               SEQUENCE LISTING

<110> BOUMENDIL, Olivier-Georges 

<120> ENZYME HAVING A NMDA RECEPTOR ANTAGONIST ACTIVITY AND/OR AN ANTICHOLINERGIC ACTIVITY

<130> CV-252/PCT

<160> 53

<170> BiSSAP 1.2

<210> 1
<211> 365
<212> PRT
<213> Flavobacterium sp.


<400> 1
Met Gln Thr Arg Arg Val Val Leu Lys Ser Ala Ala Ala Ala Gly Thr 
1               5                   10                  15      
Leu Leu Gly Gly Leu Ala Gly Cys Ala Ser Val Ala Gly Ser Ile Gly 
            20                  25                  30          
Thr Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr Ile Ser Glu 
        35                  40                  45              
Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser Ser Ala Gly 
    50                  55                  60                  
Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Lys Ala Leu Ala 
65                  70                  75                  80  
Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala Gly Val Arg 
                85                  90                  95      
Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp Val Ser Leu 
            100                 105                 110         
Leu Ala Glu Val Ser Arg Ala Ala Asp Val His Ile Val Ala Ala Thr 
        115                 120                 125             
Gly Leu Trp Phe Asp Pro Pro Leu Ser Met Arg Leu Arg Ser Val Glu 
    130                 135                 140                 
Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp 
145                 150                 155                 160 
Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Thr Gly Lys Ala 
                165                 170                 175     
Thr Pro Phe Gln Glu Leu Val Leu Lys Ala Ala Ala Arg Ala Ser Leu 
            180                 185                 190         
Ala Thr Gly Val Pro Val Thr Thr His Thr Ala Ala Ser Gln Arg Asp 
        195                 200                 205             
Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu Ser Pro Ser 
    210                 215                 220                 
Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu Ser Tyr Leu 
225                 230                 235                 240 
Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp His Ile Pro 
                245                 250                 255     
His Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser Ala Leu Leu 
            260                 265                 270         
Gly Ile Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile 
        275                 280                 285             
Asp Gln Gly Tyr Met Lys Gln Ile Leu Val Ser Asn Asp Trp Leu Phe 
    290                 295                 300                 
Gly Phe Ser Ser Tyr Val Thr Asn Ile Met Asp Val Met Asp Arg Val 
305                 310                 315                 320 
Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile Pro Phe Leu 
                325                 330                 335     
Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Gly Ile Thr Val Thr 
            340                 345                 350         
Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
        355                 360                 365 

<210> 2
<211> 336
<212> PRT
<213> Artificial Sequence

<220> 
<223> OPH

<400> 2
Ser Ile Gly Thr Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr 
1               5                   10                  15      
Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          
Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Lys 
        35                  40                  45              
Ala Leu Ala Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala 
    50                  55                  60                  
Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp 
65                  70                  75                  80  
Val Ser Leu Leu Ala Glu Val Ser Arg Ala Ala Asp Val His Ile Val 
                85                  90                  95      
Ala Ala Thr Gly Leu Trp Phe Asp Pro Pro Leu Ser Met Arg Leu Arg 
            100                 105                 110         
Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly 
        115                 120                 125             
Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Thr 
    130                 135                 140                 
Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Lys Ala Ala Ala Arg 
145                 150                 155                 160 
Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Ala Ala Ser 
                165                 170                 175     
Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         
Ser Pro Ser Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu 
        195                 200                 205             
Ser Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp 
    210                 215                 220                 
His Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser 
225                 230                 235                 240 
Ala Leu Leu Gly Ile Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     
Ala Leu Ile Asp Gln Gly Tyr Met Lys Gln Ile Leu Val Ser Asn Asp 
            260                 265                 270         
Trp Leu Phe Gly Phe Ser Ser Tyr Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             
Asp Arg Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile 
    290                 295                 300                 
Pro Phe Leu Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Gly Ile 
305                 310                 315                 320 
Thr Val Thr Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330                 335     



<210> 3
<211> 384
<212> PRT
<213> Agrobacterium radiobacter 


<400> 3
Met Gln Thr Arg Arg Asp Ala Leu Lys Ser Ala Ala Ala Ile Thr Leu 
1               5                   10                  15      
Leu Gly Gly Leu Ala Gly Cys Ala Ser Met Ala Arg Pro Ile Gly Thr 
            20                  25                  30          
Gly Asp Leu Ile Asn Thr Val Arg Gly Pro Ile Pro Val Ser Glu Ala 
        35                  40                  45              
Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser Ser Ala Gly Phe 
    50                  55                  60                  
Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Lys Ala Leu Ala Glu 
65                  70                  75                  80  
Lys Ala Val Arg Gly Leu Arg His Ala Arg Ser Ala Gly Val Gln Thr 
                85                  90                  95      
Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp Val Arg Leu Leu 
            100                 105                 110         
Ala Glu Val Ser Arg Ala Ala Asp Val His Ile Val Ala Ala Thr Gly 
        115                 120                 125             
Leu Trp Phe Asp Pro Pro Leu Ser Met Arg Met Arg Ser Val Glu Glu 
    130                 135                 140                 
Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln His Gly Ile Glu Asp Thr 
145                 150                 155                 160 
Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Thr Gly Lys Ala Thr 
                165                 170                 175     
Pro Phe Gln Glu Leu Val Leu Lys Ala Ala Ala Arg Ala Ser Leu Ala 
            180                 185                 190         
Thr Gly Val Pro Val Thr Thr His Thr Ser Ala Ser Gln Arg Asp Gly 
        195                 200                 205             
Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu Ser Pro Ser Arg 
    210                 215                 220                 
Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu Ser Tyr Leu Thr 
225                 230                 235                 240 
Gly Leu Ala Ala Arg Gly Tyr Leu Val Gly Leu Asp Arg Met Pro Tyr 
                245                 250                 255     
Ser Ala Ile Gly Leu Glu Gly Asn Ala Ser Ala Leu Ala Leu Phe Gly 
            260                 265                 270         
Thr Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp 
        275                 280                 285             
Arg Gly Tyr Lys Asp Arg Ile Leu Val Ser His Asp Trp Leu Phe Gly 
    290                 295                 300                 
Phe Ser Ser Tyr Val Thr Asn Ile Met Asp Val Met Asp Arg Ile Asn 
305                 310                 315                 320 
Pro Asp Gly Met Ala Phe Val Pro Leu Arg Val Ile Pro Phe Leu Arg 
                325                 330                 335     
Glu Lys Gly Val Pro Pro Glu Thr Leu Ala Gly Val Thr Val Ala Asn 
            340                 345                 350         
Pro Ala Arg Phe Leu Ser Pro Thr Val Arg Ala Val Val Thr Arg Ser 
        355                 360                 365             
Glu Thr Ser Arg Pro Ala Ala Pro Ile Pro Arg Gln Asp Thr Glu Arg 
    370                 375                 380                 



<210> 4
<211> 356
<212> PRT
<213> Artificial Sequence

<220> 
<223> OPDA

<400> 4
Pro Ile Gly Thr Gly Asp Leu Ile Asn Thr Val Arg Gly Pro Ile Pro 
1               5                   10                  15      
Val Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          
Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Lys 
        35                  40                  45              
Ala Leu Ala Glu Lys Ala Val Arg Gly Leu Arg His Ala Arg Ser Ala 
    50                  55                  60                  
Gly Val Gln Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp 
65                  70                  75                  80  
Val Arg Leu Leu Ala Glu Val Ser Arg Ala Ala Asp Val His Ile Val 
                85                  90                  95      
Ala Ala Thr Gly Leu Trp Phe Asp Pro Pro Leu Ser Met Arg Met Arg 
            100                 105                 110         
Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln His Gly 
        115                 120                 125             
Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Thr 
    130                 135                 140                 
Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Lys Ala Ala Ala Arg 
145                 150                 155                 160 
Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Ser Ala Ser 
                165                 170                 175     
Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         
Ser Pro Ser Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu 
        195                 200                 205             
Ser Tyr Leu Thr Gly Leu Ala Ala Arg Gly Tyr Leu Val Gly Leu Asp 
    210                 215                 220                 
Arg Met Pro Tyr Ser Ala Ile Gly Leu Glu Gly Asn Ala Ser Ala Leu 
225                 230                 235                 240 
Ala Leu Phe Gly Thr Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     
Ala Leu Ile Asp Arg Gly Tyr Lys Asp Arg Ile Leu Val Ser His Asp 
            260                 265                 270         
Trp Leu Phe Gly Phe Ser Ser Tyr Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             
Asp Arg Ile Asn Pro Asp Gly Met Ala Phe Val Pro Leu Arg Val Ile 
    290                 295                 300                 
Pro Phe Leu Arg Glu Lys Gly Val Pro Pro Glu Thr Leu Ala Gly Val 
305                 310                 315                 320 
Thr Val Ala Asn Pro Ala Arg Phe Leu Ser Pro Thr Val Arg Ala Val 
                325                 330                 335     
Val Thr Arg Ser Glu Thr Ser Arg Pro Ala Ala Pro Ile Pro Arg Gln 
            340                 345                 350         
Asp Thr Glu Arg 
        355     

