                               SEQUENCE LISTING

<110> THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
 
<120> METHODS AND ASSAYS RELATING TO MACROPHAGE DIFFERENTIATION

<130> 043214-076601-PCT

<140>
<141>

<150> 61/737,462
<151> 2012-12-14

<160> 68    

<170> PatentIn version 3.5

<210> 1
<211> 6650
<212> DNA
<213> Homo sapiens

<400> 1
gctggttccc cttccgagcg tccgcgcccc gcatgcgcag tctgccccgg cggtctccgt       60

ttgtttgaac aggaaggcgg acatattagt ccctctcagc ccccctcgcc ccacccccca      120

ggcattcgcc gccgcgactc gccctttccc cggctgggac cgcagcccct cccagaagct      180

cccccatcag cagccgccgg gacccaacta tcgtcttcct cttcgcccgc tctccagcct      240

ttcctctgct aagtctccat cgggcatcga cctcgccctg ccccaccgga caccgtagca      300

gcagccccag cagcgacggg acaaaatggg agagtgaggc tgtcctgcgt ggaccagctc      360

gtggccgaga ctgatcggtg cgtcgggccg ggccgagtag agccggggac gcggggctag      420

accgtctaca gcgcctctga gcggagcggg cccggcccgt ggcccgagcg gcggccgcag      480

ctggcacagc tcctcacccg ccctttgctt tcgcctttcc tcttctccct cccttgttgc      540

ccggagggag tctccaccct gcttctcttt ctctacccgc tcctgcccat ctcgggacgg      600

ggacccctcc atggcgacgg cggccggggc ccgctagact gaagcacctc gccggagcga      660

cgaggctggt ggcgacggcg ctgtcggctg tcgtgagggg ctgccgggtg ggatgcgact      720

ttgggcgtcc gagcggctgt gggtcgctgt tgcccccggc ccggggtctg gagagcggag      780

gtcccctcag tgaggggaag acgggggaac cgggcgcacc tggtgaccct gaggttccgg      840

ctcctccgcc ccgcggctgc gaacccaccg cggaggaagt tggttgaaat tgctttccgc      900

tgctggtgct ggtaagaggg cattgtcaca gcagcagcaa catgtcgact ggggacagtt      960

ttgagactcg atttgaaaaa atggacaacc tgctgcggga tcccaaatcg gaagtgaatt     1020

cggattgttt gctggatgga ttggatgctt tggtatatga tttggatttt cctgccttaa     1080

gaaaaaacaa aaatattgac aactttttaa gcagatataa agacacaata aataaaatca     1140

gagatttacg aatgaaagct gaagattatg aagtagtgaa ggtgattggt agaggtgcat     1200

ttggagaagt tcaattggta aggcataaat ccaccaggaa ggtatatgct atgaagcttc     1260

tcagcaaatt tgaaatgata aagagatctg attctgcttt tttctgggaa gaaagggaca     1320

tcatggcttt tgccaacagt ccttgggttg ttcagctttt ttatgcattc caagatgatc     1380

gttatctcta catggtgatg gaatacatgc ctggtggaga tcttgtaaac ttaatgagca     1440

actatgatgt gcctgaaaaa tgggcacgat tctatactgc agaagtagtt cttgcattgg     1500

atgcaatcca ttccatgggt tttattcaca gagatgtgaa gcctgataac atgctgctgg     1560

ataaatctgg acatttgaag ttagcagatt ttggtacttg tatgaagatg aataaggaag     1620

gcatggtacg atgtgataca gcggttggaa cacctgatta tatttcccct gaagtattaa     1680

aatcccaagg tggtgatggt tattatggaa gagaatgtga ctggtggtcg gttggggtat     1740

ttttatacga aatgcttgta ggtgatacac ctttttatgc agattctttg gttggaactt     1800

acagtaaaat tatgaaccat aaaaattcac ttacctttcc tgatgataat gacatatcaa     1860

aagaagcaaa aaaccttatt tgtgccttcc ttactgacag ggaagtgagg ttagggcgaa     1920

atggtgtaga agaaatcaaa cgacatctct tcttcaaaaa tgaccagtgg gcttgggaaa     1980

cgctccgaga cactgtagca ccagttgtac ccgatttaag tagtgacatt gatactagta     2040

attttgatga cttggaagaa gataaaggag aggaagaaac attccctatt cctaaagctt     2100

tcgttggcaa tcaactacct tttgtaggat ttacatatta tagcaatcgt agatacttat     2160

cttcagcaaa tcctaatgat aacagaacta gctccaatgc agataaaagc ttgcaggaaa     2220

gtttgcaaaa aacaatctat aagctggaag aacagctgca taatgaaatg cagttaaaag     2280

atgaaatgga gcagaagtgc agaacctcaa acataaaact agacaagata atgaaagaat     2340

tggatgaaga gggaaatcaa agaagaaatc tagaatctac agtgtctcag attgagaagg     2400

agaaaatgtt gctacagcat agaattaatg agtaccaaag aaaagctgaa caggaaaatg     2460

agaagagaag aaatgtagaa aatgaagttt ctacattaaa ggatcagttg gaagacttaa     2520

agaaagtcag tcagaattca cagcttgcta atgagaagct gtcccagtta caaaagcagc     2580

tagaagaagc caatgactta cttaggacag aatcggacac agctgtaaga ttgaggaaga     2640

gtcacacaga gatgagcaag tcaattagtc agttagagtc cctgaacaga gagttgcaag     2700

agagaaatcg aattttagag aattctaagt cacaaacaga caaagattat taccagctgc     2760

aagctatatt agaagctgaa cgaagagaca gaggtcatga ttctgagatg attggagacc     2820

ttcaagctcg aattacatct ttacaagagg aggtgaagca tctcaaacat aatctcgaaa     2880

aagtggaagg agaaagaaaa gaggctcaag acatgcttaa tcactcagaa aaggaaaaga     2940

ataatttaga gatagattta aactacaaac ttaaatcatt acaacaacgg ttagaacaag     3000

aggtaaatga acacaaagta accaaagctc gtttaactga caaacatcaa tctattgaag     3060

aggcaaagtc tgtggcaatg tgtgagatgg aaaaaaagct gaaagaagaa agagaagctc     3120

gagagaaggc tgaaaatcgg gttgttcaga ttgagaaaca gtgttccatg ctagacgttg     3180

atctgaagca atctcagcag aaactagaac atttgactgg aaataaagaa aggatggagg     3240

atgaagttaa gaatctaacc ctgcaactgg agcaggaatc aaataagcgg ctgttgttac     3300

aaaatgaatt gaagactcaa gcatttgagg cagacaattt aaaaggttta gaaaagcaga     3360

tgaaacagga aataaatact ttattggaag caaagagatt attagaattt gagttagctc     3420

agcttacgaa acagtataga ggaaatgaag gacagatgcg ggagctacaa gatcagcttg     3480

aagctgagca atatttctcg acactttata aaacccaggt aaaggaactt aaagaagaaa     3540

ttgaagaaaa aaacagagaa aatttaaaga aaatacagga actacaaaat gaaaaagaaa     3600

ctcttgctac tcagttggat ctagcagaaa caaaagctga gtctgagcag ttggcgcgag     3660

gccttctgga agaacagtat tttgaattga cgcaagaaag caagaaagct gcttcaagaa     3720

atagacaaga gattacagat aaagatcaca ctgttagtcg gcttgaagaa gcaaacagca     3780

tgctaaccaa agatattgaa atattaagaa gagagaatga agagctaaca gagaaaatga     3840

agaaggcaga ggaagaatat aaactggaga aggaggagga gatcagtaat cttaaggctg     3900

cctttgaaaa gaatatcaac actgaacgaa cccttaaaac acaggctgtt aacaaattgg     3960

cagaaataat gaatcgaaaa gattttaaaa ttgatagaaa gaaagctaat acacaagatt     4020

tgagaaagaa agaaaaggaa aatcgaaagc tgcaactgga actcaaccaa gaaagagaga     4080

aattcaacca gatggtagtg aaacatcaga aggaactgaa tgacatgcaa gcgcaattgg     4140

tagaagaatg tgcacatagg aatgagcttc agatgcagtt ggccagcaaa gagagtgata     4200

ttgagcaatt gcgtgctaaa cttttggacc tctcggattc tacaagtgtt gctagttttc     4260

ctagtgctga tgaaactgat ggtaacctcc cagagtcaag aattgaaggt tggctttcag     4320

taccaaatag aggaaatatc aaacgatatg gctggaagaa acagtatgtt gtggtaagca     4380

gcaaaaaaat tttgttctat aatgacgaac aagataagga gcaatccaat ccatctatgg     4440

tattggacat agataaactg tttcacgtta gacctgtaac ccaaggagat gtgtatagag     4500

ctgaaactga agaaattcct aaaatattcc agatactata tgcaaatgaa ggtgaatgta     4560

gaaaagatgt agagatggaa ccagtacaac aagctgaaaa aactaatttc caaaatcaca     4620

aaggccatga gtttattcct acactctacc actttcctgc caattgtgat gcctgtgcca     4680

aacctctctg gcatgttttt aagccacccc ctgccctaga gtgtcgaaga tgccatgtta     4740

agtgccacag agatcactta gataagaaag aggacttaat ttgtccatgt aaagtaagtt     4800

atgatgtaac atcagcaaga gatatgctgc tgttagcatg ttctcaggat gaacaaaaaa     4860

aatgggtaac tcatttagta aagaaaatcc ctaagaatcc accatctggt tttgttcgtg     4920

cttcccctcg aacgctttct acaagatcca ctgcaaatca gtctttccgg aaagtggtca     4980

aaaatacatc tggaaaaact agttaaccat gtgactgagt gccctgtgga atcgtgtggg     5040

atgctacctg ataaaccagg cttctttaac catgcagagc agacaggctg tttctttgac     5100

acaaatatca caggcttcag ggttaagatt gctgtttttc tgtccttgct ttggcacaac     5160

acactgaggg ttttttttat tgcgggtttg cctacaggta gattagatta attattacta     5220

tgtaatgcaa gtacagttgg gggaaagctt aggtagatat atttttttta aaaggtgctg     5280

cctttttgga tttataagaa aatgcctgtc agtcgtgata gaacagagtt ttcctcatat     5340

gagtaagagg aagggacttt cactttcaag tggaacagcc atcactatca agatcagctc     5400

atggaaggag taaagaaaat atctcaaaat gagacaaact gaagttttgt ttttttttta     5460

atgacttaag tttttgtgct cttgcaagac tatacaaaac tattttaaga aagcagtgat     5520

atcacttgaa cttcagtgcc ctcactgtag aatttaaaag ccttactgtt gattgcccat     5580

gttggacttg atggagaaat taaatatctt tcattatgct ttacaaaata ctgtatatgt     5640

ttcagcaagt ttggggaatg ggagaggaca aaaaaaagtt acatttaatc tatgcatttt     5700

tgccaagcca tattgagtta ttttactact agagacatta ggaaactaac tgtacaaaag     5760

aaccaagttt aaaagcattt tgtggggtac atcatttcta taattgtata atgtatttct     5820

ttgtggtttt aaatgataaa gacattaagt taacaaacat ataagaaatg tatgcactgt     5880

ttgaaatgta aattattctt agaacacttt caatgggggt tgcattgtcc ttttagtgcc     5940

ttaatttgag ataattattt tactgccatg agtaagtata gaaatttcaa aaaatgtatt     6000

ttcaaaaaat tatgtgtgtc agtgagtttt tcattgataa ttggtttaat ttaaaatatt     6060

tagaggtttg ttggactttc ataaattgag tacaatcttt gcatcaaact acctgctaca     6120

ataatgactt tataaaactg caaaaaatgt agaaggttgc accaacataa aaaggaaata     6180

tggcaataca tccatgatgt tttccagtta acataggaat taccagataa atactgttaa     6240

actcttgtcc agtaacaaga gttgattcat atggacagta tgatttattg tttatttttt     6300

taaccaaata cctcctcagt aatttataat ggctttgcag taatgtgtat cagataagaa     6360

gcactggaaa accgatcgtc tctaggatga tatgcatgtt tcaagtggta ttgaaagccg     6420

cactgatgga tatgtaataa taaacatatc tgttattaat atactaatga ctctgtgctc     6480

atttaatgag aaataaaagt aatttatgga tgggtatctt taatttttac tgcaatgtgt     6540

tttctcatgg ctgaaatgaa tggaaaacat acttcaaatt agtctctgat tgtatataaa     6600

tgtttgtgaa attccatggt tagattaaag tgtattttta aaagataaaa                6650


<210> 2
<211> 1354
<212> PRT
<213> Homo sapiens

<400> 2
Met Ser Thr Gly Asp Ser Phe Glu Thr Arg Phe Glu Lys Met Asp Asn 
1               5                   10                  15      


Leu Leu Arg Asp Pro Lys Ser Glu Val Asn Ser Asp Cys Leu Leu Asp 
            20                  25                  30          


Gly Leu Asp Ala Leu Val Tyr Asp Leu Asp Phe Pro Ala Leu Arg Lys 
        35                  40                  45              


Asn Lys Asn Ile Asp Asn Phe Leu Ser Arg Tyr Lys Asp Thr Ile Asn 
    50                  55                  60                  


Lys Ile Arg Asp Leu Arg Met Lys Ala Glu Asp Tyr Glu Val Val Lys 
65                  70                  75                  80  


Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys 
                85                  90                  95      


Ser Thr Arg Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met 
            100                 105                 110         


Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met 
        115                 120                 125             


Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln 
    130                 135                 140                 


Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp 
145                 150                 155                 160 


Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Arg 
                165                 170                 175     


Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met 
            180                 185                 190         


Gly Phe Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys 
        195                 200                 205             


Ser Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asn 
    210                 215                 220                 


Lys Glu Gly Met Val Arg Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr 
225                 230                 235                 240 


Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Tyr Tyr Gly 
                245                 250                 255     


Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu 
            260                 265                 270         


Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser 
        275                 280                 285             


Lys Ile Met Asn His Lys Asn Ser Leu Thr Phe Pro Asp Asp Asn Asp 
    290                 295                 300                 


Ile Ser Lys Glu Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg 
305                 310                 315                 320 


Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Lys Arg His Leu 
                325                 330                 335     


Phe Phe Lys Asn Asp Gln Trp Ala Trp Glu Thr Leu Arg Asp Thr Val 
            340                 345                 350         


Ala Pro Val Val Pro Asp Leu Ser Ser Asp Ile Asp Thr Ser Asn Phe 
        355                 360                 365             


Asp Asp Leu Glu Glu Asp Lys Gly Glu Glu Glu Thr Phe Pro Ile Pro 
    370                 375                 380                 


Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Val Gly Phe Thr Tyr Tyr 
385                 390                 395                 400 


Ser Asn Arg Arg Tyr Leu Ser Ser Ala Asn Pro Asn Asp Asn Arg Thr 
                405                 410                 415     


Ser Ser Asn Ala Asp Lys Ser Leu Gln Glu Ser Leu Gln Lys Thr Ile 
            420                 425                 430         


Tyr Lys Leu Glu Glu Gln Leu His Asn Glu Met Gln Leu Lys Asp Glu 
        435                 440                 445             


Met Glu Gln Lys Cys Arg Thr Ser Asn Ile Lys Leu Asp Lys Ile Met 
    450                 455                 460                 


Lys Glu Leu Asp Glu Glu Gly Asn Gln Arg Arg Asn Leu Glu Ser Thr 
465                 470                 475                 480 


Val Ser Gln Ile Glu Lys Glu Lys Met Leu Leu Gln His Arg Ile Asn 
                485                 490                 495     


Glu Tyr Gln Arg Lys Ala Glu Gln Glu Asn Glu Lys Arg Arg Asn Val 
            500                 505                 510         


Glu Asn Glu Val Ser Thr Leu Lys Asp Gln Leu Glu Asp Leu Lys Lys 
        515                 520                 525             


Val Ser Gln Asn Ser Gln Leu Ala Asn Glu Lys Leu Ser Gln Leu Gln 
    530                 535                 540                 


Lys Gln Leu Glu Glu Ala Asn Asp Leu Leu Arg Thr Glu Ser Asp Thr 
545                 550                 555                 560 


Ala Val Arg Leu Arg Lys Ser His Thr Glu Met Ser Lys Ser Ile Ser 
                565                 570                 575     


Gln Leu Glu Ser Leu Asn Arg Glu Leu Gln Glu Arg Asn Arg Ile Leu 
            580                 585                 590         


Glu Asn Ser Lys Ser Gln Thr Asp Lys Asp Tyr Tyr Gln Leu Gln Ala 
        595                 600                 605             


Ile Leu Glu Ala Glu Arg Arg Asp Arg Gly His Asp Ser Glu Met Ile 
    610                 615                 620                 


Gly Asp Leu Gln Ala Arg Ile Thr Ser Leu Gln Glu Glu Val Lys His 
625                 630                 635                 640 


Leu Lys His Asn Leu Glu Lys Val Glu Gly Glu Arg Lys Glu Ala Gln 
                645                 650                 655     


Asp Met Leu Asn His Ser Glu Lys Glu Lys Asn Asn Leu Glu Ile Asp 
            660                 665                 670         


Leu Asn Tyr Lys Leu Lys Ser Leu Gln Gln Arg Leu Glu Gln Glu Val 
        675                 680                 685             


Asn Glu His Lys Val Thr Lys Ala Arg Leu Thr Asp Lys His Gln Ser 
    690                 695                 700                 


Ile Glu Glu Ala Lys Ser Val Ala Met Cys Glu Met Glu Lys Lys Leu 
705                 710                 715                 720 


Lys Glu Glu Arg Glu Ala Arg Glu Lys Ala Glu Asn Arg Val Val Gln 
                725                 730                 735     


Ile Glu Lys Gln Cys Ser Met Leu Asp Val Asp Leu Lys Gln Ser Gln 
            740                 745                 750         


Gln Lys Leu Glu His Leu Thr Gly Asn Lys Glu Arg Met Glu Asp Glu 
        755                 760                 765             


Val Lys Asn Leu Thr Leu Gln Leu Glu Gln Glu Ser Asn Lys Arg Leu 
    770                 775                 780                 


Leu Leu Gln Asn Glu Leu Lys Thr Gln Ala Phe Glu Ala Asp Asn Leu 
785                 790                 795                 800 


Lys Gly Leu Glu Lys Gln Met Lys Gln Glu Ile Asn Thr Leu Leu Glu 
                805                 810                 815     


Ala Lys Arg Leu Leu Glu Phe Glu Leu Ala Gln Leu Thr Lys Gln Tyr 
            820                 825                 830         


Arg Gly Asn Glu Gly Gln Met Arg Glu Leu Gln Asp Gln Leu Glu Ala 
        835                 840                 845             


Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val Lys Glu Leu Lys 
    850                 855                 860                 


Glu Glu Ile Glu Glu Lys Asn Arg Glu Asn Leu Lys Lys Ile Gln Glu 
865                 870                 875                 880 


Leu Gln Asn Glu Lys Glu Thr Leu Ala Thr Gln Leu Asp Leu Ala Glu 
                885                 890                 895     


Thr Lys Ala Glu Ser Glu Gln Leu Ala Arg Gly Leu Leu Glu Glu Gln 
            900                 905                 910         


Tyr Phe Glu Leu Thr Gln Glu Ser Lys Lys Ala Ala Ser Arg Asn Arg 
        915                 920                 925             


Gln Glu Ile Thr Asp Lys Asp His Thr Val Ser Arg Leu Glu Glu Ala 
    930                 935                 940                 


Asn Ser Met Leu Thr Lys Asp Ile Glu Ile Leu Arg Arg Glu Asn Glu 
945                 950                 955                 960 


Glu Leu Thr Glu Lys Met Lys Lys Ala Glu Glu Glu Tyr Lys Leu Glu 
                965                 970                 975     


Lys Glu Glu Glu Ile Ser Asn Leu Lys Ala Ala Phe Glu Lys Asn Ile 
            980                 985                 990         


Asn Thr Glu Arg Thr Leu Lys Thr  Gln Ala Val Asn Lys  Leu Ala Glu 
        995                 1000                 1005             


Ile Met  Asn Arg Lys Asp Phe  Lys Ile Asp Arg Lys  Lys Ala Asn 
    1010                 1015                 1020             


Thr Gln  Asp Leu Arg Lys Lys  Glu Lys Glu Asn Arg  Lys Leu Gln 
    1025                 1030                 1035             


Leu Glu  Leu Asn Gln Glu Arg  Glu Lys Phe Asn Gln  Met Val Val 
    1040                 1045                 1050             


Lys His  Gln Lys Glu Leu Asn  Asp Met Gln Ala Gln  Leu Val Glu 
    1055                 1060                 1065             


Glu Cys  Ala His Arg Asn Glu  Leu Gln Met Gln Leu  Ala Ser Lys 
    1070                 1075                 1080             


Glu Ser  Asp Ile Glu Gln Leu  Arg Ala Lys Leu Leu  Asp Leu Ser 
    1085                 1090                 1095             


Asp Ser  Thr Ser Val Ala Ser  Phe Pro Ser Ala Asp  Glu Thr Asp 
    1100                 1105                 1110             


Gly Asn  Leu Pro Glu Ser Arg  Ile Glu Gly Trp Leu  Ser Val Pro 
    1115                 1120                 1125             


Asn Arg  Gly Asn Ile Lys Arg  Tyr Gly Trp Lys Lys  Gln Tyr Val 
    1130                 1135                 1140             


Val Val  Ser Ser Lys Lys Ile  Leu Phe Tyr Asn Asp  Glu Gln Asp 
    1145                 1150                 1155             


Lys Glu  Gln Ser Asn Pro Ser  Met Val Leu Asp Ile  Asp Lys Leu 
    1160                 1165                 1170             


Phe His  Val Arg Pro Val Thr  Gln Gly Asp Val Tyr  Arg Ala Glu 
    1175                 1180                 1185             


Thr Glu  Glu Ile Pro Lys Ile  Phe Gln Ile Leu Tyr  Ala Asn Glu 
    1190                 1195                 1200             


Gly Glu  Cys Arg Lys Asp Val  Glu Met Glu Pro Val  Gln Gln Ala 
    1205                 1210                 1215             


Glu Lys  Thr Asn Phe Gln Asn  His Lys Gly His Glu  Phe Ile Pro 
    1220                 1225                 1230             


Thr Leu  Tyr His Phe Pro Ala  Asn Cys Asp Ala Cys  Ala Lys Pro 
    1235                 1240                 1245             


Leu Trp  His Val Phe Lys Pro  Pro Pro Ala Leu Glu  Cys Arg Arg 
    1250                 1255                 1260             


Cys His  Val Lys Cys His Arg  Asp His Leu Asp Lys  Lys Glu Asp 
    1265                 1270                 1275             


Leu Ile  Cys Pro Cys Lys Val  Ser Tyr Asp Val Thr  Ser Ala Arg 
    1280                 1285                 1290             


Asp Met  Leu Leu Leu Ala Cys  Ser Gln Asp Glu Gln  Lys Lys Trp 
    1295                 1300                 1305             


Val Thr  His Leu Val Lys Lys  Ile Pro Lys Asn Pro  Pro Ser Gly 
    1310                 1315                 1320             


Phe Val  Arg Ala Ser Pro Arg  Thr Leu Ser Thr Arg  Ser Thr Ala 
    1325                 1330                 1335             


Asn Gln  Ser Phe Arg Lys Val  Val Lys Asn Thr Ser  Gly Lys Thr 
    1340                 1345                 1350             


