525             


Lys Tyr Gly Ala Leu Thr Ser Ser Asn Thr Ala Ala Thr Asn Ala Asp 
    530                 535                 540                 


Cys Ala Trp Leu Glu Ala Gln Glu Asp Glu Glu Val Gly Phe Pro Val 
545                 550                 555                 560 


Lys Pro Gln Val Pro Leu Arg Pro Met Thr Tyr Lys Ala Ala Phe Asp 
                565                 570                 575     


Leu Ser Phe Phe Leu Lys Glu Lys Gly Gly Leu Asp Gly Leu Ile Tyr 
            580                 585                 590         


Ser Lys Lys Arg Gln Glu Ile Leu Asp Leu Trp Val Tyr Asn Thr Gln 
        595                 600                 605             


Gly Phe Phe Pro Asp Trp Gln Asn Tyr Thr Pro Gly Pro Gly Val Arg 
    610                 615                 620                 


Tyr Pro Leu Thr Phe Gly Trp Cys Phe Lys Leu Val Pro Val Asp Pro 
625                 630                 635                 640 


Arg Glu Val Glu Glu Ala Asn Lys Gly Glu Asn Asn Cys Leu Leu His 
                645                 650                 655     


Pro Met Asn Leu His Gly Met Asp Asp Pro Glu Arg Glu Val Leu Val 
            660                 665                 670         


Trp Arg Phe Asp Ser Arg Leu Ala Phe His His Met Ala Arg Glu Lys 
        675                 680                 685             


His Pro Glu Tyr Tyr Lys Asn Cys 
    690                 695     


<210>  25
<211>  1341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mosaic gag pol2 v3)

<400>  25

Met Gly Ala Arg Ala Ser Ile Leu Arg Gly Gly Lys Leu Asp Lys Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys His Tyr Met Leu Lys 
            20                  25                  30          


His Leu Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Leu Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Ser Glu Gly Cys Lys Gln Ile Ile Lys Gln Leu 
    50                  55                  60                  


Gln Pro Ala Leu Gln Thr Gly Thr Glu Glu Leu Arg Ser Leu Phe Asn 
65                  70                  75                  80  


Thr Val Ala Thr Leu Tyr Cys Val His Ala Glu Ile Glu Val Arg Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Gln 
            100                 105                 110         


Gln Lys Thr Gln Gln Ala Lys Glu Ala Asp Gly Lys Val Ser Gln Asn 
        115                 120                 125             


Tyr Pro Ile Val Gln Asn Leu Gln Gly Gln Met Val His Gln Pro Ile 
    130                 135                 140                 


Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Ile Glu Glu Lys Ala 
145                 150                 155                 160 


Phe Ser Pro Glu Val Ile Pro Met Phe Thr Ala Leu Ser Glu Gly Ala 
                165                 170                 175     


Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly Gly His Gln 
            180                 185                 190         


Ala Ala Met Gln Met Leu Lys Asp Thr Ile Asn Glu Glu Ala Ala Glu 
        195                 200                 205             


Trp Asp Arg Leu His Pro Val His Ala Gly Pro Val Ala Pro Gly Gln 
    210                 215                 220                 


Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr Ser Asn Leu 
225                 230                 235                 240 


Gln Glu Gln Ile Ala Trp Met Thr Ser Asn Pro Pro Ile Pro Val Gly 
                245                 250                 255     


Asp Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg 
            260                 265                 270         


Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Lys Gln Gly Pro Lys Glu 
        275                 280                 285             


Pro Phe Arg Asp Tyr Val Asp Arg Phe Phe Lys Thr Leu Arg Ala Glu 
    290                 295                 300                 


Gln Ala Thr Gln Asp Val Lys Asn Trp Met Thr Asp Thr Leu Leu Val 
305                 310                 315                 320 


Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Arg Ala Leu Gly Pro 
                325                 330                 335     


Gly Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly Val Gly Gly 
            340                 345                 350         


Pro Ser His Lys Ala Arg Val Leu Ala Glu Ala Met Ser Gln Thr Asn 
        355                 360                 365             


Ser Thr Ile Leu Met Gln Arg Ser Asn Phe Lys Gly Ser Lys Arg Ile 
    370                 375                 380                 


Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His Ile Ala Arg Asn Cys 
385                 390                 395                 400 


Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys Gly Lys Glu Gly His 
                405                 410                 415     


Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn Phe Leu Gly Lys Ile 
            420                 425                 430         


Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe Leu Gln Ser Arg Pro 
        435                 440                 445             


Glu Pro Thr Ala Pro Pro Ala Glu Ser Phe Arg Phe Glu Glu Thr Thr 
    450                 455                 460                 


Pro Ala Pro Lys Gln Glu Pro Lys Asp Arg Glu Pro Leu Thr Ser Leu 
465                 470                 475                 480 


Arg Ser Leu Phe Gly Ser Asp Pro Leu Ser Gln Met Ala Pro Ile Ser 
                485                 490                 495     


Pro Ile Glu Thr Val Pro Val Lys Leu Lys Pro Gly Met Asp Gly Pro 
            500                 505                 510         


Lys Val Lys Gln Trp Pro Leu Thr Glu Glu Lys Ile Lys Ala Leu Val 
        515                 520                 525             


Glu Ile Cys Thr Glu Met Glu Lys Glu Gly Lys Ile Ser Lys Ile Gly 
    530                 535                 540                 


Pro Glu Asn Pro Tyr Asn Thr Pro Ile Phe Ala Ile Lys Lys Lys Asp 
545                 550                 555                 560 


Ser Thr Lys Trp Arg Lys Leu Val Asp Phe Arg Glu Leu Asn Lys Arg 
                565                 570                 575     


Thr Gln Asp Phe Trp Glu Val Gln Leu Gly Ile Pro His Pro Ala Gly 
            580                 585                 590         


Leu Lys Lys Lys Lys Ser Val Thr Val Leu Ala Val Gly Asp Ala Tyr 
        595                 600                 605             


Phe Ser Val Pro Leu Asp Glu Asp Phe Arg Lys Tyr Thr Ala Phe Thr 
    610                 615                 620                 


Ile Pro Ser Ile Asn Asn Glu Thr Pro Gly Ile Arg Tyr Gln Tyr Asn 
625                 630                 635                 640 


Val Leu Pro Gln Gly Trp Lys Gly Ser Pro Ala Ile Phe Gln Ser Ser 
                645                 650                 655     


Met Thr Lys Ile Leu Glu Pro Phe Arg Lys Gln Asn Pro Asp Ile Val 
            660                 665                 670         


Ile Tyr Gln Tyr Met Ala Ala Leu Tyr Val Gly Ser Asp Leu Glu Ile 
        675                 680                 685             


Gly Gln His Arg Thr Lys Ile Glu Glu Leu Arg Gln His Leu Leu Arg 
    690                 695                 700                 


Trp Gly Phe Thr Thr Pro Asp Lys Lys His Gln Lys Glu Pro Pro Phe 
705                 710                 715                 720 


Leu Trp Met Gly Tyr Glu Leu His Pro Asp Lys Trp Thr Val Gln Pro 
                725                 730                 735     


Ile Val Leu Pro Glu Lys Asp Ser Trp Thr Val Asn Asp Ile Gln Lys 
            740                 745                 750         


Leu Val Gly Lys Leu Asn Trp Ala Ser Gln Ile Tyr Ala Gly Ile Lys 
        755                 760                 765             


Val Lys Gln Leu Cys Lys Leu Leu Arg Gly Thr Lys Ala Leu Thr Glu 
    770                 775                 780                 


Val Val Pro Leu Thr Glu Glu Ala Glu Leu Glu Leu Ala Glu Asn Arg 
785                 790                 795                 800 


Glu Ile Leu Lys Glu Pro Val His Gly Val Tyr Tyr Asp Pro Ser Lys 
                805                 810                 815     


Asp Leu Ile Ala Glu Ile Gln Lys Gln Gly Gln Gly Gln Trp Thr Tyr 
            820                 825                 830         


Gln Ile Tyr Gln Glu Pro Phe Lys Asn Leu Lys Thr Gly Lys Tyr Ala 
        835                 840                 845             


Arg Met Arg Gly Ala His Thr Asn Asp Val Lys Gln Leu Thr Glu Ala 
    850                 855                 860                 


Val Gln Lys Ile Ala Thr Glu Ser Ile Val Ile Trp Gly Lys Thr Pro 
865                 870                 875                 880 


Lys Phe Lys Leu Pro Ile Gln Lys Glu Thr Trp Glu Ala Trp Trp Thr 
                885                 890                 895     


Glu Tyr Trp Gln Ala Thr Trp Ile Pro Glu Trp Glu Phe Val Asn Thr 
            900                 905                 910         


Pro Pro Leu Val Lys Leu Trp Tyr Gln Leu Glu Lys Glu Pro Ile Val 
        915                 920                 925             


Gly Ala Glu Thr Phe Tyr Val Ala Gly Ala Ala Asn Arg Glu Thr Lys 
    930                 935                 940                 


Leu Gly Lys Ala Gly Tyr Val Thr Asp Arg Gly Arg Gln Lys Val Val 
945                 950                 955                 960 


Ser Leu Thr Asp Thr Thr Asn Gln Lys Thr Ala Leu Gln Ala Ile His 
                965                 970                 975     


Leu Ala Leu Gln Asp Ser Gly Leu Glu Val Asn Ile Val Thr Ala Ser 
            980                 985                 990         


Gln Tyr Ala Leu Gly Ile Ile Gln  Ala Gln Pro Asp Lys  Ser Glu Ser 
        995                 1000                 1005             


Glu Leu  Val Ser Gln Ile Ile  Glu Gln Leu Ile Lys  Lys Glu Lys 
    1010                 1015                 1020             


Val Tyr  Leu Ala Trp Val Pro  Ala His Lys Gly Ile  Gly Gly Asn 
    1025                 1030                 1035             


Glu Gln  Val Asp Lys Leu Val  Ser Arg Gly Ile Arg  Lys Val Leu 
    1040                 1045                 1050             


Phe Leu  Asp Gly Ile Asp Lys  Ala Gln Glu Glu His  Glu Lys Tyr 
    1055                 1060                 1065             


His Ser  Asn Trp Arg Ala Met  Ala Ser Glu Phe Asn  Leu Pro Pro 
    1070                 1075                 1080             


Ile Val  Ala Lys Glu Ile Val  Ala Ser Cys Asp Lys  Cys Gln Leu 
    1085                 1090                 1095             


Lys Gly  Glu Ala Ile His Gly  Gln Val Asp Cys Ser  Pro Gly Ile 
    1100                 1105                 1110             


Trp Gln  Leu Ala Cys Thr His  Leu Glu Gly Lys Val  Ile Leu Val 
    1115                 1120                 1125             


Ala Val  His Val Ala Ser Gly  Tyr Ile Glu Ala Glu  Val Ile Pro 
    1130                 1135                 1140             


Ala Glu  Thr Gly Gln Glu Thr  Ala Tyr Phe Leu Leu  Lys Leu Ala 
    1145                 1150                 1155             


Gly Arg  Trp Pro Val Lys Thr  Ile His Thr Ala Asn  Gly Ser Asn 
    1160                 1165                 1170             


Phe Thr  Ser Ala Thr Val Lys  Ala Ala Cys Trp Trp  Ala Gly Ile 
    1175                 1180                 1185             


Lys Gln  Glu Phe Gly Ile Pro  Tyr Asn Pro Gln Ser  Gln Gly Val 
    1190                 1195                 1200             


Val Ala  Ser Ile Asn Lys Glu  Leu Lys Lys Ile Ile  Gly Gln Val 
    1205                 1210                 1215             


Arg Asp  Gln Ala Glu His Leu  Lys Thr Ala Val Gln  Met Ala Val 
    1220                 1225                 1230             


Phe Ile  His Asn Phe Lys Arg  Lys Gly Gly Ile Gly  Glu Tyr Ser 
    1235                 1240                 1245             


Ala Gly  Glu Arg Ile Val Asp  Ile Ile Ala Ser Asp  Ile Gln Thr 
    1250                 1255                 1260             


