                         SEQUENCE LISTING

<110>  Neurimmune Holding AG et al.
 
<120>  Recombinant human antibodies for therapy and prevention of 
       polyomavirus-related diseases

<130>  NE30A41/P-WO

<150>  EP 12199837.1
<151>  2012-12-31

<160>  168   

<170>  PatentIn version 3.5

<210>  1
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(372)
<223>  NI-307.13G4 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(339)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  1
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gta cag cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt aca gcc tct gga ttc acc ttt acc tcc tat         96
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Thr Ser Tyr           
            20                  25                  30                    

gcc ctg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca gca att agt agt ggt cgt ggt tac aca tac tac gca gac tcc gtg        192
Ser Ala Ile Ser Ser Gly Arg Gly Tyr Thr Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agt ctg aga gcc gag gac acg gcc gta tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aaa gat ggc acc cta cgt gga tac aac tat ggt tac ata gat gat        336
Ala Lys Asp Gly Thr Leu Arg Gly Tyr Asn Tyr Gly Tyr Ile Asp Asp           
            100                 105                 110                   

atc tgg ggc caa ggc acc ctg gtc acc gtc tcc tcg                        372
Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                           
        115                 120                                           


<210>  2
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Ser Gly Arg Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Thr Leu Arg Gly Tyr Asn Tyr Gly Tyr Ile Asp Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  3
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-307.13G4 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(171)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  3
gac atc cag atg acc cag tct cca tcg tca ctg tct gca tct gta gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgt cgg gcg agt cag ggc atc agc aat tat         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr           
            20                  25                  30                    

tta gcc tgg ctt cag cag aaa cca ggg aaa gcc cct aag ccc ctg atc        144
Leu Ala Trp Leu Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile           
        35                  40                  45                        

tat gcc gta tcc att ttg caa agt ggg gtc cca tca aag ttc agc ggc        192
Tyr Ala Val Ser Ile Leu Gln Ser Gly Val Pro Ser Lys Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggg aca gat ttc act ctc acc atc agc agc ctg cag cct        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gag gat ttt gca act tat tac tgc caa cag tat aag agt tac cct tac        288
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Lys Ser Tyr Pro Tyr           
                85                  90                  95                

acc ttt ggc cag ggg acc aag ctg gag atc aaa                            321
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys                               
            100                 105                                       


<210>  4
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Leu Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ala Val Ser Ile Leu Gln Ser Gly Val Pro Ser Lys Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Lys Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  5
<211>  351
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(351)
<223>  NI-307.19F10 VH  variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(318)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  5
gag gtg cag ctg gtg gag tct ggg gga ggc tta gtt cag ccg ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc gtg agc ctc tcc tgt gca gcc tct gga ttc acc ttc cct gtc tac         96
Ser Val Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Val Tyr           
            20                  25                  30                    

tgg atg cac tgg gtc cgc caa gct cca gag aag ggc ctg atg tgg gtc        144
Trp Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Met Trp Val           
        35                  40                  45                        

tca cgg att agt cct gat ggg acc ata gta gac tac gcg ggc tcc gtg        192
Ser Arg Ile Ser Pro Asp Gly Thr Ile Val Asp Tyr Ala Gly Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc gtc tcc aga gac aac gcc aag aac att ctt tat        240
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ile Leu Tyr           
65                  70                  75                  80            

ctg caa att caa cgt ctg act gcc gag gac acg gct gtg tat ttc tgt        288
Leu Gln Ile Gln Arg Leu Thr Ala Glu Asp Thr Ala Val Tyr Phe Cys           
                85                  90                  95                

aca aag gac ttc gat gtt gcg agt gga ttc tgg ggc cag gga acc ctg        336
Thr Lys Asp Phe Asp Val Ala Ser Gly Phe Trp Gly Gln Gly Thr Leu           
            100                 105                 110                   

gtc acc gtc tcc tcg                                                    351
Val Thr Val Ser Ser                                                       
        115                                                               


<210>  6
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Val Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Met Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Pro Asp Gly Thr Ile Val Asp Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Ile Gln Arg Leu Thr Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Lys Asp Phe Asp Val Ala Ser Gly Phe Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  7
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)
<223>  NI-307.19F10 VL  variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (68)..(108)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(300)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  7
cag tct gcc ctg act cag cct ccc tcc gcg tcc ggg tct cct gga cag         48
Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln           
1               5                   10                  15                

tca gtc acc atc tcc tgc act gga tcc aaa agt gac gtt ggt act tgt         96
Ser Val Thr Ile Ser Cys Thr Gly Ser Lys Ser Asp Val Gly Thr Cys           
            20                  25                  30                    

cac ttt gtc tcc tgg tac cag cag cac cca ggc aaa gtc ccc aaa ctc        144
His Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu           
        35                  40                  45                        

gtc att tat gag ggc aat aag cgg ccc tca ggg gtc cct gat cgc ttc        192
Val Ile Tyr Glu Gly Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe           
    50                  55                  60                            

tct gcc tcc aag tct ggc aac acg gcc tcc ctc acc atc tct ggg ctg        240
Ser Ala Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu           
65                  70                  75                  80            

cag cct ggc gac gag gcg gac tat tat tgc agc aca tgt gca ggc ccc        288
Gln Pro Gly Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Cys Ala Gly Pro           
                85                  90                  95                

aac aac tat gtc ttc gga act ggg acc aag gtc acc gtc ctt                330
Asn Asn Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu                   
            100                 105                 110                   


<210>  8
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ser Lys Ser Asp Val Gly Thr Cys 
            20                  25                  30          


His Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Val Pro Lys Leu 
        35                  40                  45              


Val Ile Tyr Glu Gly Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Ala Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Pro Gly Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Cys Ala Gly Pro 
                85                  90                  95      


Asn Asn Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  9
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(363)
<223>  NI-307.19F8 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(330)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  9
gag gtg cag ctg gtg gag tct ggg gga ggc ctg gtc aag cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttc agt agc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

tac atg aac tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca tcc att agt agt agt agt agt tac ata tac tac gca gac tca gtg        192
Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc aga gac aac gcc aag aac tca ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aca gcc gag gac acg gct gtg tat tac tgt        288
Leu Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gat ccc cgc cta caa cta tgg ttc atg ttt gac tac tgg ggc        336
Ala Arg Asp Pro Arg Leu Gln Leu Trp Phe Met Phe Asp Tyr Trp Gly           
            100                 105                 110                   

cag gga acc ctg gtc acc gtc tcc tcg                                    363
Gln Gly Thr Leu Val Thr Val Ser Ser                                       
        115                 120                                           


<210>  10
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Arg Leu Gln Leu Trp Phe Met Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  11
<211>  348
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(348)
<223>  NI-307.19F8 VL variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(102)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (280)..(318)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  11
cag cct gtg ctg act cag cca cct tct gca tca gcc tcc ctg gga gcc         48
Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Ala Ser Leu Gly Ala           
1               5                   10                  15                

tcg gtc aca ctc acc tgc acc ctg agc agc ggc tac agt aat tat aaa         96
Ser Val Thr Leu Thr Cys Thr Leu Ser Ser Gly Tyr Ser Asn Tyr Lys           
            20                  25                  30                    

gtg gac tgg tac cag cag aga cca ggg gag ggc ccc cgc ttt gtg atg        144
Val Asp Trp Tyr Gln Gln Arg Pro Gly Glu Gly Pro Arg Phe Val Met           
        35                  40                  45                        

cga gtg ggc act ggt ggg att gtg gga tcc aag ggg gat ggc atc cct        192
Arg Val Gly Thr Gly Gly Ile Val Gly Ser Lys Gly Asp Gly Ile Pro           
    50                  55                  60                            

gat cgc ttc tca gtc ttg ggc tca ggc ctg aat cgg tac ctg acc atc        240
Asp Arg Phe Ser Val Leu Gly Ser Gly Leu Asn Arg Tyr Leu Thr Ile           
65                  70                  75                  80            

aag gac atc cag gaa gag gat gag agt gac tac cac tgt ggg gca gac        288
Lys Asp Ile Gln Glu Glu Asp Glu Ser Asp Tyr His Cys Gly Ala Asp           
                85                  90                  95                

cat ggc agt ggg agc aac ttc gtg tat gtc ttc gga act ggg acc aag        336
His Gly Ser Gly Ser Asn Phe Val Tyr Val Phe Gly Thr Gly Thr Lys           
            100                 105                 110                   

gtc acc gtc cta                                                        348
Val Thr Val Leu                                                           
        115                                                               


<210>  12
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Thr Cys Thr Leu Ser Ser Gly Tyr Ser Asn Tyr Lys 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Arg Pro Gly Glu Gly Pro Arg Phe Val Met 
        35                  40                  45              


Arg Val Gly Thr Gly Gly Ile Val Gly Ser Lys Gly Asp Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Val Leu Gly Ser Gly Leu Asn Arg Tyr Leu Thr Ile 
65                  70                  75                  80  


Lys Asp Ile Gln Glu Glu Asp Glu Ser Asp Tyr His Cys Gly Ala Asp 
                85                  90                  95      


His Gly Ser Gly Ser Asn Phe Val Tyr Val Phe Gly Thr Gly Thr Lys 
            100                 105                 110         


Val Thr Val Leu 
        115     


<210>  13
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(360)
<223>  NI-307.11G6 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(327)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  13
cag gtg cag ctg gtg gag tct ggg gga gac ttg gtc aag cct gga ggg         48
Gln Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttc agt gac cac         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His           
            20                  25                  30                    

tac atg agc tgg atc cgc cag gct cca ggg aag ggg ctg gaa tgg gtt        144
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca tac att agt act aga agt act tac aca aac tac gca gac tct gtg        192
Ser Tyr Ile Ser Thr Arg Ser Thr Tyr Thr Asn Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc aga gac aac gcc aag aac tca cta tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr           
65                  70                  75                  80            

ctg cac atg aac agc ctg aga acc gag gac acg gct gtt tat tac tgt        288
Leu His Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gat tac tct gat act agt gga ccc cct gac tac tgg ggc cag        336
Ala Arg Asp Tyr Ser Asp Thr Ser Gly Pro Pro Asp Tyr Trp Gly Gln           
            100                 105                 110                   

ggc acc ctg gtc acc gtc tcc tcg                                        360
Gly Thr Leu Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  14
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  14

Gln Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Thr Arg Ser Thr Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Ser Asp Thr Ser Gly Pro Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  15
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)
<223>  NI-307.11G6 variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(105)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (268)..(300)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  15
cag tct gtg ctg act cag cca ccc tca gcg tct ggg acc ccc ggg cag         48
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln           
1               5                   10                  15                

agg gtc acc atc tct tgt tct ggg agc aac tcc aac atc gga agt aat         96
Arg Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser Asn           
            20                  25                  30                    

tat gta tac tgg tac cag cag ctc cca gga acg gcc ccc aaa ctc gtc        144
Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Val           
        35                  40                  45                        

atc tat agg aat act cag cgg ccc tca ggg gtc cct gac cga ttc tct        192
Ile Tyr Arg Asn Thr Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser           
    50                  55                  60                            

ggc tcc aag tct ggc acc tca gcc tcc ctg gcc atc agt ggg ctc cgg        240
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg           
65                  70                  75                  80            

tcc gaa gat gag gct gat tat tac tgt gca gca tgg gat gac agc ctg        288
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu           
                85                  90                  95                

agt ggt ctg gtg ttc ggc gga ggg acc aag ctg acc gtc ctg                330
Ser Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                   
            100                 105                 110                   


<210>  16
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Val 
        35                  40                  45              


Ile Tyr Arg Asn Thr Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  17
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(357)
<223>  NI-307.17F12 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (151)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(324)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  17
cag ctg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg ggg         48
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly           
1               5                   10                  15                

acc ctg tcc ctc acc tgc gct gtc tct ggt gac tcc atc acc aat act         96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Asp Ser Ile Thr Asn Thr           
            20                  25                  30                    

aac tgg tgg tgt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg        144
Asn Trp Trp Cys Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp           
        35                  40                  45                        

att ggg gaa atc ttt cat agt ggg ggc acc aac tac aac ccg tcc ctc        192
Ile Gly Glu Ile Phe His Ser Gly Gly Thr Asn Tyr Asn Pro Ser Leu           
    50                  55                  60                            

aag agt cga gtc acc atg tca gta gac aag gcc aag aac cag ttc tcc        240
Lys Ser Arg Val Thr Met Ser Val Asp Lys Ala Lys Asn Gln Phe Ser           
65                  70                  75                  80            

ctg aag gtg aac tct gtg acc gcc gcg gac acg gcc gtg tac ttc tgt        288
Leu Lys Val Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys           
                85                  90                  95                

acg acc aac ccc ggg ggg gga gat ggc tac agt tac tgg ggc cag ggc        336
Thr Thr Asn Pro Gly Gly Gly Asp Gly Tyr Ser Tyr Trp Gly Gln Gly           
            100                 105                 110                   

acc ctg gtc acc gtc tcc tcg                                            357
Thr Leu Val Thr Val Ser Ser                                               
        115                                                               


<210>  18
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  18

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Asp Ser Ile Thr Asn Thr 
            20                  25                  30          


Asn Trp Trp Cys Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Phe His Ser Gly Gly Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Ser Val Asp Lys Ala Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Val Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Thr Asn Pro Gly Gly Gly Asp Gly Tyr Ser Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  19
<211>  327
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(327)
<223>  NI-307.17F12 variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(108)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(300)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  19
cag tct gcc ctg act cag cct cgc tca gtg tcc ggg tct cct gga cag         48
Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln           
1               5                   10                  15                

tca gtc acc atc tcc tgc act gga acc agc agt gat gtt ggt ggt tat         96
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr           
            20                  25                  30                    

aac tat gtc tcc tgg tac caa caa cac cca ggc aaa gcc ccc aat ctc        144
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Asn Leu           
        35                  40                  45                        

atg att tct gag gtc agt aag cgg ccc tca ggg gtc cct gat cgc ttc        192
Met Ile Ser Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe           
    50                  55                  60                            

tct ggc tcc aag tct ggc aac acg gcc tcc ctg acc atc tct ggg ctc        240
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu           
65                  70                  75                  80            

cag gct gag gat gag gct gat tat ttc tgc tgc tca tat gca ggc agt        288
Gln Ala Glu Asp Glu Ala Asp Tyr Phe Cys Cys Ser Tyr Ala Gly Ser           
                85                  90                  95                

tac agg gtc ttc gga act ggg acc aag gtc acc gtc cta                    327
Tyr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu                       
            100                 105                                       


<210>  20
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Asn Leu 
        35                  40                  45              


Met Ile Ser Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Phe Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Tyr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 


