                         SEQUENCE LISTING

<110>  Novozymes A/S
       Fukuyama, Shiro
       Tsutsumi, Noriko
       Coward-Kelly, Guillermo
       Ayabe, Keiichi
 
<120>  Aspergillus terreus amylase hybrids

<130>  12322-WO-PCT

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  1821
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hybrid


<220>
<221>  sig_peptide
<222>  (1)..(63)

<220>
<221>  CDS
<222>  (1)..(1818)

<220>
<221>  mat_peptide
<222>  (64)..(1818)

<400>  1
atg aga tta tcg act tcg agt ctc ttc ctt tcc gtg tct ctg ctg ggg         48
Met Arg Leu Ser Thr Ser Ser Leu Phe Leu Ser Val Ser Leu Leu Gly           
    -20                 -15                 -10                           

aag ctg gcc ctc ggg ctg acc cca gca gaa tgg cgc agc cag tca atc         96
Lys Leu Ala Leu Gly Leu Thr Pro Ala Glu Trp Arg Ser Gln Ser Ile           
-5              -1  1               5                   10                

tac ttc ctg ttg acc gat cgc ttt ggt cga acg gac aat tcc aca act        144
Tyr Phe Leu Leu Thr Asp Arg Phe Gly Arg Thr Asp Asn Ser Thr Thr           
            15                  20                  25                    

gcc gct tgc gat acc tct gac aga gta tac tgc ggt ggt agc tgg cag        192
Ala Ala Cys Asp Thr Ser Asp Arg Val Tyr Cys Gly Gly Ser Trp Gln           
        30                  35                  40                        

gga atc atc aac caa ctc gat tac atc caa ggg atg gga ttc act gcc        240
Gly Ile Ile Asn Gln Leu Asp Tyr Ile Gln Gly Met Gly Phe Thr Ala           
    45                  50                  55                            

atc tgg atc acc ccg gtc act gga cag ttc tac gaa aac acg ggc gac        288
Ile Trp Ile Thr Pro Val Thr Gly Gln Phe Tyr Glu Asn Thr Gly Asp           
60                  65                  70                  75            

ggc acc tct tac cat gga tac tgg cag cag gac atc tac gat ctc aac        336
Gly Thr Ser Tyr His Gly Tyr Trp Gln Gln Asp Ile Tyr Asp Leu Asn           
                80                  85                  90                

tac aac tac gga acg gcc caa gac ctc aag aac cta gcc aat gct ttg        384
Tyr Asn Tyr Gly Thr Ala Gln Asp Leu Lys Asn Leu Ala Asn Ala Leu           
            95                  100                 105                   

cac gag cgc ggc atg tat ttg atg gtt gat gtg gtt gcc aac cac atg        432
His Glu Arg Gly Met Tyr Leu Met Val Asp Val Val Ala Asn His Met           
        110                 115                 120                       

ggc tat gac gga gcg gga aac acc gtg gac tac agt gtt ttc aac ccc        480
Gly Tyr Asp Gly Ala Gly Asn Thr Val Asp Tyr Ser Val Phe Asn Pro           
    125                 130                 135                           

ttc tcc tcc tcc tcc tac ttt cac cca tac tgc ctc atc tcc aat tac        528
Phe Ser Ser Ser Ser Tyr Phe His Pro Tyr Cys Leu Ile Ser Asn Tyr           
140                 145                 150                 155           

gac aac cag acc aat gtt gaa gac tgc tgg ctg ggc gat acc acc gtt        576
Asp Asn Gln Thr Asn Val Glu Asp Cys Trp Leu Gly Asp Thr Thr Val           
                160                 165                 170               

tcg ctg cca gat ctc gac acg aca agc aca gcc gtg cgg aac atc tgg        624
Ser Leu Pro Asp Leu Asp Thr Thr Ser Thr Ala Val Arg Asn Ile Trp           
            175                 180                 185                   

tac gac tgg gtg gca gat ttg gtc gcc aac tat tct atc gac ggt ctg        672
Tyr Asp Trp Val Ala Asp Leu Val Ala Asn Tyr Ser Ile Asp Gly Leu           
        190                 195                 200                       

cgt gtc gac act gta aaa cac gtc gaa aaa gac ttt tgg ccc ggc tat        720
Arg Val Asp Thr Val Lys His Val Glu Lys Asp Phe Trp Pro Gly Tyr           
    205                 210                 215                           

aac agc gca gca ggc gtc tac tgt gtc ggc gag gtc tac tca ggc gat        768
Asn Ser Ala Ala Gly Val Tyr Cys Val Gly Glu Val Tyr Ser Gly Asp           
220                 225                 230                 235           

cct gca tac aca tgc ccg tac cag aac tac atg gac ggt gtg ctc aac        816
Pro Ala Tyr Thr Cys Pro Tyr Gln Asn Tyr Met Asp Gly Val Leu Asn           
                240                 245                 250               

tat cca att tac tac cag ctt ctc tat gcg ttt gag tcg tcc agc ggc        864
Tyr Pro Ile Tyr Tyr Gln Leu Leu Tyr Ala Phe Glu Ser Ser Ser Gly           
            255                 260                 265                   

agc atc agc gat ctc tac aac atg atc agc tcc gtt gcc tcc agc tgc        912
Ser Ile Ser Asp Leu Tyr Asn Met Ile Ser Ser Val Ala Ser Ser Cys           
        270                 275                 280                       

aag gat ccc aca ctc ctg ggg aac ttc atc gag aac cac gat aac ccc        960
Lys Asp Pro Thr Leu Leu Gly Asn Phe Ile Glu Asn His Asp Asn Pro           
    285                 290                 295                           

cgc ttc gct tcc tac acg agc gac tac tcg cag gct aag aac gtg atc       1008
Arg Phe Ala Ser Tyr Thr Ser Asp Tyr Ser Gln Ala Lys Asn Val Ile           
300                 305                 310                 315           

acc ttc atc ttc ctg agc gac ggt atc ccc atc gtc tac gcc gga cag       1056
Thr Phe Ile Phe Leu Ser Asp Gly Ile Pro Ile Val Tyr Ala Gly Gln           
                320                 325                 330               

