                         SEQUENCE LISTING

<110>  SANOFI
       INSERM
       UNIVERSITE DE MONTPELLIER 1
       CENTRE VAL D'AURELLE- PAUL LAMARQUE
       UNIVERSITE DE MONTPELLIER 2 SCIENCES ET TECHNIQUES
 
<120>  Intracellular phenotypic screening

<130>  B09196A

<150>  EP 13305003.9
<151>  03 JANUARY 2013

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intracellular antibody 3H2-1


<220>
<221>  DOMAIN
<222>  (3)..(118)
<223>  VH

<220>
<221>  DOMAIN
<222>  (101)..(107)
<223>  VH_CDR3

<220>
<221>  DOMAIN
<222>  (134)..(243)
<223>  VL

<220>
<221>  DOMAIN
<222>  (224)..(233)
<223>  VL_CDR3

<400>  1

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Ser Leu Val Lys Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Ser Ser Ile Ser Gly Ser Ser Arg Tyr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Thr Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg Pro Ile Ala Val Ser Asp Tyr Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser 
    130                 135                 140                 


Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Ala Gly Thr Ser Ser 
145                 150                 155                 160 


Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Met Ile Tyr Glu Asp Ser Lys Arg Pro Ser Gly 
            180                 185                 190         


Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu 
        195                 200                 205             


Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln 
    210                 215                 220                 


Thr Tyr Asp Gly Ser Arg Ala Val Phe Gly Gly Gly Thr Lys Leu Ala 
225                 230                 235                 240 


Val Leu Gly Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
                245                 250                 255     


Asn Gly Ala Ala 
            260 


<210>  2
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intracellular antibody 3H2-VH


<220>
<221>  DOMAIN
<222>  (3)..(121)
<223>  VH

<220>
<221>  DOMAIN
<222>  (101)..(110)
<223>  VH_CDR3

<400>  2

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Ser Leu Val Lys Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Ser Ser Ile Ser Gly Ser Ser Arg Tyr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Thr Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg Gly Val Arg Gly Gly Tyr Gly Leu Asp Phe Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Thr Lys Leu Ala Val Leu Gly Ala Ala Ala Glu Gln Lys Leu Ile 
    130                 135                 140                 


Ser Glu Glu Asp Leu Asn Gly Ala Ala 
145                 150             


<210>  3
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intracellular antibody 5H4


<220>
<221>  DOMAIN
<222>  (3)..(121)
<223>  VH

<220>
<221>  DOMAIN
<222>  (101)..(110)
<223>  VH_CDR3

<400>  3

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Ser Leu Val Lys Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Ser Ser Ile Ser Gly Ser Ser Arg Tyr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Thr Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg Asp Gly Gly Leu Arg Glu Gly Phe Asp Cys Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Ala 
    130                 135                 140                 


Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Ala Gly 
145                 150                 155                 160 


Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln 
                165                 170                 175     


His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Asp Ser Lys Arg 
            180                 185                 190         


Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr 
        195                 200                 205             


Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Pro Ser 
225             


<210>  4
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intracellular antibody 5H4-VH


<220>
<221>  DOMAIN
<222>  (3)..(121)
<223>  VH

<220>
<221>  DOMAIN
<222>  (101)..(110)
<223>  VH_CDR3

<400>  4

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Ser Leu Val Lys Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Ser Ser Ile Ser Gly Ser Ser Arg Tyr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Thr Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg Asp Gly Gly Leu Arg Glu Gly Phe Asp Cys Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln Lys Leu 
        115                 120                 125             


Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala 
    130                 135             


<210>  5
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intracellular antibody 5H4-VL


<220>
<221>  DOMAIN
<222>  (3)..(121)
<223>  VH

<220>
<221>  DOMAIN
<222>  (101)..(110)
<223>  VH_CDR3

<400>  5

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Ser Leu Val Lys Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Ser Ser Ile Ser Gly Ser Ser Arg Tyr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Thr Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg Asp Gly Gly Leu Arg Glu Gly Phe Asp Cys Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Ala 
    130                 135                 140                 


Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Ala Gly 
145                 150                 155                 160 


Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln 
                165                 170                 175     


His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Asp Ser Lys Arg 
            180                 185                 190         


Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr 
        195                 200                 205             


Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
225                 230                 235                 240 


Gly Ala Ala 
            


<210>  6
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intracellular antibody 13R4


<220>
<221>  DOMAIN
<222>  (3)..(123)
<223>  VH

<220>
<221>  DOMAIN
<222>  (3)..(32)
<223>  VH_FR1

<220>
<221>  DOMAIN
<222>  (33)..(37)
<223>  VH_CDR1

<220>
<221>  DOMAIN
<222>  (38)..(51)
<223>  VH_FR2

<220>
<221>  DOMAIN
<222>  (52)..(68)
<223>  VH_CDR2

<220>
<221>  DOMAIN
<222>  (69)..(100)
<223>  VH_FR3

<220>
<221>  DOMAIN
<222>  (101)..(112)
<223>  VH_CDR3

<220>
<221>  DOMAIN
<222>  (113)..(123)
<223>  VH_FR4

<220>
<221>  DOMAIN
<222>  (139)..(249)
<223>  VL

<220>
<221>  DOMAIN
<222>  (139)..(160)
<223>  VL_FR1

<220>
<221>  DOMAIN
<222>  (161)..(174)
<223>  VL_CDR1

<220>
<221>  DOMAIN
<222>  (175)..(189)
<223>  VL_FR2

<220>
<221>  DOMAIN
<222>  (190)..(196)
<223>  VL_CDR2

<220>
<221>  DOMAIN
<222>  (197)..(228)
<223>  VL_FR3

<220>
<221>  DOMAIN
<222>  (229)..(239)
<223>  VL_CDR3

<220>
<221>  DOMAIN
<222>  (240)..(249)
<223>  VL_FR4

<400>  6

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Ser Leu Val Lys Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Ser Ser Ile Ser Gly Ser Ser Arg Tyr Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Thr Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg Ser Ser Ile Thr Ile Phe Gly Gly Gly Met Asp Val 
            100                 105                 110         


Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln 
    130                 135                 140                 


Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys 
145                 150                 155                 160 


Ala Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr 
                165                 170                 175     


Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Asp Ser 
            180                 185                 190         


Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly 
        195                 200                 205             


Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala 
    210                 215                 220                 


Asp Tyr Tyr Cys Ser Ser Tyr Thr Thr Arg Ser Thr Arg Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Ala Val Leu Gly Ala Ala Ala Glu Gln Lys Leu 
                245                 250                 255     


Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala 
            260                 265     


<210>  7
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VH chain of an intracellular antibody of cluster R_1

<400>  7

Met Asp Cys Val Ile Gly Ser Tyr Gly Tyr Gly Ile Phe Asp Thr 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VH chain of an intracellular antibody of cluster R_2

<400>  8

Gly Lys Val Leu Lys Lys Ala Glu Tyr Ser Asp Trp Leu Asp Asn 
1               5                   10                  15  


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VH chain of an intracellular antibody of cluster R_3

<400>  9

Arg Ser Ala Ser Cys Glu His 
1               5           


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VH chain of an intracellular antibody of cluster  R_4

<400>  10

Gly Glu Val Gly Phe Asp Tyr 
1               5           


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VH chain of an intracellular antibody of cluster R_5

<400>  11

Thr Leu Glu Cys Ser Arg Cys Gly Asp Tyr Gly Phe Asp Leu 
1               5                   10                  


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VH chain of an intracellular antibody of cluster R_6

<400>  12

Asp Gly Leu Tyr Ala Arg Met Tyr Tyr Asn Gly Ser Tyr Tyr 
1               5                   10                  


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VH chain of an intracellular antibody of cluster R_7

<400>  13

Glu Arg Arg Asp Asp Asp Gly Met Tyr Ala Tyr Ser Tyr Gln Phe Asp 
1               5                   10                  15      


Val 
    


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VH chain of an intracellular antibody of cluster R_9

<400>  14

Asn Pro Ala Ser Lys Cys Val Tyr Leu Glu His Asp Phe Glu Lys 
1               5                   10                  15  


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VH chain of an intracellular antibody of cluster R_10

<400>  15

Pro Glu Arg Ser Ala Tyr Asp Tyr 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VH chain of an intracellular antibody of cluster D_1

<400>  16

Gly Asp Ser His Ile Ile Asp Cys 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VH chain of an intracellular antibody of cluster D_2

<400>  17

Gly Ser Thr Ala Gly Phe Asp Tyr 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VH chain of an intracellular antibody of cluster D_3

<400>  18

Glu Glu Gly Val Asp Ile Glu Tyr 
1               5               


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VL chain of an intracellular antibody of cluster R_1

<400>  19

Gln Ser Phe Val Arg Asn Ser Thr Ser 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VL chain of an intracellular antibody of cluster R_2

<400>  20

Gln Gln Cys Ser Lys Phe Pro Leu Thr 
1               5                   


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VL chain of an intracellular antibody of cluster R_3

<400>  21

Glu Gln Tyr Asp Thr Ala Pro Pro Tyr Thr 
1               5                   10  


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VL chain of an intracellular antibody of cluster R_4

<400>  22

Gln Gln Tyr Phe Ser Gln Pro Phe Thr 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VL chain of an intracellular antibody of cluster R_5

<400>  23

His Gln Ser Asn Thr Tyr Pro Phe Thr 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VL chain of an intracellular antibody of cluster R_6

<400>  24

Gln Gln Tyr Phe Ser Gln Pro Phe Thr 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VL chain of an intracellular antibody of cluster R_9

<400>  25

Gln Thr Cys Asn Cys Leu Thr Leu Val 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VL chain of an intracellular antibody of cluster R_10

<400>  26

Gln Gln Tyr Ser Ser His Pro Leu Thr 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VL chain of an intracellular antibody of cluster D_1

<400>  27

Gln Gln Ser Asn Ile Leu Ser Val Thr 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VL chain of an intracellular antibody of cluster D_2

<400>  28

Gln Gln Asp Asp Ser Thr Pro Tyr Thr 
1               5                   


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the VL chain of an intracellular antibody of cluster D_3

<400>  29

Pro Ser Leu Asn Asn Ser Leu Thr Tyr Ile Val 
1               5                   10      


<210>  30
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sense strand of sh1 shRNA to LOC297607

<400>  30
gatccgcatt ctaatctctc ggaaattcaa gagatttccg agagattaga atgttttttt       60

ctagag                                                                  66


<210>  31
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sense strand of sh2 shRNA to LOC297607