<210>  21
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(372)
<223>  NI-307.6A2 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (151)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(339)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  21
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu           
1               5                   10                  15                

acc ctg tcc ctc acc tgc gct gtc tct gga ggc tcc gtc agc agt agt         96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Val Ser Ser Ser           
            20                  25                  30                    

tac tgg tac agt tgg gtc cgc cag ctc cca gga aag ggg ctg gaa tgg        144
Tyr Trp Tyr Ser Trp Val Arg Gln Leu Pro Gly Lys Gly Leu Glu Trp           
        35                  40                  45                        

atc gga gaa atc ttt cat act ggg gac acc aac tac aac ccg tcc ctc        192
Ile Gly Glu Ile Phe His Thr Gly Asp Thr Asn Tyr Asn Pro Ser Leu           
    50                  55                  60                            

gag agt cga gtc acc att tca ata gac acg tcc aag aac cag ttg tcc        240
Glu Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Leu Ser           
65                  70                  75                  80            

ctg gat gtg acc tct gcg acc gcc gcg gac acg gcc gta tac tac tgc        288
Leu Asp Val Thr Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gat tat tgt act gat agc ggt tgc gac tct gat gct ctt gat        336
Ala Arg Asp Tyr Cys Thr Asp Ser Gly Cys Asp Ser Asp Ala Leu Asp           
            100                 105                 110                   

gtc tgg ggc cac ggg aca atg gtc acc gtc tct tcg                        372
Val Trp Gly His Gly Thr Met Val Thr Val Ser Ser                           
        115                 120                                           


<210>  22
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Trp Tyr Ser Trp Val Arg Gln Leu Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Phe His Thr Gly Asp Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Glu Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Leu Ser 
65                  70                  75                  80  


Leu Asp Val Thr Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Cys Thr Asp Ser Gly Cys Asp Ser Asp Ala Leu Asp 
            100                 105                 110         


Val Trp Gly His Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  23
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)
<223>  NI-307.6A2 variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(108)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(300)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  23
cag tct gcc ctg act cag cct gcc tcc gtg tct ggg tct cct gga cag         48
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln           
1               5                   10                  15                

tcg atc acc atc tcc tgc act gga acc acc aaa gat gtt gga aat tat         96
Ser Ile Thr Ile Ser Cys Thr Gly Thr Thr Lys Asp Val Gly Asn Tyr           
            20                  25                  30                    

aac ctt gtc tcc tgg tac caa cag cac ccg ggc aaa gcc ccc aga ctc        144
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Arg Leu           
        35                  40                  45                        

gtg att tat gag gtc agt gag cgg ccc tca ggg gtt tct aat cgc ttc        192
Val Ile Tyr Glu Val Ser Glu Arg Pro Ser Gly Val Ser Asn Arg Phe           
    50                  55                  60                            

tct ggc tcc aag tct ggc aac acg gcc tcc ctg aca atc tct ggg ctc        240
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu           
65                  70                  75                  80            

cag gct gag gac gag gct gat tat cac tgc tgc tca tat gca ggt agt        288
Gln Ala Glu Asp Glu Ala Asp Tyr His Cys Cys Ser Tyr Ala Gly Ser           
                85                  90                  95                

ggc aca tcg gta ttc ggc gga ggg acc aag gtg acc gtc cta                330
Gly Thr Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu                   
            100                 105                 110                   


<210>  24
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Thr Lys Asp Val Gly Asn Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Arg Leu 
        35                  40                  45              


Val Ile Tyr Glu Val Ser Glu Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr His Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Gly Thr Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  25
<211>  375
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(375)
<223>  NI-307.5H3 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (151)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(342)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  25
cag gtg cag ctg cag gag tcc ggc cca gga ctg ctg aag cct ttg gga         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Leu Lys Pro Leu Gly           
1               5                   10                  15                

acc ctg tcc ctc atc tgc gat gtc tct ggt gac tcc atc agt agt agt         96
Thr Leu Ser Leu Ile Cys Asp Val Ser Gly Asp Ser Ile Ser Ser Ser           
            20                  25                  30                    

aac tgg tgg agt tgg gtc cgc cag tcc ccc cgg aag ggg ctg gag tgg        144
Asn Trp Trp Ser Trp Val Arg Gln Ser Pro Arg Lys Gly Leu Glu Trp           
        35                  40                  45                        

att ggc gaa atc tat cat agt ggg agg acc aac tac aat ccg tca ctc        192
Ile Gly Glu Ile Tyr His Ser Gly Arg Thr Asn Tyr Asn Pro Ser Leu           
    50                  55                  60                            

acg aat cga gtt acc att tca gtg gac aag tcc aag aac cag ttc tcc        240
Thr Asn Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser           
65                  70                  75                  80            

ctg aat ctg aac tct gtg acc gcc gcg gac acg ggc gta tat tat tgt        288
Leu Asn Leu Asn Ser Val Thr Ala Ala Asp Thr Gly Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga tgg gat tat tat tat aat aat gat tat tat atc cgc ggt ttt        336
Ala Arg Trp Asp Tyr Tyr Tyr Asn Asn Asp Tyr Tyr Ile Arg Gly Phe           
            100                 105                 110                   

gat ata tgg ggc caa ggg aca atg gtc acc gtc tct tcg                    375
Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser                       
        115                 120                 125                       


<210>  26
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  26

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Leu Lys Pro Leu Gly 
1               5                   10                  15      


Thr Leu Ser Leu Ile Cys Asp Val Ser Gly Asp Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Ser Pro Arg Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Arg Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Thr Asn Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Asn Leu Asn Ser Val Thr Ala Ala Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Tyr Tyr Tyr Asn Asn Asp Tyr Tyr Ile Arg Gly Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  27
<211>  327
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(327)
<223>  NI-307.5H3 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(105)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (268)..(297)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  27
gaa att gtg ttg acg cag tct cca ggc atc ctg tct ttg tct cca ggg         48
Glu Ile Val Leu Thr Gln Ser Pro Gly Ile Leu Ser Leu Ser Pro Gly           
1               5                   10                  15                

gaa aga gcc acc ctc tcc tgc agg gcc agt cag agt gtt gac agc aac         96
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Ser Asn           
            20                  25                  30                    

tac cta gcc tgg tac cag cag aaa cct ggc cag gct ccc agg ctc ctc        144
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu           
        35                  40                  45                        

atc tat agt aca tcc acc agg gcc gct ggc gtc cca gac agg ttc agt        192
Ile Tyr Ser Thr Ser Thr Arg Ala Ala Gly Val Pro Asp Arg Phe Ser           
    50                  55                  60                            

ggc agt ggg tct ggg aca gac ttc gct ctc acc atc agc gga ctg gag        240
Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Gly Leu Glu           
65                  70                  75                  80            

cct gaa gat ttt gca gtg tat tac tgt cag cag tgg ggt ggc tca cct        288
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Gly Gly Ser Pro           
                85                  90                  95                

ccg atc acc ttc ggc caa ggg aca cga ctg gag att aaa                    327
Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys                       
            100                 105                                       


<210>  28
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  28

Glu Ile Val Leu Thr Gln Ser Pro Gly Ile Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Arg Ala Ala Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Gly Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Gly Gly Ser Pro 
                85                  90                  95      


Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 


<210>  29
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(372)
<223>  NI-307.25G10 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(195)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (292)..(339)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  29
gag gtg cag ctg gtg gag tct ggg gga ggc tta gta cag ccg ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gtg gcc tct gga atc atc ttc aaa gac tac         96
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ile Ile Phe Lys Asp Tyr           
            20                  25                  30                    

gac ttc cac tgg gtc cga caa gtt aaa gaa aaa ggt ctg gag tgg gtc        144
Asp Phe His Trp Val Arg Gln Val Lys Glu Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca gct att ggt act gct ggt gac cca tat tat gca gct tcc gtg aag        192
Ser Ala Ile Gly Thr Ala Gly Asp Pro Tyr Tyr Ala Ala Ser Val Lys           
    50                  55                  60                            

ggc cgc ttc acc gtc tcc agg gaa aat ggc aag aac tcc gtg tat ctt        240
Gly Arg Phe Thr Val Ser Arg Glu Asn Gly Lys Asn Ser Val Tyr Leu           
65                  70                  75                  80            

cga atg aac aac gtg gga gcc ggt gac acg gct ctg tat tat tgt acg        288
Arg Met Asn Asn Val Gly Ala Gly Asp Thr Ala Leu Tyr Tyr Cys Thr           
                85                  90                  95                

agc ggc aat tac ttc gat aga ggt tct ttc agg ccg agt gct ttt gat        336
Ser Gly Asn Tyr Phe Asp Arg Gly Ser Phe Arg Pro Ser Ala Phe Asp           
            100                 105                 110                   

atg tgg ggc caa ggg aca atg gtc acc gtc tct tcg                        372
Met Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser                           
        115                 120                                           


<210>  30
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ile Ile Phe Lys Asp Tyr 
            20                  25                  30          


Asp Phe His Trp Val Arg Gln Val Lys Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Thr Ala Gly Asp Pro Tyr Tyr Ala Ala Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Glu Asn Gly Lys Asn Ser Val Tyr Leu 
65                  70                  75                  80  


Arg Met Asn Asn Val Gly Ala Gly Asp Thr Ala Leu Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Gly Asn Tyr Phe Asp Arg Gly Ser Phe Arg Pro Ser Ala Phe Asp 
            100                 105                 110         


Met Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  31
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(333)
<223>  NI-307.25G10 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(105)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (268)..(303)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  31
gaa att gtg ctg act cag tct cca ggc acc ctg tct ttg tct cca ggg         48
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly           
1               5                   10                  15                

gaa aga gcc acc ctc tcc tgc tgg gcc agt cag agt gtt tct agc aac         96
Glu Arg Ala Thr Leu Ser Cys Trp Ala Ser Gln Ser Val Ser Ser Asn           
            20                  25                  30                    

tac tta gcc tgg tat cag cac aaa cct ggc cag gct ccc aga ctc ctc        144
Tyr Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu           
        35                  40                  45                        

atc ttt cgc gca tct cgt agg gcc act gac atc cca gag agg ttc agt        192
Ile Phe Arg Ala Ser Arg Arg Ala Thr Asp Ile Pro Glu Arg Phe Ser           
    50                  55                  60                            

gcc gga ggg tct ggg aca gac ttc act ctc acc atc agc aga ctg gaa        240
Ala Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu           
65                  70                  75                  80            

gct gaa gac tct gca gtc tat tac tgt cag gag tat ggt agt gca cct        288
Ala Glu Asp Ser Ala Val Tyr Tyr Cys Gln Glu Tyr Gly Ser Ala Pro           
                85                  90                  95                

ccg gcg tcg atc acg ttc ggc caa ggg aca cga ctg gag att aaa            333
Pro Ala Ser Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys               
            100                 105                 110                   


<210>  32
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  32

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Trp Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Phe Arg Ala Ser Arg Arg Ala Thr Asp Ile Pro Glu Arg Phe Ser 
    50                  55                  60                  


Ala Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Ala Glu Asp Ser Ala Val Tyr Tyr Cys Gln Glu Tyr Gly Ser Ala Pro 
                85                  90                  95      


Pro Ala Ser Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110     


<210>  33
<211>  339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(339)
<223>  NI-307.26E10 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(195)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (292)..(306)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  33
gag gtg cag ctg gtg gag tct ggg gga ggc ctg gtc ctg ccg ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gtc tct gga ttc act gtc aga aat gag         96
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Val Arg Asn Glu           
            20                  25                  30                    

tac atg agg tgg gcc cgc cag gct cca ggg agg ggg ctg gag tgg gtc        144
Tyr Met Arg Trp Ala Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val           
        35                  40                  45                        

tca gtg att tac aga gat ggc cag aca cac cac gca gac acc gtg aag        192
Ser Val Ile Tyr Arg Asp Gly Gln Thr His His Ala Asp Thr Val Lys           
    50                  55                  60                            

ggc aga ttc gac gtc tcc aaa gac act tcc aag aac acg atg tac ctt        240
Gly Arg Phe Asp Val Ser Lys Asp Thr Ser Lys Asn Thr Met Tyr Leu           
65                  70                  75                  80            

cag atg cac aat ctg aga gtc gac gac acg gcc atc tat tac tgt gcg        288
Gln Met His Asn Leu Arg Val Asp Asp Thr Ala Ile Tyr Tyr Cys Ala           
                85                  90                  95                

agg ggg cat tac ggt cct tgg ggc cag ggc acc ctg gtc acc gtc tcc        336
Arg Gly His Tyr Gly Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser           
            100                 105                 110                   

tcg                                                                    339
Ser                                                                       
                                                                          


<210>  34
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Val Arg Asn Glu 
            20                  25                  30          


Tyr Met Arg Trp Ala Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Arg Asp Gly Gln Thr His His Ala Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Asp Val Ser Lys Asp Thr Ser Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met His Asn Leu Arg Val Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly His Tyr Gly Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  35
<211>  327
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(327)
<223>  NI-307.26E10 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(297)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  35
gac atc cag atg acc cag tct cct tcc acc ctg cct gca tct gta gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Pro Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgc cgg gcc agt cag agt att aat aat tgg         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Asn Trp           
            20                  25                  30                    

ttg gcc tgg tat cag cag aag cca ggg aaa gcc cct aac ctc ctg att        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile           
        35                  40                  45                        

tat gat gcc tcc aat ttg gaa act ggg gtc cca tca agg ttc agc ggc        192
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggg aca gaa ttc act ctc acc atc agc agc ctg cag cct        240
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gat gat ttt gca act tat tac tgt cag cag tat aat agt cat tct cac        288
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser His Ser His           
                85                  90                  95                

acg tgg acg ttc ggc caa ggg acc aag gtg gaa atc aaa                    327
Thr Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys                       
            100                 105                                       


<210>  36
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Pro Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser His Ser His 
                85                  90                  95      


Thr Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  37
<211>  348
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(348)
<223>  NI-307.1E1 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(204)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (301)..(315)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  37
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gta aag ccg ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly           
1               5                   10                  15                

tcc ctt aga ctc tcc tgt gca gcc tct gga ttc ata ttt agt gac gcc         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asp Ala           
            20                  25                  30                    

tgg atg aac tgg gtc cgc cag gct cca ggg aag gga ctg gag tgg gtt        144
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

ggc cat att aaa agc aga cct gct ggt ggg aca act gag tac gct gca        192
Gly His Ile Lys Ser Arg Pro Ala Gly Gly Thr Thr Glu Tyr Ala Ala           
    50                  55                  60                            

ccc gtg aaa ggc aga ttc acc atc tca aga gat gat tct aca gac aca        240
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Thr Asp Thr           
65                  70                  75                  80            

cta tat ctc caa atg aac aac ctg aaa gcc gag gac aca gcc gtc tat        288
Leu Tyr Leu Gln Met Asn Asn Leu Lys Ala Glu Asp Thr Ala Val Tyr           
                85                  90                  95                

tac tgt tcc aca ggg cac tat ggt gtc tat ggg ctg gga acc ctg gtc        336
Tyr Cys Ser Thr Gly His Tyr Gly Val Tyr Gly Leu Gly Thr Leu Val           
            100                 105                 110                   

acc gtc tcc tcg                                                        348
Thr Val Ser Ser                                                           
        115                                                               


