SEQUENCE LISTING

<110> MedImmune LLC

<120> LIQUID ANTIBODY FORMULATION WITH IMPROVED AGGREGATION PROPERTIES

<130> ANGST-300WO1

<140> Not yet assigned
<141> Not yet assigned

<150> 61/740193
<151> 2012-12-20

<160> 38

<170> 

<210> 1
<211> 366
<212> DNA
<213> Homo sapiens

<400> 1
      gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60
      tcctgtgcag tctctggatt cacctttagt agctattgga tgagctgggt ccgccaggct 120
      ccagggaagg ggctggagtg ggtggccaac ataaagcaag atggaagtga gaaatactat 180
      gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat 240
      ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatcaa 300
      ggtatagcag tggctgggcc ctttgactac tggggccagg gaaccctggt caccgtctcc 360
      tcagcc                                                            366

<210> 2
<211> 122
<212> PRT
<213> Homo sapiens

<400> 2
      Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
       1               5                  10                  15
      Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Ser Tyr
                  20                  25                  30
      Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
              35                  40                  45
      Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
          50                  55                  60
      Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
      65                  70                  75                  80
      Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                      85                  90                  95
      Ala Arg Asp Gln Gly Ile Ala Val Ala Gly Pro Phe Asp Tyr Trp Gly
                  100                 105                 110
      Gln Gly Thr Leu Val Thr Val Ser Ser Ala
              115                 120

<210> 3
<211> 322
<212> DNA
<213> Homo sapiens

<400> 3
      gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc 60
      ctctcctgca gggccagtca gactgttagc agcgacttag cctggtacca gcagaaacct 120
      ggccaggctc ccaggctcct catctatgga gcatccatta gggccactgg tatcccagcc 180
      aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240
      gaagattttg cagtttattc ctgtcagcag tattataact ggtggacgtt cggccaaggg 300
      accaaggtgg aaatcaaacg aa                                          322

<210> 4
<211> 107
<212> PRT
<213> Homo sapiens

<400> 4
      Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
       1               5                  10                  15
      Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Ser Asp
                  20                  25                  30
      Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
              35                  40                  45
      Tyr Gly Ala Ser Ile Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
          50                  55                  60
      Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
      65                  70                  75                  80
      Glu Asp Phe Ala Val Tyr Ser Cys Gln Gln Tyr Tyr Asn Trp Trp Thr
                      85                  90                  95
      Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
                  100                 105

<210> 5
<211> 366
<212> DNA
<213> Homo sapiens

<400> 5
      gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60
      tcctgtgcag tctctggatt cacctttagt agctattgga tgagctgggt ccgccaggct 120
      ccagggaagg ggctggagtg ggtggccaac ataaagcaag atggaagtga gaaatactat 180
      gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat 240
      ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatcaa 300
      ggtatagcag tggctgggcc ctttgactac tggggccagg gaaccctggt caccgtctcc 360
      tcagcc                                                            366

<210> 6
<211> 122
<212> PRT
<213> Homo sapiens

<400> 6
      Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
       1               5                  10                  15
      Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Ser Tyr
                  20                  25                  30
      Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
              35                  40                  45
      Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
          50                  55                  60
      Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
      65                  70                  75                  80
      Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                      85                  90                  95
      Ala Arg Asp Gln Gly Ile Ala Val Ala Gly Pro Phe Asp Tyr Trp Gly
                  100                 105                 110
      Gln Gly Thr Leu Val Thr Val Ser Ser Ala
              115                 120

<210> 7
<211> 322
<212> DNA
<213> Homo sapiens

<400> 7
      gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc 60
      ctctcctgca gggccagtca gactgttagc agcgacttag cctggtacca gcagaaacct 120
      ggccaggctc ccaggctcct catctatgga gcatccatta gggccactgg tatcccagcc 180
      aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240
      gaagattttg cagtttattc ctgtcagcag tattataact ggtggacgtt cggccaaggg 300
      accaaggtgg aaatcaaacg aa                                          322

<210> 8
<211> 107
<212> PRT
<213> Homo sapiens

<400> 8
      Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
       1               5                  10                  15
      Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Ser Asp
                  20                  25                  30
      Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
              35                  40                  45
      Tyr Gly Ala Ser Ile Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
          50                  55                  60
      Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
      65                  70                  75                  80
      Glu Asp Phe Ala Val Tyr Ser Cys Gln Gln Tyr Tyr Asn Trp Trp Thr
                      85                  90                  95
      Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
                  100                 105