<210> 5
<211> 292
<212> PRT
<213> Escherichia coli


<400> 5
Met Ser Phe Asp Pro Thr Gly Tyr Thr Leu Ala His Glu His Leu His 
1               5                   10                  15      
Ile Asp Leu Ser Gly Phe Lys Asn Asn Val Asp Cys Arg Leu Asp Gln 
            20                  25                  30          
Tyr Ala Phe Ile Cys Gln Glu Met Asn Asp Leu Met Thr Arg Gly Val 
        35                  40                  45              
Arg Asn Val Ile Glu Met Thr Asn Arg Tyr Met Gly Arg Asn Ala Gln 
    50                  55                  60                  
Phe Met Leu Asp Val Met Arg Glu Thr Gly Ile Asn Val Val Ala Cys 
65                  70                  75                  80  
Thr Gly Tyr Tyr Gln Asp Ala Phe Phe Pro Glu His Val Ala Thr Arg 
                85                  90                  95      
Ser Val Gln Glu Leu Ala Gln Glu Met Val Asp Glu Ile Glu Gln Gly 
            100                 105                 110         
Ile Asp Gly Thr Glu Leu Lys Ala Gly Ile Ile Ala Glu Ile Gly Thr 
        115                 120                 125             
Ser Glu Gly Lys Ile Thr Pro Leu Glu Glu Lys Val Phe Ile Ala Ala 
    130                 135                 140                 
Ala Leu Ala His Asn Gln Thr Gly Arg Pro Ile Ser Thr His Thr Ser 
145                 150                 155                 160 
Phe Ser Thr Met Gly Leu Glu Gln Leu Ala Leu Leu Gln Ala His Gly 
                165                 170                 175     
Val Asp Leu Ser Arg Val Thr Val Gly His Cys Asp Leu Lys Asp Asn 
            180                 185                 190         
Leu Asp Asn Ile Leu Lys Met Ile Asp Leu Gly Ala Tyr Val Gln Phe 
        195                 200                 205             
Asp Thr Ile Gly Lys Asn Ser Tyr Tyr Pro Asp Glu Lys Arg Ile Ala 
    210                 215                 220                 
Met Leu His Ala Leu Arg Asp Arg Gly Leu Leu Asn Arg Val Met Leu 
225                 230                 235                 240 
Ser Met Asp Ile Thr Arg Arg Ser His Leu Lys Ala Asn Gly Gly Tyr 
                245                 250                 255     
Gly Tyr Asp Tyr Leu Leu Thr Thr Phe Ile Pro Gln Leu Arg Gln Ser 
            260                 265                 270         
Gly Phe Ser Gln Ala Asp Val Asp Val Met Leu Arg Glu Asn Pro Ser 
        275                 280                 285             
Gln Phe Phe Gln 
    290         

<210> 6
<211> 326
<212> PRT
<213> Mycobacterium tuberculosis


<400> 6
Met Pro Glu Leu Asn Thr Ala Arg Gly Pro Ile Asp Thr Ala Asp Leu 
1               5                   10                  15      
Gly Val Thr Leu Met His Glu His Val Phe Ile Met Thr Thr Glu Ile 
            20                  25                  30          
Ala Gln Asn Tyr Pro Glu Ala Trp Gly Asp Glu Asp Lys Arg Val Ala 
        35                  40                  45              
Gly Ala Ile Ala Arg Leu Gly Glu Leu Lys Ala Arg Gly Val Asp Thr 
    50                  55                  60                  
Ile Val Asp Leu Thr Val Ile Gly Leu Gly Arg Tyr Ile Pro Arg Ile 
65                  70                  75                  80  
Ala Arg Val Ala Ala Ala Thr Glu Leu Asn Ile Val Val Ala Thr Gly 
                85                  90                  95      
Leu Tyr Thr Tyr Asn Asp Val Pro Phe Tyr Phe His Tyr Leu Gly Pro 
            100                 105                 110         
Gly Ala Gln Leu Asp Gly Pro Glu Ile Met Thr Asp Met Phe Val Arg 
        115                 120                 125             
Asp Ile Glu His Gly Ile Ala Asp Thr Gly Ile Lys Ala Gly Ile Leu 
    130                 135                 140                 
Lys Cys Ala Thr Asp Glu Pro Gly Leu Thr Pro Gly Val Glu Arg Val 
145                 150                 155                 160 
Leu Arg Ala Val Ala Gln Ala His Lys Arg Thr Gly Ala Pro Ile Ser 
                165                 170                 175     
Thr His Thr His Ala Gly Leu Arg Arg Gly Leu Asp Gln Gln Arg Ile 
            180                 185                 190         
Phe Ala Glu Glu Gly Val Asp Leu Ser Arg Val Val Ile Gly His Cys 
        195                 200                 205             
Gly Asp Ser Thr Asp Val Gly Tyr Leu Glu Glu Leu Ile Ala Ala Gly 
    210                 215                 220                 
Ser Tyr Leu Gly Met Asp Arg Phe Gly Val Asp Val Ile Ser Pro Phe 
225                 230                 235                 240 
Gln Asp Arg Val Asn Ile Val Ala Arg Met Cys Glu Arg Gly His Ala 
                245                 250                 255     
Asp Lys Met Val Leu Ser His Asp Ala Cys Cys Tyr Phe Asp Ala Leu 
            260                 265                 270         
Pro Glu Glu Leu Val Pro Val Ala Met Pro Asn Trp His Tyr Leu His 
        275                 280                 285             
Ile His Asn Asp Val Ile Pro Ala Leu Lys Gln His Gly Val Thr Asp 
    290                 295                 300                 
Glu Gln Leu His Thr Met Leu Val Asp Asn Pro Arg Arg Ile Phe Glu 
305                 310                 315                 320 
Arg Gln Gly Gly Tyr Gln 
                325     

<210> 7
<211> 365
<212> PRT
<213> Chryseobacterium balustinum


<400> 7
Met Gln Thr Arg Arg Val Val Leu Lys Ser Ala Ala Ala Ala Gly Thr 
1               5                   10                  15      
Leu Leu Gly Arg Leu Ala Gly Cys Ala Ser Val Ala Gly Ser Ile Gly 
            20                  25                  30          
Thr Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr Asn Ser Glu 
        35                  40                  45              
Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Thr Ser Ala Gly 
    50                  55                  60                  
Phe Leu Arg Ala Trp Gln Glu Phe Phe Gly Ser Arg Lys Ala Leu Ala 
65                  70                  75                  80  
Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala Gly Val Arg 
                85                  90                  95      
Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp Val Ser Leu 
            100                 105                 110         
Leu Ala Glu Val Ser Met Met Val Asp Val Ser Leu Leu Ala Glu Thr 
        115                 120                 125             
Gly Leu Trp Phe Asp Pro Pro Leu Ser Ile Gly Leu Arg Ser Val Glu 
    130                 135                 140                 
Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp 
145                 150                 155                 160 
Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Thr Gly Lys Ala 
                165                 170                 175     
Thr Pro Phe Gln Glu Leu Val Leu Lys Ala Ala Ala Arg Ala Ser Leu 
            180                 185                 190         
Ala Thr Gly Val Pro Val Thr Thr His Thr Ala Ala Ser Gln Arg Asp 
        195                 200                 205             
Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu Ser Pro Ser 
    210                 215                 220                 
Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu Ser Tyr Leu 
225                 230                 235                 240 
Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp His Ile Pro 
                245                 250                 255     
His Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser Ala Leu Leu 
            260                 265                 270         
Gly Ile Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile 
        275                 280                 285             
Asp Gln Gly Tyr Met Lys Gln Ile Leu Val Ser Asn Asp Trp Leu Phe 
    290                 295                 300                 
Gly Phe Ser Ser Tyr Val Thr Asn Ile Met Asp Val Met Asp Arg Val 
305                 310                 315                 320 
Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile Pro Phe Leu 
                325                 330                 335     
Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Gly Ile Thr Val Thr 
            340                 345                 350         
Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
        355                 360                 365 

<210> 8
<211> 314
<212> PRT
<213> Sulfolobus solfataricus


<400> 8
Met Arg Ile Pro Leu Val Gly Lys Asp Ser Ile Glu Ser Lys Asp Ile 
1               5                   10                  15      
Gly Phe Thr Leu Ile His Glu His Leu Arg Val Phe Ser Glu Ala Ala 
            20                  25                  30          
Arg Gln Gln Trp Pro His Leu Tyr Asn Glu Asp Glu Glu Phe Arg Asn 
        35                  40                  45              
Ala Val Asn Glu Val Lys Arg Ala Met Gln Phe Gly Val Lys Thr Ile 
    50                  55                  60                  
Val Asp Pro Thr Val Met Gly Leu Gly Arg Asp Ile Arg Phe Met Glu 
65                  70                  75                  80  
Lys Val Val Lys Ala Thr Gly Ile Asn Leu Val Ala Gly Thr Gly Ile 
                85                  90                  95      
Tyr Ile Tyr Ile Asp Leu Pro Phe Tyr Phe Leu Asn Arg Ser Ile Asp 
            100                 105                 110         
Glu Ile Ala Asp Leu Phe Ile His Asp Ile Lys Glu Gly Ile Gln Gly 
        115                 120                 125             
Thr Leu Asn Lys Ala Gly Phe Val Lys Ile Ala Ala Asp Glu Pro Gly 
    130                 135                 140                 
Ile Thr Lys Asp Val Glu Lys Val Ile Arg Ala Ala Ala Ile Ala Asn 
145                 150                 155                 160 
Lys Glu Thr Lys Val Pro Ile Ile Thr His Ser Asn Ala His Asn Asn 
                165                 170                 175     
Thr Gly Leu Glu Gln Gln Arg Ile Leu Thr Glu Glu Gly Val Asp Pro 
            180                 185                 190         
Gly Lys Ile Leu Ile Gly His Leu Gly Asp Thr Asp Asn Ile Asp Tyr 
        195                 200                 205             
Ile Lys Lys Ile Ala Asp Lys Gly Ser Phe Ile Gly Leu Asp Arg Tyr 
    210                 215                 220                 
Gly Leu Asp Leu Phe Leu Pro Val Asp Lys Arg Asn Glu Thr Thr Leu 
225                 230                 235                 240 
Arg Leu Ile Lys Asp Gly Tyr Ser Asp Lys Ile Met Ile Ser His Asp 
                245                 250                 255     
Tyr Cys Cys Thr Ile Asp Trp Gly Thr Ala Lys Pro Glu Tyr Lys Pro 
            260                 265                 270         
Lys Leu Ala Pro Arg Trp Ser Ile Thr Leu Ile Phe Glu Asp Thr Ile 
        275                 280                 285             
Pro Phe Leu Lys Arg Asn Gly Val Asn Glu Glu Val Ile Ala Thr Ile 
    290                 295                 300                 
Phe Lys Glu Asn Pro Lys Lys Phe Phe Ser 
305                 310                 