Lys Glu  Leu Gln Lys Gln Ile  Thr Lys Ile Gln Asn  Phe Arg Val 
    1265                 1270                 1275             


Tyr Tyr  Arg Asp Ser Arg Asp  Pro Leu Trp Lys Gly  Pro Ala Lys 
    1280                 1285                 1290             


Leu Leu  Trp Lys Gly Glu Gly  Ala Val Val Ile Gln  Asp Asn Ser 
    1295                 1300                 1305             


Asp Ile  Lys Val Val Pro Arg  Arg Lys Ala Lys Ile  Ile Arg Asp 
    1310                 1315                 1320             


Tyr Gly  Lys Gln Met Ala Gly  Asp Asp Cys Val Ala  Ser Arg Gln 
    1325                 1330                 1335             


Asp Glu  Asp 
    1340     


<210>  26
<211>  1359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mos3 gag-pol v3)

<400>  26

Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Lys Leu Asp Ala Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys 
            20                  25                  30          


His Ile Val Trp Ala Ser Arg Glu Leu Asp Arg Phe Ala Leu Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Ala Glu Gly Cys Gln Gln Ile Ile Glu Gln Leu 
    50                  55                  60                  


Gln Pro Ala Leu Gln Thr Gly Ser Glu Glu Leu Lys Ser Leu Tyr Asn 
65                  70                  75                  80  


Thr Val Ala Val Leu Tyr Cys Val His Gln Arg Ile Asp Val Lys Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Ile Gln Asn Lys Ser Lys 
            100                 105                 110         


Gln Lys Thr Gln Gln Ala Ala Ala Asp Thr Gly Ser Ser Ser Lys Val 
        115                 120                 125             


Ser Gln Asn Tyr Pro Ile Val Gln Asn Ala Gln Gly Gln Met Val His 
    130                 135                 140                 


Gln Ala Leu Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 
145                 150                 155                 160 


Glu Lys Gly Phe Asn Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ala 
                165                 170                 175     


Glu Gly Ala Thr Pro Gln Asp Leu Asn Met Met Leu Asn Ile Val Gly 
            180                 185                 190         


Gly His Gln Ala Ala Met Gln Ile Leu Lys Asp Thr Ile Asn Glu Glu 
        195                 200                 205             


Ala Ala Asp Trp Asp Arg Leu His Pro Val His Ala Gly Pro Ile Pro 
    210                 215                 220                 


Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 
225                 230                 235                 240 


Ser Thr Pro Gln Glu Gln Ile Gly Trp Met Thr Ser Asn Pro Pro Val 
                245                 250                 255     


Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Met Gly Leu Asn Lys 
            260                 265                 270         


Ile Val Arg Met Tyr Ser Pro Val Ser Ile Leu Asp Ile Lys Gln Gly 
        275                 280                 285             


Pro Lys Glu Ser Phe Arg Asp Tyr Val Asp Arg Phe Phe Lys Val Leu 
    290                 295                 300                 


Arg Ala Glu Gln Ala Thr Gln Glu Val Lys Asn Trp Met Thr Glu Thr 
305                 310                 315                 320 


Leu Leu Ile Gln Asn Ala Asn Pro Asp Cys Lys Ser Ile Leu Arg Ala 
                325                 330                 335     


Leu Gly Pro Gly Ala Ser Leu Glu Glu Met Met Thr Ala Cys Gln Gly 
            340                 345                 350         


Val Gly Gly Pro Ser His Lys Ala Arg Ile Leu Ala Glu Ala Met Ser 
        355                 360                 365             


Gln Ala Asn Asn Thr Asn Ile Met Met Gln Arg Gly Asn Phe Lys Gly 
    370                 375                 380                 


Gln Lys Arg Ile Lys Cys Phe Asn Cys Gly Lys Glu Gly His Leu Ala 
385                 390                 395                 400 


Arg Asn Cys Arg Ala Pro Arg Lys Arg Gly Cys Trp Lys Cys Gly Arg 
                405                 410                 415     


Glu Gly His Gln Met Lys Asp Cys Asn Glu Arg Gln Ala Asn Phe Leu 
            420                 425                 430         


Gly Lys Ile Trp Pro Ser Ser Lys Gly Arg Pro Gly Asn Phe Pro Gln 
        435                 440                 445             


Ser Arg Pro Glu Pro Thr Ala Pro Leu Glu Pro Thr Ala Pro Pro Ala 
    450                 455                 460                 


Glu Pro Thr Ala Pro Pro Ala Glu Ser Phe Gly Phe Gly Glu Glu Ile 
465                 470                 475                 480 


Thr Pro Ser Pro Lys Gln Glu Gln Lys Asp Arg Glu Pro Leu Thr Ser 
                485                 490                 495     


Leu Lys Ser Leu Phe Gly Ser Asp Pro Leu Leu Gln Met Ala Pro Ile 
            500                 505                 510         


Ser Pro Ile Asp Thr Val Pro Val Thr Leu Lys Pro Gly Met Asp Gly 
        515                 520                 525             


Pro Lys Ile Lys Gln Trp Pro Leu Thr Glu Glu Lys Ile Lys Ala Leu 
    530                 535                 540                 


Thr Glu Ile Cys Thr Glu Met Glu Lys Glu Gly Lys Ile Ser Arg Ile 
545                 550                 555                 560 


Gly Pro Glu Asn Pro Tyr Asn Thr Pro Val Phe Ala Ile Lys Lys Lys 
                565                 570                 575     


Asn Ser Thr Arg Trp Arg Lys Leu Val Asp Phe Arg Glu Leu Asn Lys 
            580                 585                 590         


Lys Thr Gln Asp Phe Trp Glu Val Gln Leu Gly Ile Pro His Pro Ala 
        595                 600                 605             


Gly Leu Lys Lys Lys Arg Ser Val Thr Val Leu Ala Val Gly Asp Ala 
    610                 615                 620                 


Tyr Phe Ser Val Pro Leu Asp Lys Asp Phe Arg Lys Tyr Thr Ala Phe 
625                 630                 635                 640 


Thr Ile Pro Ser Val Asn Asn Glu Thr Pro Gly Val Arg Tyr Gln Tyr 
                645                 650                 655     


Asn Val Leu Pro Gln Gly Trp Lys Gly Ser Pro Ala Ile Phe Gln Cys 
            660                 665                 670         


Ser Met Thr Lys Ile Leu Glu Pro Phe Arg Ala Gln Asn Pro Glu Ile 
        675                 680                 685             


Val Ile Tyr Gln Tyr Val Ala Ala Leu Tyr Val Gly Ser Asp Leu Glu 
    690                 695                 700                 


Ile Glu Gln His Arg Thr Lys Ile Glu Glu Leu Arg Ala His Leu Leu 
705                 710                 715                 720 


Ser Trp Gly Phe Thr Thr Pro Asp Lys Lys His Gln Arg Glu Pro Pro 
                725                 730                 735     


Phe Leu Trp Met Gly Tyr Glu Leu His Pro Asp Arg Trp Thr Val Gln 
            740                 745                 750         


Pro Ile Glu Leu Pro Glu Lys Glu Ser Trp Thr Val Asn Asp Ile Gln 
        755                 760                 765             


Lys Leu Val Gly Lys Leu Asn Trp Ala Ser Gln Ile Tyr Pro Gly Ile 
    770                 775                 780                 


Lys Val Lys Gln Leu Cys Arg Leu Leu Arg Gly Ala Lys Ala Leu Thr 
785                 790                 795                 800 


Glu Val Ile Pro Leu Thr Lys Glu Ala Glu Leu Glu Leu Ala Glu Asn 
                805                 810                 815     


Arg Glu Ile Leu Arg Glu Pro Val His Gly Val Tyr Tyr Asp Pro Ser 
            820                 825                 830         


Lys Asp Leu Val Ala Glu Ile Gln Lys Gln Gly Gln Asp Gln Trp Thr 
        835                 840                 845             


Tyr Gln Ile Tyr Gln Glu Pro Tyr Lys Asn Leu Lys Thr Gly Lys Tyr 
    850                 855                 860                 


Ala Arg Lys Arg Ser Ala His Thr Asn Asp Val Arg Gln Leu Thr Glu 
865                 870                 875                 880 


Ala Val Gln Lys Ile Ala Leu Glu Ser Ile Val Ile Trp Gly Lys Ile 
                885                 890                 895     


Pro Lys Phe Arg Leu Pro Ile Gln Arg Glu Thr Trp Glu Thr Trp Trp 
            900                 905                 910         


Thr Glu Tyr Trp Gln Ala Thr Trp Ile Pro Asp Trp Glu Phe Val Asn 
        915                 920                 925             


Thr Pro Pro Leu Val Lys Leu Trp Tyr Gln Leu Glu Lys Glu Pro Ile 
    930                 935                 940                 


Ala Gly Ala Glu Thr Phe Tyr Val Ala Gly Ala Ser Asn Arg Glu Thr 
945                 950                 955                 960 


Lys Ile Gly Lys Ala Gly Tyr Val Thr Asp Lys Gly Arg Gln Lys Val 
                965                 970                 975     


Val Ser Leu Thr Glu Thr Thr Asn Gln Lys Ala Ala Leu Gln Ala Ile 
            980                 985                 990         


Gln Leu Ala Leu Gln Asp Ser Gly  Pro Glu Val Asn Ile  Val Thr Ala 
        995                 1000                 1005             


Ser Gln  Tyr Val Leu Gly Ile  Ile Gln Ala Gln Pro  Asp Arg Ser 
    1010                 1015                 1020             


Glu Ser  Glu Leu Val Asn Gln  Ile Ile Glu Glu Leu  Ile Lys Lys 
    1025                 1030                 1035             


Glu Lys  Val Tyr Leu Ser Trp  Val Pro Ala His Lys  Gly Ile Gly 
    1040                 1045                 1050             


Gly Asn  Glu Gln Val Asp Lys  Leu Val Ser Ala Gly  Ile Arg Lys 
    1055                 1060                 1065             


Ile Leu  Phe Leu Asp Gly Ile  Asp Lys Ala Gln Glu  Glu His Glu 
    1070                 1075                 1080             


Arg Tyr  His Ser Asn Trp Arg  Thr Met Ala Ser Asp  Phe Asn Leu 
    1085                 1090                 1095             


Pro Pro  Ile Val Ala Lys Glu  Ile Val Ala Asn Cys  Asp Lys Cys 
    1100                 1105                 1110             


Gln Leu  Lys Gly Glu Ala Met  His Gly Gln Val Asp  Cys Ser Pro 
    1115                 1120                 1125             


Gly Met  Trp Gln Leu Ala Cys  Thr His Leu Glu Gly  Lys Ile Ile 
    1130                 1135                 1140             


Ile Val  Ala Val His Val Ala  Ser Gly Tyr Met Glu  Ala Glu Val 
    1145                 1150                 1155             


Ile Pro  Ala Glu Thr Gly Gln  Glu Thr Ala Tyr Tyr  Ile Leu Lys 
    1160                 1165                 1170             


Leu Ala  Gly Arg Trp Pro Val  Lys Val Val His Thr  Ala Asn Gly 
    1175                 1180                 1185             


Ser Asn  Phe Thr Ser Thr Thr  Val Lys Ala Ala Cys  Trp Trp Ala 
    1190                 1195                 1200             


Asn Val  Thr Gln Glu Phe Gly  Ile Pro Tyr Asn Pro  Gln Ser Gln 
    1205                 1210                 1215             


Gly Val  Ile Ala Ser Met Asn  Lys Glu Leu Lys Lys  Ile Ile Gly 
    1220                 1225                 1230             


Gln Val  Arg Glu Gln Ala Glu  His Leu Lys Thr Ala  Val Gln Met 
    1235                 1240                 1245             


Ala Val  Leu Ile His Asn Phe  Lys Arg Arg Gly Gly  Ile Gly Gly 
    1250                 1255                 1260             


Tyr Ser  Ala Gly Glu Arg Ile  Val Asp Ile Ile Ala  Thr Asp Ile 
    1265                 1270                 1275             


