                         SEQUENCE LISTING

<110>  SANOFI
 
<120>  NINJURIN-1 AS THERAPEUTIC TARGET FOR BRAIN TUMOR

<130>  FR2012-077

<160>  17    

<170>  PatentIn version 3.3

<210>  1
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Ser Gly Thr Glu Glu Tyr Glu Leu Asn Gly Gly Leu Pro Pro 
1               5                   10                  15      


Gly Thr Pro Gly Ser Pro Asp Ala Ser Pro Ala Arg Trp Gly Trp Arg 
            20                  25                  30          


His Gly Pro Ile Asn Val Asn His Tyr Ala Ser Lys Lys Ser Ala Ala 
        35                  40                  45              


Glu Ser Met Leu Asp Ile Ala Leu Leu Met Ala Asn Ala Ser Gln Leu 
    50                  55                  60                  


Lys Ala Val Val Glu Gln Gly Pro Ser Phe Ala Phe Tyr Val Pro Leu 
65                  70                  75                  80  


Val Val Leu Ile Ser Ile Ser Leu Val Leu Gln Ile Gly Val Gly Val 
                85                  90                  95      


Leu Leu Ile Phe Leu Val Lys Tyr Asp Leu Asn Asn Pro Ala Lys His 
            100                 105                 110         


Ala Lys Leu Asp Phe Leu Asn Asn Leu Ala Thr Gly Leu Val Phe Ile 
        115                 120                 125             


Ile Val Val Val Asn Ile Phe Ile Thr Ala Phe Gly Val Gln Lys Pro 
    130                 135                 140                 


Leu Met Asp Met Ala Pro Gln Gln 
145                 150         


<210>  2
<211>  1297
<212>  DNA
<213>  Artificial

<220>
<223>  cDNA sequence corresponding to the mRNA sequence encoding for 
       Ninjurin-1

<400>  2
cgcagctgga gcctgcggct gaggctcggg cgcgctcagg cccggatcct ggcggcctgg     60

gcggccgcac catggactcg ggaaccgagg agtacgagct caacggcggc ctgcctccgg    120

gcacacccgg ctccccggac gcctcgccgg cccgctgggg ctggaggcac gggcccatca    180

acgtgaacca ttacgccagc aagaagagcg cagccgagag catgctggac atcgcgctgc    240

tgatggccaa cgcgtcccag ctgaaggccg tcgtggaaca gggccccagc ttcgccttct    300

atgtgcccct ggtggtcctc atctccatct cccttgtgct gcagatcggc gtgggggtgc    360

tgctcatctt ccttgtcaag tacgacctta acaacccggc caagcacgcc aagctggact    420

tcctcaacaa cctggccacg ggcctggtgt tcatcatcgt ggtagtcaac atcttcatca    480

cggccttcgg ggtccagaag cccttgatgg acatggcacc ccagcagtag gacacccagg    540

accctggatg ctgcctgccc tgcaactcag ctgcccgacc ccaggagtcg ccatacctgt    600

gaggtgtcca cctccctgca catggcacta cccagactgc cagagcccag gctggcctca    660

tctgcaccat gtccccggac cagcccttgc tctgactgcg gccaagcacc acgcaggagg    720

ccactcttgt ctctcagcag ctgttcccag gaggcagctc cctcctggca catgggggct    780

ggccacaata gcccagaggg tcagaactgg acagctgcag agacctgtgc ccagagaagg    840

gtctcgaccc actcaaggac acacagcagg tccgtggatg ggctggatga gtgaccaggg    900

ccagcctctg tctcaggaca ttccagaagg acaaggagat gtctctccct ctcccaaagc    960

accagcgtcc ctgcctcccg tgggccctgt ccgggttgcc ctggtgaccc cagcctctgt   1020

ccacttccta acccagggac cctgcacagc cagaactgcc tttggcccta cggatggcca   1080

ctggctctgg tcttaagtgc ctgggcttgg tggccatcaa gagggagcca gtcaggcctg   1140

tgagggccgt agaccttgta tataccctgc accagcagtg accgggcaga gcccaacccc   1200

ctccacgggg gtcccagcac ccacttttct aatcatgaat gaacaataaa gcccacgctc   1260

tttgtcaggc tccacatgcc aaaaaaaaaa aaaaaaa                            1297


<210>  3
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  P1 peptide

<400>  3

Met Asp Pro Gly Thr Glu Glu Tyr Glu Leu Asn Gly Asp Leu Arg Pro 
1               5                   10                  15      


Gly Ser Pro Gly Ser Pro Asp Ala Ser Pro Pro Arg Trp Gly 
            20                  25                  30  


