                         SEQUENCE LISTING

<110>  bluebird bio, Inc.
       Finer, Mitchell Howard

 
<120>  CHIMERIC ANTIGEN RECEPTORS AND IMMUNE CELLS TARGETING B CELL 
       MALIGNANCIES

<130>  BLBD-023/02WO

<150>  US 61/780,687
<151>  2013-03-13

<150>  US 61/740,120
<151>  2012-12-20

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  8171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding the CD37-BZ chimeric antigen 
       receptor

<400>  1
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt gcggccgctg gaagggctaa      420

tttggtccca aaaaagacaa gagatccttg atctgtggat ctaccacaca caaggctact      480

tccctgattg gcagaactac acaccagggc cagggatcag atatccactg acctttggat      540

ggtgcttcaa gttagtacca gttgaaccag agcaagtaga agaggccaat gaaggagaga      600

acaacagctt gttacaccct atgagccagc atgggatgga ggacccggag ggagaagtat      660

tagtgtggaa gtttgacagc ctcctagcat ttcgtcacat ggcccgagag ctgcatccgg      720

agtactacaa agactgctga catcgagctt tctacaaggg actttccgct ggggactttc      780

cagggaggtg tggcctgggc gggactgggg agtggcgagc cctcagatgc tacatataag      840

cagctgcttt ttgcctgtac tgggtctctc tggttagacc agatctgagc ctgggagctc      900

tctggctaac tagggaaccc actgcttaag cctcaataaa gcttgccttg agtgctcaaa      960

gtagtgtgtg cccgtctgtt gtgtgactct ggtaactaga gatccctcag acccttttag     1020

tcagtgtgga aaatctctag cagtggcgcc cgaacaggga cttgaaagcg aaagtaaagc     1080

cagaggagat ctctcgacgc aggactcggc ttgctgaagc gcgcacggca agaggcgagg     1140

ggcggcgact ggtgagtacg ccaaaaattt tgactagcgg aggctagaag gagagagtag     1200

ggtgcgagag cgtcggtatt aagcggggga gaattagata aatgggaaaa aattcggtta     1260

aggccagggg gaaagaaaca atataaacta aaacatatag ttagggcaag cagggagcta     1320

gaacgattcg cagttaatcc tggcctttta gagacatcag aaggctgtag acaaatactg     1380

ggacagctac aaccatccct tcagacagga tcagaagaac ttagatcatt atataataca     1440

atagcagtcc tctattgtgt gcatcaaagg atagatgtaa aagacaccaa ggaagcctta     1500

gataagatag aggaagagca aaacaaaagt aagaaaaagg cacagcaagc agcagctgac     1560

acaggaaaca acagccaggt cagccaaaat taccctatag tgcagaacct ccaggggcaa     1620

atggtacatc aggccatatc acctagaact ttaaattaag acagcagtac aaatggcagt     1680

attcatccac aattttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat     1740

agtagacata atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat     1800

tcaaaatttt cgggtttatt acagggacag cagagatcca gtttggaaag gaccagcaaa     1860

gctcctctgg aaaggtgaag gggcagtagt aatacaagat aatagtgaca taaaagtagt     1920

gccaagaaga aaagcaaaga tcatcaggga ttatggaaaa cagatggcag gtgatgattg     1980

tgtggcaagt agacaggatg aggattaaca catggaaaag attagtaaaa caccatagct     2040

ctagagcgat cccgatcttc agacctggag gaggagatat gagggacaat tggagaagtg     2100

aattatataa atataaagta gtaaaaattg aaccattagg agtagcaccc accaaggcaa     2160

agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg ttccttgggt     2220

tcttgggagc agcaggaagc actatgggcg cagcgtcaat gacgctgacg gtacaggcca     2280

gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct attgaggcgc     2340

aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca agaatcctgg     2400

ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc tctggaaaac     2460

tcatttgcac cactgctgtg ccttggaatg ctagttggag taataaatct ctggaacaga     2520

tttggaatca cacgacctgg atggagtggg acagagaaat taacaattac acaagcttgg     2580

taggtttaag aatagttttt gctgtacttt ctatagtgaa tagagttagg cagggatatt     2640

caccattatc gtttcagacc cacctcccaa ccccgagggg acccgacagg cccgaaggaa     2700

tagaagaaga aggtggagag agagacagag acagatccat tcgattagtg aacggatcca     2760

tcgtcgagag gctccggtgc ccgtcagtgg gcagagcgca catcgcccac agtccccgag     2820

aagttggggg gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg cggggtaaac     2880

tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg agggtggggg agaaccgtat     2940

ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc cagaacacag     3000

gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg     3060

ccttgaatta cttccacgcc cctggctgca gtacgtgatt cttgatcccg agcttcgggt     3120

tggaagtggg tgggagagtt cgaggccttg cgcttaagga gccccttcgc ctcgtgcttg     3180

agttgaggcc tggcctgggc gctggggccg ccgcgtgcga atctggtggc accttcgcgc     3240

ctgtctcgct gctttcgata agtctctagc catttaaaat ttttgatgac ctgctgcgac     3300

gctttttttc tggcaagata gtcttgtaaa tgcgggccaa gatctgcaca ctggtatttc     3360

ggtttttggg gccgcgggcg gcgacggggc ccgtgcgtcc cagcgcacat gttcggcgag     3420

gcggggcctg cgagcgcggc caccgagaat cggacggggg tagtctcaag ctggccggcc     3480

tgctctggtg cctggcctcg cgccgccgtg tatcgccccg ccctgggcgg caaggctggc     3540

ccggtcggca ccagttgcgt gagcggaaag atggccgctt cccggccctg ctgcagggag     3600

ctcaaaatgg aggacgcggc gctcgggaga gcgggcgggt gagtcaccca cacaaaggaa     3660

aagggccttt ccgtcctcag ccgtcgcttc atgtgactcc acggagtacc gggcgccgtc     3720

caggcacctc gattagttct cgagcttttg gagtacgtcg tctttaggtt ggggggaggg     3780

gttttatgcg atggagtttc cccacactga gtgggtggag actgaagtta ggccagcttg     3840

gcacttgatg taattctcct tggaatttgc cctttttgag tttggatctt ggttcattct     3900

caagcctcag acagtggttc aaagtttttt tcttccattt caggtgtcgt gagaattagc     3960

acgcgtccgc caccatggcc ttaccagtga ccgccttgct cctgccgctg gccttgctgc     4020

tccacgccgc caggccggac atccagatga ctcagtctcc agcctcccta tctgcatctg     4080

tgggagagac tgtcaccatc acatgtcgaa caagtgaaaa tgtttacagt tatttggctt     4140

ggtatcagca gaaacaggga aaatctcctc agctcctggt ctcttttgca aaaaccttag     4200

cagaaggtgt gccatcaagg ttcagtggca gtggatcagg cacacagttt tctctgaaga     4260

tcagcagcct gcagcctgaa gattctggaa gttatttctg tcaacatcat tccgataatc     4320

cgtggacgtt cggtggaggc accgaactgg agatcaaagg tggcggtggc tcgggcggtg     4380

gtgggtcggg tggcggcgga tcgtcagcgg tccagctgca gcagtctgga cctgagtcgg     4440

aaaagcctgg cgcttcagtg aagatttcct gcaaggcttc tggttactca ttcactggct     4500

acaatatgaa ctgggtgaag cagaataatg gaaagagcct tgagtggatt ggaaatattg     4560

atccttatta tggtggtact acctacaacc ggaagttcaa gggcaaggcc acattgactg     4620

tagacaaatc ctccagcaca gcctacatgc agctcaagag tctgacatct gaggactctg     4680

cagtctatta ctgtgcaaga tcggtcggcc ctatggacta ctggggtcaa ggaacctcag     4740

tcaccgtctc ttctaccacg acgccagcgc cgcgaccacc aacaccggcg cccaccatcg     4800

cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc     4860

acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg gccgggactt     4920

gtggggtcct tctcctgtca ctggttatca ccctttacaa acggggcaga aagaaactcc     4980

tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag gaagatggct     5040

gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg aagttcagca     5100

ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac gagctcaatc     5160

taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac cctgagatgg     5220

ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg cagaaagata     5280

agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg ggcaaggggc     5340

acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac gcccttcaca     5400

tgcaggccct gccccctcgc taatgagtcg acggtacctt taagaccaat gacttacaag     5460

gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg gctaattcac     5520

tcccaaagaa gacaagatct gctttttgcc tgtactgggt ctctctggtt agaccagatc     5580

tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg     5640

ccttgagtgc ttcaatgtgt gtgttggttt tttgtgtgtc gaaattctag cgattctagc     5700

ttggcgtaat catggtcata gctgtttcct gtgtgaaatt gttatccgct cacaattcca     5760

cacaacatac gagccggaag cataaagtgt aaagcctggg gtgcctaatg agtgagctaa     5820

ctcacattaa ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag     5880

ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc     5940

gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct     6000

cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg     6060

tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc     6120

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga     6180

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct     6240

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg     6300

gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag     6360

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat     6420

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac     6480

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac     6540

tacggctaca ctagaagaac agtatttggt atctgcgctc tgctgaagcc agttaccttc     6600

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt     6660

tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc     6720

ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg     6780

agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca     6840

atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca     6900

cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag     6960

ataactacga tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagac     7020

ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc     7080

agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct     7140

agagtaagta gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc     7200

gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg     7260

cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc     7320

gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat     7380

tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag     7440

tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat     7500

aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg     7560

cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca     7620

cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga     7680

aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc     7740

ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag cggatacata     7800

tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg     7860

ccacctggga ctagcttttt gcaaaagcct aggcctccaa aaaagcctcc tcactacttc     7920

tggaatagct cagaggccga ggcggcctcg gcctctgcat aaataaaaaa aattagtcag     7980

ccatggggcg gagaatgggc ggaactgggc ggagttaggg gcgggatggg cggagttagg     8040

ggcgggacta tggttgctga ctaattgaga tgagcttgca tgccgacatt gattattgac     8100

tagtccctaa gaaaccattc ttatcatgac attaacctat aaaaataggc gtatcacgag     8160

gccctttcgt c                                                          8171


<210>  2
<211>  8168
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding the CD37-28Z chimeric antigen 
       receptor

<400>  2
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt gcggccgctg gaagggctaa      420

tttggtccca aaaaagacaa gagatccttg atctgtggat ctaccacaca caaggctact      480

tccctgattg gcagaactac acaccagggc cagggatcag atatccactg acctttggat      540

ggtgcttcaa gttagtacca gttgaaccag agcaagtaga agaggccaat gaaggagaga      600

acaacagctt gttacaccct atgagccagc atgggatgga ggacccggag ggagaagtat      660

tagtgtggaa gtttgacagc ctcctagcat ttcgtcacat ggcccgagag ctgcatccgg      720

agtactacaa agactgctga catcgagctt tctacaaggg actttccgct ggggactttc      780

cagggaggtg tggcctgggc gggactgggg agtggcgagc cctcagatgc tacatataag      840

cagctgcttt ttgcctgtac tgggtctctc tggttagacc agatctgagc ctgggagctc      900

tctggctaac tagggaaccc actgcttaag cctcaataaa gcttgccttg agtgctcaaa      960

gtagtgtgtg cccgtctgtt gtgtgactct ggtaactaga gatccctcag acccttttag     1020

tcagtgtgga aaatctctag cagtggcgcc cgaacaggga cttgaaagcg aaagtaaagc     1080

cagaggagat ctctcgacgc aggactcggc ttgctgaagc gcgcacggca agaggcgagg     1140

ggcggcgact ggtgagtacg ccaaaaattt tgactagcgg aggctagaag gagagagtag     1200

ggtgcgagag cgtcggtatt aagcggggga gaattagata aatgggaaaa aattcggtta     1260

aggccagggg gaaagaaaca atataaacta aaacatatag ttagggcaag cagggagcta     1320

gaacgattcg cagttaatcc tggcctttta gagacatcag aaggctgtag acaaatactg     1380

ggacagctac aaccatccct tcagacagga tcagaagaac ttagatcatt atataataca     1440

atagcagtcc tctattgtgt gcatcaaagg atagatgtaa aagacaccaa ggaagcctta     1500

gataagatag aggaagagca aaacaaaagt aagaaaaagg cacagcaagc agcagctgac     1560

acaggaaaca acagccaggt cagccaaaat taccctatag tgcagaacct ccaggggcaa     1620

atggtacatc aggccatatc acctagaact ttaaattaag acagcagtac aaatggcagt     1680

attcatccac aattttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat     1740

agtagacata atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat     1800

tcaaaatttt cgggtttatt acagggacag cagagatcca gtttggaaag gaccagcaaa     1860

gctcctctgg aaaggtgaag gggcagtagt aatacaagat aatagtgaca taaaagtagt     1920

gccaagaaga aaagcaaaga tcatcaggga ttatggaaaa cagatggcag gtgatgattg     1980

tgtggcaagt agacaggatg aggattaaca catggaaaag attagtaaaa caccatagct     2040

ctagagcgat cccgatcttc agacctggag gaggagatat gagggacaat tggagaagtg     2100

aattatataa atataaagta gtaaaaattg aaccattagg agtagcaccc accaaggcaa     2160

agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg ttccttgggt     2220

tcttgggagc agcaggaagc actatgggcg cagcgtcaat gacgctgacg gtacaggcca     2280

gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct attgaggcgc     2340

aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca agaatcctgg     2400

ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc tctggaaaac     2460

tcatttgcac cactgctgtg ccttggaatg ctagttggag taataaatct ctggaacaga     2520

tttggaatca cacgacctgg atggagtggg acagagaaat taacaattac acaagcttgg     2580

taggtttaag aatagttttt gctgtacttt ctatagtgaa tagagttagg cagggatatt     2640

caccattatc gtttcagacc cacctcccaa ccccgagggg acccgacagg cccgaaggaa     2700

tagaagaaga aggtggagag agagacagag acagatccat tcgattagtg aacggatcca     2760

tcgtcgagag gctccggtgc ccgtcagtgg gcagagcgca catcgcccac agtccccgag     2820

aagttggggg gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg cggggtaaac     2880

tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg agggtggggg agaaccgtat     2940

ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc cagaacacag     3000

gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg     3060

ccttgaatta cttccacgcc cctggctgca gtacgtgatt cttgatcccg agcttcgggt     3120

tggaagtggg tgggagagtt cgaggccttg cgcttaagga gccccttcgc ctcgtgcttg     3180

agttgaggcc tggcctgggc gctggggccg ccgcgtgcga atctggtggc accttcgcgc     3240

ctgtctcgct gctttcgata agtctctagc catttaaaat ttttgatgac ctgctgcgac     3300

gctttttttc tggcaagata gtcttgtaaa tgcgggccaa gatctgcaca ctggtatttc     3360

ggtttttggg gccgcgggcg gcgacggggc ccgtgcgtcc cagcgcacat gttcggcgag     3420

gcggggcctg cgagcgcggc caccgagaat cggacggggg tagtctcaag ctggccggcc     3480

tgctctggtg cctggcctcg cgccgccgtg tatcgccccg ccctgggcgg caaggctggc     3540

ccggtcggca ccagttgcgt gagcggaaag atggccgctt cccggccctg ctgcagggag     3600

ctcaaaatgg aggacgcggc gctcgggaga gcgggcgggt gagtcaccca cacaaaggaa     3660

aagggccttt ccgtcctcag ccgtcgcttc atgtgactcc acggagtacc gggcgccgtc     3720

caggcacctc gattagttct cgagcttttg gagtacgtcg tctttaggtt ggggggaggg     3780

gttttatgcg atggagtttc cccacactga gtgggtggag actgaagtta ggccagcttg     3840

gcacttgatg taattctcct tggaatttgc cctttttgag tttggatctt ggttcattct     3900

caagcctcag acagtggttc aaagtttttt tcttccattt caggtgtcgt gagaattagc     3960

acgcgtccgc caccatggcc ttaccagtga ccgccttgct cctgccgctg gccttgctgc     4020

tccacgccgc caggccggac atccagatga ctcagtctcc agcctcccta tctgcatctg     4080

tgggagagac tgtcaccatc acatgtcgaa caagtgaaaa tgtttacagt tatttggctt     4140

ggtatcagca gaaacaggga aaatctcctc agctcctggt ctcttttgca aaaaccttag     4200

cagaaggtgt gccatcaagg ttcagtggca gtggatcagg cacacagttt tctctgaaga     4260

tcagcagcct gcagcctgaa gattctggaa gttatttctg tcaacatcat tccgataatc     4320

cgtggacgtt cggtggaggc accgaactgg agatcaaagg tggcggtggc tcgggcggtg     4380

gtgggtcggg tggcggcgga tcgtcagcgg tccagctgca gcagtctgga cctgagtcgg     4440

aaaagcctgg cgcttcagtg aagatttcct gcaaggcttc tggttactca ttcactggct     4500

acaatatgaa ctgggtgaag cagaataatg gaaagagcct tgagtggatt ggaaatattg     4560

atccttatta tggtggtact acctacaacc ggaagttcaa gggcaaggcc acattgactg     4620

tagacaaatc ctccagcaca gcctacatgc agctcaagag tctgacatct gaggactctg     4680

cagtctatta ctgtgcaaga tcggtcggcc ctatggacta ctggggtcaa ggaacctcag     4740

tcaccgtctc ttctaccacg acgccagcgc cgcgaccacc aacaccggcg cccaccatcg     4800

cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc     4860

acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg gccgggactt     4920

gtggggtcct tctcctgtca ctggttatca ccctttacag gagtaagagg agcaggctcc     4980

tgcacagtga ctacatgaac atgactcccc gccgccccgg gcccacccgc aagcattacc     5040

agccctatgc cccaccacgc gacttcgcag cctatcgctc cagagtgaag ttcagcagga     5100

gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag ctcaatctag     5160

gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct gagatggggg     5220

gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag aaagataaga     5280

tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc aaggggcacg     5340

atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc cttcacatgc     5400

aggccctgcc ccctcgctaa tgagtcgacg gtacctttaa gaccaatgac ttacaaggca     5460

gctgtagatc ttagccactt tttaaaagaa aaggggggac tggaagggct aattcactcc     5520

caaagaagac aagatctgct ttttgcctgt actgggtctc tctggttaga ccagatctga     5580

gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct     5640

tgagtgcttc aatgtgtgtg ttggtttttt gtgtgtcgaa attctagcga ttctagcttg     5700

gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac     5760

aacatacgag ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt gagctaactc     5820

acattaattg cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc gtgccagctg     5880

cattaatgaa tcggccaacg cgcggggaga ggcggtttgc gtattgggcg ctcttccgct     5940

tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac     6000

tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga     6060

gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat     6120

aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac     6180

ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct     6240

gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg     6300

ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg     6360

ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt     6420

cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg     6480

attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac     6540

ggctacacta gaagaacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga     6600

aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt     6660

gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt     6720

tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga     6780

ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc     6840

taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct     6900

atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata     6960

actacgatac gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca     7020

cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga     7080

agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga     7140

gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg     7200

gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga     7260

gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt     7320

gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct     7380

cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca     7440

ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat     7500

accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga     7560

aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc     7620

aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg     7680

caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc     7740

ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt     7800

gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca     7860

cctgggacta gctttttgca aaagcctagg cctccaaaaa agcctcctca ctacttctgg     7920

aatagctcag aggccgaggc ggcctcggcc tctgcataaa taaaaaaaat tagtcagcca     7980

tggggcggag aatgggcgga actgggcgga gttaggggcg ggatgggcgg agttaggggc     8040

gggactatgg ttgctgacta attgagatga gcttgcatgc cgacattgat tattgactag     8100

tccctaagaa accattctta tcatgacatt aacctataaa aataggcgta tcacgaggcc     8160

ctttcgtc                                                              8168


<210>  3
<211>  8294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding the CD37-28BZ chimeric antigen 
       receptor

<400>  3
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt gcggccgctg gaagggctaa      420

tttggtccca aaaaagacaa gagatccttg atctgtggat ctaccacaca caaggctact      480

tccctgattg gcagaactac acaccagggc cagggatcag atatccactg acctttggat      540

ggtgcttcaa gttagtacca gttgaaccag agcaagtaga agaggccaat gaaggagaga      600

acaacagctt gttacaccct atgagccagc atgggatgga ggacccggag ggagaagtat      660

tagtgtggaa gtttgacagc ctcctagcat ttcgtcacat ggcccgagag ctgcatccgg      720

agtactacaa agactgctga catcgagctt tctacaaggg actttccgct ggggactttc      780

cagggaggtg tggcctgggc gggactgggg agtggcgagc cctcagatgc tacatataag      840

cagctgcttt ttgcctgtac tgggtctctc tggttagacc agatctgagc ctgggagctc      900

tctggctaac tagggaaccc actgcttaag cctcaataaa gcttgccttg agtgctcaaa      960

gtagtgtgtg cccgtctgtt gtgtgactct ggtaactaga gatccctcag acccttttag     1020

tcagtgtgga aaatctctag cagtggcgcc cgaacaggga cttgaaagcg aaagtaaagc     1080

cagaggagat ctctcgacgc aggactcggc ttgctgaagc gcgcacggca agaggcgagg     1140

ggcggcgact ggtgagtacg ccaaaaattt tgactagcgg aggctagaag gagagagtag     1200

ggtgcgagag cgtcggtatt aagcggggga gaattagata aatgggaaaa aattcggtta     1260

aggccagggg gaaagaaaca atataaacta aaacatatag ttagggcaag cagggagcta     1320

gaacgattcg cagttaatcc tggcctttta gagacatcag aaggctgtag acaaatactg     1380

ggacagctac aaccatccct tcagacagga tcagaagaac ttagatcatt atataataca     1440

atagcagtcc tctattgtgt gcatcaaagg atagatgtaa aagacaccaa ggaagcctta     1500

gataagatag aggaagagca aaacaaaagt aagaaaaagg cacagcaagc agcagctgac     1560

acaggaaaca acagccaggt cagccaaaat taccctatag tgcagaacct ccaggggcaa     1620

atggtacatc aggccatatc acctagaact ttaaattaag acagcagtac aaatggcagt     1680

attcatccac aattttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat     1740