Gln Thr  Arg Glu Leu Gln Lys  Gln Ile Ile Lys Ile  Gln Asn Phe 
    1280                 1285                 1290             


Arg Val  Tyr Phe Arg Asp Ser  Arg Asp Pro Val Trp  Lys Gly Pro 
    1295                 1300                 1305             


Ala Lys  Leu Leu Trp Lys Gly  Glu Gly Ala Val Val  Ile Gln Asp 
    1310                 1315                 1320             


Asn Ser  Glu Ile Lys Val Val  Pro Arg Arg Lys Val  Lys Ile Ile 
    1325                 1330                 1335             


Arg Asp  Tyr Gly Lys Gln Met  Ala Gly Asp Asp Cys  Val Ala Gly 
    1340                 1345                 1350             


Arg Gln  Asp Glu Asp Gln 
    1355                 


<210>  27
<211>  1497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mosaic gagpol1 v4)

<400>  27

Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Arg Leu Lys 
            20                  25                  30          


His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 
    50                  55                  60                  


Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 
65                  70                  75                  80  


Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Glu Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 
            100                 105                 110         


Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly Asn Ser Ser Gln Val 
        115                 120                 125             


Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 
    130                 135                 140                 


Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 
145                 150                 155                 160 


Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 
                165                 170                 175     


Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 
            180                 185                 190         


Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 
        195                 200                 205             


Ala Ala Glu Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala 
    210                 215                 220                 


Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 
225                 230                 235                 240 


Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 
                245                 250                 255     


Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 
            260                 265                 270         


Ile Val Arg Met Tyr Ser Pro Val Ser Ile Leu Asp Ile Arg Gln Gly 
        275                 280                 285             


Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 
    290                 295                 300                 


Arg Ala Glu Gln Ala Ser Gln Asp Val Lys Asn Trp Met Thr Glu Thr 
305                 310                 315                 320 


Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 
                325                 330                 335     


Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 
            340                 345                 350         


Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met Ser 
        355                 360                 365             


Gln Val Thr Asn Ser Ala Thr Ile Met Met Gln Arg Gly Asn Phe Arg 
    370                 375                 380                 


Asn Gln Arg Lys Thr Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His 
385                 390                 395                 400 


Ile Ala Lys Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys 
                405                 410                 415     


Gly Lys Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn 
            420                 425                 430         


Phe Leu Gly Lys Ile Trp Pro Ser Asn Lys Gly Arg Pro Gly Asn Phe 
        435                 440                 445             


Leu Gln Asn Arg Pro Glu Pro Thr Ala Pro Pro Glu Glu Ser Phe Arg 
    450                 455                 460                 


Phe Gly Glu Glu Thr Thr Thr Pro Ser Gln Lys Gln Glu Pro Ile Asp 
465                 470                 475                 480 


Lys Glu Met Tyr Pro Leu Ala Ser Leu Lys Ser Leu Phe Gly Asn Asp 
                485                 490                 495     


Pro Ser Ser Gln Arg Glu Asn Leu Ala Phe Gln Gln Gly Glu Ala Arg 
            500                 505                 510         


Glu Phe Pro Ser Glu Gln Thr Arg Ala Asn Ser Pro Thr Ser Arg Glu 
        515                 520                 525             


Leu Gln Val Arg Gly Asp Asn Pro His Ser Glu Ala Gly Ala Glu Arg 
    530                 535                 540                 


Gln Gly Thr Leu Asn Phe Pro Gln Ile Thr Leu Trp Gln Arg Pro Leu 
545                 550                 555                 560 


Val Ser Ile Lys Val Gly Gly Gln Ile Arg Glu Ala Leu Leu Ala Thr 
                565                 570                 575     


Gly Ala Asp Asp Thr Val Leu Glu Asp Ile Asn Leu Pro Gly Lys Trp 
            580                 585                 590         


Lys Pro Lys Met Ile Gly Gly Ile Gly Gly Phe Ile Lys Val Gly Gln 
        595                 600                 605             


Tyr Asp Gln Ile Leu Ile Glu Ile Cys Gly Lys Lys Ala Ile Gly Thr 
    610                 615                 620                 


Val Leu Val Gly Pro Thr Pro Val Asn Ile Ile Gly Arg Asn Met Leu 
625                 630                 635                 640 


Thr Gln Leu Gly Cys Thr Leu Asn Phe Pro Ile Ser Pro Ile Glu Thr 
                645                 650                 655     


Val Pro Val Lys Leu Lys Pro Gly Met Asp Gly Pro Arg Val Lys Gln 
            660                 665                 670         


Trp Pro Leu Thr Glu Glu Lys Ile Lys Ala Leu Thr Ala Ile Cys Glu 
        675                 680                 685             


Glu Met Glu Lys Glu Gly Lys Ile Thr Lys Ile Gly Pro Glu Asn Pro 
    690                 695                 700                 


Tyr Asn Thr Pro Val Phe Ala Ile Lys Lys Lys Asp Ser Thr Lys Trp 
705                 710                 715                 720 


Arg Lys Leu Val Asp Phe Arg Glu Leu Asn Lys Arg Thr Gln Asp Phe 
                725                 730                 735     


Trp Glu Val Gln Leu Gly Ile Pro His Pro Ala Gly Leu Lys Lys Lys 
            740                 745                 750         


Lys Ser Val Thr Val Leu Asp Val Gly Asp Ala Tyr Phe Ser Val Pro 
        755                 760                 765             


Leu Asp Glu Gly Phe Arg Lys Tyr Thr Ala Phe Thr Ile Pro Ser Thr 
    770                 775                 780                 


Asn Asn Glu Thr Pro Gly Ile Arg Tyr Gln Tyr Asn Val Leu Pro Gln 
785                 790                 795                 800 


Gly Trp Lys Gly Ser Pro Ala Ile Phe Gln Cys Ser Met Thr Arg Ile 
                805                 810                 815     


Leu Glu Pro Phe Arg Ala Lys Asn Pro Glu Ile Val Ile Tyr Gln Tyr 
            820                 825                 830         


Met Asp His Leu Tyr Val Gly Ser Asp Leu Glu Ile Gly Gln His Arg 
        835                 840                 845             


Ala Lys Ile Glu Glu Leu Arg Glu His Leu Leu Lys Trp Gly Phe Thr 
    850                 855                 860                 


Thr Pro Asp Lys Lys His Gln Lys Glu Pro Pro Phe Leu Trp Met Gly 
865                 870                 875                 880 


Tyr Glu Leu His Pro Asp Lys Trp Thr Val Gln Pro Ile Gln Leu Pro 
                885                 890                 895     


Glu Lys Asp Ser Trp Thr Val Asn Asp Ile Gln Lys Leu Val Gly Lys 
            900                 905                 910         


Leu Asn Trp Ala Ser Gln Ile Tyr Pro Gly Ile Lys Val Arg Gln Leu 
        915                 920                 925             


Cys Lys Leu Leu Arg Gly Ala Lys Ala Leu Thr Asp Ile Val Pro Leu 
    930                 935                 940                 


Thr Glu Glu Ala Glu Leu Glu Leu Ala Glu Asn Arg Glu Ile Leu Lys 
945                 950                 955                 960 


Glu Pro Val His Gly Val Tyr Tyr Asp Pro Ser Lys Asp Leu Ile Ala 
                965                 970                 975     


Glu Ile Gln Lys Gln Gly His Asp Gln Trp Thr Tyr Gln Ile Tyr Gln 
            980                 985                 990         


Glu Pro Phe Lys Asn Leu Lys Thr  Gly Lys Tyr Ala Lys  Met Arg Thr 
        995                 1000                 1005             


Ala His  Thr Asn Asp Val Lys  Gln Leu Thr Glu Ala  Val Gln Lys 
    1010                 1015                 1020             


Ile Ala  Met Glu Ser Ile Val  Ile Trp Gly Lys Thr  Pro Lys Phe 
    1025                 1030                 1035             


Arg Leu  Pro Ile Gln Lys Glu  Thr Trp Glu Thr Trp  Trp Thr Asp 
    1040                 1045                 1050             


Tyr Trp  Gln Ala Thr Trp Ile  Pro Glu Trp Glu Phe  Val Asn Thr 
    1055                 1060                 1065             


Pro Pro  Leu Val Lys Leu Trp  Tyr Gln Leu Glu Lys  Asp Pro Ile 
    1070                 1075                 1080             


Ala Gly  Val Glu Thr Phe Tyr  Val Asp Gly Ala Ala  Asn Arg Glu 
    1085                 1090                 1095             


Thr Lys  Leu Gly Lys Ala Gly  Tyr Val Thr Asp Arg  Gly Arg Gln 
    1100                 1105                 1110             


Lys Ile  Val Ser Leu Thr Glu  Thr Thr Asn Gln Lys  Thr Glu Leu 
    1115                 1120                 1125             


Gln Ala  Ile Tyr Leu Ala Leu  Gln Asp Ser Gly Ser  Glu Val Asn 
    1130                 1135                 1140             


Ile Val  Thr Asp Ser Gln Tyr  Ala Leu Gly Ile Ile  Gln Ala Gln 
    1145                 1150                 1155             


Pro Asp  Lys Ser Glu Ser Glu  Leu Val Asn Gln Ile  Ile Glu Gln 
    1160                 1165                 1170             


Leu Ile  Lys Lys Glu Arg Val  Tyr Leu Ser Trp Val  Pro Ala His 
    1175                 1180                 1185             


Lys Gly  Ile Gly Gly Asn Glu  Gln Val Asp Lys Leu  Val Ser Ser 
    1190                 1195                 1200             


Gly Ile  Arg Lys Val Leu Phe  Leu Asp Gly Ile Asp  Lys Ala Gln 
    1205                 1210                 1215             


Glu Glu  His Glu Lys Tyr His  Ser Asn Trp Arg Ala  Met Ala Ser 
    1220                 1225                 1230             


Asp Phe  Asn Leu Pro Pro Val  Val Ala Lys Glu Ile  Val Ala Ser 
    1235                 1240                 1245             


Cys Asp  Gln Cys Gln Leu Lys  Gly Glu Ala Met His  Gly Gln Val 
    1250                 1255                 1260             


Asp Cys  Ser Pro Gly Ile Trp  Gln Leu Ala Cys Thr  His Leu Glu 
    1265                 1270                 1275             


Gly Lys  Ile Ile Leu Val Ala  Val His Val Ala Ser  Gly Tyr Ile 
    1280                 1285                 1290             


Glu Ala  Glu Val Ile Pro Ala  Glu Thr Gly Gln Glu  Thr Ala Tyr 
    1295                 1300                 1305             


Phe Ile  Leu Lys Leu Ala Gly  Arg Trp Pro Val Lys  Val Ile His 
    1310                 1315                 1320             


Thr Asp  Asn Gly Ser Asn Phe  Thr Ser Ala Ala Val  Lys Ala Ala 
    1325                 1330                 1335             


Cys Trp  Trp Ala Gly Ile Gln  Gln Glu Phe Gly Ile  Pro Tyr Asn 
    1340                 1345                 1350             


Pro Gln  Ser Gln Gly Val Val  Glu Ser Met Asn Lys  Glu Leu Lys 
    1355                 1360                 1365             


Lys Ile  Ile Gly Gln Val Arg  Asp Gln Ala Glu His  Leu Lys Thr 
    1370                 1375                 1380             


Ala Val  Gln Met Ala Val Phe  Ile His Asn Phe Lys  Arg Lys Gly 
    1385                 1390                 1395             


Gly Ile  Gly Gly Tyr Ser Ala  Gly Glu Arg Ile Ile  Asp Ile Ile 
    1400                 1405                 1410             


Ala Thr  Asp Ile Gln Thr Lys  Glu Leu Gln Lys Gln  Ile Ile Lys 
    1415                 1420                 1425             


Ile Gln  Asn Phe Arg Val Tyr  Tyr Arg Asp Ser Arg  Asp Pro Ile 
    1430                 1435                 1440             


Trp Lys  Gly Pro Ala Lys Leu  Leu Trp Lys Gly Glu  Gly Ala Val 
    1445                 1450                 1455             


