                         SEQUENCE LISTING

<110>  UNIVERSIDAD DE GRANADA
       SERVICIO ANDALUZ DE SALUD
       
 
<120>  Mtodo de obtencin de datos tiles para el diagnstico 
       diferencial del cncer de pulmn.

<130>  IPR-454-PCT

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asn His Ser Pro Leu Lys Thr Ala Leu Ala Tyr Glu Cys Phe Gln 
1               5                   10                  15      


Asp Gln Asp Asn Ser Thr Leu Ala Leu Pro Ser Asp Gln Lys Met Lys 
            20                  25                  30          


Thr Gly Thr Ser Gly Arg Gln Arg Val Gln Glu Gln Val Met Met Thr 
        35                  40                  45              


Val Lys Arg Gln Lys Ser Lys Ser Ser Gln Ser Ser Thr Leu Ser His 
    50                  55                  60                  


Ser Asn Arg Gly Ser Met Tyr Asp Gly Leu Ala Asp Asn Tyr Asn Tyr 
65                  70                  75                  80  


Gly Thr Thr Ser Arg Ser Ser Tyr Tyr Ser Lys Phe Gln Ala Gly Asn 
                85                  90                  95      


Gly Ser Trp Gly Tyr Pro Ile Tyr Asn Gly Thr Leu Lys Arg Glu Pro 
            100                 105                 110         


Asp Asn Arg Arg Phe Ser Ser Tyr Ser Gln Met Glu Asn Trp Ser Arg 
        115                 120                 125             


His Tyr Pro Arg Gly Ser Cys Asn Thr Thr Gly Ala Gly Ser Asp Ile 
    130                 135                 140                 


Cys Phe Met Gln Lys Ile Lys Ala Ser Arg Ser Glu Pro Asp Leu Tyr 
145                 150                 155                 160 


Cys Asp Pro Arg Gly Thr Leu Arg Lys Gly Thr Leu Gly Ser Lys Gly 
                165                 170                 175     


Gln Lys Thr Thr Gln Asn Arg Tyr Ser Phe Tyr Ser Thr Cys Ser Gly 
            180                 185                 190         


Gln Lys Ala Ile Lys Lys Cys Pro Val Arg Pro Pro Ser Cys Ala Ser 
        195                 200                 205             


Lys Gln Asp Pro Val Tyr Ile Pro Pro Ile Ser Cys Asn Lys Asp Leu 
    210                 215                 220                 


Ser Phe Gly His Ser Arg Ala Ser Ser Lys Ile Cys Ser Glu Asp Ile 
225                 230                 235                 240 


Glu Cys Ser Gly Leu Thr Ile Pro Lys Ala Val Gln Tyr Leu Ser Ser 
                245                 250                 255     


Gln Asp Glu Lys Tyr Gln Ala Ile Gly Ala Tyr Tyr Ile Gln His Thr 
            260                 265                 270         


Cys Phe Gln Asp Glu Ser Ala Lys Gln Gln Val Tyr Gln Leu Gly Gly 
        275                 280                 285             


Ile Cys Lys Leu Val Asp Leu Leu Arg Ser Pro Asn Gln Asn Val Gln 
    290                 295                 300                 


Gln Ala Ala Ala Gly Ala Leu Arg Asn Leu Val Phe Arg Ser Thr Thr 
305                 310                 315                 320 


Asn Lys Leu Glu Thr Arg Arg Gln Asn Gly Ile Arg Glu Ala Val Ser 
                325                 330                 335     


Leu Leu Arg Arg Thr Gly Asn Ala Glu Ile Gln Lys Gln Leu Thr Gly 
            340                 345                 350         


Leu Leu Trp Asn Leu Ser Ser Thr Asp Glu Leu Lys Glu Glu Leu Ile 
        355                 360                 365             


Ala Asp Ala Leu Pro Val Leu Ala Asp Arg Val Ile Ile Pro Phe Ser 
    370                 375                 380                 


Gly Trp Cys Asp Gly Asn Ser Asn Met Ser Arg Glu Val Val Asp Pro 
385                 390                 395                 400 


Glu Val Phe Phe Asn Ala Thr Gly Cys Leu Arg Lys Arg Leu Gly Met 
                405                 410                 415     


Arg Glu Leu Leu Ala Leu Val Pro Gln Arg Ala Thr Ser Ser Arg Val 
            420                 425                 430         


Asn Leu Ser Ser Ala Asp Ala Gly Arg Gln Thr Met Arg Asn Tyr Ser 
        435                 440                 445             


Gly Leu Ile Asp Ser Leu Met Ala Tyr Val Gln Asn Cys Val Ala Ala 
    450                 455                 460                 


Ser Arg Cys Asp Asp Lys Ser Val Glu Asn Cys Met Cys Val Leu His 
465                 470                 475                 480 


Asn Leu Ser Tyr Arg Leu Asp Ala Glu Val Pro Thr Arg Tyr Arg Gln 
                485                 490                 495     


Leu Glu Tyr Asn Ala Arg Asn Ala Tyr Thr Glu Lys Ser Ser Thr Gly 
            500                 505                 510         


Cys Phe Ser Asn Lys Ser Asp Lys Met Met Asn Asn Asn Tyr Asp Cys 
        515                 520                 525             


Pro Leu Pro Glu Glu Glu Thr Asn Pro Lys Gly Ser Gly Trp Leu Tyr 
    530                 535                 540                 


His Ser Asp Ala Ile Arg Thr Tyr Leu Asn Leu Met Gly Lys Ser Lys 
545                 550                 555                 560 


