               SEQUENCE LISTING

<110> CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

<120> TRATAMIENTO TERAPEUTICO DE LEUCEMIAS LINFOBLASTICAS AGUDAS T y B Y LINFOMAS HUMANOS POR INHIBICION DEL RECEPTOR DE INTERLEUQUINA-7 IL-7R

<130> 120130456 MARIA LUISA TORIBIO

<160> 8

<170> BiSSAP 1.0

<210> 1
<211> 1809
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1809
<223> /mol_type="DNA"
      /note="Secuencia codificante del ARN mensajero de la cadena alfa del receptor de la interleuquina 7 humana"
      /organism="Homo sapiens"

<400> 1
gtcttcctcc ctccctccct tcctcttact ctcattcatt tcatacacac tggctcacac      60

atctactctc tctctctatc tctctcagaa tgacaattct aggtacaact tttggcatgg     120

ttttttcttt acttcaagtc gtttctggag aaagtggcta tgctcaaaat ggagacttgg     180

aagatgcaga actggatgac tactcattct catgctatag ccagttggaa gtgaatggat     240

cgcagcactc actgacctgt gcttttgagg acccagatgt caacatcacc aatctggaat     300

ttgaaatatg tggggccctc gtggaggtaa agtgcctgaa tttcaggaaa ctacaagaga     360

tatatttcat cgagacaaag aaattcttac tgattggaaa gagcaatata tgtgtgaagg     420

ttggagaaaa gagtctaacc tgcaaaaaaa tagacctaac cactatagtt aaacctgagg     480

ctccttttga cctgagtgtc gtctatcggg aaggagccaa tgactttgtg gtgacattta     540

atacatcaca cttgcaaaag aagtatgtaa aagttttaat gcacgatgta gcttaccgcc     600

aggaaaagga tgaaaacaaa tggacgcatg tgaatttatc cagcacaaag ctgacactcc     660

tgcagagaaa gctccaaccg gcagcaatgt atgagattaa agttcgatcc atccctgatc     720

actattttaa aggcttctgg agtgaatgga gtccaagtta ttacttcaga actccagaga     780

tcaataatag ctcaggggag atggatccta tcttactaac catcagcatt ttgagttttt     840

tctctgtcgc tctgttggtc atcttggcct gtgtgttatg gaaaaaaagg attaagccta     900

tcgtatggcc cagtctcccc gatcataaga agactctgga acatctttgt aagaaaccaa     960

gaaaaaattt aaatgtgagt ttcaatcctg aaagtttcct ggactgccag attcataggg    1020

tggatgacat tcaagctaga gatgaagtgg aaggttttct gcaagatacg tttcctcagc    1080

aactagaaga atctgagaag cagaggcttg gaggggatgt gcagagcccc aactgcccat    1140

ctgaggatgt agtcatcact ccagaaagct ttggaagaga ttcatccctc acatgcctgg    1200

ctgggaatgt cagtgcatgt gacgccccta ttctctcctc ttccaggtcc ctagactgca    1260

gggagagtgg caagaatggg cctcatgtgt accaggacct cctgcttagc cttgggacta    1320

caaacagcac gctgccccct ccattttctc tccaatctgg aatcctgaca ttgaacccag    1380

ttgctcaggg tcagcccatt cttacttccc tgggatcaaa tcaagaagaa gcatatgtca    1440

ccatgtccag cttctaccaa aaccagtgaa gtgtaagaaa cccagactga acttaccgtg    1500

agcgacaaag atgatttaaa agggaagtct agagttccta gtctccctca cagcacagag    1560

aagacaaaat tagcaaaacc ccactacaca gtctgcaaga ttctgaaaca ttgctttgac    1620

cactcttcct gagttcagtg gcactcaaca tgagtcaaga gcatcctgct tctaccatgt    1680

ggatttggtc acaaggttta aggtgaccca atgattcagc tatttaaaaa aaaaagagga    1740

aagaatgaaa gagtaaagga aatgattgag gagtgaggaa ggcaggaaga gagcatgaga    1800

ggaaaaaaa                                                            1809


<210> 2
<211> 459
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..459
<223> /mol_type="protein"
      /note="Secuencia polipeptidica de la cadena alfa del receptor de la interleuquina 7 humana"
      /organism="Homo sapiens"

<400> 2
Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                   15    
Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                   25                  30        
Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                   40                  45            
Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                   55                  60                
Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                   70                  75                  80
Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                   90                  95    
Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                  105                110        
Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                  120                125            
Pro Glu Ala Pro Phe Asp Leu Ser Val Val Tyr Arg Glu Gly Ala Asn 
    130                  135                140                
Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                  150                155                  160
Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                  170                175    
Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                  185                190        
Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                  200                205            
Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                  215                220                
Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                  230                235                  240
Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
                245                  250                255    
Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
            260                  265                270        
Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
        275                  280                285            
Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu 
    290                  295                300                
Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val 
305                  310                315                  320
Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
                325                  330                335    
Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
            340                  345                350        
Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
        355                  360                365            
Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
    370                  375                380                
Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
385                  390                395                  400
Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
                405                  410                415    
Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
            420                  425                430        
Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
        435                  440                445            
Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    450                  455                

<210> 3
<211> 58
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..58
<223> /mol_type="RNA"
      /note="Secuencia de nucleotidos del shRNA numero 1 frente a la cadena alfa del IL-7R"
      /organism="Artificial Sequence"

<400> 3
ccggcggcag caauguauga gauuacucga guaaucucau acauugcugc cguuuuug       58


<210> 4
<211> 58
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..58
<223> /mol_type="RNA"
      /note="Secuencia de nucleotidos del shRNA numero 2 frente a la cadena alfa del IL-7R"
      /organism="Artificial Sequence"

<400> 4
ccggcccaga ugucaacauc accaacucga guuggugaug uugacaucug gguuuuug       58


<210> 5
<211> 58
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..58
<223> /mol_type="RNA"
      /note="Secuencia de nucleotidos del shRNA numero 3 frente a la cadena alfa del IL-7R"
      /organism="Artificial Sequence"

<400> 5
ccggccauuc uuacuucccu gggaucucga gaucccaggg aaguaagaau gguuuuug       58


<210> 6
<211> 58
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..58
<223> /mol_type="RNA"
      /note="Secuencia de nucleotidos del shRNA numero 4 frente a la cadena alfa del IL-7R"
      /organism="Artificial Sequence"

<400> 6
ccgggaagag auucaucccu cacaucucga gaugugaggg augaaucucu ucuuuuug       58


<210> 7
<211> 58
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..58
<223> /mol_type="RNA"
      /note="Secuencia de nucleotidos del shRNA numero 5 frente a la cadena alfa del IL-7R"
      /organism="Artificial Sequence"

<400> 7
ccggcugauu ggaaagagca auauacucga guauauugcu cuuuccaauc aguuuuug       58


<210> 8
<211> 58
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..58
<223> /mol_type="RNA"
      /note="Secuencia de nucleotidos de un shRNA que no reconoce ningun gen humano ni de raton"
      /organism="Artificial Sequence"

<400> 8
ccggcaacaa gaugaagagc accaacucga guuggugcuc uucaucuugu uguuuuug       58