agtagacata atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat     1800

tcaaaatttt cgggtttatt acagggacag cagagatcca gtttggaaag gaccagcaaa     1860

gctcctctgg aaaggtgaag gggcagtagt aatacaagat aatagtgaca taaaagtagt     1920

gccaagaaga aaagcaaaga tcatcaggga ttatggaaaa cagatggcag gtgatgattg     1980

tgtggcaagt agacaggatg aggattaaca catggaaaag attagtaaaa caccatagct     2040

ctagagcgat cccgatcttc agacctggag gaggagatat gagggacaat tggagaagtg     2100

aattatataa atataaagta gtaaaaattg aaccattagg agtagcaccc accaaggcaa     2160

agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg ttccttgggt     2220

tcttgggagc agcaggaagc actatgggcg cagcgtcaat gacgctgacg gtacaggcca     2280

gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct attgaggcgc     2340

aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca agaatcctgg     2400

ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc tctggaaaac     2460

tcatttgcac cactgctgtg ccttggaatg ctagttggag taataaatct ctggaacaga     2520

tttggaatca cacgacctgg atggagtggg acagagaaat taacaattac acaagcttgg     2580

taggtttaag aatagttttt gctgtacttt ctatagtgaa tagagttagg cagggatatt     2640

caccattatc gtttcagacc cacctcccaa ccccgagggg acccgacagg cccgaaggaa     2700

tagaagaaga aggtggagag agagacagag acagatccat tcgattagtg aacggatcca     2760

tcgtcgagag gctccggtgc ccgtcagtgg gcagagcgca catcgcccac agtccccgag     2820

aagttggggg gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg cggggtaaac     2880

tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg agggtggggg agaaccgtat     2940

ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc cagaacacag     3000

gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg     3060

ccttgaatta cttccacgcc cctggctgca gtacgtgatt cttgatcccg agcttcgggt     3120

tggaagtggg tgggagagtt cgaggccttg cgcttaagga gccccttcgc ctcgtgcttg     3180

agttgaggcc tggcctgggc gctggggccg ccgcgtgcga atctggtggc accttcgcgc     3240

ctgtctcgct gctttcgata agtctctagc catttaaaat ttttgatgac ctgctgcgac     3300

gctttttttc tggcaagata gtcttgtaaa tgcgggccaa gatctgcaca ctggtatttc     3360

ggtttttggg gccgcgggcg gcgacggggc ccgtgcgtcc cagcgcacat gttcggcgag     3420

gcggggcctg cgagcgcggc caccgagaat cggacggggg tagtctcaag ctggccggcc     3480

tgctctggtg cctggcctcg cgccgccgtg tatcgccccg ccctgggcgg caaggctggc     3540

ccggtcggca ccagttgcgt gagcggaaag atggccgctt cccggccctg ctgcagggag     3600

ctcaaaatgg aggacgcggc gctcgggaga gcgggcgggt gagtcaccca cacaaaggaa     3660

aagggccttt ccgtcctcag ccgtcgcttc atgtgactcc acggagtacc gggcgccgtc     3720

caggcacctc gattagttct cgagcttttg gagtacgtcg tctttaggtt ggggggaggg     3780

gttttatgcg atggagtttc cccacactga gtgggtggag actgaagtta ggccagcttg     3840

gcacttgatg taattctcct tggaatttgc cctttttgag tttggatctt ggttcattct     3900

caagcctcag acagtggttc aaagtttttt tcttccattt caggtgtcgt gagaattagc     3960

acgcgtccgc caccatggcc ttaccagtga ccgccttgct cctgccgctg gccttgctgc     4020

tccacgccgc caggccggac atccagatga ctcagtctcc agcctcccta tctgcatctg     4080

tgggagagac tgtcaccatc acatgtcgaa caagtgaaaa tgtttacagt tatttggctt     4140

ggtatcagca gaaacaggga aaatctcctc agctcctggt ctcttttgca aaaaccttag     4200

cagaaggtgt gccatcaagg ttcagtggca gtggatcagg cacacagttt tctctgaaga     4260

tcagcagcct gcagcctgaa gattctggaa gttatttctg tcaacatcat tccgataatc     4320

cgtggacgtt cggtggaggc accgaactgg agatcaaagg tggcggtggc tcgggcggtg     4380

gtgggtcggg tggcggcgga tcgtcagcgg tccagctgca gcagtctgga cctgagtcgg     4440

aaaagcctgg cgcttcagtg aagatttcct gcaaggcttc tggttactca ttcactggct     4500

acaatatgaa ctgggtgaag cagaataatg gaaagagcct tgagtggatt ggaaatattg     4560

atccttatta tggtggtact acctacaacc ggaagttcaa gggcaaggcc acattgactg     4620

tagacaaatc ctccagcaca gcctacatgc agctcaagag tctgacatct gaggactctg     4680

cagtctatta ctgtgcaaga tcggtcggcc ctatggacta ctggggtcaa ggaacctcag     4740

tcaccgtctc ttctaccacg acgccagcgc cgcgaccacc aacaccggcg cccaccatcg     4800

cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc     4860

acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg gccgggactt     4920

gtggggtcct tctcctgtca ctggttatca ccctttacag gagtaagagg agcaggctcc     4980

tgcacagtga ctacatgaac atgactcccc gccgccccgg gcccacccgc aagcattacc     5040

agccctatgc cccaccacgc gacttcgcag cctatcgctc caaacggggc agaaagaaac     5100

tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa gaggaagatg     5160

gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga gtgaagttca     5220

gcaggagcgc agacgccccc gcgtaccagc agggccagaa ccagctctat aacgagctca     5280

atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg gaccctgaga     5340

tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag     5400

ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg aggggcaagg     5460

ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac gacgcccttc     5520

acatgcaggc cctgccccct cgctaatgag tcgacggtac ctttaagacc aatgacttac     5580

aaggcagctg tagatcttag ccacttttta aaagaaaagg ggggactgga agggctaatt     5640

cactcccaaa gaagacaaga tctgcttttt gcctgtactg ggtctctctg gttagaccag     5700

atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc tcaataaagc     5760

ttgccttgag tgcttcaatg tgtgtgttgg ttttttgtgt gtcgaaattc tagcgattct     5820

agcttggcgt aatcatggtc atagctgttt cctgtgtgaa attgttatcc gctcacaatt     5880

ccacacaaca tacgagccgg aagcataaag tgtaaagcct ggggtgccta atgagtgagc     5940

taactcacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc     6000

cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct     6060

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca     6120

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac     6180

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt     6240

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg     6300

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc     6360

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc     6420

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc     6480

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac     6540

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt     6600

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct     6660

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc     6720

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt     6780

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg     6840

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc     6900

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa     6960

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag     7020

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg     7080

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga     7140

gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag     7200

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa     7260

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc     7320

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca     7380

aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg     7440

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat     7500

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc     7560

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg     7620

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg     7680

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt     7740

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca     7800

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata     7860

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     7920

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     7980

gtgccacctg ggactagctt tttgcaaaag cctaggcctc caaaaaagcc tcctcactac     8040

ttctggaata gctcagaggc cgaggcggcc tcggcctctg cataaataaa aaaaattagt     8100

cagccatggg gcggagaatg ggcggaactg ggcggagtta ggggcgggat gggcggagtt     8160

aggggcggga ctatggttgc tgactaattg agatgagctt gcatgccgac attgattatt     8220

gactagtccc taagaaacca ttcttatcat gacattaacc tataaaaata ggcgtatcac     8280

gaggcccttt cgtc                                                       8294


<210>  4
<211>  7706
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding the CD37t chimeric antigen 
       receptor