Lys Asp Ala Thr Leu Glu Ala Cys Ala Gly Ala Leu Gln Asn Leu Thr 
                565                 570                 575     


Ala Ser Lys Gly Leu Met Ser Ser Gly Met Ser Gln Leu Ile Gly Leu 
            580                 585                 590         


Lys Glu Lys Gly Leu Pro Gln Ile Ala Arg Leu Leu Gln Ser Gly Asn 
        595                 600                 605             


Ser Asp Val Val Arg Ser Gly Ala Ser Leu Leu Ser Asn Met Ser Arg 
    610                 615                 620                 


His Pro Leu Leu His Arg Val Met Gly Asn Gln Val Phe Pro Glu Val 
625                 630                 635                 640 


Thr Arg Leu Leu Thr Ser His Thr Gly Asn Thr Ser Asn Ser Glu Asp 
                645                 650                 655     


Ile Leu Ser Ser Ala Cys Tyr Thr Val Arg Asn Leu Met Ala Ser Gln 
            660                 665                 670         


Pro Gln Leu Ala Lys Gln Tyr Phe Ser Ser Ser Met Leu Asn Asn Ile 
        675                 680                 685             


Ile Asn Leu Cys Arg Ser Ser Ala Ser Pro Lys Ala Ala Glu Ala Ala 
    690                 695                 700                 


Arg Leu Leu Leu Ser Asp Met Trp Ser Ser Lys Glu Leu Gln Gly Val 
705                 710                 715                 720 


Leu Arg Gln Gln Gly Phe Asp Arg Asn Met Leu Gly Thr Leu Ala Gly 
                725                 730                 735     


Ala Asn Ser Leu Arg Asn Phe Thr Ser Arg Phe 
            740                 745         


<210>  2
<211>  5447
<212>  DNA
<213>  Homo sapiens

<400>  2
gggtggtgca gggcaggggt ggtatatcct gtctgacgga gggcgggcct cgccagtgcc       60