<210> 9
<211> 314
<212> PRT
<213> Artificial Sequence

<220> 
<223> mutant phosphotriesterase

<400> 9
Met Arg Ile Pro Leu Val Gly Lys Asp Ser Ile Glu Ser Lys Asp Ile 
1               5                   10                  15      
Gly Phe Thr Leu Ile His Glu His Leu Arg Val Phe Ser Glu Ala Ala 
            20                  25                  30          
Arg Gln Gln Trp Pro His Leu Tyr Asn Glu Asp Glu Glu Phe Arg Asn 
        35                  40                  45              
Ala Val Asn Glu Val Lys Arg Ala Met Gln Phe Gly Val Lys Thr Ile 
    50                  55                  60                  
Val Asp Pro Thr Val Met Gly Leu Gly Arg Asp Ile Arg Phe Met Glu 
65                  70                  75                  80  
Lys Val Val Lys Ala Thr Gly Ile Asn Leu Val Ala Gly Thr Gly Ile 
                85                  90                  95      
Trp Ile Phe Ile Asp Leu Pro Phe Tyr Phe Leu Asn Arg Ser Ile Asp 
            100                 105                 110         
Glu Ile Ala Asp Leu Phe Ile His Asp Ile Lys Glu Gly Ile Gln Gly 
        115                 120                 125             
Thr Leu Asn Lys Ala Gly Phe Val Lys Ile Ala Ala Asp Glu Pro Gly 
    130                 135                 140                 
Ile Thr Lys Asp Val Glu Lys Val Ile Arg Ala Ala Ala Ile Ala Asn 
145                 150                 155                 160 
Lys Glu Thr Lys Val Pro Ile Ile Thr His Ser Asn Ala His Asn Asn 
                165                 170                 175     
Thr Gly Leu Glu Gln Gln Arg Ile Leu Thr Glu Glu Gly Val Asp Pro 
            180                 185                 190         
Gly Lys Ile Leu Ile Gly His Leu Gly Asp Thr Asp Asn Ile Asp Tyr 
        195                 200                 205             
Ile Lys Lys Ile Ala Asp Lys Gly Ser Phe Ile Gly Leu Asp His Tyr 
    210                 215                 220                 
Gly Leu Asp Leu Phe Leu Pro Val Asp Lys Arg Asn Glu Thr Thr Leu 
225                 230                 235                 240 
Arg Leu Ile Lys Asp Gly Tyr Ser Asp Lys Ile Met Ile Ser His Asp 
                245                 250                 255     
Tyr Leu Cys Thr Ile Asp Trp Gly Thr Ala Lys Pro Glu Tyr Lys Pro 
            260                 265                 270         
Lys Leu Ala Pro Arg Trp Ser Ile Thr Leu Ile Phe Glu Asp Thr Ile 
        275                 280                 285             
Pro Phe Leu Lys Arg Asn Gly Val Asn Glu Glu Val Ile Ala Thr Ile 
    290                 295                 300                 
Phe Lys Glu Asn Pro Lys Lys Phe Phe Ser 
305                 310                 

<210> 10
<211> 314
<212> PRT
<213> Artificial Sequence

<220> 
<223> mutant phosphotriesterase

<400> 10
Met Arg Ile Pro Leu Val Gly Lys Asp Ser Ile Glu Ser Lys Asp Ile 
1               5                   10                  15      
Gly Phe Thr Leu Ile His Glu His Leu Arg Ala Phe Ser Glu Ala Ala 
            20                  25                  30          
Arg Gln Gln Trp Pro His Leu Tyr Asn Glu Asp Glu Glu Phe Arg Asn 
        35                  40                  45              
Ala Val Asn Glu Val Lys Arg Ala Met Gln Phe Gly Val Lys Thr Ile 
    50                  55                  60                  
Val Asp Pro Thr Val Met Gly Ile Gly Arg Asp Ile Arg Phe Met Glu 
65                  70                  75                  80  
Lys Val Val Lys Ala Thr Gly Ile Asn Leu Val Ala Gly Thr Gly Ile 
                85                  90                  95      
Trp Ile Phe Ile Asp Leu Pro Phe Tyr Phe Leu Asn Arg Ser Ile Asp 
            100                 105                 110         
Glu Ile Ala Asp Leu Phe Ile His Asp Ile Lys Glu Gly Ile Gln Gly 
        115                 120                 125             
Thr Leu Asn Lys Ala Gly Phe Val Lys Ile Ala Ala Thr Glu Pro Gly 
    130                 135                 140                 
Ile Thr Lys Asp Val Glu Lys Val Ile Arg Ala Ala Ala Ile Ala Asn 
145                 150                 155                 160 
Lys Glu Thr Lys Val Pro Ile Ile Thr His Ser Asn Ala His Asn Asn 
                165                 170                 175     
Thr Gly Leu Glu Gln Gln Arg Ile Leu Thr Glu Glu Gly Val Asp Pro 
            180                 185                 190         
Gly Lys Ile Leu Ile Gly His Leu Gly Asp Thr Asp Asn Ile Asp Tyr 
        195                 200                 205             
Ile Lys Lys Ile Ala Asp Lys Gly Ser Phe Ile Gly Leu Asp His Tyr 
    210                 215                 220                 
Pro His Asp Leu Phe Leu Pro Val Asp Lys Arg Asn Glu Thr Thr Leu 
225                 230                 235                 240 
Arg Leu Ile Lys Asp Gly Tyr Ser Asp Lys Ile Met Ile Ser His Asp 
                245                 250                 255     
Tyr Leu Cys Thr Ile Asp Trp Gly Thr Ala Lys Pro Glu Tyr Lys Pro 
            260                 265                 270         
Lys Leu Ala Pro Arg Trp Ser Ile Thr Leu Ile Phe Glu Asp Thr Ile 
        275                 280                 285             
Pro Phe Leu Lys Arg Asn Gly Val Asn Glu Glu Val Ile Ala Thr Ile 
    290                 295                 300                 
Phe Lys Glu Asn Pro Lys Lys Phe Phe Ser 
305                 310                 

<210> 11
<211> 314
<212> PRT
<213> Artificial Sequence

<220> 
<223> mutant phosphotriesterase

<400> 11
Met Arg Ile Pro Leu Val Gly Lys Asp Ser Ile Glu Ser Lys Asp Ile 
1               5                   10                  15      
Gly Phe Thr Leu Ile His Glu His Leu Arg Ala Phe Ser Glu Ala Ala 
            20                  25                  30          
Arg Gln Gln Trp Pro His Leu Tyr Asn Glu Asp Glu Glu Phe Arg Asn 
        35                  40                  45              
Ala Val Asn Glu Val Lys Arg Ala Met Gln Phe Gly Val Lys Thr Ile 
    50                  55                  60                  
Val Asp Val Ser Val Met Gly Ile Gly Arg Asp Ile Arg Phe Met Glu 
65                  70                  75                  80  
Lys Val Val Lys Ala Thr Gly Ile Asn Leu Val Ala Gly Thr Gly Ile 
                85                  90                  95      
Trp Ile Phe Ile Asp Leu Pro Phe Tyr Phe Leu Asn Arg Ser Ile Asp 
            100                 105                 110         
Glu Ile Ala Asp Leu Phe Ile His Asp Ile Lys Glu Gly Ile Gln Gly 
        115                 120                 125             
Thr Leu Asn Lys Ala Gly Phe Val Lys Ile Ala Ala Thr Glu Pro Gly 
    130                 135                 140                 
Ile Thr Lys Asp Val Glu Lys Val Ile Arg Ala Ala Ala Ile Ala Asn 
145                 150                 155                 160 
Lys Glu Thr Lys Val Pro Ile Ile Thr His Ser Asn Ala His Asn Asn 
                165                 170                 175     
Thr Gly Leu Glu Gln Gln Arg Ile Leu Thr Glu Glu Gly Val Asp Pro 
            180                 185                 190         
Gly Lys Ile Leu Ile Gly His Leu Gly Asp Thr Asp Asn Ile Asp Tyr 
        195                 200                 205             
Ile Lys Lys Ile Ala Asp Lys Gly Ser Phe Ile Gly Leu Asp His Tyr 
    210                 215                 220                 
Pro His Asp Leu Ser Leu Pro Val Asp Lys Arg Asn Glu Thr Thr Leu 
225                 230                 235                 240 
Arg Leu Ile Lys Asp Gly Tyr Ser Asp Lys Ile Met Ile Ser His Asp 
                245                 250                 255     
Tyr Leu Cys Thr Ile Asp Ala Gly Thr Ala Lys Pro Glu Tyr Lys Pro 
            260                 265                 270         
Lys Leu Ala Pro Arg Ile Ser Ile Thr Leu Ile Phe Glu Asp Thr Ile 
        275                 280                 285             
Pro Phe Leu Lys Arg Asn Gly Val Asn Glu Glu Val Ile Ala Thr Ile 
    290                 295                 300                 
Phe Lys Glu Asn Pro Lys Lys Phe Phe Ser 
305                 310                 