<400>  31
gatccgagaa ttgattggcg aaagattcaa gagatctttc gccaatcaat tctttttttt       60

ctagag                                                                  66


<210>  32
<211>  1659
<212>  DNA
<213>  Rattus norvegicus


<220>
<221>  CDS
<222>  (1)..(1659)
<223>  Protein LOC297607

<400>  32
atg aag aaa aac cga gaa agg ttc tcc agc aag gaa aga gaa ttc gtg         48
Met Lys Lys Asn Arg Glu Arg Phe Ser Ser Lys Glu Arg Glu Phe Val           
1               5                   10                  15                

tac aaa ttc cag ata gga agt gag cgc tta gaa ctg aga gtg ccc ctc         96
Tyr Lys Phe Gln Ile Gly Ser Glu Arg Leu Glu Leu Arg Val Pro Leu           
            20                  25                  30                    

agg ttt ccc gtg gac gag aat gcc agt cat ctg cat gga cgt ctg atg        144
Arg Phe Pro Val Asp Glu Asn Ala Ser His Leu His Gly Arg Leu Met           
        35                  40                  45                        

ctg ctg cac agt ttg ccc tgc ttc ata gag aat gac tta aaa gaa gct        192
Leu Leu His Ser Leu Pro Cys Phe Ile Glu Asn Asp Leu Lys Glu Ala           
    50                  55                  60                            

ctg gcc cgg ttt ata gaa gaa gag tcc ctc aga gac cat gac agc gat        240
Leu Ala Arg Phe Ile Glu Glu Glu Ser Leu Arg Asp His Asp Ser Asp           
65                  70                  75                  80            

gca gaa gca tgc ttg gag gcg gtt aag tct ggt gag gta gat cta cac        288
Ala Glu Ala Cys Leu Glu Ala Val Lys Ser Gly Glu Val Asp Leu His           
                85                  90                  95                

cag ctg gcg agt aca tgg gcc aaa gcg tat gct gag aca acc cta gag        336
Gln Leu Ala Ser Thr Trp Ala Lys Ala Tyr Ala Glu Thr Thr Leu Glu           
            100                 105                 110                   

cat gcg aga cct gag gag cct aac tgg gat gaa gac ttt gca gat gtg        384
His Ala Arg Pro Glu Glu Pro Asn Trp Asp Glu Asp Phe Ala Asp Val           
        115                 120                 125                       

tac cat gac cta atc cat tct ccg gcc tct gag act ctc tta aat ctg        432
Tyr His Asp Leu Ile His Ser Pro Ala Ser Glu Thr Leu Leu Asn Leu           
    130                 135                 140                           

gaa cac aat tac ttt gtt agc atc tca gaa ttg att ggc gaa aga gat        480
Glu His Asn Tyr Phe Val Ser Ile Ser Glu Leu Ile Gly Glu Arg Asp           
145                 150                 155                 160           

gtg gag ctg aaa aag tta cga gag aga caa ggc att gaa atg gaa aag        528
Val Glu Leu Lys Lys Leu Arg Glu Arg Gln Gly Ile Glu Met Glu Lys           
                165                 170                 175               

gtg atg cag gaa ctg ggg aag tcg ctc aca gat caa gat gtg aac tca        576
Val Met Gln Glu Leu Gly Lys Ser Leu Thr Asp Gln Asp Val Asn Ser           
            180                 185                 190                   

ctg gct gcc cag cac ttt gaa tcc cag cag gac tta gag aat aaa tgg        624
Leu Ala Ala Gln His Phe Glu Ser Gln Gln Asp Leu Glu Asn Lys Trp           
        195                 200                 205                       

tca aac gaa ctg aaa cag tct aca gct atc cag aag caa gaa tat cag        672
Ser Asn Glu Leu Lys Gln Ser Thr Ala Ile Gln Lys Gln Glu Tyr Gln           
    210                 215                 220                           

gaa tgg gtg ata aag ctt cat cag gac cta aaa aac ccc aac aac agc        720
Glu Trp Val Ile Lys Leu His Gln Asp Leu Lys Asn Pro Asn Asn Ser           
225                 230                 235                 240           

tcc ctc agt gaa gaa att aaa gtg cag ccg agt cag ttc agg gaa tct        768
Ser Leu Ser Glu Glu Ile Lys Val Gln Pro Ser Gln Phe Arg Glu Ser           
                245                 250                 255               

gcg gac gcc gct gga agg atc tat gag gag cag agg aag ctg gaa gaa        816
Ala Asp Ala Ala Gly Arg Ile Tyr Glu Glu Gln Arg Lys Leu Glu Glu           
            260                 265                 270                   

agc ttc acc att cac ctg gga gcc cag ttg aag acc atg cac aat ctg        864
Ser Phe Thr Ile His Leu Gly Ala Gln Leu Lys Thr Met His Asn Leu           
        275                 280                 285                       

cgg ttg ctg agg gca gac atg ctg gac ttc tgt aag cac aag aga acg        912
Arg Leu Leu Arg Ala Asp Met Leu Asp Phe Cys Lys His Lys Arg Thr           
    290                 295                 300                           

cag ggg agc ggc gtg aag ctc cac cgg ctc cag acg gca ctg tcc ctt        960
Gln Gly Ser Gly Val Lys Leu His Arg Leu Gln Thr Ala Leu Ser Leu           
305                 310                 315                 320           

tac tcc acg tcc ctc tgt ggc ctg gtt tta cta gta gac aat cgg att       1008
Tyr Ser Thr Ser Leu Cys Gly Leu Val Leu Leu Val Asp Asn Arg Ile           
                325                 330                 335               

aat tca tat agc ggc atc aaa aga gat ttt gcc aca gtt tgc caa gaa       1056
Asn Ser Tyr Ser Gly Ile Lys Arg Asp Phe Ala Thr Val Cys Gln Glu           
            340                 345                 350                   

tgc acg gac ttc cac ttc ccg cgg att gag gag caa ctg gag gtt gtc       1104
Cys Thr Asp Phe His Phe Pro Arg Ile Glu Glu Gln Leu Glu Val Val           
        355                 360                 365                       

cag cag gtg gcg ctg tac gca cga acc cag cgc agg agc aag tgc aag       1152
Gln Gln Val Ala Leu Tyr Ala Arg Thr Gln Arg Arg Ser Lys Cys Lys           
    370                 375                 380                           

gag gca cgc gat tct gga aac caa aat gga gga agt gat gag aaa tct       1200
Glu Ala Arg Asp Ser Gly Asn Gln Asn Gly Gly Ser Asp Glu Lys Ser           
385                 390                 395                 400           

aag aat gct gag aga aac tat tta aat att tta cca gga gaa ttt tat       1248
Lys Asn Ala Glu Arg Asn Tyr Leu Asn Ile Leu Pro Gly Glu Phe Tyr           
                405                 410                 415               

att aca cgt cat tct aat ctc tcg gaa atc cac gtt gct ttc cat ctc       1296
Ile Thr Arg His Ser Asn Leu Ser Glu Ile His Val Ala Phe His Leu           
            420                 425                 430                   

tgt gtg gat gac aac gtg aag tca gga aac atc act gct cgg gat ccc       1344
Cys Val Asp Asp Asn Val Lys Ser Gly Asn Ile Thr Ala Arg Asp Pro           
        435                 440                 445                       

gct att atg gga ctc cga aat ata ctc aag gtt tgc tgt acc cac gat       1392
Ala Ile Met Gly Leu Arg Asn Ile Leu Lys Val Cys Cys Thr His Asp           
    450                 455                 460                           

atc aca acg ata agc atc cct ctc ttg ctg gtg cat gat atg tca gag       1440
Ile Thr Thr Ile Ser Ile Pro Leu Leu Leu Val His Asp Met Ser Glu           
465                 470                 475                 480           

gaa atg act ata cct tgg tgc tta agg aga gct gaa ctg gtg ttt aag       1488
Glu Met Thr Ile Pro Trp Cys Leu Arg Arg Ala Glu Leu Val Phe Lys           
                485                 490                 495               

tgt gtc aaa ggt ttc atg atg gag atg gct tca tgg gat gga gga att       1536
Cys Val Lys Gly Phe Met Met Glu Met Ala Ser Trp Asp Gly Gly Ile           
            500                 505                 510                   

tct cgg aca gtg caa ttt ctg gta cca cag agc att tct gaa gaa atg       1584
Ser Arg Thr Val Gln Phe Leu Val Pro Gln Ser Ile Ser Glu Glu Met           
        515                 520                 525                       

ttt tat cag ctg agt aac atg ctc cca cag atc ttc cgg gtc tcc tca       1632
Phe Tyr Gln Leu Ser Asn Met Leu Pro Gln Ile Phe Arg Val Ser Ser           
    530                 535                 540                           

aca ctc act ctg aca tcc aag cac taa                                   1659
Thr Leu Thr Leu Thr Ser Lys His                                           
545                 550                                                   


<210>  33
<211>  552
<212>  PRT
<213>  Rattus norvegicus

<400>  33

Met Lys Lys Asn Arg Glu Arg Phe Ser Ser Lys Glu Arg Glu Phe Val 
1               5                   10                  15      


Tyr Lys Phe Gln Ile Gly Ser Glu Arg Leu Glu Leu Arg Val Pro Leu 
            20                  25                  30          


Arg Phe Pro Val Asp Glu Asn Ala Ser His Leu His Gly Arg Leu Met 
        35                  40                  45              


Leu Leu His Ser Leu Pro Cys Phe Ile Glu Asn Asp Leu Lys Glu Ala 
    50                  55                  60                  


Leu Ala Arg Phe Ile Glu Glu Glu Ser Leu Arg Asp His Asp Ser Asp 
65                  70                  75                  80  


Ala Glu Ala Cys Leu Glu Ala Val Lys Ser Gly Glu Val Asp Leu His 
                85                  90                  95      


Gln Leu Ala Ser Thr Trp Ala Lys Ala Tyr Ala Glu Thr Thr Leu Glu 
            100                 105                 110         


His Ala Arg Pro Glu Glu Pro Asn Trp Asp Glu Asp Phe Ala Asp Val 
        115                 120                 125             


Tyr His Asp Leu Ile His Ser Pro Ala Ser Glu Thr Leu Leu Asn Leu 
    130                 135                 140                 


Glu His Asn Tyr Phe Val Ser Ile Ser Glu Leu Ile Gly Glu Arg Asp 
145                 150                 155                 160 


Val Glu Leu Lys Lys Leu Arg Glu Arg Gln Gly Ile Glu Met Glu Lys 
                165                 170                 175     


Val Met Gln Glu Leu Gly Lys Ser Leu Thr Asp Gln Asp Val Asn Ser 
            180                 185                 190         


Leu Ala Ala Gln His Phe Glu Ser Gln Gln Asp Leu Glu Asn Lys Trp 
        195                 200                 205             


Ser Asn Glu Leu Lys Gln Ser Thr Ala Ile Gln Lys Gln Glu Tyr Gln 
    210                 215                 220                 


Glu Trp Val Ile Lys Leu His Gln Asp Leu Lys Asn Pro Asn Asn Ser 
225                 230                 235                 240 


Ser Leu Ser Glu Glu Ile Lys Val Gln Pro Ser Gln Phe Arg Glu Ser 
                245                 250                 255     


Ala Asp Ala Ala Gly Arg Ile Tyr Glu Glu Gln Arg Lys Leu Glu Glu 
            260                 265                 270         