agagagggac gaaccagggt ggaagcgcca ggagcagctg cagggagccc tcacgcggac      120

cacgcactct atggccgtag ggagccgctg agagcgagaa gagcacgctc ctgcccgccc      180

gctgcaccgc acctcgcctc gcctctctgc tctcctaggc cccggccgcg cgccacccgc      240

ctcccgccac catgaaccac tcgccgctca agaccgcctt ggcgtacgaa tgcttccagg      300

accaggacaa ctccacgttg gctttgccgt cggaccaaaa gatgaaaaca ggcacgtctg      360

gcaggcagcg cgtgcaggag caggtgatga tgaccgtcaa gcggcagaag tccaagtctt      420

cccagtcgtc caccctgagc cactccaatc gaggttccat gtatgatggc ttggctgaca      480

attacaacta tgggaccacc agcaggagca gctactactc caagttccag gcagggaatg      540

gctcatgggg atatccgatc tacaatggaa ccctcaagcg ggagcctgac aacaggcgct      600

tcagctccta cagccagatg gagaactgga gccggcacta cccccggggc agctgtaaca      660

ccaccggcgc aggcagcgac atctgcttca tgcagaaaat caaggcgagc cgcagtgagc      720

ccgacctcta ctgtgaccca cggggcaccc tgcgcaaggg cacgctgggc agcaagggcc      780

agaagaccac ccagaaccgc tacagctttt acagcacctg cagtggtcag aaggccataa      840

agaagtgccc tgtgcgcccg ccctcttgtg cctccaagca ggaccctgtg tatatcccgc      900

ccatctcctg caacaaggac ctgtcctttg gccactctag ggccagctcc aagatctgca      960

gtgaggacat cgagtgcagt gggctgacca tccccaaggc tgtgcagtac ctgagctccc     1020

aggatgagaa gtaccaggcc attggggcct attacatcca gcatacctgc ttccaggatg     1080

aatctgccaa gcaacaggtc tatcagctgg gaggcatctg caagctggtg gacctcctcc     1140

gcagccccaa ccagaacgtc cagcaggccg cggcaggggc cctgcgcaac ctggtgttca     1200

ggagcaccac caacaagctg gagacccgga ggcagaatgg gatccgcgag gcagtcagcc     1260

tcctgaggag aaccgggaac gccgagatcc agaagcagct gactgggctg ctctggaacc     1320

tgtcttccac tgacgagctg aaggaggaac tcattgccga cgccctgcct gttctggccg     1380

accgcgtcat cattcccttc tctggctggt gcgatggcaa tagcaacatg tcccgggaag     1440

tggtggaccc tgaggtcttc ttcaatgcca caggctgctt gagaaagaga ctgggcatgc     1500

gggagcttct ggctcttgtt ccgcaaaggg ccactagtag cagggtgaac ctgagctcgg     1560

ccgatgcagg ccgccagacc atgcgtaact actcagggct cattgattcc ctcatggcct     1620

atgtccagaa ctgtgtagcg gccagccgct gtgacgacaa gtctgtggaa aactgcatgt     1680

gtgttctgca caacctctcc taccgcctgg acgccgaggt gcccacccgc taccgccagc     1740

tggagtataa cgcccgcaac gcctacaccg agaagtcctc cactggctgc ttcagcaaca     1800

agagcgacaa gatgatgaac aacaactatg actgccccct gcctgaggaa gagaccaacc     1860

ccaagggcag cggctggttg taccattcag atgccatccg cacctacctg aacctcatgg     1920

gcaagagcaa gaaagatgct accctggagg cctgtgctgg tgccctgcag aacctgacag     1980

ccagcaaggg gctgatgtcc agtggcatga gccagttgat tgggctgaag gaaaagggcc     2040

tgccacaaat tgcccgcctc ctgcaatctg gcaactctga tgtggtgcgg tccggagcct     2100

ccctcctgag caacatgtcc cgccaccctc tgctgcacag agtgatgggg aaccaggtgt     2160

tcccggaggt gaccaggctc ctcaccagcc acactggcaa taccagcaac tccgaagaca     2220

tcttgtcctc ggcctgctac actgtgagga acctgatggc ctcgcagcca caactggcca     2280

agcagtactt ctccagcagc atgctcaaca acatcatcaa cctgtgccga agcagtgcct     2340

cacccaaggc cgcagaagct gcccggcttc tcctgtctga catgtggtcc agcaaggaac     2400

tgcagggtgt cctcagacag caaggtttcg ataggaacat gctgggaacc ttagctgggg     2460

ccaacagcct caggaacttc acctcccgat tctaagaaga gactgtccaa gcaagttagg     2520

cttgcaggaa gatatgaccc agctgagaag ccctcaggcc tcgctggatg gggttttctg     2580

tccatcctgt gcagtatttg ggaaagttca caagaaactg agaagaaacc taaaaactgt     2640

ggatagtgga aagattttta gatttttttt ttccttgggg aaactggcag gcaatggggg     2700

ttagggaggt tggggcgggg ggggctttct tgagttaaag gggcttatat gtgatgtcaa     2760

tatttcttcc tctgagaaat ggtatatata tgtgtataat gtaagtgtgt gcatgcatgt     2820

gcgcgtgcat gtgtgtgtgt gtgagtgtct taaagcataa ccacaaactg caaaaagcta     2880

ggtaagctat tttgttgcag ctcataaggt ggtgaaaagg actctcctgt gtttcttact     2940

cataggcaag gacaacatgt gctttttggt gagctgctca taattcctga aatgtgtggt     3000

gccagggcaa gggggccatc actgcagtca ggccctcaga ggagtcctgc aggcttccta     3060

ccagtggtct ccaggggtgc aggagtaact ggggctgggc cagcctcccc acttacaagg     3120

ctgctttcca ggaagggagg tctggtgtat ctcatgggag aatctggggt gtctgtaatg     3180

tcacccctcc agcagcgcca caaggactga ggttgggtag gtgtggggtt ccagaggaca     3240

gcaggacact ctcgcatact ttgccaaatg aggcctgctc agaggagtag gagctgaaag     3300

atggtgcctt ccaccctctt gggctgtgtg cccatcagag caggctcagc ctgcaaaggc     3360

cctgcattca gaggtcttgt aatctacttg ttgcaggaga aagaaggtaa aaaatgattt     3420

ttttaagaaa agctatttta ttgcagctct ttcccaagag ctgttctggg aatggctggt     3480

cttcatattc ccagtggaga ggggaacaag tggggctggg catataccta ttccggcttc     3540

tagtgggatg gagttggggt atagaaatta accaggaaga tgtttccacc aagcctgctg     3600

tgagtcaatt gagggagtgt ttggggtccc aggagacttg gacgggggga gtttgggtag     3660

actaggaaag gaaagtgcca tatcagggta ccggtaccgg caagctcaca tctcagccag     3720

gggccatgcc ccacttcccc tgaccccagc tgtcttgtct ccactctgtg aaacccacag     3780

gggatgtgat aaacagggct attaggggta tcagccacgt cgagccccca gactctgtgc     3840

acttcagacc agcagcagca ggagggctcc cgagggcctt atgagaaaac ctgtgtggac     3900

atcccttggt gtacactaag acagagcaga gcccagcgct cccaagcctt cctccttcca     3960

gcttctacct ccatgctagc attgctggtg ttagagagga attaacttcc tggtctgtgc     4020

ccttctctag aagaatataa gatgctcctc ctcctcaccc cttctcagcc tcctcccaag     4080

tcttcctctt ctgcaccacc cccgagtcca aacccacctc ttgccccagc attcaggctg     4140

gaaaacactg atgtggactc agtatgataa ctgagatggg ggacgccaga catgtgagga     4200

cgctgtcctc cgagaggtgt ccccggctgt tagccagctg tgctgtggtg ctgtgggtct     4260