<400>  4
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt gcggccgctg gaagggctaa      420

tttggtccca aaaaagacaa gagatccttg atctgtggat ctaccacaca caaggctact      480

tccctgattg gcagaactac acaccagggc cagggatcag atatccactg acctttggat      540

ggtgcttcaa gttagtacca gttgaaccag agcaagtaga agaggccaat gaaggagaga      600

acaacagctt gttacaccct atgagccagc atgggatgga ggacccggag ggagaagtat      660

tagtgtggaa gtttgacagc ctcctagcat ttcgtcacat ggcccgagag ctgcatccgg      720

agtactacaa agactgctga catcgagctt tctacaaggg actttccgct ggggactttc      780

cagggaggtg tggcctgggc gggactgggg agtggcgagc cctcagatgc tacatataag      840

cagctgcttt ttgcctgtac tgggtctctc tggttagacc agatctgagc ctgggagctc      900

tctggctaac tagggaaccc actgcttaag cctcaataaa gcttgccttg agtgctcaaa      960

gtagtgtgtg cccgtctgtt gtgtgactct ggtaactaga gatccctcag acccttttag     1020

tcagtgtgga aaatctctag cagtggcgcc cgaacaggga cttgaaagcg aaagtaaagc     1080

cagaggagat ctctcgacgc aggactcggc ttgctgaagc gcgcacggca agaggcgagg     1140

ggcggcgact ggtgagtacg ccaaaaattt tgactagcgg aggctagaag gagagagtag     1200

ggtgcgagag cgtcggtatt aagcggggga gaattagata aatgggaaaa aattcggtta     1260

aggccagggg gaaagaaaca atataaacta aaacatatag ttagggcaag cagggagcta     1320

gaacgattcg cagttaatcc tggcctttta gagacatcag aaggctgtag acaaatactg     1380

ggacagctac aaccatccct tcagacagga tcagaagaac ttagatcatt atataataca     1440

atagcagtcc tctattgtgt gcatcaaagg atagatgtaa aagacaccaa ggaagcctta     1500

gataagatag aggaagagca aaacaaaagt aagaaaaagg cacagcaagc agcagctgac     1560

acaggaaaca acagccaggt cagccaaaat taccctatag tgcagaacct ccaggggcaa     1620

atggtacatc aggccatatc acctagaact ttaaattaag acagcagtac aaatggcagt     1680

attcatccac aattttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat     1740

agtagacata atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat     1800

tcaaaatttt cgggtttatt acagggacag cagagatcca gtttggaaag gaccagcaaa     1860

gctcctctgg aaaggtgaag gggcagtagt aatacaagat aatagtgaca taaaagtagt     1920

gccaagaaga aaagcaaaga tcatcaggga ttatggaaaa cagatggcag gtgatgattg     1980

tgtggcaagt agacaggatg aggattaaca catggaaaag attagtaaaa caccatagct     2040

ctagagcgat cccgatcttc agacctggag gaggagatat gagggacaat tggagaagtg     2100

aattatataa atataaagta gtaaaaattg aaccattagg agtagcaccc accaaggcaa     2160

agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg ttccttgggt     2220

tcttgggagc agcaggaagc actatgggcg cagcgtcaat gacgctgacg gtacaggcca     2280

gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct attgaggcgc     2340

aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca agaatcctgg     2400

ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc tctggaaaac     2460

tcatttgcac cactgctgtg ccttggaatg ctagttggag taataaatct ctggaacaga     2520

tttggaatca cacgacctgg atggagtggg acagagaaat taacaattac acaagcttgg     2580

taggtttaag aatagttttt gctgtacttt ctatagtgaa tagagttagg cagggatatt     2640

caccattatc gtttcagacc cacctcccaa ccccgagggg acccgacagg cccgaaggaa     2700

tagaagaaga aggtggagag agagacagag acagatccat tcgattagtg aacggatcca     2760

tcgtcgagag gctccggtgc ccgtcagtgg gcagagcgca catcgcccac agtccccgag     2820

aagttggggg gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg cggggtaaac     2880

tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg agggtggggg agaaccgtat     2940

ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc cagaacacag     3000

gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg     3060

ccttgaatta cttccacgcc cctggctgca gtacgtgatt cttgatcccg agcttcgggt     3120

tggaagtggg tgggagagtt cgaggccttg cgcttaagga gccccttcgc ctcgtgcttg     3180

agttgaggcc tggcctgggc gctggggccg ccgcgtgcga atctggtggc accttcgcgc     3240

ctgtctcgct gctttcgata agtctctagc catttaaaat ttttgatgac ctgctgcgac     3300

gctttttttc tggcaagata gtcttgtaaa tgcgggccaa gatctgcaca ctggtatttc     3360

ggtttttggg gccgcgggcg gcgacggggc ccgtgcgtcc cagcgcacat gttcggcgag     3420

gcggggcctg cgagcgcggc caccgagaat cggacggggg tagtctcaag ctggccggcc     3480

tgctctggtg cctggcctcg cgccgccgtg tatcgccccg ccctgggcgg caaggctggc     3540

ccggtcggca ccagttgcgt gagcggaaag atggccgctt cccggccctg ctgcagggag     3600

ctcaaaatgg aggacgcggc gctcgggaga gcgggcgggt gagtcaccca cacaaaggaa     3660

aagggccttt ccgtcctcag ccgtcgcttc atgtgactcc acggagtacc gggcgccgtc     3720

caggcacctc gattagttct cgagcttttg gagtacgtcg tctttaggtt ggggggaggg     3780

gttttatgcg atggagtttc cccacactga gtgggtggag actgaagtta ggccagcttg     3840

gcacttgatg taattctcct tggaatttgc cctttttgag tttggatctt ggttcattct     3900

caagcctcag acagtggttc aaagtttttt tcttccattt caggtgtcgt gagaattagc     3960

acgcgtccgc caccatggcc ttaccagtga ccgccttgct cctgccgctg gccttgctgc     4020

tccacgccgc caggccggac atccagatga ctcagtctcc agcctcccta tctgcatctg     4080

tgggagagac tgtcaccatc acatgtcgaa caagtgaaaa tgtttacagt tatttggctt     4140

ggtatcagca gaaacaggga aaatctcctc agctcctggt ctcttttgca aaaaccttag     4200

cagaaggtgt gccatcaagg ttcagtggca gtggatcagg cacacagttt tctctgaaga     4260

tcagcagcct gcagcctgaa gattctggaa gttatttctg tcaacatcat tccgataatc     4320

cgtggacgtt cggtggaggc accgaactgg agatcaaagg tggcggtggc tcgggcggtg     4380

gtgggtcggg tggcggcgga tcgtcagcgg tccagctgca gcagtctgga cctgagtcgg     4440

aaaagcctgg cgcttcagtg aagatttcct gcaaggcttc tggttactca ttcactggct     4500

acaatatgaa ctgggtgaag cagaataatg gaaagagcct tgagtggatt ggaaatattg     4560

atccttatta tggtggtact acctacaacc ggaagttcaa gggcaaggcc acattgactg     4620

tagacaaatc ctccagcaca gcctacatgc agctcaagag tctgacatct gaggactctg     4680

cagtctatta ctgtgcaaga tcggtcggcc ctatggacta ctggggtcaa ggaacctcag     4740

tcaccgtctc ttctaccacg acgccagcgc cgcgaccacc aacaccggcg cccaccatcg     4800

cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc     4860

acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg gccgggactt     4920

gtggggtcct tctcctgtca ctggttatca ccctttactg agtcgacggt acctttaaga     4980

ccaatgactt acaaggcagc tgtagatctt agccactttt taaaagaaaa ggggggactg     5040

gaagggctaa ttcactccca aagaagacaa gatctgcttt ttgcctgtac tgggtctctc     5100

tggttagacc agatctgagc ctgggagctc tctggctaac tagggaaccc actgcttaag     5160

cctcaataaa gcttgccttg agtgcttcaa tgtgtgtgtt ggttttttgt gtgtcgaaat     5220

tctagcgatt ctagcttggc gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat     5280