Val Ile  Gln Asp Asn Ser Asp  Ile Lys Val Val Pro  Arg Arg Lys 
    1460                 1465                 1470             


Val Lys  Ile Ile Lys Asp Tyr  Gly Lys Gln Met Ala  Gly Ala Asp 
    1475                 1480                 1485             


Cys Val  Ala Gly Arg Gln Asp  Glu Asp 
    1490                 1495         


<210>  28
<211>  1492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mosaic gagpol2 v4)

<400>  28

Met Gly Ala Arg Ala Ser Ile Leu Arg Gly Gly Lys Leu Asp Lys Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys His Tyr Met Leu Lys 
            20                  25                  30          


His Leu Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Leu Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Ser Glu Gly Cys Lys Gln Ile Ile Lys Gln Leu 
    50                  55                  60                  


Gln Pro Ala Leu Gln Thr Gly Thr Glu Glu Leu Arg Ser Leu Phe Asn 
65                  70                  75                  80  


Thr Val Ala Thr Leu Tyr Cys Val His Ala Glu Ile Glu Val Arg Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Gln 
            100                 105                 110         


Gln Lys Thr Gln Gln Ala Lys Glu Ala Asp Gly Lys Val Ser Gln Asn 
        115                 120                 125             


Tyr Pro Ile Val Gln Asn Leu Gln Gly Gln Met Val His Gln Pro Ile 
    130                 135                 140                 


Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Ile Glu Glu Lys Ala 
145                 150                 155                 160 


Phe Ser Pro Glu Val Ile Pro Met Phe Thr Ala Leu Ser Glu Gly Ala 
                165                 170                 175     


Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly Gly His Gln 
            180                 185                 190         


Ala Ala Met Gln Met Leu Lys Asp Thr Ile Asn Glu Glu Ala Ala Glu 
        195                 200                 205             


Trp Asp Arg Leu His Pro Val His Ala Gly Pro Val Ala Pro Gly Gln 
    210                 215                 220                 


Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr Ser Asn Leu 
225                 230                 235                 240 


Gln Glu Gln Ile Ala Trp Met Thr Ser Asn Pro Pro Ile Pro Val Gly 
                245                 250                 255     


Asp Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg 
            260                 265                 270         


Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Lys Gln Gly Pro Lys Glu 
        275                 280                 285             


Pro Phe Arg Asp Tyr Val Asp Arg Phe Phe Lys Thr Leu Arg Ala Glu 
    290                 295                 300                 


Gln Ala Thr Gln Asp Val Lys Asn Trp Met Thr Asp Thr Leu Leu Val 
305                 310                 315                 320 


Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Arg Ala Leu Gly Pro 
                325                 330                 335     


Gly Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly Val Gly Gly 
            340                 345                 350         


Pro Ser His Lys Ala Arg Val Leu Ala Glu Ala Met Ser Gln Thr Asn 
        355                 360                 365             


Ser Thr Ile Leu Met Gln Arg Ser Asn Phe Lys Gly Ser Lys Arg Ile 
    370                 375                 380                 


Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His Ile Ala Arg Asn Cys 
385                 390                 395                 400 


Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys Gly Lys Glu Gly His 
                405                 410                 415     


Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn Phe Leu Gly Lys Ile 
            420                 425                 430         


Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe Leu Gln Ser Arg Pro 
        435                 440                 445             


Glu Pro Thr Ala Pro Pro Ala Glu Ser Phe Arg Phe Glu Glu Thr Thr 
    450                 455                 460                 


Pro Ala Pro Lys Gln Glu Pro Lys Asp Arg Glu Pro Leu Thr Ser Leu 
465                 470                 475                 480 


Arg Ser Leu Phe Gly Ser Asp Pro Leu Ser Gln Arg Glu Asn Leu Ala 
                485                 490                 495     


Phe Pro Gln Gly Lys Ala Arg Glu Phe Ser Ser Glu Gln Thr Arg Ala 
            500                 505                 510         


Asn Ser Pro Thr Arg Arg Glu Leu Gln Val Trp Gly Arg Asp Asn Asn 
        515                 520                 525             


Ser Leu Ser Glu Ala Gly Ala Asp Arg Gln Gly Thr Val Ser Phe Ser 
    530                 535                 540                 


Phe Pro Gln Ile Thr Leu Trp Gln Arg Pro Leu Val Thr Ile Lys Ile 
545                 550                 555                 560 


Gly Gly Gln Leu Lys Glu Ala Leu Leu Ala Thr Gly Ala Asp Asp Thr 
                565                 570                 575     


Val Leu Glu Glu Met Asn Leu Pro Gly Arg Trp Lys Pro Lys Met Ile 
            580                 585                 590         


Gly Gly Ile Gly Gly Phe Ile Lys Val Gly Gln Tyr Asp Gln Ile Pro 
        595                 600                 605             


Ile Glu Ile Cys Gly His Lys Ala Ile Gly Thr Val Leu Val Gly Pro 
    610                 615                 620                 


Thr Pro Val Asn Ile Ile Gly Arg Asn Leu Leu Thr Gln Ile Gly Cys 
625                 630                 635                 640 


Thr Leu Asn Phe Pro Ile Ser Pro Ile Glu Thr Val Pro Val Lys Leu 
                645                 650                 655     


Lys Pro Gly Met Asp Gly Pro Lys Val Lys Gln Trp Pro Leu Thr Glu 
            660                 665                 670         


Glu Lys Ile Lys Ala Leu Val Glu Ile Cys Thr Glu Met Glu Lys Glu 
        675                 680                 685             


Gly Lys Ile Ser Lys Ile Gly Pro Glu Asn Pro Tyr Asn Thr Pro Ile 
    690                 695                 700                 


Phe Ala Ile Lys Lys Lys Asp Ser Thr Lys Trp Arg Lys Leu Val Asp 
705                 710                 715                 720 


Phe Arg Glu Leu Asn Lys Arg Thr Gln Asp Phe Trp Glu Val Gln Leu 
                725                 730                 735     


Gly Ile Pro His Pro Ala Gly Leu Lys Lys Lys Lys Ser Val Thr Val 
            740                 745                 750         


Leu Asp Val Gly Asp Ala Tyr Phe Ser Val Pro Leu Asp Glu Asp Phe 
        755                 760                 765             


Arg Lys Tyr Thr Ala Phe Thr Ile Pro Ser Ile Asn Asn Glu Thr Pro 
    770                 775                 780                 


Gly Ile Arg Tyr Gln Tyr Asn Val Leu Pro Gln Gly Trp Lys Gly Ser 
785                 790                 795                 800 


Pro Ala Ile Phe Gln Ser Ser Met Thr Lys Ile Leu Glu Pro Phe Arg 
                805                 810                 815     


Lys Gln Asn Pro Asp Ile Val Ile Tyr Gln Tyr Met Asp His Leu Tyr 
            820                 825                 830         


Val Gly Ser Asp Leu Glu Ile Gly Gln His Arg Thr Lys Ile Glu Glu 
        835                 840                 845             


Leu Arg Gln His Leu Leu Arg Trp Gly Phe Thr Thr Pro Asp Lys Lys 
    850                 855                 860                 


His Gln Lys Glu Pro Pro Phe Leu Trp Met Gly Tyr Glu Leu His Pro 
865                 870                 875                 880 


Asp Lys Trp Thr Val Gln Pro Ile Val Leu Pro Glu Lys Asp Ser Trp 
                885                 890                 895     


Thr Val Asn Asp Ile Gln Lys Leu Val Gly Lys Leu Asn Trp Ala Ser 
            900                 905                 910         


Gln Ile Tyr Ala Gly Ile Lys Val Lys Gln Leu Cys Lys Leu Leu Arg 
        915                 920                 925             


Gly Thr Lys Ala Leu Thr Glu Val Val Pro Leu Thr Glu Glu Ala Glu 
    930                 935                 940                 


Leu Glu Leu Ala Glu Asn Arg Glu Ile Leu Lys Glu Pro Val His Gly 
945                 950                 955                 960 


Val Tyr Tyr Asp Pro Ser Lys Asp Leu Ile Ala Glu Ile Gln Lys Gln 
                965                 970                 975     


Gly Gln Gly Gln Trp Thr Tyr Gln Ile Tyr Gln Glu Pro Phe Lys Asn 
            980                 985                 990         


Leu Lys Thr Gly Lys Tyr Ala Arg  Met Arg Gly Ala His  Thr Asn Asp 
        995                 1000                 1005             


Val Lys  Gln Leu Thr Glu Ala  Val Gln Lys Ile Ala  Thr Glu Ser 
    1010                 1015                 1020             


Ile Val  Ile Trp Gly Lys Thr  Pro Lys Phe Lys Leu  Pro Ile Gln 
    1025                 1030                 1035             


Lys Glu  Thr Trp Glu Ala Trp  Trp Thr Glu Tyr Trp  Gln Ala Thr 
    1040                 1045                 1050             


Trp Ile  Pro Glu Trp Glu Phe  Val Asn Thr Pro Pro  Leu Val Lys 
    1055                 1060                 1065             


Leu Trp  Tyr Gln Leu Glu Lys  Glu Pro Ile Val Gly  Ala Glu Thr 
    1070                 1075                 1080             


Phe Tyr  Val Asp Gly Ala Ala  Asn Arg Glu Thr Lys  Leu Gly Lys 
    1085                 1090                 1095             


Ala Gly  Tyr Val Thr Asp Arg  Gly Arg Gln Lys Val  Val Ser Leu 
    1100                 1105                 1110             


Thr Asp  Thr Thr Asn Gln Lys  Thr Glu Leu Gln Ala  Ile His Leu 
    1115                 1120                 1125             


Ala Leu  Gln Asp Ser Gly Leu  Glu Val Asn Ile Val  Thr Asp Ser 
    1130                 1135                 1140             


Gln Tyr  Ala Leu Gly Ile Ile  Gln Ala Gln Pro Asp  Lys Ser Glu 
    1145                 1150                 1155             


Ser Glu  Leu Val Ser Gln Ile  Ile Glu Gln Leu Ile  Lys Lys Glu 
    1160                 1165                 1170             


Lys Val  Tyr Leu Ala Trp Val  Pro Ala His Lys Gly  Ile Gly Gly 
    1175                 1180                 1185             


Asn Glu  Gln Val Asp Lys Leu  Val Ser Arg Gly Ile  Arg Lys Val 
    1190                 1195                 1200             


Leu Phe  Leu Asp Gly Ile Asp  Lys Ala Gln Glu Glu  His Glu Lys 
    1205                 1210                 1215             


Tyr His  Ser Asn Trp Arg Ala  Met Ala Ser Glu Phe  Asn Leu Pro 
    1220                 1225                 1230             


Pro Ile  Val Ala Lys Glu Ile  Val Ala Ser Cys Asp  Lys Cys Gln 
    1235                 1240                 1245             


Leu Lys  Gly Glu Ala Ile His  Gly Gln Val Asp Cys  Ser Pro Gly 
    1250                 1255                 1260             


Ile Trp  Gln Leu Ala Cys Thr  His Leu Glu Gly Lys  Val Ile Leu 
    1265                 1270                 1275             


Val Ala  Val His Val Ala Ser  Gly Tyr Ile Glu Ala  Glu Val Ile 
    1280                 1285                 1290             


Pro Ala  Glu Thr Gly Gln Glu  Thr Ala Tyr Phe Leu  Leu Lys Leu 
    1295                 1300                 1305             


Ala Gly  Arg Trp Pro Val Lys  Thr Ile His Thr Asp  Asn Gly Ser 
    1310                 1315                 1320             


Asn Phe  Thr Ser Ala Thr Val  Lys Ala Ala Cys Trp  Trp Ala Gly 
    1325                 1330                 1335             


Ile Lys  Gln Glu Phe Gly Ile  Pro Tyr Asn Pro Gln  Ser Gln Gly 
    1340                 1345                 1350             


Val Val  Glu Ser Ile Asn Lys  Glu Leu Lys Lys Ile  Ile Gly Gln 
    1355                 1360                 1365             


Val Arg  Asp Gln Ala Glu His  Leu Lys Thr Ala Val  Gln Met Ala 
    1370                 1375                 1380             