gtcataccct cccttgcttc tgttcacact gggaggccca ctcctggctc acctctccct     4320

ctcagggacc cacgtgggag cctggatccc tggactgtcc tgggcatagg tttcaggggc     4380

ctcctttgtt gtcatcagaa cccagaggaa ttcttctcct aaaaaatacg tatggcatac     4440

caatctgtgc ggggcagtgt cctaagcact tagactacat cagggaagaa cacagaccac     4500

atccctgtcc tcatgcggct tatgttttct ggaggaaagt ggagacacaa gtccttggct     4560

ttagggctcc cccggctggg ggctgtgcag tccggtcagg gcgggagggg aaatgcaccg     4620

ctgcatgtga accttaccag cccaggcgga tgccccttcc ccttagcact accctggcct     4680

cctgcatccc ctcgcctcat gttcctccca ccttcaaaga atgaagagcc ccatgggccc     4740

agcccctgcc ctgggaacca ggcagccttc cagacctcag gggctgaggc agactattag     4800

ggcagggctg actttggtga cactgcccat tccctctcag gccagctcag gtcacccggg     4860

cctctgaccc aggcctgtca ctttgagagg ggcaaaactg agaggggctt ttcctagaga     4920

aagagaacaa ggagcttgcc aggcttcatg tagccgacac acgtctcagg attttaagtc     4980

cacattggcc tcacactacc agggccaatg cccaaaataa ggagttccaa tttggggcca     5040

aatgaggaag gacacagact ctgccctggg atctcctgtg ctagcggcca atgacaaatc     5100

cagtcattgg ccaccagcca cctctgcagt ggggaccaca ctagcagccc tgactccaca     5160

ctcctcctgg ggacccaaga ggcagtgttg ctgtctgcat gtccaccttg gaatctggct     5220

gaactggctg gcaggaccaa gactgcggct ggggtgggca gggaagggaa gccgggggct     5280

gctgtgaggg atcttggagc ttccctgtag cccaccttcc ccttgcttca tgtttgtaga     5340

ggaaccttgt gccggccagg cccagtttcc ttgtgtgata cactaatgta tttgcttttt     5400

ttggaaatag agaaaatcaa taaattgcta gtgtttcttt gaacttt                   5447


<210>  3
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Thr Thr Thr Phe Leu Gln Thr Ser Ser Ser Thr Phe Gly Gly Gly 
1               5                   10                  15      


Ser Thr Arg Gly Gly Ser Leu Leu Ala Gly Gly Gly Gly Phe Gly Gly 
            20                  25                  30          


Gly Ser Leu Ser Gly Gly Gly Gly Ser Arg Ser Ile Ser Ala Ser Ser 
        35                  40                  45              


Ala Arg Phe Val Ser Ser Gly Ser Gly Gly Gly Tyr Gly Gly Gly Met 
    50                  55                  60                  


Arg Val Cys Gly Phe Gly Gly Gly Ala Gly Ser Val Phe Gly Gly Gly 
65                  70                  75                  80  


Phe Gly Gly Gly Val Gly Gly Gly Phe Gly Gly Gly Phe Gly Gly Gly 
                85                  90                  95      


Asp Gly Gly Leu Leu Ser Gly Asn Glu Lys Ile Thr Met Gln Asn Leu 
            100                 105                 110         


Asn Asp Arg Leu Ala Ser Tyr Leu Asp Lys Val Arg Ala Leu Glu Glu 
        115                 120                 125             


Ala Asn Ala Asp Leu Glu Val Lys Ile His Asp Trp Tyr Gln Lys Gln 
    130                 135                 140                 


Thr Pro Thr Ser Pro Glu Cys Asp Tyr Ser Gln Tyr Phe Lys Thr Ile 
145                 150                 155                 160 


Glu Glu Leu Arg Asp Lys Ile Met Ala Thr Thr Ile Asp Asn Ser Arg 
                165                 170                 175     


Val Ile Leu Glu Ile Asp Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg 
            180                 185                 190         


Leu Lys Tyr Glu Asn Glu Leu Ala Leu Arg Gln Gly Val Glu Ala Asp 
        195                 200                 205             


Ile Asn Gly Leu Arg Arg Val Leu Asp Glu Leu Thr Leu Ala Arg Thr 
    210                 215                 220                 


Asp Leu Glu Met Gln Ile Glu Gly Leu Asn Glu Glu Leu Ala Tyr Leu 
225                 230                 235                 240 


Lys Lys Asn His Glu Glu Glu Met Lys Glu Phe Ser Ser Gln Leu Ala 
                245                 250                 255     


Gly Gln Val Asn Val Glu Met Asp Ala Ala Pro Gly Val Asp Leu Thr 
            260                 265                 270         


Arg Val Leu Ala Glu Met Arg Glu Gln Tyr Glu Ala Met Ala Glu Lys 
        275                 280                 285             


Asn Arg Arg Asp Val Glu Ala Trp Phe Phe Ser Lys Thr Glu Glu Leu 
    290                 295                 300                 


Asn Lys Glu Val Ala Ser Asn Thr Glu Met Ile Gln Thr Ser Lys Thr 
305                 310                 315                 320 


Glu Ile Thr Asp Leu Arg Arg Thr Met Gln Glu Leu Glu Ile Glu Leu 
                325                 330                 335     


Gln Ser Gln Leu Ser Met Lys Ala Gly Leu Glu Asn Ser Leu Ala Glu 
            340                 345                 350         


Thr Glu Cys Arg Tyr Ala Thr Gln Leu Gln Gln Ile Gln Gly Leu Ile 
        355                 360                 365             


Gly Gly Leu Glu Ala Gln Leu Ser Glu Leu Arg Cys Glu Met Glu Ala 
    370                 375                 380                 


Gln Asn Gln Glu Tyr Lys Met Leu Leu Asp Ile Lys Thr Arg Leu Glu 
385                 390                 395                 400 


Gln Glu Ile Ala Thr Tyr Arg Ser Leu Leu Glu Gly Gln Asp Ala Lys 
                405                 410                 415     


Met Ala Gly Ile Gly Ile Arg Glu Ala Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Ser Ser Asn Phe His Ile Asn Val Glu Glu Ser Val Asp Gly Gln Val 
        435                 440                 445             