ccgctcacaa ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc     5340

taatgagtga gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagtcggga     5400

aacctgtcgt gccagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt     5460

attgggcgct cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg     5520

cgagcggtat cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac     5580

gcaggaaaga acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg     5640

ttgctggcgt ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca     5700

agtcagaggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc     5760

tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc     5820

ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag     5880

gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc     5940

ttatccggta actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca     6000

gcagccactg gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg     6060

aagtggtggc ctaactacgg ctacactaga agaacagtat ttggtatctg cgctctgctg     6120

aagccagtta ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct     6180

ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa     6240

gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa     6300

gggattttgg tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa     6360

tgaagtttta aatcaatcta aagtatatat gagtaaactt ggtctgacag ttaccaatgc     6420

ttaatcagtg aggcacctat ctcagcgatc tgtctatttc gttcatccat agttgcctga     6480

ctccccgtcg tgtagataac tacgatacgg gagggcttac catctggccc cagtgctgca     6540

atgataccgc gagacccacg ctcaccggct ccagatttat cagcaataaa ccagccagcc     6600

ggaagggccg agcgcagaag tggtcctgca actttatccg cctccatcca gtctattaat     6660

tgttgccggg aagctagagt aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc     6720

attgctacag gcatcgtggt gtcacgctcg tcgtttggta tggcttcatt cagctccggt     6780

tcccaacgat caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc     6840

ttcggtcctc cgatcgttgt cagaagtaag ttggccgcag tgttatcact catggttatg     6900

gcagcactgc ataattctct tactgtcatg ccatccgtaa gatgcttttc tgtgactggt     6960

gagtactcaa ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg     7020

gcgtcaatac gggataatac cgcgccacat agcagaactt taaaagtgct catcattgga     7080

aaacgttctt cggggcgaaa actctcaagg atcttaccgc tgttgagatc cagttcgatg     7140

taacccactc gtgcacccaa ctgatcttca gcatctttta ctttcaccag cgtttctggg     7200

tgagcaaaaa caggaaggca aaatgccgca aaaaagggaa taagggcgac acggaaatgt     7260

tgaatactca tactcttcct ttttcaatat tattgaagca tttatcaggg ttattgtctc     7320

atgagcggat acatatttga atgtatttag aaaaataaac aaataggggt tccgcgcaca     7380

tttccccgaa aagtgccacc tgggactagc tttttgcaaa agcctaggcc tccaaaaaag     7440

cctcctcact acttctggaa tagctcagag gccgaggcgg cctcggcctc tgcataaata     7500

aaaaaaatta gtcagccatg gggcggagaa tgggcggaac tgggcggagt taggggcggg     7560

atgggcggag ttaggggcgg gactatggtt gctgactaat tgagatgagc ttgcatgccg     7620

acattgatta ttgactagtc cctaagaaac cattcttatc atgacattaa cctataaaaa     7680

taggcgtatc acgaggccct ttcgtc                                          7706


<210>  5
<211>  8045
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding the CD37-Z chimeric antigen 
       receptor

<400>  5
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt gcggccgctg gaagggctaa      420

tttggtccca aaaaagacaa gagatccttg atctgtggat ctaccacaca caaggctact      480

tccctgattg gcagaactac acaccagggc cagggatcag atatccactg acctttggat      540

ggtgcttcaa gttagtacca gttgaaccag agcaagtaga agaggccaat gaaggagaga      600

acaacagctt gttacaccct atgagccagc atgggatgga ggacccggag ggagaagtat      660

tagtgtggaa gtttgacagc ctcctagcat ttcgtcacat ggcccgagag ctgcatccgg      720

agtactacaa agactgctga catcgagctt tctacaaggg actttccgct ggggactttc      780

cagggaggtg tggcctgggc gggactgggg agtggcgagc cctcagatgc tacatataag      840

cagctgcttt ttgcctgtac tgggtctctc tggttagacc agatctgagc ctgggagctc      900

tctggctaac tagggaaccc actgcttaag cctcaataaa gcttgccttg agtgctcaaa      960

gtagtgtgtg cccgtctgtt gtgtgactct ggtaactaga gatccctcag acccttttag     1020

tcagtgtgga aaatctctag cagtggcgcc cgaacaggga cttgaaagcg aaagtaaagc     1080

cagaggagat ctctcgacgc aggactcggc ttgctgaagc gcgcacggca agaggcgagg     1140

ggcggcgact ggtgagtacg ccaaaaattt tgactagcgg aggctagaag gagagagtag     1200

ggtgcgagag cgtcggtatt aagcggggga gaattagata aatgggaaaa aattcggtta     1260

aggccagggg gaaagaaaca atataaacta aaacatatag ttagggcaag cagggagcta     1320

gaacgattcg cagttaatcc tggcctttta gagacatcag aaggctgtag acaaatactg     1380

ggacagctac aaccatccct tcagacagga tcagaagaac ttagatcatt atataataca     1440

atagcagtcc tctattgtgt gcatcaaagg atagatgtaa aagacaccaa ggaagcctta     1500

gataagatag aggaagagca aaacaaaagt aagaaaaagg cacagcaagc agcagctgac     1560

acaggaaaca acagccaggt cagccaaaat taccctatag tgcagaacct ccaggggcaa     1620

atggtacatc aggccatatc acctagaact ttaaattaag acagcagtac aaatggcagt     1680

attcatccac aattttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat     1740

agtagacata atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat     1800

tcaaaatttt cgggtttatt acagggacag cagagatcca gtttggaaag gaccagcaaa     1860

gctcctctgg aaaggtgaag gggcagtagt aatacaagat aatagtgaca taaaagtagt     1920

gccaagaaga aaagcaaaga tcatcaggga ttatggaaaa cagatggcag gtgatgattg     1980

tgtggcaagt agacaggatg aggattaaca catggaaaag attagtaaaa caccatagct     2040

ctagagcgat cccgatcttc agacctggag gaggagatat gagggacaat tggagaagtg     2100

aattatataa atataaagta gtaaaaattg aaccattagg agtagcaccc accaaggcaa     2160

agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg ttccttgggt     2220

tcttgggagc agcaggaagc actatgggcg cagcgtcaat gacgctgacg gtacaggcca     2280

gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct attgaggcgc     2340

aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca agaatcctgg     2400

ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc tctggaaaac     2460

tcatttgcac cactgctgtg ccttggaatg ctagttggag taataaatct ctggaacaga     2520

tttggaatca cacgacctgg atggagtggg acagagaaat taacaattac acaagcttgg     2580

taggtttaag aatagttttt gctgtacttt ctatagtgaa tagagttagg cagggatatt     2640

caccattatc gtttcagacc cacctcccaa ccccgagggg acccgacagg cccgaaggaa     2700

tagaagaaga aggtggagag agagacagag acagatccat tcgattagtg aacggatcca     2760

tcgtcgagag gctccggtgc ccgtcagtgg gcagagcgca catcgcccac agtccccgag     2820

aagttggggg gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg cggggtaaac     2880

tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg agggtggggg agaaccgtat     2940

ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc cagaacacag     3000

gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg     3060

ccttgaatta cttccacgcc cctggctgca gtacgtgatt cttgatcccg agcttcgggt     3120

tggaagtggg tgggagagtt cgaggccttg cgcttaagga gccccttcgc ctcgtgcttg     3180

agttgaggcc tggcctgggc gctggggccg ccgcgtgcga atctggtggc accttcgcgc     3240

ctgtctcgct gctttcgata agtctctagc catttaaaat ttttgatgac ctgctgcgac     3300

gctttttttc tggcaagata gtcttgtaaa tgcgggccaa gatctgcaca ctggtatttc     3360

ggtttttggg gccgcgggcg gcgacggggc ccgtgcgtcc cagcgcacat gttcggcgag     3420

gcggggcctg cgagcgcggc caccgagaat cggacggggg tagtctcaag ctggccggcc     3480

tgctctggtg cctggcctcg cgccgccgtg tatcgccccg ccctgggcgg caaggctggc     3540

ccggtcggca ccagttgcgt gagcggaaag atggccgctt cccggccctg ctgcagggag     3600

ctcaaaatgg aggacgcggc gctcgggaga gcgggcgggt gagtcaccca cacaaaggaa     3660

aagggccttt ccgtcctcag ccgtcgcttc atgtgactcc acggagtacc gggcgccgtc     3720

caggcacctc gattagttct cgagcttttg gagtacgtcg tctttaggtt ggggggaggg     3780

gttttatgcg atggagtttc cccacactga gtgggtggag actgaagtta ggccagcttg     3840

gcacttgatg taattctcct tggaatttgc cctttttgag tttggatctt ggttcattct     3900

caagcctcag acagtggttc aaagtttttt tcttccattt caggtgtcgt gagaattagc     3960

acgcgtccgc caccatggcc ttaccagtga ccgccttgct cctgccgctg gccttgctgc     4020

tccacgccgc caggccggac atccagatga ctcagtctcc agcctcccta tctgcatctg     4080

tgggagagac tgtcaccatc acatgtcgaa caagtgaaaa tgtttacagt tatttggctt     4140

ggtatcagca gaaacaggga aaatctcctc agctcctggt ctcttttgca aaaaccttag     4200

cagaaggtgt gccatcaagg ttcagtggca gtggatcagg cacacagttt tctctgaaga     4260

tcagcagcct gcagcctgaa gattctggaa gttatttctg tcaacatcat tccgataatc     4320

cgtggacgtt cggtggaggc accgaactgg agatcaaagg tggcggtggc tcgggcggtg     4380

gtgggtcggg tggcggcgga tcgtcagcgg tccagctgca gcagtctgga cctgagtcgg     4440

aaaagcctgg cgcttcagtg aagatttcct gcaaggcttc tggttactca ttcactggct     4500

acaatatgaa ctgggtgaag cagaataatg gaaagagcct tgagtggatt ggaaatattg     4560

atccttatta tggtggtact acctacaacc ggaagttcaa gggcaaggcc acattgactg     4620

tagacaaatc ctccagcaca gcctacatgc agctcaagag tctgacatct gaggactctg     4680

cagtctatta ctgtgcaaga tcggtcggcc ctatggacta ctggggtcaa ggaacctcag     4740

tcaccgtctc ttctaccacg acgccagcgc cgcgaccacc aacaccggcg cccaccatcg     4800

cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc     4860

acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg gccgggactt     4920

gtggggtcct tctcctgtca ctggttatca ccctttacag agtgaagttc agcaggagcg     4980

cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc aatctaggac     5040

gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag atggggggaa     5100

agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa gataagatgg     5160

cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag gggcacgatg     5220

gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt cacatgcagg     5280

ccctgccccc tcgctaatga gtcgacggta cctttaagac caatgactta caaggcagct     5340

gtagatctta gccacttttt aaaagaaaag gggggactgg aagggctaat tcactcccaa     5400

agaagacaag atctgctttt tgcctgtact gggtctctct ggttagacca gatctgagcc     5460

tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag cttgccttga     5520

gtgcttcaat gtgtgtgttg gttttttgtg tgtcgaaatt ctagcgattc tagcttggcg     5580

taatcatggt catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac     5640

atacgagccg gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca     5700

ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat     5760

taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc     5820

tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca     5880

aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca     5940

aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg     6000

ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg     6060

acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt     6120

ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt     6180

tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc     6240

tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt     6300

gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt     6360

agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc     6420

tacactagaa gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa     6480

agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt     6540

tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct     6600

acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta     6660

tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa     6720

agtatatatg agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc     6780

tcagcgatct gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact     6840

acgatacggg agggcttacc atctggcccc agtgctgcaa tgataccgcg agacccacgc     6900

tcaccggctc cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt     6960

ggtcctgcaa ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta     7020

agtagttcgc cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg     7080

tcacgctcgt cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt     7140

acatgatccc ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc     7200

agaagtaagt tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt     7260

actgtcatgc catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc     7320

tgagaatagt gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc     7380

gcgccacata gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa     7440

ctctcaagga tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac     7500

tgatcttcag catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa     7560

aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt     7620

tttcaatatt attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa     7680

tgtatttaga aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct     7740

gggactagct ttttgcaaaa gcctaggcct ccaaaaaagc ctcctcacta cttctggaat     7800

agctcagagg ccgaggcggc ctcggcctct gcataaataa aaaaaattag tcagccatgg     7860

ggcggagaat gggcggaact gggcggagtt aggggcggga tgggcggagt taggggcggg     7920

actatggttg ctgactaatt gagatgagct tgcatgccga cattgattat tgactagtcc     7980

ctaagaaacc attcttatca tgacattaac ctataaaaat aggcgtatca cgaggccctt     8040

tcgtc                                                                 8045


<210>  6
<211>  7469
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding the pBB112 EF1alpha-GFP construct

<400>  6
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt gcggccgctg gaagggctaa      420

tttggtccca aaaaagacaa gagatccttg atctgtggat ctaccacaca caaggctact      480

tccctgattg gcagaactac acaccagggc cagggatcag atatccactg acctttggat      540

ggtgcttcaa gttagtacca gttgaaccag agcaagtaga agaggccaat gaaggagaga      600

acaacagctt gttacaccct atgagccagc atgggatgga ggacccggag ggagaagtat      660

tagtgtggaa gtttgacagc ctcctagcat ttcgtcacat ggcccgagag ctgcatccgg      720

agtactacaa agactgctga catcgagctt tctacaaggg actttccgct ggggactttc      780

cagggaggtg tggcctgggc gggactgggg agtggcgagc cctcagatgc tacatataag      840

cagctgcttt ttgcctgtac tgggtctctc tggttagacc agatctgagc ctgggagctc      900

tctggctaac tagggaaccc actgcttaag cctcaataaa gcttgccttg agtgctcaaa      960

gtagtgtgtg cccgtctgtt gtgtgactct ggtaactaga gatccctcag acccttttag     1020

tcagtgtgga aaatctctag cagtggcgcc cgaacaggga cttgaaagcg aaagtaaagc     1080

cagaggagat ctctcgacgc aggactcggc ttgctgaagc gcgcacggca agaggcgagg     1140

ggcggcgact ggtgagtacg ccaaaaattt tgactagcgg aggctagaag gagagagtag     1200

ggtgcgagag cgtcggtatt aagcggggga gaattagata aatgggaaaa aattcggtta     1260

aggccagggg gaaagaaaca atataaacta aaacatatag ttagggcaag cagggagcta     1320

gaacgattcg cagttaatcc tggcctttta gagacatcag aaggctgtag acaaatactg     1380

ggacagctac aaccatccct tcagacagga tcagaagaac ttagatcatt atataataca     1440

atagcagtcc tctattgtgt gcatcaaagg atagatgtaa aagacaccaa ggaagcctta     1500

gataagatag aggaagagca aaacaaaagt aagaaaaagg cacagcaagc agcagctgac     1560

acaggaaaca acagccaggt cagccaaaat taccctatag tgcagaacct ccaggggcaa     1620

atggtacatc aggccatatc acctagaact ttaaattaag acagcagtac aaatggcagt     1680

attcatccac aattttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat     1740