<210> 12
<211> 315
<212> PRT
<213> Sulfolobus acidocaldarius


<400> 12
Met Thr Lys Ile Pro Leu Val Gly Lys Gly Glu Ile Ser Pro Gly Glu 
1               5                   10                  15      
Met Gly Phe Thr Leu Ile His Glu His Leu Arg Val Phe Ser Glu Pro 
            20                  25                  30          
Val Arg Tyr Gln Trp Pro His Leu Tyr Asn Glu Asp Glu Glu Leu Lys 
        35                  40                  45              
Asn Ala Val Asn Glu Val Lys Thr Ile Met Ser Tyr Gly Val Lys Thr 
    50                  55                  60                  
Ile Val Asp Pro Thr Val Met Gly Leu Gly Arg Asp Ile Arg Phe Ser 
65                  70                  75                  80  
Glu Lys Val Val Lys Glu Thr Gly Ile Asn Val Ile Ala Ala Thr Gly 
                85                  90                  95      
Leu Tyr Thr Tyr Thr Asp Leu Pro Phe Phe Phe Asn Gly Arg Ser Leu 
            100                 105                 110         
Glu Glu Ile Ala Glu Leu Leu Ile His Asp Ile Lys Lys Gly Ile Gln 
        115                 120                 125             
Gly Thr Asn Asn Arg Ala Gly Phe Ile Lys Val Ala Ala Asp Glu Pro 
    130                 135                 140                 
Gly Ile Thr Arg Asp Val Glu Arg Ala Ile Arg Ala Ala Ala Ile Ala 
145                 150                 155                 160 
Gln Lys Glu Thr Asn Val Pro Ile Ile Thr His Ser Asn Ala His Asn 
                165                 170                 175     
Gly Thr Gly Leu Glu Gln Gln Arg Ile Leu Met Glu Glu Gly Val Asp 
            180                 185                 190         
Pro Gly Arg Val Leu Ile Gly His Leu Gly Asp Thr Asp Asn Val Asp 
        195                 200                 205             
Tyr Ile Lys Lys Ile Ala Asp Lys Gly Ser Phe Val Gly Leu Asp Arg 
    210                 215                 220                 
Tyr Gly Leu Asp Leu Phe Leu Pro Ile Asp Lys Arg Asn Glu Val Leu 
225                 230                 235                 240 
Leu Lys Leu Ile Lys Asp Gly Tyr Leu Asp Arg Ile Met Val Ser Gln 
                245                 250                 255     
Asp Tyr Cys Cys Thr Ile Asp Trp Gly Ile Ala Lys Pro Glu Tyr Lys 
            260                 265                 270         
Pro Lys Leu Ala Pro Lys Trp Ser Met Ser Leu Ile Phe Thr Asp Val 
        275                 280                 285             
Ile Pro Ser Ile Lys Arg Ala Gly Val Thr Asp Glu Gln Leu His Val 
    290                 295                 300                 
Ile Phe Val Lys Asn Pro Ala Arg Leu Phe Ser 
305                 310                 315 

<210> 13
<211> 315
<212> PRT
<213> Artificial Sequence

<220> 
<223> mutant phosphotriesterase

<400> 13
Met Thr Lys Ile Pro Leu Val Gly Lys Gly Glu Ile Ser Pro Gly Glu 
1               5                   10                  15      
Met Gly Phe Thr Leu Ile His Glu His Leu Arg Val Phe Ser Glu Pro 
            20                  25                  30          
Val Arg Tyr Gln Trp Pro His Leu Tyr Asn Glu Asp Glu Glu Leu Lys 
        35                  40                  45              
Asn Ala Val Asn Glu Val Lys Thr Ile Met Ser Tyr Gly Val Lys Thr 
    50                  55                  60                  
Ile Val Asp Pro Thr Val Met Gly Leu Gly Arg Asp Ile Arg Phe Ser 
65                  70                  75                  80  
Glu Lys Val Val Lys Glu Thr Gly Ile Asn Val Ile Ala Ala Thr Gly 
                85                  90                  95      
Leu Trp Thr Phe Thr Asp Leu Pro Phe Phe Phe Asn Gly Arg Ser Leu 
            100                 105                 110         
Glu Glu Ile Ala Glu Leu Leu Ile His Asp Ile Lys Lys Gly Ile Gln 
        115                 120                 125             
Gly Thr Asn Asn Arg Ala Gly Phe Ile Lys Val Ala Ala Asp Glu Pro 
    130                 135                 140                 
Gly Ile Thr Arg Asp Val Glu Arg Ala Ile Arg Ala Ala Ala Ile Ala 
145                 150                 155                 160 
Gln Lys Glu Thr Asn Val Pro Ile Ile Thr His Ser Asn Ala His Asn 
                165                 170                 175     
Gly Thr Gly Leu Glu Gln Gln Arg Ile Leu Met Glu Glu Gly Val Asp 
            180                 185                 190         
Pro Gly Arg Val Leu Ile Gly His Leu Gly Asp Thr Asp Asn Val Asp 
        195                 200                 205             
Tyr Ile Lys Lys Ile Ala Asp Lys Gly Ser Phe Val Gly Leu Asp His 
    210                 215                 220                 
Tyr Gly Leu Asp Leu Phe Leu Pro Ile Asp Lys Arg Asn Glu Val Leu 
225                 230                 235                 240 
Leu Lys Leu Ile Lys Asp Gly Tyr Leu Asp Arg Ile Met Val Ser Gln 
                245                 250                 255     
Asp Tyr Leu Cys Thr Ile Asp Trp Gly Ile Ala Lys Pro Glu Tyr Lys 
            260                 265                 270         
Pro Lys Leu Ala Pro Lys Trp Ser Met Ser Leu Ile Phe Thr Asp Val 
        275                 280                 285             
Ile Pro Ser Ile Lys Arg Ala Gly Val Thr Asp Glu Gln Leu His Val 
    290                 295                 300                 
Ile Phe Val Lys Asn Pro Ala Arg Leu Phe Ser 
305                 310                 315 

<210> 14
<211> 315
<212> PRT
<213> Artificial Sequence

<220> 
<223> mutant phosphotriesterase

<400> 14
Met Thr Lys Ile Pro Leu Val Gly Lys Gly Glu Ile Ser Pro Gly Glu 
1               5                   10                  15      
Met Gly Phe Thr Leu Ile His Glu His Leu Arg Ala Phe Ser Glu Pro 
            20                  25                  30          
Val Arg Tyr Gln Trp Pro His Leu Tyr Asn Glu Asp Glu Glu Leu Lys 
        35                  40                  45              
Asn Ala Val Asn Glu Val Lys Thr Ile Met Ser Tyr Gly Val Lys Thr 
    50                  55                  60                  
Ile Val Asp Pro Thr Val Met Gly Ile Gly Arg Asp Ile Arg Phe Ser 
65                  70                  75                  80  
Glu Lys Val Val Lys Glu Thr Gly Ile Asn Val Ile Ala Ala Thr Gly 
                85                  90                  95      
Leu Trp Thr Phe Thr Asp Leu Pro Phe Phe Phe Asn Gly Arg Ser Leu 
            100                 105                 110         
Glu Glu Ile Ala Glu Leu Leu Ile His Asp Ile Lys Lys Gly Ile Gln 
        115                 120                 125             
Gly Thr Asn Asn Arg Ala Gly Phe Ile Lys Val Ala Ala Thr Glu Pro 
    130                 135                 140                 
Gly Ile Thr Arg Asp Val Glu Arg Ala Ile Arg Ala Ala Ala Ile Ala 
145                 150                 155                 160 
Gln Lys Glu Thr Asn Val Pro Ile Ile Thr His Ser Asn Ala His Asn 
                165                 170                 175     
Gly Thr Gly Leu Glu Gln Gln Arg Ile Leu Met Glu Glu Gly Val Asp 
            180                 185                 190         
Pro Gly Arg Val Leu Ile Gly His Leu Gly Asp Thr Asp Asn Val Asp 
        195                 200                 205             
Tyr Ile Lys Lys Ile Ala Asp Lys Gly Ser Phe Val Gly Leu Asp His 
    210                 215                 220                 
Tyr Pro His Asp Leu Phe Leu Pro Ile Asp Lys Arg Asn Glu Val Leu 
225                 230                 235                 240 
Leu Lys Leu Ile Lys Asp Gly Tyr Leu Asp Arg Ile Met Val Ser Gln 
                245                 250                 255     
Asp Tyr Leu Cys Thr Ile Asp Trp Gly Ile Ala Lys Pro Glu Tyr Lys 
            260                 265                 270         
Pro Lys Leu Ala Pro Lys Trp Ser Met Ser Leu Ile Phe Thr Asp Val 
        275                 280                 285             
Ile Pro Ser Ile Lys Arg Ala Gly Val Thr Asp Glu Gln Leu His Val 
    290                 295                 300                 
Ile Phe Val Lys Asn Pro Ala Arg Leu Phe Ser 
305                 310                 315 