gaa cag cac tac agc gga ggc agc gac cca gct aac cgc gag gcc acc       1104
Glu Gln His Tyr Ser Gly Gly Ser Asp Pro Ala Asn Arg Glu Ala Thr           
            335                 340                 345                   

tgg ctg tcc gga tac tcc acc agc gct acg ctg tac acc tgg atc gcc       1152
Trp Leu Ser Gly Tyr Ser Thr Ser Ala Thr Leu Tyr Thr Trp Ile Ala           
        350                 355                 360                       

acc aca aac cag atc cgc agc ctg gcg atc tcc aag gac gcg gga tac       1200
Thr Thr Asn Gln Ile Arg Ser Leu Ala Ile Ser Lys Asp Ala Gly Tyr           
    365                 370                 375                           

gtg cag gcc aag aac aac ccc ttc tac tcc gac tcc aac acc atc gcc       1248
Val Gln Ala Lys Asn Asn Pro Phe Tyr Ser Asp Ser Asn Thr Ile Ala           
380                 385                 390                 395           

atg cgc aag ggc acg aca gcc ggc gcg caa gtc atc acc gtc ctc agc       1296
Met Arg Lys Gly Thr Thr Ala Gly Ala Gln Val Ile Thr Val Leu Ser           
                400                 405                 410               

aac aag ggc gcc tcc ggc agc tcc tac act ctc tct ttg agt ggt acc       1344
Asn Lys Gly Ala Ser Gly Ser Ser Tyr Thr Leu Ser Leu Ser Gly Thr           
            415                 420                 425                   

ggc tac tcc gcc ggc gtg acc ctg gtc gag acg tac acc tgc acc acg       1392
Gly Tyr Ser Ala Gly Val Thr Leu Val Glu Thr Tyr Thr Cys Thr Thr           
        430                 435                 440                       

gtg act gta gac tcg agc ggc aac ctg ccc gtc cca atg aca tcc ggc       1440
Val Thr Val Asp Ser Ser Gly Asn Leu Pro Val Pro Met Thr Ser Gly           
    445                 450                 455                           

ttg ccg cga gtg ttt gtc ccg tcg tcc tgg gtg aat ggg agc gcg ctt       1488
Leu Pro Arg Val Phe Val Pro Ser Ser Trp Val Asn Gly Ser Ala Leu           
460                 465                 470                 475           

tgc aac ggt gct aca agc ccg ggt ggc tcc tcg ggt agt gtc gag gtc       1536
Cys Asn Gly Ala Thr Ser Pro Gly Gly Ser Ser Gly Ser Val Glu Val           
                480                 485                 490               

act ttc gac gtt tac gct acc aca gta tat ggc cag aac atc tat atc       1584
Thr Phe Asp Val Tyr Ala Thr Thr Val Tyr Gly Gln Asn Ile Tyr Ile           
            495                 500                 505                   

acc ggt gat gtg agt gag ctc ggc aac tgg aca ccc gcc aat ggt gtt       1632
Thr Gly Asp Val Ser Glu Leu Gly Asn Trp Thr Pro Ala Asn Gly Val           
        510                 515                 520                       

gca ctc tct tct gct aac tac ccc acc tgg agt gcc acg atc gct ctc       1680
Ala Leu Ser Ser Ala Asn Tyr Pro Thr Trp Ser Ala Thr Ile Ala Leu           
    525                 530                 535                           

ccc gct gac acg aca atc cag tac aag tat gtc aac att gac ggc agc       1728
Pro Ala Asp Thr Thr Ile Gln Tyr Lys Tyr Val Asn Ile Asp Gly Ser           
540                 545                 550                 555           

acc gtc atc tgg gag gat gct atc agc aat cgc gag atc acg acg ccc       1776
Thr Val Ile Trp Glu Asp Ala Ile Ser Asn Arg Glu Ile Thr Thr Pro           
                560                 565                 570               

gcc agc ggc aca tac acc gaa aaa gac act tgg gat gaa tct tag           1821
Ala Ser Gly Thr Tyr Thr Glu Lys Asp Thr Trp Asp Glu Ser                   
            575                 580                 585                   


<210>  2
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Arg Leu Ser Thr Ser Ser Leu Phe Leu Ser Val Ser Leu Leu Gly 
    -20                 -15                 -10                 


Lys Leu Ala Leu Gly Leu Thr Pro Ala Glu Trp Arg Ser Gln Ser Ile 
-5              -1  1               5                   10      


Tyr Phe Leu Leu Thr Asp Arg Phe Gly Arg Thr Asp Asn Ser Thr Thr 
            15                  20                  25          


Ala Ala Cys Asp Thr Ser Asp Arg Val Tyr Cys Gly Gly Ser Trp Gln 
        30                  35                  40              


Gly Ile Ile Asn Gln Leu Asp Tyr Ile Gln Gly Met Gly Phe Thr Ala 
    45                  50                  55                  


Ile Trp Ile Thr Pro Val Thr Gly Gln Phe Tyr Glu Asn Thr Gly Asp 
60                  65                  70                  75  


Gly Thr Ser Tyr His Gly Tyr Trp Gln Gln Asp Ile Tyr Asp Leu Asn 
                80                  85                  90      


Tyr Asn Tyr Gly Thr Ala Gln Asp Leu Lys Asn Leu Ala Asn Ala Leu 
            95                  100                 105         


His Glu Arg Gly Met Tyr Leu Met Val Asp Val Val Ala Asn His Met 
        110                 115                 120             


Gly Tyr Asp Gly Ala Gly Asn Thr Val Asp Tyr Ser Val Phe Asn Pro 
    125                 130                 135                 


Phe Ser Ser Ser Ser Tyr Phe His Pro Tyr Cys Leu Ile Ser Asn Tyr 
140                 145                 150                 155 


Asp Asn Gln Thr Asn Val Glu Asp Cys Trp Leu Gly Asp Thr Thr Val 
                160                 165                 170     


Ser Leu Pro Asp Leu Asp Thr Thr Ser Thr Ala Val Arg Asn Ile Trp 
            175                 180                 185         


