                         SEQUENCE LISTING

<110>  UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
       Stice, Steven L.
       Peroni, John F.
       Mumaw, Jennifer
 
<120>  OSSIFICATION-INDUCING COMPOSITIONS AND METHODS OF USE THEREOF

<130>  G25-148PCT

<150>  US 61/736,764
<151>  2012-12-13

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  3150
<212>  DNA
<213>  Homo sapiens

<400>  1
ccacaaaggg cacttggccc cagggctagg agagcgaggg gagagcacag ccacccgcct       60

cggcggcccg ggactcggct cgactcgccg gagaatgcgc ccgaggacga cggggcgcca      120

gagccgcggt gctttcaact ggcgagcgcg aatgggggtg cactggagta aggcagagtg      180

atgcgggggg gcaactcgcc tggcaccgag atcgccgccg tgcccttccc tggacccggc      240

gtcgcccagg atggctgccc cgagccatgg gccgcggcgg agctagcgcg gagcgcccga      300

ccctcgaccc ccgagtcccg gagccggccc cgcgcggggc cacgcgtccc tcgggcgctg      360

gttcctaagg aggacgacag caccagcttc tcctttctcc cttcccttcc ctgccccgca      420

ctcctccccc tgctcgctgt tgttgtgtgt cagcacttgg ctggggactt cttgaacttg      480

cagggagaat aacttgcgca ccccactttg cgccggtgcc tttgccccag cggagcctgc      540

ttcgccatct ccgagcccca ccgcccctcc actcctcggc cttgcccgac actgagacgc      600

tgttcccagc gtgaaaagag agactgcgcg gccggcaccc gggagaagga ggaggcaaag      660

aaaaggaacg gacattcggt ccttgcgcca ggtcctttga ccagagtttt tccatgtgga      720

cgctctttca atggacgtgt ccccgcgtgc ttcttagacg gactgcggtc tcctaaaggt      780

cgaccatggt ggccgggacc cgctgtcttc tagcgttgct gcttccccag gtcctcctgg      840

gcggcgcggc tggcctcgtt ccggagctgg gccgcaggaa gttcgcggcg gcgtcgtcgg      900

gccgcccctc atcccagccc tctgacgagg tcctgagcga gttcgagttg cggctgctca      960

gcatgttcgg cctgaaacag agacccaccc ccagcaggga cgccgtggtg cccccctaca     1020

tgctagacct gtatcgcagg cactcaggtc agccgggctc acccgcccca gaccaccggt     1080

tggagagggc agccagccga gccaacactg tgcgcagctt ccaccatgaa gaatctttgg     1140

aagaactacc agaaacgagt gggaaaacaa cccggagatt cttctttaat ttaagttcta     1200

tccccacgga ggagtttatc acctcagcag agcttcaggt tttccgagaa cagatgcaag     1260

atgctttagg aaacaatagc agtttccatc accgaattaa tatttatgaa atcataaaac     1320

ctgcaacagc caactcgaaa ttccccgtga ccagactttt ggacaccagg ttggtgaatc     1380

agaatgcaag caggtgggaa agttttgatg tcacccccgc tgtgatgcgg tggactgcac     1440

agggacacgc caaccatgga ttcgtggtgg aagtggccca cttggaggag aaacaaggtg     1500

tctccaagag acatgttagg ataagcaggt ctttgcacca agatgaacac agctggtcac     1560

agataaggcc attgctagta acttttggcc atgatggaaa agggcatcct ctccacaaaa     1620

gagaaaaacg tcaagccaaa cacaaacagc ggaaacgcct taagtccagc tgtaagagac     1680

accctttgta cgtggacttc agtgacgtgg ggtggaatga ctggattgtg gctcccccgg     1740

ggtatcacgc cttttactgc cacggagaat gcccttttcc tctggctgat catctgaact     1800

ccactaatca tgccattgtt cagacgttgg tcaactctgt taactctaag attcctaagg     1860

catgctgtgt cccgacagaa ctcagtgcta tctcgatgct gtaccttgac gagaatgaaa     1920

aggttgtatt aaagaactat caggacatgg ttgtggaggg ttgtgggtgt cgctagtaca     1980

gcaaaattaa atacataaat atatatatat atatatattt tagaaaaaag aaaaaaacaa     2040

acaaacaaaa aaaccccacc ccagttgaca ctttaatatt tcccaatgaa gactttattt     2100

atggaatgga atggaaaaaa aaacagctat tttgaaaata tatttatatc tacgaaaaga     2160

agttgggaaa acaaatattt taatcagaga attattcctt aaagatttaa aatgtattta     2220

gttgtacatt ttatatgggt tcaaccccag cacatgaagt ataatggtca gatttatttt     2280

gtatttattt actattataa ccacttttta ggaaaaaaat agctaatttg tatttatatg     2340

taatcaaaag aagtatcggg tttgtacata attttccaaa aattgtagtt gttttcagtt     2400