Val Phe  Ile His Asn Phe Lys  Arg Lys Gly Gly Ile  Gly Glu Tyr 
    1385                 1390                 1395             


Ser Ala  Gly Glu Arg Ile Val  Asp Ile Ile Ala Ser  Asp Ile Gln 
    1400                 1405                 1410             


Thr Lys  Glu Leu Gln Lys Gln  Ile Thr Lys Ile Gln  Asn Phe Arg 
    1415                 1420                 1425             


Val Tyr  Tyr Arg Asp Ser Arg  Asp Pro Leu Trp Lys  Gly Pro Ala 
    1430                 1435                 1440             


Lys Leu  Leu Trp Lys Gly Glu  Gly Ala Val Val Ile  Gln Asp Asn 
    1445                 1450                 1455             


Ser Asp  Ile Lys Val Val Pro  Arg Arg Lys Ala Lys  Ile Ile Arg 
    1460                 1465                 1470             


Asp Tyr  Gly Lys Gln Met Ala  Gly Asp Asp Cys Val  Ala Ser Arg 
    1475                 1480                 1485             


Gln Asp  Glu Asp 
    1490         


<210>  29
<211>  1350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mosaic gagpol1 v5)

<400>  29

Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Arg Leu Lys 
            20                  25                  30          


His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 
    50                  55                  60                  


Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 
65                  70                  75                  80  


Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Glu Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 
            100                 105                 110         


Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly Asn Ser Ser Gln Val 
        115                 120                 125             


Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 
    130                 135                 140                 


Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 
145                 150                 155                 160 


Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 
                165                 170                 175     


Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 
            180                 185                 190         


Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 
        195                 200                 205             


Ala Ala Glu Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala 
    210                 215                 220                 


Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 
225                 230                 235                 240 


Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 
                245                 250                 255     


Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 
            260                 265                 270         


Ile Val Arg Met Tyr Ser Pro Val Ser Ile Leu Asp Ile Arg Gln Gly 
        275                 280                 285             


Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 
    290                 295                 300                 


Arg Ala Glu Gln Ala Ser Gln Asp Val Lys Asn Trp Met Thr Glu Thr 
305                 310                 315                 320 


Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 
                325                 330                 335     


Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 
            340                 345                 350         


Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met Ser 
        355                 360                 365             


Gln Val Thr Asn Ser Ala Thr Ile Met Met Gln Arg Gly Asn Phe Arg 
    370                 375                 380                 


Asn Gln Arg Lys Thr Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His 
385                 390                 395                 400 


Ile Ala Lys Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys 
                405                 410                 415     


Gly Lys Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn 
            420                 425                 430         


Phe Leu Gly Lys Ile Trp Pro Ser Asn Lys Gly Arg Pro Gly Asn Phe 
        435                 440                 445             


Leu Gln Asn Arg Pro Glu Pro Thr Ala Pro Pro Glu Glu Ser Phe Arg 
    450                 455                 460                 


Phe Gly Glu Glu Thr Thr Thr Pro Ser Gln Lys Gln Glu Pro Ile Asp 
465                 470                 475                 480 


Lys Glu Met Tyr Pro Leu Ala Ser Leu Lys Ser Leu Phe Gly Asn Asp 
                485                 490                 495     


Pro Ser Ser Gln Met Ala Pro Ile Ser Pro Ile Glu Thr Val Pro Val 
            500                 505                 510         


Lys Leu Lys Pro Gly Met Asp Gly Pro Arg Val Lys Gln Trp Pro Leu 
        515                 520                 525             


Thr Glu Glu Lys Ile Lys Ala Leu Thr Ala Ile Cys Glu Glu Met Glu 
    530                 535                 540                 


Lys Glu Gly Lys Ile Thr Lys Ile Gly Pro Glu Asn Pro Tyr Asn Thr 
545                 550                 555                 560 


Pro Val Phe Ala Ile Lys Lys Lys Asp Ser Thr Lys Trp Arg Lys Leu 
                565                 570                 575     


Val Asp Phe Arg Glu Leu Asn Lys Arg Thr Gln Asp Phe Trp Glu Val 
            580                 585                 590         


Gln Leu Gly Ile Pro His Pro Ala Gly Leu Lys Lys Lys Lys Ser Val 
        595                 600                 605             


Thr Val Leu Asp Val Gly Asp Ala Tyr Phe Ser Val Pro Leu Asp Glu 
    610                 615                 620                 


Gly Phe Arg Lys Tyr Thr Ala Phe Thr Ile Pro Ser Thr Asn Asn Glu 
625                 630                 635                 640 


Thr Pro Gly Ile Arg Tyr Gln Tyr Asn Val Leu Pro Gln Gly Trp Lys 
                645                 650                 655     


Gly Ser Pro Ala Ile Phe Gln Cys Ser Met Thr Arg Ile Leu Glu Pro 
            660                 665                 670         


Phe Arg Ala Lys Asn Pro Glu Ile Val Ile Tyr Gln Tyr Met Asp His 
        675                 680                 685             


Leu Tyr Val Gly Ser Asp Leu Glu Ile Gly Gln His Arg Ala Lys Ile 
    690                 695                 700                 


Glu Glu Leu Arg Glu His Leu Leu Lys Trp Gly Phe Thr Thr Pro Asp 
705                 710                 715                 720 


Lys Lys His Gln Lys Glu Pro Pro Phe Leu Trp Met Gly Tyr Glu Leu 
                725                 730                 735     


His Pro Asp Lys Trp Thr Val Gln Pro Ile Gln Leu Pro Glu Lys Asp 
            740                 745                 750         


Ser Trp Thr Val Asn Asp Ile Gln Lys Leu Val Gly Lys Leu Asn Trp 
        755                 760                 765             


Ala Ser Gln Ile Tyr Pro Gly Ile Lys Val Arg Gln Leu Cys Lys Leu 
    770                 775                 780                 


Leu Arg Gly Ala Lys Ala Leu Thr Asp Ile Val Pro Leu Thr Glu Glu 
785                 790                 795                 800 


Ala Glu Leu Glu Leu Ala Glu Asn Arg Glu Ile Leu Lys Glu Pro Val 
                805                 810                 815     


His Gly Val Tyr Tyr Asp Pro Ser Lys Asp Leu Ile Ala Glu Ile Gln 
            820                 825                 830         


Lys Gln Gly His Asp Gln Trp Thr Tyr Gln Ile Tyr Gln Glu Pro Phe 
        835                 840                 845             


Lys Asn Leu Lys Thr Gly Lys Tyr Ala Lys Met Arg Thr Ala His Thr 
    850                 855                 860                 


Asn Asp Val Lys Gln Leu Thr Glu Ala Val Gln Lys Ile Ala Met Glu 
865                 870                 875                 880 


Ser Ile Val Ile Trp Gly Lys Thr Pro Lys Phe Arg Leu Pro Ile Gln 
                885                 890                 895     


Lys Glu Thr Trp Glu Thr Trp Trp Thr Asp Tyr Trp Gln Ala Thr Trp 
            900                 905                 910         


Ile Pro Glu Trp Glu Phe Val Asn Thr Pro Pro Leu Val Lys Leu Trp 
        915                 920                 925             


Tyr Gln Leu Glu Lys Asp Pro Ile Ala Gly Val Glu Thr Phe Tyr Val 
    930                 935                 940                 


Asp Gly Ala Ala Asn Arg Glu Thr Lys Leu Gly Lys Ala Gly Tyr Val 
945                 950                 955                 960 


Thr Asp Arg Gly Arg Gln Lys Ile Val Ser Leu Thr Glu Thr Thr Asn 
                965                 970                 975     


Gln Lys Thr Glu Leu Gln Ala Ile Tyr Leu Ala Leu Gln Asp Ser Gly 
            980                 985                 990         


Ser Glu Val Asn Ile Val Thr Asp  Ser Gln Tyr Ala Leu  Gly Ile Ile 
        995                 1000                 1005             


Gln Ala  Gln Pro Asp Lys Ser  Glu Ser Glu Leu Val  Asn Gln Ile 
    1010                 1015                 1020             


Ile Glu  Gln Leu Ile Lys Lys  Glu Arg Val Tyr Leu  Ser Trp Val 
    1025                 1030                 1035             


Pro Ala  His Lys Gly Ile Gly  Gly Asn Glu Gln Val  Asp Lys Leu 
    1040                 1045                 1050             


Val Ser  Ser Gly Ile Arg Lys  Val Leu Phe Leu Asp  Gly Ile Asp 
    1055                 1060                 1065             


Lys Ala  Gln Glu Glu His Glu  Lys Tyr His Ser Asn  Trp Arg Ala 
    1070                 1075                 1080             


Met Ala  Ser Asp Phe Asn Leu  Pro Pro Val Val Ala  Lys Glu Ile 
    1085                 1090                 1095             


Val Ala  Ser Cys Asp Gln Cys  Gln Leu Lys Gly Glu  Ala Met His 
    1100                 1105                 1110             


Gly Gln  Val Asp Cys Ser Pro  Gly Ile Trp Gln Leu  Ala Cys Thr 
    1115                 1120                 1125             


His Leu  Glu Gly Lys Ile Ile  Leu Val Ala Val His  Val Ala Ser 
    1130                 1135                 1140             


Gly Tyr  Ile Glu Ala Glu Val  Ile Pro Ala Glu Thr  Gly Gln Glu 
    1145                 1150                 1155             


Thr Ala  Tyr Phe Ile Leu Lys  Leu Ala Gly Arg Trp  Pro Val Lys 
    1160                 1165                 1170             


Val Ile  His Thr Asp Asn Gly  Ser Asn Phe Thr Ser  Ala Ala Val 
    1175                 1180                 1185             


Lys Ala  Ala Cys Trp Trp Ala  Gly Ile Gln Gln Glu  Phe Gly Ile 
    1190                 1195                 1200             


Pro Tyr  Asn Pro Gln Ser Gln  Gly Val Val Glu Ser  Met Asn Lys 
    1205                 1210                 1215             


Glu Leu  Lys Lys Ile Ile Gly  Gln Val Arg Asp Gln  Ala Glu His 
    1220                 1225                 1230             


Leu Lys  Thr Ala Val Gln Met  Ala Val Phe Ile His  Asn Phe Lys 
    1235                 1240                 1245             


Arg Lys  Gly Gly Ile Gly Gly  Tyr Ser Ala Gly Glu  Arg Ile Ile 
    1250                 1255                 1260             


Asp Ile  Ile Ala Thr Asp Ile  Gln Thr Lys Glu Leu  Gln Lys Gln 
    1265                 1270                 1275             


Ile Ile  Lys Ile Gln Asn Phe  Arg Val Tyr Tyr Arg  Asp Ser Arg 
    1280                 1285                 1290             


Asp Pro  Ile Trp Lys Gly Pro  Ala Lys Leu Leu Trp  Lys Gly Glu 
    1295                 1300                 1305             


Gly Ala  Val Val Ile Gln Asp  Asn Ser Asp Ile Lys  Val Val Pro 
    1310                 1315                 1320             


Arg Arg  Lys Val Lys Ile Ile  Lys Asp Tyr Gly Lys  Gln Met Ala 
    1325                 1330                 1335             


Gly Ala  Asp Cys Val Ala Gly  Arg Gln Asp Glu Asp  
    1340                 1345                 1350 


<210>  30
<211>  1341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mosaic gagpol2 v5)

<400>  30

Met Gly Ala Arg Ala Ser Ile Leu Arg Gly Gly Lys Leu Asp Lys Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys His Tyr Met Leu Lys 
            20                  25                  30          


His Leu Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Leu Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Ser Glu Gly Cys Lys Gln Ile Ile Lys Gln Leu 
    50                  55                  60                  


Gln Pro Ala Leu Gln Thr Gly Thr Glu Glu Leu Arg Ser Leu Phe Asn 
65                  70                  75                  80  


Thr Val Ala Thr Leu Tyr Cys Val His Ala Glu Ile Glu Val Arg Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Gln 
            100                 105                 110         


Gln Lys Thr Gln Gln Ala Lys Glu Ala Asp Gly Lys Val Ser Gln Asn 
        115                 120                 125             