agtagacata atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat     1800

tcaaaatttt cgggtttatt acagggacag cagagatcca gtttggaaag gaccagcaaa     1860

gctcctctgg aaaggtgaag gggcagtagt aatacaagat aatagtgaca taaaagtagt     1920

gccaagaaga aaagcaaaga tcatcaggga ttatggaaaa cagatggcag gtgatgattg     1980

tgtggcaagt agacaggatg aggattaaca catggaaaag attagtaaaa caccatagct     2040

ctagagcgat cccgatcttc agacctggag gaggagatat gagggacaat tggagaagtg     2100

aattatataa atataaagta gtaaaaattg aaccattagg agtagcaccc accaaggcaa     2160

agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg ttccttgggt     2220

tcttgggagc agcaggaagc actatgggcg cagcgtcaat gacgctgacg gtacaggcca     2280

gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct attgaggcgc     2340

aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca agaatcctgg     2400

ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc tctggaaaac     2460

tcatttgcac cactgctgtg ccttggaatg ctagttggag taataaatct ctggaacaga     2520

tttggaatca cacgacctgg atggagtggg acagagaaat taacaattac acaagcttgg     2580

taggtttaag aatagttttt gctgtacttt ctatagtgaa tagagttagg cagggatatt     2640

caccattatc gtttcagacc cacctcccaa ccccgagggg acccgacagg cccgaaggaa     2700

tagaagaaga aggtggagag agagacagag acagatccat tcgattagtg aacggatcca     2760

tcgtcgagag gctccggtgc ccgtcagtgg gcagagcgca catcgcccac agtccccgag     2820

aagttggggg gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg cggggtaaac     2880

tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg agggtggggg agaaccgtat     2940

ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc cagaacacag     3000

gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg     3060

ccttgaatta cttccacgcc cctggctgca gtacgtgatt cttgatcccg agcttcgggt     3120

tggaagtggg tgggagagtt cgaggccttg cgcttaagga gccccttcgc ctcgtgcttg     3180

agttgaggcc tggcctgggc gctggggccg ccgcgtgcga atctggtggc accttcgcgc     3240

ctgtctcgct gctttcgata agtctctagc catttaaaat ttttgatgac ctgctgcgac     3300

gctttttttc tggcaagata gtcttgtaaa tgcgggccaa gatctgcaca ctggtatttc     3360

ggtttttggg gccgcgggcg gcgacggggc ccgtgcgtcc cagcgcacat gttcggcgag     3420

gcggggcctg cgagcgcggc caccgagaat cggacggggg tagtctcaag ctggccggcc     3480

tgctctggtg cctggcctcg cgccgccgtg tatcgccccg ccctgggcgg caaggctggc     3540

ccggtcggca ccagttgcgt gagcggaaag atggccgctt cccggccctg ctgcagggag     3600

ctcaaaatgg aggacgcggc gctcgggaga gcgggcgggt gagtcaccca cacaaaggaa     3660

aagggccttt ccgtcctcag ccgtcgcttc atgtgactcc acggagtacc gggcgccgtc     3720

caggcacctc gattagttct cgagcttttg gagtacgtcg tctttaggtt ggggggaggg     3780

gttttatgcg atggagtttc cccacactga gtgggtggag actgaagtta ggccagcttg     3840

gcacttgatg taattctcct tggaatttgc cctttttgag tttggatctt ggttcattct     3900

caagcctcag acagtggttc aaagtttttt tcttccattt caggtgtcgt gagaattagc     3960

acgcgtacca tggtgagcaa gggcgaggag ctgttcaccg gggtggtgcc catcctggtc     4020

gagctggacg gcgacgtaaa cggccacaag ttcagcgtgt ccggcgaggg cgagggcgat     4080

gccacctacg gcaagctgac cctgaagttc atctgcacca ccggcaagct gcccgtgccc     4140

tggcccaccc tcgtgaccac cctgacctac ggcgtgcagt gcttcagccg ctaccccgac     4200

cacatgaagc agcacgactt cttcaagtcc gccatgcccg aaggctacgt ccaggagcgc     4260

accatcttct tcaaggacga cggcaactac aagacccgcg ccgaggtgaa gttcgagggc     4320

gacaccctgg tgaaccgcat cgagctgaag ggcatcgact tcaaggagga cggcaacatc     4380

ctggggcaca agctggagta caactacaac agccacaacg tctatatcat ggccgacaag     4440

cagaagaacg gcatcaaggt gaacttcaag atccgccaca acatcgagga cggcagcgtg     4500

cagctcgccg accactacca gcagaacacc cccatcggcg acggccccgt gctgctgccc     4560

gacaaccact acctgagcac ccagtccgcc ctgagcaaag accccaacga gaagcgcgat     4620

cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat ggacgagctg     4680

tacaagtaaa gcggccaact cgacgttatt cccttcgaag gaaacctgca ggtaccttta     4740

agaccaatga cttacaaggc agctgtagat cttagccact ttttaaaaga aaagggggga     4800

ctggaagggc taattcactc ccaaagaaga caagatctgc tttttgcctg tactgggtct     4860

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt     4920

aagcctcaat aaagcttgcc ttgagtgctt caatgtgtgt gttggttttt tgtgtgtcga     4980

aattctagcg attctagctt ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt     5040

tatccgctca caattccaca caacatacga gccggaagca taaagtgtaa agcctggggt     5100

gcctaatgag tgagctaact cacattaatt gcgttgcgct cactgcccgc tttccagtcg     5160

ggaaacctgt cgtgccagct gcattaatga atcggccaac gcgcggggag aggcggtttg     5220

cgtattgggc gctcttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg     5280

cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat     5340

aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc     5400

gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc     5460

tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga     5520

agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt     5580

ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg     5640

taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc     5700

gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg     5760

gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc     5820

ttgaagtggt ggcctaacta cggctacact agaagaacag tatttggtat ctgcgctctg     5880

ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc     5940

gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct     6000

caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt     6060

taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa     6120

aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa     6180

tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc     6240

tgactccccg tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct     6300

gcaatgatac cgcgagaccc acgctcaccg gctccagatt tatcagcaat aaaccagcca     6360

gccggaaggg ccgagcgcag aagtggtcct gcaactttat ccgcctccat ccagtctatt     6420

aattgttgcc gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt     6480

gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc     6540

ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc     6600

tccttcggtc ctccgatcgt tgtcagaagt aagttggccg cagtgttatc actcatggtt     6660

atggcagcac tgcataattc tcttactgtc atgccatccg taagatgctt ttctgtgact     6720

ggtgagtact caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc     6780

ccggcgtcaa tacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt     6840

ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg     6900

atgtaaccca ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct     6960

gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa     7020

tgttgaatac tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt     7080

ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc     7140

acatttcccc gaaaagtgcc acctgggact agctttttgc aaaagcctag gcctccaaaa     7200

aagcctcctc actacttctg gaatagctca gaggccgagg cggcctcggc ctctgcataa     7260

ataaaaaaaa ttagtcagcc atggggcgga gaatgggcgg aactgggcgg agttaggggc     7320

gggatgggcg gagttagggg cgggactatg gttgctgact aattgagatg agcttgcatg     7380

ccgacattga ttattgacta gtccctaaga aaccattctt atcatgacat taacctataa     7440

aaataggcgt atcacgaggc cctttcgtc                                       7469