gtgtgtattt aagatgaaaa gtctacatgg aaggttactc tggcaaagtg cttagcacgt     2460

ttgctttttt gcagtgctac tgttgagttc acaagttcaa gtccagaaaa aaaaagtgga     2520

taatccactc tgctgacttt caagattatt atattattca attctcagga atgttgcaga     2580

gtgattgtcc aatccatgag aatttacatc cttattaggt ggaatatttg gataagaacc     2640

agacattgct gatctattat agaaactctc ctcctgcccc ttaatttaca gaaagaataa     2700

agcaggatcc atagaaataa ttaggaaaac gatgaacctg caggaaagtg aatgatggtt     2760

tgttgttctt ctttcctaaa ttagtgatcc cttcaaaggg gctgatctgg ccaaagtatt     2820

caataaaacg taagatttct tcattattga tattgtggtc atatatattt aaaattgata     2880

tctcgtggcc ctcatcaagg gttggaaatt tatttgtgtt ttacctttac ctcatctgag     2940

agctctttat tctccaaaga acccagtttt ctaacttttt gcccaacacg cagcaaaatt     3000

atgcacatcg tgttttctgc ccaccctctg ttctctgacc tatcagcttg cttttctttc     3060

caaggttgtg tgtttgaaca catttctcca aatgttaaac ctatttcaga taataaatat     3120

caaatctctg gcatttcatt ctataaagtc                                      3150


<210>  2
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Ala Gly Thr Arg Cys Leu Leu Ala Leu Leu Leu Pro Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ala Gly Leu Val Pro Glu Leu Gly Arg Arg Lys 
            20                  25                  30          


Phe Ala Ala Ala Ser Ser Gly Arg Pro Ser Ser Gln Pro Ser Asp Glu 
        35                  40                  45              


Val Leu Ser Glu Phe Glu Leu Arg Leu Leu Ser Met Phe Gly Leu Lys 
    50                  55                  60                  


Gln Arg Pro Thr Pro Ser Arg Asp Ala Val Val Pro Pro Tyr Met Leu 
65                  70                  75                  80  


Asp Leu Tyr Arg Arg His Ser Gly Gln Pro Gly Ser Pro Ala Pro Asp 
                85                  90                  95      


His Arg Leu Glu Arg Ala Ala Ser Arg Ala Asn Thr Val Arg Ser Phe 
            100                 105                 110         


His His Glu Glu Ser Leu Glu Glu Leu Pro Glu Thr Ser Gly Lys Thr 
        115                 120                 125             


Thr Arg Arg Phe Phe Phe Asn Leu Ser Ser Ile Pro Thr Glu Glu Phe 
    130                 135                 140                 


Ile Thr Ser Ala Glu Leu Gln Val Phe Arg Glu Gln Met Gln Asp Ala 
145                 150                 155                 160 


Leu Gly Asn Asn Ser Ser Phe His His Arg Ile Asn Ile Tyr Glu Ile 
                165                 170                 175     


Ile Lys Pro Ala Thr Ala Asn Ser Lys Phe Pro Val Thr Arg Leu Leu 
            180                 185                 190         


Asp Thr Arg Leu Val Asn Gln Asn Ala Ser Arg Trp Glu Ser Phe Asp 
        195                 200                 205             


Val Thr Pro Ala Val Met Arg Trp Thr Ala Gln Gly His Ala Asn His 
    210                 215                 220                 


Gly Phe Val Val Glu Val Ala His Leu Glu Glu Lys Gln Gly Val Ser 
225                 230                 235                 240 


Lys Arg His Val Arg Ile Ser Arg Ser Leu His Gln Asp Glu His Ser 
                245                 250                 255     


Trp Ser Gln Ile Arg Pro Leu Leu Val Thr Phe Gly His Asp Gly Lys 
            260                 265                 270         


Gly His Pro Leu His Lys Arg Glu Lys Arg Gln Ala Lys His Lys Gln 
        275                 280                 285             


Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp 
    290                 295                 300                 


Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr 
305                 310                 315                 320 


His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His 
                325                 330                 335     


Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val 
            340                 345                 350         


Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala 
        355                 360                 365             


Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn 
    370                 375                 380                 


Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
385                 390                 395     


<210>  3
<211>  4049
<212>  DNA
<213>  Homo sapiens

<400>  3
agcgcgtacc actctggcgc tcccgaggcg gcctcttgtg cgatccaggg cgcacaaggc       60

tgggagagcg ccccggggcc cctgctatcc gcgccggagg ttggaagagg gtgggttgcc      120

gccgcccgag ggcgagagcg ccagaggagc gggaagaagg agcgctcgcc cgcccgcctg      180

cctcctcgct gcctccccgg cgttggctct ctggactcct aggcttgctg gctgctcctc      240

ccacccgcgc ccgcctcctc actcgccttt tcgttcgccg gggctgcttt ccaagccctg      300

cggtgcgccc gggcgagtgc ggggcgaggg gcccggggcc agcaccgagc agggggcggg      360

ggtccgggca gagcgcggcc ggccggggag gggccatgtc tggcgcgggc gcagcggggc      420

ccgtctgcag caagtgaccg agcggcgcgg acggccgcct gccccctctg ccacctgggg      480

cggtgcgggc ccggagcccg gagcccgggt agcgcgtaga gccggcgcga tgcacgtgcg      540

ctcactgcga gctgcggcgc cgcacagctt cgtggcgctc tgggcacccc tgttcctgct      600

gcgctccgcc ctggccgact tcagcctgga caacgaggtg cactcgagct tcatccaccg      660

gcgcctccgc agccaggagc ggcgggagat gcagcgcgag atcctctcca ttttgggctt      720

gccccaccgc ccgcgcccgc acctccaggg caagcacaac tcggcaccca tgttcatgct      780

ggacctgtac aacgccatgg cggtggagga gggcggcggg cccggcggcc agggcttctc      840

ctacccctac aaggccgtct tcagtaccca gggcccccct ctggccagcc tgcaagatag      900

ccatttcctc accgacgccg acatggtcat gagcttcgtc aacctcgtgg aacatgacaa      960

ggaattcttc cacccacgct accaccatcg agagttccgg tttgatcttt ccaagatccc     1020

agaaggggaa gctgtcacgg cagccgaatt ccggatctac aaggactaca tccgggaacg     1080

cttcgacaat gagacgttcc ggatcagcgt ttatcaggtg ctccaggagc acttgggcag     1140

ggaatcggat ctcttcctgc tcgacagccg taccctctgg gcctcggagg agggctggct     1200

ggtgtttgac atcacagcca ccagcaacca ctgggtggtc aatccgcggc acaacctggg     1260

cctgcagctc tcggtggaga cgctggatgg gcagagcatc aaccccaagt tggcgggcct     1320

gattgggcgg cacgggcccc agaacaagca gcccttcatg gtggctttct tcaaggccac     1380

ggaggtccac ttccgcagca tccggtccac ggggagcaaa cagcgcagcc agaaccgctc     1440

caagacgccc aagaaccagg aagccctgcg gatggccaac gtggcagaga acagcagcag     1500

cgaccagagg caggcctgta agaagcacga gctgtatgtc agcttccgag acctgggctg     1560

gcaggactgg atcatcgcgc ctgaaggcta cgccgcctac tactgtgagg gggagtgtgc     1620

cttccctctg aactcctaca tgaacgccac caaccacgcc atcgtgcaga cgctggtcca     1680

cttcatcaac ccggaaacgg tgcccaagcc ctgctgtgcg cccacgcagc tcaatgccat     1740

ctccgtcctc tacttcgatg acagctccaa cgtcatcctg aagaaataca gaaacatggt     1800

ggtccgggcc tgtggctgcc actagctcct ccgagaattc agaccctttg gggccaagtt     1860

tttctggatc ctccattgct cgccttggcc aggaaccagc agaccaactg ccttttgtga     1920

gaccttcccc tccctatccc caactttaaa ggtgtgagag tattaggaaa catgagcagc     1980

