                         SEQUENCE LISTING

<110>  UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
       Vidyasagar, Sadasivan
       Okunieff, Paul
 
<120>  Use of Anoctamin as a Biomarker for Radiation Biodosimetry

<130>  UF.1070XC1PCT

<150>  61/710,413
<151>  2012-10-05

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  986
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Val Asn Glu Lys Tyr Ser Thr Leu Pro Ala Glu Asp Arg Ser 
1               5                   10                  15      


Val His Ile Ile Asn Ile Cys Ala Ile Glu Asp Ile Gly Tyr Leu Pro 
            20                  25                  30          


Ser Glu Gly Thr Leu Leu Asn Ser Leu Ser Val Asp Pro Asp Ala Glu 
        35                  40                  45              


Cys Lys Tyr Gly Leu Tyr Phe Arg Asp Gly Arg Arg Lys Val Asp Tyr 
    50                  55                  60                  


Ile Leu Val Tyr His His Lys Arg Pro Ser Gly Asn Arg Thr Leu Val 
65                  70                  75                  80  


Arg Arg Val Gln His Ser Asp Thr Pro Ser Gly Ala Arg Ser Val Lys 
                85                  90                  95      


Gln Asp His Pro Leu Pro Gly Lys Gly Ala Ser Leu Asp Ala Gly Ser 
            100                 105                 110         


Gly Glu Pro Pro Met Asp Tyr His Glu Asp Asp Lys Arg Phe Arg Arg 
        115                 120                 125             


Glu Glu Tyr Glu Gly Asn Leu Leu Glu Ala Gly Leu Glu Leu Glu Arg 
    130                 135                 140                 


Asp Glu Asp Thr Lys Ile His Gly Val Gly Phe Val Lys Ile His Ala 
145                 150                 155                 160 


Pro Trp Asn Val Leu Cys Arg Glu Ala Glu Phe Leu Lys Leu Lys Met 
                165                 170                 175     


Pro Thr Lys Lys Met Tyr His Ile Asn Glu Thr Arg Gly Leu Leu Lys 
            180                 185                 190         


Lys Ile Asn Ser Val Leu Gln Lys Ile Thr Asp Pro Ile Gln Pro Lys 
        195                 200                 205             


Val Ala Glu His Arg Pro Gln Thr Met Lys Arg Leu Ser Tyr Pro Phe 
    210                 215                 220                 


Ser Arg Glu Lys Gln His Leu Phe Asp Leu Ser Asp Lys Asp Ser Phe 
225                 230                 235                 240 


Phe Asp Ser Lys Thr Arg Ser Thr Ile Val Tyr Glu Ile Leu Lys Arg 
                245                 250                 255     


Thr Thr Cys Thr Lys Ala Lys Tyr Ser Met Gly Ile Thr Ser Leu Leu 
            260                 265                 270         


Ala Asn Gly Val Tyr Ala Ala Ala Tyr Pro Leu His Asp Gly Asp Tyr 
        275                 280                 285             


Asn Gly Glu Asn Val Glu Phe Asn Asp Arg Lys Leu Leu Tyr Glu Glu 
    290                 295                 300                 


Trp Ala Arg Tyr Gly Val Phe Tyr Lys Tyr Gln Pro Ile Asp Leu Val 
305                 310                 315                 320 


Arg Lys Tyr Phe Gly Glu Lys Ile Gly Leu Tyr Phe Ala Trp Leu Gly 
                325                 330                 335     


Val Tyr Thr Gln Met Leu Ile Pro Ala Ser Ile Val Gly Ile Ile Val 
            340                 345                 350         


Phe Leu Tyr Gly Cys Ala Thr Met Asp Glu Asn Ile Pro Ser Met Glu 
        355                 360                 365             


Met Cys Asp Gln Arg His Asn Ile Thr Met Cys Pro Leu Cys Asp Lys 
    370                 375                 380                 


Thr Cys Ser Tyr Trp Lys Met Ser Ser Ala Cys Ala Thr Ala Arg Ala 
385                 390                 395                 400 


Ser His Leu Phe Asp Asn Pro Ala Thr Val Phe Phe Ser Val Phe Met 
                405                 410                 415     


Ala Leu Trp Ala Ala Thr Phe Met Glu His Trp Lys Arg Lys Gln Met 
            420                 425                 430         


Arg Leu Asn Tyr Arg Trp Asp Leu Thr Gly Phe Glu Glu Glu Glu Glu 
        435                 440                 445             


Ala Val Lys Asp His Pro Arg Ala Glu Tyr Glu Ala Arg Val Leu Glu 
    450                 455                 460                 