<210>  38
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly His Ile Lys Ser Arg Pro Ala Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Thr Asp Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Thr Gly His Tyr Gly Val Tyr Gly Leu Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  39
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  NI-307.1E1 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(294)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  39
gac atc cag atg acc cag tct cct tcc acc ctg tct gca tct gta gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgc cgg gcc agt cag agt att aga gac tac         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Asp Tyr           
            20                  25                  30                    

ttg gcc tgg tat cag cag aaa cca ggg aaa gcc cct aaa ctt cta atc        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile           
        35                  40                  45                        

tat gat ggc tcc att ttg gaa ggt ggg gtc cca tca agg ttc agc ggc        192
Tyr Asp Gly Ser Ile Leu Glu Gly Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gta tct ggg aca gat ttc act ctc acc atc agc agt ctg cag tct        240
Ser Val Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser           
65                  70                  75                  80            

gat gat ttt gca act tat tac tgc caa cag tat act agt tat tct tcg        288
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Thr Ser Tyr Ser Ser           
                85                  90                  95                

tgg acg ttc ggc caa ggg acc aag gtg gaa atc aaa                        324
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys                           
            100                 105                                       


<210>  40
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Gly Ser Ile Leu Glu Gly Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Val Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Thr Ser Tyr Ser Ser 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  41
<211>  378
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(378)
<223>  NI-307.24C6 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(111)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (154)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(345)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  41
cag ctg cag ctg cag gag tcg ggc cca gga ctg gtg aag ccc tcg ggg         48
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly           
1               5                   10                  15                

acc ctg tcc ctc att tgt gtt gtc tct ggt tcc tcc atc aga agt aat         96
Thr Leu Ser Leu Ile Cys Val Val Ser Gly Ser Ser Ile Arg Ser Asn           
            20                  25                  30                    

att tgg tgg tgg aat tgg gtc cgc cag tcc cca ggg aag ggg ctt gag        144
Ile Trp Trp Trp Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu           
        35                  40                  45                        

tgg att ggg gaa atc tat cat agt ggg agt acc aat tac agc ccg tcc        192
Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Ser Pro Ser           
    50                  55                  60                            

ctc aag agt cga gtc acc atg tca gta gac aac tcc aag aac cag ttc        240
Leu Lys Ser Arg Val Thr Met Ser Val Asp Asn Ser Lys Asn Gln Phe           
65                  70                  75                  80            

tcc ctg aaa atg agc tct gtg acc gcc gcg gac acg gcc gta tat ttc        288
Ser Leu Lys Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe           
                85                  90                  95                

tgt gcg ata aac acc agg act tcg atc tct gga gtg ctc tat gat act        336
Cys Ala Ile Asn Thr Arg Thr Ser Ile Ser Gly Val Leu Tyr Asp Thr           
            100                 105                 110                   

ttt gat gtc tgg ggc caa ggg aca atg gtc acc gtc tct tcg                378
Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser                   
        115                 120                 125                       


<210>  42
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  42

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Ile Cys Val Val Ser Gly Ser Ser Ile Arg Ser Asn 
            20                  25                  30          


Ile Trp Trp Trp Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Val Asp Asn Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Ile Asn Thr Arg Thr Ser Ile Ser Gly Val Leu Tyr Asp Thr 
            100                 105                 110         


Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  43
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  NI-307.24C6 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(294)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  43
gaa att gtg ctg act cag tct cca gcc acc ctg tct ttg tct tca ggg         48
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Ser Gly           
1               5                   10                  15                

gaa aga gcc acc ctc tcc tgc agg gcc agt cag agt gtt agc ggc tac         96
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Tyr           
            20                  25                  30                    

tta gcc tgg tac caa cag aaa cct ggc cag gct ccc agg ctc ctc atc        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile           
        35                  40                  45                        

tat gat ggg tcc aac agg gcc act ggc atc cca gcc agg ttt agt ggc        192
Tyr Asp Gly Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly           
    50                  55                  60                            

agt ggg tct ggg aca gac ttc act ctc acc atc agc agc ctg gaa cct        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro           
65                  70                  75                  80            

gaa gat ttt gca gtt tat tac tgt cag cat cgt agc aac tgg ccc atg        288
Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg Ser Asn Trp Pro Met           
                85                  90                  95                

tac act ttt ggc cag ggg acc aag ctg gag atc aaa                        324
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys                           
            100                 105                                       


<210>  44
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  44

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Ser Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Gly Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg Ser Asn Trp Pro Met 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  45
<211>  354
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(354)
<223>  NI-307.78C3 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (151)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(321)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  45
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg ggg         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly           
1               5                   10                  15                

acc ctg tcc ctc acc tgc act gtc tct ggt ggc tcc atc agc ggt cgt         96
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Gly Arg           
            20                  25                  30                    

atc tgg tgg agc tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg        144
Ile Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp           
        35                  40                  45                        

att ggg gaa atc tat cat agt ggg agc acc aac tac agc ccg tcc ctc        192
Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Ser Pro Ser Leu           
    50                  55                  60                            

agg ggt cga gtc acc ata tca gtg gac acg tcc aag cag cac ttc tcc        240
Arg Gly Arg Val Thr Ile Ser Val Asp Thr Ser Lys Gln His Phe Ser           
65                  70                  75                  80            

ctg aag atg acc tct gtg acc gcc gcg gac acg gcc atg tat tac tgt        288
Leu Lys Met Thr Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys           
                85                  90                  95                

gtg aga ggc gaa cta gca ctc ggc ttc gac tcc tgg ggc cag gga acc        336
Val Arg Gly Glu Leu Ala Leu Gly Phe Asp Ser Trp Gly Gln Gly Thr           
            100                 105                 110                   

ctg gtc acc gtc tcc tcg                                                354
Leu Val Thr Val Ser Ser                                                   
        115                                                               


<210>  46
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  46

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Gly Arg 
            20                  25                  30          


Ile Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Arg Gly Arg Val Thr Ile Ser Val Asp Thr Ser Lys Gln His Phe Ser 
65                  70                  75                  80  


Leu Lys Met Thr Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Glu Leu Ala Leu Gly Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  47
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)
<223>  NI-307.78C3 variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(108)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(300)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  47
cag tct gcc ctg act cag cct ccc tcc gcg tcc ggg tct cct gga cag         48
Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln           
1               5                   10                  15                

tca gtc acc atc tcc tgc act gga acc agc agt gac gtt ggt ggt tat         96
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr           
            20                  25                  30                    

aac tct gtc tcc tgg tac caa cag cac cca cgc aga gcc ccc aaa ctc        144
Asn Ser Val Ser Trp Tyr Gln Gln His Pro Arg Arg Ala Pro Lys Leu           
        35                  40                  45                        

atg att tat gag gtc agt aag cgg ccc tca ggg gtc cct gat cgc ttc        192
Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe           
    50                  55                  60                            

tct ggc tcc aag tct ggc aac acg gcc tcc ctg acc gtc tct ggc ctc        240
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu           
65                  70                  75                  80            

cag gct gac gat gag gct cat tat tac tgc agc tca tat gca ggc agc        288
Gln Ala Asp Asp Glu Ala His Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser           
                85                  90                  95                

aac aat ttg gtg ttc ggc gga ggg acc atg ctg acc gtc cta                330
Asn Asn Leu Val Phe Gly Gly Gly Thr Met Leu Thr Val Leu                   
            100                 105                 110                   


<210>  48
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  48

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Ser Val Ser Trp Tyr Gln Gln His Pro Arg Arg Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala His Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Asn Leu Val Phe Gly Gly Gly Thr Met Leu Thr Val Leu 
            100                 105                 110 


<210>  49
<211>  387
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(387)
<223>  NI-307.57D5 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(354)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  49
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gca cag ccg ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca ggc tct gga ttc aca ctc agt gat ttt         96
Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Leu Ser Asp Phe           
            20                  25                  30                    

gcc atg agt tgg gtc cgc cgg gct cca ggg aag ggg ctg gaa tgg gtc        144
Ala Met Ser Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tcg tcg ctt act cct tcc ggt cga aat tca ttt tat tca gac tcc gtg        192
Ser Ser Leu Thr Pro Ser Gly Arg Asn Ser Phe Tyr Ser Asp Ser Val           
    50                  55                  60                            

aag ggc cgg ttc acc atc tcc aga gac aat tgg aag aac aca ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Trp Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

tta gaa atg aat ctc ctg aga ccc gag gac acg gcc gtc tat tac tgt        288
Leu Glu Met Asn Leu Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga ccc ggc gcc cct aag aat tct gac agt aaa tat tcc tat gtg        336
Ala Arg Pro Gly Ala Pro Lys Asn Ser Asp Ser Lys Tyr Ser Tyr Val           
            100                 105                 110                   

aga gtg gac ttc cag cac tgg ggc cag ggc acc ctg gtc acc gtc tcc        384
Arg Val Asp Phe Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser           
        115                 120                 125                       

tcg                                                                    387
Ser                                                                       
                                                                          


<210>  50
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Leu Ser Asp Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Leu Thr Pro Ser Gly Arg Asn Ser Phe Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Trp Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Leu Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Ala Pro Lys Asn Ser Asp Ser Lys Tyr Ser Tyr Val 
            100                 105                 110         


Arg Val Asp Phe Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  51
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)
<223>  NI-307.57D5 variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(105)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (274)..(300)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  51
aat ttt atg ctg act cag ccc cac tct gtg tcg gag tct ccg ggg agg         48
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Arg           
1               5                   10                  15                

acg gtt acc att tcg tgc acc cgc agc agc ggc agc att gcc aac aac         96
Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Asn Asn           
            20                  25                  30                    

ttt gtg cag tgg tac cag cac cgc ccg ggc agt gcc ccc acc act ttg        144
Phe Val Gln Trp Tyr Gln His Arg Pro Gly Ser Ala Pro Thr Thr Leu           
        35                  40                  45                        

atc tat gag gat gat cag aga ccc tct ggg gtc cct gat cga ttc tct        192
Ile Tyr Glu Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser           
    50                  55                  60                            

ggc tcc gtc gac agt ttt tcc aac tct gcc tcc ctc acc atc tct ggg        240
Gly Ser Val Asp Ser Phe Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly           
65                  70                  75                  80            

ctg aag act gag gac gag gct gac tac ttc tgt cag tct tat gat aac        288
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Phe Cys Gln Ser Tyr Asp Asn           
                85                  90                  95                

cac aat tgg gtt ttc ggc ggt ggg acc acg ctg acc gtc cta                330
His Asn Trp Val Phe Gly Gly Gly Thr Thr Leu Thr Val Leu                   
            100                 105                 110                   


<210>  52
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  52

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Arg 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Asn Asn 
            20                  25                  30          


Phe Val Gln Trp Tyr Gln His Arg Pro Gly Ser Ala Pro Thr Thr Leu 
        35                  40                  45              


Ile Tyr Glu Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Val Asp Ser Phe Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Phe Cys Gln Ser Tyr Asp Asn 
                85                  90                  95      


His Asn Trp Val Phe Gly Gly Gly Thr Thr Leu Thr Val Leu 
            100                 105                 110 


<210>  53
<211>  375
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(375)
<223>  NI-307.43A11 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (151)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(342)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  53
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg ggg         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly           
1               5                   10                  15                

acc ctg tcc ctc acc tgc gct gtt act ggt ggc tcc atc agt agt agt         96
Thr Leu Ser Leu Thr Cys Ala Val Thr Gly Gly Ser Ile Ser Ser Ser           
            20                  25                  30                    

aat tgg tgg agt tgg gtc cgc cag tcc cca gga aag ggg ctg gag tgg        144
Asn Trp Trp Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp           
        35                  40                  45                        

att gga gaa att cat cat gat gga aat ctc aac tac aat cca ctc ctc        192
Ile Gly Glu Ile His His Asp Gly Asn Leu Asn Tyr Asn Pro Leu Leu           
    50                  55                  60                            

aag agt cga gtc agc atg tca cta gac aga tcc aag aac caa ttt tct        240
Lys Ser Arg Val Ser Met Ser Leu Asp Arg Ser Lys Asn Gln Phe Ser           
65                  70                  75                  80            

ctg aag ctg acc tct gtg aca gcc gcg gac acg gcc gta tat tat tgt        288
Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga tgg gat ttc ttt ttt gat agt tct tat tat att cgt ggt ttt        336
Ala Arg Trp Asp Phe Phe Phe Asp Ser Ser Tyr Tyr Ile Arg Gly Phe           
            100                 105                 110                   

gat ctc tgg ggc cag ggg aca atg gtc acc gtc tct tcg                    375
Asp Leu Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser                       
        115                 120                 125                       


<210>  54
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  54

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Thr Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile His His Asp Gly Asn Leu Asn Tyr Asn Pro Leu Leu 
    50                  55                  60                  


Lys Ser Arg Val Ser Met Ser Leu Asp Arg Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Phe Phe Asp Ser Ser Tyr Tyr Ile Arg Gly Phe 
            100                 105                 110         


Asp Leu Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  55
<211>  327
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(327)
<223>  NI-307.43A11 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(105)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (268)..(297)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  55
gaa acg aca ctc acg cag tct cca ggc acc ctg tct ttg tct cca ggg         48
Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly           
1               5                   10                  15                

gaa aga gtc acc ctc tct tgc agg gcc agt cag agt gtt gac agg aac         96
Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Arg Asn           
            20                  25                  30                    

tat tta gcc tgg tac cag cag aaa cct ggc cag tct ccc agg ctc ctc        144
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu           
        35                  40                  45                        

atc tat agt gca tcc aga agg gcc act ggc atc cca gac agg ttc agt        192
Ile Tyr Ser Ala Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser           
    50                  55                  60                            

ggc agt ggg tct ggg aca gac ttc act ctc acc atc agc aga ctg gag        240
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu           
65                  70                  75                  80            

cct gaa gat ttt gta gtg tat tat tgt cag cag tat ggt ggc tca ccg        288
Pro Glu Asp Phe Val Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Pro           
                85                  90                  95                

ccg atc acc ttc ggc cag ggg aca cga ctg gag att aaa                    327
Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys                       
            100                 105                                       


<210>  56
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  56

Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Arg Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ser Ala Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Val Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Pro 
                85                  90                  95      


Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 


<210>  57
<211>  369
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(369)
<223>  NI-307.3G4 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(336)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  57
cag gtg cag ctg gtg cag tct gga gct gaa ttg aag aag cct ggg gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala           
1               5                   10                  15                

gca gtg aag gtc tcc tgc cag gct tct ggg tac aac ttc ctt agt tat         96
Ala Val Lys Val Ser Cys Gln Ala Ser Gly Tyr Asn Phe Leu Ser Tyr           
            20                  25                  30                    

ggt att aat tgg gtg cga cag atc cct gga caa ggg ctt cag tgg ttg        144
Gly Ile Asn Trp Val Arg Gln Ile Pro Gly Gln Gly Leu Gln Trp Leu           
        35                  40                  45                        

gga tgg atc agc act tat gat ggg acc atg aac tat gac cag aag ccc        192
Gly Trp Ile Ser Thr Tyr Asp Gly Thr Met Asn Tyr Asp Gln Lys Pro           
    50                  55                  60                            

gac aac aga gtc acc gtg acc aca gac aca tcc tcg agt aca gtc tat        240
Asp Asn Arg Val Thr Val Thr Thr Asp Thr Ser Ser Ser Thr Val Tyr           
65                  70                  75                  80            

ttg gaa ctg agg ggc ctg aga tct gac gac acg ggc gtt tat tac tgt        288
Leu Glu Leu Arg Gly Leu Arg Ser Asp Asp Thr Gly Val Tyr Tyr Cys           
                85                  90                  95                

gtg agg gat cgt tgt gct ggt gct ggc tgc tcc cac tcc ctc ggc tat        336
Val Arg Asp Arg Cys Ala Gly Ala Gly Cys Ser His Ser Leu Gly Tyr           
            100                 105                 110                   

tgg ggc cag gga acc ctg gtc acc gtc tcc tcg                            369
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                               
        115                 120                                           


<210>  58
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  58

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ala Val Lys Val Ser Cys Gln Ala Ser Gly Tyr Asn Phe Leu Ser Tyr 
            20                  25                  30          


Gly Ile Asn Trp Val Arg Gln Ile Pro Gly Gln Gly Leu Gln Trp Leu 
        35                  40                  45              


Gly Trp Ile Ser Thr Tyr Asp Gly Thr Met Asn Tyr Asp Gln Lys Pro 
    50                  55                  60                  


Asp Asn Arg Val Thr Val Thr Thr Asp Thr Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Leu Arg Gly Leu Arg Ser Asp Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Arg Cys Ala Gly Ala Gly Cys Ser His Ser Leu Gly Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  59
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-307.3G4 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  59
gac atc cag atg acc cag tct cca tcc gcc ctg tct gca tct gta gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc tct tgc cgg gca agt cag aac att aat acc cag         96
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asn Ile Asn Thr Gln           
            20                  25                  30                    

tta aat tgg tat cag gag aaa cca ggg aaa gcc cca gag tta ttg atc        144
Leu Asn Trp Tyr Gln Glu Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile           
        35                  40                  45                        

tat ggt gca ttc aat ttg caa agt ggg gcc cca tca acg ttc agt ggc        192
Tyr Gly Ala Phe Asn Leu Gln Ser Gly Ala Pro Ser Thr Phe Ser Gly           
    50                  55                  60                            

agt ggt tct ggg aca gat ttc act ctc acc atc acc agt ctg caa cct        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro           
65                  70                  75                  80            

gaa gat ttt gca agt tac tac tgt caa cag ggt ttc cat gcc ccg tac        288
Glu Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Gly Phe His Ala Pro Tyr           
                85                  90                  95                

act ttt ggc cgg ggg acc aaa gtg gat atc aaa                            321
Thr Phe Gly Arg Gly Thr Lys Val Asp Ile Lys                               
            100                 105                                       


<210>  60
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  60

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asn Ile Asn Thr Gln 
            20                  25                  30          


Leu Asn Trp Tyr Gln Glu Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Phe Asn Leu Gln Ser Gly Ala Pro Ser Thr Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Gly Phe His Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Arg Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  61
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(360)
<223>  NI-307.61D11 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(327)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  61
gag gtg cag ctg gtg cag tct ggg gct gag gtg aag aaa cct ggg gcc         48
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtc tcc tgc aag act tct gga tac acc ttc atc ggc cac         96
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ile Gly His           
            20                  25                  30                    

tac atg cag tgg gtg cga cag gtc cct gga caa ggg ttt gag tgg atg        144
Tyr Met Gln Trp Val Arg Gln Val Pro Gly Gln Gly Phe Glu Trp Met           
        35                  40                  45                        

gga tgg atc aac cct aac acc ggt act aca aag tat gca ctg aag ttt        192
Gly Trp Ile Asn Pro Asn Thr Gly Thr Thr Lys Tyr Ala Leu Lys Phe           
    50                  55                  60                            

aag gac cgg gtc acc gtg acc agg gac acg tcc aca gca aca gtg tac        240
Lys Asp Arg Val Thr Val Thr Arg Asp Thr Ser Thr Ala Thr Val Tyr           
65                  70                  75                  80            

atg gag ttt cat gga ctg aca tct gac gac acg gcc gtg tat tac tgc        288
Met Glu Phe His Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gcc agt gcc tat caa ctg gca aac tat gac tac tgg ggc cag        336
Ala Arg Ala Ser Ala Tyr Gln Leu Ala Asn Tyr Asp Tyr Trp Gly Gln           
            100                 105                 110                   

gga acc ctg gtc acc gtc tcc tcg                                        360
Gly Thr Leu Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  62
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  62

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ile Gly His 
            20                  25                  30          


Tyr Met Gln Trp Val Arg Gln Val Pro Gly Gln Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Thr Gly Thr Thr Lys Tyr Ala Leu Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Val Thr Arg Asp Thr Ser Thr Ala Thr Val Tyr 
65                  70                  75                  80  


Met Glu Phe His Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ser Ala Tyr Gln Leu Ala Asn Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  63
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(336)
<223>  NI-307.61D11 variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(108)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(306)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  63
cag tct gcc ctg act cag cct gcc tcc gtg tct ggg tct cct gga cag         48
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln           
1               5                   10                  15                

tcg atc acc atc tcc tgc gct gga acc agc aat gac gtt ggt gat gat         96
Ser Ile Thr Ile Ser Cys Ala Gly Thr Ser Asn Asp Val Gly Asp Asp           
            20                  25                  30                    

gac ttt gtc tcc tgg tac caa cac caa cca ggg aaa gcc ccc aga ctc        144
Asp Phe Val Ser Trp Tyr Gln His Gln Pro Gly Lys Ala Pro Arg Leu           
        35                  40                  45                        

atg att tat gag gtc act aat cgg ccc tca ggg gtt tct act cgc ttc        192
Met Ile Tyr Glu Val Thr Asn Arg Pro Ser Gly Val Ser Thr Arg Phe           
    50                  55                  60                            

tct ggc tcc aag tct ggc aac acg gcc tcc ctg acc atc tct gga ctc        240
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu           
65                  70                  75                  80            

cag gct gaa gac gag ggt gat tat tac tgt atg tca tat aca aag aac        288
Gln Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Met Ser Tyr Thr Lys Asn           
                85                  90                  95                

agc gct ctc ggt tat gtc ttc gga ggt ggg acc aag gtc acc gtc cta        336
Ser Ala Leu Gly Tyr Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu           
            100                 105                 110                   


<210>  64
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  64

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ala Gly Thr Ser Asn Asp Val Gly Asp Asp 
            20                  25                  30          


Asp Phe Val Ser Trp Tyr Gln His Gln Pro Gly Lys Ala Pro Arg Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Thr Asn Arg Pro Ser Gly Val Ser Thr Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Met Ser Tyr Thr Lys Asn 
                85                  90                  95      


Ser Ala Leu Gly Tyr Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110         


<210>  65
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(363)
<223>  NI-307.24F3 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(330)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  65
cag gtg cag ctg cag gag tcg ggg gga ggc gtg gtc cag cct ggg agg         48
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg           
1               5                   10                  15                

tcc cta aga ctc tcc tgt gca gcg tca gga ttc agc ttc aat agg tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Arg Tyr           
            20                  25                  30                    

ggc atg cac tgg gtc cgc cag gct cca ggc aag ggg ctg gag tgg ttg        144
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu           
        35                  40                  45                        

gca gtc atc tca aat gat gga gtc aat aca cac tac gca gac tcc gtg        192
Ala Val Ile Ser Asn Asp Gly Val Asn Thr His Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc aga gac aat tcc aag agc acg ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr           
65                  70                  75                  80            

ttg caa gcg agc agc ctg aga gtt gag gac acg gct gtg tat tac tgt        288
Leu Gln Ala Ser Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg ggg tat tac tat ggt tcg ggg act tca ctt ttc ttc tac tgg ggc        336
Ala Gly Tyr Tyr Tyr Gly Ser Gly Thr Ser Leu Phe Phe Tyr Trp Gly           
            100                 105                 110                   

cag gga acc ctg gtc acc gtc tcc tcg                                    363
Gln Gly Thr Leu Val Thr Val Ser Ser                                       
        115                 120                                           


<210>  66
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  66

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Arg Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ala Val Ile Ser Asn Asp Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Ala Ser Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Tyr Tyr Tyr Gly Ser Gly Thr Ser Leu Phe Phe Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  67
<211>  339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(339)
<223>  NI-307.24F3 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(120)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (166)..(186)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (283)..(309)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  67
gaa att gtg ctg act cag tct cca gac tcc ctg gct gtg tct ctg ggc         48
Glu Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly           
1               5                   10                  15                

gag agg gcc acc atc aac tgc aag tcc agc cag act gtt tta tac agc         96
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Thr Val Leu Tyr Ser           
            20                  25                  30                    

tcc aac aat cag aac tac tta gct tgg tac cag cag aaa cca gga cag        144
Ser Asn Asn Gln Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln           
        35                  40                  45                        

cct cct aag ctg ctc ctt tac tgg gca tct acc cgg gaa tcc ggg gtc        192
Pro Pro Lys Leu Leu Leu Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val           
    50                  55                  60                            

cct gac cgg ttc agt ggc agc ggg tct ggg aca gat ttc act ctc acc        240
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr           
65                  70                  75                  80            

atc agc agc ctg cag cct gaa gat gtg gca gtt tat tac tgt cag caa        288
Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln           
                85                  90                  95                

tat tat act gct ccg tac act ttt ggc cag ggg acc aag gtg gag atc        336
Tyr Tyr Thr Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile           
            100                 105                 110                   

aaa                                                                    339
Lys                                                                       
                                                                          


<210>  68
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  68

Glu Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Thr Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Gln Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Leu Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Thr Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  69
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(363)
<223>  NI-307.18E12 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(99)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(195)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (292)..(330)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  69
cag gtg cag cta cag cag tgg ggc gca ggg ctg ttg aag cct tcg gag         48
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu           
1               5                   10                  15                

acc ctg tcc ctc acg tgc gct gta tat ggt gac tcc ttc agt ggt ttc         96
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Asp Ser Phe Ser Gly Phe           
            20                  25                  30                    

ttc tgg gcc tgg atc cgc cag act cca ggg acg ggg ctg gag tgg att        144
Phe Trp Ala Trp Ile Arg Gln Thr Pro Gly Thr Gly Leu Glu Trp Ile           
        35                  40                  45                        

ggg gaa atc caa cat ggt gga agc ccc acg tac aat ccg tcg ttc gag        192
Gly Glu Ile Gln His Gly Gly Ser Pro Thr Tyr Asn Pro Ser Phe Glu           
    50                  55                  60                            

agt cga ctc acc ata tcg act gac gcg tct aag agt caa gtc tct ctt        240
Ser Arg Leu Thr Ile Ser Thr Asp Ala Ser Lys Ser Gln Val Ser Leu           
65                  70                  75                  80            

aaa atg aca tct gtg acc gtc acg gac acg gct ata tat tat tgt gcg        288
Lys Met Thr Ser Val Thr Val Thr Asp Thr Ala Ile Tyr Tyr Cys Ala           
                85                  90                  95                

agg tgt atc cgg ggt aaa tat ggt tcg ggc agt ttg cag ttg tgg agt        336
Arg Cys Ile Arg Gly Lys Tyr Gly Ser Gly Ser Leu Gln Leu Trp Ser           
            100                 105                 110                   

cag ggc acc ctg gtc acc gtc tcc tcg                                    363
Gln Gly Thr Leu Val Thr Val Ser Ser                                       
        115                 120                                           


<210>  70
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  70

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Asp Ser Phe Ser Gly Phe 
            20                  25                  30          


Phe Trp Ala Trp Ile Arg Gln Thr Pro Gly Thr Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Gln His Gly Gly Ser Pro Thr Tyr Asn Pro Ser Phe Glu 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Thr Asp Ala Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Thr Ser Val Thr Val Thr Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Cys Ile Arg Gly Lys Tyr Gly Ser Gly Ser Leu Gln Leu Trp Ser 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  71
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-307.18E12 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  71
gac atc cag ttg acc cag tct cca tcc ttc ctg tct gca tct gtg gga         48
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgc cgg gcc agt cag gac att aat tat cat         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Asn Tyr His           
            20                  25                  30                    

tta gcc tgg tat cgg cag aag cca gga aaa gcc cct gac ctc ctg atc        144
Leu Ala Trp Tyr Arg Gln Lys Pro Gly Lys Ala Pro Asp Leu Leu Ile           
        35                  40                  45                        

cat agt gcg cac act ttg cac att ggg gtc tca tcg agg ttc agc ggc        192
His Ser Ala His Thr Leu His Ile Gly Val Ser Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggg aca gaa ttc act ctc aca atc cac acc ttg cag cct        240
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile His Thr Leu Gln Pro           
65                  70                  75                  80            

gaa gat ttt gca acc tat tat tgt cac cag cct aaa act ttt cct ccc        288
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Pro Lys Thr Phe Pro Pro           
                85                  90                  95                

act ttc ggc ggc ggg acc aaa gtg gat atc aaa                            321
Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys                               
            100                 105                                       


<210>  72
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  72

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Asn Tyr His 
            20                  25                  30          


Leu Ala Trp Tyr Arg Gln Lys Pro Gly Lys Ala Pro Asp Leu Leu Ile 
        35                  40                  45              


His Ser Ala His Thr Leu His Ile Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile His Thr Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Pro Lys Thr Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  73
<211>  381
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(381)
<223>  NI-307.20F5 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(348)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  73
gag gtg cag ctg gtg gag tct ggg gga ggc gtg gtc cag cct ggg acg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Thr           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcg tct ggg ttt agt ttc aat aaa tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Lys Tyr           
            20                  25                  30                    

ggc gta cac tgg gtc cgc cag gct cct ggc aag ggg ctg gag tgg gtg        144
Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

gcg aat att tgg tat gat gga act aat cct ttt tat gca gac ttc gtg        192
Ala Asn Ile Trp Tyr Asp Gly Thr Asn Pro Phe Tyr Ala Asp Phe Val           
    50                  55                  60                            

aag ggc cgg ttc gtc atc tcc aga gac act tcc aag aac acg att tat        240
Lys Gly Arg Phe Val Ile Ser Arg Asp Thr Ser Lys Asn Thr Ile Tyr           
65                  70                  75                  80            

ctg caa atg aac aga ctg agg gcc gag gac acg gct gtg tat tat tgt        288
Leu Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gat gca ttt tgt ggt gga gac tgt tat ggt ggc cta tta cac        336
Ala Arg Asp Ala Phe Cys Gly Gly Asp Cys Tyr Gly Gly Leu Leu His           
            100                 105                 110                   

ggt ttg gac gtc tgg ggc caa ggg acc acg gtc acc gtc tcc tcg            381
Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser               
        115                 120                 125                       