atatggcttt tgatcagttt ttcagtggca gcatccaatg aacaagatcc tacaagctgt     2040

gcaggcaaaa cctagcagga aaaaaaaaca acgcataaag aaaaatggcc gggccaggtc     2100

attggctggg aagtctcagc catgcacgga ctcgtttcca gaggtaatta tgagcgccta     2160

ccagccaggc cacccagccg tgggaggaag ggggcgtggc aaggggtggg cacattggtg     2220

tctgtgcgaa aggaaaattg acccggaagt tcctgtaata aatgtcacaa taaaacgaat     2280

gaatgaaaat ggttaggacg ttacagatat attttcctaa acaatttatc cccatttctc     2340

ggtttatcct gatgcgtaaa cagaagctgt gtcaagtgga gggcggggag gtccctctcc     2400

attccctaca gttttcatcc tgaggcttgc agaggcccag tgtttaccga ggtttgccca     2460

aatccaagat ctagtgggag gggaaagagc aaatgtctgc tccgaggagg gcggtgtgtt     2520

gatctttgga ggaaaaatat gttctgttgt tcagctggat ttgccgtggc agaaatgaaa     2580

ctaggtgtgt gaaatacccg cagacatttg ggattggctt ttcacctcgc cccagtggta     2640

gtaaatccat gtgaaattgc agaggggaca aggacagcaa gtaggatgga acttgcaact     2700

caaccctgtt gttaagaagc accaatgggc cgggcacagt agctcccacc tgtaatccca     2760

gcactttggg aggctgaggt gggcggatca tttgaggtca ggagttcgag accagcctgg     2820

ccaacatggt gaaaccccat ctctactaaa aatacaaaaa ttagccgggc atggtggcac     2880

gcacctgtaa tcccagctac tctggaggct gaggcaggag aattgcttga accccagagg     2940

tggaggttgc agtgagccaa gatcgtccca ctgcactcca gcttgggtga caaaacaaga     3000

ctccatctca aaagaaaaaa aaaacagcac caatgaagcc tagttctcca cgggagtggg     3060

gtgagcagga gcactgcaca tcgccccagt ggaccctctg gtctttgtct gcagtggcat     3120

tccaaggctg ggccctggca agggcacccg tggctgtctc ttcatttgca gaccctgatc     3180

agaagtctct gcaaacaaat ttgctccttg aattaagggg gagatggcat aataggaggt     3240

ctgatgggtg caggatgtgc tggacttaca ttgcaaatag aagccttgtt gagggtgaca     3300

tcctaaccaa gtgtcccgat ttggaggtgg catttctgac gtggctcttg gtgtaagcct     3360

gccttgcctt ggctggtgag tcccataaat agtatgcact cagcctccgg ccacaaacac     3420

aaggcctagg ggagggctag actgtctgca aacgttttct gcatctgtaa agaaaacaag     3480

gtgatcgaaa actgtggcca tgtggaaccc ggtcttgtgg gggactgttt ctccatcttg     3540

actcagacag ttcctggaaa caccggggct ctgtttttat tttctttgat gtttttcttc     3600

tttagtagct tgggctgcag cctccactct ctagtcactg gggaggagta ttttttgtta     3660

tgtttggttt catttgctgg cagagctggg gctttttgtg tgatccctct tggtgtgagt     3720

tttctgaccc aaccagcctc tggttagcat catttgtaca tttaaacctg taaatagttg     3780

ttacaaagca aagagattat ttatttccat ccaaagctct tttgaacacc cccccccctt     3840

taatccctcg ttcaggacga tgagcttgct ttccttcaac ctgtttgttt tcttatttaa     3900

gactatttat taatggttgg accaatgtac tcacagctgt tgcgtcgagc agtccttagt     3960

gaaaattctg tataaataga caaaatgaaa agggtttgac cttgcaataa aaggagacgt     4020

ttggttctgg caaaaaaaaa aaaaaaaaa                                       4049


<210>  4
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  4

Met His Val Arg Ser Leu Arg Ala Ala Ala Pro His Ser Phe Val Ala 
1               5                   10                  15      


Leu Trp Ala Pro Leu Phe Leu Leu Arg Ser Ala Leu Ala Asp Phe Ser 
            20                  25                  30          


Leu Asp Asn Glu Val His Ser Ser Phe Ile His Arg Arg Leu Arg Ser 
        35                  40                  45              


Gln Glu Arg Arg Glu Met Gln Arg Glu Ile Leu Ser Ile Leu Gly Leu 
    50                  55                  60                  


Pro His Arg Pro Arg Pro His Leu Gln Gly Lys His Asn Ser Ala Pro 
65                  70                  75                  80  