Val Ser Ser His Lys Arg Glu Ile 
    450                 455     


<210>  4
<211>  1861
<212>  DNA
<213>  Homo sapiens

<400>  4
cactcaaggt gtgcaggcag ctgtgtttgt caggaaggca gaaggagttg gctttgcttt       60

aggggaggag acgaggtccc acaacaccct ctgaagggta tataaggagc cccagcgtgc      120

agcctggcct ggtacctcct gccagcatct cttgggtttg ctgagaactc acgggctcca      180

gctacctggc catgaccacc acatttctgc aaacttcttc ctccaccttt gggggtggct      240

caacccgagg gggttccctc ctggctgggg gaggtggctt tggtgggggg agtctctctg      300

ggggaggtgg aagccgaagt atctcagctt cttctgctag gtttgtctct tcagggtcag      360

gaggaggata tgggggtggc atgagggtct gtggctttgg tggaggggct ggtagtgttt      420

tcggtggagg ctttggaggg ggcgttggtg ggggttttgg tggtggcttt ggtggtggcg      480

atggtggtct cctctctggc aatgagaaaa ttaccatgca gaacctcaat gaccgcctgg      540

cctcctacct ggacaaggta cgtgccctgg aggaggccaa tgctgacctg gaggtgaaga      600

tccatgactg gtaccagaag cagaccccaa ccagcccaga atgcgactac agccaatact      660

tcaagaccat tgaagagctc cgggacaaga tcatggccac caccatcgac aactcccggg      720

tcatcctgga gatcgacaat gccaggctgg ctgcggacga cttcaggctc aagtatgaga      780

atgagctggc cctgcgccag ggcgttgagg ctgacatcaa cggcttgcgc cgagtcctgg      840

atgagctgac cctggccagg actgacctgg agatgcagat cgagggcctg aatgaggagc      900

tagcctacct gaagaagaac cacgaagagg agatgaagga gttcagcagc cagctggccg      960

gccaggtcaa tgtggagatg gacgcagcac cgggtgtgga cctgacccgt gtgctggcag     1020

agatgaggga gcagtacgag gccatggcgg agaagaaccg ccgggatgtc gaggcctggt     1080

tcttcagcaa gactgaggag ctgaacaaag aggtggcctc caacacagaa atgatccaga     1140

ccagcaagac ggagatcaca gacctgagac gcacgatgca ggagctggag atcgagctgc     1200

agtcccagct cagcatgaaa gctgggctgg agaactcact ggccgagaca gagtgccgct     1260

atgccacgca gctgcagcag atccaggggc tcattggtgg cctggaggcc cagctgagtg     1320

agctccgatg cgagatggag gctcagaacc aggagtacaa gatgctgctt gacataaaga     1380

cacggctgga gcaggagatc gctacttacc gcagcctgct cgagggccag gatgccaaga     1440

tggctggcat tggcatcagg gaagcctctt caggaggtgg tggtagcagc agcaatttcc     1500

acatcaatgt agaagagtca gtggatggac aggtggtttc ttcccacaag agagaaatct     1560

aagtgtctat tgcaggagaa acgtcccttg ccactcccca ctctcatcag gccaagtgga     1620

ggactggcca gagggcctgc acatgcaaac tccagtccct gccttcagag agctgaaaag     1680

ggtccctcgg tcttttattt cagggctttg catgcgctct attccccctc tgcctctccc     1740

caccttcttt ggagcaagga gatgcagctg tattgtgtaa caagctcatt tgtacagtgt     1800

ctgttcatgt aataaagaat tacttttcct tttgcaaata aaaaaaaaaa aaaaaaaaaa     1860

a                                                                     1861


<210>  5
<211>  999
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Met Gly Leu Phe Pro Arg Thr Thr Gly Ala Leu Ala Ile Phe Val 
1               5                   10                  15      


Val Val Ile Leu Val His Gly Glu Leu Arg Ile Glu Thr Lys Gly Gln 
            20                  25                  30          


Tyr Asp Glu Glu Glu Met Thr Met Gln Gln Ala Lys Arg Arg Gln Lys 
        35                  40                  45              


Arg Glu Trp Val Lys Phe Ala Lys Pro Cys Arg Glu Gly Glu Asp Asn 
    50                  55                  60                  


Ser Lys Arg Asn Pro Ile Ala Lys Ile Thr Ser Asp Tyr Gln Ala Thr 
65                  70                  75                  80  


Gln Lys Ile Thr Tyr Arg Ile Ser Gly Val Gly Ile Asp Gln Pro Pro 
                85                  90                  95      


Phe Gly Ile Phe Val Val Asp Lys Asn Thr Gly Asp Ile Asn Ile Thr 
            100                 105                 110         


Ala Ile Val Asp Arg Glu Glu Thr Pro Ser Phe Leu Ile Thr Cys Arg 
        115                 120                 125             


Ala Leu Asn Ala Gln Gly Leu Asp Val Glu Lys Pro Leu Ile Leu Thr 
    130                 135                 140                 


Val Lys Ile Leu Asp Ile Asn Asp Asn Pro Pro Val Phe Ser Gln Gln 
145                 150                 155                 160 


Ile Phe Met Gly Glu Ile Glu Glu Asn Ser Ala Ser Asn Ser Leu Val 
                165                 170                 175     


Met Ile Leu Asn Ala Thr Asp Ala Asp Glu Pro Asn His Leu Asn Ser 
            180                 185                 190         


Lys Ile Ala Phe Lys Ile Val Ser Gln Glu Pro Ala Gly Thr Pro Met 
        195                 200                 205             


Phe Leu Leu Ser Arg Asn Thr Gly Glu Val Arg Thr Leu Thr Asn Ser 
    210                 215                 220                 


Leu Asp Arg Glu Gln Ala Ser Ser Tyr Arg Leu Val Val Ser Gly Ala 
225                 230                 235                 240 


Asp Lys Asp Gly Glu Gly Leu Ser Thr Gln Cys Glu Cys Asn Ile Lys 
                245                 250                 255     


Val Lys Asp Val Asn Asp Asn Phe Pro Met Phe Arg Asp Ser Gln Tyr 
            260                 265                 270         


Ser Ala Arg Ile Glu Glu Asn Ile Leu Ser Ser Glu Leu Leu Arg Phe 
        275                 280                 285             


Gln Val Thr Asp Leu Asp Glu Glu Tyr Thr Asp Asn Trp Leu Ala Val 
    290                 295                 300                 