<210>  74
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Thr 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Lys Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Trp Tyr Asp Gly Thr Asn Pro Phe Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Val Ile Ser Arg Asp Thr Ser Lys Asn Thr Ile Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Phe Cys Gly Gly Asp Cys Tyr Gly Gly Leu Leu His 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  75
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(333)
<223>  NI-307.20F5 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(117)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (163)..(183)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (280)..(303)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  75
gat gtt gtg atg act cag tct cca ctc tcc ctg ccc gtc act cct gga         48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly           
1               5                   10                  15                

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctg cat agt         96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser           
            20                  25                  30                    

aat ggg ctc aat tat tta gat tgg tac ctg cag aag cca gga cag tct        144
Asn Gly Leu Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser           
        35                  40                  45                        

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc ccc ggg gtc cct        192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Pro Gly Val Pro           
    50                  55                  60                            

gac agg ttc agt ggc agt gga tca ggc aca gat ttt aca ctg aaa atc        240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile           
65                  70                  75                  80            

agc aga gtg gag gct gag gat gtt ggg gtt tat tac tgc ttg caa gct        288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Ala           
                85                  90                  95                

cta caa act ccg gcg ttc ggc cag ggg acc aag gtg gaa atc aaa            333
Leu Gln Thr Pro Ala Phe Gly Gln Gly Thr Lys Val Glu Ile Lys               
            100                 105                 110                   


<210>  76
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  76

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Leu Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Pro Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Ala Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  77
<211>  369
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(369)
<223>  NI-307.58C7 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(336)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  77
gag gtg cag ctg gtg gag tcc ggg gga ggc ttg gtc aag cct gga ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttc agt gac tac         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr           
            20                  25                  30                    

tac gtc aac tgg atc cgc cag gct cca ggg aag ggg ctg gag tgg gtt        144
Tyr Val Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

gca tgc att agt agt agt ggt cgt acc ata cac tac gca gac tcc gtg        192
Ala Cys Ile Ser Ser Ser Gly Arg Thr Ile His Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc agg gac aac gcc aag aac tca ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga gcc gag gac acg gcc ttt tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Phe Tyr Tyr Cys           
                85                  90                  95                

gcg aga gac ctg gac aaa gca gca act ggc aga ccc tac ttt gac tac        336
Ala Arg Asp Leu Asp Lys Ala Ala Thr Gly Arg Pro Tyr Phe Asp Tyr           
            100                 105                 110                   

tgg ggc cag gga acc ctg gtc acc gtc tcc tcg                            369
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                               
        115                 120                                           


<210>  78
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  78

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Val Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Cys Ile Ser Ser Ser Gly Arg Thr Ile His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Asp Lys Ala Ala Thr Gly Arg Pro Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  79
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)
<223>  NI-307.58C7 variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(105)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (268)..(300)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  79
cag tct gtg ctg act cag cca ccc tca gcg tct ggg acc ccc ggg cag         48
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln           
1               5                   10                  15                

agg gtc acc atc tct tgt tct gga agc agc tcc aac atc gga ggt aat         96
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn           
            20                  25                  30                    

gct gtg aac tgg ttc caa cag ctc cca gga acg gcc ccc aaa ctc ctc        144
Ala Val Asn Trp Phe Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu           
        35                  40                  45                        

atc tat ggt aat act cag cgg ccc tca ggg gtc cct gac cga ttc tct        192
Ile Tyr Gly Asn Thr Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser           
    50                  55                  60                            

ggc tcc aag tct ggc acc tca gcc tcc ctg gcc atc agt ggg ctc cag        240
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln           
65                  70                  75                  80            

tct gaa gat gag act aat tat tac tgt gca gca tgg gat gac agc ctg        288
Ser Glu Asp Glu Thr Asn Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu           
                85                  90                  95                

aat ggt gtg gta ttc ggc gga ggg acc aag ctg acc gtc cta                330
Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                   
            100                 105                 110                   


<210>  80
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  80

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn 
            20                  25                  30          


Ala Val Asn Trp Phe Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Thr Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Thr Asn Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  81
<211>  378
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(378)
<223>  NI-307.105C7 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(345)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  81
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gta cag cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc tcc ttt gga ttc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Gly Phe Tyr           
            20                  25                  30                    

gcc atg aac tgg gtc cgc cag gct cca ggg aag ggg ctg gag tac gtc        144
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val           
        35                  40                  45                        

tca ggt gtc agt ggt ggt ggt ggt agc aca tac tac gca gac tcc gtg        192
Ser Gly Val Ser Gly Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aag agc ctg aga gcc gag gac acg gcc ata tat tac tgt        288
Leu Gln Met Lys Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys           
                85                  90                  95                

gcg aaa gat cag tct tac tgt agt ggt ggt agc tgc cac ccc tac tac        336
Ala Lys Asp Gln Ser Tyr Cys Ser Gly Gly Ser Cys His Pro Tyr Tyr           
            100                 105                 110                   

tta gac tac tgg ggc cag gga acc ctg gtc acc gtc tcc tcg                378
Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                   
        115                 120                 125                       


<210>  82
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  82

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Gly Phe Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ser Gly Val Ser Gly Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Lys Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gln Ser Tyr Cys Ser Gly Gly Ser Cys His Pro Tyr Tyr 
            100                 105                 110         


Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  83
<211>  327
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(327)
<223>  NI-307.105C7 variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(99)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (145)..(165)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (262)..(297)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  83
tcc tat gtg ctg act cag cca ccc tcg gtg tcc gtg gcc cca gga cag         48
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln           
1               5                   10                  15                

acg gcc agg att acc tgt ggg gga aat aac att gga agt aaa agt gtg         96
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val           
            20                  25                  30                    

cac tgg tac cag cag aag cca ggc cag gcc cct gtg gtg gtc gtc tat        144
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Val Tyr           
        35                  40                  45                        

gat gat agc ggc cgg ccc tca ggt atc cct gag cga ttc tct ggc tcc        192
Asp Asp Ser Gly Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser           
    50                  55                  60                            

aat tct ggg aac acg gcc acc ctg acc atc agc agg gtc gaa gcc ggg        240
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly           
65                  70                  75                  80            

gat gag gcc gac tat tac tgt cag gtg tgg gat agt agt agt gat cat        288
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His           
                85                  90                  95                

cct tat gtc ttc gga act ggg acc aag gtc acc gtc cta                    327
Pro Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu                       
            100                 105                                       


<210>  84
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  84

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Gly Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


Pro Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 


<210>  85
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope recognized by NI-307.11G6 antibody


<220>
<221>  PEPTIDE
<222>  (1)..(7)
<223>  Epitope of NI-307.11G6 antibody, aa 333 to aa 339

<400>  85

Leu Pro Gly Asp Pro Asp Met 
1               5           


<210>  86
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope recognized by NI-307.13G4 antibody


<220>
<221>  PEPTIDE
<222>  (1)..(7)
<223>  Epitope of NI-307.13G4 antibody, aa124 to aa130

<220>
<221>  PEPTIDE
<222>  (1)..(7)
<223>  Epitope of NI-307.13G4 antibody, aa 124 to aa 130

<400>  86

Gly Gln Ala Thr His Asp Asn 
1               5           


<210>  87
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope recognized by NI-307.13G4 antibody


<220>
<221>  PEPTIDE
<222>  (1)..(12)
<223>  Epitope of NI-307.13G4 antibody, aa 340 to aa 351

<400>  87

Met Arg Tyr Val Asp Lys Tyr Gly Gln Leu Gln Thr 
1               5                   10          


<210>  88
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope recognized by NI-307.61D11 antibody


<220>
<221>  PEPTIDE
<222>  (1)..(11)
<223>  Epitope of NI-307.61D11 antibody, aa 325 to aa 335

<400>  88

Arg Val Phe Glu Gly Thr Glu Glu Leu Pro Gly 
1               5                   10      


<210>  89
<211>  369
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(369)
<223>  NI-307.98D3 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  Complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(195)
<223>  Complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(336)
<223>  Complementarity determining region (CDR) VH-CDR3

<400>  89
gag gtg cag ctg gtg gag tct ggg gga ggc gtg gtc cag cct ggg agg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttc agc agc tcc         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser           
            20                  25                  30                    

gct atg cac tgg gtc cgc cag gct cca ggc aag ggg ctg gag tgg gtg        144
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

gca gtt ata tca tat gat ggg aat aat caa tta tac gca gac tcc gtg        192
Ala Val Ile Ser Tyr Asp Gly Asn Asn Gln Leu Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga tta acc atc tcc aga gac aat tcc aag aat gca ctg tat        240
Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala Leu Tyr           
65                  70                  75                  80            

ctt caa ctg aac agc ctg aga act gag gac acg gct gtt tat ttc tgt        288
Leu Gln Leu Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Phe Cys           
                85                  90                  95                

gcg aga gat ggg ggt gga tac agc ttt ggc act tac ttc ttt gac ttc        336
Ala Arg Asp Gly Gly Gly Tyr Ser Phe Gly Thr Tyr Phe Phe Asp Phe           
            100                 105                 110                   

tgg ggc cag gga acc ctg gtc acc gtc tcc tcg                            369
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                               
        115                 120                                           


<210>  90
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  90

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Asn Asn Gln Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Gly Gly Tyr Ser Phe Gly Thr Tyr Phe Phe Asp Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  91
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-307.98D3 variable kappa-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  Complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  Complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  Complementarity determining region (CDR) VK-CDR3

<400>  91
gac atc cag atg acc cag tct cca tcc tcc ctg tct gca tct gta gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gag aga gtc acc atc act tgt cgg gca agt cag agg att agc aac tat         96
Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Arg Ile Ser Asn Tyr           
            20                  25                  30                    

tta aat tgg tat cag cag aaa cca ggg aaa gcc cct aag ctc ctg atc        144
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile           
        35                  40                  45                        

tat gct gca tcc act ttg caa agt ggg gtc cca tca agg ttc agt ggc        192
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggg aca gat ttc act ctc acc atc agc agt ctg caa cct        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gaa gat ttt gca act tac tac tgt caa cag agt tac agt agt ccc ccc        288
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Pro Pro           
                85                  90                  95                

act ttc ggc cct ggg acc aaa gtg gat atc aaa                            321
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys                               
            100                 105                                       


<210>  92
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  92

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Arg Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Pro Pro 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  93
<211>  384
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(384)
<223>  NI-307.72F7 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  Complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  Complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(351)
<223>  Complementarity determining region (CDR) VH-CDR2

<400>  93
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gta cag cct gga ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttc agt agt tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

gaa atg aac tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg att        144
Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile           
        35                  40                  45                        

tca tac att agt agt cgt ggg agt acc ata cac tac gca gac tct gtg        192
Ser Tyr Ile Ser Ser Arg Gly Ser Thr Ile His Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc aga gac gac gcc aag aac tca ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga gcc gag gac acg gct att tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys           
                85                  90                  95                

gcg aga gat cgg tac gat ttc tgg agt ggt tgc atc aag ggg tgc tac        336
Ala Arg Asp Arg Tyr Asp Phe Trp Ser Gly Cys Ile Lys Gly Cys Tyr           
            100                 105                 110                   

tac ggc atg gac gtc tgg ggc caa ggg tcc acg gtc acc gtc tcc tcg        384
Tyr Gly Met Asp Val Trp Gly Gln Gly Ser Thr Val Thr Val Ser Ser           
        115                 120                 125                       


<210>  94
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  94

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Tyr Ile Ser Ser Arg Gly Ser Thr Ile His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Tyr Asp Phe Trp Ser Gly Cys Ile Lys Gly Cys Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Ser Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  95
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-307.72F7 variable kappa-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(105)
<223>  Complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  Complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (268)..(291)
<223>  Complementarity determining region (CDR) VK-CDR3

<400>  95
gaa att gtg ttg acg cag tct cca ggc acc ctg tct ttg tct cca ggg         48
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly           
1               5                   10                  15                

caa aga gcc acc ctc tcc tgc agg gcc agt cag agc att agc agc agc         96
Gln Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Ser           
            20                  25                  30                    

tac ttg gcc tgg tac cag cag aga cgt ggc cag gct ccc agg ctc ctc        144
Tyr Leu Ala Trp Tyr Gln Gln Arg Arg Gly Gln Ala Pro Arg Leu Leu           
        35                  40                  45                        

atc tat ggt gca tcc agc agg gcc act ggc atc cca gac agg ttc agt        192
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser           
    50                  55                  60                            

ggc agt ggg tct ggg aca gac ttc act ctc acc atc agc aga ctg gag        240
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu           
65                  70                  75                  80            

cct gaa gat ttt gca gtg tat tac tgt cag cac tat ggt acc aca ctg        288
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Thr Thr Leu           
                85                  90                  95                

acg ttc ggc caa ggg acc aaa gtg gat atc aaa                            321
Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys                               
            100                 105                                       


<210>  96
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  96

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Arg Arg Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Thr Thr Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  97
<211>  378
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(378)
<223>  NI-307.45E10 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  Complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  Complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(345)
<223>  Complementarity determining region (CDR) VH-CDR3

<400>  97
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gtg cag cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc tcc ttt aga ttc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Arg Phe Tyr           
            20                  25                  30                    

gcc atg aac tgg gtc cgc cag gct cca ggg aag ggg ctg gag tac gtc        144
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val           
        35                  40                  45                        

tca ggt atc agt ggt ggt ggt ggt act aca tac tac gca gac tcc gtg        192
Ser Gly Ile Ser Gly Gly Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acc ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aag agc ctg aga gcc gag gac acg gcc ata tat tac tgt        288
Leu Gln Met Lys Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys           
                85                  90                  95                

gcg aaa gat cag tct tac tgt agt ggt gct ggc tgc cac ccc tac tac        336
Ala Lys Asp Gln Ser Tyr Cys Ser Gly Ala Gly Cys His Pro Tyr Tyr           
            100                 105                 110                   

tta gac tac tgg ggc cag gga acc ctg gtc acc gtc tcc tcg                378
Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                   
        115                 120                 125                       


<210>  98
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  98

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Arg Phe Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Gly Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Lys Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gln Ser Tyr Cys Ser Gly Ala Gly Cys His Pro Tyr Tyr 
            100                 105                 110         


Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  99
<211>  327
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(327)
<223>  NI-307.45E10 variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(99)
<223>  Complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (145)..(165)
<223>  Complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (262)..(297)
<223>  Complementarity determining region (CDR) VL-CDR3