Met Phe Met Leu Asp Leu Tyr Asn Ala Met Ala Val Glu Glu Gly Gly 
                85                  90                  95      


Gly Pro Gly Gly Gln Gly Phe Ser Tyr Pro Tyr Lys Ala Val Phe Ser 
            100                 105                 110         


Thr Gln Gly Pro Pro Leu Ala Ser Leu Gln Asp Ser His Phe Leu Thr 
        115                 120                 125             


Asp Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu His Asp Lys 
    130                 135                 140                 


Glu Phe Phe His Pro Arg Tyr His His Arg Glu Phe Arg Phe Asp Leu 
145                 150                 155                 160 


Ser Lys Ile Pro Glu Gly Glu Ala Val Thr Ala Ala Glu Phe Arg Ile 
                165                 170                 175     


Tyr Lys Asp Tyr Ile Arg Glu Arg Phe Asp Asn Glu Thr Phe Arg Ile 
            180                 185                 190         


Ser Val Tyr Gln Val Leu Gln Glu His Leu Gly Arg Glu Ser Asp Leu 
        195                 200                 205             


Phe Leu Leu Asp Ser Arg Thr Leu Trp Ala Ser Glu Glu Gly Trp Leu 
    210                 215                 220                 


Val Phe Asp Ile Thr Ala Thr Ser Asn His Trp Val Val Asn Pro Arg 
225                 230                 235                 240 


His Asn Leu Gly Leu Gln Leu Ser Val Glu Thr Leu Asp Gly Gln Ser 
                245                 250                 255     


Ile Asn Pro Lys Leu Ala Gly Leu Ile Gly Arg His Gly Pro Gln Asn 
            260                 265                 270         


Lys Gln Pro Phe Met Val Ala Phe Phe Lys Ala Thr Glu Val His Phe 
        275                 280                 285             


Arg Ser Ile Arg Ser Thr Gly Ser Lys Gln Arg Ser Gln Asn Arg Ser 
    290                 295                 300                 


Lys Thr Pro Lys Asn Gln Glu Ala Leu Arg Met Ala Asn Val Ala Glu 
305                 310                 315                 320 


Asn Ser Ser Ser Asp Gln Arg Gln Ala Cys Lys Lys His Glu Leu Tyr 
                325                 330                 335     


Val Ser Phe Arg Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu 
            340                 345                 350         


Gly Tyr Ala Ala Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asn 
        355                 360                 365             


Ser Tyr Met Asn Ala Thr Asn His Ala Ile Val Gln Thr Leu Val His 
    370                 375                 380                 


Phe Ile Asn Pro Glu Thr Val Pro Lys Pro Cys Cys Ala Pro Thr Gln 
385                 390                 395                 400 


Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile 
                405                 410                 415     


Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys His 
            420                 425                 430     


<210>  5
<211>  1188
<212>  DNA
<213>  Canis familiaris

<400>  5
atggtggccg ggacccgctg tcttctagcg ttgctgcttc cccaggtcct cctgggcggc       60