Tyr Asp Trp Val Ala Asp Leu Val Ala Asn Tyr Ser Ile Asp Gly Leu 
        190                 195                 200             


Arg Val Asp Thr Val Lys His Val Glu Lys Asp Phe Trp Pro Gly Tyr 
    205                 210                 215                 


Asn Ser Ala Ala Gly Val Tyr Cys Val Gly Glu Val Tyr Ser Gly Asp 
220                 225                 230                 235 


Pro Ala Tyr Thr Cys Pro Tyr Gln Asn Tyr Met Asp Gly Val Leu Asn 
                240                 245                 250     


Tyr Pro Ile Tyr Tyr Gln Leu Leu Tyr Ala Phe Glu Ser Ser Ser Gly 
            255                 260                 265         


Ser Ile Ser Asp Leu Tyr Asn Met Ile Ser Ser Val Ala Ser Ser Cys 
        270                 275                 280             


Lys Asp Pro Thr Leu Leu Gly Asn Phe Ile Glu Asn His Asp Asn Pro 
    285                 290                 295                 


Arg Phe Ala Ser Tyr Thr Ser Asp Tyr Ser Gln Ala Lys Asn Val Ile 
300                 305                 310                 315 


Thr Phe Ile Phe Leu Ser Asp Gly Ile Pro Ile Val Tyr Ala Gly Gln 
                320                 325                 330     


Glu Gln His Tyr Ser Gly Gly Ser Asp Pro Ala Asn Arg Glu Ala Thr 
            335                 340                 345         


Trp Leu Ser Gly Tyr Ser Thr Ser Ala Thr Leu Tyr Thr Trp Ile Ala 
        350                 355                 360             


Thr Thr Asn Gln Ile Arg Ser Leu Ala Ile Ser Lys Asp Ala Gly Tyr 
    365                 370                 375                 


Val Gln Ala Lys Asn Asn Pro Phe Tyr Ser Asp Ser Asn Thr Ile Ala 
380                 385                 390                 395 


Met Arg Lys Gly Thr Thr Ala Gly Ala Gln Val Ile Thr Val Leu Ser 
                400                 405                 410     


Asn Lys Gly Ala Ser Gly Ser Ser Tyr Thr Leu Ser Leu Ser Gly Thr 
            415                 420                 425         


Gly Tyr Ser Ala Gly Val Thr Leu Val Glu Thr Tyr Thr Cys Thr Thr 
        430                 435                 440             


Val Thr Val Asp Ser Ser Gly Asn Leu Pro Val Pro Met Thr Ser Gly 
    445                 450                 455                 


Leu Pro Arg Val Phe Val Pro Ser Ser Trp Val Asn Gly Ser Ala Leu 
460                 465                 470                 475 


Cys Asn Gly Ala Thr Ser Pro Gly Gly Ser Ser Gly Ser Val Glu Val 
                480                 485                 490     


Thr Phe Asp Val Tyr Ala Thr Thr Val Tyr Gly Gln Asn Ile Tyr Ile 
            495                 500                 505         


Thr Gly Asp Val Ser Glu Leu Gly Asn Trp Thr Pro Ala Asn Gly Val 
        510                 515                 520             


Ala Leu Ser Ser Ala Asn Tyr Pro Thr Trp Ser Ala Thr Ile Ala Leu 
    525                 530                 535                 


Pro Ala Asp Thr Thr Ile Gln Tyr Lys Tyr Val Asn Ile Asp Gly Ser 
540                 545                 550                 555 


Thr Val Ile Trp Glu Asp Ala Ile Ser Asn Arg Glu Ile Thr Thr Pro 
                560                 565                 570     


Ala Ser Gly Thr Tyr Thr Glu Lys Asp Thr Trp Asp Glu Ser 
            575                 580                 585 


<210>  3
<211>  1932
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hybrid


<220>
<221>  sig_peptide
<222>  (1)..(63)

<220>
<221>  CDS
<222>  (1)..(1929)

<220>
<221>  mat_peptide
<222>  (64)..(1929)

<400>  3
atg aga tta tcg act tcg agt ctc ttc ctt tcc gtg tct ctg ctg ggg         48
Met Arg Leu Ser Thr Ser Ser Leu Phe Leu Ser Val Ser Leu Leu Gly           
    -20                 -15                 -10                           

aag ctg gcc ctc ggg ctg acc cca gca gaa tgg cgc agc cag tca atc         96
Lys Leu Ala Leu Gly Leu Thr Pro Ala Glu Trp Arg Ser Gln Ser Ile           
-5              -1  1               5                   10                

tac ttc ctg ttg acc gat cgc ttt ggt cga acg gac aat tcc aca act        144
Tyr Phe Leu Leu Thr Asp Arg Phe Gly Arg Thr Asp Asn Ser Thr Thr           
            15                  20                  25                    

gcc gct tgc gat acc tct gac aga gta tac tgc ggt ggt agc tgg cag        192
Ala Ala Cys Asp Thr Ser Asp Arg Val Tyr Cys Gly Gly Ser Trp Gln           
        30                  35                  40                        

gga atc atc aac caa ctc gat tac atc caa ggg atg gga ttc act gcc        240
Gly Ile Ile Asn Gln Leu Asp Tyr Ile Gln Gly Met Gly Phe Thr Ala           
    45                  50                  55                            

atc tgg atc acc ccg gtc act gga cag ttc tac gaa aac acg ggc gac        288
Ile Trp Ile Thr Pro Val Thr Gly Gln Phe Tyr Glu Asn Thr Gly Asp           
60                  65                  70                  75            

ggc acc tct tac cat gga tac tgg cag cag gac atc tac gat ctc aac        336
Gly Thr Ser Tyr His Gly Tyr Trp Gln Gln Asp Ile Tyr Asp Leu Asn           
                80                  85                  90                

tac aac tac gga acg gcc caa gac ctc aag aac cta gcc aat gct ttg        384
Tyr Asn Tyr Gly Thr Ala Gln Asp Leu Lys Asn Leu Ala Asn Ala Leu           
            95                  100                 105                   