<400>  99
tcc tat gtg ctg act cag cca ccc tcg gtg tcc gtg gcc cca gga cag         48
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln           
1               5                   10                  15                

acg gcc agg att acc tgt ggg gga aat aac att gga agt aaa agt gtg         96
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val           
            20                  25                  30                    

cac tgg tac cag cag aag cca ggc cag gcc cct gtg gtg gtc gtc tat        144
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Val Tyr           
        35                  40                  45                        

gat gat agt ggc cgg ccc tca ggg atg cct gag cga ttc tct ggc tcc        192
Asp Asp Ser Gly Arg Pro Ser Gly Met Pro Glu Arg Phe Ser Gly Ser           
    50                  55                  60                            

aac tct ggg aac acg gcc acc ctg acc atc agc agg gtc gaa gcc ggg        240
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly           
65                  70                  75                  80            

gat gag gcc gac tat tac tgt cag gtg tgg gat agt agt agt gat cat        288
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His           
                85                  90                  95                

ctt tat gtc ttc gga act ggg acc aag gtc acc gtc cta                    327
Leu Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu                       
            100                 105                                       


<210>  100
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  100

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Gly Arg Pro Ser Gly Met Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


Leu Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 


<210>  101
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(363)
<223>  NI-307.72F10 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  Complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(192)
<223>  Complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(330)
<223>  Complementarity determining region (CDR) VH-CDR3

<400>  101
gag gtg cag ctg gtg gag tct ggg gga ggc gtg gta cag cct ggc agg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca acc tct gga ttc acc ttt gat gat tat         96
Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Asp Asp Tyr           
            20                  25                  30                    

gcc atg cac tgg gtc cgg caa gct cca ggg aag ggc ctg gag tgg gtc        144
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca ggt ctg act tgg agt agt agt ggc gtt ggc tat gcc gac tct gtg        192
Ser Gly Leu Thr Trp Ser Ser Ser Gly Val Gly Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc aga gac aac gcc aag aac tcc ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agt ctg aga gct gag gac acg gcc ttg tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys           
                85                  90                  95                

gca aaa ggt tcc ggg gag tgg cta cga tta gga caa gac tac tgg ggc        336
Ala Lys Gly Ser Gly Glu Trp Leu Arg Leu Gly Gln Asp Tyr Trp Gly           
            100                 105                 110                   

cag gga acc ctg gtc acc gtc tcc tcg                                    363
Gln Gly Thr Leu Val Thr Val Ser Ser                                       
        115                 120                                           


<210>  102
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  102

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Leu Thr Trp Ser Ser Ser Gly Val Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ser Gly Glu Trp Leu Arg Leu Gly Gln Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  103
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(333)
<223>  NI-307.72F10  variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(108)
<223>  Complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  Complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(303)
<223>  Complementarity determining region (CDR) VL-CDR3

<400>  103
cag tct gtg ctg act cag cca ccc tca gtc tct ggg acc cca ggg cag         48
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln           
1               5                   10                  15                

agg gtc acc atc tcc tgc act ggg agc agc tcc aac atc ggg gca ggt         96
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly           
            20                  25                  30                    

tat gat gta cac tgg tac cag cag ctt cca gga aca gcc ccc aaa ctc        144
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu           
        35                  40                  45                        

ctc atc tat gat aac agt aat cgg ccc tca ggg gtc cct gac cga ttc        192
Leu Ile Tyr Asp Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe           
    50                  55                  60                            

tct ggc tcc aag tct ggc acc tca gcc tcc ctg gcc atc act ggg ctc        240
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu           
65                  70                  75                  80            

cag gct gag gat gag gct cat tat tac tgc cag tcc ttt gac agc agc        288
Gln Ala Glu Asp Glu Ala His Tyr Tyr Cys Gln Ser Phe Asp Ser Ser           
                85                  90                  95                

ctg agt ggt tcg gtt ttc ggc gga ggg acc aag ctg gcc gtc cta            333
Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Ala Val Leu               
            100                 105                 110                   


<210>  104
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  104

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala His Tyr Tyr Cys Gln Ser Phe Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Ala Val Leu 
            100                 105                 110     


<210>  105
<211>  354
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(354)
<223>  NI-307.56A8 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  Complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  Complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(321)
<223>  Complementarity determining region (CDR) VH-CDR3

<400>  105
gag gtg cag ctg gtg gag tct ggg gga ggc ctg gtc aag cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttc agt agc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

aga atg aac tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Arg Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca tcc att agt agt agc agt agt tac ata tac tat gga gac tca gtg        192
Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Gly Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc aga gac aac gcc aag aac tca ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr           
65                  70                  75                  80            

ctg caa atg agc agc ctg aga gcc gag gac acg gct gtg tat tac tgt        288
Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga tac gcg cac gac tgg aac att gac tac tgg ggc cag gga acc        336
Ala Arg Tyr Ala His Asp Trp Asn Ile Asp Tyr Trp Gly Gln Gly Thr           
            100                 105                 110                   

ctg gtc acc gtc tcc tcg                                                354
Leu Val Thr Val Ser Ser                                                   
        115                                                               


<210>  106
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  106

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Arg Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Ala His Asp Trp Asn Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  107
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)
<223>  NI-307.56A8 variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(105)
<223>  Complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  Complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (268)..(300)
<223>  Complementarity determining region (CDR) VL-CDR3

<400>  107
cag tct gtg ctg act cag cca ccc tca gcg tct ggg acc ccc ggg cag         48
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln           
1               5                   10                  15                

agg gtc acc atc tct tgt tct gga agc agc tcc aac atc gga agt aat         96
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn           
            20                  25                  30                    

act gta aac tgg tac cag cag ctc cca gga acg gcc ccc aaa ctc ctc        144
Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu           
        35                  40                  45                        

atc tat agt aat agt cag cgg ccc tca ggg gtc cct gac cga ttc tct        192
Ile Tyr Ser Asn Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser           
    50                  55                  60                            

ggc tcc aag tct ggc acc tca gcc tcc ctg gcc atc agt ggg ctc cag        240
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln           
65                  70                  75                  80            

tct gag gat gag gct gat tat tac tgt gca gca tgg gat gac agc ctg        288
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu           
                85                  90                  95                

aat ggt tgg gtg ttc ggc gga ggg acc aag ctg acc gtc cta                330
Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                   
            100                 105                 110                   


<210>  108
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  108

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  109
<211>  381
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(381)
<223>  NI-307.27C11 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (151)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(348)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  109
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg ggg         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly           
1               5                   10                  15                

acc ctg tcc ctc acc tgc gct gtc tct ggt gac tct atc agc agt agt         96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Asp Ser Ile Ser Ser Ser           
            20                  25                  30                    

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag ggg ctg gag tgg        144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp           
        35                  40                  45                        

att ggg gag atc tat cat agt ggg ggc acc aag tac aac ccg tcc ctc        192
Ile Gly Glu Ile Tyr His Ser Gly Gly Thr Lys Tyr Asn Pro Ser Leu           
    50                  55                  60                            

aag agt cga gtc acc att tca gta gac aag tcc aag aat cac ttc tcc        240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn His Phe Ser           
65                  70                  75                  80            

ctg aag ctg agg tct gtg acc gcc gcg gac acg gcc gtg tat tat tgt        288
Leu Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga aat agg tgg ttc gac aat aac cgg ggg ggc tac tac tac tac        336
Ala Arg Asn Arg Trp Phe Asp Asn Asn Arg Gly Gly Tyr Tyr Tyr Tyr           
            100                 105                 110                   

ggc atg gac gtc tgg ggc caa ggg acc acg gtc acc gtc tcc tcg            381
Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser               
        115                 120                 125                       


<210>  110
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  110

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Asp Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Gly Thr Lys Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn His Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Arg Trp Phe Asp Asn Asn Arg Gly Gly Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  111
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-307.27C11 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  111
gac atc cag atg acc cag tct cca tcc tcc ctg tct gca tct gtg gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgc cgg gca agt cag ggc atc agt agt tat         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr           
            20                  25                  30                    

tta aat tgg tat cag cag aaa cca ggg aaa gcc cct aaa ctc ctg atc        144
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile           
        35                  40                  45                        

tct gct aca tcc gat ttg caa agt ggg gtc cca tca agg ttc agt ggc        192
Ser Ala Thr Ser Asp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggg aca gat ttc act ctc acc atc agc agt ctg caa cct        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gaa gat ttt gct act tac tac tgt caa cag agt tac agt acc ccg tac        288
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr           
                85                  90                  95                

act ttt ggc cag ggg acc aag ctg gag atc aaa                            321
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys                               
            100                 105                                       


<210>  112
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  112

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Ala Thr Ser Asp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  113
<211>  369
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(369)
<223>  NI-307.47B11  variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(336)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  113
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gtc aag cct gga ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttc agt gac tac         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr           
            20                  25                  30                    

tac atg aac tgg atc cgc cag gct cca ggg aag ggg ctg gag tgg ctt        144
Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu           
        35                  40                  45                        

tca tgc att agt agt agt ggt aat acc att tac tac gca gac tct gtg        192
Ser Cys Ile Ser Ser Ser Gly Asn Thr Ile Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc agg gac aac gcc aag aac tca ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga gcc gag gac acg gcc gta tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gat ttg gac aaa gca gca act ggc aga ccc tac ttt gac tac        336
Ala Arg Asp Leu Asp Lys Ala Ala Thr Gly Arg Pro Tyr Phe Asp Tyr           
            100                 105                 110                   

tgg ggc cag gga acc ctg gtc acc gtc tcc tcg                            369
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                               
        115                 120                                           


<210>  114
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  114

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Gly Asn Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Asp Lys Ala Ala Thr Gly Arg Pro Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  115
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)
<223>  NI-307.47B11 variable L-light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(105)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (268)..(300)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  115
cag tct gtg ctg act cag cca ccc tca gcg tct ggg acc ccc ggg cag         48
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln           
1               5                   10                  15                

agg gtc acc atc tct tgt tct gga agc agc tcc aac atc gga agt aat         96
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn           
            20                  25                  30                    

act gta aac tgg tac cag cag ctc cca gga acg gcc ccc aaa ctc ctc        144
Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu           
        35                  40                  45                        

atc tat agt aat aat cag cgg ccc tca ggg gtc cct gac cga ttc tct        192
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser           
    50                  55                  60                            

ggc tcc agg tct ggc acc tca gcc tcc ctg gcc atc agt gga ctc cag        240
Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln           
65                  70                  75                  80            

tct gag gat gag gct gat tat tac tgt gca gca tgg gat gac agc ctg        288
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu           
                85                  90                  95                

aat ggt gtg gta ttc ggc gga ggg acc aag ctg acc gtc cta                330
Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                   
            100                 105                 110                   


<210>  116
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  116

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  117
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(372)
<223>  NI-307.26A3 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(339)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  117
gag gtg cag ctg gtg gag tct ggg gga gtc ttg gta cag cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Val Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

gcc atg acc tgg gtc cgc cag gct cca gag aag ggg ctg gag tgg gtc        144
Ala Met Thr Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca act att att ggt aat ggt gct tac aca tac tac gca gac tcc gtg        192
Ser Thr Ile Ile Gly Asn Gly Ala Tyr Thr Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg att        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Ile           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga gcc gac gac gcg gcc gta tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Ala Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aaa ggc aca gaa tta gcc ccc tac tac tac tac ttc gct ttg gac        336
Ala Lys Gly Thr Glu Leu Ala Pro Tyr Tyr Tyr Tyr Phe Ala Leu Asp           
            100                 105                 110                   

gtc tgg ggc caa ggg acc acg gtc acc gtc tcc tcg                        372
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser                           
        115                 120                                           


<210>  118
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  118

Glu Val Gln Leu Val Glu Ser Gly Gly Val Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ile Gly Asn Gly Ala Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Ile 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Ala Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Thr Glu Leu Ala Pro Tyr Tyr Tyr Tyr Phe Ala Leu Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  119
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  NI-307.26A3 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(105)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (268)..(294)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  119
gaa att gtg ttg acg cag tct cca ggc acc ctg tct ttg tct cca ggg         48
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly           
1               5                   10                  15                

gaa aga gcc acc ctc tcc tgc agg gcc agt cag agt att agc agc agc         96
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Ser           
            20                  25                  30                    

cac tta gcc tgg tac cag cag aaa cct ggc cag gct ccc agg ctc ctc        144
His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu           
        35                  40                  45                        

atc tat ggt gca tcc agc agg gcc act ggc atc cca gac agg ttc agt        192
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser           
    50                  55                  60                            

ggc ggt ggg tct ggg aca gac ttc act ctc acc atc acc aga ctg gag        240
Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu           
65                  70                  75                  80            

cct gaa gat ttt gca gtg tat tac tgt cag cag tat ggt agc tct ccg        288
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro           
                85                  90                  95                

tac act ttt ggc cag ggg acc aag ctg gag atc aaa                        324
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys                           
            100                 105                                       


<210>  120
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  120

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Ser 
            20                  25                  30          


His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  121
<211>  354
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(354)
<223>  NI-307.27C2 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (244)..(252)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  121
gag gtg cag ctg gtg gag tct ggg gga ggc ctg gtc aag cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttc agt agc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

acc atg aac tgg gtc cgc cag gct cca ggg aag ggg ctg cag tgg gtc        144
Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val           
        35                  40                  45                        

tca tcc atc agt agt agt agt acc tac atg tac tac gga gac tca gtg        192
Ser Ser Ile Ser Ser Ser Ser Thr Tyr Met Tyr Tyr Gly Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc aga gac aac gcc agg aac tca ctc tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga gtc gag gac acg gct gta tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga tac gcg cac gac tgg aac gtt gac tac tgg ggc cag gga acc        336
Ala Arg Tyr Ala His Asp Trp Asn Val Asp Tyr Trp Gly Gln Gly Thr           
            100                 105                 110                   

ctg gtc acc gtc tcc tcg                                                354
Leu Val Thr Val Ser Ser                                                   
        115                                                               


<210>  122
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  122

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Thr Tyr Met Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Ala His Asp Trp Asn Val Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  123
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)
<223>  NI-307.27C2 variable L-light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(105)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (268)..(300)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  123
cag tct gtg ctg act cag cca ccc tca gcg tct ggg acc ccc ggg cag         48
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln           
1               5                   10                  15                

agg gtc acc atc tct tgt tct gga ggc agc tcc aac atc gga agt aat         96
Arg Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Ser Asn           
            20                  25                  30                    

cct gtg aac tgg ttc caa caa ttc cca gga acg gcc ccc aaa ctc ctc        144
Pro Val Asn Trp Phe Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu           
        35                  40                  45                        

atc tat gct aat act cag cgg ccc tca ggg gtc cct gac cga ttc tct        192
Ile Tyr Ala Asn Thr Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser           
    50                  55                  60                            

ggc tcc aag tct ggc acc tca gtt tcc ctg gcc atc agt ggg ctc cag        240
Gly Ser Lys Ser Gly Thr Ser Val Ser Leu Ala Ile Ser Gly Leu Gln           
65                  70                  75                  80            

tct gag gat gag ggt gat tat cac tgt gca gca tgg gat gac agc ctg        288
Ser Glu Asp Glu Gly Asp Tyr His Cys Ala Ala Trp Asp Asp Ser Leu           
                85                  90                  95                

aag ggt tgg gtg ttc ggc gga ggg acc aag ctg acc gtc cta                330
Lys Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                   
            100                 105                 110                   