Tyr Pro Ile Val Gln Asn Leu Gln Gly Gln Met Val His Gln Pro Ile 
    130                 135                 140                 


Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Ile Glu Glu Lys Ala 
145                 150                 155                 160 


Phe Ser Pro Glu Val Ile Pro Met Phe Thr Ala Leu Ser Glu Gly Ala 
                165                 170                 175     


Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly Gly His Gln 
            180                 185                 190         


Ala Ala Met Gln Met Leu Lys Asp Thr Ile Asn Glu Glu Ala Ala Glu 
        195                 200                 205             


Trp Asp Arg Leu His Pro Val His Ala Gly Pro Val Ala Pro Gly Gln 
    210                 215                 220                 


Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr Ser Asn Leu 
225                 230                 235                 240 


Gln Glu Gln Ile Ala Trp Met Thr Ser Asn Pro Pro Ile Pro Val Gly 
                245                 250                 255     


Asp Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg 
            260                 265                 270         


Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Lys Gln Gly Pro Lys Glu 
        275                 280                 285             


Pro Phe Arg Asp Tyr Val Asp Arg Phe Phe Lys Thr Leu Arg Ala Glu 
    290                 295                 300                 


Gln Ala Thr Gln Asp Val Lys Asn Trp Met Thr Asp Thr Leu Leu Val 
305                 310                 315                 320 


Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Arg Ala Leu Gly Pro 
                325                 330                 335     


Gly Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly Val Gly Gly 
            340                 345                 350         


Pro Ser His Lys Ala Arg Val Leu Ala Glu Ala Met Ser Gln Thr Asn 
        355                 360                 365             


Ser Thr Ile Leu Met Gln Arg Ser Asn Phe Lys Gly Ser Lys Arg Ile 
    370                 375                 380                 


Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His Ile Ala Arg Asn Cys 
385                 390                 395                 400 


Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys Gly Lys Glu Gly His 
                405                 410                 415     


Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn Phe Leu Gly Lys Ile 
            420                 425                 430         


Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe Leu Gln Ser Arg Pro 
        435                 440                 445             


Glu Pro Thr Ala Pro Pro Ala Glu Ser Phe Arg Phe Glu Glu Thr Thr 
    450                 455                 460                 


Pro Ala Pro Lys Gln Glu Pro Lys Asp Arg Glu Pro Leu Thr Ser Leu 
465                 470                 475                 480 


Arg Ser Leu Phe Gly Ser Asp Pro Leu Ser Gln Met Ala Pro Ile Ser 
                485                 490                 495     


Pro Ile Glu Thr Val Pro Val Lys Leu Lys Pro Gly Met Asp Gly Pro 
            500                 505                 510         


Lys Val Lys Gln Trp Pro Leu Thr Glu Glu Lys Ile Lys Ala Leu Val 
        515                 520                 525             


Glu Ile Cys Thr Glu Met Glu Lys Glu Gly Lys Ile Ser Lys Ile Gly 
    530                 535                 540                 


Pro Glu Asn Pro Tyr Asn Thr Pro Ile Phe Ala Ile Lys Lys Lys Asp 
545                 550                 555                 560 


Ser Thr Lys Trp Arg Lys Leu Val Asp Phe Arg Glu Leu Asn Lys Arg 
                565                 570                 575     


Thr Gln Asp Phe Trp Glu Val Gln Leu Gly Ile Pro His Pro Ala Gly 
            580                 585                 590         


Leu Lys Lys Lys Lys Ser Val Thr Val Leu Asp Val Gly Asp Ala Tyr 
        595                 600                 605             


Phe Ser Val Pro Leu Asp Glu Asp Phe Arg Lys Tyr Thr Ala Phe Thr 
    610                 615                 620                 


Ile Pro Ser Ile Asn Asn Glu Thr Pro Gly Ile Arg Tyr Gln Tyr Asn 
625                 630                 635                 640 


Val Leu Pro Gln Gly Trp Lys Gly Ser Pro Ala Ile Phe Gln Ser Ser 
                645                 650                 655     


Met Thr Lys Ile Leu Glu Pro Phe Arg Lys Gln Asn Pro Asp Ile Val 
            660                 665                 670         


Ile Tyr Gln Tyr Met Asp His Leu Tyr Val Gly Ser Asp Leu Glu Ile 
        675                 680                 685             


Gly Gln His Arg Thr Lys Ile Glu Glu Leu Arg Gln His Leu Leu Arg 
    690                 695                 700                 


Trp Gly Phe Thr Thr Pro Asp Lys Lys His Gln Lys Glu Pro Pro Phe 
705                 710                 715                 720 


Leu Trp Met Gly Tyr Glu Leu His Pro Asp Lys Trp Thr Val Gln Pro 
                725                 730                 735     


Ile Val Leu Pro Glu Lys Asp Ser Trp Thr Val Asn Asp Ile Gln Lys 
            740                 745                 750         


Leu Val Gly Lys Leu Asn Trp Ala Ser Gln Ile Tyr Ala Gly Ile Lys 
        755                 760                 765             


Val Lys Gln Leu Cys Lys Leu Leu Arg Gly Thr Lys Ala Leu Thr Glu 
    770                 775                 780                 


Val Val Pro Leu Thr Glu Glu Ala Glu Leu Glu Leu Ala Glu Asn Arg 
785                 790                 795                 800 


Glu Ile Leu Lys Glu Pro Val His Gly Val Tyr Tyr Asp Pro Ser Lys 
                805                 810                 815     


Asp Leu Ile Ala Glu Ile Gln Lys Gln Gly Gln Gly Gln Trp Thr Tyr 
            820                 825                 830         


Gln Ile Tyr Gln Glu Pro Phe Lys Asn Leu Lys Thr Gly Lys Tyr Ala 
        835                 840                 845             


Arg Met Arg Gly Ala His Thr Asn Asp Val Lys Gln Leu Thr Glu Ala 
    850                 855                 860                 


Val Gln Lys Ile Ala Thr Glu Ser Ile Val Ile Trp Gly Lys Thr Pro 
865                 870                 875                 880 


Lys Phe Lys Leu Pro Ile Gln Lys Glu Thr Trp Glu Ala Trp Trp Thr 
                885                 890                 895     


Glu Tyr Trp Gln Ala Thr Trp Ile Pro Glu Trp Glu Phe Val Asn Thr 
            900                 905                 910         


Pro Pro Leu Val Lys Leu Trp Tyr Gln Leu Glu Lys Glu Pro Ile Val 
        915                 920                 925             


Gly Ala Glu Thr Phe Tyr Val Asp Gly Ala Ala Asn Arg Glu Thr Lys 
    930                 935                 940                 


Leu Gly Lys Ala Gly Tyr Val Thr Asp Arg Gly Arg Gln Lys Val Val 
945                 950                 955                 960 


Ser Leu Thr Asp Thr Thr Asn Gln Lys Thr Glu Leu Gln Ala Ile His 
                965                 970                 975     


Leu Ala Leu Gln Asp Ser Gly Leu Glu Val Asn Ile Val Thr Asp Ser 
            980                 985                 990         


Gln Tyr Ala Leu Gly Ile Ile Gln  Ala Gln Pro Asp Lys  Ser Glu Ser 
        995                 1000                 1005             


Glu Leu  Val Ser Gln Ile Ile  Glu Gln Leu Ile Lys  Lys Glu Lys 
    1010                 1015                 1020             


Val Tyr  Leu Ala Trp Val Pro  Ala His Lys Gly Ile  Gly Gly Asn 
    1025                 1030                 1035             


Glu Gln  Val Asp Lys Leu Val  Ser Arg Gly Ile Arg  Lys Val Leu 
    1040                 1045                 1050             


Phe Leu  Asp Gly Ile Asp Lys  Ala Gln Glu Glu His  Glu Lys Tyr 
    1055                 1060                 1065             


His Ser  Asn Trp Arg Ala Met  Ala Ser Glu Phe Asn  Leu Pro Pro 
    1070                 1075                 1080             


Ile Val  Ala Lys Glu Ile Val  Ala Ser Cys Asp Lys  Cys Gln Leu 
    1085                 1090                 1095             


Lys Gly  Glu Ala Ile His Gly  Gln Val Asp Cys Ser  Pro Gly Ile 
    1100                 1105                 1110             


Trp Gln  Leu Ala Cys Thr His  Leu Glu Gly Lys Val  Ile Leu Val 
    1115                 1120                 1125             


Ala Val  His Val Ala Ser Gly  Tyr Ile Glu Ala Glu  Val Ile Pro 
    1130                 1135                 1140             


Ala Glu  Thr Gly Gln Glu Thr  Ala Tyr Phe Leu Leu  Lys Leu Ala 
    1145                 1150                 1155             


Gly Arg  Trp Pro Val Lys Thr  Ile His Thr Asp Asn  Gly Ser Asn 
    1160                 1165                 1170             


Phe Thr  Ser Ala Thr Val Lys  Ala Ala Cys Trp Trp  Ala Gly Ile 
    1175                 1180                 1185             


Lys Gln  Glu Phe Gly Ile Pro  Tyr Asn Pro Gln Ser  Gln Gly Val 
    1190                 1195                 1200             


Val Glu  Ser Ile Asn Lys Glu  Leu Lys Lys Ile Ile  Gly Gln Val 
    1205                 1210                 1215             


Arg Asp  Gln Ala Glu His Leu  Lys Thr Ala Val Gln  Met Ala Val 
    1220                 1225                 1230             


Phe Ile  His Asn Phe Lys Arg  Lys Gly Gly Ile Gly  Glu Tyr Ser 
    1235                 1240                 1245             


Ala Gly  Glu Arg Ile Val Asp  Ile Ile Ala Ser Asp  Ile Gln Thr 
    1250                 1255                 1260             


Lys Glu  Leu Gln Lys Gln Ile  Thr Lys Ile Gln Asn  Phe Arg Val 
    1265                 1270                 1275             


Tyr Tyr  Arg Asp Ser Arg Asp  Pro Leu Trp Lys Gly  Pro Ala Lys 
    1280                 1285                 1290             


Leu Leu  Trp Lys Gly Glu Gly  Ala Val Val Ile Gln  Asp Asn Ser 
    1295                 1300                 1305             


Asp Ile  Lys Val Val Pro Arg  Arg Lys Ala Lys Ile  Ile Arg Asp 
    1310                 1315                 1320             


Tyr Gly  Lys Gln Met Ala Gly  Asp Asp Cys Val Ala  Ser Arg Gln 
    1325                 1330                 1335             


Asp Glu  Asp 
    1340     


<210>  31
<211>  1556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mosaic gagpolnef1)

<400>  31

Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Arg Leu Lys 
            20                  25                  30          


His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 
    50                  55                  60                  


Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 
65                  70                  75                  80  


Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Glu Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 
            100                 105                 110         


Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly Asn Ser Ser Gln Val 
        115                 120                 125             


Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 
    130                 135                 140                 


Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 
145                 150                 155                 160 


Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 
                165                 170                 175     


Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 
            180                 185                 190         


Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 
        195                 200                 205             


Ala Ala Glu Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala 
    210                 215                 220                 


Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 
225                 230                 235                 240 


Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 
                245                 250                 255     


Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 
            260                 265                 270         


Ile Val Arg Met Tyr Ser Pro Val Ser Ile Leu Asp Ile Arg Gln Gly 
        275                 280                 285             


Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 
    290                 295                 300                 


Arg Ala Glu Gln Ala Ser Gln Asp Val Lys Asn Trp Met Thr Glu Thr 
305                 310                 315                 320 


Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 
                325                 330                 335     


Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 
            340                 345                 350         


Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met Ser 
        355                 360                 365             


Gln Val Thr Asn Ser Ala Thr Ile Met Met Gln Arg Gly Asn Phe Arg 
    370                 375                 380                 


Asn Gln Arg Lys Thr Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His 
385                 390                 395                 400 


Ile Ala Lys Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys 
                405                 410                 415     


Gly Lys Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn 
            420                 425                 430         


Phe Leu Gly Lys Ile Trp Pro Ser Asn Lys Gly Arg Pro Gly Asn Phe 
        435                 440                 445             