Ser Phe Thr Ile His Leu Gly Ala Gln Leu Lys Thr Met His Asn Leu 
        275                 280                 285             


Arg Leu Leu Arg Ala Asp Met Leu Asp Phe Cys Lys His Lys Arg Thr 
    290                 295                 300                 


Gln Gly Ser Gly Val Lys Leu His Arg Leu Gln Thr Ala Leu Ser Leu 
305                 310                 315                 320 


Tyr Ser Thr Ser Leu Cys Gly Leu Val Leu Leu Val Asp Asn Arg Ile 
                325                 330                 335     


Asn Ser Tyr Ser Gly Ile Lys Arg Asp Phe Ala Thr Val Cys Gln Glu 
            340                 345                 350         


Cys Thr Asp Phe His Phe Pro Arg Ile Glu Glu Gln Leu Glu Val Val 
        355                 360                 365             


Gln Gln Val Ala Leu Tyr Ala Arg Thr Gln Arg Arg Ser Lys Cys Lys 
    370                 375                 380                 


Glu Ala Arg Asp Ser Gly Asn Gln Asn Gly Gly Ser Asp Glu Lys Ser 
385                 390                 395                 400 


Lys Asn Ala Glu Arg Asn Tyr Leu Asn Ile Leu Pro Gly Glu Phe Tyr 
                405                 410                 415     


Ile Thr Arg His Ser Asn Leu Ser Glu Ile His Val Ala Phe His Leu 
            420                 425                 430         


Cys Val Asp Asp Asn Val Lys Ser Gly Asn Ile Thr Ala Arg Asp Pro 
        435                 440                 445             


Ala Ile Met Gly Leu Arg Asn Ile Leu Lys Val Cys Cys Thr His Asp 
    450                 455                 460                 


Ile Thr Thr Ile Ser Ile Pro Leu Leu Leu Val His Asp Met Ser Glu 
465                 470                 475                 480 


Glu Met Thr Ile Pro Trp Cys Leu Arg Arg Ala Glu Leu Val Phe Lys 
                485                 490                 495     


Cys Val Lys Gly Phe Met Met Glu Met Ala Ser Trp Asp Gly Gly Ile 
            500                 505                 510         


Ser Arg Thr Val Gln Phe Leu Val Pro Gln Ser Ile Ser Glu Glu Met 
        515                 520                 525             


Phe Tyr Gln Leu Ser Asn Met Leu Pro Gln Ile Phe Arg Val Ser Ser 
    530                 535                 540                 


Thr Leu Thr Leu Thr Ser Lys His 
545                 550         


<210>  34
<211>  1659
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1659)
<223>  Protein C12ORF4

<400>  34
atg aag aaa aac aga gaa aga ttc tgc aat aga gag aga gaa ttt gta         48
Met Lys Lys Asn Arg Glu Arg Phe Cys Asn Arg Glu Arg Glu Phe Val           
1               5                   10                  15                

tat aaa ttt aaa gta gga agt cag tgc tta gaa ctg aga gtg cca ctc         96
Tyr Lys Phe Lys Val Gly Ser Gln Cys Leu Glu Leu Arg Val Pro Leu           
            20                  25                  30                    

aaa ttt cct gtt caa gag aat gcc agt cat ttg cat gga cgt ctg atg        144
Lys Phe Pro Val Gln Glu Asn Ala Ser His Leu His Gly Arg Leu Met           
        35                  40                  45                        

ctg ctg cac agt tta ccg tgc ttt ata gaa aaa gac tta aaa gaa gct        192
Leu Leu His Ser Leu Pro Cys Phe Ile Glu Lys Asp Leu Lys Glu Ala           
    50                  55                  60                            

ctg act cag ttt ata gaa gaa gaa tcc ctc agc gat tat gat aga gat        240
Leu Thr Gln Phe Ile Glu Glu Glu Ser Leu Ser Asp Tyr Asp Arg Asp           
65                  70                  75                  80            

gct gaa gca tcc ctg gca gct gtg aaa tca ggt gaa gta gat tta cat        288
Ala Glu Ala Ser Leu Ala Ala Val Lys Ser Gly Glu Val Asp Leu His           
                85                  90                  95                

cag ctg gcg agt aca tgg gcc aaa gct tat gct gag acc acg tta gag        336
Gln Leu Ala Ser Thr Trp Ala Lys Ala Tyr Ala Glu Thr Thr Leu Glu           
            100                 105                 110                   

cat gca agg cct gaa gaa ccc agc tgg gat gaa gat ttt gca gat gtg        384
His Ala Arg Pro Glu Glu Pro Ser Trp Asp Glu Asp Phe Ala Asp Val           
        115                 120                 125                       

tac cat gac tta att cat tct cct gcc tct gaa act ctc tta aat ttg        432
Tyr His Asp Leu Ile His Ser Pro Ala Ser Glu Thr Leu Leu Asn Leu           
    130                 135                 140                           

gaa cat aat tac ttt gtt agt atc tca gaa ctg att ggt gaa aga gat        480
Glu His Asn Tyr Phe Val Ser Ile Ser Glu Leu Ile Gly Glu Arg Asp           
145                 150                 155                 160           

gtg gag ctg aaa aaa tta cga gag aga caa ggt att gaa atg gaa aaa        528
Val Glu Leu Lys Lys Leu Arg Glu Arg Gln Gly Ile Glu Met Glu Lys           
                165                 170                 175               

gtc atg cag gaa ttg gga aaa tca ctg aca gat caa gat gta aat tca        576
Val Met Gln Glu Leu Gly Lys Ser Leu Thr Asp Gln Asp Val Asn Ser           
            180                 185                 190                   

ctg gct gct cag cat ttt gaa tcc cag caa gac cta gaa aat aaa tgg        624
Leu Ala Ala Gln His Phe Glu Ser Gln Gln Asp Leu Glu Asn Lys Trp           
        195                 200                 205                       

tcg aat gaa tta aaa caa tca act gcc atc caa aaa caa gag tat caa        672
Ser Asn Glu Leu Lys Gln Ser Thr Ala Ile Gln Lys Gln Glu Tyr Gln           
    210                 215                 220                           

gaa tgg gta ata aaa ctt cac caa gac cta aaa aac ccc aac aac agc        720
Glu Trp Val Ile Lys Leu His Gln Asp Leu Lys Asn Pro Asn Asn Ser           
225                 230                 235                 240           

tcc ctt agt gag gaa att aaa gtt cag cca agt cag ttc aga gaa tct        768
Ser Leu Ser Glu Glu Ile Lys Val Gln Pro Ser Gln Phe Arg Glu Ser           
                245                 250                 255               

gta gaa gca att gga agg att tat gag gaa cag aga aag tta gaa gaa        816
Val Glu Ala Ile Gly Arg Ile Tyr Glu Glu Gln Arg Lys Leu Glu Glu           
            260                 265                 270                   

agt ttt acc att cac tta gga gcc cag ttg aag acc atg cat aat ttg        864
Ser Phe Thr Ile His Leu Gly Ala Gln Leu Lys Thr Met His Asn Leu           
        275                 280                 285                       

aga ttg ctg aga gca gat atg ctg gac ttc tgt aag cat aaa aga aat        912
Arg Leu Leu Arg Ala Asp Met Leu Asp Phe Cys Lys His Lys Arg Asn           
    290                 295                 300                           

cat cga agt ggt gtg aaa ctt cat cgg ctc caa aca gct ctg tca ctt        960
His Arg Ser Gly Val Lys Leu His Arg Leu Gln Thr Ala Leu Ser Leu           
305                 310                 315                 320           

tat tct aca tct ctc tgt ggc ctg gtt tta cta gta gat aat cga att       1008
Tyr Ser Thr Ser Leu Cys Gly Leu Val Leu Leu Val Asp Asn Arg Ile           
                325                 330                 335               

aat tca tat agt ggt att aaa aga gat ttt gcc aca gtt tgc caa gaa       1056
Asn Ser Tyr Ser Gly Ile Lys Arg Asp Phe Ala Thr Val Cys Gln Glu           
            340                 345                 350                   

tgc act gac ttc cat ttc ccc cga att gaa gag caa tta gaa gtt gtc       1104
Cys Thr Asp Phe His Phe Pro Arg Ile Glu Glu Gln Leu Glu Val Val           
        355                 360                 365                       

caa cag gtg gta ctt tat gct aga acc cag cgc agg agt aaa ttg aaa       1152
Gln Gln Val Val Leu Tyr Ala Arg Thr Gln Arg Arg Ser Lys Leu Lys           
    370                 375                 380                           

gaa tca ctt gat tct gga aac caa aat gga gga aat gat gat aag act       1200
Glu Ser Leu Asp Ser Gly Asn Gln Asn Gly Gly Asn Asp Asp Lys Thr           
385                 390                 395                 400           

aag aat gct gag agg aac tat tta aat gtt tta cct ggg gaa ttt tat       1248
Lys Asn Ala Glu Arg Asn Tyr Leu Asn Val Leu Pro Gly Glu Phe Tyr           
                405                 410                 415               

att aca cgg cat tct aat ctc tca gaa atc cat gtt gct ttc cat ctc       1296
Ile Thr Arg His Ser Asn Leu Ser Glu Ile His Val Ala Phe His Leu           
            420                 425                 430                   

tgt gtg gat gac cat gtg aaa tcg gga aac atc act gct cgt gat cct       1344
Cys Val Asp Asp His Val Lys Ser Gly Asn Ile Thr Ala Arg Asp Pro           
        435                 440                 445                       

gcc att atg gga ctc cga aat ata ctc aaa gtt tgc tgt acc cat gac       1392
Ala Ile Met Gly Leu Arg Asn Ile Leu Lys Val Cys Cys Thr His Asp           
    450                 455                 460                           

atc aca aca ata agc att cct ctc ttg ctg gta cat gat atg tca gag       1440
Ile Thr Thr Ile Ser Ile Pro Leu Leu Leu Val His Asp Met Ser Glu           
465                 470                 475                 480           

gaa atg act ata ccc tgg tgc tta agg aga gcg gaa ctt gtg ttc aag       1488
Glu Met Thr Ile Pro Trp Cys Leu Arg Arg Ala Glu Leu Val Phe Lys           
                485                 490                 495               

tgt gtc aaa ggt ttc atg atg gaa atg gct tca tgg gat gga gga att       1536
Cys Val Lys Gly Phe Met Met Glu Met Ala Ser Trp Asp Gly Gly Ile           
            500                 505                 510                   

tct agg aca gtg caa ttt cta gta cca cag agt att tct gaa gaa atg       1584
Ser Arg Thr Val Gln Phe Leu Val Pro Gln Ser Ile Ser Glu Glu Met           
        515                 520                 525                       

ttt tat caa ctt agt aac atg ctt ccc cag atc ttc cga gta tca tca       1632
Phe Tyr Gln Leu Ser Asn Met Leu Pro Gln Ile Phe Arg Val Ser Ser           
    530                 535                 540                           

aca ctc act ctg aca tcc aag cac taa                                   1659
Thr Leu Thr Leu Thr Ser Lys His                                           
545                 550                                                   