<210>  124
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  124

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Phe Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Asn Thr Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Val Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Gly Asp Tyr His Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Lys Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  125
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(363)
<223>  NI-307.57D4 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(330)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  125
gag gtg cag ctg gtg gag tct ggg gga ggc ctg gta cag cct ggc agg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt gat cat tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp His Tyr           
            20                  25                  30                    

gcc atg cac tgg gtc cgg caa gtt cca ggg agg ggc ctg gag tgg gtc        144
Ala Met His Trp Val Arg Gln Val Pro Gly Arg Gly Leu Glu Trp Val           
        35                  40                  45                        

tca ggt gtt act tgg aat agt ggt atc ata ggc tat gcg gac tct gtg        192
Ser Gly Val Thr Trp Asn Ser Gly Ile Ile Gly Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc aga gac aat gcc aag aat tcc ctc tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr           
65                  70                  75                  80            

ctg caa atg acc agt ctg aga gct gag gac acg gcc ttg tat tac tgt        288
Leu Gln Met Thr Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys           
                85                  90                  95                

gca aaa ggg aca aat gac ttc gta agc tac ggt ttg gac gtc tgg ggc        336
Ala Lys Gly Thr Asn Asp Phe Val Ser Tyr Gly Leu Asp Val Trp Gly           
            100                 105                 110                   

caa ggg acc acg gtc acc gtc tcc tcg                                    363
Gln Gly Thr Thr Val Thr Val Ser Ser                                       
        115                 120                                           


<210>  126
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  126

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp His Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Val Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Val Thr Trp Asn Ser Gly Ile Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Thr Asn Asp Phe Val Ser Tyr Gly Leu Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  127
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(333)
<223>  NI-307.57D4 variable L-light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(108)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(303)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  127
cag tct gtg ttg acg cag ccg ccc tca gtg tct ggg gcc cca ggg cag         48
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln           
1               5                   10                  15                

agg gtc tcc atc tcc tgc act ggg acc agc tcc aac ctc ggg gca ggt         96
Arg Val Ser Ile Ser Cys Thr Gly Thr Ser Ser Asn Leu Gly Ala Gly           
            20                  25                  30                    

ttt gat gta cac tgg tac cag cag att cca aga aaa gcc ccc gaa ctc        144
Phe Asp Val His Trp Tyr Gln Gln Ile Pro Arg Lys Ala Pro Glu Leu           
        35                  40                  45                        

ctc atc tat ggt aac agc att cgg ccc tca ggg gtc cct gac cga ttc        192
Leu Ile Tyr Gly Asn Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe           
    50                  55                  60                            

tct ggc tcc aag tct ggc acc tca gcc tcc ctg gcc atc act ggg ctc        240
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu           
65                  70                  75                  80            

cag gct gag gat gag gct gat tat tac tgc cag tcc tat gac agc agg        288
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg           
                85                  90                  95                

ttg agt ggc tcg gtg ttc ggc ggg ggg acc aag ctg acc gtc cta            333
Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu               
            100                 105                 110                   


<210>  128
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  128

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Ser Cys Thr Gly Thr Ser Ser Asn Leu Gly Ala Gly 
            20                  25                  30          


Phe Asp Val His Trp Tyr Gln Gln Ile Pro Arg Lys Ala Pro Glu Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Ile Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  129
<211>  381
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(381)
<223>  NI-307.50H4 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (151)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(348)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  129
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg ggg         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly           
1               5                   10                  15                

acc ctg tcc ctc acc tgc gct gtc tct ggt gac tcc atc agc agt agt         96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Asp Ser Ile Ser Ser Ser           
            20                  25                  30                    

aac tgg tgg agt tgg gtc cgc cag ccc cca ggg aag agg ctg gag tgg        144
Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Arg Leu Glu Trp           
        35                  40                  45                        

att ggg gag atc tat cat agt ggg ggc acc aag tac aac ccg tcc ctc        192
Ile Gly Glu Ile Tyr His Ser Gly Gly Thr Lys Tyr Asn Pro Ser Leu           
    50                  55                  60                            

aag agt cga gtc acc att tca gtg gac aag tcc aag aac cac ttc tcc        240
Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn His Phe Ser           
65                  70                  75                  80            

ctg aag ctg agg tct gtg acc gcc gcg gac acg gcc gtg tat tat tgt        288
Leu Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga aat agg tgg ttc gac aat aac cgg ggg ggc tac tac tat tac        336
Ala Arg Asn Arg Trp Phe Asp Asn Asn Arg Gly Gly Tyr Tyr Tyr Tyr           
            100                 105                 110                   

ggc atg gac gtc tgg ggc caa ggg aca atg gtc acc gtc tct tcg            381
Gly Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser               
        115                 120                 125                       


<210>  130
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  130

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Asp Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Arg Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Gly Thr Lys Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn His Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Arg Trp Phe Asp Asn Asn Arg Gly Gly Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  131
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-307.50H4 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  131
gac atc cag atg acc cag tct cca tcc tcc ctg tct gca tct gtg gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgc cgg gca ggt cag ggc att agc acc tat         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Gln Gly Ile Ser Thr Tyr           
            20                  25                  30                    

tta aat tgg tat cag cag aaa cca ggg aaa gcc cct aac ctc ctg atc        144
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile           
        35                  40                  45                        

tat gct aca tcc gat ttg caa agt ggg gtc cca tca agg ttc agt ggc        192
Tyr Ala Thr Ser Asp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggg aca gat ttc act ctc acc atc agc agt ctg caa cct        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gaa gat ttt gct act tac tac tgt caa cag agt tac aat aac ccg tac        288
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asn Asn Pro Tyr           
                85                  90                  95                

act ttt ggc cag ggg acc aag gtg gag atc aaa                            321
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys                               
            100                 105                                       


<210>  132
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  132

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Gln Gly Ile Ser Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Asp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asn Asn Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  133
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(360)
<223>  NI-307.53B11 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(327)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  133
gag gtg cag ctg gtg cag tct gga gca gag gtg aaa aag ccc ggg gaa         48
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu           
1               5                   10                  15                

tct ctg aag atc tcc tgt aag ggt tct gga tac agc ttt acc agc tac         96
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr           
            20                  25                  30                    

tgg atc ggc tgg gtg cgc cag atg ccc ggg aaa ggc ctg gag tgg atg        144
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met           
        35                  40                  45                        

ggg atc atc tat cct ggt gac tct gat acc aga tac agc ccg tcc ttc        192
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe           
    50                  55                  60                            

caa ggc cag gtc acc atc tca gcc gac aag tcc atc acc acc gcc tac        240
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Thr Thr Ala Tyr           
65                  70                  75                  80            

ctg cag tgg agc agc ctg aag gcc tcg gac acc gcc tta tat tac tgt        288
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Leu Tyr Tyr Cys           
                85                  90                  95                

gcg aga cgg ggt agt ggg agc ttc tcc aac tat gac ttc tgg ggc cag        336
Ala Arg Arg Gly Ser Gly Ser Phe Ser Asn Tyr Asp Phe Trp Gly Gln           
            100                 105                 110                   

ggc acc ctg gtc acc gtc tcc tcg                                        360
Gly Thr Leu Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  134
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  134

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Ser Gly Ser Phe Ser Asn Tyr Asp Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  135
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)
<223>  NI-307.53B11 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (67)..(108)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (271)..(300)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  135
cag tct gcc ctg act cag cct cgc tca gtg tcc ggg tct cct ggg cag         48
Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln           
1               5                   10                  15                

tca gtc acc atc tcc tgc act gga acc agc agt gat gtt ggt gct tat         96
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ala Tyr           
            20                  25                  30                    

aac tat gtc tcc tgg tac caa cag cac cca gtc aaa gcc ccc aaa ctc        144
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Val Lys Ala Pro Lys Leu           
        35                  40                  45                        

atg att tat gat gtc agt aag cgg ccc tca ggg gtc cct gat cgc ttc        192
Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe           
    50                  55                  60                            

tct ggc tcc agg tct ggc aac acg gcc tcc ctg acc atc tct ggg ctc        240
Ser Gly Ser Arg Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu           
65                  70                  75                  80            

cag gct gac gat gag gct gat tat tac tgc tgc tca tat gca ggc acc        288
Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Thr           
                85                  90                  95                

tac act gtg ctt ttc ggc gga ggg acc aag ctg acc gtc cta                330
Tyr Thr Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                   
            100                 105                 110                   


<210>  136
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  136

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ala Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Val Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Thr 
                85                  90                  95      


Tyr Thr Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  137
<211>  384
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(384)
<223>  NI-307.7J3 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(111)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (154)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(351)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  137
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tca cag         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln           
1               5                   10                  15                

acc ctg tcc ctc acc tgc act gtc tct ggt ggc tcc atc agc agt ggt         96
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly           
            20                  25                  30                    

gat tac tac tgg agt tgg atc cgc cag ccc cca ggg aag ggc ctg gag        144
Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu           
        35                  40                  45                        

tgg att ggg tac atc tat tac agt ggg acc acc tac tac aac ccg tcc        192
Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Tyr Tyr Asn Pro Ser           
    50                  55                  60                            

ctc aag agt cga gtt acc ata tca gta gac acg tcc aag aac cag ttc        240
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe           
65                  70                  75                  80            

tcc ctg aag ctg agt ttt gtg act gtc gca gac acg gcc gtg tat tac        288
Ser Leu Lys Leu Ser Phe Val Thr Val Ala Asp Thr Ala Val Tyr Tyr           
                85                  90                  95                

tgt gcc aga gat ggc cgt ttt act atg gtt cgg gga ggc tac tac tac        336
Cys Ala Arg Asp Gly Arg Phe Thr Met Val Arg Gly Gly Tyr Tyr Tyr           
            100                 105                 110                   

tac ggt atg gac gtc tgg ggc caa ggg acc acg gtc acc gtc tcc tcg        384
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser           
        115                 120                 125                       


<210>  138
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  138

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Phe Val Thr Val Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Gly Arg Phe Thr Met Val Arg Gly Gly Tyr Tyr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  139
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-307.7J3 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  139
gac atc cag atg acc cag tct cca tcc tcc ctg tct gta tct gta gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgc cgg gca agt cag agc att agc agc tat         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr           
            20                  25                  30                    

tta aat tgg tat cag cag aaa tta ggg aaa gcc cct aag ctc ctg att        144
Leu Asn Trp Tyr Gln Gln Lys Leu Gly Lys Ala Pro Lys Leu Leu Ile           
        35                  40                  45                        

tat gat gca tcc agt ttg caa agt ggg gtc cca tca agg ttc agt ggc        192
Tyr Asp Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggg aca gat ttc act ctc acc atc agc agt ctg caa cct        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gaa gat ttt gca act tac tac tgt caa cag agt tac act acc cct cga        288
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Arg           
                85                  90                  95                

acg ttc ggc caa ggg acc aag gtg gag atc aaa                            321
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys                               
            100                 105                                       


<210>  140
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  140

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Leu Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  141
<211>  369
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(369)
<223>  NI-307.59A7 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(336)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  141
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gta cag cct gga ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttc agt agt tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

gaa atg aac tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtt        144
Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca tac att agt agt agt ggt acc aac ata tac cac gca gac tct gtg        192
Ser Tyr Ile Ser Ser Ser Gly Thr Asn Ile Tyr His Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc aga gac aac gcc aag aac tca ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga gcc gag gac acg gct gtt tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gat ggt cct tca cca cgc gga cac aac tat ggt cat gac tac        336
Ala Arg Asp Gly Pro Ser Pro Arg Gly His Asn Tyr Gly His Asp Tyr           
            100                 105                 110                   

tgg ggc caa ggc acc ctg gtc acc gtc tcc tcg                            369
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                               
        115                 120                                           


<210>  142
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  142

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Thr Asn Ile Tyr His Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Pro Ser Pro Arg Gly His Asn Tyr Gly His Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  143
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)
<223>  NI-307.59A7 variable L-light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(105)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (268)..(300)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  143
cag tct gtg ctg act cag cca ccc tca gcg tct ggg acc ccc ggg cag         48
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln           
1               5                   10                  15                

agg gtc acc atc tct tgt tct gga agc agc tcc aac atc gga agt aat         96
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn           
            20                  25                  30                    

gct gta aac tgg tac cag cag gtc cca gga acg gcc ccc aaa ctc ctc        144
Ala Val Asn Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu Leu           
        35                  40                  45                        

atc tat act aat aat cag cgg ccc tca ggg gtc cct gac cga ttc tct        192
Ile Tyr Thr Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser           
    50                  55                  60                            

ggc tcc aag tct ggc acc tca gcc tcc ctg gcc atc agt ggg ctc cag        240
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln           
65                  70                  75                  80            

tct gag gat gag act gat tat tac tgt gca gca tgg gat gac agc ctg        288
Ser Glu Asp Glu Thr Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu           
                85                  90                  95                

ggt ggt ccg gtt ttc ggc gga ggg acc aag ctg acc gtc cta                330
Gly Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                   
            100                 105                 110                   


<210>  144
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  144

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Thr Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Thr Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Gly Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  145
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(363)
<223>  NI-307.105A6 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(330)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  145
gaa gtg cag ctg gtg gag tct ggg gga ggc ttg gta cag cct ggc agg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt gat gat tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr           
            20                  25                  30                    

gcc atg cac tgg gtc cgg caa gct cca ggg aag ggc ttg gag tgg gtc        144
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca ggt att act tgg aat agt ggt agt ata ggc tat gcg gac tct gtg        192
Ser Gly Ile Thr Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc aga gac aac gcc aag aac tcc cta tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agt ctg agc gct gag gac acg gcc ttg tat tac tgt        288
Leu Gln Met Asn Ser Leu Ser Ala Glu Asp Thr Ala Leu Tyr Tyr Cys           
                85                  90                  95                

gca aaa ggg gcg cgt gac tac tta agc tat ggt atg gac gtc tgg ggc        336
Ala Lys Gly Ala Arg Asp Tyr Leu Ser Tyr Gly Met Asp Val Trp Gly           
            100                 105                 110                   

caa ggg acc acg gtc acc gtc tcc tcg                                    363
Gln Gly Thr Thr Val Thr Val Ser Ser                                       
        115                 120                                           


<210>  146
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  146

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Ser Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Arg Asp Tyr Leu Ser Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  147
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(333)
<223>  NI-307.105A6 variable L-light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(108)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(303)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  147
cag tct gtc gtg acg cag ccg ccc tca gtg tct ggg gcc cca ggg cag         48
Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln           
1               5                   10                  15                

agg gtc acc atc tcc tgc act ggg agc agt tcc aac atc ggg gca ggt         96
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly           
            20                  25                  30                    

tat gat gta cac tgg tac cag cag ctt cca gga aca gcc ccc aaa ctc        144
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu           
        35                  40                  45                        

ctc atc ttt agt aac acc att cgg ccc tca ggg gtc cct gac cga ttc        192
Leu Ile Phe Ser Asn Thr Ile Arg Pro Ser Gly Val Pro Asp Arg Phe           
    50                  55                  60                            

tct ggc tcc aag tct ggc acc tca gcc tcc ctg gcc atc act ggg ctc        240
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu           
65                  70                  75                  80            

cag gct gag gat gag gct aat tat tac tgc cag tct tat gac agc agc        288
Gln Ala Glu Asp Glu Ala Asn Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser           
                85                  90                  95                

ctg agt ggt tcg gtg ttc ggc gga ggg acc aag ctg acc gtc cta            333
Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu               
            100                 105                 110                   