Ser 
    


<210> 3
<211> 6401
<212> DNA
<213> Homo sapiens

<400> 3
caaggcggcc ggcggcgacc atggcagcgg gccggcggcg gccgtagtgg cccaggcctg       60

ggcttcagcc tcccggggcc ccagagggcg gggcggtccg ggccgcggcg gtggcggcgc      120

cacttccctg ctcccgcccg aggactcctg cgggcactcg ctgaggacca gcggaccggc      180

ggcgcgaatc tgactgaggg gcggggacgc cgtctgttcc ccgccgctcc cggcagggcc      240

gggccgggct gggccgggct gggccgggcg ggcccctggg agcagccccc aggcggggga      300

ccgccttgga gacccgaagc cggagctaga ggcaggcggt gggcccgggt ggagtcccgg      360

ccggagctgg tggttcgggg gcggtgctag gccccgaggc tgcgggacct gagcgcgagg      420

agcctgagtg cgggtccagc ggtggcggca tgagccggcc cccgccgacg gggaaaatgc      480

ccggcgcccc cgagaccgcg ccgggggacg gggcaggcgc gagccgccag aggaagctgg      540

aggcgctgat ccgagaccct cgctccccca tcaacgtgga gagcttgctg gatggcttaa      600

attccttggt ccttgattta gattttcctg ctttgaggaa aaacaagaac atagataatt      660

tcttaaatag atatgagaaa attgtgaaaa aaatcagagg tctacagatg aaggcagaag      720

actatgatgt tgtaaaagtt attggaagag gtgcttttgg tgaagtgcag ttggttcgtc      780

acaaggcatc gcagaaggtt tatgctatga agcttcttag taagtttgaa atgataaaaa      840

gatcagattc tgcctttttt tgggaagaaa gagatattat ggcctttgcc aatagcccct      900

gggtggttca gcttttttat gcctttcaag atgataggta tctgtacatg gtaatggagt      960

acatgcctgg tggagacctt gtaaacctta tgagtaatta tgatgtgcct gaaaaatggg     1020

ccaaatttta cactgctgaa gttgttcttg ctctggatgc aatacactcc atgggtttaa     1080

tacacagaga tgtgaagcct gacaacatgc tcttggataa acatggacat ctaaaattag     1140

cagattttgg cacgtgtatg aagatggatg aaacaggcat ggtacattgt gatacagcag     1200

ttggaacacc ggattatata tcacctgagg ttctgaaatc acaagggggt gatggtttct     1260

atgggcgaga atgtgattgg tggtctgtag gtgttttcct ttatgagatg ctagtggggg     1320

atactccatt ttatgcggat tcacttgtag gaacatatag caaaattatg gatcataaga     1380

attcactgtg tttccctgaa gatgcagaaa tttccaaaca tgcaaagaat ctcatctgtg     1440

ctttcttaac agatagggag gtacgacttg ggagaaatgg ggtggaagaa atcagacagc     1500

atcctttctt taagaatgat cagtggcatt gggataacat aagagaaacg gcagctcctg     1560

tagtacctga actcagcagt gacatagaca gcagcaattt cgatgacatt gaagatgaca     1620

aaggagatgt agaaaccttc ccaattccta aagcttttgt tggaaatcag ctgcctttca     1680

tcggatttac ctactataga gaaaatttat tattaagtga ctctccatct tgtagagaaa     1740

ctgattccat acaatcaagg aaaaatgaag aaagtcaaga gattcagaaa aaactgtata     1800

cattagaaga acatcttagc aatgagatgc aagccaaaga ggaactggaa cagaagtgca     1860

aatctgttaa tactcgccta gaaaaaacag caaaggagct agaagaggag attaccttac     1920

ggaaaagtgt ggaatcagca ttaagacagt tagaaagaga aaaggcgctt cttcagcaca     1980

aaaatgcaga atatcagagg aaagctgatc atgaagcaga caaaaaacga aatttggaaa     2040

atgatgttaa cagcttaaaa gatcaacttg aagatttgaa aaaaagaaat caaaactctc     2100

aaatatccac tgagaaagtg aatcaactcc agagacaact ggatgaaacc aatgctttac     2160

tgcgaacaga gtctgatact gcagcccggt taaggaaaac ccaggcagaa agttcaaaac     2220

agattcagca gctggaatct aacaatagag atctacaaga taaaaactgc ctgctggaga     2280

ctgccaagtt aaaacttgaa aaggaattta tcaatcttca gtcagctcta gaatctgaaa     2340

ggagggatcg aacccatgga tcagagataa ttaatgattt acaaggtaga atatgtggcc     2400

tagaagaaga tttaaagaac ggcaaaatct tactagcgaa agtagaactg gagaagagac     2460

aacttcagga gagatttact gatttggaaa aggaaaaaag caacatggaa atagatatga     2520

cataccaact aaaagttata cagcagagcc tagaacaaga agaagctgaa cataaggcca     2580

caaaggcacg actagcagat aaaaataaga tctatgagtc catcgaagaa gccaaatcag     2640

aagccatgaa agaaatggag aagaagctct tggaggaaag aactttaaaa cagaaagtgg     2700

agaacctatt gctagaagct gagaaaagat gttctctatt agactgtgac ctcaaacagt     2760

cacagcagaa aataaatgag ctccttaaac agaaagatgt gctaaatgag gatgttagaa     2820

acctgacatt aaaaatagag caagaaactc agaagcgctg ccttacacaa aatgacctga     2880

agatgcaaac acaacaggtt aacacactaa aaatgtcaga aaagcagtta aagcaagaaa     2940

ataaccatct catggaaatg aaaatgaact tggaaaaaca aaatgctgaa cttcgaaaag     3000

aacgtcagga tgcagatggg caaatgaaag agctccagga tcagctcgaa gcagaacagt     3060

atttctcaac cctttataaa acacaagtta gggagcttaa agaagaatgt gaagaaaaga     3120

ccaaacttgg taaagaattg cagcagaaga aacaggaatt acaggatgaa cgggactctt     3180

tggctgccca actggagatc accttgacca aagcagattc tgagcaactg gctcgttcaa     3240

ttgctgaaga acaatattct gatttggaaa aagagaagat catgaaagag ctggagatca     3300

aagagatgat ggctagacac aaacaggaac ttacggaaaa agatgctaca attgcttctc     3360

ttgaggaaac taataggaca ctaactagtg atgttgccaa tcttgcaaat gagaaagaag     3420

aattaaataa caaattgaaa gatgttcaag agcaactgtc aagattgaaa gatgaagaaa     3480

taagcgcagc agctattaaa gcacagtttg agaagcagct attaacagaa agaacactca     3540

aaactcaagc tgtgaataag ttggctgaga tcatgaatcg aaaagaacct gtcaagcgtg     3600

gtaatgacac agatgtgcgg agaaaagaga aggagaatag aaagctacat atggagctta     3660

aatctgaacg tgagaaattg acccagcaga tgatcaagta tcagaaagaa ctgaatgaaa     3720

tgcaggcaca aatagctgaa gagagccaga ttcgaattga actgcagatg acattggaca     3780

gtaaagacag tgacattgag cagctgcggt cacaactcca agccttgcat attggtctgg     3840

atagttccag tataggcagt ggaccagggg atgctgaggc agatgatggg tttccagaat     3900

caagattaga aggatggctt tcattgcctg tacgaaacaa cactaagaaa tttggatggg     3960

ttaaaaagta tgtgattgta agcagtaaga agattctttt ctatgacagt gaacaagata     4020

aagaacaatc caatccttac atggttttag atatagacaa gttatttcat gtccgaccag     4080

ttacacagac agatgtgtat agagcagatg ctaaagaaat tccaaggata ttccagattc     4140

tgtatgccaa tgaaggagaa agtaagaagg aacaagaatt tccagtggag ccagttggag     4200

aaaaatctaa ttatatttgc cacaagggac atgagtttat tcctactctt tatcatttcc     4260

caaccaactg tgaggcttgt atgaagcccc tgtggcacat gtttaagcct cctcctgctt     4320

tggagtgccg ccgttgccat attaagtgtc ataaagatca tatggacaaa aaggaggaga     4380

ttatagcacc ttgcaaagta tattatgata tttcaacggc aaagaatctg ttattactag     4440

caaattctac agaagagcag cagaagtggg ttagtcggtt ggtgaaaaag atacctaaaa     4500

agcccccagc tccagaccct tttgcccgat catctcctag aacttcaatg aagatacagc     4560

aaaaccagtc tattagacgg ccaagtcgac agcttgcccc aaacaaacct agctaactgc     4620

cttctatgaa agcagtcatt attcaaggtg atcgtattct tccagtgaaa acaagactga     4680

aatatgatgg cccaaaattt attaaaaagc tatattttcc tgagagactg atacatacac     4740

tcatacatat atgtgttccc cttttccctg taatataaat tacaaatctg ggctcctttg     4800

aagcaacagg ttgaaccaac aatgattggt tgatagacta aggatatatg caactcttcc     4860

agacttttcc ataaagctct ctcggcagtc gctcacacta caatgcacac aaggattgag     4920

aagagttaaa ggctaaagaa aacatctttt ctagcttcaa cagagaggtt tcaccagcac     4980

atttaccaga agaatctggg aatggattcc actacagtga tattgactgc atctttaaga     5040

agtgaccatt atactgtgta tatatatata aacacacaca catatatata tatatatata     5100

gtactctaat actgcaagaa ggttttttaa acttcccact ttatttttta tacacattaa     5160

tcagatatca ttacttgctg cagttgcaac tatgcacttg tataaagcca taatgttgga     5220

gtttatatca ctcattcctg tgtacctgat ggaagttgca tgttcatgtt taagcagtta     5280

ctgtaacaag aagtttaaag ttaattatat cagtttccta atgcttcatg ataggcaact     5340

ttacccattt tgaatgcctt aatttaattt ttttcaaagt ctcagccctg tctgtattaa     5400

aaaacaaaaa aagcgtttac cagctcttag gatgtaaact agctttgtgg aagataaatc     5460

gtgcactatt tttacacata aatagttata tcaatgtcag cctattttga ttaacaaatg     5520

tttttaaagt attattggtt atagaaacaa taatggatgg tgttggaact aatatatcct     5580

tgatgtctgt ctattattca ttcaactctt tttacagacc tcagtattag tctgtgacta     5640

caaaatattt tatttgcttt aaatttgctg gctaccctag atgtgttttt attcctggta     5700

aagacatttg tgattacatt ttcacactta agattcaaaa tttttcccaa atataaagaa     5760

aactaagaca gactgtagat gcattttaaa tatttaaata tgatcctcag acatgcagct     5820

gtgtgtggca gtattttagt accgggttaa gaaaactggc aactgggaag aagtggcctc     5880

aaaggcactt aatttgattt ttatttttta aatgctgtca aagttacagt ttacgcagga     5940

cattcttgcc gtattctcat gatcccagat aagtgtgtgt tttatactgc aacaatatgc     6000

agcaatggta agcgtaaagt tttttttttg tttttgtttt tttttatatt atgaagtctt     6060

ttaacagtct ctctttatat aaatacacag agtttggtat gatatttaaa tacatcatct     6120

ggccaggcat ggtggcttac gcctgtaatc ctagcacttt gggaggccaa gacgggcgga     6180

tcacctgagg tgaggagttc aagaccagcc tgcccaacat agtgaaactc cgtctctacc     6240

aatatacaaa aattagccgg gcatgatggt ggtggcctgt aatcccagct acttgggagg     6300

ctgagacagg agaatcgctt gaacccagga gacggtggtt gcagtgagcg aagatcgagc     6360

cactgcactc cagcctgggc agctgaacaa gactccgtct c                         6401


<210> 4
<211> 1388
<212> PRT
<213> Homo sapiens

<400> 4
Met Ser Arg Pro Pro Pro Thr Gly Lys Met Pro Gly Ala Pro Glu Thr 
1               5                   10                  15      


Ala Pro Gly Asp Gly Ala Gly Ala Ser Arg Gln Arg Lys Leu Glu Ala 
            20                  25                  30          


Leu Ile Arg Asp Pro Arg Ser Pro Ile Asn Val Glu Ser Leu Leu Asp 
        35                  40                  45              


Gly Leu Asn Ser Leu Val Leu Asp Leu Asp Phe Pro Ala Leu Arg Lys 
    50                  55                  60                  


Asn Lys Asn Ile Asp Asn Phe Leu Asn Arg Tyr Glu Lys Ile Val Lys 
65                  70                  75                  80  


Lys Ile Arg Gly Leu Gln Met Lys Ala Glu Asp Tyr Asp Val Val Lys 
                85                  90                  95      


Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys 
            100                 105                 110         


Ala Ser Gln Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met 
        115                 120                 125             


Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met 
    130                 135                 140                 


Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln 
145                 150                 155                 160 


Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp 
                165                 170                 175     


Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Lys 
            180                 185                 190         


Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met 
        195                 200                 205             


Gly Leu Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys 
    210                 215                 220                 


His Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asp 
225                 230                 235                 240 


Glu Thr Gly Met Val His Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr 
                245                 250                 255     


Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Phe Tyr Gly 
            260                 265                 270         


Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu 
        275                 280                 285             


Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser 
    290                 295                 300                 


Lys Ile Met Asp His Lys Asn Ser Leu Cys Phe Pro Glu Asp Ala Glu 
305                 310                 315                 320 


Ile Ser Lys His Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg 
                325                 330                 335     


Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Arg Gln His Pro 
            340                 345                 350         


Phe Phe Lys Asn Asp Gln Trp His Trp Asp Asn Ile Arg Glu Thr Ala 
        355                 360                 365             


Ala Pro Val Val Pro Glu Leu Ser Ser Asp Ile Asp Ser Ser Asn Phe 
    370                 375                 380                 


Asp Asp Ile Glu Asp Asp Lys Gly Asp Val Glu Thr Phe Pro Ile Pro 
385                 390                 395                 400 


Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Ile Gly Phe Thr Tyr Tyr 
                405                 410                 415     


Arg Glu Asn Leu Leu Leu Ser Asp Ser Pro Ser Cys Arg Glu Thr Asp 
            420                 425                 430         


Ser Ile Gln Ser Arg Lys Asn Glu Glu Ser Gln Glu Ile Gln Lys Lys 
        435                 440                 445             


Leu Tyr Thr Leu Glu Glu His Leu Ser Asn Glu Met Gln Ala Lys Glu 
    450                 455                 460                 


Glu Leu Glu Gln Lys Cys Lys Ser Val Asn Thr Arg Leu Glu Lys Thr 
465                 470                 475                 480 


Ala Lys Glu Leu Glu Glu Glu Ile Thr Leu Arg Lys Ser Val Glu Ser 
                485                 490                 495     


Ala Leu Arg Gln Leu Glu Arg Glu Lys Ala Leu Leu Gln His Lys Asn 
            500                 505                 510         


Ala Glu Tyr Gln Arg Lys Ala Asp His Glu Ala Asp Lys Lys Arg Asn 
        515                 520                 525             


Leu Glu Asn Asp Val Asn Ser Leu Lys Asp Gln Leu Glu Asp Leu Lys 
    530                 535                 540                 


Lys Arg Asn Gln Asn Ser Gln Ile Ser Thr Glu Lys Val Asn Gln Leu 
545                 550                 555                 560 


Gln Arg Gln Leu Asp Glu Thr Asn Ala Leu Leu Arg Thr Glu Ser Asp 
                565                 570                 575     


Thr Ala Ala Arg Leu Arg Lys Thr Gln Ala Glu Ser Ser Lys Gln Ile 
            580                 585                 590         


Gln Gln Leu Glu Ser Asn Asn Arg Asp Leu Gln Asp Lys Asn Cys Leu 
        595                 600                 605             


Leu Glu Thr Ala Lys Leu Lys Leu Glu Lys Glu Phe Ile Asn Leu Gln 
    610                 615                 620                 


Ser Ala Leu Glu Ser Glu Arg Arg Asp Arg Thr His Gly Ser Glu Ile 
625                 630                 635                 640 


Ile Asn Asp Leu Gln Gly Arg Ile Cys Gly Leu Glu Glu Asp Leu Lys 
                645                 650                 655     


Asn Gly Lys Ile Leu Leu Ala Lys Val Glu Leu Glu Lys Arg Gln Leu 
            660                 665                 670         


Gln Glu Arg Phe Thr Asp Leu Glu Lys Glu Lys Ser Asn Met Glu Ile 
        675                 680                 685             


Asp Met Thr Tyr Gln Leu Lys Val Ile Gln Gln Ser Leu Glu Gln Glu 
    690                 695                 700                 


Glu Ala Glu His Lys Ala Thr Lys Ala Arg Leu Ala Asp Lys Asn Lys 
705                 710                 715                 720 


Ile Tyr Glu Ser Ile Glu Glu Ala Lys Ser Glu Ala Met Lys Glu Met 
                725                 730                 735     


Glu Lys Lys Leu Leu Glu Glu Arg Thr Leu Lys Gln Lys Val Glu Asn 
            740                 745                 750         


Leu Leu Leu Glu Ala Glu Lys Arg Cys Ser Leu Leu Asp Cys Asp Leu 
        755                 760                 765             


Lys Gln Ser Gln Gln Lys Ile Asn Glu Leu Leu Lys Gln Lys Asp Val 
    770                 775                 780                 


Leu Asn Glu Asp Val Arg Asn Leu Thr Leu Lys Ile Glu Gln Glu Thr 
785                 790                 795                 800 


Gln Lys Arg Cys Leu Thr Gln Asn Asp Leu Lys Met Gln Thr Gln Gln 
                805                 810                 815     


Val Asn Thr Leu Lys Met Ser Glu Lys Gln Leu Lys Gln Glu Asn Asn 
            820                 825                 830         


His Leu Met Glu Met Lys Met Asn Leu Glu Lys Gln Asn Ala Glu Leu 
        835                 840                 845             


Arg Lys Glu Arg Gln Asp Ala Asp Gly Gln Met Lys Glu Leu Gln Asp 
    850                 855                 860                 


Gln Leu Glu Ala Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val 
865                 870                 875                 880 


Arg Glu Leu Lys Glu Glu Cys Glu Glu Lys Thr Lys Leu Gly Lys Glu 
                885                 890                 895     


Leu Gln Gln Lys Lys Gln Glu Leu Gln Asp Glu Arg Asp Ser Leu Ala 
            900                 905                 910         


Ala Gln Leu Glu Ile Thr Leu Thr Lys Ala Asp Ser Glu Gln Leu Ala 
        915                 920                 925             


Arg Ser Ile Ala Glu Glu Gln Tyr Ser Asp Leu Glu Lys Glu Lys Ile 
    930                 935                 940                 


Met Lys Glu Leu Glu Ile Lys Glu Met Met Ala Arg His Lys Gln Glu 
945                 950                 955                 960 


Leu Thr Glu Lys Asp Ala Thr Ile Ala Ser Leu Glu Glu Thr Asn Arg 
                965                 970                 975     


Thr Leu Thr Ser Asp Val Ala Asn Leu Ala Asn Glu Lys Glu Glu Leu 
            980                 985                 990         


Asn Asn Lys Leu Lys Asp Val Gln  Glu Gln Leu Ser Arg  Leu Lys Asp 
        995                 1000                 1005             


Glu Glu  Ile Ser Ala Ala Ala  Ile Lys Ala Gln Phe  Glu Lys Gln 
    1010                 1015                 1020             


Leu Leu  Thr Glu Arg Thr Leu  Lys Thr Gln Ala Val  Asn Lys Leu 
    1025                 1030                 1035             


Ala Glu  Ile Met Asn Arg Lys  Glu Pro Val Lys Arg  Gly Asn Asp 
    1040                 1045                 1050             


Thr Asp  Val Arg Arg Lys Glu  Lys Glu Asn Arg Lys  Leu His Met 
    1055                 1060                 1065             


Glu Leu  Lys Ser Glu Arg Glu  Lys Leu Thr Gln Gln  Met Ile Lys 
    1070                 1075                 1080             


Tyr Gln  Lys Glu Leu Asn Glu  Met Gln Ala Gln Ile  Ala Glu Glu 
    1085                 1090                 1095             


Ser Gln  Ile Arg Ile Glu Leu  Gln Met Thr Leu Asp  Ser Lys Asp 
    1100                 1105                 1110             


Ser Asp  Ile Glu Gln Leu Arg  Ser Gln Leu Gln Ala  Leu His Ile 
    1115                 1120                 1125             


Gly Leu  Asp Ser Ser Ser Ile  Gly Ser Gly Pro Gly  Asp Ala Glu 
    1130                 1135                 1140             


Ala Asp  Asp Gly Phe Pro Glu  Ser Arg Leu Glu Gly  Trp Leu Ser 
    1145                 1150                 1155             


Leu Pro  Val Arg Asn Asn Thr  Lys Lys Phe Gly Trp  Val Lys Lys 
    1160                 1165                 1170             


Tyr Val  Ile Val Ser Ser Lys  Lys Ile Leu Phe Tyr  Asp Ser Glu 
    1175                 1180                 1185             


Gln Asp  Lys Glu Gln Ser Asn  Pro Tyr Met Val Leu  Asp Ile Asp 
    1190                 1195                 1200             


Lys Leu  Phe His Val Arg Pro  Val Thr Gln Thr Asp  Val Tyr Arg 
    1205                 1210                 1215             


Ala Asp  Ala Lys Glu Ile Pro  Arg Ile Phe Gln Ile  Leu Tyr Ala 
    1220                 1225                 1230             


Asn Glu  Gly Glu Ser Lys Lys  Glu Gln Glu Phe Pro  Val Glu Pro 
    1235                 1240                 1245             


Val Gly  Glu Lys Ser Asn Tyr  Ile Cys His Lys Gly  His Glu Phe 
    1250                 1255                 1260             


Ile Pro  Thr Leu Tyr His Phe  Pro Thr Asn Cys Glu  Ala Cys Met 
    1265                 1270                 1275             


Lys Pro  Leu Trp His Met Phe  Lys Pro Pro Pro Ala  Leu Glu Cys 
    1280                 1285                 1290             


Arg Arg  Cys His Ile Lys Cys  His Lys Asp His Met  Asp Lys Lys 
    1295                 1300                 1305             


Glu Glu  Ile Ile Ala Pro Cys  Lys Val Tyr Tyr Asp  Ile Ser Thr 
    1310                 1315                 1320             


Ala Lys  Asn Leu Leu Leu Leu  Ala Asn Ser Thr Glu  Glu Gln Gln 
    1325                 1330                 1335             


Lys Trp  Val Ser Arg Leu Val  Lys Lys Ile Pro Lys  Lys Pro Pro 
    1340                 1345                 1350             


Ala Pro  Asp Pro Phe Ala Arg  Ser Ser Pro Arg Thr  Ser Met Lys 
    1355                 1360                 1365             


Ile Gln  Gln Asn Gln Ser Ile  Arg Arg Pro Ser Arg  Gln Leu Ala 
    1370                 1375                 1380             


Pro Asn  Lys Pro Ser 
    1385             


<210> 5
<211> 1240
<212> DNA
<213> Homo sapiens

<400> 5
cacattgttc tgatcatctg aagatcagct attagaagag aaagatcagt taagtccttt       60

ggacctgatc agcttgatac aagaactact gatttcaact tctttggctt aattctctcg      120

gaaacgatga aatatacaag ttatatcttg gcttttcagc tctgcatcgt tttgggttct      180

cttggctgtt actgccagga cccatatgta aaagaagcag aaaaccttaa gaaatatttt      240

aatgcaggtc attcagatgt agcggataat ggaactcttt tcttaggcat tttgaagaat      300

tggaaagagg agagtgacag aaaaataatg cagagccaaa ttgtctcctt ttacttcaaa      360

ctttttaaaa actttaaaga tgaccagagc atccaaaaga gtgtggagac catcaaggaa      420

gacatgaatg tcaagttttt caatagcaac aaaaagaaac gagatgactt cgaaaagctg      480

actaattatt cggtaactga cttgaatgtc caacgcaaag caatacatga actcatccaa      540

gtgatggctg aactgtcgcc agcagctaaa acagggaagc gaaaaaggag tcagatgctg      600

tttcgaggtc gaagagcatc ccagtaatgg ttgtcctgcc tgcaatattt gaattttaaa      660

tctaaatcta tttattaata tttaacatta tttatatggg gaatatattt ttagactcat      720

caatcaaata agtatttata atagcaactt ttgtgtaatg aaaatgaata tctattaata      780

tatgtattat ttataattcc tatatcctgt gactgtctca cttaatcctt tgttttctga      840

ctaattaggc aaggctatgt gattacaagg ctttatctca ggggccaact aggcagccaa      900

cctaagcaag atcccatggg ttgtgtgttt atttcacttg atgatacaat gaacacttat      960

aagtgaagtg atactatcca gttactgccg gtttgaaaat atgcctgcaa tctgagccag     1020

tgctttaatg gcatgtcaga cagaacttga atgtgtcagg tgaccctgat gaaaacatag     1080

catctcagga gatttcatgc ctggtgcttc caaatattgt tgacaactgt gactgtaccc     1140

aaatggaaag taactcattt gttaaaatta tcaatatcta atatatatga ataaagtgta     1200

agttcacaac aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                           1240