<210> 9
<211> 366
<212> DNA
<213> Homo sapiens

<400> 9
      gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60
      tcctgtgcag tctctggatt cacctttagt agctattgga tgagctgggt ccgccaggct 120
      ccagggaagg ggctggagtg ggtggccaac ataaagcaag atggaagtga gaaatactat 180
      gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat 240
      ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatcaa 300
      ggtatagcag tggctgggcc ctttgactac tggggccagg gaaccctggt caccgtctcc 360
      tcagcc                                                            366

<210> 10
<211> 122
<212> PRT
<213> Homo sapiens

<400> 10
      Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
       1               5                  10                  15
      Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Ser Tyr
                  20                  25                  30
      Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
              35                  40                  45
      Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
          50                  55                  60
      Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
      65                  70                  75                  80
      Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                      85                  90                  95
      Ala Arg Asp Gln Gly Ile Ala Val Ala Gly Pro Phe Asp Tyr Trp Gly
                  100                 105                 110
      Gln Gly Thr Leu Val Thr Val Ser Ser Ala
              115                 120

<210> 11
<211> 322
<212> DNA
<213> Homo sapiens

<400> 11
      gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc 60
      ctctcctgca gggccagtca gactgttagc agcgacttag cctggtacca gcagaaacct 120
      ggccaggctc ccaggctcct catctatgga gcatccatta gggccactgg tatcccagcc 180
      aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240
      gaagattttg cagtttattc ctgtcagcag tattataact ggtggacgtt cggccaaggg 300
      accaaggtgg aaatcaaacg aa                                          322

<210> 12
<211> 107
<212> PRT
<213> Homo sapiens

<400> 12
      Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
       1               5                  10                  15
      Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Ser Asp
                  20                  25                  30
      Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
              35                  40                  45
      Tyr Gly Ala Ser Ile Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
          50                  55                  60
      Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
      65                  70                  75                  80
      Glu Asp Phe Ala Val Tyr Ser Cys Gln Gln Tyr Tyr Asn Trp Trp Thr
                      85                  90                  95
      Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
                  100                 105

<210> 13
<211> 372
<212> DNA
<213> Homo sapiens

<400> 13
      caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60
      tcctgtgcag cctctggatt caccttcact aactatggca tgcactgggg ccgccaggct 120
      ccaggcaagg ggctggagtg ggtggcagtt atatcacatg atggaaataa taagtattat 180
      gtagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240
      ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagaggga 300
      atcgattttt ggagtggcct caactggttc gacccctggg gccagggaac cctggtcacc 360
      gtctcctcag cc                                                     372

<210> 14
<211> 124
<212> PRT
<213> Homo sapiens

<400> 14
      Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
       1               5                  10                  15
      Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr
                  20                  25                  30
      Gly Met His Trp Gly Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
              35                  40                  45
      Ala Val Ile Ser His Asp Gly Asn Asn Lys Tyr Tyr Val Asp Ser Val
          50                  55                  60
      Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
      65                  70                  75                  80
      Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                      85                  90                  95
      Ala Arg Glu Gly Ile Asp Phe Trp Ser Gly Leu Asn Trp Phe Asp Pro
                  100                 105                 110
      Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala
              115                 120

<210> 15
<211> 327
<212> DNA
<213> Homo sapiens

<400> SEQUENCE: 15
      gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccact 60
      ctctcctgca gggccagtca gagtattacc ggcagctact tagcctggta ccagcagaaa 120
      cctggccagg ctcccagact cctcatctgt ggtgcatcca gctgggccac tggcatccca 180
      gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag tagactggag 240
      cctgaagatt ttgcagtgta ttactgtcag cagtatagta gttcaccgat caccttcggc 300
      caagggacac gactggagat taaacga                                     327

<210> 16
<211> 109
<212> PRT
<213> Homo sapiens

<400> 16
      Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
       1               5                  10                  15
      Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Thr Gly Ser
                  20                  25                  30
      Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
              35                  40                  45
      Ile Cys Gly Ala Ser Ser Trp Ala Thr Gly Ile Pro Asp Arg Phe Ser
          50                  55                  60
      Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
      65                  70                  75                  80
      Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Ser Pro
                      85                  90                  95
      Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg
                  100                 105