Tyr Phe Phe Thr Ser Gly Asn Glu Gly Asn Trp Phe Glu Ile Gln Thr 
305                 310                 315                 320 


Asp Pro Arg Thr Asn Glu Gly Ile Leu Lys Val Val Lys Ala Leu Asp 
                325                 330                 335     


Tyr Glu Gln Leu Gln Ser Val Lys Leu Ser Ile Ala Val Lys Asn Lys 
            340                 345                 350         


Ala Glu Phe His Gln Ser Val Ile Ser Arg Tyr Arg Val Gln Ser Thr 
        355                 360                 365             


Pro Val Thr Ile Gln Val Ile Asn Val Arg Glu Gly Ile Ala Phe Arg 
    370                 375                 380                 


Pro Ala Ser Lys Thr Phe Thr Val Gln Lys Gly Ile Ser Ser Lys Lys 
385                 390                 395                 400 


Leu Val Asp Tyr Ile Leu Gly Thr Tyr Gln Ala Ile Asp Glu Asp Thr 
                405                 410                 415     


Asn Lys Ala Ala Ser Asn Val Lys Tyr Val Met Gly Arg Asn Asp Gly 
            420                 425                 430         


Gly Tyr Leu Met Ile Asp Ser Lys Thr Ala Glu Ile Lys Phe Val Lys 
        435                 440                 445             


Asn Met Asn Arg Asp Ser Thr Phe Ile Val Asn Lys Thr Ile Thr Ala 
    450                 455                 460                 


Glu Val Leu Ala Ile Asp Glu Tyr Thr Gly Lys Thr Ser Thr Gly Thr 
465                 470                 475                 480 


Val Tyr Val Arg Val Pro Asp Phe Asn Asp Asn Cys Pro Thr Ala Val 
                485                 490                 495     


Leu Glu Lys Asp Ala Val Cys Ser Ser Ser Pro Ser Val Val Val Ser 
            500                 505                 510         


Ala Arg Thr Leu Asn Asn Arg Tyr Thr Gly Pro Tyr Thr Phe Ala Leu 
        515                 520                 525             


Glu Asp Gln Pro Val Lys Leu Pro Ala Val Trp Ser Ile Thr Thr Leu 
    530                 535                 540                 


Asn Ala Thr Ser Ala Leu Leu Arg Ala Gln Glu Gln Ile Pro Pro Gly 
545                 550                 555                 560 


Val Tyr His Ile Ser Leu Val Leu Thr Asp Ser Gln Asn Asn Arg Cys 
                565                 570                 575     


Glu Met Pro Arg Ser Leu Thr Leu Glu Val Cys Gln Cys Asp Asn Arg 
            580                 585                 590         


Gly Ile Cys Gly Thr Ser Tyr Pro Thr Thr Ser Pro Gly Thr Arg Tyr 
        595                 600                 605             


Gly Arg Pro His Ser Gly Arg Leu Gly Pro Ala Ala Ile Gly Leu Leu 
    610                 615                 620                 


Leu Leu Gly Leu Leu Leu Leu Leu Leu Ala Pro Leu Leu Leu Leu Thr 
625                 630                 635                 640 


Cys Asp Cys Gly Ala Gly Ser Thr Gly Gly Val Thr Gly Gly Phe Ile 
                645                 650                 655     


Pro Val Pro Asp Gly Ser Glu Gly Thr Ile His Gln Trp Gly Ile Glu 
            660                 665                 670         


Gly Ala His Pro Glu Asp Lys Glu Ile Thr Asn Ile Cys Val Pro Pro 
        675                 680                 685             


Val Thr Ala Asn Gly Ala Asp Phe Met Glu Ser Ser Glu Val Cys Thr 
    690                 695                 700                 


Asn Thr Tyr Ala Arg Gly Thr Ala Val Glu Gly Thr Ser Gly Met Glu 
705                 710                 715                 720 


Met Thr Thr Lys Leu Gly Ala Ala Thr Glu Ser Gly Gly Ala Ala Gly 
                725                 730                 735     


Phe Ala Thr Gly Thr Val Ser Gly Ala Ala Ser Gly Phe Gly Ala Ala 
            740                 745                 750         


Thr Gly Val Gly Ile Cys Ser Ser Gly Gln Ser Gly Thr Met Arg Thr 
        755                 760                 765             


Arg His Ser Thr Gly Gly Thr Asn Lys Asp Tyr Ala Asp Gly Ala Ile 
    770                 775                 780                 


Ser Met Asn Phe Leu Asp Ser Tyr Phe Ser Gln Lys Ala Phe Ala Cys 
785                 790                 795                 800 


Ala Glu Glu Asp Asp Gly Gln Glu Ala Asn Asp Cys Leu Leu Ile Tyr 
                805                 810                 815     


Asp Asn Glu Gly Ala Asp Ala Thr Gly Ser Pro Val Gly Ser Val Gly 
            820                 825                 830         


Cys Cys Ser Phe Ile Ala Asp Asp Leu Asp Asp Ser Phe Leu Asp Ser 
        835                 840                 845             


Leu Gly Pro Lys Phe Lys Lys Leu Ala Glu Ile Ser Leu Gly Val Asp 
    850                 855                 860                 


Gly Glu Gly Lys Glu Val Gln Pro Pro Ser Lys Asp Ser Gly Tyr Gly 
865                 870                 875                 880 


Ile Glu Ser Cys Gly His Pro Ile Glu Val Gln Gln Thr Gly Phe Val 
                885                 890                 895     


Lys Cys Gln Thr Leu Ser Gly Ser Gln Gly Ala Ser Ala Leu Ser Thr 
            900                 905                 910         