Leu Gln Asn Arg Pro Glu Pro Thr Ala Pro Pro Glu Glu Ser Phe Arg 
    450                 455                 460                 


Phe Gly Glu Glu Thr Thr Thr Pro Ser Gln Lys Gln Glu Pro Ile Asp 
465                 470                 475                 480 


Lys Glu Met Tyr Pro Leu Ala Ser Leu Lys Ser Leu Phe Gly Asn Asp 
                485                 490                 495     


Pro Ser Ser Gln Met Ala Pro Ile Ser Pro Ile Glu Thr Val Pro Val 
            500                 505                 510         


Lys Leu Lys Pro Gly Met Asp Gly Pro Arg Val Lys Gln Trp Pro Leu 
        515                 520                 525             


Thr Glu Glu Lys Ile Lys Ala Leu Thr Ala Ile Cys Glu Glu Met Glu 
    530                 535                 540                 


Lys Glu Gly Lys Ile Thr Lys Ile Gly Pro Glu Asn Pro Tyr Asn Thr 
545                 550                 555                 560 


Pro Val Phe Ala Ile Lys Lys Lys Asp Ser Thr Lys Trp Arg Lys Leu 
                565                 570                 575     


Val Asp Phe Arg Glu Leu Asn Lys Arg Thr Gln Asp Phe Trp Glu Val 
            580                 585                 590         


Gln Leu Gly Ile Pro His Pro Ala Gly Leu Lys Lys Lys Lys Ser Val 
        595                 600                 605             


Thr Val Leu Ala Val Gly Asp Ala Tyr Phe Ser Val Pro Leu Asp Glu 
    610                 615                 620                 


Gly Phe Arg Lys Tyr Thr Ala Phe Thr Ile Pro Ser Thr Asn Asn Glu 
625                 630                 635                 640 


Thr Pro Gly Ile Arg Tyr Gln Tyr Asn Val Leu Pro Gln Gly Trp Lys 
                645                 650                 655     


Gly Ser Pro Ala Ile Phe Gln Cys Ser Met Thr Arg Ile Leu Glu Pro 
            660                 665                 670         


Phe Arg Ala Lys Asn Pro Glu Ile Val Ile Tyr Gln Tyr Met Ala Ala 
        675                 680                 685             


Leu Tyr Val Gly Ser Asp Leu Glu Ile Gly Gln His Arg Ala Lys Ile 
    690                 695                 700                 


Glu Glu Leu Arg Glu His Leu Leu Lys Trp Gly Phe Thr Thr Pro Asp 
705                 710                 715                 720 


Lys Lys His Gln Lys Glu Pro Pro Phe Leu Trp Met Gly Tyr Glu Leu 
                725                 730                 735     


His Pro Asp Lys Trp Thr Val Gln Pro Ile Gln Leu Pro Glu Lys Asp 
            740                 745                 750         


Ser Trp Thr Val Asn Asp Ile Gln Lys Leu Val Gly Lys Leu Asn Trp 
        755                 760                 765             


Ala Ser Gln Ile Tyr Pro Gly Ile Lys Val Arg Gln Leu Cys Lys Leu 
    770                 775                 780                 


Leu Arg Gly Ala Lys Ala Leu Thr Asp Ile Val Pro Leu Thr Glu Glu 
785                 790                 795                 800 


Ala Glu Leu Glu Leu Ala Glu Asn Arg Glu Ile Leu Lys Glu Pro Val 
                805                 810                 815     


His Gly Val Tyr Tyr Asp Pro Ser Lys Asp Leu Ile Ala Glu Ile Gln 
            820                 825                 830         


Lys Gln Gly His Asp Gln Trp Thr Tyr Gln Ile Tyr Gln Glu Pro Phe 
        835                 840                 845             


Lys Asn Leu Lys Thr Gly Lys Tyr Ala Lys Met Arg Thr Ala His Thr 
    850                 855                 860                 


Asn Asp Val Lys Gln Leu Thr Glu Ala Val Gln Lys Ile Ala Met Glu 
865                 870                 875                 880 


Ser Ile Val Ile Trp Gly Lys Thr Pro Lys Phe Arg Leu Pro Ile Gln 
                885                 890                 895     


Lys Glu Thr Trp Glu Thr Trp Trp Thr Asp Tyr Trp Gln Ala Thr Trp 
            900                 905                 910         


Ile Pro Glu Trp Glu Phe Val Asn Thr Pro Pro Leu Val Lys Leu Trp 
        915                 920                 925             


Tyr Gln Leu Glu Lys Asp Pro Ile Ala Gly Val Glu Thr Phe Tyr Val 
    930                 935                 940                 


Ala Gly Ala Ala Asn Arg Glu Thr Lys Leu Gly Lys Ala Gly Tyr Val 
945                 950                 955                 960 


Thr Asp Arg Gly Arg Gln Lys Ile Val Ser Leu Thr Glu Thr Thr Asn 
                965                 970                 975     


Gln Lys Thr Ala Leu Gln Ala Ile Tyr Leu Ala Leu Gln Asp Ser Gly 
            980                 985                 990         


Ser Glu Val Asn Ile Val Thr Ala  Ser Gln Tyr Ala Leu  Gly Ile Ile 
        995                 1000                 1005             


Gln Ala  Gln Pro Asp Lys Ser  Glu Ser Glu Leu Val  Asn Gln Ile 
    1010                 1015                 1020             


Ile Glu  Gln Leu Ile Lys Lys  Glu Arg Val Tyr Leu  Ser Trp Val 
    1025                 1030                 1035             


Pro Ala  His Lys Gly Ile Gly  Gly Asn Glu Gln Val  Asp Lys Leu 
    1040                 1045                 1050             


Val Ser  Ser Gly Ile Arg Lys  Val Leu Phe Leu Asp  Gly Ile Asp 
    1055                 1060                 1065             


Lys Ala  Gln Glu Glu His Glu  Lys Tyr His Ser Asn  Trp Arg Ala 
    1070                 1075                 1080             


Met Ala  Ser Asp Phe Asn Leu  Pro Pro Val Val Ala  Lys Glu Ile 
    1085                 1090                 1095             


Val Ala  Ser Cys Asp Gln Cys  Gln Leu Lys Gly Glu  Ala Met His 
    1100                 1105                 1110             


Gly Gln  Val Asp Cys Ser Pro  Gly Ile Trp Gln Leu  Ala Cys Thr 
    1115                 1120                 1125             


His Leu  Glu Gly Lys Ile Ile  Leu Val Ala Val His  Val Ala Ser 
    1130                 1135                 1140             


Gly Tyr  Ile Glu Ala Glu Val  Ile Pro Ala Glu Thr  Gly Gln Glu 
    1145                 1150                 1155             


Thr Ala  Tyr Phe Ile Leu Lys  Leu Ala Gly Arg Trp  Pro Val Lys 
    1160                 1165                 1170             


Val Ile  His Thr Ala Asn Gly  Ser Asn Phe Thr Ser  Ala Ala Val 
    1175                 1180                 1185             


Lys Ala  Ala Cys Trp Trp Ala  Gly Ile Gln Gln Glu  Phe Gly Ile 
    1190                 1195                 1200             


Pro Tyr  Asn Pro Gln Ser Gln  Gly Val Val Ala Ser  Met Asn Lys 
    1205                 1210                 1215             


Glu Leu  Lys Lys Ile Ile Gly  Gln Val Arg Asp Gln  Ala Glu His 
    1220                 1225                 1230             


Leu Lys  Thr Ala Val Gln Met  Ala Val Phe Ile His  Asn Phe Lys 
    1235                 1240                 1245             


Arg Lys  Gly Gly Ile Gly Gly  Tyr Ser Ala Gly Glu  Arg Ile Ile 
    1250                 1255                 1260             


Asp Ile  Ile Ala Thr Asp Ile  Gln Thr Lys Glu Leu  Gln Lys Gln 
    1265                 1270                 1275             


Ile Ile  Lys Ile Gln Asn Phe  Arg Val Tyr Tyr Arg  Asp Ser Arg 
    1280                 1285                 1290             


Asp Pro  Ile Trp Lys Gly Pro  Ala Lys Leu Leu Trp  Lys Gly Glu 
    1295                 1300                 1305             


Gly Ala  Val Val Ile Gln Asp  Asn Ser Asp Ile Lys  Val Val Pro 
    1310                 1315                 1320             


Arg Arg  Lys Val Lys Ile Ile  Lys Asp Tyr Gly Lys  Gln Met Ala 
    1325                 1330                 1335             


Gly Ala  Asp Cys Val Ala Gly  Arg Gln Asp Glu Asp  Met Ala Gly 
    1340                 1345                 1350             


Lys Trp  Ser Lys Ser Ser Val  Val Gly Trp Pro Ala  Ile Arg Glu 
    1355                 1360                 1365             


Arg Met  Arg Arg Ala Glu Pro  Ala Ala Asp Gly Val  Gly Ala Val 
    1370                 1375                 1380             


Ser Arg  Asp Leu Glu Lys His  Gly Ala Ile Thr Ser  Ser Asn Thr 
    1385                 1390                 1395             


Ala Ala  Asn Asn Ala Asp Cys  Ala Trp Leu Glu Ala  Gln Glu Glu 
    1400                 1405                 1410             


Glu Glu  Val Gly Phe Pro Val  Arg Pro Gln Val Pro  Leu Arg Pro 
    1415                 1420                 1425             


Met Thr  Tyr Lys Gly Ala Leu  Asp Leu Ser His Phe  Leu Lys Glu 
    1430                 1435                 1440             


Lys Gly  Gly Leu Glu Gly Leu  Ile Tyr Ser Gln Lys  Arg Gln Asp 
    1445                 1450                 1455             


Ile Leu  Asp Leu Trp Val Tyr  His Thr Gln Gly Tyr  Phe Pro Asp 
    1460                 1465                 1470             


Trp Gln  Asn Tyr Thr Pro Gly  Pro Gly Ile Arg Tyr  Pro Leu Thr 
    1475                 1480                 1485             


Phe Gly  Trp Cys Phe Lys Leu  Val Pro Val Glu Pro  Glu Lys Ile 
    1490                 1495                 1500             


Glu Glu  Ala Asn Glu Gly Glu  Asn Asn Ser Leu Leu  His Pro Met 
    1505                 1510                 1515             


Ser Gln  His Gly Met Asp Asp  Pro Glu Lys Glu Val  Leu Met Trp 
    1520                 1525                 1530             


Lys Phe  Asp Ser Arg Leu Ala  Phe His His Met Ala  Arg Glu Leu 
    1535                 1540                 1545             


His Pro  Glu Tyr Tyr Lys Asp  Cys 
    1550                 1555     


<210>  32
<211>  1547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Mosaic gagpolnef2)

<400>  32

Met Gly Ala Arg Ala Ser Ile Leu Arg Gly Gly Lys Leu Asp Lys Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys His Tyr Met Leu Lys 
            20                  25                  30          


His Leu Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Leu Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Ser Glu Gly Cys Lys Gln Ile Ile Lys Gln Leu 
    50                  55                  60                  


Gln Pro Ala Leu Gln Thr Gly Thr Glu Glu Leu Arg Ser Leu Phe Asn 
65                  70                  75                  80  


Thr Val Ala Thr Leu Tyr Cys Val His Ala Glu Ile Glu Val Arg Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Gln 
            100                 105                 110         


Gln Lys Thr Gln Gln Ala Lys Glu Ala Asp Gly Lys Val Ser Gln Asn 
        115                 120                 125             


Tyr Pro Ile Val Gln Asn Leu Gln Gly Gln Met Val His Gln Pro Ile 
    130                 135                 140                 


Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Ile Glu Glu Lys Ala 
145                 150                 155                 160 


Phe Ser Pro Glu Val Ile Pro Met Phe Thr Ala Leu Ser Glu Gly Ala 
                165                 170                 175     


Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly Gly His Gln 
            180                 185                 190         


Ala Ala Met Gln Met Leu Lys Asp Thr Ile Asn Glu Glu Ala Ala Glu 
        195                 200                 205             