<210> 6
<211> 166
<212> PRT
<213> Homo sapiens

<400> 6
Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln 
                165     


<210> 7
<211> 4745
<212> DNA
<213> Homo sapiens

<400> 7
ttttctgccc ttctttgctt tggtggcttc cttgtggttc ctcagtggtg cctgcaaccc       60

ctggttcacc tccttccagg ttctggctcc ttccagccat ggctctcaga gtccttctgt      120

taacagcctt gaccttatgt catgggttca acttggacac tgaaaacgca atgaccttcc      180

aagagaacgc aaggggcttc gggcagagcg tggtccagct tcagggatcc agggtggtgg      240

ttggagcccc ccaggagata gtggctgcca accaaagggg cagcctctac cagtgcgact      300

acagcacagg ctcatgcgag cccatccgcc tgcaggtccc cgtggaggcc gtgaacatgt      360

ccctgggcct gtccctggca gccaccacca gcccccctca gctgctggcc tgtggtccca      420

ccgtgcacca gacttgcagt gagaacacgt atgtgaaagg gctctgcttc ctgtttggat      480

ccaacctacg gcagcagccc cagaagttcc cagaggccct ccgagggtgt cctcaagagg      540

atagtgacat tgccttcttg attgatggct ctggtagcat catcccacat gactttcggc      600

ggatgaagga gtttgtctca actgtgatgg agcaattaaa aaagtccaaa accttgttct      660

ctttgatgca gtactctgaa gaattccgga ttcactttac cttcaaagag ttccagaaca      720

accctaaccc aagatcactg gtgaagccaa taacgcagct gcttgggcgg acacacacgg      780

ccacgggcat ccgcaaagtg gtacgagagc tgtttaacat caccaacgga gcccgaaaga      840

atgcctttaa gatcctagtt gtcatcacgg atggagaaaa gtttggcgat cccttgggat      900

atgaggatgt catccctgag gcagacagag agggagtcat tcgctacgtc attggggtgg      960

gagatgcctt ccgcagtgag aaatcccgcc aagagcttaa taccatcgca tccaagccgc     1020

ctcgtgatca cgtgttccag gtgaataact ttgaggctct gaagaccatt cagaaccagc     1080

ttcgggagaa gatctttgcg atcgagggta ctcagacagg aagtagcagc tcctttgagc     1140

atgagatgtc tcaggaaggc ttcagcgctg ccatcacctc taatggcccc ttgctgagca     1200

ctgtggggag ctatgactgg gctggtggag tctttctata tacatcaaag gagaaaagca     1260

ccttcatcaa catgaccaga gtggattcag acatgaatga tgcttacttg ggttatgctg     1320

ccgccatcat cttacggaac cgggtgcaaa gcctggttct gggggcacct cgatatcagc     1380

acatcggcct ggtagcgatg ttcaggcaga acactggcat gtgggagtcc aacgctaatg     1440

tcaagggcac ccagatcggc gcctacttcg gggcctccct ctgctccgtg gacgtggaca     1500

gcaacggcag caccgacctg gtcctcatcg gggcccccca ttactacgag cagacccgag     1560

ggggccaggt gtccgtgtgc cccttgccca gggggcagag ggctcggtgg cagtgtgatg     1620

ctgttctcta cggggagcag ggccaaccct ggggccgctt tggggcagcc ctaacagtgc     1680

tgggggacgt aaatggggac aagctgacgg acgtggccat tggggcccca ggagaggagg     1740

acaaccgggg tgctgtttac ctgtttcacg gaacctcagg atctggcatc agcccctccc     1800

atagccagcg gatagcaggc tccaagctct ctcccaggct ccagtatttt ggtcagtcac     1860

tgagtggggg ccaggacctc acaatggatg gactggtaga cctgactgta ggagcccagg     1920

ggcacgtgct gctgctcagg tcccagccag tactgagagt caaggcaatc atggagttca     1980

atcccaggga agtggcaagg aatgtatttg agtgtaatga tcaggtggtg aaaggcaagg     2040

aagccggaga ggtcagagtc tgcctccatg tccagaagag cacacgggat cggctaagag     2100

aaggacagat ccagagtgtt gtgacttatg acctggctct ggactccggc cgcccacatt     2160

cccgcgccgt cttcaatgag acaaagaaca gcacacgcag acagacacag gtcttggggc     2220

tgacccagac ttgtgagacc ctgaaactac agttgccgaa ttgcatcgag gacccagtga     2280

gccccattgt gctgcgcctg aacttctctc tggtgggaac gccattgtct gctttcggga     2340

acctccggcc agtgctggcg gaggatgctc agagactctt cacagccttg tttccctttg     2400

agaagaattg tggcaatgac aacatctgcc aggatgacct cagcatcacc ttcagtttca     2460

tgagcctgga ctgcctcgtg gtgggtgggc cccgggagtt caacgtgaca gtgactgtga     2520

gaaatgatgg tgaggactcc tacaggacac aggtcacctt cttcttcccg cttgacctgt     2580

cctaccggaa ggtgtccacg ctccagaacc agcgctcaca gcgatcctgg cgcctggcct     2640

gtgagtctgc ctcctccacc gaagtgtctg gggccttgaa gagcaccagc tgcagcataa     2700

accaccccat cttcccggaa aactcagagg tcacctttaa tatcacgttt gatgtagact     2760

ctaaggcttc ccttggaaac aaactgctcc tcaaggccaa tgtgaccagt gagaacaaca     2820

tgcccagaac caacaaaacc gaattccaac tggagctgcc ggtgaaatat gctgtctaca     2880

tggtggtcac cagccatggg gtctccacta aatatctcaa cttcacggcc tcagagaata     2940

ccagtcgggt catgcagcat caatatcagg tcagcaacct ggggcagagg agcctcccca     3000

tcagcctggt gttcttggtg cccgtccggc tgaaccagac tgtcatatgg gaccgccccc     3060

aggtcacctt ctccgagaac ctctcgagta cgtgccacac caaggagcgc ttgccctctc     3120

actccgactt tctggctgag cttcggaagg cccccgtggt gaactgctcc atcgctgtct     3180

gccagagaat ccagtgtgac atcccgttct ttggcatcca ggaagaattc aatgctaccc     3240

tcaaaggcaa cctctcgttt gactggtaca tcaagacctc gcataaccac ctcctgatcg     3300

tgagcacagc tgagatcttg tttaacgatt ccgtgttcac cctgctgccg ggacaggggg     3360

cgtttgtgag gtcccagacg gagaccaaag tggagccgtt cgaggtcccc aaccccctgc     3420

cgctcatcgt gggcagctct gtcgggggac tgctgctcct ggccctcatc accgccgcgc     3480

tgtacaagct cggcttcttc aagcggcaat acaaggacat gatgagtgaa gggggtcccc     3540

cgggggccga accccagtag cggctccttc ccgacagagc tgcctctcgg tggccagcag     3600

gactctgccc agaccacacg tagcccccag gctgctggac acgtcggaca gcgaagtatc     3660

cccgacagga cgggcttggg cttccatttg tgtgtgtgca agtgtgtatg tgcgtgtgtg     3720

caagtgtctg tgtgcaagtg tgtgcacatg tgtgcgtgtg cgtgcatgtg cacttgcacg     3780

cccatgtgtg agtgtgtgca agtatgtgag tgtgtccaag tgtgtgtgcg tgtgtccatg     3840

tgtgtgcaag tgtgtgcatg tgtgcgagtg tgtgcatgtg tgtgctcagg ggcgtgtggc     3900

tcacgtgtgt gactcagatg tctctggcgt gtgggtaggt gacggcagcg tagcctctcc     3960

ggcagaaggg aactgcctgg gctcccttgt gcgtgggtga agccgctgct gggttttcct     4020

ccgggagagg ggacggtcaa tcctgtgggt gaagacagag ggaaacacag cagcttctct     4080

ccactgaaag aagtgggact tcccgtcgcc tgcgagcctg cggcctgctg gagcctgcgc     4140

agcttggatg gagactccat gagaagccgt gggtggaacc aggaacctcc tccacaccag     4200

cgctgatgcc caataaagat gcccactgag gaatgatgaa gcttcctttc tggattcatt     4260

tattatttca atgtgacttt aattttttgg atggataagc ttgtctatgg tacaaaaatc     4320

acaaggcatt caagtgtaca gtgaaaagtc tccctttcca gatattcaag tcacctcctt     4380

aaaggtagtc aagattgtgt tttgaggttt ccttcagaca gattccaggc gatgtgcaag     4440

tgtatgcacg tgtgcacaca caccacacat acacacacac aagctttttt acacaaatgg     4500

tagcatactt tatattggtc tgtatcttgc tttttttcac caatatttct cagacatcgg     4560

ttcatattaa gacataaatt actttttcat tcttttatac cgctgcatag tattccattg     4620

tgtgagtgta ccataatgta tttaaccagt cttcttttga tatactattt tcattctctt     4680

gttattgcat caatgctgag ttaataaatc aaatatatgt catttttgca tatatgtaag     4740

gataa                                                                 4745


<210> 8
<211> 1153
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala Leu Arg Val Leu Leu Leu Thr Ala Leu Thr Leu Cys His Gly 
1               5                   10                  15      


Phe Asn Leu Asp Thr Glu Asn Ala Met Thr Phe Gln Glu Asn Ala Arg 
            20                  25                  30          


Gly Phe Gly Gln Ser Val Val Gln Leu Gln Gly Ser Arg Val Val Val 
        35                  40                  45              


Gly Ala Pro Gln Glu Ile Val Ala Ala Asn Gln Arg Gly Ser Leu Tyr 
    50                  55                  60                  


Gln Cys Asp Tyr Ser Thr Gly Ser Cys Glu Pro Ile Arg Leu Gln Val 
65                  70                  75                  80  


Pro Val Glu Ala Val Asn Met Ser Leu Gly Leu Ser Leu Ala Ala Thr 
                85                  90                  95      


Thr Ser Pro Pro Gln Leu Leu Ala Cys Gly Pro Thr Val His Gln Thr 
            100                 105                 110         


Cys Ser Glu Asn Thr Tyr Val Lys Gly Leu Cys Phe Leu Phe Gly Ser 
        115                 120                 125             


Asn Leu Arg Gln Gln Pro Gln Lys Phe Pro Glu Ala Leu Arg Gly Cys 
    130                 135                 140                 


Pro Gln Glu Asp Ser Asp Ile Ala Phe Leu Ile Asp Gly Ser Gly Ser 
145                 150                 155                 160 


Ile Ile Pro His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val 
                165                 170                 175     


Met Glu Gln Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr 
            180                 185                 190         


Ser Glu Glu Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn 
        195                 200                 205             


Pro Asn Pro Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg 
    210                 215                 220                 


Thr His Thr Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn 
225                 230                 235                 240 


Ile Thr Asn Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile 
                245                 250                 255     


Thr Asp Gly Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile 
            260                 265                 270         


Pro Glu Ala Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly 
        275                 280                 285             


Asp Ala Phe Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala 
    290                 295                 300                 


Ser Lys Pro Pro Arg Asp His Val Phe Gln Val Asn Asn Phe Glu Ala 
305                 310                 315                 320 


Leu Lys Thr Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu 
                325                 330                 335     


Gly Thr Gln Thr Gly Ser Ser Ser Ser Phe Glu His Glu Met Ser Gln 
            340                 345                 350         


Glu Gly Phe Ser Ala Ala Ile Thr Ser Asn Gly Pro Leu Leu Ser Thr 
        355                 360                 365             


Val Gly Ser Tyr Asp Trp Ala Gly Gly Val Phe Leu Tyr Thr Ser Lys 
    370                 375                 380                 


Glu Lys Ser Thr Phe Ile Asn Met Thr Arg Val Asp Ser Asp Met Asn 
385                 390                 395                 400 


Asp Ala Tyr Leu Gly Tyr Ala Ala Ala Ile Ile Leu Arg Asn Arg Val 
                405                 410                 415     


Gln Ser Leu Val Leu Gly Ala Pro Arg Tyr Gln His Ile Gly Leu Val 
            420                 425                 430         


Ala Met Phe Arg Gln Asn Thr Gly Met Trp Glu Ser Asn Ala Asn Val 
        435                 440                 445             


Lys Gly Thr Gln Ile Gly Ala Tyr Phe Gly Ala Ser Leu Cys Ser Val 
    450                 455                 460                 


Asp Val Asp Ser Asn Gly Ser Thr Asp Leu Val Leu Ile Gly Ala Pro 
465                 470                 475                 480 


His Tyr Tyr Glu Gln Thr Arg Gly Gly Gln Val Ser Val Cys Pro Leu 
                485                 490                 495     


Pro Arg Gly Gln Arg Ala Arg Trp Gln Cys Asp Ala Val Leu Tyr Gly 
            500                 505                 510         


Glu Gln Gly Gln Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu 
        515                 520                 525             


Gly Asp Val Asn Gly Asp Lys Leu Thr Asp Val Ala Ile Gly Ala Pro 
    530                 535                 540                 


Gly Glu Glu Asp Asn Arg Gly Ala Val Tyr Leu Phe His Gly Thr Ser 
545                 550                 555                 560 


Gly Ser Gly Ile Ser Pro Ser His Ser Gln Arg Ile Ala Gly Ser Lys 
                565                 570                 575     


Leu Ser Pro Arg Leu Gln Tyr Phe Gly Gln Ser Leu Ser Gly Gly Gln 
            580                 585                 590         


Asp Leu Thr Met Asp Gly Leu Val Asp Leu Thr Val Gly Ala Gln Gly 
        595                 600                 605             


His Val Leu Leu Leu Arg Ser Gln Pro Val Leu Arg Val Lys Ala Ile 
    610                 615                 620                 


Met Glu Phe Asn Pro Arg Glu Val Ala Arg Asn Val Phe Glu Cys Asn 
625                 630                 635                 640 


Asp Gln Val Val Lys Gly Lys Glu Ala Gly Glu Val Arg Val Cys Leu 
                645                 650                 655     


His Val Gln Lys Ser Thr Arg Asp Arg Leu Arg Glu Gly Gln Ile Gln 
            660                 665                 670         


Ser Val Val Thr Tyr Asp Leu Ala Leu Asp Ser Gly Arg Pro His Ser 
        675                 680                 685             


Arg Ala Val Phe Asn Glu Thr Lys Asn Ser Thr Arg Arg Gln Thr Gln 
    690                 695                 700                 


Val Leu Gly Leu Thr Gln Thr Cys Glu Thr Leu Lys Leu Gln Leu Pro 
705                 710                 715                 720 


Asn Cys Ile Glu Asp Pro Val Ser Pro Ile Val Leu Arg Leu Asn Phe 
                725                 730                 735     


Ser Leu Val Gly Thr Pro Leu Ser Ala Phe Gly Asn Leu Arg Pro Val 
            740                 745                 750         


Leu Ala Glu Asp Ala Gln Arg Leu Phe Thr Ala Leu Phe Pro Phe Glu 
        755                 760                 765             


Lys Asn Cys Gly Asn Asp Asn Ile Cys Gln Asp Asp Leu Ser Ile Thr 
    770                 775                 780                 


Phe Ser Phe Met Ser Leu Asp Cys Leu Val Val Gly Gly Pro Arg Glu 
785                 790                 795                 800 


Phe Asn Val Thr Val Thr Val Arg Asn Asp Gly Glu Asp Ser Tyr Arg 
                805                 810                 815     


Thr Gln Val Thr Phe Phe Phe Pro Leu Asp Leu Ser Tyr Arg Lys Val 
            820                 825                 830         


Ser Thr Leu Gln Asn Gln Arg Ser Gln Arg Ser Trp Arg Leu Ala Cys 
        835                 840                 845             


Glu Ser Ala Ser Ser Thr Glu Val Ser Gly Ala Leu Lys Ser Thr Ser 
    850                 855                 860                 


Cys Ser Ile Asn His Pro Ile Phe Pro Glu Asn Ser Glu Val Thr Phe 
865                 870                 875                 880 


Asn Ile Thr Phe Asp Val Asp Ser Lys Ala Ser Leu Gly Asn Lys Leu 
                885                 890                 895     


Leu Leu Lys Ala Asn Val Thr Ser Glu Asn Asn Met Pro Arg Thr Asn 
            900                 905                 910         


Lys Thr Glu Phe Gln Leu Glu Leu Pro Val Lys Tyr Ala Val Tyr Met 
        915                 920                 925             


Val Val Thr Ser His Gly Val Ser Thr Lys Tyr Leu Asn Phe Thr Ala 
    930                 935                 940                 


Ser Glu Asn Thr Ser Arg Val Met Gln His Gln Tyr Gln Val Ser Asn 
945                 950                 955                 960 


Leu Gly Gln Arg Ser Leu Pro Ile Ser Leu Val Phe Leu Val Pro Val 
                965                 970                 975     


Arg Leu Asn Gln Thr Val Ile Trp Asp Arg Pro Gln Val Thr Phe Ser 
            980                 985                 990         


Glu Asn Leu Ser Ser Thr Cys His  Thr Lys Glu Arg Leu  Pro Ser His 
        995                 1000                 1005             


Ser Asp  Phe Leu Ala Glu Leu  Arg Lys Ala Pro Val  Val Asn Cys 
    1010                 1015                 1020             


Ser Ile  Ala Val Cys Gln Arg  Ile Gln Cys Asp Ile  Pro Phe Phe 
    1025                 1030                 1035             


Gly Ile  Gln Glu Glu Phe Asn  Ala Thr Leu Lys Gly  Asn Leu Ser 
    1040                 1045                 1050             


Phe Asp  Trp Tyr Ile Lys Thr  Ser His Asn His Leu  Leu Ile Val 
    1055                 1060                 1065             


Ser Thr  Ala Glu Ile Leu Phe  Asn Asp Ser Val Phe  Thr Leu Leu 
    1070                 1075                 1080             


Pro Gly  Gln Gly Ala Phe Val  Arg Ser Gln Thr Glu  Thr Lys Val 
    1085                 1090                 1095             


Glu Pro  Phe Glu Val Pro Asn  Pro Leu Pro Leu Ile  Val Gly Ser 
    1100                 1105                 1110             


Ser Val  Gly Gly Leu Leu Leu  Leu Ala Leu Ile Thr  Ala Ala Leu 
    1115                 1120                 1125             


Tyr Lys  Leu Gly Phe Phe Lys  Arg Gln Tyr Lys Asp  Met Met Ser 
    1130                 1135                 1140             


Glu Gly  Gly Pro Pro Gly Ala  Glu Pro Gln 
    1145                 1150             


<210> 9
<211> 4190
<212> DNA
<213> Homo sapiens

<400> 9
atatgtagcc ttttcatttt catgaaagtg aagtgatttt tagaattctt agttgttttc       60

tttagaagaa catttctagg gaataataca agaagattta ggaatcattg aagttataaa      120

tctttggaat gagcaaactc agaatggtgc tacttgaaga ctctggatct gctgacttca      180

gaagacattt tgtcaacttg agtcccttca ccattactgt ggtcttactt ctcagtgcct      240

gttttgtcac cagttctctt ggaggaacag acaaggagct gaggctagtg gatggtgaaa      300

acaagtgtag cgggagagtg gaagtgaaag tccaggagga gtggggaacg gtgtgtaata      360

atggctggag catggaagcg gtctctgtga tttgtaacca gctgggatgt ccaactgcta      420

tcaaagcccc tggatgggct aattccagtg caggttctgg acgcatttgg atggatcatg      480

tttcttgtcg tgggaatgag tcagctcttt gggattgcaa acatgatgga tggggaaagc      540

atagtaactg tactcaccaa caagatgctg gagtgacctg ctcagatgga tccaatttgg      600

aaatgaggct gacgcgtgga gggaatatgt gttctggaag aatagagatc aaattccaag      660

gacggtgggg aacagtgtgt gatgataact tcaacataga tcatgcatct gtcatttgta      720

gacaacttga atgtggaagt gctgtcagtt tctctggttc atctaatttt ggagaaggct      780

ctggaccaat ctggtttgat gatcttatat gcaacggaaa tgagtcagct ctctggaact      840

gcaaacatca aggatgggga aagcataact gtgatcatgc tgaggatgct ggagtgattt      900

gctcaaaggg agcagatctg agcctgagac tggtagatgg agtcactgaa tgttcaggaa      960

gattagaagt gagattccaa ggagaatggg ggacaatatg tgatgacggc tgggacagtt     1020

acgatgctgc tgtggcatgc aagcaactgg gatgtccaac tgccgtcaca gccattggtc     1080

gagttaacgc cagtaaggga tttggacaca tctggcttga cagcgtttct tgccagggac     1140

atgaacctgc tatctggcaa tgtaaacacc atgaatgggg aaagcattat tgcaatcaca     1200

atgaagatgc tggcgtgaca tgttctgatg gatcagatct ggagctaaga cttagaggtg     1260

gaggcagccg ctgtgctggg acagttgagg tggagattca gagactgtta gggaaggtgt     1320

gtgacagagg ctggggactg aaagaagctg atgtggtttg caggcagctg ggatgtggat     1380

ctgcactcaa aacatcttat caagtgtact ccaaaatcca ggcaacaaac acatggctgt     1440

ttctaagtag ctgtaacgga aatgaaactt ctctttggga ctgcaagaac tggcaatggg     1500

gtggacttac ctgtgatcac tatgaagaag ccaaaattac ctgctcagcc cacagggaac     1560

ccagactggt tggaggggac attccctgtt ctggacgtgt tgaagtgaag catggtgaca     1620

cgtggggctc catctgtgat tcggacttct ctctggaagc tgccagcgtt ctatgcaggg     1680

aattacagtg tggcacagtt gtctctatcc tggggggagc tcactttgga gagggaaatg     1740

gacagatctg ggctgaagaa ttccagtgtg agggacatga gtcccatctt tcactctgcc     1800

cagtagcacc ccgcccagaa ggaacttgta gccacagcag ggatgttgga gtagtctgct     1860

caagatacac agaaattcgc ttggtgaatg gcaagacccc gtgtgagggc agagtggagc     1920

tcaaaacgct tggtgcctgg ggatccctct gtaactctca ctgggacata gaagatgccc     1980

atgttctttg ccagcagctt aaatgtggag ttgccctttc taccccagga ggagcacgtt     2040

ttggaaaagg aaatggtcag atctggaggc atatgtttca ctgcactggg actgagcagc     2100

acatgggaga ttgtcctgta actgctctag gtgcttcatt atgtccttca gagcaagtgg     2160

cctctgtaat ctgctcagga aaccagtccc aaacactgtc ctcgtgcaat tcatcgtctt     2220

tgggcccaac aaggcctacc attccagaag aaagtgctgt ggcctgcata gagagtggtc     2280

aacttcgcct ggtaaatgga ggaggtcgct gtgctgggag agtagagatc tatcatgagg     2340

gctcctgggg caccatctgt gatgacagct gggacctgag tgatgcccac gtggtttgca     2400

gacagctggg ctgtggagag gccattaatg ccactggttc tgctcatttt ggggaaggaa     2460

cagggcccat ctggctggat gagatgaaat gcaatggaaa agaatcccgc atttggcagt     2520

gccattcaca cggctggggg cagcaaaatt gcaggcacaa ggaggatgcg ggagttatct     2580

gctcagaatt catgtctctg agactgacca gtgaagccag cagagaggcc tgtgcagggc     2640

gtctggaagt tttttacaat ggagcttggg gcactgttgg caagagtagc atgtctgaaa     2700

ccactgtggg tgtggtgtgc aggcagctgg gctgtgcaga caaagggaaa atcaaccctg     2760

catctttaga caaggccatg tccattccca tgtgggtgga caatgttcag tgtccaaaag     2820

gacctgacac gctgtggcag tgcccatcat ctccatggga gaagagactg gccagcccct     2880

cggaggagac ctggatcaca tgtgacaaca agataagact tcaggaagga cccacttcct     2940

gttctggacg tgtggagatc tggcatggag gttcctgggg gacagtgtgt gatgactctt     3000

gggacttgga cgatgctcag gtggtgtgtc aacaacttgg ctgtggtcca gctttgaaag     3060

cattcaaaga agcagagttt ggtcagggga ctggaccgat atggctcaat gaagtgaagt     3120

gcaaagggaa tgagtcttcc ttgtgggatt gtcctgccag acgctggggc catagtgagt     3180

gtgggcacaa ggaagacgct gcagtgaatt gcacagatat ttcagtgcag aaaaccccac     3240

aaaaagccac aacaggtcgc tcatcccgtc agtcatcctt tattgcagtc gggatccttg     3300

gggttgttct gttggccatt ttcgtcgcat tattcttctt gactaaaaag cgaagacaga     3360

gacagcggct tgcagtttcc tcaagaggag agaacttagt ccaccaaatt caataccggg     3420

agatgaattc ttgcctgaat gcagatgatc tggacctaat gaattcctca gaaaattccc     3480

atgagtcagc tgatttcagt gctgctgaac taatttctgt gtctaaattt cttcctattt     3540

ctggaatgga aaaggaggcc attctgagcc acactgaaaa ggaaaatggg aatttataac     3600

ccagtgagtt cagcctttaa gataccttga tgaagacctg gactattgaa tggagcagaa     3660

attcacctct ctcactgact attacagttg catttttatg gagttcttct tctcctagga     3720

ttcctaagac tgctgctgaa tttataaaaa ttaagtttgt gaatgtgact acttagtggt     3780

gtatatgaga ctttcaaggg aattaaataa ataaataaga atgttattga tttgagtttg     3840

ctttaattac ttgtccttaa ttctattaat ttctaaatgg gcttcctaat tttttgtaga     3900

gtttcctaga tgtattataa tgtgttttat ttgacagtgt ttcaatttgc atatacagta     3960

ctgtatattt tttcttattt ggtttgaata attttcctat taccaaataa aaataaattt     4020

atttttactt tagtttttct aagacaggaa aagttaatga tattgaaggg tctgtaaata     4080

atatatggct aactttataa ggcatgactc acaacgattc tttaactgct ttttgttact     4140

gtaattctgt tcactagaat aaaatgcaga gccacacctg gtgagggcac                4190


<210> 10
<211> 1156
<212> PRT
<213> Homo sapiens

<400> 10
Met Ser Lys Leu Arg Met Val Leu Leu Glu Asp Ser Gly Ser Ala Asp 
1               5                   10                  15      