cac gag cgc ggc atg tat ttg atg gtt gat gtg gtt gcc aac cac atg        432
His Glu Arg Gly Met Tyr Leu Met Val Asp Val Val Ala Asn His Met           
        110                 115                 120                       

ggc tat gac gga gcg gga aac acc gtg gac tac agt gtt ttc aac ccc        480
Gly Tyr Asp Gly Ala Gly Asn Thr Val Asp Tyr Ser Val Phe Asn Pro           
    125                 130                 135                           

ttc tcc tcc tcc tcc tac ttt cac cca tac tgc ctc atc tcc aat tac        528
Phe Ser Ser Ser Ser Tyr Phe His Pro Tyr Cys Leu Ile Ser Asn Tyr           
140                 145                 150                 155           

gac aac cag acc aat gtt gaa gac tgc tgg ctg ggc gat acc acc gtt        576
Asp Asn Gln Thr Asn Val Glu Asp Cys Trp Leu Gly Asp Thr Thr Val           
                160                 165                 170               

tcg ctg cca gat ctc gac acg aca agc aca gcc gtg cgg aac atc tgg        624
Ser Leu Pro Asp Leu Asp Thr Thr Ser Thr Ala Val Arg Asn Ile Trp           
            175                 180                 185                   

tac gac tgg gtg gca gat ttg gtc gcc aac tat tct atc gac ggt ctg        672
Tyr Asp Trp Val Ala Asp Leu Val Ala Asn Tyr Ser Ile Asp Gly Leu           
        190                 195                 200                       

cgt gtc gac act gta aaa cac gtc gaa aaa gac ttt tgg ccc ggc tat        720
Arg Val Asp Thr Val Lys His Val Glu Lys Asp Phe Trp Pro Gly Tyr           
    205                 210                 215                           

aac agc gca gca ggc gtc tac tgt gtc ggc gag gtc tac tca ggc gat        768
Asn Ser Ala Ala Gly Val Tyr Cys Val Gly Glu Val Tyr Ser Gly Asp           
220                 225                 230                 235           

cct gca tac aca tgc ccg tac cag aac tac atg gac ggt gtg ctc aac        816
Pro Ala Tyr Thr Cys Pro Tyr Gln Asn Tyr Met Asp Gly Val Leu Asn           
                240                 245                 250               

tat cca att tac tac cag ctt ctc tat gcg ttt gag tcg tcc agc ggc        864
Tyr Pro Ile Tyr Tyr Gln Leu Leu Tyr Ala Phe Glu Ser Ser Ser Gly           
            255                 260                 265                   

agc atc agc gat ctc tac aac atg atc agc tcc gtt gcc tcc agc tgc        912
Ser Ile Ser Asp Leu Tyr Asn Met Ile Ser Ser Val Ala Ser Ser Cys           
        270                 275                 280                       

aag gat ccc aca ctc ctg ggg aac ttc atc gag aac cac gat aac ccc        960
Lys Asp Pro Thr Leu Leu Gly Asn Phe Ile Glu Asn His Asp Asn Pro           
    285                 290                 295                           

cgc ttc gct tcc tac acg agc gac tac tcg cag gct aag aac gtg atc       1008
Arg Phe Ala Ser Tyr Thr Ser Asp Tyr Ser Gln Ala Lys Asn Val Ile           
300                 305                 310                 315           

acc ttc atc ttc ctg agc gac ggt atc ccc atc gtc tac gcc gga cag       1056
Thr Phe Ile Phe Leu Ser Asp Gly Ile Pro Ile Val Tyr Ala Gly Gln           
                320                 325                 330               

gaa cag cac tac agc gga ggc agc gac cca gct aac cgc gag gcc acc       1104
Glu Gln His Tyr Ser Gly Gly Ser Asp Pro Ala Asn Arg Glu Ala Thr           
            335                 340                 345                   

tgg ctg tcc gga tac tcc acc agc gct acg ctg tac acc tgg atc gcc       1152
Trp Leu Ser Gly Tyr Ser Thr Ser Ala Thr Leu Tyr Thr Trp Ile Ala           
        350                 355                 360                       

acc aca aac cag atc cgc agc ctg gcg atc tcc aag gac gcg gga tac       1200
Thr Thr Asn Gln Ile Arg Ser Leu Ala Ile Ser Lys Asp Ala Gly Tyr           
    365                 370                 375                           

gtg cag gcc aag aac aac ccc ttc tac tcc gac tcc aac acc atc gcc       1248
Val Gln Ala Lys Asn Asn Pro Phe Tyr Ser Asp Ser Asn Thr Ile Ala           
380                 385                 390                 395           

atg cgc aag ggc acg aca gcc ggc gcg caa gtc atc acc gtc ctc agc       1296
Met Arg Lys Gly Thr Thr Ala Gly Ala Gln Val Ile Thr Val Leu Ser           
                400                 405                 410               

aac aag ggc gcc tcc ggc agc tcc tac act ctc tct ttg agt ggt acc       1344
Asn Lys Gly Ala Ser Gly Ser Ser Tyr Thr Leu Ser Leu Ser Gly Thr           
            415                 420                 425                   

ggc tac tcc gcc ggc gtg acc ctg gtc gag acg tac acc tgc acc acg       1392
Gly Tyr Ser Ala Gly Val Thr Leu Val Glu Thr Tyr Thr Cys Thr Thr           
        430                 435                 440                       

gtg act gta gac tcg agc ggc aac ctg ccc gtc cca atg aca tcc ggc       1440
Val Thr Val Asp Ser Ser Gly Asn Leu Pro Val Pro Met Thr Ser Gly           
    445                 450                 455                           

ttg ccg cga gtg ttt gtc ccg tcg tcc tgg gtg aat ggg agc gcg ctt       1488
Leu Pro Arg Val Phe Val Pro Ser Ser Trp Val Asn Gly Ser Ala Leu           
460                 465                 470                 475           

tgc aac act ggc ggc acc act acg acg gct acc ccc act ggc tcc ggc       1536
Cys Asn Thr Gly Gly Thr Thr Thr Thr Ala Thr Pro Thr Gly Ser Gly           
                480                 485                 490               