Ser Gly Ser Val Gln Pro Ala Val Ser Ile Pro Asp Pro Leu Gln His 
        915                 920                 925             


Gly Asn Tyr Leu Val Thr Glu Thr Tyr Ser Ala Ser Gly Ser Leu Val 
    930                 935                 940                 


Gln Pro Ser Thr Ala Gly Phe Asp Pro Leu Leu Thr Gln Asn Val Ile 
945                 950                 955                 960 


Val Thr Glu Arg Val Ile Cys Pro Ile Ser Ser Val Pro Gly Asn Leu 
                965                 970                 975     


Ala Gly Pro Thr Gln Leu Arg Gly Ser His Thr Met Leu Cys Thr Glu 
            980                 985                 990         


Asp Pro Cys Ser Arg Leu Ile 
        995                 


<210>  6
<211>  5561
<212>  DNA
<213>  Homo sapiens

<400>  6
aaagcagcag agacgctgca gagggctttt cttagacatc aactgcagac ggctggcagg       60

atagaagcag cggctcactt ggactttttc accagggaaa tcagagacaa tgatggggct      120

cttccccaga actacagggg ctctggccat cttcgtggtg gtcatattgg ttcatggaga      180

attgcgaata gagactaaag gtcaatatga tgaagaagag atgactatgc aacaagctaa      240

aagaaggcaa aaacgtgaat gggtgaaatt tgccaaaccc tgcagagaag gagaagataa      300

ctcaaaaaga aacccaattg ccaagattac ttcagattac caagcaaccc agaaaatcac      360

ctaccgaatc tctggagtgg gaatcgatca gccgcctttt ggaatctttg ttgttgacaa      420

aaacactgga gatattaaca taacagctat agtcgaccgg gaggaaactc caagcttcct      480

gatcacatgt cgggctctaa atgcccaagg actagatgta gagaaaccac ttatactaac      540

ggttaaaatt ttggatatta atgataatcc tccagtattt tcacaacaaa ttttcatggg      600

tgaaattgaa gaaaatagtg cctcaaactc actggtgatg atactaaatg ccacagatgc      660

agatgaacca aaccacttga attctaaaat tgccttcaaa attgtctctc aggaaccagc      720

aggcacaccc atgttcctcc taagcagaaa cactggggaa gtccgtactt tgaccaattc      780

tcttgaccga gagcaagcta gcagctatcg tctggttgtg agtggtgcag acaaagatgg      840

agaaggacta tcaactcaat gtgaatgtaa tattaaagtg aaagatgtca acgataactt      900

cccaatgttt agagactctc agtattcagc acgtattgaa gaaaatattt taagttctga      960

attacttcga tttcaagtaa cagatttgga tgaagagtac acagataatt ggcttgcagt     1020

atatttcttt acctctggga atgaaggaaa ttggtttgaa atacaaactg atcctagaac     1080

taatgaaggc atcctgaaag tggtgaaggc tctagattat gaacaactac aaagcgtgaa     1140

acttagtatt gctgtcaaaa acaaagctga atttcaccaa tcagttatct ctcgataccg     1200

agttcagtca accccagtca caattcaggt aataaatgta agagaaggaa ttgcattccg     1260

tcctgcttcc aagacattta ctgtgcaaaa aggcataagt agcaaaaaat tggtggatta     1320

tatcctggga acatatcaag ccatcgatga ggacactaac aaagctgcct caaatgtcaa     1380

atatgtcatg ggacgtaacg atggtggata cctaatgatt gattcaaaaa ctgctgaaat     1440

caaatttgtc aaaaatatga accgagattc tactttcata gttaacaaaa caatcacagc     1500

tgaggttctg gccatagatg aatacacggg taaaacttct acaggcacgg tatatgttag     1560

agtacccgat ttcaatgaca attgtccaac agctgtcctc gaaaaagatg cagtttgcag     1620

ttcttcacct tccgtggttg tctccgctag aacactgaat aatagataca ctggccccta     1680

tacatttgca ctggaagatc aacctgtaaa gttgcctgcc gtatggagta tcacaaccct     1740

caatgctacc tcggccctcc tcagagccca ggaacagata cctcctggag tataccacat     1800

ctccctggta cttacagaca gtcagaacaa tcggtgtgag atgccacgca gcttgacact     1860

ggaagtctgt cagtgtgaca acaggggcat ctgtggaact tcttacccaa ccacaagccc     1920

tgggaccagg tatggcaggc cgcactcagg gaggctgggg cctgccgcca tcggcctgct     1980

gctccttggt ctcctgctgc tgctgttggc cccccttctg ctgttgacct gtgactgtgg     2040

ggcaggttct actgggggag tgacaggtgg ttttatccca gttcctgatg gctcagaagg     2100

aacaattcat cagtggggaa ttgaaggagc ccatcctgaa gacaaggaaa tcacaaatat     2160

ttgtgtgcct cctgtaacag ccaatggagc cgatttcatg gaaagttctg aagtttgtac     2220

aaatacgtat gccagaggca cagcggtgga aggcacttca ggaatggaaa tgaccactaa     2280

gcttggagca gccactgaat ctggaggtgc tgcaggcttt gcaacaggga cagtgtcagg     2340

agctgcttca ggattcggag cagccactgg agttggcatc tgttcctcag ggcagtctgg     2400

aaccatgaga acaaggcatt ccactggagg aaccaataag gactacgctg atggggcgat     2460