Phe Arg Arg His Phe Val Asn Leu Ser Pro Phe Thr Ile Thr Val Val 
            20                  25                  30          


Leu Leu Leu Ser Ala Cys Phe Val Thr Ser Ser Leu Gly Gly Thr Asp 
        35                  40                  45              


Lys Glu Leu Arg Leu Val Asp Gly Glu Asn Lys Cys Ser Gly Arg Val 
    50                  55                  60                  


Glu Val Lys Val Gln Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp 
65                  70                  75                  80  


Ser Met Glu Ala Val Ser Val Ile Cys Asn Gln Leu Gly Cys Pro Thr 
                85                  90                  95      


Ala Ile Lys Ala Pro Gly Trp Ala Asn Ser Ser Ala Gly Ser Gly Arg 
            100                 105                 110         


Ile Trp Met Asp His Val Ser Cys Arg Gly Asn Glu Ser Ala Leu Trp 
        115                 120                 125             


Asp Cys Lys His Asp Gly Trp Gly Lys His Ser Asn Cys Thr His Gln 
    130                 135                 140                 


Gln Asp Ala Gly Val Thr Cys Ser Asp Gly Ser Asn Leu Glu Met Arg 
145                 150                 155                 160 


Leu Thr Arg Gly Gly Asn Met Cys Ser Gly Arg Ile Glu Ile Lys Phe 
                165                 170                 175     


Gln Gly Arg Trp Gly Thr Val Cys Asp Asp Asn Phe Asn Ile Asp His 
            180                 185                 190         


Ala Ser Val Ile Cys Arg Gln Leu Glu Cys Gly Ser Ala Val Ser Phe 
        195                 200                 205             


Ser Gly Ser Ser Asn Phe Gly Glu Gly Ser Gly Pro Ile Trp Phe Asp 
    210                 215                 220                 


Asp Leu Ile Cys Asn Gly Asn Glu Ser Ala Leu Trp Asn Cys Lys His 
225                 230                 235                 240 


Gln Gly Trp Gly Lys His Asn Cys Asp His Ala Glu Asp Ala Gly Val 
                245                 250                 255     


Ile Cys Ser Lys Gly Ala Asp Leu Ser Leu Arg Leu Val Asp Gly Val 
            260                 265                 270         


Thr Glu Cys Ser Gly Arg Leu Glu Val Arg Phe Gln Gly Glu Trp Gly 
        275                 280                 285             


Thr Ile Cys Asp Asp Gly Trp Asp Ser Tyr Asp Ala Ala Val Ala Cys 
    290                 295                 300                 


Lys Gln Leu Gly Cys Pro Thr Ala Val Thr Ala Ile Gly Arg Val Asn 
305                 310                 315                 320 


Ala Ser Lys Gly Phe Gly His Ile Trp Leu Asp Ser Val Ser Cys Gln 
                325                 330                 335     


Gly His Glu Pro Ala Ile Trp Gln Cys Lys His His Glu Trp Gly Lys 
            340                 345                 350         


His Tyr Cys Asn His Asn Glu Asp Ala Gly Val Thr Cys Ser Asp Gly 
        355                 360                 365             


Ser Asp Leu Glu Leu Arg Leu Arg Gly Gly Gly Ser Arg Cys Ala Gly 
    370                 375                 380                 


Thr Val Glu Val Glu Ile Gln Arg Leu Leu Gly Lys Val Cys Asp Arg 
385                 390                 395                 400 


Gly Trp Gly Leu Lys Glu Ala Asp Val Val Cys Arg Gln Leu Gly Cys 
                405                 410                 415     


Gly Ser Ala Leu Lys Thr Ser Tyr Gln Val Tyr Ser Lys Ile Gln Ala 
            420                 425                 430         


Thr Asn Thr Trp Leu Phe Leu Ser Ser Cys Asn Gly Asn Glu Thr Ser 
        435                 440                 445             


Leu Trp Asp Cys Lys Asn Trp Gln Trp Gly Gly Leu Thr Cys Asp His 
    450                 455                 460                 


Tyr Glu Glu Ala Lys Ile Thr Cys Ser Ala His Arg Glu Pro Arg Leu 
465                 470                 475                 480 


Val Gly Gly Asp Ile Pro Cys Ser Gly Arg Val Glu Val Lys His Gly 
                485                 490                 495     


Asp Thr Trp Gly Ser Ile Cys Asp Ser Asp Phe Ser Leu Glu Ala Ala 
            500                 505                 510         


Ser Val Leu Cys Arg Glu Leu Gln Cys Gly Thr Val Val Ser Ile Leu 
        515                 520                 525             


Gly Gly Ala His Phe Gly Glu Gly Asn Gly Gln Ile Trp Ala Glu Glu 
    530                 535                 540                 


Phe Gln Cys Glu Gly His Glu Ser His Leu Ser Leu Cys Pro Val Ala 
545                 550                 555                 560 


Pro Arg Pro Glu Gly Thr Cys Ser His Ser Arg Asp Val Gly Val Val 
                565                 570                 575     


Cys Ser Arg Tyr Thr Glu Ile Arg Leu Val Asn Gly Lys Thr Pro Cys 
            580                 585                 590         


Glu Gly Arg Val Glu Leu Lys Thr Leu Gly Ala Trp Gly Ser Leu Cys 
        595                 600                 605             


Asn Ser His Trp Asp Ile Glu Asp Ala His Val Leu Cys Gln Gln Leu 
    610                 615                 620                 


Lys Cys Gly Val Ala Leu Ser Thr Pro Gly Gly Ala Arg Phe Gly Lys 
625                 630                 635                 640 


Gly Asn Gly Gln Ile Trp Arg His Met Phe His Cys Thr Gly Thr Glu 
                645                 650                 655     


Gln His Met Gly Asp Cys Pro Val Thr Ala Leu Gly Ala Ser Leu Cys 
            660                 665                 670         


Pro Ser Glu Gln Val Ala Ser Val Ile Cys Ser Gly Asn Gln Ser Gln 
        675                 680                 685             


Thr Leu Ser Ser Cys Asn Ser Ser Ser Leu Gly Pro Thr Arg Pro Thr 
    690                 695                 700                 


Ile Pro Glu Glu Ser Ala Val Ala Cys Ile Glu Ser Gly Gln Leu Arg 
705                 710                 715                 720 


Leu Val Asn Gly Gly Gly Arg Cys Ala Gly Arg Val Glu Ile Tyr His 
                725                 730                 735     


Glu Gly Ser Trp Gly Thr Ile Cys Asp Asp Ser Trp Asp Leu Ser Asp 
            740                 745                 750         


Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Glu Ala Ile Asn Ala 
        755                 760                 765             


Thr Gly Ser Ala His Phe Gly Glu Gly Thr Gly Pro Ile Trp Leu Asp 
    770                 775                 780                 


Glu Met Lys Cys Asn Gly Lys Glu Ser Arg Ile Trp Gln Cys His Ser 
785                 790                 795                 800 


His Gly Trp Gly Gln Gln Asn Cys Arg His Lys Glu Asp Ala Gly Val 
                805                 810                 815     


Ile Cys Ser Glu Phe Met Ser Leu Arg Leu Thr Ser Glu Ala Ser Arg 
            820                 825                 830         


Glu Ala Cys Ala Gly Arg Leu Glu Val Phe Tyr Asn Gly Ala Trp Gly 
        835                 840                 845             


Thr Val Gly Lys Ser Ser Met Ser Glu Thr Thr Val Gly Val Val Cys 
    850                 855                 860                 


Arg Gln Leu Gly Cys Ala Asp Lys Gly Lys Ile Asn Pro Ala Ser Leu 
865                 870                 875                 880 


Asp Lys Ala Met Ser Ile Pro Met Trp Val Asp Asn Val Gln Cys Pro 
                885                 890                 895     


Lys Gly Pro Asp Thr Leu Trp Gln Cys Pro Ser Ser Pro Trp Glu Lys 
            900                 905                 910         


Arg Leu Ala Ser Pro Ser Glu Glu Thr Trp Ile Thr Cys Asp Asn Lys 
        915                 920                 925             


Ile Arg Leu Gln Glu Gly Pro Thr Ser Cys Ser Gly Arg Val Glu Ile 
    930                 935                 940                 


Trp His Gly Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Leu 
945                 950                 955                 960 


Asp Asp Ala Gln Val Val Cys Gln Gln Leu Gly Cys Gly Pro Ala Leu 
                965                 970                 975     


Lys Ala Phe Lys Glu Ala Glu Phe Gly Gln Gly Thr Gly Pro Ile Trp 
            980                 985                 990         


Leu Asn Glu Val Lys Cys Lys Gly  Asn Glu Ser Ser Leu  Trp Asp Cys 
        995                 1000                 1005             


Pro Ala  Arg Arg Trp Gly His  Ser Glu Cys Gly His  Lys Glu Asp 
    1010                 1015                 1020             


Ala Ala  Val Asn Cys Thr Asp  Ile Ser Val Gln Lys  Thr Pro Gln 
    1025                 1030                 1035             


Lys Ala  Thr Thr Gly Arg Ser  Ser Arg Gln Ser Ser  Phe Ile Ala 
    1040                 1045                 1050             


Val Gly  Ile Leu Gly Val Val  Leu Leu Ala Ile Phe  Val Ala Leu 
    1055                 1060                 1065             


Phe Phe  Leu Thr Lys Lys Arg  Arg Gln Arg Gln Arg  Leu Ala Val 
    1070                 1075                 1080             


Ser Ser  Arg Gly Glu Asn Leu  Val His Gln Ile Gln  Tyr Arg Glu 
    1085                 1090                 1095             


Met Asn  Ser Cys Leu Asn Ala  Asp Asp Leu Asp Leu  Met Asn Ser 
    1100                 1105                 1110             


Ser Glu  Asn Ser His Glu Ser  Ala Asp Phe Ser Ala  Ala Glu Leu 
    1115                 1120                 1125             


Ile Ser  Val Ser Lys Phe Leu  Pro Ile Ser Gly Met  Glu Lys Glu 
    1130                 1135                 1140             


Ala Ile  Leu Ser His Thr Glu  Lys Glu Asn Gly Asn  Leu 
    1145                 1150                 1155     


<210> 11
<211> 5205
<212> DNA
<213> Homo sapiens

<400> 11
cttttcagct gggcagctct gggaacttgg attaggtgga gaggcagttg gggggcctcg       60

ttgttttgcg tcttagttcc gccctcctgt ccatcaggag aaggaaagga taaaccctgg      120

gccatgaggc tacccctgct cctggttttt gcctctgtca ttccgggtgc tgttctccta      180

ctggacacca ggcaattttt aatctataat gaagatcaca agcgctgcgt ggatgcagtg      240

agtcccagtg ccgtccaaac cgcagcttgc aaccaggatg ccgaatcaca gaaattccga      300

tgggtgtccg aatctcagat tatgagtgtt gcatttaaat tatgcctggg agtgccatca      360

aaaacggact gggttgctat cactctctat gcctgtgact caaaaagtga atttcagaaa      420

tgggagtgca aaaatgacac acttttgggg atcaaaggag aagatttatt ttttaactac      480

ggcaacagac aagaaaagaa tattatgctc tacaagggat cgggtttatg gagcaggtgg      540

aagatctatg gaaccacaga caatctgtgc tccagaggtt atgaagccat gtatacgcta      600

ctaggcaatg ccaatggagc aacctgtgca ttcccgttca agtttgaaaa caagtggtac      660

gcagattgca cgagtgctgg gcggtcggat ggatggctct ggtgcggaac cactactgac      720

tatgacacag acaagctatt tggatattgt ccattgaaat ttgagggcag tgaaagctta      780

tggaataaag acccgctgac cagcgtttcc taccagataa actccaaatc cgctttaacg      840

tggcaccagg cgaggaaaag ctgccaacaa cagaacgctg agctcctgag catcacagag      900

attcatgagc aaacatacct gacaggatta accagttcct tgacctcagg actctggatt      960

ggacttaaca gtctgagctt caacagcggt tggcagtgga gtgaccgcag tcctttccga     1020

tatttgaact ggttaccagg aagtccatca gctgaacctg gaaaaagctg tgtgtcacta     1080

aatcctggaa aaaatgctaa atgggaaaat ctggaatgtg ttcagaaact gggctatatt     1140

tgcaaaaagg gcaacaccac tttaaattct tttgttattc cctcagaaag tgatgtgcct     1200

actcactgtc ctagtcagtg gtggccgtat gccggtcact gttacaagat tcacagagat     1260

gagaaaaaaa tccagaggga tgctctgacc acctgcagga aggaaggcgg tgacctcaca     1320

agtatccaca ccatcgagga attggacttt attatctccc agctaggata tgagccaaat     1380

gacgaattgt ggatcggctt aaatgacatt aagattcaaa tgtactttga gtggagtgat     1440

gggacccctg taacgtttac caaatggctt cgtggagaac caagccatga aaacaacaga     1500

caggaggatt gtgtggtgat gaaaggcaag gatgggtact gggcagatcg gggctgtgag     1560

tggcctcttg gctacatctg caagatgaaa tcacgaagcc aaggtccaga aatagtggaa     1620

gtcgaaaaag gctgcaggaa aggctggaaa aaacatcact tttactgcta tatgattgga     1680

catacgcttt caacatttgc agaagcaaac caaacctgta ataatgagaa tgcttattta     1740

acaactattg aagacagata tgaacaagcc ttcctgacta gtttcgttgg cttaaggcct     1800

gaaaaatatt tctggacagg actttcagat atacaaacca aagggacttt tcagtggacc     1860

atcgaggaag aggttcggtt cacccactgg aattcagata tgccagggcg aaagccaggg     1920

tgtgttgcca tgagaaccgg gattgcaggg ggcttatggg atgttttgaa atgtgatgaa     1980

aaggcaaaat ttgtgtgcaa gcactgggca gaaggagtaa cccacccacc gaagcccacg     2040

acgactcccg aacccaaatg tccggaggat tggggcgcca gcagtagaac aagcttgtgt     2100

ttcaagctgt atgcaaaagg aaaacatgag aagaaaacgt ggtttgaatc tcgagatttt     2160

tgtcgagctc tgggtggaga cttagctagc atcaataaca aagaggaaca gcaaacaata     2220

tggcgattaa taacagctag tggaagctac cacaaactgt tttggttggg attgacatat     2280

ggaagccctt cagaaggttt tacttggagt gatggttctc ctgtttcata tgaaaactgg     2340

gcttatggag aacctaataa ttatcaaaat gttgaatact gtggtgagct gaaaggtgac     2400

cctactatgt cttggaatga tattaattgt gaacacctta acaactggat ttgccagata     2460

caaaaaggac aaacaccaaa acctgagcca acaccagctc ctcaagacaa tccaccagtt     2520

actgaagatg ggtgggttat ttacaaagac taccagtatt atttcagcaa agagaaggaa     2580

accatggaca atgcgcgagc gttttgcaag aggaattttg gtgatcttgt ttctattcaa     2640

agtgaaagtg aaaagaagtt tctatggaaa tatgtaaaca gaaatgatgc acagtctgca     2700

tattttattg gtttattgat cagcttggat aaaaagtttg cttggatgga tggaagcaaa     2760

gtggattacg tgtcttgggc cacaggtgaa cccaattttg caaatgaaga tgaaaactgt     2820

gtgaccatgt attcaaattc agggttttgg aatgacatta actgtggcta tccaaacgcc     2880

ttcatttgcc agcgacataa cagtagtatc aatgctacca cagttatgcc taccatgccc     2940

tcggtcccat cagggtgcaa ggaaggttgg aatttctaca gcaacaagtg tttcaaaatc     3000

tttggattta tggaagaaga aagaaaaaat tggcaagagg cacgaaaagc ttgtataggc     3060

tttggaggga atctggtctc catacaaaat gaaaaagagc aagcatttct tacctatcac     3120

atgaaggact ccactttcag tgcctggact gggctgaatg atgtcaattc agaacacacg     3180

ttcctttgga cggatggacg aggagtccat tacacaaact gggggaaagg ttaccctggt     3240

ggaagaagaa gcagtctttc ttatgaagat gctgactgtg ttgttattat tggaggtgca     3300

tcaaatgaag caggaaaatg gatggatgat acctgcgaca gtaaacgagg ctacatatgc     3360

cagacacgat ccgacccttc cttgactaat cctccagcaa cgattcaaac agatggcttt     3420

gttaaatatg gcaaaagcag ctattcactc atgagacaaa aatttcaatg gcatgaagcg     3480

gagacatact gcaagcttca caattccctt atagccagca ttctggatcc ctacagtaat     3540

gcatttgcgt ggctgcagat ggaaacatct aatgaacgtg tgtggatcgc cctgaacagt     3600

aacttgactg ataatcaata cacttggact gataagtgga gggtgaggta cactaactgg     3660

gctgctgatg agcccaaatt gaaatcagca tgtgtttatc tggatcttga tggctactgg     3720

aagacagcac attgcaatga aagtttttac tttctctgta aaagatcaga tgaaatccct     3780

gctactgaac ccccacaact gcctggcaga tgcccggagt cagatcacac agcatggatt     3840

cctttccatg gtcactgtta ctatattgag tcctcatata caagaaactg gggccaagct     3900

tctctggaat gtcttcgaat gggttcctct ctggtttcca ttgaaagtgc tgcagaatcc     3960

agttttctgt catatcgggt tgagccactt aaaagtaaaa ccaatttttg gataggattg     4020

ttcagaaatg ttgaagggac gtggctgtgg ataaataaca gtccggtctc ctttgtcaac     4080

tggaacacag gagatccctc tggtgaacgg aatgattgtg tagctttaca tgcgtcttct     4140

gggttttgga gtaatattca ctgttcatcc tacaaaggat atatttgtaa aagaccaaaa     4200

attattgatg ctaaacctac tcatgaatta cttacaacaa aagctgacac aaggaagatg     4260

gacccttcta aaccgtcttc caacgtggcc ggagtagtca tcattgtgat cctcctgatt     4320

ttaacgggtg ctggccttgc cgcctatttc ttttataaga aaagacgtgt gcacctacct     4380

caagagggcg cctttgaaaa cactctgtat tttaacagtc agtcaagccc aggaactagt     4440

gatatgaaag atctcgtggg caatattgaa cagaatgaac actcggtcat ctagtacctc     4500

aatgcgattc tgagatattt gaatttcata aaattgtaac tgaaatttaa aatttttagt     4560

tcaatgtgat tgttttcttt aaaatgagta ctgaattgta ctggtctgtc cttttttcct     4620

ttgcctaatt gaagaaataa ttgcttgttt tctagcctgg caagatattt tcataaaaga     4680

gggataacaa tgctgattac taccttttaa aatattttag ataaatgcac agcaccacag     4740

caccacatct aagcattagt gatgggtagc tgatgtcagc ttcatgtgga ttttaagcac     4800

tctagaaaca atgaagcttc ttggcatatt ttaaggagct cccaaaatgt gttacctatt     4860

aaattgtaac tcagcaagta gaagaccatt tgaaaagtca ggtacaaatt tcctcaagtg     4920

gcataaaaat gtagtcagtt ttctctttta ccagttttta tttccactcc aattatttag     4980

aactttattt gtacatgtgc agaagaataa ggcagctgag aatcttgttt cccccaagag     5040

agttttacag gctgagtgtt gcaaatgtgt tctttgtcct gttatatgta tatcaggaat     5100

acaaggatgt gaaataaaac tgtaaatttg cataactgga tgtacttaga taatgtgaaa     5160

taaacattaa agacaaggtc tatttttaat aaaaaaaaaa aaaaa                     5205


<210> 12
<211> 1456
<212> PRT
<213> Homo sapiens

<400> 12
Met Arg Leu Pro Leu Leu Leu Val Phe Ala Ser Val Ile Pro Gly Ala 
1               5                   10                  15      


Val Leu Leu Leu Asp Thr Arg Gln Phe Leu Ile Tyr Asn Glu Asp His 
            20                  25                  30          


Lys Arg Cys Val Asp Ala Val Ser Pro Ser Ala Val Gln Thr Ala Ala 
        35                  40                  45              


Cys Asn Gln Asp Ala Glu Ser Gln Lys Phe Arg Trp Val Ser Glu Ser 
    50                  55                  60                  


Gln Ile Met Ser Val Ala Phe Lys Leu Cys Leu Gly Val Pro Ser Lys 
65                  70                  75                  80  


Thr Asp Trp Val Ala Ile Thr Leu Tyr Ala Cys Asp Ser Lys Ser Glu 
                85                  90                  95      


Phe Gln Lys Trp Glu Cys Lys Asn Asp Thr Leu Leu Gly Ile Lys Gly 
            100                 105                 110         


Glu Asp Leu Phe Phe Asn Tyr Gly Asn Arg Gln Glu Lys Asn Ile Met 
        115                 120                 125             


Leu Tyr Lys Gly Ser Gly Leu Trp Ser Arg Trp Lys Ile Tyr Gly Thr 
    130                 135                 140                 


Thr Asp Asn Leu Cys Ser Arg Gly Tyr Glu Ala Met Tyr Thr Leu Leu 
145                 150                 155                 160 


Gly Asn Ala Asn Gly Ala Thr Cys Ala Phe Pro Phe Lys Phe Glu Asn 
                165                 170                 175     


Lys Trp Tyr Ala Asp Cys Thr Ser Ala Gly Arg Ser Asp Gly Trp Leu 
            180                 185                 190         


Trp Cys Gly Thr Thr Thr Asp Tyr Asp Thr Asp Lys Leu Phe Gly Tyr 
        195                 200                 205             