agc gtg acc tcg acc agc aag acc acc gcg act gcc agc aag acc agc       1584
Ser Val Thr Ser Thr Ser Lys Thr Thr Ala Thr Ala Ser Lys Thr Ser           
            495                 500                 505                   

acc agt acg tca tca acc tcc tgt acc act ccc acc gcc gtg gct gtg       1632
Thr Ser Thr Ser Ser Thr Ser Cys Thr Thr Pro Thr Ala Val Ala Val           
        510                 515                 520                       

act ttc gat ctg aca gct acc acc acc tac ggc gag aac atc tac ctg       1680
Thr Phe Asp Leu Thr Ala Thr Thr Thr Tyr Gly Glu Asn Ile Tyr Leu           
    525                 530                 535                           

gtc gga tcg atc tct cag ctg ggt gac tgg gaa acc agc gac ggc ata       1728
Val Gly Ser Ile Ser Gln Leu Gly Asp Trp Glu Thr Ser Asp Gly Ile           
540                 545                 550                 555           

gct ctg agt gct gac aag tac act tcc agc gac ccg ctc tgg tat gtc       1776
Ala Leu Ser Ala Asp Lys Tyr Thr Ser Ser Asp Pro Leu Trp Tyr Val           
                560                 565                 570               

act gtg act ctg ccg gct ggt gag tcg ttt gag tac aag ttt atc cgc       1824
Thr Val Thr Leu Pro Ala Gly Glu Ser Phe Glu Tyr Lys Phe Ile Arg           
            575                 580                 585                   

att gag agc gat gac tcc gtg gag tgg gag agt gat ccc aac cga gaa       1872
Ile Glu Ser Asp Asp Ser Val Glu Trp Glu Ser Asp Pro Asn Arg Glu           
        590                 595                 600                       

tac acc gtt cct cag gcg tgc gga acg tcg acc gcg acg gtg act gac       1920
Tyr Thr Val Pro Gln Ala Cys Gly Thr Ser Thr Ala Thr Val Thr Asp           
    605                 610                 615                           

acc tgg cgg tag                                                       1932
Thr Trp Arg                                                               
620                                                                       


<210>  4
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Arg Leu Ser Thr Ser Ser Leu Phe Leu Ser Val Ser Leu Leu Gly 
    -20                 -15                 -10                 


Lys Leu Ala Leu Gly Leu Thr Pro Ala Glu Trp Arg Ser Gln Ser Ile 
-5              -1  1               5                   10      


Tyr Phe Leu Leu Thr Asp Arg Phe Gly Arg Thr Asp Asn Ser Thr Thr 
            15                  20                  25          


Ala Ala Cys Asp Thr Ser Asp Arg Val Tyr Cys Gly Gly Ser Trp Gln 
        30                  35                  40              


Gly Ile Ile Asn Gln Leu Asp Tyr Ile Gln Gly Met Gly Phe Thr Ala 
    45                  50                  55                  


Ile Trp Ile Thr Pro Val Thr Gly Gln Phe Tyr Glu Asn Thr Gly Asp 
60                  65                  70                  75  


Gly Thr Ser Tyr His Gly Tyr Trp Gln Gln Asp Ile Tyr Asp Leu Asn 
                80                  85                  90      


Tyr Asn Tyr Gly Thr Ala Gln Asp Leu Lys Asn Leu Ala Asn Ala Leu 
            95                  100                 105         


His Glu Arg Gly Met Tyr Leu Met Val Asp Val Val Ala Asn His Met 
        110                 115                 120             


Gly Tyr Asp Gly Ala Gly Asn Thr Val Asp Tyr Ser Val Phe Asn Pro 
    125                 130                 135                 


Phe Ser Ser Ser Ser Tyr Phe His Pro Tyr Cys Leu Ile Ser Asn Tyr 
140                 145                 150                 155 


Asp Asn Gln Thr Asn Val Glu Asp Cys Trp Leu Gly Asp Thr Thr Val 
                160                 165                 170     


Ser Leu Pro Asp Leu Asp Thr Thr Ser Thr Ala Val Arg Asn Ile Trp 
            175                 180                 185         


Tyr Asp Trp Val Ala Asp Leu Val Ala Asn Tyr Ser Ile Asp Gly Leu 
        190                 195                 200             


Arg Val Asp Thr Val Lys His Val Glu Lys Asp Phe Trp Pro Gly Tyr 
    205                 210                 215                 


Asn Ser Ala Ala Gly Val Tyr Cys Val Gly Glu Val Tyr Ser Gly Asp 
220                 225                 230                 235 


Pro Ala Tyr Thr Cys Pro Tyr Gln Asn Tyr Met Asp Gly Val Leu Asn 
                240                 245                 250     


Tyr Pro Ile Tyr Tyr Gln Leu Leu Tyr Ala Phe Glu Ser Ser Ser Gly 
            255                 260                 265         


Ser Ile Ser Asp Leu Tyr Asn Met Ile Ser Ser Val Ala Ser Ser Cys 
        270                 275                 280             


Lys Asp Pro Thr Leu Leu Gly Asn Phe Ile Glu Asn His Asp Asn Pro 
    285                 290                 295                 


Arg Phe Ala Ser Tyr Thr Ser Asp Tyr Ser Gln Ala Lys Asn Val Ile 
300                 305                 310                 315 


Thr Phe Ile Phe Leu Ser Asp Gly Ile Pro Ile Val Tyr Ala Gly Gln 
                320                 325                 330     


Glu Gln His Tyr Ser Gly Gly Ser Asp Pro Ala Asn Arg Glu Ala Thr 
            335                 340                 345         


Trp Leu Ser Gly Tyr Ser Thr Ser Ala Thr Leu Tyr Thr Trp Ile Ala 
        350                 355                 360             


Thr Thr Asn Gln Ile Arg Ser Leu Ala Ile Ser Lys Asp Ala Gly Tyr 
    365                 370                 375                 


Val Gln Ala Lys Asn Asn Pro Phe Tyr Ser Asp Ser Asn Thr Ile Ala 
380                 385                 390                 395 