gcggccggtc tcattacgga gctgggccgg aggaagttcg cggcatctcc tggccgctcc      120

ccgtcccagc cctcggacga agtcctgagc gagttcgagt tgcggctgct cagcatgttc      180

ggcctgaagc ggagacccac ccccagcagg gacgccgtgg tgccccccta catgctggac      240

ctgtaccgcc ggcactcggg ccagccgggc gcaccggccc cggaccaccg gctggagagg      300

gcagccagcc tggccaacac cgtgcgcagc ttccaccacg aagaatcttt ggaagaactg      360

ccagaaatga gtgggaaaac aacccggaga ttcttcttta atttaacttc tatccccact      420

gacgagttta tcacctcagc agaacttcag gtttttcggg aacagatgca ggaacctttg      480

gaaaacgata gcaatttcca tcaccgaatt aatatttatg aaattataaa acctgcagca      540

gccaacttga agttccccgt gaccagactt ttggacacca ggttggtgaa tcagaacgca      600

agcaggtggg agagctttga tgtcacccct gctgtgatga ggtggacggc acaggggctt      660

gccaaccacg gatttgtggt ggaagtgacc cacttggagg agaatcaagg tgtctccaag      720

agacacgtca ggattagcag gtctttgcac caagacgagc acagctggtc acaaatcagg      780

ccactgctag taacgtttgg ccacgatggg aaaggacacc ccctccacaa aagagaaaag      840

cgtcaagcaa aacacaaaca gcgcaaacgc cttaagtcca gctgtaagag acaccctttg      900

tacgtggact tcagtgacgt ggggtggaat gactggatcg tagctccccc ggggtaccac      960

gccttttatt gccatgggga atgccccttt cccctggcag atcacctgaa ctccactaac     1020

cacgccattg ttcagacgtt ggtcaactcg gttaattcta agatccccaa ggcgtgctgt     1080

gtaccaacag aactcagtgc tatctccatg ctgtaccttg atgaaaacga aaaggttgta     1140

ttaaagaact atcaggacat ggttgtggag ggttgtgggt gtcgttag                  1188


<210>  6
<211>  395
<212>  PRT
<213>  Canis familiaris

<400>  6

Met Val Ala Gly Thr Arg Cys Leu Leu Ala Leu Leu Leu Pro Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ala Gly Leu Ile Thr Glu Leu Gly Arg Arg Lys 
            20                  25                  30          


Phe Ala Ala Ser Pro Gly Arg Ser Pro Ser Gln Pro Ser Asp Glu Val 
        35                  40                  45              


Leu Ser Glu Phe Glu Leu Arg Leu Leu Ser Met Phe Gly Leu Lys Arg 
    50                  55                  60                  


Arg Pro Thr Pro Ser Arg Asp Ala Val Val Pro Pro Tyr Met Leu Asp 
65                  70                  75                  80  


Leu Tyr Arg Arg His Ser Gly Gln Pro Gly Ala Pro Ala Pro Asp His 
                85                  90                  95      


Arg Leu Glu Arg Ala Ala Ser Leu Ala Asn Thr Val Arg Ser Phe His 
            100                 105                 110         


His Glu Glu Ser Leu Glu Glu Leu Pro Glu Met Ser Gly Lys Thr Thr 
        115                 120                 125             


Arg Arg Phe Phe Phe Asn Leu Thr Ser Ile Pro Thr Asp Glu Phe Ile 
    130                 135                 140                 


Thr Ser Ala Glu Leu Gln Val Phe Arg Glu Gln Met Gln Glu Pro Leu 
145                 150                 155                 160 


Glu Asn Asp Ser Asn Phe His His Arg Ile Asn Ile Tyr Glu Ile Ile 
                165                 170                 175     


Lys Pro Ala Ala Ala Asn Leu Lys Phe Pro Val Thr Arg Leu Leu Asp 
            180                 185                 190         


Thr Arg Leu Val Asn Gln Asn Ala Ser Arg Trp Glu Ser Phe Asp Val 
        195                 200                 205             


Thr Pro Ala Val Met Arg Trp Thr Ala Gln Gly Leu Ala Asn His Gly 
    210                 215                 220                 


Phe Val Val Glu Val Thr His Leu Glu Glu Asn Gln Gly Val Ser Lys 
225                 230                 235                 240 


Arg His Val Arg Ile Ser Arg Ser Leu His Gln Asp Glu His Ser Trp 
                245                 250                 255     


Ser Gln Ile Arg Pro Leu Leu Val Thr Phe Gly His Asp Gly Lys Gly 
            260                 265                 270         


His Pro Leu His Lys Arg Glu Lys Arg Gln Ala Lys His Lys Gln Arg 
        275                 280                 285             


Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp Phe 
    290                 295                 300                 


Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr His 
305                 310                 315                 320 


Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His Leu 
                325                 330                 335     


Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn 
            340                 345                 350         


Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile 
        355                 360                 365             


Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn Tyr 
    370                 375                 380                 


Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
385                 390                 395 


<210>  7
<211>  7836
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lentiviral Vector pR-EF1-BMP2