Lys Ser Leu Lys Lys Glu Ser Arg Asn Lys Glu Lys Arg Arg His Ile 
465                 470                 475                 480 


Pro Glu Glu Ser Thr Asn Lys Trp Lys Gln Arg Val Lys Thr Ala Met 
                485                 490                 495     


Ala Gly Val Lys Leu Thr Asp Lys Val Lys Leu Thr Trp Arg Asp Arg 
            500                 505                 510         


Phe Pro Ala Tyr Leu Thr Asn Leu Val Ser Ile Ile Phe Met Ile Ala 
        515                 520                 525             


Val Thr Phe Ala Ile Val Leu Gly Val Ile Ile Tyr Arg Ile Ser Met 
    530                 535                 540                 


Ala Ala Ala Leu Ala Met Asn Ser Ser Pro Ser Val Arg Ser Asn Ile 
545                 550                 555                 560 


Arg Val Thr Val Thr Ala Thr Ala Val Ile Ile Asn Leu Val Val Ile 
                565                 570                 575     


Ile Leu Leu Asp Glu Val Tyr Gly Cys Ile Ala Arg Trp Leu Thr Lys 
            580                 585                 590         


Ile Glu Val Pro Lys Thr Glu Lys Ser Phe Glu Glu Arg Leu Ile Phe 
        595                 600                 605             


Lys Ala Phe Leu Leu Lys Phe Val Asn Ser Tyr Thr Pro Ile Phe Tyr 
    610                 615                 620                 


Val Ala Phe Phe Lys Gly Arg Phe Val Gly Arg Pro Gly Asp Tyr Val 
625                 630                 635                 640 


Tyr Ile Phe Arg Ser Phe Arg Met Glu Glu Cys Ala Pro Gly Gly Cys 
                645                 650                 655     


Leu Met Glu Leu Cys Ile Gln Leu Ser Ile Ile Met Leu Gly Lys Gln 
            660                 665                 670         


Leu Ile Gln Asn Asn Leu Phe Glu Ile Gly Ile Pro Lys Met Lys Lys 
        675                 680                 685             


Leu Ile Arg Tyr Leu Lys Leu Lys Gln Gln Ser Pro Pro Asp His Glu 
    690                 695                 700                 


Glu Cys Val Lys Arg Lys Gln Arg Tyr Glu Val Asp Tyr Asn Leu Glu 
705                 710                 715                 720 


Pro Phe Ala Gly Leu Thr Pro Glu Tyr Met Glu Met Ile Ile Gln Phe 
                725                 730                 735     


Gly Phe Val Thr Leu Phe Val Ala Ser Phe Pro Leu Ala Pro Leu Phe 
            740                 745                 750         


Ala Leu Leu Asn Asn Ile Ile Glu Ile Arg Leu Asp Ala Lys Lys Phe 
        755                 760                 765             


Val Thr Glu Leu Arg Arg Pro Val Ala Val Arg Ala Lys Asp Ile Gly 
    770                 775                 780                 


Ile Trp Tyr Asn Ile Leu Arg Gly Ile Gly Lys Leu Ala Val Ile Ile 
785                 790                 795                 800 


Asn Ala Phe Val Ile Ser Phe Thr Ser Asp Phe Ile Pro Arg Leu Val 
                805                 810                 815     


Tyr Leu Tyr Met Tyr Ser Lys Asn Gly Thr Met His Gly Phe Val Asn 
            820                 825                 830         


His Thr Leu Ser Ser Phe Asn Val Ser Asp Phe Gln Asn Gly Thr Ala 
        835                 840                 845             


Pro Asn Asp Pro Leu Asp Leu Gly Tyr Glu Val Gln Ile Cys Arg Tyr 
    850                 855                 860                 


Lys Asp Tyr Arg Glu Pro Pro Trp Ser Glu Asn Lys Tyr Asp Ile Ser 
865                 870                 875                 880 


Lys Asp Phe Trp Ala Val Leu Ala Ala Arg Leu Ala Phe Val Ile Val 
                885                 890                 895     


Phe Gln Asn Leu Val Met Phe Met Ser Asp Phe Val Asp Trp Val Ile 
            900                 905                 910         


Pro Asp Ile Pro Lys Asp Ile Ser Gln Gln Ile His Lys Glu Lys Val 
        915                 920                 925             


Leu Met Val Glu Leu Phe Met Arg Glu Glu Gln Asp Lys Gln Gln Leu 
    930                 935                 940                 


Leu Glu Thr Trp Met Glu Lys Glu Arg Gln Lys Asp Glu Pro Pro Cys 
945                 950                 955                 960 


Asn His His Asn Thr Lys Ala Cys Pro Asp Ser Leu Gly Ser Pro Ala 
                965                 970                 975     