Met Arg Lys Gly Thr Thr Ala Gly Ala Gln Val Ile Thr Val Leu Ser 
                400                 405                 410     


Asn Lys Gly Ala Ser Gly Ser Ser Tyr Thr Leu Ser Leu Ser Gly Thr 
            415                 420                 425         


Gly Tyr Ser Ala Gly Val Thr Leu Val Glu Thr Tyr Thr Cys Thr Thr 
        430                 435                 440             


Val Thr Val Asp Ser Ser Gly Asn Leu Pro Val Pro Met Thr Ser Gly 
    445                 450                 455                 


Leu Pro Arg Val Phe Val Pro Ser Ser Trp Val Asn Gly Ser Ala Leu 
460                 465                 470                 475 


Cys Asn Thr Gly Gly Thr Thr Thr Thr Ala Thr Pro Thr Gly Ser Gly 
                480                 485                 490     


Ser Val Thr Ser Thr Ser Lys Thr Thr Ala Thr Ala Ser Lys Thr Ser 
            495                 500                 505         


Thr Ser Thr Ser Ser Thr Ser Cys Thr Thr Pro Thr Ala Val Ala Val 
        510                 515                 520             


Thr Phe Asp Leu Thr Ala Thr Thr Thr Tyr Gly Glu Asn Ile Tyr Leu 
    525                 530                 535                 


Val Gly Ser Ile Ser Gln Leu Gly Asp Trp Glu Thr Ser Asp Gly Ile 
540                 545                 550                 555 


Ala Leu Ser Ala Asp Lys Tyr Thr Ser Ser Asp Pro Leu Trp Tyr Val 
                560                 565                 570     


Thr Val Thr Leu Pro Ala Gly Glu Ser Phe Glu Tyr Lys Phe Ile Arg 
            575                 580                 585         


Ile Glu Ser Asp Asp Ser Val Glu Trp Glu Ser Asp Pro Asn Arg Glu 
        590                 595                 600             


Tyr Thr Val Pro Gln Ala Cys Gly Thr Ser Thr Ala Thr Val Thr Asp 
    605                 610                 615                 


Thr Trp Arg 
620         


<210>  5
<211>  1887
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hybrid


<220>
<221>  sig_peptide
<222>  (1)..(63)

<220>
<221>  CDS
<222>  (1)..(1884)

<220>
<221>  mat_peptide
<222>  (64)..(1884)

<400>  5
atg aga tta tcg act tcg agt ctc ttc ctt tcc gtg tct ctg ctg ggg         48
Met Arg Leu Ser Thr Ser Ser Leu Phe Leu Ser Val Ser Leu Leu Gly           
    -20                 -15                 -10                           

aag ctg gcc ctc ggg ctg acc cca gca gaa tgg cgc agc cag tca atc         96
Lys Leu Ala Leu Gly Leu Thr Pro Ala Glu Trp Arg Ser Gln Ser Ile           
-5              -1  1               5                   10                

tac ttc ctg ttg acc gat cgc ttt ggt cga acg gac aat tcc aca act        144
Tyr Phe Leu Leu Thr Asp Arg Phe Gly Arg Thr Asp Asn Ser Thr Thr           
            15                  20                  25                    

gcc gct tgc gat acc tct gac aga gta tac tgc ggt ggt agc tgg cag        192
Ala Ala Cys Asp Thr Ser Asp Arg Val Tyr Cys Gly Gly Ser Trp Gln           
        30                  35                  40                        

gga atc atc aac caa ctc gat tac atc caa ggg atg gga ttc act gcc        240
Gly Ile Ile Asn Gln Leu Asp Tyr Ile Gln Gly Met Gly Phe Thr Ala           
    45                  50                  55                            

atc tgg atc acc ccg gtc act gga cag ttc tac gaa aac acg ggc gac        288
Ile Trp Ile Thr Pro Val Thr Gly Gln Phe Tyr Glu Asn Thr Gly Asp           
60                  65                  70                  75            

ggc acc tct tac cat gga tac tgg cag cag gac atc tac gat ctc aac        336
Gly Thr Ser Tyr His Gly Tyr Trp Gln Gln Asp Ile Tyr Asp Leu Asn           
                80                  85                  90                

tac aac tac gga acg gcc caa gac ctc aag aac cta gcc aat gct ttg        384
Tyr Asn Tyr Gly Thr Ala Gln Asp Leu Lys Asn Leu Ala Asn Ala Leu           
            95                  100                 105                   

cac gag cgc ggc atg tat ttg atg gtt gat gtg gtt gcc aac cac atg        432
His Glu Arg Gly Met Tyr Leu Met Val Asp Val Val Ala Asn His Met           
        110                 115                 120                       

ggc tat gac gga gcg gga aac acc gtg gac tac agt gtt ttc aac ccc        480
Gly Tyr Asp Gly Ala Gly Asn Thr Val Asp Tyr Ser Val Phe Asn Pro           
    125                 130                 135                           

ttc tcc tcc tcc tcc tac ttt cac cca tac tgc ctc atc tcc aat tac        528
Phe Ser Ser Ser Ser Tyr Phe His Pro Tyr Cys Leu Ile Ser Asn Tyr           
140                 145                 150                 155           

gac aac cag acc aat gtt gaa gac tgc tgg ctg ggc gat acc acc gtt        576
Asp Asn Gln Thr Asn Val Glu Asp Cys Trp Leu Gly Asp Thr Thr Val           
                160                 165                 170               

tcg ctg cca gat ctc gac acg aca agc aca gcc gtg cgg aac atc tgg        624
Ser Leu Pro Asp Leu Asp Thr Thr Ser Thr Ala Val Arg Asn Ile Trp           
            175                 180                 185                   

tac gac tgg gtg gca gat ttg gtc gcc aac tat tct atc gac ggt ctg        672
Tyr Asp Trp Val Ala Asp Leu Val Ala Asn Tyr Ser Ile Asp Gly Leu           
        190                 195                 200                       

cgt gtc gac act gta aaa cac gtc gaa aaa gac ttt tgg ccc ggc tat        720
Arg Val Asp Thr Val Lys His Val Glu Lys Asp Phe Trp Pro Gly Tyr           
    205                 210                 215                           