<210> 15
<211> 315
<212> PRT
<213> Artificial Sequence

<220> 
<223> mutant phosphotriesterase

<400> 15
Met Thr Lys Ile Pro Leu Val Gly Lys Gly Glu Ile Ser Pro Gly Glu 
1               5                   10                  15      
Met Gly Phe Thr Leu Ile His Glu His Leu Arg Ala Phe Ser Glu Pro 
            20                  25                  30          
Val Arg Tyr Gln Trp Pro His Leu Tyr Asn Glu Asp Glu Glu Leu Lys 
        35                  40                  45              
Asn Ala Val Asn Glu Val Lys Thr Ile Met Ser Tyr Gly Val Lys Thr 
    50                  55                  60                  
Ile Val Asp Val Ser Val Met Gly Ile Gly Arg Asp Ile Arg Phe Ser 
65                  70                  75                  80  
Glu Lys Val Val Lys Glu Thr Gly Ile Asn Val Ile Ala Ala Thr Gly 
                85                  90                  95      
Leu Trp Thr Phe Thr Asp Leu Pro Phe Phe Phe Asn Gly Arg Ser Leu 
            100                 105                 110         
Glu Glu Ile Ala Glu Leu Leu Ile His Asp Ile Lys Lys Gly Ile Gln 
        115                 120                 125             
Gly Thr Asn Asn Arg Ala Gly Phe Ile Lys Val Ala Ala Thr Glu Pro 
    130                 135                 140                 
Gly Ile Thr Arg Asp Val Glu Arg Ala Ile Arg Ala Ala Ala Ile Ala 
145                 150                 155                 160 
Gln Lys Glu Thr Asn Val Pro Ile Ile Thr His Ser Asn Ala His Asn 
                165                 170                 175     
Gly Thr Gly Leu Glu Gln Gln Arg Ile Leu Met Glu Glu Gly Val Asp 
            180                 185                 190         
Pro Gly Arg Val Leu Ile Gly His Leu Gly Asp Thr Asp Asn Val Asp 
        195                 200                 205             
Tyr Ile Lys Lys Ile Ala Asp Lys Gly Ser Phe Val Gly Leu Asp His 
    210                 215                 220                 
Tyr Pro His Asp Leu Ser Leu Pro Ile Asp Lys Arg Asn Glu Val Leu 
225                 230                 235                 240 
Leu Lys Leu Ile Lys Asp Gly Tyr Leu Asp Arg Ile Met Val Ser Gln 
                245                 250                 255     
Asp Tyr Leu Cys Thr Ile Asp Ala Gly Ile Ala Lys Pro Glu Tyr Lys 
            260                 265                 270         
Pro Lys Leu Ala Pro Lys Ile Ser Met Ser Leu Ile Phe Thr Asp Val 
        275                 280                 285             
Ile Pro Ser Ile Lys Arg Ala Gly Val Thr Asp Glu Gln Leu His Val 
    290                 295                 300                 
Ile Phe Val Lys Asn Pro Ala Arg Leu Phe Ser 
305                 310                 315 

<210> 16
<211> 355
<212> PRT
<213> Homo sapiens


<400> 16
Met Ala Lys Leu Ile Ala Leu Thr Leu Leu Gly Met Gly Leu Ala Leu 
1               5                   10                  15      
Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg 
            20                  25                  30          
Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile 
        35                  40                  45              
Glu Thr Gly Ser Glu Asp Met Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  
Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn 
65                  70                  75                  80  
Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr 
                85                  90                  95      
Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe 
            100                 105                 110         
Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr 
        115                 120                 125             
Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe 
    130                 135                 140                 
Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 
His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     
His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Gln 
            180                 185                 190         
Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr 
        195                 200                 205             
Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 
Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 
Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     
Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         
Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             
Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val 
    290                 295                 300                 
Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val 
305                 310                 315                 320 
Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val 
                325                 330                 335     
Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         
Cys Glu Leu 
        355 

<210> 17
<211> 351
<212> PRT
<213> Musca domestica


<400> 17
Met Pro Ile Val Gln Thr Val Leu Gly Pro Ile Asp Pro Asn Leu Leu 
1               5                   10                  15      
Gly Arg Thr Leu Thr His Glu His Ile Ala Leu Asp Phe Glu Gly Phe 
            20                  25                  30          
His Cys Asp Pro Pro Glu Asp Phe Lys Pro Phe Leu Glu Gly Lys Leu 
        35                  40                  45              
Arg Met Glu Asn Leu Gly Phe Val Arg Gln Tyr Pro Tyr Ser Ser Arg 
    50                  55                  60                  
Asp Asn Thr Arg Phe Tyr Asp Glu Glu Thr Arg Val Ala Val Leu Lys 
65                  70                  75                  80  
Asp Ile Glu Leu Tyr Lys Lys Phe Gly Gly Gly Thr Ile Val Glu Asn 
                85                  90                  95      
Ser Ser His Gly Leu Lys Arg Asn Met Glu Phe Met Val Glu Ala Ser 
            100                 105                 110         
Lys Lys Thr Gly Val His Ile Val Ala Gly Thr Gly His Tyr Val His 
        115                 120                 125             
Asp Leu Gln Glu Lys Asp His Val Gly Met Thr Val Glu Gln Met Thr 
    130                 135                 140                 
Asp Leu Tyr Ser Lys Glu Ile Ile Thr Gly Val Glu Leu Glu Gly Val 
145                 150                 155                 160 
Gly Met Val Lys Cys Gly Phe Ile Gly Glu Val Gly Ser Val Tyr Pro 
                165                 170                 175     
Ile His Asp Phe Glu Lys Arg Ala Ile Lys Ala Thr Gly Glu Ile Gln 
            180                 185                 190         
Glu Val Leu Gly Cys Gly Val Ser Phe His Pro Gly Arg Asp Ala Glu 
        195                 200                 205             
Ala Pro Phe Glu Ile Val Arg Leu Tyr Leu Glu Ala Gly Gly Lys Ala 
    210                 215                 220                 
Ser Lys Cys Val Met Ser His Leu Asp Arg Thr Ile Phe Asp Ile Asp 
225                 230                 235                 240 
Gln Leu Leu Glu Phe Ala Lys Met Gly Thr Tyr Ile Gln Tyr Asp Leu 
                245                 250                 255     
Phe Gly Thr Glu Cys Ser Leu Tyr Gln Leu Asn Leu Thr Val Asp Met 
            260                 265                 270         
Pro Ser Asp Ala Gln Arg Ile Asn Asn Leu Met Arg Leu Ile Asp Glu 
        275                 280                 285             
Gly Tyr Val Asp Lys Ile Leu Met Ser His Asp Leu His Thr Lys His 
    290                 295                 300                 
Arg Leu Thr Ser Phe Gly Gly His Gly Tyr His His Val His Met Asn 
305                 310                 315                 320 
Ile Leu Pro Arg Met Phe Ala Lys Gly Leu Ser Val Glu Gln Ile Glu 
                325                 330                 335     
Gln Met Thr Val Thr Asn Pro Ala Lys Trp Leu Glu Phe Asn Ile 
            340                 345                 350     

<210> 18
<211> 350
<212> PRT
<213> Drosophila melanogaster


<400> 18
Met Ser Thr Val Gln Thr Val Leu Gly Thr Ile Thr Pro Asn Leu Leu 
1               5                   10                  15      
Gly Arg Thr Leu Thr His Glu His Val Ala Leu Asp Phe Glu His Phe 
            20                  25                  30          
Tyr Arg Pro Pro Pro Pro Asp Phe Glu Ser Glu Leu Lys Ala Lys Ile 
        35                  40                  45              
Ser Met Ser Thr Leu Gly Tyr Val Arg Leu Tyr Pro Tyr Ser Ser Lys 
    50                  55                  60                  
Glu Asn Val Arg Phe Tyr Asp Gly Glu Ala Leu Glu Ala Ala Lys Lys 
65                  70                  75                  80  
Asp Val Leu Leu Tyr Lys Lys His Gly Gly Gly Ser Ile Val Glu Asn 
                85                  90                  95      
Ser Ser Tyr Gly Leu Lys Arg Asn Leu Glu Phe Ile Val Glu Leu Ala 
            100                 105                 110         
Lys Ser Thr Gly Val His Phe Ile Ala Gly Thr Gly His Tyr Ile His 
        115                 120                 125             
Ala Met Gln Asp Ala Ser His Ala Ser Leu Thr Val Glu Gln Met Ser 
    130                 135                 140                 
Asp Leu Tyr Ser Lys Asp Ile Ile Thr Gly Leu Gln Val Asn Gly Lys 
145                 150                 155                 160 
Val Val Lys Cys Gly Phe Ile Gly Glu Val Ala Ser Val Tyr Pro Ile 
                165                 170                 175     
His Asp Phe Glu Lys Asn Ala Ile Lys Ala Ala Gly Glu Ile Gln Glu 
            180                 185                 190         
Val Leu Gly Cys Gly Val Ser Met His Pro His Arg Val Thr Lys Ala 
        195                 200                 205             
Pro Phe Glu Ile Met Arg Leu Tyr Leu Glu Ala Gly Gly Arg Ala Asp 
    210                 215                 220                 
Lys Cys Val Met Ser His Leu Asp Arg Thr Ile Phe Asp Ile Asp Glu 
225                 230                 235                 240 
Leu Leu Glu Phe Ala Lys Leu Gly Cys Tyr Ile Gln Tyr Asp Leu Phe 
                245                 250                 255     
Gly Thr Glu Cys Ser Phe Tyr Gln Leu Asn Thr Ser Val Asp Met Ile 
            260                 265                 270         
Ser Asp Gly Gln Arg Ile Asp Asn Leu Ile Lys Leu Ile Lys Glu Gly 
        275                 280                 285             
Leu Val Asp Lys Leu Leu Met Ser His Asp Ile His Thr Lys His Arg 
    290                 295                 300                 
Leu Thr Ser Tyr Gly Gly His Gly Tyr His His Ile His Thr Asn Ile 
305                 310                 315                 320 
Leu Pro Arg Met Phe Asp Arg Gly Val Thr Leu Glu Gln Val Glu Gln 
                325                 330                 335     
Met Thr Val Thr Asn Pro Ala Lys Trp Leu Ala Phe Asp Pro 
            340                 345                 350 