<210>  148
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  148

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Phe Ser Asn Thr Ile Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asn Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  149
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(372)
<223>  NI-307.29B1 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(339)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  149
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gta aag cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga atc acc ttt caa tac tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Gln Tyr Tyr           
            20                  25                  30                    

gcc atg aat tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tct tct att ggc ggt cgt ggt gat acc aca tac tac aca gac tcc gtg        192
Ser Ser Ile Gly Gly Arg Gly Asp Thr Thr Tyr Tyr Thr Asp Ser Val           
    50                  55                  60                            

aag ggc cgc ttc acc atc tcc aga gac aat tcc aag agc aca cta tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga gcc gag gac acg gcc gtc tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aaa gag cca ttt gac agt agt ggt gat cac cga ggc gtc ttt gac        336
Ala Lys Glu Pro Phe Asp Ser Ser Gly Asp His Arg Gly Val Phe Asp           
            100                 105                 110                   

tac tgg ggc cag gga acc ctg gtc acc gtc tcc tcg                        372
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                           
        115                 120                                           


<210>  150
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  150

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Gln Tyr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Gly Arg Gly Asp Thr Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Pro Phe Asp Ser Ser Gly Asp His Arg Gly Val Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  151
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)
<223>  NI-307.29B1 variable L-light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(108)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(300)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  151
cag tct gtc gtg acg cag ccg ccc tca gtg tct ggg gcc cca ggg cag         48
Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln           
1               5                   10                  15                

agg gtc acc atc tcc tgc gct ggg agc agg tcc aac atc ggg gca ggt         96
Arg Val Thr Ile Ser Cys Ala Gly Ser Arg Ser Asn Ile Gly Ala Gly           
            20                  25                  30                    

tat gat gta aat tgg tac cag caa ctt cca aga act gcc ccc aaa ctg        144
Tyr Asp Val Asn Trp Tyr Gln Gln Leu Pro Arg Thr Ala Pro Lys Leu           
        35                  40                  45                        

ctc atc tat gat aac acc agg cgg ccg tca ggt gtc cct gcc cga ttc        192
Leu Ile Tyr Asp Asn Thr Arg Arg Pro Ser Gly Val Pro Ala Arg Phe           
    50                  55                  60                            

tct ggt tcc aag tct ggc tcc tca gcc tcc ctg acc atc act ggg ctc        240
Ser Gly Ser Lys Ser Gly Ser Ser Ala Ser Leu Thr Ile Thr Gly Leu           
65                  70                  75                  80            

cag gct gaa gat gag gct gat tat tac tgc cag tcc tat gac agc aaa        288
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Lys           
                85                  90                  95                

ctg aat aaa gtg ttc ggc gga ggg acc aag ttg acc gtc cta                330
Leu Asn Lys Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                   
            100                 105                 110                   


<210>  152
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  152

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ala Gly Ser Arg Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val Asn Trp Tyr Gln Gln Leu Pro Arg Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Thr Arg Arg Pro Ser Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Ser Ser Ala Ser Leu Thr Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Lys 
                85                  90                  95      


Leu Asn Lys Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  153
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(363)
<223>  NI-307.44F6B variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(330)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  153
gag gtg cag ctg gtg gag tct ggg gga agt gtg gtt cgg cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Ser Val Val Arg Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctt gcc tgt gaa gtg tct gga ctc agg ttt gat gat ttc         96
Ser Leu Arg Leu Ala Cys Glu Val Ser Gly Leu Arg Phe Asp Asp Phe           
            20                  25                  30                    

gcc atg agt tgg gtc cgc caa gtt cca ggg aag ggg ctg gag tgg atc        144
Ala Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Ile           
        35                  40                  45                        

gct ggc att ttt tgg aac agt ggt ggc aca ctt tat gcg gat tct gtg        192
Ala Gly Ile Phe Trp Asn Ser Gly Gly Thr Leu Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc aga gac aac gcc gaa aat tcc ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Tyr           
65                  70                  75                  80            

ttg caa atg aac agt ctg aga gcc gag gac acg gcc tta tat cga tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Arg Cys           
                85                  90                  95                

gtg aga gga agg tca cac gcc gcc tac tac ggc atg gac gtc tgg ggc        336
Val Arg Gly Arg Ser His Ala Ala Tyr Tyr Gly Met Asp Val Trp Gly           
            100                 105                 110                   

aaa ggg acc acg gtc acc gtc tcc tcg                                    363
Lys Gly Thr Thr Val Thr Val Ser Ser                                       
        115                 120                                           


<210>  154
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  154

Glu Val Gln Leu Val Glu Ser Gly Gly Ser Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Glu Val Ser Gly Leu Arg Phe Asp Asp Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Gly Ile Phe Trp Asn Ser Gly Gly Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Arg Cys 
                85                  90                  95      


Val Arg Gly Arg Ser His Ala Ala Tyr Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  155
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(336)
<223>  NI-307.44F6B variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(117)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (163)..(183)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (280)..(306)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  155
gaa att gtg ctg act cag tct cca ctc tcc ctg ccc gtc acc cct gga         48
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly           
1               5                   10                  15                

gag ccg gcc tcc atc tcc tgc agg tct agt cag agc ctc ctc cac agt         96
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser           
            20                  25                  30                    

aat gga tac aac tat ttg gac tgg tac ctg cag aag cca ggg cag tct        144
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser           
        35                  40                  45                        

cca cag ctc ctg atc tat ttg ggt tct aat cgg gcc tcc ggg gtc cct        192
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro           
    50                  55                  60                            

gac agg ttc agt ggc agt gga tca ggc aca gat ttc aca ctg aca atc        240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile           
65                  70                  75                  80            

agc aga gtg gag gct gag gat gtt ggg att tat tac tgc atg caa gca        288
Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Ala           
                85                  90                  95                

cta cag aac gcg ctc gct ttc ggc gga ggg acc aag ctg gag atc aaa        336
Leu Gln Asn Ala Leu Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys           
            100                 105                 110                   


<210>  156
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  156

Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Asn Ala Leu Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  157
<211>  387
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(387)
<223>  NI-307.98H1 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(111)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (154)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(354)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  157
cag ctg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tca cag         48
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln           
1               5                   10                  15                

acc ctg tcc ctc acc tgc gct gtc tct ggt gcc tcc atc agc agt ggt         96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ala Ser Ile Ser Ser Gly           
            20                  25                  30                    

act tac tac tgg ggc tgg atc cga cag cac cca ggg aag ggc ctg gag        144
Thr Tyr Tyr Trp Gly Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu           
        35                  40                  45                        

tgg att ggg tac atc tat ccc agt ggg agc acc tac tac aac ccg tcc        192
Trp Ile Gly Tyr Ile Tyr Pro Ser Gly Ser Thr Tyr Tyr Asn Pro Ser           
    50                  55                  60                            

ctc aag agt cga gtt atc ata tca tta gac acg tct aag agc cag ttc        240
Leu Lys Ser Arg Val Ile Ile Ser Leu Asp Thr Ser Lys Ser Gln Phe           
65                  70                  75                  80            

tcc ctg aac ctg agc tct gtg act gcc gcg gac acg gcc gtg tat tac        288
Ser Leu Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr           
                85                  90                  95                

tgt gcg aga gat tac tac gat agt agt ggc cat atg ggg ggc tac tac        336
Cys Ala Arg Asp Tyr Tyr Asp Ser Ser Gly His Met Gly Gly Tyr Tyr           
            100                 105                 110                   

cac tac gct atg gac gtc tgg ggc caa ggg acc acg gtc acc gtc tcc        384
His Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser           
        115                 120                 125                       

tcg                                                                    387
Ser                                                                       
                                                                          


<210>  158
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  158

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ala Ser Ile Ser Ser Gly 
            20                  25                  30          


Thr Tyr Tyr Trp Gly Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Pro Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Ile Ile Ser Leu Asp Thr Ser Lys Ser Gln Phe 
65                  70                  75                  80  


Ser Leu Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Tyr Tyr Asp Ser Ser Gly His Met Gly Gly Tyr Tyr 
            100                 105                 110         


His Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  159
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-307.98H1 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  159
gac atc cag ttg acc cag tct cca tcc tcc ctg tct gca tct gta gga         48
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgc cgg gca agt cag agc att agt agc cat         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser His           
            20                  25                  30                    

tta aat tgg tat cag cag aaa cca ggg aaa gtc cct aag ctc ctg atc        144
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile           
        35                  40                  45                        

tat gct gca tcc acc ttg caa agt ggg gtc cca tca agg ttc agt ggc        192
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggg aca gat ttc act ctc gcc atc agc agt ctg caa cct        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ala Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gca gat ttt gca act tat tac tgt caa cag agt tac agt acc cct cgg        288
Ala Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Arg           
                85                  90                  95                

acg ttc ggc caa ggg acc aaa gtg gat atc aaa                            321
Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys                               
            100                 105                                       


<210>  160
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  160

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser His 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ala Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Ala Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  161
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(360)
<223>  NI-307.43E8 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(195)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (292)..(327)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  161
gag gtg cag ctg gtg gag tct ggg gga gac gtg gtc cag cct ggg agg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Val Val Gln Pro Gly Arg           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc gcc ttc agt att tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ile Tyr           
            20                  25                  30                    

gct atg aac tgg gtc cgc cag gct cca ggc aag ggg ctg gag tgg gtg        144
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

gca ctt ata tca act tct gga act gaa cac tac gca gac tcc gtg aag        192
Ala Leu Ile Ser Thr Ser Gly Thr Glu His Tyr Ala Asp Ser Val Lys           
    50                  55                  60                            

ggc cga ttc acc atc tcc aga gac aat tcc aag aac acg ttg ttt ctg        240
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu           
65                  70                  75                  80            

caa att aat agt ctg aga gtt gag gac acg gct gtg tat tac tgt gcg        288
Gln Ile Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys Ala           
                85                  90                  95                

aga gat ctt gac agt act ggt tat tac gag aat aac tac tgg ggc cag        336
Arg Asp Leu Asp Ser Thr Gly Tyr Tyr Glu Asn Asn Tyr Trp Gly Gln           
            100                 105                 110                   

ggc acc ctg gtc acc gtc tcc tcg                                        360
Gly Thr Leu Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  162
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  162

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ile Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Thr Ser Gly Thr Glu His Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu 
65                  70                  75                  80  


Gln Ile Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Leu Asp Ser Thr Gly Tyr Tyr Glu Asn Asn Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  163
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(336)
<223>  NI-307.43E8 complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (70)..(117)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (163)..(183)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (280)..(306)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  163
gat gtt gtg atg act cag tct cca ctc tcc tca cct gtc agt ctt gga         48
Asp Val Val Met Thr Gln Ser Pro Leu Ser Ser Pro Val Ser Leu Gly           
1               5                   10                  15                

cag ccg gcc tcc atc tcc tgc agg tct agt cac agc ctc gta cac agt         96
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser His Ser Leu Val His Ser           
            20                  25                  30                    

aat gga gat acc tac ttg agt tgg ctt cag cag agg cca ggc cag cct        144
Asn Gly Asp Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro           
        35                  40                  45                        

cca aga ctg cta atc tat aag att tct aac cga ttc tct ggg gtc cca        192
Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro           
    50                  55                  60                            

gac aga ttc agt ggc agt ggg gca ggg aca gat ttc aca ctg aaa atc        240
Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile           
65                  70                  75                  80            

agc agg gtg gaa gct gag gat gtc ggg gtc tat ttc tgc atg caa gct        288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Met Gln Ala           
                85                  90                  95                

acg tct ttt cct cga aca ttc ggc caa ggg acc aag gtg gaa atc aaa        336
Thr Ser Phe Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys           
            100                 105                 110                   


<210>  164
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  164

Asp Val Val Met Thr Gln Ser Pro Leu Ser Ser Pro Val Ser Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser His Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asp Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Met Gln Ala 
                85                  90                  95      


Thr Ser Phe Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  165
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(360)
<223>  NI-307.18F4A variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (76)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(327)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  165
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gtc aag cct gga ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttc act aac tac         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr           
            20                  25                  30                    

tac atg acc tgg gtc cgt cag gct cca gga aag ggg ctg gag tgg gtt        144
Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca tac att act ggt ggt ggg agt act aca tac tac gca gac tct gtg        192
Ser Tyr Ile Thr Gly Gly Gly Ser Thr Thr Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

acg ggc cga ttc acc atc tcc agg gac aac gcc aag aac tca ctg tat        240
Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr           
65                  70                  75                  80            

ctg caa atg agc agc ctg aga gtc gag gac acg gcc gtc tat tat tgt        288
Leu Gln Met Ser Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga ggg aga ggc tac ccc gac aac tgg ttc gac ccc tgg ggc cag        336
Ala Arg Gly Arg Gly Tyr Pro Asp Asn Trp Phe Asp Pro Trp Gly Gln           
            100                 105                 110                   

gga acc ctg gtc acc gtc tcc tcg                                        360
Gly Thr Leu Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  166
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  166

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Gly Gly Gly Ser Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Gly Tyr Pro Asp Asn Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  167
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  NI-307.18F4A variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (67)..(99)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (145)..(165)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (262)..(294)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  167
tcc tat gtg ctg act cag cca ccc tcg gtg tca gtg tcc cca gga cag         48
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln           
1               5                   10                  15                

acg gcc agg atc acc tgc tct gga gat gca ttg cca aaa caa tat gtt         96
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Val           
            20                  25                  30                    

tat tgg tac cag cag aag cca ggc cag gcc cct gtg ttg atg ata tat        144
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Met Ile Tyr           
        35                  40                  45                        

aaa gac gct gag agg ccc tca ggg atc cct gac cga ttc tct ggc tcc        192
Lys Asp Ala Glu Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser           
    50                  55                  60                            

agc tca ggg aca aca gtc act ttg acc atc agt gga gtc cag gca gaa        240
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu           
65                  70                  75                  80            

gac gag gct gac tat tac tgt cag tct aca gac atc agt ggt gct gct        288
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Thr Asp Ile Ser Gly Ala Ala           
                85                  90                  95                

gtg gtt ttc ggc gga ggg acc aag ctg acc gtc cta                        324
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                           
            100                 105                                       


<210>  168
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  168

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Val 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Met Ile Tyr 
        35                  40                  45              


Lys Asp Ala Glu Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Thr Asp Ile Ser Gly Ala Ala 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