<210> 17
<211> 372
<212> DNA
<213> Homo sapiens

<400> 17
      caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60
      tcctgtgcag cctctggatt caccttcact aactatggca tgcactgggg ccgccaggct 120
      ccaggcaagg ggctggagtg ggtggcagtt atatcacatg atggaaataa taagtattat 180
      gtagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240
      ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagaggga 300
      atcgattttt ggagtggcct caactggttc gacccctggg gccagggaac cctggtcacc 360
      gtctcctcag cc                                                     372

<210> 18
<211> 124
<212> PRT
<213> Homo sapiens

<400> 18
      Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
       1               5                  10                  15
      Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr
                  20                  25                  30
      Gly Met His Trp Gly Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
              35                  40                  45
      Ala Val Ile Ser His Asp Gly Asn Asn Lys Tyr Tyr Val Asp Ser Val
          50                  55                  60
      Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
      65                  70                  75                  80
      Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                      85                  90                  95
      Ala Arg Glu Gly Ile Asp Phe Trp Ser Gly Leu Asn Trp Phe Asp Pro
                  100                 105                 110
      Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala
              115                 120

<210> 19
<211> 327
<212> DNA
<213> Homo sapiens

<400> 19
      gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccact 60
      ctctcctgca gggccagtca gagtattacc ggcagctact tagcctggta ccagcagaaa 120
      cctggccagg ctcccagact cctcatctgt ggtgcatcca gctgggccac tggcatccca 180
      gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag tagactggag 240
      cctgaagatt ttgcagtgta ttactgtcag cagtatagta gttcaccgat caccttcggc 300
      caagggacac gactggagat taaacga                                     327

<210> 20
<211> 109
<212> PRT
<213> Homo sapiens

<400> 20
      Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
       1               5                  10                  15
      Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Thr Gly Ser
                  20                  25                  30
      Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
              35                  40                  45
      Ile Cys Gly Ala Ser Ser Trp Ala Thr Gly Ile Pro Asp Arg Phe Ser
          50                  55                  60
      Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
      65                  70                  75                  80
      Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Ser Pro
                      85                  90                  95
      Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg
                  100                 105

<210> 21
<211> 363
<212> DNA
<213> Homo sapiens

<400> 21
      gaggtgcaga tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc 60
      tcctgtgcag cctctggatt caccttaaga agctactgga tgagctgggt ccgccaggct 120
      ccagggaagg ggctggagtg ggtggccaac ataaaggaag acggaagtga gaaataccat 180
      gtggactctg tgaagggccg attcaccatc tccagagaca acgccgagaa ctcactgttt 240
      ctgcaaatga gcagcctgcg agccgaggac acggctgtgt attactgtgc gagagatatg 300
      gaagcatcag ctggcctctt tgactactgg ggccagggaa ccctggtcac cgtctcctca 360
      gct                                                               363

<210> 22
<211> 121
<212> PRT
<213> Homo sapiens

<400> 22
      Glu Val Gln Met Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
       1               5                  10                  15
      Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Arg Ser Tyr
                  20                  25                  30
      Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
              35                  40                  45
      Ala Asn Ile Lys Glu Asp Gly Ser Glu Lys Tyr His Val Asp Ser Val
          50                  55                  60
      Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Phe
      65                  70                  75                  80
      Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                      85                  90                  95
      Ala Arg Asp Met Glu Ala Ser Ala Gly Leu Phe Asp Tyr Trp Gly Gln
                  100                 105                 110
      Gly Thr Leu Val Thr Val Ser Ser Ala
              115                 120

<210> 23
<211> 321
<212> DNA
<213> Homo sapiens

<400> 23
      gaaatagtga tgacgcagtc cccagccacc ctgtctgtgt ctccagggga aagagccatc 60
      ctctcctgca gggccagtca gagtattagc agcaacttag cctggtacca gcagaaacct 120
      ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc 180
      aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240
      gaagattttg cagtttatta ctgtcagcag tataattact ggtggacgtt cggccaaggg 300
      accaaggtgg aaatcaaacg a                                           321

<210> 24
<211> 107
<212> PRT
<213> Homo sapiens

<400> 24
      Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
       1               5                  10                  15
      Glu Arg Ala Ile Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Asn
                  20                  25                  30
      Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
              35                  40                  45
      Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
          50                  55                  60
      Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
      65                  70                  75                  80
      Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Tyr Trp Trp Thr
                      85                  90                  95
      Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
                  100                 105