Trp Asp Arg Leu His Pro Val His Ala Gly Pro Val Ala Pro Gly Gln 
    210                 215                 220                 


Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr Ser Asn Leu 
225                 230                 235                 240 


Gln Glu Gln Ile Ala Trp Met Thr Ser Asn Pro Pro Ile Pro Val Gly 
                245                 250                 255     


Asp Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg 
            260                 265                 270         


Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Lys Gln Gly Pro Lys Glu 
        275                 280                 285             


Pro Phe Arg Asp Tyr Val Asp Arg Phe Phe Lys Thr Leu Arg Ala Glu 
    290                 295                 300                 


Gln Ala Thr Gln Asp Val Lys Asn Trp Met Thr Asp Thr Leu Leu Val 
305                 310                 315                 320 


Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Arg Ala Leu Gly Pro 
                325                 330                 335     


Gly Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly Val Gly Gly 
            340                 345                 350         


Pro Ser His Lys Ala Arg Val Leu Ala Glu Ala Met Ser Gln Thr Asn 
        355                 360                 365             


Ser Thr Ile Leu Met Gln Arg Ser Asn Phe Lys Gly Ser Lys Arg Ile 
    370                 375                 380                 


Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His Ile Ala Arg Asn Cys 
385                 390                 395                 400 


Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys Gly Lys Glu Gly His 
                405                 410                 415     


Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn Phe Leu Gly Lys Ile 
            420                 425                 430         


Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe Leu Gln Ser Arg Pro 
        435                 440                 445             


Glu Pro Thr Ala Pro Pro Ala Glu Ser Phe Arg Phe Glu Glu Thr Thr 
    450                 455                 460                 


Pro Ala Pro Lys Gln Glu Pro Lys Asp Arg Glu Pro Leu Thr Ser Leu 
465                 470                 475                 480 


Arg Ser Leu Phe Gly Ser Asp Pro Leu Ser Gln Met Ala Pro Ile Ser 
                485                 490                 495     


Pro Ile Glu Thr Val Pro Val Lys Leu Lys Pro Gly Met Asp Gly Pro 
            500                 505                 510         


Lys Val Lys Gln Trp Pro Leu Thr Glu Glu Lys Ile Lys Ala Leu Val 
        515                 520                 525             


Glu Ile Cys Thr Glu Met Glu Lys Glu Gly Lys Ile Ser Lys Ile Gly 
    530                 535                 540                 


Pro Glu Asn Pro Tyr Asn Thr Pro Ile Phe Ala Ile Lys Lys Lys Asp 
545                 550                 555                 560 


Ser Thr Lys Trp Arg Lys Leu Val Asp Phe Arg Glu Leu Asn Lys Arg 
                565                 570                 575     


Thr Gln Asp Phe Trp Glu Val Gln Leu Gly Ile Pro His Pro Ala Gly 
            580                 585                 590         


Leu Lys Lys Lys Lys Ser Val Thr Val Leu Ala Val Gly Asp Ala Tyr 
        595                 600                 605             


Phe Ser Val Pro Leu Asp Glu Asp Phe Arg Lys Tyr Thr Ala Phe Thr 
    610                 615                 620                 


Ile Pro Ser Ile Asn Asn Glu Thr Pro Gly Ile Arg Tyr Gln Tyr Asn 
625                 630                 635                 640 


Val Leu Pro Gln Gly Trp Lys Gly Ser Pro Ala Ile Phe Gln Ser Ser 
                645                 650                 655     


Met Thr Lys Ile Leu Glu Pro Phe Arg Lys Gln Asn Pro Asp Ile Val 
            660                 665                 670         


Ile Tyr Gln Tyr Met Ala Ala Leu Tyr Val Gly Ser Asp Leu Glu Ile 
        675                 680                 685             


Gly Gln His Arg Thr Lys Ile Glu Glu Leu Arg Gln His Leu Leu Arg 
    690                 695                 700                 


Trp Gly Phe Thr Thr Pro Asp Lys Lys His Gln Lys Glu Pro Pro Phe 
705                 710                 715                 720 


Leu Trp Met Gly Tyr Glu Leu His Pro Asp Lys Trp Thr Val Gln Pro 
                725                 730                 735     


Ile Val Leu Pro Glu Lys Asp Ser Trp Thr Val Asn Asp Ile Gln Lys 
            740                 745                 750         


Leu Val Gly Lys Leu Asn Trp Ala Ser Gln Ile Tyr Ala Gly Ile Lys 
        755                 760                 765             


Val Lys Gln Leu Cys Lys Leu Leu Arg Gly Thr Lys Ala Leu Thr Glu 
    770                 775                 780                 


Val Val Pro Leu Thr Glu Glu Ala Glu Leu Glu Leu Ala Glu Asn Arg 
785                 790                 795                 800 


Glu Ile Leu Lys Glu Pro Val His Gly Val Tyr Tyr Asp Pro Ser Lys 
                805                 810                 815     


Asp Leu Ile Ala Glu Ile Gln Lys Gln Gly Gln Gly Gln Trp Thr Tyr 
            820                 825                 830         


Gln Ile Tyr Gln Glu Pro Phe Lys Asn Leu Lys Thr Gly Lys Tyr Ala 
        835                 840                 845             


Arg Met Arg Gly Ala His Thr Asn Asp Val Lys Gln Leu Thr Glu Ala 
    850                 855                 860                 


Val Gln Lys Ile Ala Thr Glu Ser Ile Val Ile Trp Gly Lys Thr Pro 
865                 870                 875                 880 


Lys Phe Lys Leu Pro Ile Gln Lys Glu Thr Trp Glu Ala Trp Trp Thr 
                885                 890                 895     


Glu Tyr Trp Gln Ala Thr Trp Ile Pro Glu Trp Glu Phe Val Asn Thr 
            900                 905                 910         


Pro Pro Leu Val Lys Leu Trp Tyr Gln Leu Glu Lys Glu Pro Ile Val 
        915                 920                 925             


Gly Ala Glu Thr Phe Tyr Val Ala Gly Ala Ala Asn Arg Glu Thr Lys 
    930                 935                 940                 


Leu Gly Lys Ala Gly Tyr Val Thr Asp Arg Gly Arg Gln Lys Val Val 
945                 950                 955                 960 


Ser Leu Thr Asp Thr Thr Asn Gln Lys Thr Ala Leu Gln Ala Ile His 
                965                 970                 975     


Leu Ala Leu Gln Asp Ser Gly Leu Glu Val Asn Ile Val Thr Ala Ser 
            980                 985                 990         


Gln Tyr Ala Leu Gly Ile Ile Gln  Ala Gln Pro Asp Lys  Ser Glu Ser 
        995                 1000                 1005             


Glu Leu  Val Ser Gln Ile Ile  Glu Gln Leu Ile Lys  Lys Glu Lys 
    1010                 1015                 1020             


Val Tyr  Leu Ala Trp Val Pro  Ala His Lys Gly Ile  Gly Gly Asn 
    1025                 1030                 1035             


Glu Gln  Val Asp Lys Leu Val  Ser Arg Gly Ile Arg  Lys Val Leu 
    1040                 1045                 1050             


Phe Leu  Asp Gly Ile Asp Lys  Ala Gln Glu Glu His  Glu Lys Tyr 
    1055                 1060                 1065             


His Ser  Asn Trp Arg Ala Met  Ala Ser Glu Phe Asn  Leu Pro Pro 
    1070                 1075                 1080             


Ile Val  Ala Lys Glu Ile Val  Ala Ser Cys Asp Lys  Cys Gln Leu 
    1085                 1090                 1095             


Lys Gly  Glu Ala Ile His Gly  Gln Val Asp Cys Ser  Pro Gly Ile 
    1100                 1105                 1110             


Trp Gln  Leu Ala Cys Thr His  Leu Glu Gly Lys Val  Ile Leu Val 
    1115                 1120                 1125             


Ala Val  His Val Ala Ser Gly  Tyr Ile Glu Ala Glu  Val Ile Pro 
    1130                 1135                 1140             


Ala Glu  Thr Gly Gln Glu Thr  Ala Tyr Phe Leu Leu  Lys Leu Ala 
    1145                 1150                 1155             


Gly Arg  Trp Pro Val Lys Thr  Ile His Thr Ala Asn  Gly Ser Asn 
    1160                 1165                 1170             


Phe Thr  Ser Ala Thr Val Lys  Ala Ala Cys Trp Trp  Ala Gly Ile 
    1175                 1180                 1185             


Lys Gln  Glu Phe Gly Ile Pro  Tyr Asn Pro Gln Ser  Gln Gly Val 
    1190                 1195                 1200             


Val Ala  Ser Ile Asn Lys Glu  Leu Lys Lys Ile Ile  Gly Gln Val 
    1205                 1210                 1215             


Arg Asp  Gln Ala Glu His Leu  Lys Thr Ala Val Gln  Met Ala Val 
    1220                 1225                 1230             


Phe Ile  His Asn Phe Lys Arg  Lys Gly Gly Ile Gly  Glu Tyr Ser 
    1235                 1240                 1245             


Ala Gly  Glu Arg Ile Val Asp  Ile Ile Ala Ser Asp  Ile Gln Thr 
    1250                 1255                 1260             


Lys Glu  Leu Gln Lys Gln Ile  Thr Lys Ile Gln Asn  Phe Arg Val 
    1265                 1270                 1275             


Tyr Tyr  Arg Asp Ser Arg Asp  Pro Leu Trp Lys Gly  Pro Ala Lys 
    1280                 1285                 1290             


Leu Leu  Trp Lys Gly Glu Gly  Ala Val Val Ile Gln  Asp Asn Ser 
    1295                 1300                 1305             


Asp Ile  Lys Val Val Pro Arg  Arg Lys Ala Lys Ile  Ile Arg Asp 
    1310                 1315                 1320             


Tyr Gly  Lys Gln Met Ala Gly  Asp Asp Cys Val Ala  Ser Arg Gln 
    1325                 1330                 1335             


Asp Glu  Asp Met Ala Gly Lys  Trp Ser Lys Ser Ser  Ile Val Gly 
    1340                 1345                 1350             


Trp Pro  Ala Val Arg Glu Arg  Ile Arg Arg Ala Glu  Pro Ala Ala 
    1355                 1360                 1365             


Glu Gly  Val Gly Ala Ala Ser  Gln Asp Leu Asp Lys  Tyr Gly Ala 
    1370                 1375                 1380             


Leu Thr  Ser Ser Asn Thr Ala  Ala Thr Asn Ala Asp  Cys Ala Trp 
    1385                 1390                 1395             


Leu Glu  Ala Gln Glu Asp Glu  Glu Val Gly Phe Pro  Val Lys Pro 
    1400                 1405                 1410             


Gln Val  Pro Leu Arg Pro Met  Thr Tyr Lys Ala Ala  Phe Asp Leu 
    1415                 1420                 1425             


Ser Phe  Phe Leu Lys Glu Lys  Gly Gly Leu Asp Gly  Leu Ile Tyr 
    1430                 1435                 1440             


Ser Lys  Lys Arg Gln Glu Ile  Leu Asp Leu Trp Val  Tyr Asn Thr 
    1445                 1450                 1455             


Gln Gly  Phe Phe Pro Asp Trp  Gln Asn Tyr Thr Pro  Gly Pro Gly 
    1460                 1465                 1470             


Val Arg  Tyr Pro Leu Thr Phe  Gly Trp Cys Phe Lys  Leu Val Pro 
    1475                 1480                 1485             


Val Asp  Pro Arg Glu Val Glu  Glu Ala Asn Lys Gly  Glu Asn Asn 
    1490                 1495                 1500             


Cys Leu  Leu His Pro Met Asn  Leu His Gly Met Asp  Asp Pro Glu 
    1505                 1510                 1515             


Arg Glu  Val Leu Val Trp Arg  Phe Asp Ser Arg Leu  Ala Phe His 
    1520                 1525                 1530             


His Met  Ala Arg Glu Lys His  Pro Glu Tyr Tyr Lys  Asn Cys 
    1535                 1540                 1545         