<210>  35
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Lys Lys Asn Arg Glu Arg Phe Cys Asn Arg Glu Arg Glu Phe Val 
1               5                   10                  15      


Tyr Lys Phe Lys Val Gly Ser Gln Cys Leu Glu Leu Arg Val Pro Leu 
            20                  25                  30          


Lys Phe Pro Val Gln Glu Asn Ala Ser His Leu His Gly Arg Leu Met 
        35                  40                  45              


Leu Leu His Ser Leu Pro Cys Phe Ile Glu Lys Asp Leu Lys Glu Ala 
    50                  55                  60                  


Leu Thr Gln Phe Ile Glu Glu Glu Ser Leu Ser Asp Tyr Asp Arg Asp 
65                  70                  75                  80  


Ala Glu Ala Ser Leu Ala Ala Val Lys Ser Gly Glu Val Asp Leu His 
                85                  90                  95      


Gln Leu Ala Ser Thr Trp Ala Lys Ala Tyr Ala Glu Thr Thr Leu Glu 
            100                 105                 110         


His Ala Arg Pro Glu Glu Pro Ser Trp Asp Glu Asp Phe Ala Asp Val 
        115                 120                 125             


Tyr His Asp Leu Ile His Ser Pro Ala Ser Glu Thr Leu Leu Asn Leu 
    130                 135                 140                 


Glu His Asn Tyr Phe Val Ser Ile Ser Glu Leu Ile Gly Glu Arg Asp 
145                 150                 155                 160 


Val Glu Leu Lys Lys Leu Arg Glu Arg Gln Gly Ile Glu Met Glu Lys 
                165                 170                 175     


Val Met Gln Glu Leu Gly Lys Ser Leu Thr Asp Gln Asp Val Asn Ser 
            180                 185                 190         


Leu Ala Ala Gln His Phe Glu Ser Gln Gln Asp Leu Glu Asn Lys Trp 
        195                 200                 205             


Ser Asn Glu Leu Lys Gln Ser Thr Ala Ile Gln Lys Gln Glu Tyr Gln 
    210                 215                 220                 


Glu Trp Val Ile Lys Leu His Gln Asp Leu Lys Asn Pro Asn Asn Ser 
225                 230                 235                 240 


Ser Leu Ser Glu Glu Ile Lys Val Gln Pro Ser Gln Phe Arg Glu Ser 
                245                 250                 255     


Val Glu Ala Ile Gly Arg Ile Tyr Glu Glu Gln Arg Lys Leu Glu Glu 
            260                 265                 270         


Ser Phe Thr Ile His Leu Gly Ala Gln Leu Lys Thr Met His Asn Leu 
        275                 280                 285             


Arg Leu Leu Arg Ala Asp Met Leu Asp Phe Cys Lys His Lys Arg Asn 
    290                 295                 300                 


His Arg Ser Gly Val Lys Leu His Arg Leu Gln Thr Ala Leu Ser Leu 
305                 310                 315                 320 


Tyr Ser Thr Ser Leu Cys Gly Leu Val Leu Leu Val Asp Asn Arg Ile 
                325                 330                 335     


Asn Ser Tyr Ser Gly Ile Lys Arg Asp Phe Ala Thr Val Cys Gln Glu 
            340                 345                 350         


Cys Thr Asp Phe His Phe Pro Arg Ile Glu Glu Gln Leu Glu Val Val 
        355                 360                 365             


Gln Gln Val Val Leu Tyr Ala Arg Thr Gln Arg Arg Ser Lys Leu Lys 
    370                 375                 380                 


Glu Ser Leu Asp Ser Gly Asn Gln Asn Gly Gly Asn Asp Asp Lys Thr 
385                 390                 395                 400 


Lys Asn Ala Glu Arg Asn Tyr Leu Asn Val Leu Pro Gly Glu Phe Tyr 
                405                 410                 415     


Ile Thr Arg His Ser Asn Leu Ser Glu Ile His Val Ala Phe His Leu 
            420                 425                 430         


Cys Val Asp Asp His Val Lys Ser Gly Asn Ile Thr Ala Arg Asp Pro 
        435                 440                 445             


Ala Ile Met Gly Leu Arg Asn Ile Leu Lys Val Cys Cys Thr His Asp 
    450                 455                 460                 


Ile Thr Thr Ile Ser Ile Pro Leu Leu Leu Val His Asp Met Ser Glu 
465                 470                 475                 480 


Glu Met Thr Ile Pro Trp Cys Leu Arg Arg Ala Glu Leu Val Phe Lys 
                485                 490                 495     


Cys Val Lys Gly Phe Met Met Glu Met Ala Ser Trp Asp Gly Gly Ile 
            500                 505                 510         


Ser Arg Thr Val Gln Phe Leu Val Pro Gln Ser Ile Ser Glu Glu Met 
        515                 520                 525             


Phe Tyr Gln Leu Ser Asn Met Leu Pro Gln Ile Phe Arg Val Ser Ser 
    530                 535                 540                 


Thr Leu Thr Leu Thr Ser Lys His 
545                 550         


<210>  36
<211>  1659
<212>  DNA
<213>  Macaca mulatta


<220>
<221>  CDS
<222>  (1)..(1659)
<223>  Protein LOC57102

<400>  36
atg aag aaa aac aga gaa aga ttc tgc aat aga gag aga gaa ttt gta         48
Met Lys Lys Asn Arg Glu Arg Phe Cys Asn Arg Glu Arg Glu Phe Val           
1               5                   10                  15                

tat aaa ttt aaa gta gga agt cag tgc tta gaa ctg aga gtg cca ctc         96
Tyr Lys Phe Lys Val Gly Ser Gln Cys Leu Glu Leu Arg Val Pro Leu           
            20                  25                  30                    

aga ttt cct gtt caa gag aat gcc agt cat tta cat gga cgt ctg atg        144
Arg Phe Pro Val Gln Glu Asn Ala Ser His Leu His Gly Arg Leu Met           
        35                  40                  45                        

ctg ctg cac agt tta ccg tgc ttt ata gaa aaa gac tta aaa gaa gct        192
Leu Leu His Ser Leu Pro Cys Phe Ile Glu Lys Asp Leu Lys Glu Ala           
    50                  55                  60                            

ctg act caa ttt ata gaa gaa gaa tcc ctc aga gat tat gat aga gat        240
Leu Thr Gln Phe Ile Glu Glu Glu Ser Leu Arg Asp Tyr Asp Arg Asp           
65                  70                  75                  80            

gct gaa gca tcc ctg gaa gct gtg aaa tca ggt gag gtg gat tta cat        288
Ala Glu Ala Ser Leu Glu Ala Val Lys Ser Gly Glu Val Asp Leu His           
                85                  90                  95                

cag ctg gcg agt acg tgg gcc aaa gct tat gcg gag acc aca tta gag        336
Gln Leu Ala Ser Thr Trp Ala Lys Ala Tyr Ala Glu Thr Thr Leu Glu           
            100                 105                 110                   

cat gcg agg cct gaa gaa ccc agc tgg gat gaa gat ttt gca gat gtg        384
His Ala Arg Pro Glu Glu Pro Ser Trp Asp Glu Asp Phe Ala Asp Val           
        115                 120                 125                       

tac cat gac cta att cat tct cct gcc tct gaa acg ctc tta aat ttg        432
Tyr His Asp Leu Ile His Ser Pro Ala Ser Glu Thr Leu Leu Asn Leu           
    130                 135                 140                           

gaa cat aat tac ttt gtt agt atc tca gaa ctg att ggt gag aga gat        480
Glu His Asn Tyr Phe Val Ser Ile Ser Glu Leu Ile Gly Glu Arg Asp           
145                 150                 155                 160           

gtg gaa ctg aaa aaa tta cga gag aga caa ggt att gaa atg gaa aaa        528
Val Glu Leu Lys Lys Leu Arg Glu Arg Gln Gly Ile Glu Met Glu Lys           
                165                 170                 175               

gta atg cag gag ttg gga aaa tca ctg aca gat caa gat gta aat tca        576
Val Met Gln Glu Leu Gly Lys Ser Leu Thr Asp Gln Asp Val Asn Ser           
            180                 185                 190                   

ctg gct gct cag cat ttt gaa tcc cag caa gac cta gaa aat aaa tgg        624
Leu Ala Ala Gln His Phe Glu Ser Gln Gln Asp Leu Glu Asn Lys Trp           
        195                 200                 205                       

tcg aat gaa tta aaa caa tca act gcc atc caa aaa caa gag tat cag        672
Ser Asn Glu Leu Lys Gln Ser Thr Ala Ile Gln Lys Gln Glu Tyr Gln           
    210                 215                 220                           

gaa tgg gta ata aaa ctt cac caa gac cta aaa aac ccc aac aac agc        720
Glu Trp Val Ile Lys Leu His Gln Asp Leu Lys Asn Pro Asn Asn Ser           
225                 230                 235                 240           

tcc ctt agt gag gaa att aaa gtt cag cca agt cag ttc aga gaa tct        768
Ser Leu Ser Glu Glu Ile Lys Val Gln Pro Ser Gln Phe Arg Glu Ser           
                245                 250                 255               

gta gaa gca att gga agg att tat gag gaa cag aga aag tta gaa gaa        816
Val Glu Ala Ile Gly Arg Ile Tyr Glu Glu Gln Arg Lys Leu Glu Glu           
            260                 265                 270                   

agt ttt acc att cac tta gga gcc cag tta aag acc atg cat aat ttg        864
Ser Phe Thr Ile His Leu Gly Ala Gln Leu Lys Thr Met His Asn Leu           
        275                 280                 285                       

aga ttg ctg aga gca gat atg ctg gac ttc tgt aag cat aaa aga aat        912
Arg Leu Leu Arg Ala Asp Met Leu Asp Phe Cys Lys His Lys Arg Asn           
    290                 295                 300                           

cat cga agt ggt gtg aaa ctt cat cgg ctc caa aca gct ctg tca ctt        960
His Arg Ser Gly Val Lys Leu His Arg Leu Gln Thr Ala Leu Ser Leu           
305                 310                 315                 320           

tat tct aca tct ctc tgt ggc ctg gtt tta cta gta gat aat cga att       1008
Tyr Ser Thr Ser Leu Cys Gly Leu Val Leu Leu Val Asp Asn Arg Ile           
                325                 330                 335               

aat tca tat agt ggt att aaa aga gat ttt gcc aca gtt tgc caa gaa       1056
Asn Ser Tyr Ser Gly Ile Lys Arg Asp Phe Ala Thr Val Cys Gln Glu           
            340                 345                 350                   