Cys Pro Leu Lys Phe Glu Gly Ser Glu Ser Leu Trp Asn Lys Asp Pro 
    210                 215                 220                 


Leu Thr Ser Val Ser Tyr Gln Ile Asn Ser Lys Ser Ala Leu Thr Trp 
225                 230                 235                 240 


His Gln Ala Arg Lys Ser Cys Gln Gln Gln Asn Ala Glu Leu Leu Ser 
                245                 250                 255     


Ile Thr Glu Ile His Glu Gln Thr Tyr Leu Thr Gly Leu Thr Ser Ser 
            260                 265                 270         


Leu Thr Ser Gly Leu Trp Ile Gly Leu Asn Ser Leu Ser Phe Asn Ser 
        275                 280                 285             


Gly Trp Gln Trp Ser Asp Arg Ser Pro Phe Arg Tyr Leu Asn Trp Leu 
    290                 295                 300                 


Pro Gly Ser Pro Ser Ala Glu Pro Gly Lys Ser Cys Val Ser Leu Asn 
305                 310                 315                 320 


Pro Gly Lys Asn Ala Lys Trp Glu Asn Leu Glu Cys Val Gln Lys Leu 
                325                 330                 335     


Gly Tyr Ile Cys Lys Lys Gly Asn Thr Thr Leu Asn Ser Phe Val Ile 
            340                 345                 350         


Pro Ser Glu Ser Asp Val Pro Thr His Cys Pro Ser Gln Trp Trp Pro 
        355                 360                 365             


Tyr Ala Gly His Cys Tyr Lys Ile His Arg Asp Glu Lys Lys Ile Gln 
    370                 375                 380                 


Arg Asp Ala Leu Thr Thr Cys Arg Lys Glu Gly Gly Asp Leu Thr Ser 
385                 390                 395                 400 


Ile His Thr Ile Glu Glu Leu Asp Phe Ile Ile Ser Gln Leu Gly Tyr 
                405                 410                 415     


Glu Pro Asn Asp Glu Leu Trp Ile Gly Leu Asn Asp Ile Lys Ile Gln 
            420                 425                 430         


Met Tyr Phe Glu Trp Ser Asp Gly Thr Pro Val Thr Phe Thr Lys Trp 
        435                 440                 445             


Leu Arg Gly Glu Pro Ser His Glu Asn Asn Arg Gln Glu Asp Cys Val 
    450                 455                 460                 


Val Met Lys Gly Lys Asp Gly Tyr Trp Ala Asp Arg Gly Cys Glu Trp 
465                 470                 475                 480 


Pro Leu Gly Tyr Ile Cys Lys Met Lys Ser Arg Ser Gln Gly Pro Glu 
                485                 490                 495     


Ile Val Glu Val Glu Lys Gly Cys Arg Lys Gly Trp Lys Lys His His 
            500                 505                 510         


Phe Tyr Cys Tyr Met Ile Gly His Thr Leu Ser Thr Phe Ala Glu Ala 
        515                 520                 525             


Asn Gln Thr Cys Asn Asn Glu Asn Ala Tyr Leu Thr Thr Ile Glu Asp 
    530                 535                 540                 


Arg Tyr Glu Gln Ala Phe Leu Thr Ser Phe Val Gly Leu Arg Pro Glu 
545                 550                 555                 560 


Lys Tyr Phe Trp Thr Gly Leu Ser Asp Ile Gln Thr Lys Gly Thr Phe 
                565                 570                 575     


Gln Trp Thr Ile Glu Glu Glu Val Arg Phe Thr His Trp Asn Ser Asp 
            580                 585                 590         


Met Pro Gly Arg Lys Pro Gly Cys Val Ala Met Arg Thr Gly Ile Ala 
        595                 600                 605             


Gly Gly Leu Trp Asp Val Leu Lys Cys Asp Glu Lys Ala Lys Phe Val 
    610                 615                 620                 


Cys Lys His Trp Ala Glu Gly Val Thr His Pro Pro Lys Pro Thr Thr 
625                 630                 635                 640 


Thr Pro Glu Pro Lys Cys Pro Glu Asp Trp Gly Ala Ser Ser Arg Thr 
                645                 650                 655     


Ser Leu Cys Phe Lys Leu Tyr Ala Lys Gly Lys His Glu Lys Lys Thr 
            660                 665                 670         


Trp Phe Glu Ser Arg Asp Phe Cys Arg Ala Leu Gly Gly Asp Leu Ala 
        675                 680                 685             


Ser Ile Asn Asn Lys Glu Glu Gln Gln Thr Ile Trp Arg Leu Ile Thr 
    690                 695                 700                 


Ala Ser Gly Ser Tyr His Lys Leu Phe Trp Leu Gly Leu Thr Tyr Gly 
705                 710                 715                 720 


Ser Pro Ser Glu Gly Phe Thr Trp Ser Asp Gly Ser Pro Val Ser Tyr 
                725                 730                 735     


Glu Asn Trp Ala Tyr Gly Glu Pro Asn Asn Tyr Gln Asn Val Glu Tyr 
            740                 745                 750         


Cys Gly Glu Leu Lys Gly Asp Pro Thr Met Ser Trp Asn Asp Ile Asn 
        755                 760                 765             


Cys Glu His Leu Asn Asn Trp Ile Cys Gln Ile Gln Lys Gly Gln Thr 
    770                 775                 780                 


Pro Lys Pro Glu Pro Thr Pro Ala Pro Gln Asp Asn Pro Pro Val Thr 
785                 790                 795                 800 


Glu Asp Gly Trp Val Ile Tyr Lys Asp Tyr Gln Tyr Tyr Phe Ser Lys 
                805                 810                 815     


Glu Lys Glu Thr Met Asp Asn Ala Arg Ala Phe Cys Lys Arg Asn Phe 
            820                 825                 830         


Gly Asp Leu Val Ser Ile Gln Ser Glu Ser Glu Lys Lys Phe Leu Trp 
        835                 840                 845             


Lys Tyr Val Asn Arg Asn Asp Ala Gln Ser Ala Tyr Phe Ile Gly Leu 
    850                 855                 860                 


Leu Ile Ser Leu Asp Lys Lys Phe Ala Trp Met Asp Gly Ser Lys Val 
865                 870                 875                 880 


Asp Tyr Val Ser Trp Ala Thr Gly Glu Pro Asn Phe Ala Asn Glu Asp 
                885                 890                 895     


Glu Asn Cys Val Thr Met Tyr Ser Asn Ser Gly Phe Trp Asn Asp Ile 
            900                 905                 910         


Asn Cys Gly Tyr Pro Asn Ala Phe Ile Cys Gln Arg His Asn Ser Ser 
        915                 920                 925             


Ile Asn Ala Thr Thr Val Met Pro Thr Met Pro Ser Val Pro Ser Gly 
    930                 935                 940                 


Cys Lys Glu Gly Trp Asn Phe Tyr Ser Asn Lys Cys Phe Lys Ile Phe 
945                 950                 955                 960 


Gly Phe Met Glu Glu Glu Arg Lys Asn Trp Gln Glu Ala Arg Lys Ala 
                965                 970                 975     


Cys Ile Gly Phe Gly Gly Asn Leu Val Ser Ile Gln Asn Glu Lys Glu 
            980                 985                 990         


Gln Ala Phe Leu Thr Tyr His Met  Lys Asp Ser Thr Phe  Ser Ala Trp 
        995                 1000                 1005             


Thr Gly  Leu Asn Asp Val Asn  Ser Glu His Thr Phe  Leu Trp Thr 
    1010                 1015                 1020             


Asp Gly  Arg Gly Val His Tyr  Thr Asn Trp Gly Lys  Gly Tyr Pro 
    1025                 1030                 1035             


Gly Gly  Arg Arg Ser Ser Leu  Ser Tyr Glu Asp Ala  Asp Cys Val 
    1040                 1045                 1050             


Val Ile  Ile Gly Gly Ala Ser  Asn Glu Ala Gly Lys  Trp Met Asp 
    1055                 1060                 1065             


Asp Thr  Cys Asp Ser Lys Arg  Gly Tyr Ile Cys Gln  Thr Arg Ser 
    1070                 1075                 1080             


Asp Pro  Ser Leu Thr Asn Pro  Pro Ala Thr Ile Gln  Thr Asp Gly 
    1085                 1090                 1095             


Phe Val  Lys Tyr Gly Lys Ser  Ser Tyr Ser Leu Met  Arg Gln Lys 
    1100                 1105                 1110             


Phe Gln  Trp His Glu Ala Glu  Thr Tyr Cys Lys Leu  His Asn Ser 
    1115                 1120                 1125             


Leu Ile  Ala Ser Ile Leu Asp  Pro Tyr Ser Asn Ala  Phe Ala Trp 
    1130                 1135                 1140             


Leu Gln  Met Glu Thr Ser Asn  Glu Arg Val Trp Ile  Ala Leu Asn 
    1145                 1150                 1155             


Ser Asn  Leu Thr Asp Asn Gln  Tyr Thr Trp Thr Asp  Lys Trp Arg 
    1160                 1165                 1170             


Val Arg  Tyr Thr Asn Trp Ala  Ala Asp Glu Pro Lys  Leu Lys Ser 
    1175                 1180                 1185             


Ala Cys  Val Tyr Leu Asp Leu  Asp Gly Tyr Trp Lys  Thr Ala His 
    1190                 1195                 1200             


Cys Asn  Glu Ser Phe Tyr Phe  Leu Cys Lys Arg Ser  Asp Glu Ile 
    1205                 1210                 1215             


Pro Ala  Thr Glu Pro Pro Gln  Leu Pro Gly Arg Cys  Pro Glu Ser 
    1220                 1225                 1230             


Asp His  Thr Ala Trp Ile Pro  Phe His Gly His Cys  Tyr Tyr Ile 
    1235                 1240                 1245             


Glu Ser  Ser Tyr Thr Arg Asn  Trp Gly Gln Ala Ser  Leu Glu Cys 
    1250                 1255                 1260             


Leu Arg  Met Gly Ser Ser Leu  Val Ser Ile Glu Ser  Ala Ala Glu 
    1265                 1270                 1275             


Ser Ser  Phe Leu Ser Tyr Arg  Val Glu Pro Leu Lys  Ser Lys Thr 
    1280                 1285                 1290             


Asn Phe  Trp Ile Gly Leu Phe  Arg Asn Val Glu Gly  Thr Trp Leu 
    1295                 1300                 1305             


Trp Ile  Asn Asn Ser Pro Val  Ser Phe Val Asn Trp  Asn Thr Gly 
    1310                 1315                 1320             


Asp Pro  Ser Gly Glu Arg Asn  Asp Cys Val Ala Leu  His Ala Ser 
    1325                 1330                 1335             


Ser Gly  Phe Trp Ser Asn Ile  His Cys Ser Ser Tyr  Lys Gly Tyr 
    1340                 1345                 1350             


Ile Cys  Lys Arg Pro Lys Ile  Ile Asp Ala Lys Pro  Thr His Glu 
    1355                 1360                 1365             


Leu Leu  Thr Thr Lys Ala Asp  Thr Arg Lys Met Asp  Pro Ser Lys 
    1370                 1375                 1380             


Pro Ser  Ser Asn Val Ala Gly  Val Val Ile Ile Val  Ile Leu Leu 
    1385                 1390                 1395             


Ile Leu  Thr Gly Ala Gly Leu  Ala Ala Tyr Phe Phe  Tyr Lys Lys 
    1400                 1405                 1410             


Arg Arg  Val His Leu Pro Gln  Glu Gly Ala Phe Glu  Asn Thr Leu 
    1415                 1420                 1425             


Tyr Phe  Asn Ser Gln Ser Ser  Pro Gly Thr Ser Asp  Met Lys Asp 
    1430                 1435                 1440             


Leu Val  Gly Asn Ile Glu Gln  Asn Glu His Ser Val  Ile 
    1445                 1450                 1455     


<210> 13
<211> 642
<212> DNA
<213> Homo sapiens

<400> 13
tgcatcgtta gcttctcctg ataaactaat tgcctcacat tgtcactgca aatcgacacc       60

tattaatggg tctcacctcc caactgcttc cccctctgtt cttcctgcta gcatgtgccg      120

gcaactttgt ccacggacac aagtgcgata tcaccttaca ggagatcatc aaaactttga      180

acagcctcac agagcagaag actctgtgca ccgagttgac cgtaacagac atctttgctg      240

cctccaagaa cacaactgag aaggaaacct tctgcagggc tgcgactgtg ctccggcagt      300

tctacagcca ccatgagaag gacactcgct gcctgggtgc gactgcacag cagttccaca      360

ggcacaagca gctgatccga ttcctgaaac ggctcgacag gaacctctgg ggcctggcgg      420

gcttgaattc ctgtcctgtg aaggaagcca accagagtac gttggaaaac ttcttggaaa      480

ggctaaagac gatcatgaga gagaaatatt caaagtgttc gagctgaata ttttaattta      540

tgagtttttg atagctttat tttttaagta tttatatatt tataactcat cataaaataa      600

agtatatata gaatctaaaa aaaaaaaaaa aaaaaaaaaa aa                         642


<210> 14
<211> 153
<212> PRT
<213> Homo sapiens

<400> 14
Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                  55                  60                  


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                  70                  75                  80  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                  90                  95      


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
            100                 105                 110         


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                 120                 125             


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                 135                 140                 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
145                 150             


<210> 15
<211> 1629
<212> DNA
<213> Homo sapiens

<400> 15
acacatcagg ggcttgctct tgcaaaacca aaccacaaga cagacttgca aaagaaggca       60

tgcacagctc agcactgctc tgttgcctgg tcctcctgac tggggtgagg gccagcccag      120

gccagggcac ccagtctgag aacagctgca cccacttccc aggcaacctg cctaacatgc      180

ttcgagatct ccgagatgcc ttcagcagag tgaagacttt ctttcaaatg aaggatcagc      240

tggacaactt gttgttaaag gagtccttgc tggaggactt taagggttac ctgggttgcc      300

aagccttgtc tgagatgatc cagttttacc tggaggaggt gatgccccaa gctgagaacc      360

aagacccaga catcaaggcg catgtgaact ccctggggga gaacctgaag accctcaggc      420

tgaggctacg gcgctgtcat cgatttcttc cctgtgaaaa caagagcaag gccgtggagc      480

aggtgaagaa tgcctttaat aagctccaag agaaaggcat ctacaaagcc atgagtgagt      540

ttgacatctt catcaactac atagaagcct acatgacaat gaagatacga aactgagaca      600

tcagggtggc gactctatag actctaggac ataaattaga ggtctccaaa atcggatctg      660

gggctctggg atagctgacc cagccccttg agaaacctta ttgtacctct cttatagaat      720

atttattacc tctgatacct caacccccat ttctatttat ttactgagct tctctgtgaa      780

cgatttagaa agaagcccaa tattataatt tttttcaata tttattattt tcacctgttt      840

ttaagctgtt tccatagggt gacacactat ggtatttgag tgttttaaga taaattataa      900

gttacataag ggaggaaaaa aaatgttctt tggggagcca acagaagctt ccattccaag      960

cctgaccacg ctttctagct gttgagctgt tttccctgac ctccctctaa tttatcttgt     1020

ctctgggctt ggggcttcct aactgctaca aatactctta ggaagagaaa ccagggagcc     1080

cctttgatga ttaattcacc ttccagtgtc tcggagggat tcccctaacc tcattcccca     1140

accacttcat tcttgaaagc tgtggccagc ttgttattta taacaaccta aatttggttc     1200

taggccgggc gcggtggctc acgcctgtaa tcccagcact ttgggaggct gaggcgggtg     1260

gatcacttga ggtcaggagt tcctaaccag cctggtcaac atggtgaaac cccgtctcta     1320

ctaaaaatac aaaaattagc cgggcatggt ggcgcgcacc tgtaatccca gctacttggg     1380

aggctgaggc aagagaattg cttgaaccca ggagatggaa gttgcagtga gctgatatca     1440

tgcccctgta ctccagcctg ggtgacagag caagactctg tctcaaaaaa taaaaataaa     1500

aataaatttg gttctaatag aactcagttt taactagaat ttattcaatt cctctgggaa     1560

tgttacattg tttgtctgtc ttcatagcag attttaattt tgaataaata aatgtatctt     1620

attcacatc                                                             1629


<210> 16
<211> 178
<212> PRT
<213> Homo sapiens

<400> 16
Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210> 17
<211> 1282
<212> DNA
<213> Homo sapiens

<400> 17
aagccaccca gcctatgcat ccgctcctca atcctctcct gttggcactg ggcctcatgg       60

cgcttttgtt gaccacggtc attgctctca cttgccttgg cggctttgcc tccccaggcc      120

ctgtgcctcc ctctacagcc ctcagggagc tcattgagga gctggtcaac atcacccaga      180

accagaaggc tccgctctgc aatggcagca tggtatggag catcaacctg acagctggca      240

tgtactgtgc agccctggaa tccctgatca acgtgtcagg ctgcagtgcc atcgagaaga      300

cccagaggat gctgagcgga ttctgcccgc acaaggtctc agctgggcag ttttccagct      360

tgcatgtccg agacaccaaa atcgaggtgg cccagtttgt aaaggacctg ctcttacatt      420

taaagaaact ttttcgcgag ggacagttca actgaaactt cgaaagcatc attatttgca      480

gagacaggac ctgactattg aagttgcaga ttcatttttc tttctgatgt caaaaatgtc      540

ttgggtaggc gggaaggagg gttagggagg ggtaaaattc cttagcttag acctcagcct      600

gtgctgcccg tcttcagcct agccgacctc agccttcccc ttgcccaggg ctcagcctgg      660

tgggcctcct ctgtccaggg ccctgagctc ggtggaccca gggatgacat gtccctacac      720

ccctcccctg ccctagagca cactgtagca ttacagtggg tgcccccctt gccagacatg      780

tggtgggaca gggacccact tcacacacag gcaactgagg cagacagcag ctcaggcaca      840

cttcttcttg gtcttattta ttattgtgtg ttatttaaat gagtgtgttt gtcaccgttg      900

gggattgggg aagactgtgg ctgctagcac ttggagccaa gggttcagag actcagggcc      960

ccagcactaa agcagtggac accaggagtc cctggtaata agtactgtgt acagaattct     1020

gctacctcac tggggtcctg gggcctcgga gcctcatccg aggcagggtc aggagagggg     1080

cagaacagcc gctcctgtct gccagccagc agccagctct cagccaacga gtaatttatt     1140

gtttttcctt gtatttaaat attaaatatg ttagcaaaga gttaatatat agaagggtac     1200

cttgaacact gggggagggg acattgaaca agttgtttca ttgactatca aactgaagcc     1260

agaaataaag ttggtgacag at                                              1282


<210> 18
<211> 146
<212> PRT
<213> Homo sapiens

<400> 18
Met His Pro Leu Leu Asn Pro Leu Leu Leu Ala Leu Gly Leu Met Ala 
1               5                   10                  15      


Leu Leu Leu Thr Thr Val Ile Ala Leu Thr Cys Leu Gly Gly Phe Ala 
            20                  25                  30          


Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu 
        35                  40                  45              


Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly 
    50                  55                  60                  


Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala 
65                  70                  75                  80  


Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr 
                85                  90                  95      


Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln 
            100                 105                 110         


Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe 
        115                 120                 125             


Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Gln 
    130                 135                 140                 


Phe Asn 
145     


<210> 19
<211> 1686
<212> DNA
<213> Homo sapiens

<400> 19
cagacgctcc ctcagcaagg acagcagagg accagctaag agggagagaa gcaactacag       60

accccccctg aaaacaaccc tcagacgcca catcccctga caagctgcca ggcaggttct      120

cttcctctca catactgacc cacggctcca ccctctctcc cctggaaagg acaccatgag      180

cactgaaagc atgatccggg acgtggagct ggccgaggag gcgctcccca agaagacagg      240

ggggccccag ggctccaggc ggtgcttgtt cctcagcctc ttctccttcc tgatcgtggc      300

aggcgccacc acgctcttct gcctgctgca ctttggagtg atcggccccc agagggaaga      360

gttccccagg gacctctctc taatcagccc tctggcccag gcagtcagat catcttctcg      420

aaccccgagt gacaagcctg tagcccatgt tgtagcaaac cctcaagctg aggggcagct      480

ccagtggctg aaccgccggg ccaatgccct cctggccaat ggcgtggagc tgagagataa      540

ccagctggtg gtgccatcag agggcctgta cctcatctac tcccaggtcc tcttcaaggg      600

ccaaggctgc ccctccaccc atgtgctcct cacccacacc atcagccgca tcgccgtctc      660

ctaccagacc aaggtcaacc tcctctctgc catcaagagc ccctgccaga gggagacccc      720

agagggggct gaggccaagc cctggtatga gcccatctat ctgggagggg tcttccagct      780

ggagaagggt gaccgactca gcgctgagat caatcggccc gactatctcg actttgccga      840

gtctgggcag gtctactttg ggatcattgc cctgtgagga ggacgaacat ccaaccttcc      900

caaacgcctc ccctgcccca atccctttat taccccctcc ttcagacacc ctcaacctct      960

tctggctcaa aaagagaatt gggggcttag ggtcggaacc caagcttaga actttaagca     1020

acaagaccac cacttcgaaa cctgggattc aggaatgtgt ggcctgcaca gtgaagtgct     1080

ggcaaccact aagaattcaa actggggcct ccagaactca ctggggccta cagctttgat     1140

ccctgacatc tggaatctgg agaccaggga gcctttggtt ctggccagaa tgctgcagga     1200

cttgagaaga cctcacctag aaattgacac aagtggacct taggccttcc tctctccaga     1260

tgtttccaga cttccttgag acacggagcc cagccctccc catggagcca gctccctcta     1320

tttatgtttg cacttgtgat tatttattat ttatttatta tttatttatt tacagatgaa     1380

tgtatttatt tgggagaccg gggtatcctg ggggacccaa tgtaggagct gccttggctc     1440

agacatgttt tccgtgaaaa cggagctgaa caataggctg ttcccatgta gccccctggc     1500

ctctgtgcct tcttttgatt atgtttttta aaatatttat ctgattaagt tgtctaaaca     1560

atgctgattt ggtgaccaac tgtcactcat tgctgagcct ctgctcccca ggggagttgt     1620

gtctgtaatc gccctactat tcagtggcga gaaataaagt ttgcttagaa aagaaaaaaa     1680

aaaaaa                                                                1686


<210> 20
<211> 233
<212> PRT
<213> Homo sapiens

<400> 20
Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210> 21
<211> 1049
<212> DNA
<213> Homo sapiens

<400> 21
aaaacaacag gaagcagctt acaaactcgg tgaacaactg agggaaccaa accagagacg       60

cgctgaacag agagaatcag gctcaaagca agtggaagtg ggcagagatt ccaccaggac      120

tggtgcaagg cgcagagcca gccagatttg agaagaaggc aaaaagatgc tggggagcag      180

agctgtaatg ctgctgttgc tgctgccctg gacagctcag ggcagagctg tgcctggggg      240

cagcagccct gcctggactc agtgccagca gctttcacag aagctctgca cactggcctg      300

gagtgcacat ccactagtgg gacacatgga tctaagagaa gagggagatg aagagactac      360

aaatgatgtt ccccatatcc agtgtggaga tggctgtgac ccccaaggac tcagggacaa      420

cagtcagttc tgcttgcaaa ggatccacca gggtctgatt ttttatgaga agctgctagg      480

atcggatatt ttcacagggg agccttctct gctccctgat agccctgtgg gccagcttca      540

tgcctcccta ctgggcctca gccaactcct gcagcctgag ggtcaccact gggagactca      600

gcagattcca agcctcagtc ccagccagcc atggcagcgt ctccttctcc gcttcaaaat      660

ccttcgcagc ctccaggcct ttgtggctgt agccgcccgg gtctttgccc atggagcagc      720

aaccctgagt ccctaaaggc agcagctcaa ggatggcact cagatctcca tggcccagca      780

aggccaagat aaatctacca ccccaggcac ctgtgagcca acaggttaat tagtccatta      840

attttagtgg gacctgcata tgttgaaaat taccaatact gactgacatg tgatgctgac      900

ctatgataag gttgagtatt tattagatgg gaagggaaat ttggggatta tttatcctcc      960

tggggacagt ttggggagga ttatttattg tatttatatt gaattatgta cttttttcaa     1020

taaagtctta tttttgtggc taaaaaaaa                                       1049


<210> 22
<211> 189
<212> PRT
<213> Homo sapiens

<400> 22
Met Leu Gly Ser Arg Ala Val Met Leu Leu Leu Leu Leu Pro Trp Thr 
1               5                   10                  15      