<210> 25
<211> 363
<212> DNA
<213> Homo sapiens

<400> 25
      gaggtgcaga tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc 60
      tcctgtgcag cctctggatt caccttaaga agctactgga tgagctgggt ccgccaggct 120
      ccagggaagg ggctggagtg ggtggccaac ataaaggaag acggaagtga gaaataccat 180
      gtggactctg tgaagggccg attcaccatc tccagagaca acgccgagaa ctcactgttt 240
      ctgcaaatga gcagcctgcg agccgaggac acggctgtgt attactgtgc gagagatatg 300
      gaagcatcag ctggcctctt tgactactgg ggccagggaa ccctggtcac cgtctcctca 360
      gct                                                               363

<210> 26
<211> 121
<212> PRT
<213> Homo sapiens

<400> 26
      Glu Val Gln Met Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
       1               5                  10                  15
      Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Arg Ser Tyr
                  20                  25                  30
      Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
              35                  40                  45
      Ala Asn Ile Lys Glu Asp Gly Ser Glu Lys Tyr His Val Asp Ser Val
          50                  55                  60
      Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Phe
      65                  70                  75                  80
      Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                      85                  90                  95
      Ala Arg Asp Met Glu Ala Ser Ala Gly Leu Phe Asp Tyr Trp Gly Gln
                  100                 105                 110
      Gly Thr Leu Val Thr Val Ser Ser Ala
              115                 120

<210> 27
<211> 321
<212> DNA
<213> Homo sapiens

<400> 27
      gaaatagtga tgacgcagtc cccagccacc ctgtctgtgt ctccagggga aagagccatc 60
      ctctcctgca gggccagtca gagtattagc agcaacttag cctggtacca gcagaaacct 120
      ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc 180
      aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240
      gaagattttg cagtttatta ctgtcagcag tataattact ggtggacgtt cggccaaggg 300
      accaaggtgg aaatcaaacg a                                           321

<210> 28
<211> 107
<212> PRT
<213> Homo sapiens

<400> 28
      Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
       1               5                  10                  15
      Glu Arg Ala Ile Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Asn
                  20                  25                  30
      Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
              35                  40                  45
      Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
          50                  55                  60
      Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
      65                  70                  75                  80
      Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Tyr Trp Trp Thr
                      85                  90                  95
      Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
                  100                 105

<210> 29
<211> 363
<212> DNA
<213> Homo sapiens

<400> 29
      gaggtgcaga tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc 60
      tcctgtgcag cctctggatt caccttaaga agctactgga tgagctgggt ccgccaggct 120
      ccagggaagg ggctggagtg ggtggccaac ataaaggaag acggaagtga gaaataccat 180
      gtggactctg tgaagggccg attcaccatc tccagagaca acgccgagaa ctcactgttt 240
      ctgcaaatga gcagcctgcg agccgaggac acggctgtgt attactgtgc gagagatatg 300
      gaagcatcag ctggcctctt tgactactgg ggccagggaa ccctggtcac cgtctcctca 360
      gct                                                               363

<210> 30
<211> 121
<212> PRT
<213> Homo sapiens

<400> 30
      Glu Val Gln Met Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
       1               5                  10                  15
      Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Arg Ser Tyr
                  20                  25                  30
      Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
              35                  40                  45
      Ala Asn Ile Lys Glu Asp Gly Ser Glu Lys Tyr His Val Asp Ser Val
          50                  55                  60
      Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Phe
      65                  70                  75                  80
      Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                      85                  90                  95
      Ala Arg Asp Met Glu Ala Ser Ala Gly Leu Phe Asp Tyr Trp Gly Gln
                  100                 105                 110
      Gly Thr Leu Val Thr Val Ser Ser Ala
              115                 120

<210> 31
<211> 321
<212> DNA
<213> Homo sapiens

<400> 31
      gaaatagtga tgacgcagtc cccagccacc ctgtctgtgt ctccagggga aagagccatc 60
      ctctcctgca gggccagtca gagtattagc agcaacttag cctggtacca gcagaaacct 120
      ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc 180
      aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240
      gaagattttg cagtttatta ctgtcagcag tataattact ggtggacgtt cggccaaggg 300
      accaaggtgg aaatcaaacg a                                           321

<210> 32
<211> 107
<212> PRT
<213> Homo sapiens

<400> 32
      Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
       1               5                  10                  15
      Glu Arg Ala Ile Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Asn
                  20                  25                  30
      Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
              35                  40                  45
      Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
          50                  55                  60
      Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
      65                  70                  75                  80
      Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Tyr Trp Trp Thr
                      85                  90                  95
      Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
                  100                 105