aac agc gca gca ggc gtc tac tgt gtc ggc gag gtc tac tca ggc gat        768
Asn Ser Ala Ala Gly Val Tyr Cys Val Gly Glu Val Tyr Ser Gly Asp           
220                 225                 230                 235           

cct gca tac aca tgc ccg tac cag aac tac atg gac ggt gtg ctc aac        816
Pro Ala Tyr Thr Cys Pro Tyr Gln Asn Tyr Met Asp Gly Val Leu Asn           
                240                 245                 250               

tat cca att tac tac cag ctt ctc tat gcg ttt gag tcg tcc agc ggc        864
Tyr Pro Ile Tyr Tyr Gln Leu Leu Tyr Ala Phe Glu Ser Ser Ser Gly           
            255                 260                 265                   

agc atc agc gat ctc tac aac atg atc agc tcc gtt gcc tcc agc tgc        912
Ser Ile Ser Asp Leu Tyr Asn Met Ile Ser Ser Val Ala Ser Ser Cys           
        270                 275                 280                       

aag gat ccc aca ctc ctg ggg aac ttc atc gag aac cac gat aac ccc        960
Lys Asp Pro Thr Leu Leu Gly Asn Phe Ile Glu Asn His Asp Asn Pro           
    285                 290                 295                           

cgc ttc gct tcc tac acg agc gac tac tcg cag gct aag aac gtg atc       1008
Arg Phe Ala Ser Tyr Thr Ser Asp Tyr Ser Gln Ala Lys Asn Val Ile           
300                 305                 310                 315           

acc ttc atc ttc ctg agc gac ggt atc ccc atc gtc tac gcc gga cag       1056
Thr Phe Ile Phe Leu Ser Asp Gly Ile Pro Ile Val Tyr Ala Gly Gln           
                320                 325                 330               

gaa cag cac tac agc gga ggc agc gac cca gct aac cgc gag gcc acc       1104
Glu Gln His Tyr Ser Gly Gly Ser Asp Pro Ala Asn Arg Glu Ala Thr           
            335                 340                 345                   

tgg ctg tcc gga tac tcc acc agc gct acg ctg tac acc tgg atc gcc       1152
Trp Leu Ser Gly Tyr Ser Thr Ser Ala Thr Leu Tyr Thr Trp Ile Ala           
        350                 355                 360                       

acc aca aac cag atc cgc agc ctg gcg atc tcc aag gac gcg gga tac       1200
Thr Thr Asn Gln Ile Arg Ser Leu Ala Ile Ser Lys Asp Ala Gly Tyr           
    365                 370                 375                           

gtg cag gcc aag aac aac ccc ttc tac tcc gac tcc aac acc atc gcc       1248
Val Gln Ala Lys Asn Asn Pro Phe Tyr Ser Asp Ser Asn Thr Ile Ala           
380                 385                 390                 395           

atg cgc aag ggc acg aca gcc ggc gcg caa gtc atc acc gtc ctc agc       1296
Met Arg Lys Gly Thr Thr Ala Gly Ala Gln Val Ile Thr Val Leu Ser           
                400                 405                 410               

aac aag ggc gcc tcc ggc agc tcc tac act ctc tct ttg agt ggt acc       1344
Asn Lys Gly Ala Ser Gly Ser Ser Tyr Thr Leu Ser Leu Ser Gly Thr           
            415                 420                 425                   

ggc tac tcc gcc ggc gtg acc ctg gtc gag acg tac acc tgc acc acg       1392
Gly Tyr Ser Ala Gly Val Thr Leu Val Glu Thr Tyr Thr Cys Thr Thr           
        430                 435                 440                       

gtg act gta gac tcg agc ggc aac ctg ccc gtc cca atg aca tcc ggc       1440
Val Thr Val Asp Ser Ser Gly Asn Leu Pro Val Pro Met Thr Ser Gly           
    445                 450                 455                           

ttg ccg cga gtg ttt gtc ccg tcg tcc tgg gtg aat ggg agc gcg ctt       1488
Leu Pro Arg Val Phe Val Pro Ser Ser Trp Val Asn Gly Ser Ala Leu           
460                 465                 470                 475           

tgc aac acg acg ggg acg ggg ggc agc act ggc act act acc gct tcc       1536
Cys Asn Thr Thr Gly Thr Gly Gly Ser Thr Gly Thr Thr Thr Ala Ser           
                480                 485                 490               

gag acc gga gga tca tcg cca acc tcg aca gca tgc gcg tcc gtc ccc       1584
Glu Thr Gly Gly Ser Ser Pro Thr Ser Thr Ala Cys Ala Ser Val Pro           
            495                 500                 505                   

gta act ttt aac gag aag gtt acg acc gtc gtc ggg gag acg atc aag       1632
Val Thr Phe Asn Glu Lys Val Thr Thr Val Val Gly Glu Thr Ile Lys           
        510                 515                 520                       

ata tcc ggc agc gtg gcc gcc ctc ggc gac tgg gcc acg ggc agc gcg       1680
Ile Ser Gly Ser Val Ala Ala Leu Gly Asp Trp Ala Thr Gly Ser Ala           
    525                 530                 535                           

gtg gcc ctg agc gcc gcg agc tac acg tcc agc aac ccg cag tgg gac       1728
Val Ala Leu Ser Ala Ala Ser Tyr Thr Ser Ser Asn Pro Gln Trp Asp           
540                 545                 550                 555           

gtg acc atc agc ttt gcg ccg ggc acc gtg atc gag tac aag tac atc       1776
Val Thr Ile Ser Phe Ala Pro Gly Thr Val Ile Glu Tyr Lys Tyr Ile           
                560                 565                 570               

aac gtg gcg agc agc ggg gcc gtg acc tgg gag gcc gac ccg aac cac       1824
Asn Val Ala Ser Ser Gly Ala Val Thr Trp Glu Ala Asp Pro Asn His           
            575                 580                 585                   

acg tac acg gtc ccg gcg tcc tgc gcc acg gcc gcc gtc gtg tct gac       1872
Thr Tyr Thr Val Pro Ala Ser Cys Ala Thr Ala Ala Val Val Ser Asp           
        590                 595                 600                       

acg tgg cag acg tga                                                   1887
Thr Trp Gln Thr                                                           
    605                                                                   