aagcatgaat tttctggact cctacttttc tcagaaagca tttgcctgtg cggaggaaga     2520

cgatggccag gaagcaaatg actgcttgtt gatctatgat aatgaaggcg cagatgccac     2580

tggttctcct gtgggctccg tgggttgttg cagttttatt gctgatgacc tggatgacag     2640

cttcttggac tcacttggac ccaaatttaa aaaacttgca gagataagcc ttggtgttga     2700

tggtgaaggc aaagaagttc agccaccctc taaagacagc ggttatggga ttgaatcctg     2760

tggccatccc atagaagtcc agcagacagg atttgttaag tgccagactt tgtcaggaag     2820

tcaaggagct tctgctttgt ccacctctgg gtctgtccag ccagctgttt ccatccctga     2880

ccctctgcag catggtaact atttagtaac ggagacttac tcggcttctg gttccctcgt     2940

gcaaccttcc actgcaggct ttgatccact tctcacacaa aatgtgatag tgacagaaag     3000

ggtgatctgt cccatttcca gtgttcctgg caacctagct ggcccaacgc agctacgagg     3060

gtcacatact atgctctgta cagaggatcc ttgctcccgt ctaatatgac cagaatgagc     3120

tggaatacca cactgaccaa atctggatct ttggactaaa gtattcaaaa tagcatagca     3180

aagctcactg tattgggcta ataatttggc acttattagc ttctctcata aactgatcac     3240

gattataaat taaatgtttg ggttcatacc ccaaaagcaa tatgttgtca ctcctaattc     3300

tcaagtacta ttcaaattgt agtaaatctt aaagtttttc aaaaccctaa aatcatattc     3360

gccaggaaat tttcctaaac attcttaagc ttctattttt cccctgccaa aggaaggtgt     3420

ttatcatttt aaaatgcaat gtgatttagt ggattaagca ggagcgctgg ttcttgtctc     3480

cattgccttt tcttatatca ttgataatga tgtaagaatc acaaggggcc gggcgcggtg     3540

gctcacgcct gtaatcccag cactttggga ggccgaggca ggtggatcat gaggtcagga     3600

gatcgagacc atcctggcta acaaggtgaa accccgtctc tactaaaaat acaaaaaatt     3660

agccgggcgc agtggcgggc gcctgtagtc ccagctactc gggaggctga ggcaggagaa     3720

tggcatgaac ccgggaagcg gagcttgcag tgagccgaga ttgcgccact gcagtccgca     3780

gtccggcctg ggcgacagag cgagactccg tctcaaaaaa aaaaaaaaaa aaagaatcac     3840

aaggtatttg ctaaagcatt ttgagctgct tggaaaaagg gaagtagttg cagtagagtt     3900

tcttccatct tcttggtgct gggaagccat atatgtgtct tttactcaag ctaaggggta     3960

taagcttatg tgttgaattt gctacatcta tatttcacat attctcacaa taagagaatt     4020

ttgaaataga aatatcatag aacatttaag aaagtttagt ataaataata ttttgtgtgt     4080

tttaatccct ttgaagggat ctatccaaag aaaatatttt acactgagct ccttcctaca     4140

cgtctcagta acagatcctg tgttagtctt tgaaaatagc tcatttttta aatgtcagtg     4200

agtagatgta gcatacatat gatgtataat gacgtgtatt atgttaacaa tgtctgcaga     4260

ttttgtagga atacaaaaca tggccttttt tataagcaaa acgggccaat gactagaata     4320

acacataggg caatctgtga atatgtatta taagcagcat tccagaaaag tagttggtga     4380

aataattttc aagtcaaaaa gggatatgga aagggaatta tgagtaacct ctatttttta     4440

agccttgctt ttaaattaaa cagctacagc catttaagcc ttgaggataa taaagcttga     4500

gagtaataat gttaggttag caaaggttta gatgtatcac ttcatgcatg ctaccatgat     4560

agtaatgcag ctcttcgagt catttctggt cattcaagat attcaccctt ttgcccatag     4620

aaagcaccct acctcacctg cttactgaca ttgtcttagc tgatcacaag atcattatca     4680

gcctccatta ttccttactg tatataaaat acagagtttt atattttcct ttcttcgttt     4740

ttcaccatat tcaaaaccta aatttgtttt tgcagatgga atgcaaagta atcaagtgtt     4800

tgtgctttca cctagaaggg tgtggtcctg aaggaaagag gtcccctaaa tatcccccac     4860

cctggtgctc ctccctctcc ctggtaccct gactaccagg aagtcaggtg ctagagcagc     4920

tggagaagtg caggcagcct gtgcttccac agatgggggt gctgctgcaa caaggctttc     4980

aatgtgccca tcttaggtgg gagaagctag atcctgtgca gcagcctggt aagtcctgag     5040

gaggttccat tgctcttcct gctgctgtcc tttgcttctc aacggtggct cgctctacag     5100

tctagagcac atgcagctaa cttgtgcctc tgcttatgca tgagggttaa attaacaacc     5160

ataaccttca tttgaagttc aaaggtgtat tcaggatcct caaagcattt taaccttgcc     5220

gcttaaaacc caatttaccg tgaaatggga attttgctgc attgttaaac tgtagtggaa     5280

accatgctat agtaataaag gttatataag agagaaattg aaattaaatg tgtttttaaa     5340

tttcaaaaaa aaatcaatct ttaggatgac ttaaaaattg atttgccatg taaaatgtat     5400

ctgcattttt tacacaaaac ttgttttaag cataaaattt taaaactgta ctacttgatg     5460

tattatacat tttgaaccat atgtattaaa ccataaacag tataatgttg ttataataaa     5520

acaggcaata aatttataaa taaaagctga aaaaaaaaaa a                         5561