tgc act gac ttc cat ttt ccc cga att gaa gag caa tta gaa gtt gtc       1104
Cys Thr Asp Phe His Phe Pro Arg Ile Glu Glu Gln Leu Glu Val Val           
        355                 360                 365                       

caa cag gtg gta ctt tat gcc aga acc cag cgc agg agt aag ttg aaa       1152
Gln Gln Val Val Leu Tyr Ala Arg Thr Gln Arg Arg Ser Lys Leu Lys           
    370                 375                 380                           

gaa tca ctt gat tct ggg aac caa aat gga gga aat gat gat aag act       1200
Glu Ser Leu Asp Ser Gly Asn Gln Asn Gly Gly Asn Asp Asp Lys Thr           
385                 390                 395                 400           

aag aat gct gag agg aac tat tta aat gtt tta cct ggg gaa ttt tat       1248
Lys Asn Ala Glu Arg Asn Tyr Leu Asn Val Leu Pro Gly Glu Phe Tyr           
                405                 410                 415               

att aca cgg cat tcg aat ctc tca gaa atc cat gtt gct ttc cat ctt       1296
Ile Thr Arg His Ser Asn Leu Ser Glu Ile His Val Ala Phe His Leu           
            420                 425                 430                   

tgt gtg gat gac cat gtg aaa tcg gga aac atc act gct cgt gat cct       1344
Cys Val Asp Asp His Val Lys Ser Gly Asn Ile Thr Ala Arg Asp Pro           
        435                 440                 445                       

gcc att atg gga ctc cga aat ata ctc aaa gtt tgc tgt acc cat gac       1392
Ala Ile Met Gly Leu Arg Asn Ile Leu Lys Val Cys Cys Thr His Asp           
    450                 455                 460                           

atc aca aca ata agc att cct ctc ttg ctg gta cat gat atg tca gag       1440
Ile Thr Thr Ile Ser Ile Pro Leu Leu Leu Val His Asp Met Ser Glu           
465                 470                 475                 480           

gaa atg act ata ccc tgg tgc tta agg aga gca gaa cta gtg ttc aag       1488
Glu Met Thr Ile Pro Trp Cys Leu Arg Arg Ala Glu Leu Val Phe Lys           
                485                 490                 495               

tgt gtc aaa ggt ttc atg atg gaa atg gct tca tgg gat gga gga att       1536
Cys Val Lys Gly Phe Met Met Glu Met Ala Ser Trp Asp Gly Gly Ile           
            500                 505                 510                   

tct agg aca gtg cag ttt cta gta cca cag agt att tct gaa gaa atg       1584
Ser Arg Thr Val Gln Phe Leu Val Pro Gln Ser Ile Ser Glu Glu Met           
        515                 520                 525                       

ttt tat caa ctt agt aac atg ctt ccc cag att ttc cga gta tca tca       1632
Phe Tyr Gln Leu Ser Asn Met Leu Pro Gln Ile Phe Arg Val Ser Ser           
    530                 535                 540                           

aca ctc act ctg aca tcc aag cac taa                                   1659
Thr Leu Thr Leu Thr Ser Lys His                                           
545                 550                                                   


<210>  37
<211>  552
<212>  PRT
<213>  Macaca mulatta

<400>  37

Met Lys Lys Asn Arg Glu Arg Phe Cys Asn Arg Glu Arg Glu Phe Val 
1               5                   10                  15      


Tyr Lys Phe Lys Val Gly Ser Gln Cys Leu Glu Leu Arg Val Pro Leu 
            20                  25                  30          


Arg Phe Pro Val Gln Glu Asn Ala Ser His Leu His Gly Arg Leu Met 
        35                  40                  45              


Leu Leu His Ser Leu Pro Cys Phe Ile Glu Lys Asp Leu Lys Glu Ala 
    50                  55                  60                  


Leu Thr Gln Phe Ile Glu Glu Glu Ser Leu Arg Asp Tyr Asp Arg Asp 
65                  70                  75                  80  


Ala Glu Ala Ser Leu Glu Ala Val Lys Ser Gly Glu Val Asp Leu His 
                85                  90                  95      


Gln Leu Ala Ser Thr Trp Ala Lys Ala Tyr Ala Glu Thr Thr Leu Glu 
            100                 105                 110         


His Ala Arg Pro Glu Glu Pro Ser Trp Asp Glu Asp Phe Ala Asp Val 
        115                 120                 125             


Tyr His Asp Leu Ile His Ser Pro Ala Ser Glu Thr Leu Leu Asn Leu 
    130                 135                 140                 


Glu His Asn Tyr Phe Val Ser Ile Ser Glu Leu Ile Gly Glu Arg Asp 
145                 150                 155                 160 


Val Glu Leu Lys Lys Leu Arg Glu Arg Gln Gly Ile Glu Met Glu Lys 
                165                 170                 175     


Val Met Gln Glu Leu Gly Lys Ser Leu Thr Asp Gln Asp Val Asn Ser 
            180                 185                 190         


Leu Ala Ala Gln His Phe Glu Ser Gln Gln Asp Leu Glu Asn Lys Trp 
        195                 200                 205             


Ser Asn Glu Leu Lys Gln Ser Thr Ala Ile Gln Lys Gln Glu Tyr Gln 
    210                 215                 220                 


Glu Trp Val Ile Lys Leu His Gln Asp Leu Lys Asn Pro Asn Asn Ser 
225                 230                 235                 240 


Ser Leu Ser Glu Glu Ile Lys Val Gln Pro Ser Gln Phe Arg Glu Ser 
                245                 250                 255     


Val Glu Ala Ile Gly Arg Ile Tyr Glu Glu Gln Arg Lys Leu Glu Glu 
            260                 265                 270         


Ser Phe Thr Ile His Leu Gly Ala Gln Leu Lys Thr Met His Asn Leu 
        275                 280                 285             


Arg Leu Leu Arg Ala Asp Met Leu Asp Phe Cys Lys His Lys Arg Asn 
    290                 295                 300                 


His Arg Ser Gly Val Lys Leu His Arg Leu Gln Thr Ala Leu Ser Leu 
305                 310                 315                 320 


Tyr Ser Thr Ser Leu Cys Gly Leu Val Leu Leu Val Asp Asn Arg Ile 
                325                 330                 335     


Asn Ser Tyr Ser Gly Ile Lys Arg Asp Phe Ala Thr Val Cys Gln Glu 
            340                 345                 350         


Cys Thr Asp Phe His Phe Pro Arg Ile Glu Glu Gln Leu Glu Val Val 
        355                 360                 365             


Gln Gln Val Val Leu Tyr Ala Arg Thr Gln Arg Arg Ser Lys Leu Lys 
    370                 375                 380                 


Glu Ser Leu Asp Ser Gly Asn Gln Asn Gly Gly Asn Asp Asp Lys Thr 
385                 390                 395                 400 


Lys Asn Ala Glu Arg Asn Tyr Leu Asn Val Leu Pro Gly Glu Phe Tyr 
                405                 410                 415     


Ile Thr Arg His Ser Asn Leu Ser Glu Ile His Val Ala Phe His Leu 
            420                 425                 430         


Cys Val Asp Asp His Val Lys Ser Gly Asn Ile Thr Ala Arg Asp Pro 
        435                 440                 445             


Ala Ile Met Gly Leu Arg Asn Ile Leu Lys Val Cys Cys Thr His Asp 
    450                 455                 460                 


Ile Thr Thr Ile Ser Ile Pro Leu Leu Leu Val His Asp Met Ser Glu 
465                 470                 475                 480 


Glu Met Thr Ile Pro Trp Cys Leu Arg Arg Ala Glu Leu Val Phe Lys 
                485                 490                 495     


Cys Val Lys Gly Phe Met Met Glu Met Ala Ser Trp Asp Gly Gly Ile 
            500                 505                 510         


Ser Arg Thr Val Gln Phe Leu Val Pro Gln Ser Ile Ser Glu Glu Met 
        515                 520                 525             


Phe Tyr Gln Leu Ser Asn Met Leu Pro Gln Ile Phe Arg Val Ser Ser 
    530                 535                 540                 


Thr Leu Thr Leu Thr Ser Lys His 
545                 550         


<210>  38
<211>  1659
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(1659)
<223>  Protein LOC28040

<400>  38
atg aag aaa aac cga gaa agg ttc tgc aac aag gaa agg gaa ttt gtg         48
Met Lys Lys Asn Arg Glu Arg Phe Cys Asn Lys Glu Arg Glu Phe Val           
1               5                   10                  15                

tac aag ttc cag gta gga cgt gag cgc tta gag ctg aga gtg ccc ctc         96
Tyr Lys Phe Gln Val Gly Arg Glu Arg Leu Glu Leu Arg Val Pro Leu           
            20                  25                  30                    

agg ttt cct gtg gag gag aat gcc agt cat ctg cat gga cgt ctg atg        144
Arg Phe Pro Val Glu Glu Asn Ala Ser His Leu His Gly Arg Leu Met           
        35                  40                  45                        

ctg ctg cac agc ttg cct tgc ttc ata gag agt gac tta aaa gat gct        192
Leu Leu His Ser Leu Pro Cys Phe Ile Glu Ser Asp Leu Lys Asp Ala           
    50                  55                  60                            

ctg agc cgg ttt ata gaa gaa gaa tcc ctc aga gac cat gac agc gat        240
Leu Ser Arg Phe Ile Glu Glu Glu Ser Leu Arg Asp His Asp Ser Asp           
65                  70                  75                  80            

gca gaa gca tgc ttg gag gcc gtt aaa tcc ggt gaa gta gat ctg cac        288
Ala Glu Ala Cys Leu Glu Ala Val Lys Ser Gly Glu Val Asp Leu His           
                85                  90                  95                

cag ctg gca agt gcg tgg gcc aaa gct tac gct gag acc acc tta gag        336
Gln Leu Ala Ser Ala Trp Ala Lys Ala Tyr Ala Glu Thr Thr Leu Glu           
            100                 105                 110                   

cat gcg aga cct gag gag cct gac tgg gac gaa gac ttt gca gat gtg        384
His Ala Arg Pro Glu Glu Pro Asp Trp Asp Glu Asp Phe Ala Asp Val           
        115                 120                 125                       

tac cat gac cta atc cac tcc ccg gcc tct gaa act ctc tta aat ctg        432
Tyr His Asp Leu Ile His Ser Pro Ala Ser Glu Thr Leu Leu Asn Leu           
    130                 135                 140                           

gaa cac aac tac ttc gtt agc atc tca gag ctg att ggt gaa aga gac        480
Glu His Asn Tyr Phe Val Ser Ile Ser Glu Leu Ile Gly Glu Arg Asp           
145                 150                 155                 160           

gtg gag ctg aaa aag tta cga gag aga caa ggt att gaa atg gaa aag        528
Val Glu Leu Lys Lys Leu Arg Glu Arg Gln Gly Ile Glu Met Glu Lys           
                165                 170                 175               