<210>  6
<211>  628
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Arg Leu Ser Thr Ser Ser Leu Phe Leu Ser Val Ser Leu Leu Gly 
    -20                 -15                 -10                 


Lys Leu Ala Leu Gly Leu Thr Pro Ala Glu Trp Arg Ser Gln Ser Ile 
-5              -1  1               5                   10      


Tyr Phe Leu Leu Thr Asp Arg Phe Gly Arg Thr Asp Asn Ser Thr Thr 
            15                  20                  25          


Ala Ala Cys Asp Thr Ser Asp Arg Val Tyr Cys Gly Gly Ser Trp Gln 
        30                  35                  40              


Gly Ile Ile Asn Gln Leu Asp Tyr Ile Gln Gly Met Gly Phe Thr Ala 
    45                  50                  55                  


Ile Trp Ile Thr Pro Val Thr Gly Gln Phe Tyr Glu Asn Thr Gly Asp 
60                  65                  70                  75  


Gly Thr Ser Tyr His Gly Tyr Trp Gln Gln Asp Ile Tyr Asp Leu Asn 
                80                  85                  90      


Tyr Asn Tyr Gly Thr Ala Gln Asp Leu Lys Asn Leu Ala Asn Ala Leu 
            95                  100                 105         


His Glu Arg Gly Met Tyr Leu Met Val Asp Val Val Ala Asn His Met 
        110                 115                 120             


Gly Tyr Asp Gly Ala Gly Asn Thr Val Asp Tyr Ser Val Phe Asn Pro 
    125                 130                 135                 


Phe Ser Ser Ser Ser Tyr Phe His Pro Tyr Cys Leu Ile Ser Asn Tyr 
140                 145                 150                 155 


Asp Asn Gln Thr Asn Val Glu Asp Cys Trp Leu Gly Asp Thr Thr Val 
                160                 165                 170     


Ser Leu Pro Asp Leu Asp Thr Thr Ser Thr Ala Val Arg Asn Ile Trp 
            175                 180                 185         


Tyr Asp Trp Val Ala Asp Leu Val Ala Asn Tyr Ser Ile Asp Gly Leu 
        190                 195                 200             


Arg Val Asp Thr Val Lys His Val Glu Lys Asp Phe Trp Pro Gly Tyr 
    205                 210                 215                 


Asn Ser Ala Ala Gly Val Tyr Cys Val Gly Glu Val Tyr Ser Gly Asp 
220                 225                 230                 235 


Pro Ala Tyr Thr Cys Pro Tyr Gln Asn Tyr Met Asp Gly Val Leu Asn 
                240                 245                 250     


Tyr Pro Ile Tyr Tyr Gln Leu Leu Tyr Ala Phe Glu Ser Ser Ser Gly 
            255                 260                 265         


Ser Ile Ser Asp Leu Tyr Asn Met Ile Ser Ser Val Ala Ser Ser Cys 
        270                 275                 280             


Lys Asp Pro Thr Leu Leu Gly Asn Phe Ile Glu Asn His Asp Asn Pro 
    285                 290                 295                 


Arg Phe Ala Ser Tyr Thr Ser Asp Tyr Ser Gln Ala Lys Asn Val Ile 
300                 305                 310                 315 


Thr Phe Ile Phe Leu Ser Asp Gly Ile Pro Ile Val Tyr Ala Gly Gln 
                320                 325                 330     


Glu Gln His Tyr Ser Gly Gly Ser Asp Pro Ala Asn Arg Glu Ala Thr 
            335                 340                 345         


Trp Leu Ser Gly Tyr Ser Thr Ser Ala Thr Leu Tyr Thr Trp Ile Ala 
        350                 355                 360             


Thr Thr Asn Gln Ile Arg Ser Leu Ala Ile Ser Lys Asp Ala Gly Tyr 
    365                 370                 375                 


Val Gln Ala Lys Asn Asn Pro Phe Tyr Ser Asp Ser Asn Thr Ile Ala 
380                 385                 390                 395 


Met Arg Lys Gly Thr Thr Ala Gly Ala Gln Val Ile Thr Val Leu Ser 
                400                 405                 410     


Asn Lys Gly Ala Ser Gly Ser Ser Tyr Thr Leu Ser Leu Ser Gly Thr 
            415                 420                 425         


Gly Tyr Ser Ala Gly Val Thr Leu Val Glu Thr Tyr Thr Cys Thr Thr 
        430                 435                 440             


Val Thr Val Asp Ser Ser Gly Asn Leu Pro Val Pro Met Thr Ser Gly 
    445                 450                 455                 


Leu Pro Arg Val Phe Val Pro Ser Ser Trp Val Asn Gly Ser Ala Leu 
460                 465                 470                 475 


Cys Asn Thr Thr Gly Thr Gly Gly Ser Thr Gly Thr Thr Thr Ala Ser 
                480                 485                 490     


Glu Thr Gly Gly Ser Ser Pro Thr Ser Thr Ala Cys Ala Ser Val Pro 
            495                 500                 505         


Val Thr Phe Asn Glu Lys Val Thr Thr Val Val Gly Glu Thr Ile Lys 
        510                 515                 520             


Ile Ser Gly Ser Val Ala Ala Leu Gly Asp Trp Ala Thr Gly Ser Ala 
    525                 530                 535                 


Val Ala Leu Ser Ala Ala Ser Tyr Thr Ser Ser Asn Pro Gln Trp Asp 
540                 545                 550                 555 


Val Thr Ile Ser Phe Ala Pro Gly Thr Val Ile Glu Tyr Lys Tyr Ile 
                560                 565                 570     


Asn Val Ala Ser Ser Gly Ala Val Thr Trp Glu Ala Asp Pro Asn His 
            575                 580                 585         


Thr Tyr Thr Val Pro Ala Ser Cys Ala Thr Ala Ala Val Val Ser Asp 
        590                 595                 600             


Thr Trp Gln Thr 
    605         