Ala Gln Gly Arg Ala Val Pro Gly Gly Ser Ser Pro Ala Trp Thr Gln 
            20                  25                  30          


Cys Gln Gln Leu Ser Gln Lys Leu Cys Thr Leu Ala Trp Ser Ala His 
        35                  40                  45              


Pro Leu Val Gly His Met Asp Leu Arg Glu Glu Gly Asp Glu Glu Thr 
    50                  55                  60                  


Thr Asn Asp Val Pro His Ile Gln Cys Gly Asp Gly Cys Asp Pro Gln 
65                  70                  75                  80  


Gly Leu Arg Asp Asn Ser Gln Phe Cys Leu Gln Arg Ile His Gln Gly 
                85                  90                  95      


Leu Ile Phe Tyr Glu Lys Leu Leu Gly Ser Asp Ile Phe Thr Gly Glu 
            100                 105                 110         


Pro Ser Leu Leu Pro Asp Ser Pro Val Gly Gln Leu His Ala Ser Leu 
        115                 120                 125             


Leu Gly Leu Ser Gln Leu Leu Gln Pro Glu Gly His His Trp Glu Thr 
    130                 135                 140                 


Gln Gln Ile Pro Ser Leu Ser Pro Ser Gln Pro Trp Gln Arg Leu Leu 
145                 150                 155                 160 


Leu Arg Phe Lys Ile Leu Arg Ser Leu Gln Ala Phe Val Ala Val Ala 
                165                 170                 175     


Ala Arg Val Phe Ala His Gly Ala Ala Thr Leu Ser Pro 
            180                 185                 


<210> 23
<211> 2347
<212> DNA
<213> Homo sapiens

<400> 23
ctgtttcagg gccattggac tctccgtcct gcccagagca agatgtgtca ccagcagttg       60

gtcatctctt ggttttccct ggtttttctg gcatctcccc tcgtggccat atgggaactg      120

aagaaagatg tttatgtcgt agaattggat tggtatccgg atgcccctgg agaaatggtg      180

gtcctcacct gtgacacccc tgaagaagat ggtatcacct ggaccttgga ccagagcagt      240

gaggtcttag gctctggcaa aaccctgacc atccaagtca aagagtttgg agatgctggc      300

cagtacacct gtcacaaagg aggcgaggtt ctaagccatt cgctcctgct gcttcacaaa      360

aaggaagatg gaatttggtc cactgatatt ttaaaggacc agaaagaacc caaaaataag      420

acctttctaa gatgcgaggc caagaattat tctggacgtt tcacctgctg gtggctgacg      480

acaatcagta ctgatttgac attcagtgtc aaaagcagca gaggctcttc tgacccccaa      540

ggggtgacgt gcggagctgc tacactctct gcagagagag tcagagggga caacaaggag      600

tatgagtact cagtggagtg ccaggaggac agtgcctgcc cagctgctga ggagagtctg      660

cccattgagg tcatggtgga tgccgttcac aagctcaagt atgaaaacta caccagcagc      720

ttcttcatca gggacatcat caaacctgac ccacccaaga acttgcagct gaagccatta      780

aagaattctc ggcaggtgga ggtcagctgg gagtaccctg acacctggag tactccacat      840

tcctacttct ccctgacatt ctgcgttcag gtccagggca agagcaagag agaaaagaaa      900

gatagagtct tcacggacaa gacctcagcc acggtcatct gccgcaaaaa tgccagcatt      960

agcgtgcggg cccaggaccg ctactatagc tcatcttgga gcgaatgggc atctgtgccc     1020

tgcagttagg ttctgatcca ggatgaaaat ttggaggaaa agtggaagat attaagcaaa     1080

atgtttaaag acacaacgga atagacccaa aaagataatt tctatctgat ttgctttaaa     1140

acgttttttt aggatcacaa tgatatcttt gctgtatttg tatagttaga tgctaaatgc     1200

tcattgaaac aatcagctaa tttatgtata gattttccag ctctcaagtt gccatgggcc     1260

ttcatgctat ttaaatattt aagtaattta tgtatttatt agtatattac tgttatttaa     1320

cgtttgtctg ccaggatgta tggaatgttt catactctta tgacctgatc catcaggatc     1380

agtccctatt atgcaaaatg tgaatttaat tttatttgta ctgacaactt ttcaagcaag     1440

gctgcaagta catcagtttt atgacaatca ggaagaatgc agtgttctga taccagtgcc     1500

atcatacact tgtgatggat gggaacgcaa gagatactta catggaaacc tgacaatgca     1560

aacctgttga gaagatccag gagaacaaga tgctagttcc catgtctgtg aagacttcct     1620

ggagatggtg ttgataaagc aatttagggc cacttacact tctaagcaag tttaatcttt     1680

ggatgcctga attttaaaag ggctagaaaa aaatgattga ccagcctggg aaacataaca     1740

agaccccgtc tctacaaaaa aaatttaaaa ttagccaggc gtggtggctc atgcttgtgg     1800

tcccagctgt tcaggaggat gaggcaggag gatctcttga gcccaggagg tcaaggctat     1860

ggtgagccgt gattgtgcca ctgcatacca gcctaggtga cagaatgaga ccctgtctca     1920

aaaaaaaaaa tgattgaaat taaaattcag ctttagcttc catggcagtc ctcaccccca     1980

cctctctaaa agacacagga ggatgacaca gaaacaccgt aagtgtctgg aaggcaaaaa     2040

gatcttaaga ttcaagagag aggacaagta gttatggcta aggacatgaa attgtcagaa     2100

tggcaggtgg cttcttaaca gccctgtgag aagcagacag atgcaaagaa aatctggaat     2160

ccctttctca ttagcatgaa tgaacctgat acacaattat gaccagaaaa tatggctcca     2220

tgaaggtgct acttttaagt aatgtatgtg cgctctgtaa agtgattaca tttgtttcct     2280

gtttgtttat ttatttattt atttttgcat tctgaggctg aactaataaa aactcttctt     2340

tgtaatc                                                               2347


<210> 24
<211> 328
<212> PRT
<213> Homo sapiens

<400> 24
Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210> 25
<211> 1498
<212> DNA
<213> Homo sapiens

<400> 25
accaaacctc ttcgaggcac aaggcacaac aggctgctct gggattctct tcagccaatc       60

ttcattgctc aagtgtctga agcagccatg gcagaagtac ctgagctcgc cagtgaaatg      120

atggcttatt acagtggcaa tgaggatgac ttgttctttg aagctgatgg ccctaaacag      180

atgaagtgct ccttccagga cctggacctc tgccctctgg atggcggcat ccagctacga      240

atctccgacc accactacag caagggcttc aggcaggccg cgtcagttgt tgtggccatg      300

gacaagctga ggaagatgct ggttccctgc ccacagacct tccaggagaa tgacctgagc      360

accttctttc ccttcatctt tgaagaagaa cctatcttct tcgacacatg ggataacgag      420

gcttatgtgc acgatgcacc tgtacgatca ctgaactgca cgctccggga ctcacagcaa      480

aaaagcttgg tgatgtctgg tccatatgaa ctgaaagctc tccacctcca gggacaggat      540

atggagcaac aagtggtgtt ctccatgtcc tttgtacaag gagaagaaag taatgacaaa      600

atacctgtgg ccttgggcct caaggaaaag aatctgtacc tgtcctgcgt gttgaaagat      660

gataagccca ctctacagct ggagagtgta gatcccaaaa attacccaaa gaagaagatg      720

gaaaagcgat ttgtcttcaa caagatagaa atcaataaca agctggaatt tgagtctgcc      780

cagttcccca actggtacat cagcacctct caagcagaaa acatgcccgt cttcctggga      840

gggaccaaag gcggccagga tataactgac ttcaccatgc aatttgtgtc ttcctaaaga      900

gagctgtacc cagagagtcc tgtgctgaat gtggactcaa tccctagggc tggcagaaag      960

ggaacagaaa ggtttttgag tacggctata gcctggactt tcctgttgtc tacaccaatg     1020

cccaactgcc tgccttaggg tagtgctaag aggatctcct gtccatcagc caggacagtc     1080

agctctctcc tttcagggcc aatccccagc ccttttgttg agccaggcct ctctcacctc     1140

tcctactcac ttaaagcccg cctgacagaa accacggcca catttggttc taagaaaccc     1200

tctgtcattc gctcccacat tctgatgagc aaccgcttcc ctatttattt atttatttgt     1260

ttgtttgttt tattcattgg tctaatttat tcaaaggggg caagaagtag cagtgtctgt     1320

aaaagagcct agtttttaat agctatggaa tcaattcaat ttggactggt gtgctctctt     1380

taaatcaagt cctttaatta agactgaaaa tatataagct cagattattt aaatgggaat     1440

atttataaat gagcaaatat catactgttc aatggttctg aaataaactt cactgaag       1498


<210> 26
<211> 269
<212> PRT
<213> Homo sapiens

<400> 26
Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         


Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 


Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     


Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 


<210> 27
<211> 813
<212> DNA
<213> Homo sapiens

<400> 27
agctggtttc agacttcaga aggacacggg cagcagacag tggtcagtcc tttcttggct       60

ctgctgacac tcgagcccac attccgtcac ctgctcagaa tcatgcaggt ctccactgct      120

gcccttgctg tcctcctctg caccatggct ctctgcaacc agttctctgc atcacttgct      180

gctgacacgc cgaccgcctg ctgcttcagc tacacctccc ggcagattcc acagaatttc      240

atagctgact actttgagac gagcagccag tgctccaagc ccggtgtcat cttcctaacc      300

aagcgaagcc ggcaggtctg tgctgacccc agtgaggagt gggtccagaa atatgtcagc      360

gacctggagc tgagtgcctg aggggtccag aagcttcgag gcccagcgac ctcggtgggc      420

ccagtgggga ggagcaggag cctgagcctt gggaacatgc gtgtgacctc cacagctacc      480

tcttctatgg actggttgtt gccaaacagc cacactgtgg gactcttctt aacttaaatt      540

ttaatttatt tatactattt agtttttgta atttattttc gatttcacag tgtgtttgtg      600

attgtttgct ctgagagttc ccctgtcccc tcccccttcc ctcacaccgc gtctggtgac      660

aaccgagtgg ctgtcatcag cctgtgtagg cagtcatggc accaaagcca ccagactgac      720

aaatgtgtat cggatgcttt tgttcagggc tgtgatcggc ctggggaaat aataaagatg      780

ctcttttaaa aggtaaaaaa aaaaaaaaaa aaa                                   813


<210> 28
<211> 92
<212> PRT
<213> Homo sapiens

<400> 28
Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Phe Ser Ala Ser Leu Ala Ala Asp Thr Pro Thr Ala 
            20                  25                  30          


Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile Ala 
        35                  40                  45              


Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Gly Val Ile Phe 
    50                  55                  60                  


Leu Thr Lys Arg Ser Arg Gln Val Cys Ala Asp Pro Ser Glu Glu Trp 
65                  70                  75                  80  


Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala 
                85                  90          


<210> 29
<211> 1319
<212> DNA
<213> Homo sapiens

<400> 29
gctgcagagg attcctgcag aggatcaaga cagcacgtgg acctcgcaca gcctctccca       60

caggtaccat gaaggtctcc gcggcagccc tcgctgtcat cctcattgct actgccctct      120

gcgctcctgc atctgcctcc ccatattcct cggacaccac accctgctgc tttgcctaca      180

ttgcccgccc actgccccgt gcccacatca aggagtattt ctacaccagt ggcaagtgct      240

ccaacccagc agtcgtccac aggtcaagga tgccaaagag agagggacag caagtctggc      300

aggatttcct gtatgactcc cggctgaaca agggcaagct ttgtcacccg aaagaaccgc      360

caagtgtgtg ccaacccaga gaagaaatgg gttcgggagt acatcaactc tttggagatg      420

agctaggatg gagagtcctt gaacctgaac ttacacaaat ttgcctgttt ctgcttgctc      480

ttgtcctagc ttgggaggct tcccctcact atcctacccc acccgctcct tgaagggccc      540

agattctacc acacagcagc agttacaaaa accttcccca ggctggacgt ggtggctcac      600

gcctgtaatc ccagcacttt gggaggccaa ggtgggtgga tcacttgagg tcaggagttc      660

gagaccagcc tggccaacat gatgaaaccc catctctact aaaaatacaa aaaattagcc      720

gggcgtggta gcgggcgcct gtagtcccag ctactcggga ggctgaggca ggagaatggc      780

gtgaacccgg gaggcggagc ttgcagtgag ccgagatcgc gccactgcac tccagcctgg      840

gcgacagagc gagactccgt ctcaaaaaaa aaaaaaaaaa aaaaaataca aaaattagcc      900

gggcgtggtg gcccacgcct gtaatcccag ctactcggga ggctaaggca ggaaaattgt      960

ttgaacccag gaggtggagg ctgcagtgag ctgagattgt gccacttcac tccagcctgg     1020

gtgacaaagt gagactccgt cacaacaaca acaacaaaaa gcttccccaa ctaaagccta     1080

gaagagcttc tgaggcgctg ctttgtcaaa aggaagtctc taggttctga gctctggctt     1140

tgccttggct ttgccagggc tctgtgacca ggaaggaagt cagcatgcct ctagaggcaa     1200

ggaggggagg aacactgcac tcttaagctt ccgccgtctc aacccctcac aggagcttac     1260

tggcaaacat gaaaaatcgg cttaccatta aagttctcaa tgcaaccata aaaaaaaaa      1319


<210> 30
<211> 154
<212> PRT
<213> Homo sapiens

<400> 30
Met Lys Val Ser Ala Ala Ala Leu Ala Val Ile Leu Ile Ala Thr Ala 
1               5                   10                  15      


Leu Cys Ala Pro Ala Ser Ala Ser Pro Tyr Ser Ser Asp Thr Thr Pro 
            20                  25                  30          


Cys Cys Phe Ala Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys 
        35                  40                  45              


Glu Tyr Phe Tyr Thr Ser Gly Lys Cys Ser Asn Pro Ala Val Val His 
    50                  55                  60                  


Arg Ser Arg Met Pro Lys Arg Glu Gly Gln Gln Val Trp Gln Asp Phe 
65                  70                  75                  80  


Leu Tyr Asp Ser Arg Leu Asn Lys Gly Lys Leu Cys His Pro Lys Glu 
                85                  90                  95      


Pro Pro Ser Val Cys Gln Pro Arg Glu Glu Met Gly Ser Gly Val His 
            100                 105                 110         


Gln Leu Phe Gly Asp Glu Leu Gly Trp Arg Val Leu Glu Pro Glu Leu 
        115                 120                 125             


Thr Gln Ile Cys Leu Phe Leu Leu Ala Leu Val Leu Ala Trp Glu Ala 
    130                 135                 140                 


Ser Pro His Tyr Pro Thr Pro Pro Ala Pro 
145                 150                 


<210> 31
<211> 2757
<212> DNA
<213> Homo sapiens

<400> 31
gacaagtact gagtgaactc aaaccctctg taaagtaaca gaagttagaa ggggaaatgt       60

cgcctctctg aagattaccc aaagaaaaag tgatttgtca ttgctttata gactgtaaga      120

agagaacatc tcagaagtgg agtcttaccc tgaaatcaaa ggatttaaag aaaaagtgga      180

atttttcttc agcaagctgt gaaactaaat ccacaacctt tggagaccca ggaacaccct      240

ccaatctctg tgtgttttgt aaacatcact ggagggtctt ctacgtgagc aattggattg      300

tcatcagccc tgcctgtttt gcacctggga agtgccctgg tcttacttgg gtccaaattg      360

ttggctttca cttttgaccc taagcatctg aagccatggg ccacacacgg aggcagggaa      420

catcaccatc caagtgtcca tacctcaatt tctttcagct cttggtgctg gctggtcttt      480

ctcacttctg ttcaggtgtt atccacgtga ccaaggaagt gaaagaagtg gcaacgctgt      540

cctgtggtca caatgtttct gttgaagagc tggcacaaac tcgcatctac tggcaaaagg      600

agaagaaaat ggtgctgact atgatgtctg gggacatgaa tatatggccc gagtacaaga      660

accggaccat ctttgatatc actaataacc tctccattgt gatcctggct ctgcgcccat      720

ctgacgaggg cacatacgag tgtgttgttc tgaagtatga aaaagacgct ttcaagcggg      780

aacacctggc tgaagtgacg ttatcagtca aagctgactt ccctacacct agtatatctg      840

actttgaaat tccaacttct aatattagaa ggataatttg ctcaacctct ggaggttttc      900

cagagcctca cctctcctgg ttggaaaatg gagaagaatt aaatgccatc aacacaacag      960

tttcccaaga tcctgaaact gagctctatg ctgttagcag caaactggat ttcaatatga     1020

caaccaacca cagcttcatg tgtctcatca agtatggaca tttaagagtg aatcagacct     1080

tcaactggaa tacaaccaag caagagcatt ttcctgataa cctgctccca tcctgggcca     1140

ttaccttaat ctcagtaaat ggaatttttg tgatatgctg cctgacctac tgctttgccc     1200

caagatgcag agagagaagg aggaatgaga gattgagaag ggaaagtgta cgccctgtat     1260

aacagtgtcc gcagaagcaa ggggctgaaa agatctgaag gtcccacctc catttgcaat     1320

tgacctcttc tgggaacttc ctcagatgga caagattacc ccaccttgcc ctttacgtat     1380

ctgctcttag gtgcttcttc acttcagttg ctttgcagga agtgtctaga ggaatatggt     1440

gggcacagaa gtagctctgg tgaccttgat caaggtgttt tgaaatgcag aattcttgag     1500

ttctggaagg gactttagag aataccagtg ttattaatga caaaggcact gaggcccagg     1560

gaggtgaccc gaattataaa ggccagcgcc agaacccaga tttcctaact ctggtgctct     1620

ttccctttat cagtttgact gtggcctgtt aactggtata tacatatata tgtcaggcaa     1680

agtgctgctg gaagtagaat ttgtccaata acaggtcaac ttcagagact atctgatttc     1740

ctaatgtcag agtagaagat tttatgctgc tgtttacaaa agcccaatgt aatgcatagg     1800

aagtatggca tgaacatctt taggagacta atggaaatat tattggtgtt tacccagtat     1860

tccatttttt tcattgtgtt ctctattgct gctctctcac tcccccatga ggtacagcag     1920

aaaggagaac tatccaaaac taatttcctc tgacatgtaa gacgaatgat ttaggtacgt     1980

caaagcagta gtcaaggagg aaagggatag tccaaagact taactggttc atattggact     2040

gataatctct ttaaatggct ttatgctagt ttgacctcat ttgtaaaata tttatgagaa     2100

agttctcatt taaaatgaga tcgttgttta cagtgtatgt actaagcagt aagctatctt     2160

caaatgtcta aggtagtaac tttccatagg gcctccttag atccctaaga tggctttttc     2220

tccttggtat ttctgggtct ttctgacatc agcagagaac tggaaagaca tagccaactg     2280

ctgttcatgt tactcatgac tcctttctct aaaactgcct tccacaattc actagaccag     2340

aagtggacgc aacttaagct gggataatca cattatcatc tgaaaatctg gagttgaaca     2400

gcaaaagaag acaacatttc tcaaatgcac atctcatggc agctaagcca catggctggg     2460

atttaaagcc tttagagcca gcccatggct ttagctacct cactatgctg cttcacaaac     2520

cttgctcctg tgtaaaacta tattctcagt gtagggcaga gaggtctaac accaacataa     2580

ggtactagca gtgtttcccg tattgacagg aatacttaac tcaataattc ttttcttttc     2640

catttagtaa cagttgtgat gactatgttt ctattctaag taattcctgt attctacagc     2700

agatactttg tcagcaatac taagggaaga aacaaagttg aaccgtttct ttaataa        2757


<210> 32
<211> 288
<212> PRT
<213> Homo sapiens

<400> 32
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg 
            260                 265                 270         


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
        275                 280                 285             


<210> 33
<211> 2207
<212> DNA
<213> Homo sapiens

<400> 33
cacttcctcc ccagacaggg gtagtgcgag gccgggcaca gccttcctgt gtggttttac       60

cgcccagaga gcgtcatgga cctggggaaa ccaatgaaaa gcgtgctggt ggtggctctc      120

cttgtcattt tccaggtatg cctgtgtcaa gatgaggtca cggacgatta catcggagac      180

aacaccacag tggactacac tttgttcgag tctttgtgct ccaagaagga cgtgcggaac      240

tttaaagcct ggttcctccc tatcatgtac tccatcattt gtttcgtggg cctactgggc      300

aatgggctgg tcgtgttgac ctatatctat ttcaagaggc tcaagaccat gaccgatacc      360

tacctgctca acctggcggt ggcagacatc ctcttcctcc tgacccttcc cttctgggcc      420

tacagcgcgg ccaagtcctg ggtcttcggt gtccactttt gcaagctcat ctttgccatc      480

tacaagatga gcttcttcag tggcatgctc ctacttcttt gcatcagcat tgaccgctac      540

gtggccatcg tccaggctgt ctcagctcac cgccaccgtg cccgcgtcct tctcatcagc      600

aagctgtcct gtgtgggcat ctggatacta gccacagtgc tctccatccc agagctcctg      660

tacagtgacc tccagaggag cagcagtgag caagcgatgc gatgctctct catcacagag      720

catgtggagg cctttatcac catccaggtg gcccagatgg tgatcggctt tctggtcccc      780

ctgctggcca tgagcttctg ttaccttgtc atcatccgca ccctgctcca ggcacgcaac      840

tttgagcgca acaaggccat caaggtgatc atcgctgtgg tcgtggtctt catagtcttc      900

cagctgccct acaatggggt ggtcctggcc cagacggtgg ccaacttcaa catcaccagt      960

agcacctgtg agctcagtaa gcaactcaac atcgcctacg acgtcaccta cagcctggcc     1020

tgcgtccgct gctgcgtcaa ccctttcttg tacgccttca tcggcgtcaa gttccgcaac     1080

gatctcttca agctcttcaa ggacctgggc tgcctcagcc aggagcagct ccggcagtgg     1140

tcttcctgtc ggcacatccg gcgctcctcc atgagtgtgg aggccgagac caccaccacc     1200

ttctccccat aggcgactct tctgcctgga ctagagggac ctctcccagg gtccctgggg     1260

tggggatagg gagcagatgc aatgactcag gacatccccc cgccaaaagc tgctcaggga     1320

aaagcagctc tcccctcaga gtgcaagccc ctgctccaga agatagcttc accccaatcc     1380

cagctacctc aaccaatgcc aaaaaaagac agggctgata agctaacacc agacagacaa     1440

cactgggaaa cagaggctat tgtcccctaa accaaaaact gaaagtgaaa gtccagaaac     1500

tgttcccacc tgctggagtg aaggggccaa ggagggtgag tgcaaggggc gtgggagtgg     1560

cctgaagagt cctctgaatg aaccttctgg cctcccacag actcaaatgc tcagaccagc     1620

tcttccgaaa accaggcctt atctccaaga ccagagatag tggggagact tcttggcttg     1680

gtgaggaaaa gcggacatca gctggtcaaa caaactctct gaacccctcc ctccatcgtt     1740

ttcttcactg tcctccaagc cagcgggaat ggcagctgcc acgccgccct aaaagcacac     1800

tcatcccctc acttgccgcg tcgccctccc aggctctcaa caggggagag tgtggtgttt     1860

cctgcaggcc aggccagctg cctccgcgtg atcaaagcca cactctgggc tccagagtgg     1920

ggatgacatg cactcagctc ttggctccac tgggatggga ggagaggaca agggaaatgt     1980

caggggcggg gagggtgaca gtggccgccc aaggcccacg agcttgttct ttgttctttg     2040

tcacagggac tgaaaacctc tcctcatgtt ctgctttcga ttcgttaaga gagcaacatt     2100

ttacccacac acagataaag ttttcccttg aggaaacaac agctttaaaa gaaaaagaaa     2160

aaaaaagtct ttggtaaatg gcaaaaaaaa aaaaaaaaaa aaaaaaa                   2207


<210> 34
<211> 378
<212> PRT
<213> Homo sapiens

<400> 34
Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210> 35
<211> 4206
<212> DNA
<213> Homo sapiens