gtg atg cag gag ctg ggg aaa tcg ctc aca gat caa gat gtg aat tca        576
Val Met Gln Glu Leu Gly Lys Ser Leu Thr Asp Gln Asp Val Asn Ser           
            180                 185                 190                   

ctg gct gcc cag cac ttt gaa tcc cag caa gac tta gag aat aaa tgg        624
Leu Ala Ala Gln His Phe Glu Ser Gln Gln Asp Leu Glu Asn Lys Trp           
        195                 200                 205                       

tca aat gaa ctg aaa cag tct aca gct atc cag aag caa gaa tat cag        672
Ser Asn Glu Leu Lys Gln Ser Thr Ala Ile Gln Lys Gln Glu Tyr Gln           
    210                 215                 220                           

gaa tgg gtg ata aag ctt cat cag gac cta aaa aac ccc aac aac agc        720
Glu Trp Val Ile Lys Leu His Gln Asp Leu Lys Asn Pro Asn Asn Ser           
225                 230                 235                 240           

tcc ctc agt gaa gag att aaa gtg cag ccg agt cag ttc aga gag tct        768
Ser Leu Ser Glu Glu Ile Lys Val Gln Pro Ser Gln Phe Arg Glu Ser           
                245                 250                 255               

gcg gac gct gct ggg agg atc tac gag gaa cag agg aag ctg gag gag        816
Ala Asp Ala Ala Gly Arg Ile Tyr Glu Glu Gln Arg Lys Leu Glu Glu           
            260                 265                 270                   

agc ttc acc att cac ctg gga gcc cag ttg aag acc atg cac aac ctg        864
Ser Phe Thr Ile His Leu Gly Ala Gln Leu Lys Thr Met His Asn Leu           
        275                 280                 285                       

cgg ctg ctg agg gca gac atg ctg gac ttc tgt aag cat aag aga act        912
Arg Leu Leu Arg Ala Asp Met Leu Asp Phe Cys Lys His Lys Arg Thr           
    290                 295                 300                           

cac ggg agc ggc gtg aag ctc cac cgt ctg cag aca gca ctg tcc ctc        960
His Gly Ser Gly Val Lys Leu His Arg Leu Gln Thr Ala Leu Ser Leu           
305                 310                 315                 320           

tac tcc acg tct ctc tgt ggc ctg gtt ttg cta gta gat aat cga att       1008
Tyr Ser Thr Ser Leu Cys Gly Leu Val Leu Leu Val Asp Asn Arg Ile           
                325                 330                 335               

aat tca tat agc ggc atc aaa aga gat ttt gcc aca gtt tgc caa gaa       1056
Asn Ser Tyr Ser Gly Ile Lys Arg Asp Phe Ala Thr Val Cys Gln Glu           
            340                 345                 350                   

tgt acg gac ttc cac ttc cca cgg att gag gaa caa ctg gaa gtt gtc       1104
Cys Thr Asp Phe His Phe Pro Arg Ile Glu Glu Gln Leu Glu Val Val           
        355                 360                 365                       

cag cag gtg gcg ctg tac gcg aga acc caa cgc aag agc aag tgc aaa       1152
Gln Gln Val Ala Leu Tyr Ala Arg Thr Gln Arg Lys Ser Lys Cys Lys           
    370                 375                 380                           

gag gcc cgc gat tct gga aac caa aat gga gga agt gat gat aag tct       1200
Glu Ala Arg Asp Ser Gly Asn Gln Asn Gly Gly Ser Asp Asp Lys Ser           
385                 390                 395                 400           

aag aat gct gag aga aac tat tta aat att tta cct gga gaa ttt tac       1248
Lys Asn Ala Glu Arg Asn Tyr Leu Asn Ile Leu Pro Gly Glu Phe Tyr           
                405                 410                 415               

att aca cgt cat tct aat ctc tcg gaa atc cat gtt gct ttc cac ctc       1296
Ile Thr Arg His Ser Asn Leu Ser Glu Ile His Val Ala Phe His Leu           
            420                 425                 430                   

tgt gtg gat gat aac gtg aag tcg gga aat atc act gct cgg gat ccc       1344
Cys Val Asp Asp Asn Val Lys Ser Gly Asn Ile Thr Ala Arg Asp Pro           
        435                 440                 445                       

gct att atg gga ctc cga aac att ctc aaa gtc tgc tgt acc cat gat       1392
Ala Ile Met Gly Leu Arg Asn Ile Leu Lys Val Cys Cys Thr His Asp           
    450                 455                 460                           

atc aca acg ata agc atc cct ctc ttg ctg gtg cat gat atg tca gag       1440
Ile Thr Thr Ile Ser Ile Pro Leu Leu Leu Val His Asp Met Ser Glu           
465                 470                 475                 480           

gaa atg act ata cct tgg tgt tta agg aga gca gaa ctg gta ttt aag       1488
Glu Met Thr Ile Pro Trp Cys Leu Arg Arg Ala Glu Leu Val Phe Lys           
                485                 490                 495               

tgt gtc aaa ggt ttc atg atg gag atg gct tca tgg gac gga gga att       1536
Cys Val Lys Gly Phe Met Met Glu Met Ala Ser Trp Asp Gly Gly Ile           
            500                 505                 510                   

tct cgg aca gtg caa ttt ctg gta cca cag agc att tct gaa gaa atg       1584
Ser Arg Thr Val Gln Phe Leu Val Pro Gln Ser Ile Ser Glu Glu Met           
        515                 520                 525                       

ttt tat cag ctg agc aac atg ctt ccc cag atc ttc cgg gtc tcc tca       1632
Phe Tyr Gln Leu Ser Asn Met Leu Pro Gln Ile Phe Arg Val Ser Ser           
    530                 535                 540                           

aca ctc acg ctg aca tcc aag cac taa                                   1659
Thr Leu Thr Leu Thr Ser Lys His                                           
545                 550                                                   


<210>  39
<211>  552
<212>  PRT
<213>  Mus musculus

<400>  39

Met Lys Lys Asn Arg Glu Arg Phe Cys Asn Lys Glu Arg Glu Phe Val 
1               5                   10                  15      


Tyr Lys Phe Gln Val Gly Arg Glu Arg Leu Glu Leu Arg Val Pro Leu 
            20                  25                  30          


Arg Phe Pro Val Glu Glu Asn Ala Ser His Leu His Gly Arg Leu Met 
        35                  40                  45              


Leu Leu His Ser Leu Pro Cys Phe Ile Glu Ser Asp Leu Lys Asp Ala 
    50                  55                  60                  


Leu Ser Arg Phe Ile Glu Glu Glu Ser Leu Arg Asp His Asp Ser Asp 
65                  70                  75                  80  


Ala Glu Ala Cys Leu Glu Ala Val Lys Ser Gly Glu Val Asp Leu His 
                85                  90                  95      


Gln Leu Ala Ser Ala Trp Ala Lys Ala Tyr Ala Glu Thr Thr Leu Glu 
            100                 105                 110         


His Ala Arg Pro Glu Glu Pro Asp Trp Asp Glu Asp Phe Ala Asp Val 
        115                 120                 125             


Tyr His Asp Leu Ile His Ser Pro Ala Ser Glu Thr Leu Leu Asn Leu 
    130                 135                 140                 


Glu His Asn Tyr Phe Val Ser Ile Ser Glu Leu Ile Gly Glu Arg Asp 
145                 150                 155                 160 


Val Glu Leu Lys Lys Leu Arg Glu Arg Gln Gly Ile Glu Met Glu Lys 
                165                 170                 175     


Val Met Gln Glu Leu Gly Lys Ser Leu Thr Asp Gln Asp Val Asn Ser 
            180                 185                 190         


Leu Ala Ala Gln His Phe Glu Ser Gln Gln Asp Leu Glu Asn Lys Trp 
        195                 200                 205             


Ser Asn Glu Leu Lys Gln Ser Thr Ala Ile Gln Lys Gln Glu Tyr Gln 
    210                 215                 220                 


Glu Trp Val Ile Lys Leu His Gln Asp Leu Lys Asn Pro Asn Asn Ser 
225                 230                 235                 240 


Ser Leu Ser Glu Glu Ile Lys Val Gln Pro Ser Gln Phe Arg Glu Ser 
                245                 250                 255     


Ala Asp Ala Ala Gly Arg Ile Tyr Glu Glu Gln Arg Lys Leu Glu Glu 
            260                 265                 270         


Ser Phe Thr Ile His Leu Gly Ala Gln Leu Lys Thr Met His Asn Leu 
        275                 280                 285             


Arg Leu Leu Arg Ala Asp Met Leu Asp Phe Cys Lys His Lys Arg Thr 
    290                 295                 300                 


His Gly Ser Gly Val Lys Leu His Arg Leu Gln Thr Ala Leu Ser Leu 
305                 310                 315                 320 


Tyr Ser Thr Ser Leu Cys Gly Leu Val Leu Leu Val Asp Asn Arg Ile 
                325                 330                 335     


Asn Ser Tyr Ser Gly Ile Lys Arg Asp Phe Ala Thr Val Cys Gln Glu 
            340                 345                 350         


Cys Thr Asp Phe His Phe Pro Arg Ile Glu Glu Gln Leu Glu Val Val 
        355                 360                 365             


Gln Gln Val Ala Leu Tyr Ala Arg Thr Gln Arg Lys Ser Lys Cys Lys 
    370                 375                 380                 


Glu Ala Arg Asp Ser Gly Asn Gln Asn Gly Gly Ser Asp Asp Lys Ser 
385                 390                 395                 400 


Lys Asn Ala Glu Arg Asn Tyr Leu Asn Ile Leu Pro Gly Glu Phe Tyr 
                405                 410                 415     


Ile Thr Arg His Ser Asn Leu Ser Glu Ile His Val Ala Phe His Leu 
            420                 425                 430         


Cys Val Asp Asp Asn Val Lys Ser Gly Asn Ile Thr Ala Arg Asp Pro 
        435                 440                 445             


Ala Ile Met Gly Leu Arg Asn Ile Leu Lys Val Cys Cys Thr His Asp 
    450                 455                 460                 


Ile Thr Thr Ile Ser Ile Pro Leu Leu Leu Val His Asp Met Ser Glu 
465                 470                 475                 480 


Glu Met Thr Ile Pro Trp Cys Leu Arg Arg Ala Glu Leu Val Phe Lys 
                485                 490                 495     


Cys Val Lys Gly Phe Met Met Glu Met Ala Ser Trp Asp Gly Gly Ile 
            500                 505                 510         


Ser Arg Thr Val Gln Phe Leu Val Pro Gln Ser Ile Ser Glu Glu Met 
        515                 520                 525             


Phe Tyr Gln Leu Ser Asn Met Leu Pro Gln Ile Phe Arg Val Ser Ser 
    530                 535                 540                 


Thr Leu Thr Leu Thr Ser Lys His 
545                 550         


<210>  40
<211>  2538
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(2538)
<223>  ABCF1 Protein