<210>  4
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  P2 peptide

<400>  4

Pro Gly Ser Pro Gly Ser Pro Asp Ala Ser Pro Pro Arg Trp Gly Leu 
1               5                   10                  15      


Arg Asn Arg Pro Ile Asn Val Asn His Tyr Ala Asn Lys Lys 
            20                  25                  30  


<210>  5
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  M3 peptide

<400>  5

Pro Pro Arg Trp Ala Leu Arg Asn Arg Pro Ile Asn 
1               5                   10          


<210>  6
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  M4 peptide

<400>  6

Pro Pro Arg Trp Gly Asn Arg Asn Arg Pro Ile Asn 
1               5                   10          


<210>  7
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  M6 peptide

<400>  7

Pro Pro Arg Trp Gly Leu Arg Leu Arg Pro Ile Asn 
1               5                   10          


<210>  8
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  P6 peptide

<400>  8

Pro Pro Arg Trp Gly Leu Arg Asn Arg Pro Ile Asn 
1               5                   10          


<210>  9
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  hP1 peptide

<400>  9

Met Asp Ser Gly Thr Glu Glu Tyr Glu Leu Asn Gly Gly Leu Pro Pro 
1               5                   10                  15      


Gly Thr Pro Gly Ser Pro Asp Ala Ser Pro Ala Arg Trp Gly 
            20                  25                  30  


<210>  10
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  hP2 peptide

<400>  10

Pro Gly Thr Pro Gly Ser Pro Asp Ala Ser Pro Ala Arg Trp Gly Trp 
1               5                   10                  15      


Arg His Gly Pro Ile Asn Val Asn His Tyr Ala Ser Lys Lys 
            20                  25                  30  


<210>  11
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  hM3 peptide

<400>  11

Pro Ala Arg Trp Ala Trp Arg His Gly Pro Ile Asn 
1               5                   10          


<210>  12
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  hM4 peptide

<400>  12

Pro Ala Arg Trp Gly Asn Arg His Gly Pro Ile Asn 
1               5                   10          


<210>  13
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  hM6 peptide

<400>  13

Pro Ala Arg Trp Gly Trp Arg Leu Gly Pro Ile Asn 
1               5                   10          


<210>  14
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  hP6 peptide

<400>  14

Pro Ala Arg Trp Gly Trp Arg His Gly Pro Ile Asn 
1               5                   10          


<210>  15
<211>  152
<212>  PRT
<213>  Rattus norvegicus

<400>  15

Met Asp Pro Gly Thr Glu Glu Tyr Glu Leu Asn Gly Asp Leu Arg Pro 
1               5                   10                  15      


Gly Ser Pro Gly Ser Pro Asp Ala Ser Pro Pro Arg Trp Gly Leu Arg 
            20                  25                  30          


Asn Arg Pro Ile Asn Val Asn His Tyr Ala Asn Lys Lys Ser Ala Ala 
        35                  40                  45              


Glu Ser Met Leu Asp Ile Ala Leu Leu Met Ala Asn Ala Ser Gln Leu 
    50                  55                  60                  


Lys Ala Val Val Glu Gln Gly Asn Glu Phe Ala Phe Phe Val Pro Leu 
65                  70                  75                  80  


Val Val Leu Ile Ser Ile Ser Leu Val Leu Gln Ile Gly Val Gly Val 
                85                  90                  95      


Leu Leu Ile Phe Leu Val Lys Tyr Asp Leu Asn Asn Pro Ala Lys His 
            100                 105                 110         


Ala Lys Leu Asp Phe Leu Asn Asn Leu Ala Thr Gly Leu Val Phe Ile 
        115                 120                 125             


Ile Val Val Val Asn Ile Phe Ile Thr Ala Phe Gly Val Gln Lys Pro 
    130                 135                 140                 


Val Met Asp Val Ala Pro Arg Gln 
145                 150         


<210>  16
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  P4 control peptide

<400>  16

Ser Ala Ala Glu Ser Met Leu Asp Ile Ala Leu Leu Met Ala Asn Ala 
1               5                   10                  15      


Ser Gln Leu Lys Ala Val Val Glu Gln Gly Asn Glu Phe Ala 
            20                  25                  30  


<210>  17
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  hP4 control peptide

<400>  17

Ser Ala Ala Glu Ser Met Leu Asp Ile Ala Leu Leu Met Ala Asn Ala 
1               5                   10                  15      


Ser Gln Leu Lys Ala Val Val Glu Gln Gly Pro Ser Phe Ala 
            20                  25                  30  