<210> 19
<211> 384
<212> PRT
<213> Artificial Sequence

<220> 
<223> mutant OPDA

<400> 19
Met Gln Thr Arg Arg Asp Ala Leu Lys Ser Ala Ala Ala Ile Thr Leu 
1               5                   10                  15      
Leu Gly Gly Leu Ala Gly Cys Ala Ser Met Ala Arg Pro Ile Gly Thr 
            20                  25                  30          
Gly Asp Leu Ile Asn Thr Val Arg Gly Ser Ile Pro Val Ser Glu Ala 
        35                  40                  45              
Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser Ser Ala Gly Phe 
    50                  55                  60                  
Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Lys Ala Leu Ala Glu 
65                  70                  75                  80  
Lys Ala Val Arg Gly Leu Arg His Ala Arg Ser Ala Gly Val Gln Thr 
                85                  90                  95      
Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp Val Arg Leu Leu 
            100                 105                 110         
Ala Glu Val Ser Arg Ala Ala Asp Val His Ile Val Ala Ala Thr Gly 
        115                 120                 125             
Leu Trp Phe Asp Pro Ser Leu Ser Met Arg Met Arg Ser Val Glu Glu 
    130                 135                 140                 
Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln His Gly Ile Glu Asp Thr 
145                 150                 155                 160 
Gly Ile Arg Ala Gly Ile Ile Lys Val Ser Thr Thr Gly Lys Ala Thr 
                165                 170                 175     
Pro Phe Gln Glu Leu Val Leu Lys Ala Ala Ala Arg Ala Ser Leu Ala 
            180                 185                 190         
Thr Gly Val Pro Val Thr Thr His Thr Ser Ala Ser Gln Arg Asp Gly 
        195                 200                 205             
Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu Ser Pro Ser Arg 
    210                 215                 220                 
Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu Gly Tyr Leu Thr 
225                 230                 235                 240 
Gly Leu Ala Ala Arg Gly Tyr Leu Val Gly Leu Asp Arg Met Pro Tyr 
                245                 250                 255     
Ser Ala Ile Gly Leu Glu Gly Asn Ala Ser Ala Leu Ala Leu Phe Gly 
            260                 265                 270         
Thr Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp 
        275                 280                 285             
Arg Gly Tyr Lys Asp Arg Ile Leu Val Ser His Asp Trp Leu Phe Gly 
    290                 295                 300                 
Phe Ser Ser Tyr Val Thr Asn Ile Met Asp Val Met Asp Arg Ile Asn 
305                 310                 315                 320 
Pro Asp Gly Met Ala Phe Val Pro Leu Arg Val Ile Pro Phe Leu Arg 
                325                 330                 335     
Glu Lys Gly Val Pro Pro Glu Thr Leu Ala Gly Val Thr Val Ala Asn 
            340                 345                 350         
Pro Ala Arg Phe Leu Ser Pro Thr Val Arg Ala Val Val Thr Arg Ser 
        355                 360                 365             
Glu Thr Ser Arg Pro Ala Ala Pro Ile Pro Arg Gln Asp Thr Glu Arg 
    370                 375                 380                 



<210> 20
<211> 356
<212> PRT
<213> Artificial Sequence

<220> 
<223> mutant OPDA

<400> 20
Pro Ile Gly Thr Gly Asp Leu Ile Asn Thr Val Arg Gly Ser Ile Pro 
1               5                   10                  15      
Val Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          
Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Lys 
        35                  40                  45              
Ala Leu Ala Glu Lys Ala Val Arg Gly Leu Arg His Ala Arg Ser Ala 
    50                  55                  60                  
Gly Val Gln Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp 
65                  70                  75                  80  
Val Arg Leu Leu Ala Glu Val Ser Arg Ala Ala Asp Val His Ile Val 
                85                  90                  95      
Ala Ala Thr Gly Leu Trp Phe Asp Pro Ser Leu Ser Met Arg Met Arg 
            100                 105                 110         
Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln His Gly 
        115                 120                 125             
Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ser Thr Thr 
    130                 135                 140                 
Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Lys Ala Ala Ala Arg 
145                 150                 155                 160 
Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Ser Ala Ser 
                165                 170                 175     
Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         
Ser Pro Ser Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu 
        195                 200                 205             
Gly Tyr Leu Thr Gly Leu Ala Ala Arg Gly Tyr Leu Val Gly Leu Asp 
    210                 215                 220                 
Arg Met Pro Tyr Ser Ala Ile Gly Leu Glu Gly Asn Ala Ser Ala Leu 
225                 230                 235                 240 
Ala Leu Phe Gly Thr Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     
Ala Leu Ile Asp Arg Gly Tyr Lys Asp Arg Ile Leu Val Ser His Asp 
            260                 265                 270         
Trp Leu Phe Gly Phe Ser Ser Tyr Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             
Asp Arg Ile Asn Pro Asp Gly Met Ala Phe Val Pro Leu Arg Val Ile 
    290                 295                 300                 
Pro Phe Leu Arg Glu Lys Gly Val Pro Pro Glu Thr Leu Ala Gly Val 
305                 310                 315                 320 
Thr Val Ala Asn Pro Ala Arg Phe Leu Ser Pro Thr Val Arg Ala Val 
                325                 330                 335     
Val Thr Arg Ser Glu Thr Ser Arg Pro Ala Ala Pro Ile Pro Arg Gln 
            340                 345                 350         
Asp Thr Glu Arg 
        355     

<210> 21
<211> 384
<212> PRT
<213> Artificial Sequence

<220> 
<223> mutant OPDA

<400> 21
Met Gln Thr Arg Arg Asp Ala Leu Lys Ser Ala Ala Ala Ile Thr Leu 
1               5                   10                  15      
Leu Gly Gly Leu Ala Gly Cys Ala Ser Met Ala Arg Pro Ile Gly Thr 
            20                  25                  30          
Gly Asp Leu Ile Asn Thr Val Arg Gly Pro Ile Pro Val Ser Glu Ala 
        35                  40                  45              
Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser Ser Ala Gly Phe 
    50                  55                  60                  
Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Lys Ala Leu Ala Glu 
65                  70                  75                  80  
Lys Ala Val Arg Gly Leu Arg His Ala Arg Ser Ala Gly Val Gln Thr 
                85                  90                  95      
Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp Val Arg Leu Leu 
            100                 105                 110         
Ala Glu Val Ser Arg Ala Asp Asp Val His Ile Val Ala Ala Thr Gly 
        115                 120                 125             
Leu Trp Phe Asp Pro Pro Leu Ser Met Arg Met Arg Ser Val Glu Glu 
    130                 135                 140                 
Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln His Gly Ile Glu Asp Thr 
145                 150                 155                 160 
Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Thr Gly Lys Ala Thr 
                165                 170                 175     
Pro Phe Gln Glu Leu Val Leu Lys Ala Ala Ala Arg Ala Ser Leu Ala 
            180                 185                 190         
Thr Gly Val Pro Val Thr Thr His Thr Ser Ala Ser Gln Arg Asp Gly 
        195                 200                 205             
Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu Ser Pro Ser Arg 
    210                 215                 220                 
Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu Ser Tyr Leu Thr 
225                 230                 235                 240 
Gly Leu Ala Ala Arg Gly Tyr Leu Val Gly Leu Asp Arg Met Pro Tyr 
                245                 250                 255     
Ser Ala Ile Gly Leu Glu Gly Asn Ala Ser Ala Leu Ala Leu Phe Gly 
            260                 265                 270         
Thr Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp 
        275                 280                 285             
Arg Gly Tyr Lys Asp Arg Ile Leu Val Ser His Asp Trp Leu Phe Gly 
    290                 295                 300                 
Phe Ser Ser Tyr Val Thr Asn Ile Met Asp Val Met Asp Arg Ile Asn 
305                 310                 315                 320 
Pro Asp Gly Met Ala Phe Val Pro Leu Arg Val Ile Pro Phe Leu Arg 
                325                 330                 335     
Glu Lys Gly Val Pro Pro Glu Thr Leu Ala Gly Val Thr Val Ala Asn 
            340                 345                 350         
Pro Ala Arg Phe Leu Ser Pro Thr Val Arg Ala Val Val Thr Arg Ser 
        355                 360                 365             
Glu Thr Ser Arg Pro Ala Ala Pro Ile Pro Arg Gln Asp Thr Glu Arg 
    370                 375                 380                 