<210> 33
<211> 215
<212> PRT
<213> Artificial

<220>
<223> Synthetic construct

<400> 33
      Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
      1               5                   10                  15
      Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Thr Gly Ser
                  20                  25                  30
      Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
              35                  40                  45
      Ile Thr Gly Ala Ser Ser Trp Ala Thr Gly Ile Pro Asp Arg Phe Ser
          50                  55                  60
      Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
      65                  70                  75                  80
      Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Ser Pro
                      85                  90                  95
      Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala
                  100                 105                 110 
      Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
              115                 120                 125
      Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
          130                 135                     140
      Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
      145                 150                 155                 160
      Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                      165                 170                 175
      Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                  180                 185                 190 
      Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
              195                 200                 205
      Ser Phe Asn Arg Gly Glu Cys
          210                 215

<210> 34
<211> 215
<212> PRT
<213> Artificial

<220>
<223> Synthetic construct

<400> 34
      Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
      1               5                   10                  15
      Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Thr Gly Ser
                  20                  25                  30
      Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
              35                  40                  45
      Ile Asn Gly Ala Ser Ser Trp Ala Thr Gly Ile Pro Asp Arg Phe Ser
          50                  55                  60
      Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
      65                  70                  75                  80
      Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Ser Pro
                      85                  90                  95
      Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala
                  100                 105                 110
      Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
              115                 120                 125
      Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
          130                 135                 140
      Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
      145                 150                 155                 160
      Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                      165                 170                 175
      Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                  180                 185                 190
      Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
              195                 200                 205
      Ser Phe Asn Arg Gly Glu Cys
          210                 215

<210> 35
<211> 215
<212> PRT
<213> Artificial

<220>
<223> Synthetic construct

<400> 35
      Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
      1               5                   10                  15
      Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Thr Gly Ser
                  20                  25                  30
      Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
              35                  40                  45
      Ile Asp Gly Ala Ser Ser Trp Ala Thr Gly Ile Pro Asp Arg Phe Ser
          50                  55                  60
      Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
      65                  70                  75                  80
      Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Ser Pro
                      85                  90                  95
      Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala
                  100                 105                 110
      Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
              115                 120                 125
      Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
          130                 135                 140
      Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
      145                 150                 155                 160
      Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                      165                 170                 175
      Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                  180                 185                 190
      Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
              195                 200                 205
      Ser Phe Asn Arg Gly Glu Cys
          210                 215

<210> 36
<211> 215
<212> PRT
<213> Artificial

<220>
<223> Synthetic construct

<400> 36
      Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
      1               5                   10                  15
      Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Thr Gly Ser
                  20                  25                  30
      Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
              35                  40                  45
      Ile Ala Gly Ala Ser Ser Trp Ala Thr Gly Ile Pro Asp Arg Phe Ser
          50                  55                  60
      Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
      65                  70                  75                  80
      Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Ser Pro
                      85                  90                  95
      Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala
                  100                 105                 110
      Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
              115                 120                 125
      Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
          130                 135                 140
      Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
      145                 150                 155                 160
      Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                      165                 170                 175
      Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                  180                 185                 190	
      Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
              195                 200                 205
      Ser Phe Asn Arg Gly Glu Cys
          210                 215

<210> 37
<211> 123
<212> PRT
<213> Artificial

<220>
<223> Synthetic construct

<400> 37
      Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
      1               5                   10                  15
      Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr
                  20                  25                  30
      Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
              35                  40                  45
      Ala Val Ile Ser His Asp Gly Asn Asn Lys Tyr Tyr Val Asp Ser Val
          50                  55                  60
      Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
      65                  70                  75                  80
      Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                      85                  90                  95
      Ala Arg Glu Gly Ile Asp Phe Trp Ser Gly Leu Asn Trp Phe Asp Pro    
                  100                 105                 110
      Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
              115                 120

<210> 38
<211> 215
<212> PRT
<213> Artificial

<220>
<223> Synthetic construct

<400> 38
      Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
      1               5                   10                  15
      Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Thr Gly Ser
                  20                  25                  30
      Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
              35                  40                  45
      Ile Thr Gly Ala Ser Ser Trp Ala Thr Gly Ile Ala Asp Arg Phe Ser
          50                  55                  60
      Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
      65                  70                  75                  80
      Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Ser Pro
                      85                  90                  95
      Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala
                  100                 105                 110
      Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
              115                 120                 125
      Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
          130                 135                 140
      Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
      145                 150                 155                 160
      Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                      165                 170                 175
      Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                  180                 185                 190
      Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
              195                 200                 205
      Ser Phe Asn Arg Gly Glu Cys
          210                 215