<400>  40
atg ccg aag gcg ccc aag cag cag ccg ccg gag ccc gag tgg atc ggg         48
Met Pro Lys Ala Pro Lys Gln Gln Pro Pro Glu Pro Glu Trp Ile Gly           
1               5                   10                  15                

gac gga gag agc acg agc cca tca gac aaa gtg gtg aag aaa ggg aag         96
Asp Gly Glu Ser Thr Ser Pro Ser Asp Lys Val Val Lys Lys Gly Lys           
            20                  25                  30                    

aag gac aag aag atc aaa aaa acg ttc ttt gaa gag ctg gca gta gaa        144
Lys Asp Lys Lys Ile Lys Lys Thr Phe Phe Glu Glu Leu Ala Val Glu           
        35                  40                  45                        

gat aaa cag gct ggg gaa gaa gag aaa gtg ctc aag gag aag gag cag        192
Asp Lys Gln Ala Gly Glu Glu Glu Lys Val Leu Lys Glu Lys Glu Gln           
    50                  55                  60                            

cag cag cag caa cag caa cag cag caa aaa aaa aag cga gat acc cga        240
Gln Gln Gln Gln Gln Gln Gln Gln Gln Lys Lys Lys Arg Asp Thr Arg           
65                  70                  75                  80            

aaa ggc agg cgg aag aag gat gtg gat gat gat gga gaa gag aaa gag        288
Lys Gly Arg Arg Lys Lys Asp Val Asp Asp Asp Gly Glu Glu Lys Glu           
                85                  90                  95                

ctc atg gag cgt ctt aag aag ctc tca gtg cca acc agt gat gag gag        336
Leu Met Glu Arg Leu Lys Lys Leu Ser Val Pro Thr Ser Asp Glu Glu           
            100                 105                 110                   

gat gaa gta ccc gcc cca aaa ccc cgc gga ggg aag aaa acc aag ggt        384
Asp Glu Val Pro Ala Pro Lys Pro Arg Gly Gly Lys Lys Thr Lys Gly           
        115                 120                 125                       

ggt aat gtt ttt gca gcc ctg att cag gat cag agt gag gaa gag gag        432
Gly Asn Val Phe Ala Ala Leu Ile Gln Asp Gln Ser Glu Glu Glu Glu           
    130                 135                 140                           

gag gaa gaa aaa cat cct cct aag cct gcc aag ccg gag aag aat cgg        480
Glu Glu Glu Lys His Pro Pro Lys Pro Ala Lys Pro Glu Lys Asn Arg           
145                 150                 155                 160           

atc aat aag gcc gta tct gag gaa cag cag cct gca ctc aag ggc aaa        528
Ile Asn Lys Ala Val Ser Glu Glu Gln Gln Pro Ala Leu Lys Gly Lys           
                165                 170                 175               

aag gga aag gaa gag aag tca aaa ggg aag gct aag cct caa aat aaa        576
Lys Gly Lys Glu Glu Lys Ser Lys Gly Lys Ala Lys Pro Gln Asn Lys           
            180                 185                 190                   

ttc gct gct ctg gac aat gaa gag gag gat aaa gaa gaa gaa att ata        624
Phe Ala Ala Leu Asp Asn Glu Glu Glu Asp Lys Glu Glu Glu Ile Ile           
        195                 200                 205                       

aag gaa aag gag cct ccc aaa caa ggg aag gag aag gcc aag aag gca        672
Lys Glu Lys Glu Pro Pro Lys Gln Gly Lys Glu Lys Ala Lys Lys Ala           
    210                 215                 220                           

gag cag ggt tca gag gaa gaa gga gaa ggg gaa gaa gag gag gag gaa        720
Glu Gln Gly Ser Glu Glu Glu Gly Glu Gly Glu Glu Glu Glu Glu Glu           
225                 230                 235                 240           

gga gga gag tct aag gca gat gat ccc tat gct cat ctt agc aaa aag        768
Gly Gly Glu Ser Lys Ala Asp Asp Pro Tyr Ala His Leu Ser Lys Lys           
                245                 250                 255               

gag aag aaa aag ctg aaa aaa cag atg gag tat gag cgc caa gtg gct        816
Glu Lys Lys Lys Leu Lys Lys Gln Met Glu Tyr Glu Arg Gln Val Ala           
            260                 265                 270                   

tca tta aaa gca gcc aat gca gct gaa aat gac ttc tcc gtg tcc cag        864
Ser Leu Lys Ala Ala Asn Ala Ala Glu Asn Asp Phe Ser Val Ser Gln           
        275                 280                 285                       

gcg gag atg tcc tcc cgc caa gcc atg tta gaa aat gca tct gac atc        912
Ala Glu Met Ser Ser Arg Gln Ala Met Leu Glu Asn Ala Ser Asp Ile           
    290                 295                 300                           

aag ctg gag aag ttc agc atc tcc gct cat ggc aag gag ctg ttc gtc        960
Lys Leu Glu Lys Phe Ser Ile Ser Ala His Gly Lys Glu Leu Phe Val           
305                 310                 315                 320           

aat gca gac ctg tac att gta gcc ggc cgc cgc tac ggg ctg gta gga       1008
Asn Ala Asp Leu Tyr Ile Val Ala Gly Arg Arg Tyr Gly Leu Val Gly           
                325                 330                 335               

ccc aat ggc aag ggc aag acc aca ctc ctc aag cac att gcc aac cga       1056
Pro Asn Gly Lys Gly Lys Thr Thr Leu Leu Lys His Ile Ala Asn Arg           
            340                 345                 350                   

gcc ctg agc atc cct ccc aac att gat gtg ttg ctg tgt gag cag gag       1104
Ala Leu Ser Ile Pro Pro Asn Ile Asp Val Leu Leu Cys Glu Gln Glu           
        355                 360                 365                       

gtg gta gca gat gag aca cca gca gtc cag gct gtt ctt cga gct gac       1152
Val Val Ala Asp Glu Thr Pro Ala Val Gln Ala Val Leu Arg Ala Asp           
    370                 375                 380                           

acc aag cga ttg aag ctg ctg gaa gag gag cgg cgg ctt cag gga cag       1200
Thr Lys Arg Leu Lys Leu Leu Glu Glu Glu Arg Arg Leu Gln Gly Gln           
385                 390                 395                 400           

ctg gaa caa ggg gat gac aca gct gct gag agg cta gag aag gtg tat       1248
Leu Glu Gln Gly Asp Asp Thr Ala Ala Glu Arg Leu Glu Lys Val Tyr           
                405                 410                 415               

gag gaa ttg cgg gcc act ggg gcg gca gct gca gag gcc aaa gca cgg       1296
Glu Glu Leu Arg Ala Thr Gly Ala Ala Ala Ala Glu Ala Lys Ala Arg           
            420                 425                 430                   

cgg atc ctg gct ggc ctg ggc ttt gac cct gaa atg cag aat cga ccc       1344
Arg Ile Leu Ala Gly Leu Gly Phe Asp Pro Glu Met Gln Asn Arg Pro           
        435                 440                 445                       

aca cag aag ttc tca ggg ggc tgg cgc atg cgt gtc tcc ctg gcc agg       1392
Thr Gln Lys Phe Ser Gly Gly Trp Arg Met Arg Val Ser Leu Ala Arg           
    450                 455                 460                           

gca ctg ttc atg gag ccc aca ctg ctg atg ctg gat gag ccc acc aac       1440
Ala Leu Phe Met Glu Pro Thr Leu Leu Met Leu Asp Glu Pro Thr Asn           
465                 470                 475                 480           

cac ctg gac ctc aac gct gtc atc tgg ctt aat aac tac ctc cag ggc       1488
His Leu Asp Leu Asn Ala Val Ile Trp Leu Asn Asn Tyr Leu Gln Gly           
                485                 490                 495               

tgg cgg aag acc ttg ctg atc gtc tcc cat gac cag ggc ttc ttg gat       1536
Trp Arg Lys Thr Leu Leu Ile Val Ser His Asp Gln Gly Phe Leu Asp           
            500                 505                 510                   

gat gtc tgc act gat atc atc cac ctc gat gcc cag cgg ctc cac tac       1584
Asp Val Cys Thr Asp Ile Ile His Leu Asp Ala Gln Arg Leu His Tyr           
        515                 520                 525                       

tat agg ggc aat tac atg acc ttc aaa aag atg tac cag cag aag cag       1632
Tyr Arg Gly Asn Tyr Met Thr Phe Lys Lys Met Tyr Gln Gln Lys Gln           
    530                 535                 540                           

aaa gaa ctg ctg aaa cag tat gag aag caa gag aaa aag ctg aag gag       1680
Lys Glu Leu Leu Lys Gln Tyr Glu Lys Gln Glu Lys Lys Leu Lys Glu           
545                 550                 555                 560           

ctg aag gca ggc ggg aag tcc acc aag cag gcg gaa aaa caa acg aag       1728
Leu Lys Ala Gly Gly Lys Ser Thr Lys Gln Ala Glu Lys Gln Thr Lys           
                565                 570                 575               

gaa gcc ctg act cgg aag cag cag aaa tgc cga cgg aaa aac caa gat       1776
Glu Ala Leu Thr Arg Lys Gln Gln Lys Cys Arg Arg Lys Asn Gln Asp           
            580                 585                 590                   

gag gaa tcc cag gag gcc cct gag ctc ctg aag cgc cct aag gag tac       1824
Glu Glu Ser Gln Glu Ala Pro Glu Leu Leu Lys Arg Pro Lys Glu Tyr           
        595                 600                 605                       

act gtg cgc ttc act ttt cca gac ccc cca cca ctc agc cct cca gtg       1872
Thr Val Arg Phe Thr Phe Pro Asp Pro Pro Pro Leu Ser Pro Pro Val           
    610                 615                 620                           

ctg ggt ctg cat ggt gtg aca ttc ggc tac cag gga cag aaa cca ctc       1920
Leu Gly Leu His Gly Val Thr Phe Gly Tyr Gln Gly Gln Lys Pro Leu           
625                 630                 635                 640           

ttt aag aac ttg gat ttt ggc atc gac atg gat tca agg att tgc att       1968
Phe Lys Asn Leu Asp Phe Gly Ile Asp Met Asp Ser Arg Ile Cys Ile           
                645                 650                 655               

gtg ggc cct aat ggt gtg ggg aag agt acg cta ctc ctg ctg ctg act       2016
Val Gly Pro Asn Gly Val Gly Lys Ser Thr Leu Leu Leu Leu Leu Thr           
            660                 665                 670                   

ggc aag ctg aca ccg acc cat ggg gaa atg aga aag aac cac cgg ctg       2064
Gly Lys Leu Thr Pro Thr His Gly Glu Met Arg Lys Asn His Arg Leu           
        675                 680                 685                       

aaa att ggc ttc ttc aac cag cag tat gca gag cag ctg cgc atg gag       2112
Lys Ile Gly Phe Phe Asn Gln Gln Tyr Ala Glu Gln Leu Arg Met Glu           
    690                 695                 700                           