<210> 22
<211> 356
<212> PRT
<213> Artificial Sequence

<220> 
<223> mutant OPDA

<400> 22
Pro Ile Gly Thr Gly Asp Leu Ile Asn Thr Val Arg Gly Pro Ile Pro 
1               5                   10                  15      
Val Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          
Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Lys 
        35                  40                  45              
Ala Leu Ala Glu Lys Ala Val Arg Gly Leu Arg His Ala Arg Ser Ala 
    50                  55                  60                  
Gly Val Gln Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp 
65                  70                  75                  80  
Val Arg Leu Leu Ala Glu Val Ser Arg Ala Asp Asp Val His Ile Val 
                85                  90                  95      
Ala Ala Thr Gly Leu Trp Phe Asp Pro Pro Leu Ser Met Arg Met Arg 
            100                 105                 110         
Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln His Gly 
        115                 120                 125             
Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Thr 
    130                 135                 140                 
Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Lys Ala Ala Ala Arg 
145                 150                 155                 160 
Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Ser Ala Ser 
                165                 170                 175     
Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         
Ser Pro Ser Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu 
        195                 200                 205             
Ser Tyr Leu Thr Gly Leu Ala Ala Arg Gly Tyr Leu Val Gly Leu Asp 
    210                 215                 220                 
Arg Met Pro Tyr Ser Ala Ile Gly Leu Glu Gly Asn Ala Ser Ala Leu 
225                 230                 235                 240 
Ala Leu Phe Gly Thr Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     
Ala Leu Ile Asp Arg Gly Tyr Lys Asp Arg Ile Leu Val Ser His Asp 
            260                 265                 270         
Trp Leu Phe Gly Phe Ser Ser Tyr Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             
Asp Arg Ile Asn Pro Asp Gly Met Ala Phe Val Pro Leu Arg Val Ile 
    290                 295                 300                 
Pro Phe Leu Arg Glu Lys Gly Val Pro Pro Glu Thr Leu Ala Gly Val 
305                 310                 315                 320 
Thr Val Ala Asn Pro Ala Arg Phe Leu Ser Pro Thr Val Arg Ala Val 
                325                 330                 335     
Val Thr Arg Ser Glu Thr Ser Arg Pro Ala Ala Pro Ile Pro Arg Gln 
            340                 345                 350         
Asp Thr Glu Arg 
        355     

<210> 23
<211> 384
<212> PRT
<213> Artificial Sequence

<220> 
<223> mutant OPDA

<400> 23
Met Gln Thr Arg Arg Asp Ala Leu Lys Ser Ala Ala Ala Ile Thr Leu 
1               5                   10                  15      
Leu Gly Gly Leu Ala Gly Cys Ala Ser Met Ala Arg Pro Ile Gly Thr 
            20                  25                  30          
Gly Asp Leu Ile Asn Thr Val Arg Gly Pro Ile Pro Val Ser Glu Ala 
        35                  40                  45              
Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser Ser Ala Gly Phe 
    50                  55                  60                  
Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Lys Ala Leu Ala Glu 
65                  70                  75                  80  
Lys Ala Val Arg Gly Leu Arg His Ala Arg Ser Ala Gly Val Gln Thr 
                85                  90                  95      
Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp Val Arg Leu Leu 
            100                 105                 110         
Ala Glu Val Ser Arg Ala His Asp Val His Ile Val Ala Ala Thr Gly 
        115                 120                 125             
Leu Trp Phe Asp Pro Pro Leu Ser Met Arg Met Arg Ser Val Glu Glu 
    130                 135                 140                 
Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln His Gly Ile Glu Asp Thr 
145                 150                 155                 160 
Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Thr Gly Lys Ala Thr 
                165                 170                 175     
Pro Phe Gln Glu Leu Val Leu Lys Ala Ala Ala Arg Ala Ser Leu Ala 
            180                 185                 190         
Thr Gly Val Pro Val Thr Thr His Thr Ser Ala Ser Gln Arg Asp Gly 
        195                 200                 205             
Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu Ser Pro Ser Arg 
    210                 215                 220                 
Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu Ser Tyr Leu Thr 
225                 230                 235                 240 
Gly Leu Ala Ala Arg Gly Tyr Leu Val Gly Leu Asp Arg Met Pro Tyr 
                245                 250                 255     
Ser Ala Ile Gly Leu Glu Gly Asn Ala Ser Ala Leu Ala Leu Phe Gly 
            260                 265                 270         
Thr Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp 
        275                 280                 285             
Arg Gly Tyr Lys Asp Arg Ile Leu Val Ser His Asp Trp Leu Phe Gly 
    290                 295                 300                 
Phe Ser Ser Phe Val Thr Asn Ile Met Asp Val Met Asp Arg Ile Asn 
305                 310                 315                 320 
Pro Asp Gly Met Ala Phe Val Pro Leu Arg Val Ile Pro Phe Leu Arg 
                325                 330                 335     
Glu Lys Gly Val Pro Pro Glu Thr Leu Ala Gly Val Thr Val Ala Asn 
            340                 345                 350         
Pro Ala Arg Phe Leu Ser Pro Thr Val Arg Ala Val Val Thr Arg Ser 
        355                 360                 365             
Glu Thr Ser Arg Pro Ala Ala Pro Ile Pro Arg Gln Asp Thr Glu Arg 
    370                 375                 380                 



<210> 24
<211> 356
<212> PRT
<213> Artificial Sequence

<220> 
<223> mutant OPDA

<400> 24
Pro Ile Gly Thr Gly Asp Leu Ile Asn Thr Val Arg Gly Pro Ile Pro 
1               5                   10                  15      
Val Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          
Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Lys 
        35                  40                  45              
Ala Leu Ala Glu Lys Ala Val Arg Gly Leu Arg His Ala Arg Ser Ala 
    50                  55                  60                  
Gly Val Gln Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp 
65                  70                  75                  80  
Val Arg Leu Leu Ala Glu Val Ser Arg Ala His Asp Val His Ile Val 
                85                  90                  95      
Ala Ala Thr Gly Leu Trp Phe Asp Pro Pro Leu Ser Met Arg Met Arg 
            100                 105                 110         
Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln His Gly 
        115                 120                 125             
Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Thr 
    130                 135                 140                 
Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Lys Ala Ala Ala Arg 
145                 150                 155                 160 
Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Ser Ala Ser 
                165                 170                 175     
Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         
Ser Pro Ser Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu 
        195                 200                 205             
Ser Tyr Leu Thr Gly Leu Ala Ala Arg Gly Tyr Leu Val Gly Leu Asp 
    210                 215                 220                 
Arg Met Pro Tyr Ser Ala Ile Gly Leu Glu Gly Asn Ala Ser Ala Leu 
225                 230                 235                 240 
Ala Leu Phe Gly Thr Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     
Ala Leu Ile Asp Arg Gly Tyr Lys Asp Arg Ile Leu Val Ser His Asp 
            260                 265                 270         
Trp Leu Phe Gly Phe Ser Ser Phe Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             
Asp Arg Ile Asn Pro Asp Gly Met Ala Phe Val Pro Leu Arg Val Ile 
    290                 295                 300                 
Pro Phe Leu Arg Glu Lys Gly Val Pro Pro Glu Thr Leu Ala Gly Val 
305                 310                 315                 320 
Thr Val Ala Asn Pro Ala Arg Phe Leu Ser Pro Thr Val Arg Ala Val 
                325                 330                 335     
Val Thr Arg Ser Glu Thr Ser Arg Pro Ala Ala Pro Ile Pro Arg Gln 
            340                 345                 350         
Asp Thr Glu Arg 
        355     

<210> 25
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 25
Met Lys Lys Arg Arg Val Val Asn Ser Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      
Ala Ser Ala Leu Ala Leu Thr Val Ala Pro Met Ala Lys Ala 
            20                  25                  30  

<210> 26
<211> 46
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 26
Met Glu Ala Arg Met Thr Gly Arg Arg Lys Val Thr Arg Arg Asp Ala 
1               5                   10                  15      
Met Ala Asp Ala Ala Arg Ala Val Gly Val Ala Cys Leu Gly Gly Phe 
            20                  25                  30          
Ser Leu Ala Ala Leu Val Arg Thr Ala Ser Pro Val Asp Ala 
        35                  40                  45      

<210> 27
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 27
Met Ser Arg Ser Ala Lys Pro Gln Asn Gly Arg Arg Arg Phe Leu Arg 
1               5                   10                  15      
Asp Val Val Arg Thr Ala Gly Gly Leu Ala Ala Val Gly Val Ala Leu 
            20                  25                  30          
Gly Leu Gln Gln Gln Thr Ala Arg Ala 
        35                  40      

<210> 28
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 28
Met Thr Trp Ser Arg Arg Gln Phe Leu Thr Gly Val Gly Val Leu Ala 
1               5                   10                  15      
Ala Val Ser Gly Thr Ala Gly Arg Val Val Ala 
            20                  25          

<210> 29
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 29
Met Asp Arg Arg Arg Phe Leu Thr Leu Leu Gly Ser Ala Gly Leu Thr 
1               5                   10                  15      
Ala Thr Val Ala Thr Ala Gly Thr Ala Lys Ala 
            20                  25          

<210> 30
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 30
Met Ser Glu Lys Asp Lys Met Ile Thr Arg Arg Asp Ala Leu Arg Asn 
1               5                   10                  15      
Ile Ala Val Val Val Gly Ser Val Ala Thr Thr Thr Met Met Gly Val 
            20                  25                  30          
Gly Val Ala Asp Ala 
        35          

<210> 31
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 31
Met Gln Ile Val Asn Leu Thr Arg Arg Gly Phe Leu Lys Ala Ala Cys 
1               5                   10                  15      
Val Val Thr Gly Gly Ala Leu Ile Ser Ile Arg Met Thr Gly Lys Ala 
            20                  25                  30          
Val Ala 
        