<400> 35
ataactttgt agcgagtcga aaactgaggc tccggccgca gagaactcag cctcattcct       60

gctttaaaat ctctcggcca cctttgatga ggggactggg cagttctaga cagtcccgaa      120

gttctcaagg cacaggtctc ttcctggttt gactgtcctt accccgggga ggcagtgcag      180

ccagctgcaa gccccacagt gaagaacatc tgagctcaaa tccagataag tgacataagt      240

gacctgcttt gtaaagccat agagatggcc tgtccttgga aatttctgtt caagaccaaa      300

ttccaccagt atgcaatgaa tggggaaaaa gacatcaaca acaatgtgga gaaagccccc      360

tgtgccacct ccagtccagt gacacaggat gaccttcagt atcacaacct cagcaagcag      420

cagaatgagt ccccgcagcc cctcgtggag acgggaaaga agtctccaga atctctggtc      480

aagctggatg caaccccatt gtcctcccca cggcatgtga ggatcaaaaa ctggggcagc      540

gggatgactt tccaagacac acttcaccat aaggccaaag ggattttaac ttgcaggtcc      600

aaatcttgcc tggggtccat tatgactccc aaaagtttga ccagaggacc cagggacaag      660

cctacccctc cagatgagct tctacctcaa gctatcgaat ttgtcaacca atattacggc      720

tccttcaaag aggcaaaaat agaggaacat ctggccaggg tggaagcggt aacaaaggag      780

atagaaacaa caggaaccta ccaactgacg ggagatgagc tcatcttcgc caccaagcag      840

gcctggcgca atgccccacg ctgcattggg aggatccagt ggtccaacct gcaggtcttc      900

gatgcccgca gctgttccac tgcccgggaa atgtttgaac acatctgcag acacgtgcgt      960

tactccacca acaatggcaa catcaggtcg gccatcaccg tgttccccca gcggagtgat     1020

ggcaagcacg acttccgggt gtggaatgct cagctcatcc gctatgctgg ctaccagatg     1080

ccagatggca gcatcagagg ggaccctgcc aacgtggaat tcactcagct gtgcatcgac     1140

ctgggctgga agcccaagta cggccgcttc gatgtggtcc ccctggtcct gcaggccaat     1200

ggccgtgacc ctgagctctt cgaaatccca cctgaccttg tgcttgaggt ggccatggaa     1260

catcccaaat acgagtggtt tcgggaactg gagctaaagt ggtacgccct gcctgcagtg     1320

gccaacatgc tgcttgaggt gggcggcctg gagttcccag ggtgcccctt caatggctgg     1380

tacatgggca cagagatcgg agtccgggac ttctgtgacg tccagcgcta caacatcctg     1440

gaggaagtgg gcaggagaat gggcctggaa acgcacaagc tggcctcgct ctggaaagac     1500

caggctgtcg ttgagatcaa cattgctgtg ctccatagtt tccagaagca gaatgtgacc     1560

atcatggacc accactcggc tgcagaatcc ttcatgaagt acatgcagaa tgaataccgg     1620

tcccgtgggg gctgcccggc agactggatt tggctggtcc ctcccatgtc tgggagcatc     1680

acccccgtgt ttcaccagga gatgctgaac tacgtcctgt cccctttcta ctactatcag     1740

gtagaggcct ggaaaaccca tgtctggcag gacgagaagc ggagacccaa gagaagagag     1800

attccattga aagtcttggt caaagctgtg ctctttgcct gtatgctgat gcgcaagaca     1860

atggcgtccc gagtcagagt caccatcctc tttgcgacag agacaggaaa atcagaggcg     1920

ctggcctggg acctgggggc cttattcagc tgtgccttca accccaaggt tgtctgcatg     1980

gataagtaca ggctgagctg cctggaggag gaacggctgc tgttggtggt gaccagtacg     2040

tttggcaatg gagactgccc tggcaatgga gagaaactga agaaatcgct cttcatgctg     2100

aaagagctca acaacaaatt caggtacgct gtgtttggcc tcggctccag catgtaccct     2160

cggttctgcg cctttgctca tgacattgat cagaagctgt cccacctggg ggcctctcag     2220

ctcaccccga tgggagaagg ggatgagctc agtgggcagg aggacgcctt ccgcagctgg     2280

gccgtgcaaa ccttcaaggc agcctgtgag acgtttgatg tccgaggcaa acagcacatt     2340

cagatcccca agctctacac ctccaatgtg acctgggacc cgcaccacta caggctcgtg     2400

caggactcac agcctttgga cctcagcaaa gccctcagca gcatgcatgc caagaacgtg     2460

ttcaccatga ggctcaaatc tcggcagaat ctacaaagtc cgacatccag ccgtgccacc     2520

atcctggtgg aactctcctg tgaggatggc caaggcctga actacctgcc gggggagcac     2580

cttggggttt gcccaggcaa ccagccggcc ctggtccaag gtatcctgga gcgagtggtg     2640

gatggcccca caccccacca gacagtgcgc ctggaggccc tggatgagag tggcagctac     2700

tgggtcagtg acaagaggct gcccccctgc tcactcagcc aggccctcac ctacttcctg     2760

gacatcacca cacccccaac ccagctgctg ctccaaaagc tggcccaggt ggccacagaa     2820

gagcctgaga gacagaggct ggaggccctg tgccagccct cagagtacag caagtggaag     2880

ttcaccaaca gccccacatt cctggaggtg ctagaggagt tcccgtccct gcgggtgtct     2940

gctggcttcc tgctttccca gctccccatt ctgaagccca ggttctactc catcagctcc     3000

tcccgggatc acacgcccac agagatccac ctgactgtgg ccgtggtcac ctaccacacc     3060

cgagatggcc agggtcccct gcaccacggc gtctgcagca catggctcaa cagcctgaag     3120

ccccaagacc cagtgccctg ctttgtgcgg aatgccagcg gcttccacct ccccgaggat     3180

ccctcccatc cttgcatcct catcgggcct ggcacaggca tcgcgccctt ccgcagtttc     3240

tggcagcaac ggctccatga ctcccagcac aagggagtgc ggggaggccg catgaccttg     3300

gtgtttgggt gccgccgccc agatgaggac cacatctacc aggaggagat gctggagatg     3360

gcccagaagg gggtgctgca tgcggtgcac acagcctatt cccgcctgcc tggcaagccc     3420

aaggtctatg ttcaggacat cctgcggcag cagctggcca gcgaggtgct ccgtgtgctc     3480

cacaaggagc caggccacct ctatgtttgc ggggatgtgc gcatggcccg ggacgtggcc     3540

cacaccctga agcagctggt ggctgccaag ctgaaattga atgaggagca ggtcgaggac     3600

tatttctttc agctcaagag ccagaagcgc tatcacgaag atatctttgg tgctgtattt     3660

ccttacgagg cgaagaagga cagggtggcg gtgcagccca gcagcctgga gatgtcagcg     3720

ctctgagggc ctacaggagg ggttaaagct gccggcacag aacttaagga tggagccagc     3780

tctgcattat ctgaggtcac agggcctggg gagatggagg aaagtgatat cccccagcct     3840

caagtcttat ttcctcaacg ttgctcccca tcaagccctt tacttgacct cctaacaagt     3900

agcaccctgg attgatcgga gcctcctctc tcaaactggg gcctccctgg tcccttggag     3960

acaaaatctt aaatgccagg cctggcaagt gggtgaaaga tggaacttgc tgctgagtgc     4020

accacttcaa gtgaccacca ggaggtgcta tcgcaccact gtgtatttaa ctgccttgtg     4080

tacagttatt tatgcctctg tatttaaaaa actaacaccc agtctgttcc ccatggccac     4140

ttgggtcttc cctgtatgat tccttgatgg agatatttac atgaattgca ttttacttta     4200

atcaca                                                                4206


<210> 36
<211> 1153
<212> PRT
<213> Homo sapiens

<400> 36
Met Ala Cys Pro Trp Lys Phe Leu Phe Lys Thr Lys Phe His Gln Tyr 
1               5                   10                  15      


Ala Met Asn Gly Glu Lys Asp Ile Asn Asn Asn Val Glu Lys Ala Pro 
            20                  25                  30          


Cys Ala Thr Ser Ser Pro Val Thr Gln Asp Asp Leu Gln Tyr His Asn 
        35                  40                  45              


Leu Ser Lys Gln Gln Asn Glu Ser Pro Gln Pro Leu Val Glu Thr Gly 
    50                  55                  60                  


Lys Lys Ser Pro Glu Ser Leu Val Lys Leu Asp Ala Thr Pro Leu Ser 
65                  70                  75                  80  


Ser Pro Arg His Val Arg Ile Lys Asn Trp Gly Ser Gly Met Thr Phe 
                85                  90                  95      


Gln Asp Thr Leu His His Lys Ala Lys Gly Ile Leu Thr Cys Arg Ser 
            100                 105                 110         


Lys Ser Cys Leu Gly Ser Ile Met Thr Pro Lys Ser Leu Thr Arg Gly 
        115                 120                 125             


Pro Arg Asp Lys Pro Thr Pro Pro Asp Glu Leu Leu Pro Gln Ala Ile 
    130                 135                 140                 


Glu Phe Val Asn Gln Tyr Tyr Gly Ser Phe Lys Glu Ala Lys Ile Glu 
145                 150                 155                 160 


Glu His Leu Ala Arg Val Glu Ala Val Thr Lys Glu Ile Glu Thr Thr 
                165                 170                 175     


Gly Thr Tyr Gln Leu Thr Gly Asp Glu Leu Ile Phe Ala Thr Lys Gln 
            180                 185                 190         


Ala Trp Arg Asn Ala Pro Arg Cys Ile Gly Arg Ile Gln Trp Ser Asn 
        195                 200                 205             


Leu Gln Val Phe Asp Ala Arg Ser Cys Ser Thr Ala Arg Glu Met Phe 
    210                 215                 220                 


Glu His Ile Cys Arg His Val Arg Tyr Ser Thr Asn Asn Gly Asn Ile 
225                 230                 235                 240 


Arg Ser Ala Ile Thr Val Phe Pro Gln Arg Ser Asp Gly Lys His Asp 
                245                 250                 255     


Phe Arg Val Trp Asn Ala Gln Leu Ile Arg Tyr Ala Gly Tyr Gln Met 
            260                 265                 270         


Pro Asp Gly Ser Ile Arg Gly Asp Pro Ala Asn Val Glu Phe Thr Gln 
        275                 280                 285             


Leu Cys Ile Asp Leu Gly Trp Lys Pro Lys Tyr Gly Arg Phe Asp Val 
    290                 295                 300                 


Val Pro Leu Val Leu Gln Ala Asn Gly Arg Asp Pro Glu Leu Phe Glu 
305                 310                 315                 320 


Ile Pro Pro Asp Leu Val Leu Glu Val Ala Met Glu His Pro Lys Tyr 
                325                 330                 335     


Glu Trp Phe Arg Glu Leu Glu Leu Lys Trp Tyr Ala Leu Pro Ala Val 
            340                 345                 350         


Ala Asn Met Leu Leu Glu Val Gly Gly Leu Glu Phe Pro Gly Cys Pro 
        355                 360                 365             


Phe Asn Gly Trp Tyr Met Gly Thr Glu Ile Gly Val Arg Asp Phe Cys 
    370                 375                 380                 


Asp Val Gln Arg Tyr Asn Ile Leu Glu Glu Val Gly Arg Arg Met Gly 
385                 390                 395                 400 


Leu Glu Thr His Lys Leu Ala Ser Leu Trp Lys Asp Gln Ala Val Val 
                405                 410                 415     


Glu Ile Asn Ile Ala Val Leu His Ser Phe Gln Lys Gln Asn Val Thr 
            420                 425                 430         


Ile Met Asp His His Ser Ala Ala Glu Ser Phe Met Lys Tyr Met Gln 
        435                 440                 445             


Asn Glu Tyr Arg Ser Arg Gly Gly Cys Pro Ala Asp Trp Ile Trp Leu 
    450                 455                 460                 


Val Pro Pro Met Ser Gly Ser Ile Thr Pro Val Phe His Gln Glu Met 
465                 470                 475                 480 


Leu Asn Tyr Val Leu Ser Pro Phe Tyr Tyr Tyr Gln Val Glu Ala Trp 
                485                 490                 495     


Lys Thr His Val Trp Gln Asp Glu Lys Arg Arg Pro Lys Arg Arg Glu 
            500                 505                 510         


Ile Pro Leu Lys Val Leu Val Lys Ala Val Leu Phe Ala Cys Met Leu 
        515                 520                 525             


Met Arg Lys Thr Met Ala Ser Arg Val Arg Val Thr Ile Leu Phe Ala 
    530                 535                 540                 


Thr Glu Thr Gly Lys Ser Glu Ala Leu Ala Trp Asp Leu Gly Ala Leu 
545                 550                 555                 560 


Phe Ser Cys Ala Phe Asn Pro Lys Val Val Cys Met Asp Lys Tyr Arg 
                565                 570                 575     


Leu Ser Cys Leu Glu Glu Glu Arg Leu Leu Leu Val Val Thr Ser Thr 
            580                 585                 590         


Phe Gly Asn Gly Asp Cys Pro Gly Asn Gly Glu Lys Leu Lys Lys Ser 
        595                 600                 605             


Leu Phe Met Leu Lys Glu Leu Asn Asn Lys Phe Arg Tyr Ala Val Phe 
    610                 615                 620                 


Gly Leu Gly Ser Ser Met Tyr Pro Arg Phe Cys Ala Phe Ala His Asp 
625                 630                 635                 640 


Ile Asp Gln Lys Leu Ser His Leu Gly Ala Ser Gln Leu Thr Pro Met 
                645                 650                 655     


Gly Glu Gly Asp Glu Leu Ser Gly Gln Glu Asp Ala Phe Arg Ser Trp 
            660                 665                 670         


Ala Val Gln Thr Phe Lys Ala Ala Cys Glu Thr Phe Asp Val Arg Gly 
        675                 680                 685             


Lys Gln His Ile Gln Ile Pro Lys Leu Tyr Thr Ser Asn Val Thr Trp 
    690                 695                 700                 


Asp Pro His His Tyr Arg Leu Val Gln Asp Ser Gln Pro Leu Asp Leu 
705                 710                 715                 720 


Ser Lys Ala Leu Ser Ser Met His Ala Lys Asn Val Phe Thr Met Arg 
                725                 730                 735     


Leu Lys Ser Arg Gln Asn Leu Gln Ser Pro Thr Ser Ser Arg Ala Thr 
            740                 745                 750         


Ile Leu Val Glu Leu Ser Cys Glu Asp Gly Gln Gly Leu Asn Tyr Leu 
        755                 760                 765             


Pro Gly Glu His Leu Gly Val Cys Pro Gly Asn Gln Pro Ala Leu Val 
    770                 775                 780                 


Gln Gly Ile Leu Glu Arg Val Val Asp Gly Pro Thr Pro His Gln Thr 
785                 790                 795                 800 


Val Arg Leu Glu Ala Leu Asp Glu Ser Gly Ser Tyr Trp Val Ser Asp 
                805                 810                 815     


Lys Arg Leu Pro Pro Cys Ser Leu Ser Gln Ala Leu Thr Tyr Phe Leu 
            820                 825                 830         


Asp Ile Thr Thr Pro Pro Thr Gln Leu Leu Leu Gln Lys Leu Ala Gln 
        835                 840                 845             


Val Ala Thr Glu Glu Pro Glu Arg Gln Arg Leu Glu Ala Leu Cys Gln 
    850                 855                 860                 


Pro Ser Glu Tyr Ser Lys Trp Lys Phe Thr Asn Ser Pro Thr Phe Leu 
865                 870                 875                 880 


Glu Val Leu Glu Glu Phe Pro Ser Leu Arg Val Ser Ala Gly Phe Leu 
                885                 890                 895     


Leu Ser Gln Leu Pro Ile Leu Lys Pro Arg Phe Tyr Ser Ile Ser Ser 
            900                 905                 910         


Ser Arg Asp His Thr Pro Thr Glu Ile His Leu Thr Val Ala Val Val 
        915                 920                 925             


Thr Tyr His Thr Arg Asp Gly Gln Gly Pro Leu His His Gly Val Cys 
    930                 935                 940                 


Ser Thr Trp Leu Asn Ser Leu Lys Pro Gln Asp Pro Val Pro Cys Phe 
945                 950                 955                 960 


Val Arg Asn Ala Ser Gly Phe His Leu Pro Glu Asp Pro Ser His Pro 
                965                 970                 975     


Cys Ile Leu Ile Gly Pro Gly Thr Gly Ile Ala Pro Phe Arg Ser Phe 
            980                 985                 990         


Trp Gln Gln Arg Leu His Asp Ser  Gln His Lys Gly Val  Arg Gly Gly 
        995                 1000                 1005             


Arg Met  Thr Leu Val Phe Gly  Cys Arg Arg Pro Asp  Glu Asp His 
    1010                 1015                 1020             


Ile Tyr  Gln Glu Glu Met Leu  Glu Met Ala Gln Lys  Gly Val Leu 
    1025                 1030                 1035             


His Ala  Val His Thr Ala Tyr  Ser Arg Leu Pro Gly  Lys Pro Lys 
    1040                 1045                 1050             


Val Tyr  Val Gln Asp Ile Leu  Arg Gln Gln Leu Ala  Ser Glu Val 
    1055                 1060                 1065             


Leu Arg  Val Leu His Lys Glu  Pro Gly His Leu Tyr  Val Cys Gly 
    1070                 1075                 1080             


Asp Val  Arg Met Ala Arg Asp  Val Ala His Thr Leu  Lys Gln Leu 
    1085                 1090                 1095             


Val Ala  Ala Lys Leu Lys Leu  Asn Glu Glu Gln Val  Glu Asp Tyr 
    1100                 1105                 1110             


Phe Phe  Gln Leu Lys Ser Gln  Lys Arg Tyr His Glu  Asp Ile Phe 
    1115                 1120                 1125             


Gly Ala  Val Phe Pro Tyr Glu  Ala Lys Lys Asp Arg  Val Ala Val 
    1130                 1135                 1140             


Gln Pro  Ser Ser Leu Glu Met  Ser Ala Leu 
    1145                 1150             


<210> 37
<211> 2583
<212> DNA
<213> Homo sapiens

<400> 37
agccggtccc cgccgccgcc gcccttcgcg ccctgggcca tctccctccc acctccctcc       60

gcggagcagc cagacagcga gggccccggc cgggggcagg ggggacgccc cgtccggggc      120

acccccccgg ctctgagccg cccgcggggc cggcctcggc ccggagcgga ggaaggagtc      180

gccgaggagc agcctgaggc cccagagtct gagacgagcc gccgccgccc ccgccactgc      240

ggggaggagg gggaggagga gcgggaggag ggacgagctg gtcgggagaa gaggaaaaaa      300

acttttgaga cttttccgtt gccgctggga gccggaggcg cggggacctc ttggcgcgac      360

gctgccccgc gaggaggcag gacttgggga ccccagaccg cctccctttg ccgccgggga      420

cgcttgctcc ctccctgccc cctacacggc gtccctcagg cgcccccatt ccggaccagc      480

cctcgggagt cgccgacccg gcctcccgca aagacttttc cccagacctc gggcgcaccc      540

cctgcacgcc gccttcatcc ccggcctgtc tcctgagccc ccgcgcatcc tagacccttt      600

ctcctccagg agacggatct ctctccgacc tgccacagat cccctattca agaccaccca      660

ccttctggta ccagatcgcg cccatctagg ttatttccgt gggatactga gacacccccg      720

gtccaagcct cccctccacc actgcgccct tctccctgag gacctcagct ttccctcgag      780

gccctcctac cttttgccgg gagaccccca gcccctgcag gggcggggcc tccccaccac      840

accagccctg ttcgcgctct cggcagtgcc ggggggcgcc gcctccccca tgccgccctc      900

cgggctgcgg ctgctgccgc tgctgctacc gctgctgtgg ctactggtgc tgacgcctgg      960

ccggccggcc gcgggactat ccacctgcaa gactatcgac atggagctgg tgaagcggaa     1020

gcgcatcgag gccatccgcg gccagatcct gtccaagctg cggctcgcca gccccccgag     1080

ccagggggag gtgccgcccg gcccgctgcc cgaggccgtg ctcgccctgt acaacagcac     1140

ccgcgaccgg gtggccgggg agagtgcaga accggagccc gagcctgagg ccgactacta     1200

cgccaaggag gtcacccgcg tgctaatggt ggaaacccac aacgaaatct atgacaagtt     1260

caagcagagt acacacagca tatatatgtt cttcaacaca tcagagctcc gagaagcggt     1320

acctgaaccc gtgttgctct cccgggcaga gctgcgtctg ctgaggctca agttaaaagt     1380

ggagcagcac gtggagctgt accagaaata cagcaacaat tcctggcgat acctcagcaa     1440

ccggctgctg gcacccagcg actcgccaga gtggttatct tttgatgtca ccggagttgt     1500

gcggcagtgg ttgagccgtg gaggggaaat tgagggcttt cgccttagcg cccactgctc     1560

ctgtgacagc agggataaca cactgcaagt ggacatcaac gggttcacta ccggccgccg     1620

aggtgacctg gccaccattc atggcatgaa ccggcctttc ctgcttctca tggccacccc     1680

gctggagagg gcccagcatc tgcaaagctc ccggcaccgc cgagccctgg acaccaacta     1740

ttgcttcagc tccacggaga agaactgctg cgtgcggcag ctgtacattg acttccgcaa     1800

ggacctcggc tggaagtgga tccacgagcc caagggctac catgccaact tctgcctcgg     1860

gccctgcccc tacatttgga gcctggacac gcagtacagc aaggtcctgg ccctgtacaa     1920

ccagcataac ccgggcgcct cggcggcgcc gtgctgcgtg ccgcaggcgc tggagccgct     1980

gcccatcgtg tactacgtgg gccgcaagcc caaggtggag cagctgtcca acatgatcgt     2040

gcgctcctgc aagtgcagct gaggtcccgc cccgccccgc cccgccccgg caggcccggc     2100

cccaccccgc cccgcccccg ctgccttgcc catgggggct gtatttaagg acacccgtgc     2160

cccaagccca cctggggccc cattaaagat ggagagagga ctgcggatct ctgtgtcatt     2220

gggcgcctgc ctggggtctc catccctgac gttcccccac tcccactccc tctctctccc     2280

tctctgcctc ctcctgcctg tctgcactat tcctttgccc ggcatcaagg cacaggggac     2340

cagtggggaa cactactgta gttagatcta tttattgagc accttgggca ctgttgaagt     2400

gccttacatt aatgaactca ttcagtcacc atagcaacac tctgagatgc agggactctg     2460

ataacaccca ttttaaaggt gaggaaacaa gcccagagag gttaagggag gagttcctgc     2520

ccaccaggaa cctgctttag tgggggatag tgaagaagac aataaaagat agtagttcag     2580

gcc                                                                   2583


<210> 38
<211> 390
<212> PRT
<213> Homo sapiens

<400> 38
Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210> 39
<211> 2933
<212> DNA
<213> Homo sapiens