Pro Ser His Ala Tyr His Gly Gly Val Leu 
            980                 985     


<210>  2
<211>  4811
<212>  DNA
<213>  Homo sapiens

<400>  2
aaaggcgggc cggctggcgt ccaagttcct gaccaggcgc gggccggccc gcgggaccag       60

cagccgggtg gcggcgcgat cggccccgag aggctcaggc gccccccgca tcgagcgcgc      120

gggccgggcg ggccagggcg gcgggcggag cgggaggcgg ccacgtcccc ggcgggcctg      180

ggcgcgggga ggcccggccc cctgcgagcg cgccgcgaac gctgcggtct ccgcccgcag      240

aggccgccgg ggccgtggat ggggagggcg cgccgcccgg cggtcccagc gcacaggcgg      300

ccacgatgag ggtcaacgag aagtactcga cgctcccggc cgaggaccgc agcgtccaca      360

tcatcaacat ctgcgccatc gaggacatcg gctacctgcc gtccgagggc acgctgctga      420

actccttatc tgtggaccct gatgccgagt gcaagtatgg cctgtacttc agggacggcc      480

ggcgcaaggt ggactacatc ctggtgtacc atcacaagag gccctcgggc aaccggaccc      540

tggtcaggag ggtgcagcac agcgacaccc cctctggggc tcgcagcgtc aagcaggacc      600

accccctgcc gggcaagggg gcgtcgctgg atgcaggctc gggggagccc ccgatggact      660

accacgagga tgacaagcgc ttccgcaggg aggagtacga gggcaacctc ctggaggcgg      720

gcctggagct ggagcgggac gaggacacta aaatccacgg agtcgggttt gtgaaaatcc      780

atgccccctg gaacgtgctg tgcagagagg ccgagtttct gaaactgaag atgccgacga      840

agaagatgta ccacattaat gagacccgtg gcctcctgaa aaaaatcaac tctgtgctcc      900

agaaaatcac agatcccatc cagcccaaag tggctgagca caggccccag accatgaaga      960

gactctccta tcccttctcc cgggagaagc agcatctatt tgacttgtct gataaggatt     1020

cctttttcga cagcaaaacc cggagcacga ttgtctatga gatcttgaag agaacgacgt     1080

gtacaaaggc caagtacagc atgggcatca cgagcctgct ggccaatggt gtgtacgcgg     1140

ctgcataccc actgcacgat ggagactaca acggtgaaaa cgtcgagttc aacgacagaa     1200

aactcctgta cgaagagtgg gcacgctatg gagttttcta taagtaccag cccatcgacc     1260

tggtcaggaa gtattttggg gagaagatcg gcctgtactt cgcctggctg ggcgtgtaca     1320

cccagatgct catccctgcc tccatcgtgg gaatcattgt cttcctgtac ggatgcgcca     1380

ccatggatga aaacatcccc agcatggaga tgtgtgacca gagacacaat atcaccatgt     1440

gcccgctttg cgacaagacc tgcagctact ggaagatgag ctcagcctgc gccacggccc     1500

gcgccagcca cctcttcgac aaccccgcca cggtcttctt ctctgtcttc atggccctct     1560

gggctgccac cttcatggag cactggaagc ggaaacagat gcgactcaac taccgctggg     1620

acctcacggg ctttgaagag gaagaggagg ctgtcaagga tcatcctaga gctgaatacg     1680

aagccagagt cttggagaag tctctgaaga aagagtccag aaacaaagag aagcgccggc     1740

atattccaga ggagtcaaca aacaaatgga agcagagggt taagacagcc atggcggggg     1800

tgaaattgac tgacaaagtg aagctgacat ggagagatcg gttcccagcc tacctcacta     1860

acttggtctc catcatcttc atgattgcag tgacgtttgc catcgtcctc ggcgtcatca     1920

tctacagaat ctccatggcc gccgccttgg ccatgaactc ctccccctcc gtgcggtcca     1980

acatccgggt cacagtcaca gccaccgcag tcatcatcaa cctagtggtc atcatcctcc     2040

tggacgaggt gtatggctgc atagcccgat ggctcaccaa gatcgaggtc ccaaagacgg     2100

agaaaagctt tgaggagagg ctgatcttca aggctttcct gctgaagttt gtgaattcct     2160

acacccccat cttttacgtg gcgttcttca aaggccggtt tgttggacgc ccgggcgact     2220

acgtgtacat tttccgttcc ttccgaatgg aagagtgtgc gccagggggc tgcctgatgg     2280

agctatgcat ccagctcagc atcatcatgc tggggaaaca gctgatccag aacaacctgt     2340

tcgagatcgg catcccgaag atgaagaagc tcatccgcta cctgaagctg aagcagcaga     2400