gag acg ccc act gag tac ctg cag cgg ggc ttc aac ctg ccc tac cag       2160
Glu Thr Pro Thr Glu Tyr Leu Gln Arg Gly Phe Asn Leu Pro Tyr Gln           
705                 710                 715                 720           

gat gcc cgc aag tgc ctg ggc cgc ttc ggc ctg gag agt cac gcc cac       2208
Asp Ala Arg Lys Cys Leu Gly Arg Phe Gly Leu Glu Ser His Ala His           
                725                 730                 735               

acc atc cag atc tgc aaa ctc tct ggt ggt cag aag gcg cga gtt gtg       2256
Thr Ile Gln Ile Cys Lys Leu Ser Gly Gly Gln Lys Ala Arg Val Val           
            740                 745                 750                   

ttt gct gag ctg gcc tgt cgg gaa cct gat gtc ctc atc ttg gac gag       2304
Phe Ala Glu Leu Ala Cys Arg Glu Pro Asp Val Leu Ile Leu Asp Glu           
        755                 760                 765                       

cca acc aat aac ctg gac ata gag tct att gat gct cta ggg gag gcc       2352
Pro Thr Asn Asn Leu Asp Ile Glu Ser Ile Asp Ala Leu Gly Glu Ala           
    770                 775                 780                           

atc aat gaa tac aag ggt gct gtg atc gtt gtc agc cat gat gcc cga       2400
Ile Asn Glu Tyr Lys Gly Ala Val Ile Val Val Ser His Asp Ala Arg           
785                 790                 795                 800           

ctc atc aca gaa acc aat tgc cag ctg tgg gtg gtg gag gag cag agt       2448
Leu Ile Thr Glu Thr Asn Cys Gln Leu Trp Val Val Glu Glu Gln Ser           
                805                 810                 815               

gtt agc caa atc gat ggt gac ttt gaa gac tac aag cgg gag gtg ttg       2496
Val Ser Gln Ile Asp Gly Asp Phe Glu Asp Tyr Lys Arg Glu Val Leu           
            820                 825                 830                   

gag gcc ctg ggt gaa gtc atg gtc agc cgg ccc cga gag tga               2538
Glu Ala Leu Gly Glu Val Met Val Ser Arg Pro Arg Glu                       
        835                 840                 845                       


<210>  41
<211>  845
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Pro Lys Ala Pro Lys Gln Gln Pro Pro Glu Pro Glu Trp Ile Gly 
1               5                   10                  15      


Asp Gly Glu Ser Thr Ser Pro Ser Asp Lys Val Val Lys Lys Gly Lys 
            20                  25                  30          


Lys Asp Lys Lys Ile Lys Lys Thr Phe Phe Glu Glu Leu Ala Val Glu 
        35                  40                  45              


Asp Lys Gln Ala Gly Glu Glu Glu Lys Val Leu Lys Glu Lys Glu Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Lys Lys Lys Arg Asp Thr Arg 
65                  70                  75                  80  


Lys Gly Arg Arg Lys Lys Asp Val Asp Asp Asp Gly Glu Glu Lys Glu 
                85                  90                  95      


Leu Met Glu Arg Leu Lys Lys Leu Ser Val Pro Thr Ser Asp Glu Glu 
            100                 105                 110         


Asp Glu Val Pro Ala Pro Lys Pro Arg Gly Gly Lys Lys Thr Lys Gly 
        115                 120                 125             


Gly Asn Val Phe Ala Ala Leu Ile Gln Asp Gln Ser Glu Glu Glu Glu 
    130                 135                 140                 


Glu Glu Glu Lys His Pro Pro Lys Pro Ala Lys Pro Glu Lys Asn Arg 
145                 150                 155                 160 


Ile Asn Lys Ala Val Ser Glu Glu Gln Gln Pro Ala Leu Lys Gly Lys 
                165                 170                 175     


Lys Gly Lys Glu Glu Lys Ser Lys Gly Lys Ala Lys Pro Gln Asn Lys 
            180                 185                 190         


Phe Ala Ala Leu Asp Asn Glu Glu Glu Asp Lys Glu Glu Glu Ile Ile 
        195                 200                 205             


Lys Glu Lys Glu Pro Pro Lys Gln Gly Lys Glu Lys Ala Lys Lys Ala 
    210                 215                 220                 


Glu Gln Gly Ser Glu Glu Glu Gly Glu Gly Glu Glu Glu Glu Glu Glu 
225                 230                 235                 240 


Gly Gly Glu Ser Lys Ala Asp Asp Pro Tyr Ala His Leu Ser Lys Lys 
                245                 250                 255     


Glu Lys Lys Lys Leu Lys Lys Gln Met Glu Tyr Glu Arg Gln Val Ala 
            260                 265                 270         


Ser Leu Lys Ala Ala Asn Ala Ala Glu Asn Asp Phe Ser Val Ser Gln 
        275                 280                 285             


Ala Glu Met Ser Ser Arg Gln Ala Met Leu Glu Asn Ala Ser Asp Ile 
    290                 295                 300                 


Lys Leu Glu Lys Phe Ser Ile Ser Ala His Gly Lys Glu Leu Phe Val 
305                 310                 315                 320 


Asn Ala Asp Leu Tyr Ile Val Ala Gly Arg Arg Tyr Gly Leu Val Gly 
                325                 330                 335     


Pro Asn Gly Lys Gly Lys Thr Thr Leu Leu Lys His Ile Ala Asn Arg 
            340                 345                 350         


Ala Leu Ser Ile Pro Pro Asn Ile Asp Val Leu Leu Cys Glu Gln Glu 
        355                 360                 365             


Val Val Ala Asp Glu Thr Pro Ala Val Gln Ala Val Leu Arg Ala Asp 
    370                 375                 380                 


Thr Lys Arg Leu Lys Leu Leu Glu Glu Glu Arg Arg Leu Gln Gly Gln 
385                 390                 395                 400 


Leu Glu Gln Gly Asp Asp Thr Ala Ala Glu Arg Leu Glu Lys Val Tyr 
                405                 410                 415     


Glu Glu Leu Arg Ala Thr Gly Ala Ala Ala Ala Glu Ala Lys Ala Arg 
            420                 425                 430         


Arg Ile Leu Ala Gly Leu Gly Phe Asp Pro Glu Met Gln Asn Arg Pro 
        435                 440                 445             


Thr Gln Lys Phe Ser Gly Gly Trp Arg Met Arg Val Ser Leu Ala Arg 
    450                 455                 460                 


Ala Leu Phe Met Glu Pro Thr Leu Leu Met Leu Asp Glu Pro Thr Asn 
465                 470                 475                 480 


His Leu Asp Leu Asn Ala Val Ile Trp Leu Asn Asn Tyr Leu Gln Gly 
                485                 490                 495     


Trp Arg Lys Thr Leu Leu Ile Val Ser His Asp Gln Gly Phe Leu Asp 
            500                 505                 510         


Asp Val Cys Thr Asp Ile Ile His Leu Asp Ala Gln Arg Leu His Tyr 
        515                 520                 525             


Tyr Arg Gly Asn Tyr Met Thr Phe Lys Lys Met Tyr Gln Gln Lys Gln 
    530                 535                 540                 


Lys Glu Leu Leu Lys Gln Tyr Glu Lys Gln Glu Lys Lys Leu Lys Glu 
545                 550                 555                 560 


Leu Lys Ala Gly Gly Lys Ser Thr Lys Gln Ala Glu Lys Gln Thr Lys 
                565                 570                 575     


Glu Ala Leu Thr Arg Lys Gln Gln Lys Cys Arg Arg Lys Asn Gln Asp 
            580                 585                 590         


Glu Glu Ser Gln Glu Ala Pro Glu Leu Leu Lys Arg Pro Lys Glu Tyr 
        595                 600                 605             


Thr Val Arg Phe Thr Phe Pro Asp Pro Pro Pro Leu Ser Pro Pro Val 
    610                 615                 620                 


Leu Gly Leu His Gly Val Thr Phe Gly Tyr Gln Gly Gln Lys Pro Leu 
625                 630                 635                 640 


Phe Lys Asn Leu Asp Phe Gly Ile Asp Met Asp Ser Arg Ile Cys Ile 
                645                 650                 655     


Val Gly Pro Asn Gly Val Gly Lys Ser Thr Leu Leu Leu Leu Leu Thr 
            660                 665                 670         


Gly Lys Leu Thr Pro Thr His Gly Glu Met Arg Lys Asn His Arg Leu 
        675                 680                 685             


Lys Ile Gly Phe Phe Asn Gln Gln Tyr Ala Glu Gln Leu Arg Met Glu 
    690                 695                 700                 


Glu Thr Pro Thr Glu Tyr Leu Gln Arg Gly Phe Asn Leu Pro Tyr Gln 
705                 710                 715                 720 


Asp Ala Arg Lys Cys Leu Gly Arg Phe Gly Leu Glu Ser His Ala His 
                725                 730                 735     


Thr Ile Gln Ile Cys Lys Leu Ser Gly Gly Gln Lys Ala Arg Val Val 
            740                 745                 750         


Phe Ala Glu Leu Ala Cys Arg Glu Pro Asp Val Leu Ile Leu Asp Glu 
        755                 760                 765             


Pro Thr Asn Asn Leu Asp Ile Glu Ser Ile Asp Ala Leu Gly Glu Ala 
    770                 775                 780                 


Ile Asn Glu Tyr Lys Gly Ala Val Ile Val Val Ser His Asp Ala Arg 
785                 790                 795                 800 


Leu Ile Thr Glu Thr Asn Cys Gln Leu Trp Val Val Glu Glu Gln Ser 
                805                 810                 815     


Val Ser Gln Ile Asp Gly Asp Phe Glu Asp Tyr Lys Arg Glu Val Leu 
            820                 825                 830         


Glu Ala Leu Gly Glu Val Met Val Ser Arg Pro Arg Glu 
        835                 840                 845 


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence of the VH domain of intrabody 3H2-1

<400>  42

Pro Ile Ala Val Ser Asp Tyr 
1               5           


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence of the VH chain of intrabody 3H2-VH

<400>  43

Gly Val Arg Gly Gly Tyr Gly Leu Asp Phe 
1               5                   10  


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 sequence of the VH chain of intrabody 5H4

<400>  44

Asp Gly Gly Leu Arg Glu Gly Phe Asp Cys 
1               5                   10  


<210>  45
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense strand of sh1 shRNA to LOC297607

<400>  45
gcgtaagatt agagagcctt taagttctct aaaggctctc taatcttaca aaaaaagatc       60

tcttaa                                                                  66


<210>  46
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense strand of sh2 shRNA to LOC297607

<400>  46
gctcttaact aaccgctttc taagttctct agaaagcggt tagttaagaa aaaaaagatc       60

tcttaa                                                                  66