<210> 32
<211> 45
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 32
Met Asn Asn Glu Glu Thr Phe Tyr Gln Ala Met Arg Arg Gln Gly Val 
1               5                   10                  15      
Thr Arg Arg Ser Phe Leu Lys Tyr Cys Ser Leu Ala Ala Thr Ser Leu 
            20                  25                  30          
Gly Leu Gly Ala Gly Met Ala Pro Lys Ile Ala Trp Ala 
        35                  40                  45  

<210> 33
<211> 48
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 33
Met Ser Thr Gly Thr Thr Asn Leu Val Arg Thr Leu Asp Ser Met Asp 
1               5                   10                  15      
Phe Leu Lys Met Asp Arg Arg Thr Phe Met Lys Ala Val Ser Ala Leu 
            20                  25                  30          
Gly Ala Thr Ala Phe Leu Gly Thr Tyr Gln Thr Glu Ile Val Asn Ala 
        35                  40                  45              



<210> 34
<211> 50
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 34
Met Lys Cys Tyr Ile Gly Arg Gly Lys Asn Gln Val Glu Glu Arg Leu 
1               5                   10                  15      
Glu Arg Arg Gly Val Ser Arg Arg Asp Phe Met Lys Phe Cys Thr Ala 
            20                  25                  30          
Val Ala Val Ala Met Gly Met Gly Pro Ala Phe Ala Pro Lys Val Ala 
        35                  40                  45              
Glu Ala 
    50  

<210> 35
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 35
Met Asn Arg Arg Asn Phe Ile Lys Ala Ala Ser Cys Gly Ala Leu Leu 
1               5                   10                  15      
Thr Gly Ala Leu Pro Ser Val Ser His Ala 
            20                  25      

<210> 36
<211> 44
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 36
Met Ser His Ala Asp Glu His Ala Gly Asp His Gly Ala Thr Arg Arg 
1               5                   10                  15      
Asp Phe Leu Tyr Tyr Ala Thr Ala Gly Ala Gly Thr Val Ala Ala Gly 
            20                  25                  30          
Ala Ala Ala Trp Thr Leu Val Asn Gln Met Asn Pro 
        35                  40                  

<210> 37
<211> 44
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 37
Met Thr Gln Ile Ser Gly Ser Pro Asp Val Pro Asp Leu Gly Arg Arg 
1               5                   10                  15      
Gln Phe Met Asn Leu Leu Thr Phe Gly Thr Ile Thr Gly Val Ala Ala 
            20                  25                  30          
Gly Ala Leu Tyr Pro Ala Val Lys Tyr Leu Ile Pro 
        35                  40                  

<210> 38
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 38
Met Asp Arg Arg Thr Phe Leu Arg Leu Tyr Leu Leu Val Gly Ala Ala 
1               5                   10                  15      
Ile Ala Val Ala Pro Val Ile Lys Pro Ala Leu Asp Tyr Val Gly Tyr 
            20                  25                  30          



<210> 39
<211> 42
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 39
Met Thr Lys Leu Ser Gly Gln Glu Leu His Ala Glu Leu Ser Arg Arg 
1               5                   10                  15      
Ala Phe Leu Ser Tyr Thr Ala Ala Val Gly Ala Leu Gly Leu Cys Gly 
            20                  25                  30          
Thr Ser Leu Leu Ala Gln Gly Ala Arg Ala 
        35                  40          

<210> 40
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 40
Met Thr Leu Thr Arg Arg Glu Phe Ile Lys His Ser Gly Ile Ala Ala 
1               5                   10                  15      
Gly Ala Leu Val Val Thr Ser Ala Ala Pro Leu Pro Ala Trp Ala 
            20                  25                  30      

<210> 41
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 41
Met Thr Ile Ser Arg Arg Asp Leu Leu Lys Ala Gln Ala Ala Gly Ile 
1               5                   10                  15      
Ala Ala Met Ala Ala Asn Ile Pro Leu Ser Ser Gln Ala Pro Ala 
            20                  25                  30      

<210> 42
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 42
Met Ser Glu Ala Leu Ser Gly Arg Gly Asn Asp Arg Arg Lys Phe Leu 
1               5                   10                  15      
Lys Met Ser Ala Leu Ala Gly Val Ala Gly Val Ser Gln Ala Val Gly 
            20                  25                  30          



<210> 43
<211> 45
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 43
Met Lys Thr Lys Ile Pro Asp Ala Val Leu Ala Ala Glu Val Ser Arg 
1               5                   10                  15      
Arg Gly Leu Val Lys Thr Thr Ala Ile Gly Gly Leu Ala Met Ala Ser 
            20                  25                  30          
Ser Ala Leu Thr Leu Pro Phe Ser Arg Ile Ala His Ala 
        35                  40                  45  

<210> 44
<211> 35
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 44
Met Ser Asn Phe Asn Gln Ile Ser Arg Arg Asp Phe Val Lys Ala Ser 
1               5                   10                  15      
Ser Ala Gly Ala Ala Leu Ala Val Ser Asn Leu Thr Leu Pro Phe Asn 
            20                  25                  30          
Val Met Ala 
        35  

<210> 45
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 45
Met Ser Ile Ser Arg Arg Ser Phe Leu Gln Gly Val Gly Ile Gly Cys 
1               5                   10                  15      
Ser Ala Cys Ala Leu Gly Ala Phe Pro Pro Gly Ala Leu Ala 
            20                  25                  30  

<210> 46
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 46
Met Lys Thr Val Leu Pro Ser Val Pro Glu Thr Val Arg Leu Ser Arg 
1               5                   10                  15      
Arg Gly Phe Leu Val Gln Ala Gly Thr Ile Thr Cys Ser Val Ala Phe 
            20                  25                  30          
Gly Ser Val Pro Ala 
        35          

<210> 47
<211> 44
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 47
Met Gly Arg Leu Asn Arg Phe Arg Leu Gly Lys Asp Gly Arg Arg Glu 
1               5                   10                  15      
Gln Ala Ser Leu Ser Arg Arg Gly Phe Leu Val Thr Ser Leu Gly Ala 
            20                  25                  30          
Gly Val Met Phe Gly Phe Ala Arg Pro Ser Ser Ala 
        35                  40                  

<210> 48
<211> 50
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 48
Met Ser Asp Lys Asp Ser Lys Asn Thr Pro Gln Val Pro Glu Lys Leu 
1               5                   10                  15      
Gly Leu Ser Arg Arg Gly Phe Leu Gly Ala Ser Ala Val Thr Gly Ala 
            20                  25                  30          
Ala Val Ala Ala Thr Ala Leu Gly Gly Ala Val Met Thr Arg Glu Ser 
        35                  40                  45              
Trp Ala 
    50  

<210> 49
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 49
Met Glu Ser Arg Thr Ser Arg Arg Thr Phe Val Lys Gly Leu Ala Ala 
1               5                   10                  15      
Ala Gly Val Leu Gly Gly Leu Gly Leu Trp Arg Ser Pro Ser Trp Ala 
            20                  25                  30          



<210> 50
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 50
Met Ser Leu Ser Arg Arg Gln Phe Ile Gln Ala Ser Gly Ile Ala Leu 
1               5                   10                  15      
Cys Ala Gly Ala Val Pro Leu Lys Ala Ser Ala 
            20                  25          

<210> 51
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 51
Met Thr Leu Asn Arg Arg Asp Phe Ile Lys Thr Ser Gly Ala Ala Val 
1               5                   10                  15      
Ala Ala Val Gly Ile Leu Gly Phe Pro His Leu Ala Phe Gly 
            20                  25                  30  

<210> 52
<211> 45
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide signal

<400> 52
Met Thr Asp Ser Arg Ala Asn Arg Ala Asp Ala Thr Arg Gly Val Ala 
1               5                   10                  15      
Ser Val Ser Arg Arg Arg Phe Leu Ala Gly Ala Gly Leu Thr Ala Gly 
            20                  25                  30          
Ala Ile Ala Leu Ser Ser Met Ser Thr Ser Ala Ser Ala 
        35                  40                  45  

<210> 53
<211> 337
<212> PRT
<213> Artificial Sequence

<220> 
<223> OPH

<400> 53
Met Ser Ile Gly Thr Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile 
1               5                   10                  15      
Thr Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly 
            20                  25                  30          
Ser Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg 
        35                  40                  45              
Lys Ala Leu Ala Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala 
    50                  55                  60                  
Ala Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg 
65                  70                  75                  80  
Asp Val Ser Leu Leu Ala Glu Val Ser Arg Ala Ala Asp Val His Ile 
                85                  90                  95      
Val Ala Ala Thr Gly Leu Trp Phe Asp Pro Pro Leu Ser Met Arg Leu 
            100                 105                 110         
Arg Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr 
        115                 120                 125             
Gly Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr 
    130                 135                 140                 
Thr Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Lys Ala Ala Ala 
145                 150                 155                 160 
Arg Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Ala Ala 
                165                 170                 175     
Ser Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly 
            180                 185                 190         
Leu Ser Pro Ser Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp 
        195                 200                 205             
Leu Ser Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu 
    210                 215                 220                 
Asp His Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala 
225                 230                 235                 240 
Ser Ala Leu Leu Gly Ile Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile 
                245                 250                 255     
Lys Ala Leu Ile Asp Gln Gly Tyr Met Lys Gln Ile Leu Val Ser Asn 
            260                 265                 270         
Asp Trp Leu Phe Gly Phe Ser Ser Tyr Val Thr Asn Ile Met Asp Val 
        275                 280                 285             
Met Asp Arg Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val 
    290                 295                 300                 
Ile Pro Phe Leu Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Gly 
305                 310                 315                 320 
Ile Thr Val Thr Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala 
                325                 330                 335     
Ser 
    