gcccccctga ccacgaggag tgtgtgaaga ggaaacagcg gtacgaggtg gattacaacc     2460

tggagccctt cgcgggcctc accccagagt acatggaaat gatcatccag tttggcttcg     2520

tcaccctgtt tgtcgcctcc ttccccctgg ccccactgtt tgcgctgctg aacaacatca     2580

tcgagatccg cctggacgcc aaaaagtttg tcactgagct ccgaaggccg gtagctgtca     2640

gagccaaaga catcggaatc tggtacaata tcctcagagg cattgggaag cttgctgtca     2700

tcatcaatgc cttcgtgatc tccttcacgt ctgacttcat cccgcgcctg gtgtacctct     2760

acatgtacag taagaacggg accatgcacg gcttcgtcaa ccacaccctc tcctccttca     2820

acgtcagtga cttccagaac ggcacggccc ccaatgaccc cctggacctg ggctacgagg     2880

tgcagatctg caggtataaa gactaccgag agccgccgtg gtcggaaaac aagtacgaca     2940

tctccaagga cttctgggcc gtcctggcag cccggctggc gtttgtcatc gtcttccaga     3000

acctggtcat gttcatgagc gactttgtgg actgggtcat cccggacatc cccaaggaca     3060

tcagccagca gatccacaag gagaaggtgc tcatggtgga gctgttcatg cgggaggagc     3120

aagacaagca gcagctgctg gaaacctgga tggagaagga gcggcagaag gacgagccgc     3180

cgtgcaacca ccacaacacc aaagcctgcc cagacagcct cggcagccca gcccccagcc     3240

atgcctacca cgggggcgtc ctgtagctat gccagcgggg ctgggcaggc cagccgggca     3300

tcctgaccga tgggcaccct ctcccagggc aggcggcttc ccgctcccac cagggcccgg     3360

tgggtcctgg gttttctgca aacatggagg accactttct gataggacat tttcctttct     3420

tctttctgtt ttctttccct tgtttttgca caaagccatt atgcagggaa tattttttaa     3480

tctgtagtat tcaagatgaa tcaaaatgat ggctggtaat acggcaataa ggtagcaaag     3540

gcaggtgctt tgcagaaaga atgcttggaa acttgagtct ccctagaggt gaaaagtgag     3600

cagaggcccg tagaaaccct cctctgaatc ctcctaattc cttaagatag atgcaaaatg     3660

gtaagccgag gcatcgcgca aaagctggtg cgatgcttca gggaaaatgg aaaacccacg     3720

caagaataat gattgattcc ggttccaaaa ggtgtcacct acctgtttca gaaaagttag     3780

actttccatc gccttttcct tccatcagtt gagtggctga gagagaagtg cctcatccct     3840

gagccacaca gggggcgtgg gagcatccca gttatccctg gaaagctaga aggggacaga     3900

ggtgtccctg attaagcagg aaacagcacc cttggcgtcc ccagcaggct ccccactgtc     3960

agccacacac ctgcccccat cacaccaagc cgacctcaga gttgttcatc ttccttatgg     4020

gacaaaaccg gttgaccaga aaatgggcag agagagatga cctcggaagc atttccacag     4080

atggtgtcag ggtttcaaga agtcttaggg cttccagggg tcccctggaa gctttagaat     4140

atttatgggt ttttttttca aatatcaatt atatggtaga ttgaggattt tttttctgta     4200

gctcaaaggt ggagggagtt tattagttaa ccaaatatcg ttgagaggaa tttaaaatac     4260

tgttactacc aaagattttt attaataaag gcttatattt tggtaacact tctctatatt     4320

tttactcaca ggaatgtcac tgttggacaa ttattttaaa agtgtataaa accaagtctc     4380

ataaatgata tgagtgatct aaatttgcag caatgatact aaacaactct ctgaaatttc     4440

tcaagcacca agagaaacat cattttagca aaggccagga ggaaaaatag aaataaattt     4500

gtcttgaaga tctcattgat gtgatgttac attcccttta atctgccaac tgtggtcaaa     4560

gttcataggt gtcgtacatt tccattattt gctaaaatca tgcaatctga tgcttctctt     4620

ttctcttgta cagtaagtag tttgaagtgg gttttgtata taaatactgt attaaaaatt     4680

aggcaattac caaaaatcct tttatggaaa ccattttttt aaaaagtgaa tgtacacaaa     4740

tccacagagg actgtggctg gacattcatc taaataaatt tgaatatacg acacttttct     4800

cacttgaaaa a                                                          4811