<400>  7
caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac       60

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa      120

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat      180

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc      240

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga      300

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg      360

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc      420

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag      480

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc      540

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg      600

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg      660

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac      720

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac      780

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg      840

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg      900

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg      960

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     1020

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     1080

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     1140

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     1200

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     1260

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt     1320

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     1380

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     1440

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     1500

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     1560

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     1620

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     1680

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     1740

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     1800

ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct     1860

ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg     1920

aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt     1980

aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta     2040

atgtgagtta gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta     2100

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt     2160

acgccaagcg cgcaattaac cctcactaaa gggaacaaaa gctggagctg caagcttaat     2220

gtagtcttat gcaatactct tgtagtcttg caacatggta acgatgagtt agcaacatgc     2280

cttacaagga gagaaaaagc accgtgcatg ccgattggtg gaagtaaggt ggtacgatcg     2340

tgccttatta ggaaggcaac agacgggtct gacatggatt ggacgaacca ctgaattgcc     2400

gcattgcaga gatattgtat ttaagtgcct agctcgatac ataaacgggt ctctctggtt     2460

agaccagatc tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca     2520

ataaagcttg ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa     2580

ctagagatcc ctcagaccct tttagtcagt gtggaaaatc tctagcagtg gcgcccgaac     2640

agggacttga aagcgaaagg gaaaccagag gagctctctc gacgcaggac tcggcttgct     2700

gaagcgcgca cggcaagagg cgaggggcgg cgactggtga gtacgccaaa aattttgact     2760

agcggaggct agaaggagag agatgggtgc gagagcgtca gtattaagcg ggggagaatt     2820

agatcgcgat gggaaaaaat tcggttaagg ccagggggaa agaaaaaata taaattaaaa     2880

catatagtat gggcaagcag ggagctagaa cgattcgcag ttaatcctgg cctgttagaa     2940

acatcagaag gctgtagaca aatactggga cagctacaac catcccttca gacaggatca     3000

gaagaactta gatcattata taatacagta gcaaccctct attgtgtgca tcaaaggata     3060

gagataaaag acaccaagga agctttagac aagatagagg aagagcaaaa caaaagtaag     3120

accaccgcac agcaagcggc cgctgatctt cagacctgga ggaggagata tgagggacaa     3180

ttggagaagt gaattatata aatataaagt agtaaaaatt gaaccattag gagtagcacc     3240

caccaaggca aagagaagag tggtgcagag agaaaaaaga gcagtgggaa taggagcttt     3300

gttccttggg ttcttgggag cagcaggaag cactatgggc gcagcctcaa tgacgctgac     3360

ggtacaggcc agacaattat tgtctggtat agtgcagcag cagaacaatt tgctgagggc     3420

tattgaggcg caacagcatc tgttgcaact cacagtctgg ggcatcaagc agctccaggc     3480

aagaatcctg gctgtggaaa gatacctaaa ggatcaacag ctcctgggga tttggggttg     3540

ctctggaaaa ctcatttgca ccactgctgt gccttggaat gctagttgga gtaataaatc     3600

tctggaacag attggaatca cacgacctgg atggagtggg acagagaaat taacaattac     3660

acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa gaatgaacaa     3720

gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat aacaaattgg     3780

ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt aagaatagtt     3840

tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt atcgtttcag     3900

acccacctcc caaccccgag gggacccgac aggcccgaag gaatagaaga agaaggtgga     3960

gagagagaca gagacagatc cattcgatta gtgaacggat ctcgacggta tcggttttaa     4020

aagaaaaggg gggattgggg ggtacagtgc aggggaaaga atagtagaca taatagcaac     4080

agacatacaa actaaagaat tacaaaaaca aattacaaaa attcaaaatt ttatcgatgg     4140

atctgcgatc gctccggtgc ccgtcagtgg gcagagcgca catcgcccac agtccccgag     4200

aagttggggg gaggggtcgg caattgaacg ggtgcctaga gaaggtggcg cggggtaaac     4260

tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg agggtggggg agaaccgtat     4320

ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc cagaacacag     4380

ctgaagcttc gaggggctcg catctctcct tcacgcgccc gccgccctac ctgaggccgc     4440

catccacgcc ggttgagtcg cgttctgccg cctcccgcct gtggtgcctc ctgaactgcg     4500

tccgccgtct aggtaagttt aaagctcagg tcgagaccgg gcctttgtcc ggcgctccct     4560

tggagcctac ctagactcag ccggctctcc acgctttgcc tgaccctgct tgctcaactc     4620

tacgtctttg tttcgttttc tgttctgcgc cgttacagat ccaagctgtg accggcgcct     4680

actctagagc caccatggtg gccgggaccc gctgtcttct agcgttgctg cttccccagg     4740

tcctcctggg cggcgcggct ggcctcgttc cggagctggg ccgcaggaag ttcgcggcgg     4800

cgtcgtcggg ccgcccctca tcccagccct ctgacgaggt cctgagcgag ttcgagttgc     4860

ggctgctcag catgttcggc ctgaaacaga gacccacccc cagcagggac gccgtggtgc     4920

ccccctacat gctagacctg tatcgcaggc actcaggtca gccgggctca cccgccccag     4980

accaccggtt ggagagggca gccagccgag ccaacactgt gcgcagcttc caccatgaag     5040

aatctttgga agaactacca gaaacgagtg ggaaaacaac ccggagattc ttctttaatt     5100

taagttctat ccccacggag gagtttatca cctcagcaga gcttcaggtt ttccgagaac     5160

agatgcaaga tgctttagga aacaatagca gtttccatca ccgaattaat atttatgaaa     5220

tcataaaacc tgcaacagcc aactcgaaat tccccgtgac cagacttttg gacaccaggt     5280

tggtgaatca gaatgcaagc aggtgggaaa gttttgatgt cacccccgct gtgatgcggt     5340

ggactgcaca gggacacgcc aaccatggat tcgtggtgga agtggcccac ttggaggaga     5400

aacaaggtgt ctccaagaga catgttagga taagcaggtc tttgcaccaa gatgaacaca     5460

gctggtcaca gataaggcca ttgctagtaa cttttggcca tgatggaaaa gggcatcctc     5520

tccacaaaag agaaaaacgt caagccaaac acaaacagcg gaaacgcctt aagtccagct     5580

gtaagagaca ccctttgtac gtggacttca gtgacgtggg gtggaatgac tggattgtgg     5640

ctcccccggg gtatcacgcc ttttactgcc acggagaatg cccttttcct ctggctgatc     5700

atctgaactc cactaatcat gccattgttc agacgttggt caactctgtt aactctaaga     5760

ttcctaaggc atgctgtgtc ccgacagaac tcagtgctat ctcgatgctg taccttgacg     5820

agaatgaaaa ggttgtatta aagaactatc aggacatggt tgtggagggt tgtgggtgtc     5880

gctaggtcga caatcaacct ctggattaca aaatttgtga aagattgact ggtattctta     5940

actatgttgc tccttttacg ctatgtggat acgctgcttt aatgcctttg tatcatgcta     6000

ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggttg ctgtctcttt     6060

atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg tttgctgacg     6120

caacccccac tggttggggc attgccacca cctgtcagct cctttccggg actttcgctt     6180

tccccctccc tattgccacg gcggaactca tcgccgcctg ccttgcccgc tgctggacag     6240

gggctcggct gttgggcact gacaattccg tggtgttgtc ggggaagctg acgtcctttc     6300

catggctgct cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc tgctacgtcc     6360

cttcggccct caatccagcg gaccttcctt cccgcggcct gctgccggct ctgcggcctc     6420

ttccgcgtct tcgccttcgc cctcagacga gtcggatctc cctttgggcc gcctccccgc     6480

ctggaattcg agctcggtac ctttaagacc aatgacttac aaggcagctg tagatcttag     6540

ccacttttta aaagaaaagg ggggacttgg aagggctaat tcactcccaa cgaagacaag     6600

atctgctttt tgcttgtact gggtctctct ggttagacca gatctgagcc tgggagctct     6660

ctggctaact agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgcttcaag     6720

tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt     6780

cagtgtggaa aatctctagc agtagtagtt catgtcatct tattattcag tatttataac     6840

ttgcaaagaa atgaatatca gagagtgaga ggaacttgtt tattgcagct tataatggtt     6900

acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta     6960

gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggctctag ctatcccgcc     7020

cctaactccg cccatcccgc ccctaactcc gcccagttcc gcccattctc cgccccatgg     7080

ctgactaatt ttttttattt atgcagaggc cgaggccgcc tcggcctctg agctattcca     7140

gaagtagtga ggaggctttt ttggaggcct agggacgtac ccaattcgcc ctatagtgag     7200

tcgtattacg cgcgctcact ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc     7260

gttacccaac ttaatcgcct tgcagcacat ccccctttcg ccagctggcg taatagcgaa     7320

gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga atggcgcgac     7380

gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct     7440

acacttgcca gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg     7500

ttcgccggct ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt     7560

gctttacggc acctcgaccc caaaaaactt gattagggtg atggttcacg tagtgggcca     7620

tcgccctgat agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga     7680

ctcttgttcc aaactggaac aacactcaac cctatctcgg tctattcttt tgatttataa     7740

gggattttgc cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac     7800

gcgaatttta acaaaatatt aacgtttaca atttcc                               7836