<400> 39
gcagacacct gggctgagac atacaggaca gagcatggat cgcctacaga ctgcactcct       60

ggttgtcctc gtcctccttg ctgtggcgct tcaagcaact gaggcaggcc cctacggcgc      120

caacatggaa gacagcgtct gctgccgtga ttacgtccgt taccgtctgc ccctgcgcgt      180

ggtgaaacac ttctactgga cctcagactc ctgcccgagg cctggcgtgg tgttgctaac      240

cttcagggat aaggagatct gtgccgatcc cagagtgccc tgggtgaaga tgattctcaa      300

taagctgagc caatgaagag cctactctga tgaccgtggc cttggctcct ccaggaaggc      360

tcaggagccc tacctccctg ccattatagc tgctccccgc cagaagcctg tgccaactct      420

ctgcattccc tgatctccat ccctgtggct gtcacccttg gtcacctccg tgctgtcact      480

gccatctccc ccctgacccc tctaacccat cctctgcctc cctccctgca gtcagagggt      540

cctgttccca tcagcgattc ccctgcttaa acccttccat gactccccac tgccctaagc      600

tgaggtcagt ctcccaagcc tggcatgtgg ccctctggat ctgggttcca tctctgtctc      660

cagcctgccc acttcccttc atgaatgttg ggttctagct ccctgttctc caaacccata      720

ctacacatcc cacttctggg tctttgcctg ggatgttgct gacacccaga aagtcccacc      780

acctgcacat gtgtagcccc accagccctc caaggcattg ctcgcccaag cagctggtaa      840

ttccatttca tgtattagat gtcccctggc cctctgtccc ctcttaataa ccctagtcac      900

agtctccgca gattcttggg atttgggggt tttctccccc acctctccac tagttggacc      960

aaggtttcta gctaagttac tctagtctcc aagcctctag catagagcac tgcagacagg     1020

ccctggctca gaatcagagc ccagaaagtg gctgcagaca aaatcaataa aactaatgtc     1080

cctcccctct ccctgccaaa aggcagttac atatcaatac agagactcaa ggtcactaga     1140

aatgggccag ctgggtcaat gtgaagcccc aaatttgccc agattcacct ttcttccccc     1200

actccctttt tttttttttt tttgagatgg agtttcgctc ttgtcaccca cgctggagtg     1260

caatggtgtg gtcttggctt attgaagcct ctgcctcctg ggttcaagtg attctcttgc     1320

ctcagcctcc tgagtagctg ggattacagg ttcctgctac cacgcccagc taatttttgt     1380

atttttagta gagacgaggc ttcaccatgt tggccaggct ggtctcgaac tcctgtcctc     1440

aggtaatccg cccacctcag cctcccaaag tgctgggatt acaggcgtga gccacagtgc     1500

ctggcctctt ccctctcccc accccccccc caactttttt ttttttttat ggcagggtct     1560

cactctgtcg cccaggctgg agtgcagtgg cgtgatctcg gctcactaca acctcgacct     1620

cctgggttca agcgattctc ccaccccagc ctcccaagta gctgggatta caggtgtgtg     1680

ccactacggc tggctaattt ttgtattttt agtagagaca ggtttcacca tattggccag     1740

gctggtcttg aactcctgac ctcaagtgat ccaccttcct tgtgctccca aagtgctgag     1800

attacaggcg tgagctatca cacccagcct cccccttttt ttcctaatag gagactcctg     1860

tacctttctt cgttttacct atgtgtcgtg tctgcttaca tttccttctc ccctcaggct     1920

ttttttgggt ggtcctccaa cctccaatac ccaggcctgg cctcttcaga gtacccccca     1980

ttccactttc cctgcctcct tccttaaata gctgacaatc aaattcatgc tatggtgtga     2040

aagactacct ttgacttggt attataagct ggagttatat atgtatttga aaacagagta     2100

aatacttaag aggccaaata gatgaatgga agaattttag gaactgtgag agggggacaa     2160

ggtggagctt tcctggccct gggaggaagc tggctgtggt agcgtagcgc tctctctctc     2220

tgtctgtggc aggaggcaaa gagtagggtg taattgagtg aaggaatcct gggtagagac     2280

cattctcagg tggttgggcc aggctaaaga ctgggatttg ggtctatcta tgcctttctg     2340

gctgattttt gtagagacgg ggttttgcca tgttacccag gctggtctca aactcctggg     2400

ctcaagcgat cctcctggct cagcctccca aagtgctggg attacaggcg tgagtcactg     2460

cgcctggctt cctcttcctc ttgagaaata ttcttttcat acagcaagta tgggacagca     2520

gtgtcccagg taaaggacat aaatgttaca agtgtctggt cctttctgag ggaggctggt     2580

gccgctctgc agggtatttg aacctgtgga attggaggag gccatttcac tccctgaacc     2640

cagcctgaca aatcacagtg agaatgttca ccttataggc ttgctgtggg gctcaggttg     2700

aaagtgtggg gagtgacact gcctaggcat ccagctcagt gtcatccagg gcctgtgtcc     2760

ctcccgaacc cagggtcaac ctgcctacca caggcactag aaggacgaat ctgcctactg     2820

cccatgaacg gggccctcaa gcgtcctggg atctccttct ccctcctgtc ctgtccttgc     2880

ccctcaggac tgctggaaaa taaatccttt aaaatagtaa aaaaaaaaaa aaa            2933


<210> 40
<211> 93
<212> PRT
<213> Homo sapiens

<400> 40
Met Asp Arg Leu Gln Thr Ala Leu Leu Val Val Leu Val Leu Leu Ala 
1               5                   10                  15      


Val Ala Leu Gln Ala Thr Glu Ala Gly Pro Tyr Gly Ala Asn Met Glu 
            20                  25                  30          


Asp Ser Val Cys Cys Arg Asp Tyr Val Arg Tyr Arg Leu Pro Leu Arg 
        35                  40                  45              


Val Val Lys His Phe Tyr Trp Thr Ser Asp Ser Cys Pro Arg Pro Gly 
    50                  55                  60                  


Val Val Leu Leu Thr Phe Arg Asp Lys Glu Ile Cys Ala Asp Pro Arg 
65                  70                  75                  80  


Val Pro Trp Val Lys Met Ile Leu Asn Lys Leu Ser Gln 
                85                  90              


<210> 41
<211> 1567
<212> DNA
<213> Mus musculus

<400> 41
aaaaagccag cagaagctct ccagaagcaa tcctgaagac accatggcca agctcattct       60

tgtcacaggt ctggcaattc ttctgaacgt acagctggga tcttcctacc agctgatgtg      120

ctactatacc agttgggcta aggacaggcc aatagaaggg agtttcaaac ctggtaatat      180

tgacccctgc ctgtgtactc acctgatcta tgcctttgct ggaatgcaga ataatgagat      240

cacttacaca catgagcaag acttgcgtga ctatgaagca ttgaatggtc tgaaagacaa      300

gaacactgag ctaaaaactc tcctggccat tggaggatgg aagtttggac ctgccccgtt      360

cagtgccatg gtctctactc ctcagaaccg tcagatattc attcagtcag ttatcagatt      420

ccttcgtcaa tataactttg atggcctcaa cctggactgg cagtaccctg ggtctcgagg      480

aagccctcct aaggacaaac atctcttcag tgttctggtg aaggaaatgc gtaaagcttt      540

tgaggaagaa tctgtggaga aagacattcc aaggctgcta ctcacttcca caggagcagg      600

aatcattgac gtaatcaagt ctgggtacaa gatccctgaa ctgtctcagt ctcttgacta      660

tattcaggtc atgacatatg atctccatga tcctaaggat ggctacactg gagaaaatag      720

tcccctctat aaatctccat atgacattgg aaagagtgct gatctcaatg tggattcaat      780

catttcctac tggaaggacc atggagcagc ttctgagaag ctcattgtgg gatttccagc      840

atatgggcat acctttatcc tgagtgaccc ttctaagact ggaattggtg cccctacaat      900

tagtactggc ccaccaggaa agtacacaga tgaatcagga ctcctggctt actatgaggt      960

ttgtacattt ctgaatgaag gagccactga ggtctgggat gccccccagg aagtacccta     1020

tgcctatcag ggtaatgagt gggttggtta tgacaatgtc aggagcttca agttgaaggc     1080

tcagtggctc aaggacaaca atttaggagg tgccgtggtc tggcccctgg acatggatga     1140

cttcagtggt tctttctgtc accagagaca tttccctctg acatctactt taaagggaga     1200

tctcaatata cacagtgcaa gttgcaaggg cccttattga gaggagcttt acacaatgat     1260

ttgtccttga aactctcaga ataagatcaa gttcaacggt ttttccacag tgcattctgc     1320

atcatgcttc catggagaat aatagaaata agtcatgaac tttcctaaat tgaatcccag     1380

agtagtacta agatggatgt cttgtctgct gtaccagctg ggaagaaaca aaaaatgctc     1440

ttcatctgtc agctttggct aagctctgaa catcttttgc ttcctgtaaa accaccatgc     1500

ttgtttcttg ctctcacaat aaattccaca ttcatagcaa aaaaaaaaaa aaaaaaaaaa     1560

aaaaaaa                                                               1567


<210> 42
<211> 398
<212> PRT
<213> Mus musculus

<400> 42
Met Ala Lys Leu Ile Leu Val Thr Gly Leu Ala Ile Leu Leu Asn Val 
1               5                   10                  15      


Gln Leu Gly Ser Ser Tyr Gln Leu Met Cys Tyr Tyr Thr Ser Trp Ala 
            20                  25                  30          


Lys Asp Arg Pro Ile Glu Gly Ser Phe Lys Pro Gly Asn Ile Asp Pro 
        35                  40                  45              


Cys Leu Cys Thr His Leu Ile Tyr Ala Phe Ala Gly Met Gln Asn Asn 
    50                  55                  60                  


Glu Ile Thr Tyr Thr His Glu Gln Asp Leu Arg Asp Tyr Glu Ala Leu 
65                  70                  75                  80  


Asn Gly Leu Lys Asp Lys Asn Thr Glu Leu Lys Thr Leu Leu Ala Ile 
                85                  90                  95      


Gly Gly Trp Lys Phe Gly Pro Ala Pro Phe Ser Ala Met Val Ser Thr 
            100                 105                 110         


Pro Gln Asn Arg Gln Ile Phe Ile Gln Ser Val Ile Arg Phe Leu Arg 
        115                 120                 125             


Gln Tyr Asn Phe Asp Gly Leu Asn Leu Asp Trp Gln Tyr Pro Gly Ser 
    130                 135                 140                 


Arg Gly Ser Pro Pro Lys Asp Lys His Leu Phe Ser Val Leu Val Lys 
145                 150                 155                 160 


Glu Met Arg Lys Ala Phe Glu Glu Glu Ser Val Glu Lys Asp Ile Pro 
                165                 170                 175     


Arg Leu Leu Leu Thr Ser Thr Gly Ala Gly Ile Ile Asp Val Ile Lys 
            180                 185                 190         


Ser Gly Tyr Lys Ile Pro Glu Leu Ser Gln Ser Leu Asp Tyr Ile Gln 
        195                 200                 205             


Val Met Thr Tyr Asp Leu His Asp Pro Lys Asp Gly Tyr Thr Gly Glu 
    210                 215                 220                 


Asn Ser Pro Leu Tyr Lys Ser Pro Tyr Asp Ile Gly Lys Ser Ala Asp 
225                 230                 235                 240 


Leu Asn Val Asp Ser Ile Ile Ser Tyr Trp Lys Asp His Gly Ala Ala 
                245                 250                 255     


Ser Glu Lys Leu Ile Val Gly Phe Pro Ala Tyr Gly His Thr Phe Ile 
            260                 265                 270         


Leu Ser Asp Pro Ser Lys Thr Gly Ile Gly Ala Pro Thr Ile Ser Thr 
        275                 280                 285             


Gly Pro Pro Gly Lys Tyr Thr Asp Glu Ser Gly Leu Leu Ala Tyr Tyr 
    290                 295                 300                 


Glu Val Cys Thr Phe Leu Asn Glu Gly Ala Thr Glu Val Trp Asp Ala 
305                 310                 315                 320 


Pro Gln Glu Val Pro Tyr Ala Tyr Gln Gly Asn Glu Trp Val Gly Tyr 
                325                 330                 335     


Asp Asn Val Arg Ser Phe Lys Leu Lys Ala Gln Trp Leu Lys Asp Asn 
            340                 345                 350         


Asn Leu Gly Gly Ala Val Val Trp Pro Leu Asp Met Asp Asp Phe Ser 
        355                 360                 365             


Gly Ser Phe Cys His Gln Arg His Phe Pro Leu Thr Ser Thr Leu Lys 
    370                 375                 380                 


Gly Asp Leu Asn Ile His Ser Ala Ser Cys Lys Gly Pro Tyr 
385                 390                 395             


<210> 43
<211> 594
<212> DNA
<213> Homo sapiens

<400> 43
ccacgttgtc ttctttcctt caccaccacc caggagctca gagatctaag ctgctttcca       60

tcttttctcc cagccccagg acactgactc tgtacaggat ggggccgtcc tcttgcctcc      120

ttctcatcct aatccccctt ctccagctga tcaacccggg gagtactcag tgttccttag      180

actccgttat ggataagaag atcaaggatg ttctcaacag tctagagtac agtccctctc      240

ctataagcaa gaagctctcg tgtgctagtg tcaaaagcca aggcagaccg tcctcctgcc      300

ctgctgggat ggctgtcact ggctgtgctt gtggctatgg ctgtggttcg tgggatgttc      360

agctggaaac cacctgccac tgccagtgca gtgtggtgga ctggaccact gcccgctgct      420

gccacctgac ctgacaggga ggaggctgag aactcagttt tgtgaccatg acagtaatga      480

aaccagggtc ccaaccaaga aatctaactc aaacgtccca cttcatttgt tccattcctg      540

attcttgggt aataaagaca aactttgtac ctcaaaaaaa aaaaaaaaaa aaaa            594


<210> 44
<211> 111
<212> PRT
<213> Homo sapiens

<400> 44
Met Gly Pro Ser Ser Cys Leu Leu Leu Ile Leu Ile Pro Leu Leu Gln 
1               5                   10                  15      


Leu Ile Asn Pro Gly Ser Thr Gln Cys Ser Leu Asp Ser Val Met Asp 
            20                  25                  30          


Lys Lys Ile Lys Asp Val Leu Asn Ser Leu Glu Tyr Ser Pro Ser Pro 
        35                  40                  45              


Ile Ser Lys Lys Leu Ser Cys Ala Ser Val Lys Ser Gln Gly Arg Pro 
    50                  55                  60                  


Ser Ser Cys Pro Ala Gly Met Ala Val Thr Gly Cys Ala Cys Gly Tyr 
65                  70                  75                  80  


Gly Cys Gly Ser Trp Asp Val Gln Leu Glu Thr Thr Cys His Cys Gln 
                85                  90                  95      


Cys Ser Val Val Asp Trp Thr Thr Ala Arg Cys Cys His Leu Thr 
            100                 105                 110     


<210> 45
<211> 1499
<212> DNA
<213> Homo sapiens

<400> 45
ggaaaaaaaa gatgcgccct ctgtcactga gggttgactg actggagagc tcaagtgcag       60

caaagagaag tgtcagagca tgagcgccaa gtccagaacc atagggatta ttggagctcc      120

tttctcaaag ggacagccac gaggaggggt ggaagaaggc cctacagtat tgagaaaggc      180

tggtctgctt gagaaactta aagaacaagt aactcaaaac tttttaattt tagagtgtga      240

tgtgaaggat tatggggacc tgccctttgc tgacatccct aatgacagtc cctttcaaat      300

tgtgaagaat ccaaggtctg tgggaaaagc aagcgagcag ctggctggca aggtggcaga      360

agtcaagaag aacggaagaa tcagcctggt gctgggcgga gaccacagtt tggcaattgg      420

aagcatctct ggccatgcca gggtccaccc tgatcttgga gtcatctggg tggatgctca      480

cactgatatc aacactccac tgacaaccac aagtggaaac ttgcatggac aacctgtatc      540

tttcctcctg aaggaactaa aaggaaagat tcccgatgtg ccaggattct cctgggtgac      600

tccctgtata tctgccaagg atattgtgta tattggcttg agagacgtgg accctgggga      660

acactacatt ttgaaaactc taggcattaa atacttttca atgactgaag tggacagact      720

aggaattggc aaggtgatgg aagaaacact cagctatcta ctaggaagaa agaaaaggcc      780

aattcatcta agttttgatg ttgacggact ggacccatct ttcacaccag ctactggcac      840

accagtcgtg ggaggtctga catacagaga aggtctctac atcacagaag aaatctacaa      900

aacagggcta ctctcaggat tagatataat ggaagtgaac ccatccctgg ggaagacacc      960

agaagaagta actcgaacag tgaacacagc agttgcaata accttggctt gtttcggact     1020

tgctcgggag ggtaatcaca agcctattga ctaccttaac ccacctaagt aaatgtggaa     1080

acatccgata taaatctcat agttaatggc ataattagaa agctaatcat tttcttaagc     1140

atagagttat ccttctaaag acttgttctt tcagaaaaat gtttttccaa ttagtataaa     1200

ctctacaaat tccctcttgg tgtaaaattc aagatgtgga aattctaact tttttgaaat     1260

ttaaaagctt atattttcta acttggcaaa agacttatcc ttagaaagag aagtgtacat     1320

tgatttccaa ttaaaaattt gctggcatta aaaataagca cacttacata agcccccata     1380

catagagtgg gactcttgga atcaggagac aaagctacca catgtggaaa ggtactatgt     1440

gtccatgtca ttcaaaaaat gtgatttttt ataataaact ctttataaca agattaaaa      1499


<210> 46
<211> 330
<212> PRT
<213> Homo sapiens

<400> 46
Met Ser Ala Lys Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser 
1               5                   10                  15      


Lys Gly Gln Pro Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg 
            20                  25                  30          


Lys Ala Gly Leu Leu Glu Lys Leu Lys Glu Gln Val Thr Gln Asn Phe 
        35                  40                  45              


Leu Ile Leu Glu Cys Asp Val Lys Asp Tyr Gly Asp Leu Pro Phe Ala 
    50                  55                  60                  


Asp Ile Pro Asn Asp Ser Pro Phe Gln Ile Val Lys Asn Pro Arg Ser 
65                  70                  75                  80  


Val Gly Lys Ala Ser Glu Gln Leu Ala Gly Lys Val Ala Glu Val Lys 
                85                  90                  95      


Lys Asn Gly Arg Ile Ser Leu Val Leu Gly Gly Asp His Ser Leu Ala 
            100                 105                 110         


Ile Gly Ser Ile Ser Gly His Ala Arg Val His Pro Asp Leu Gly Val 
        115                 120                 125             


Ile Trp Val Asp Ala His Thr Asp Ile Asn Thr Pro Leu Thr Thr Thr 
    130                 135                 140                 


Ser Gly Asn Leu His Gly Gln Pro Val Ser Phe Leu Leu Lys Glu Leu 
145                 150                 155                 160 


Lys Gly Lys Ile Pro Asp Val Pro Gly Phe Ser Trp Val Thr Pro Cys 
                165                 170                 175     


Ile Ser Ala Lys Asp Ile Val Tyr Ile Gly Leu Arg Asp Val Asp Pro 
            180                 185                 190         


Gly Glu His Tyr Ile Leu Lys Thr Leu Gly Ile Lys Tyr Phe Ser Met 
        195                 200                 205             


Thr Glu Val Asp Arg Leu Gly Ile Gly Lys Val Met Glu Glu Thr Leu 
    210                 215                 220                 


Ser Tyr Leu Leu Gly Arg Lys Lys Arg Pro Ile His Leu Ser Phe Asp 
225                 230                 235                 240 


Val Asp Gly Leu Asp Pro Ser Phe Thr Pro Ala Thr Gly Thr Pro Val 
                245                 250                 255     


Val Gly Gly Leu Thr Tyr Arg Glu Gly Leu Tyr Ile Thr Glu Glu Ile 
            260                 265                 270         


Tyr Lys Thr Gly Leu Leu Ser Gly Leu Asp Ile Met Glu Val Asn Pro 
        275                 280                 285             


Ser Leu Gly Lys Thr Pro Glu Glu Val Thr Arg Thr Val Asn Thr Ala 
    290                 295                 300                 


Val Ala Ile Thr Leu Ala Cys Phe Gly Leu Ala Arg Glu Gly Asn His 
305                 310                 315                 320 


Lys Pro Ile Asp Tyr Leu Asn Pro Pro Lys 
                325                 330 


<210> 47
<211> 5582
<212> DNA
<213> Homo sapiens

<400> 47
agatctgccc tgtagagcct tgcggttcca ctgctggcct ccggattccc gggagccccc       60

agcccgacag gacaaccttc cttccccgct tcctcctttc cagacccggc ggcaggagag      120

gggatgaaga tggcggacgc gaagcagaag cggaacgagc agctgaaacg ctggatcggc      180

tccgagacgg acctcgagcc tccggtggtg aagcgccaga agaccaaggt gaagttcgac      240

gatggcgccg tcttcctggc tgcttgctcc agcggcgaca cggacgaggt cctcaagctg      300

ctgcaccgcg gcgccgacat caattacgcc aatgtggacg gactcactgc cctgcaccag      360

gcttgcattg atgacaatgt tgatatggtg aagtttctgg tagaaaatgg agcaaatatt      420

aatcaacctg ataatgaagg ctggatacca ctacatgcag cagcttcctg tggatatctt      480

gatattgcag agtttttgat tggtcaagga gcacatgtag gggctgtcaa cagtgaagga      540

gatacacctt tagatattgc ggaggaggag gcaatggaag agctacttca aaatgaagtt      600

aatcggcaag gggttgatat agaagcagct cgaaaggaag aagaacggat catgcttaga      660

gatgccaggc agtggctaaa tagtggtcat ataaatgatg tccggcatgc aaaatctgga      720

ggtacagcac ttcacgttgc agctgctaaa ggctatacgg aagttttaaa acttttaata      780

caggcaggct atgatgttaa tattaaagac tatgatggct ggacacctct tcatgctgca      840

gctcattggg gtaaagaaga agcatgtcga attttagtgg acaatctgtg tgatatggag      900

atggtcaaca aagtgggcca aacagccttt gatgtagcag atgaagacat tttaggatat      960

ttagaagagt tgcaaaagaa acaaaatctg ctccatagtg aaaaacggga caagaaatct     1020

ccactaattg aatcaacagc aaatatggac aataatcagt cacagaagac ctttaaaaac     1080

aaagagacgt tgattattga accagagaaa aatgcatccc gtattgaatc tctggaacaa     1140

gaaaaggttg atgaagaaga agaaggaaag aaggatgagt ctagctgctc tagtgaagaa     1200

gatgaggaag atgactcgga atcagaagct gaaacagata agacaaaacc cctggcttct     1260

gtaactaatg ccaacacttc tagtacacaa gcagctcctg tagctgttac aacacctact     1320

gtgtcatcag gtcaagcaac acctacatca cctattaaaa agtttccaac cacagctaca     1380

aaaatttctc ccaaagaaga agagagaaaa gatgagtctc ctgcaacttg gaggttagga     1440

cttagaaaga cgggcagcta tggtgcactt gctgaaatca cagcatctaa agagggtcag     1500

aaagaaaaag atactgcagg tgttacacgt tcagcttcaa gtcccagact ttcctcctct     1560

ttggataata aagaaaagga gaaagatagt aaaggaacta ggcttgcata tgttgcacct     1620

acaataccaa gacgactagc cagtacatct gacattgaag agaaagaaaa cagagattct     1680

tcaagtttgc gaacaagtag ttcatataca aggagaaaat gggaagatga tcttaaaaaa     1740

aatagctcag ttaatgaagg atcaacgtat cataaaagtt gctcctttgg tagaagacaa     1800

gatgatttga ttagttctag tgttccaagc accacatcaa caccaacagt tacctctgca     1860

gctgggcttc agaaaagcct gctttccagc acaagcacta ctacaaagat tacaacgggt     1920

tcttcctcag caggcacaca aagcagtacc tcaaatcgtt tgtgggctga ggatagtact     1980

gagaaagaaa aggacagtgt tcctacggca gtgaccattc ctgttgctcc aactgttgta     2040

aatgctgcag cttctaccac aaccctgact acaactactg ctggcactgt ctcctccaca     2100

acagaggtca gggagagacg cagatcatac ctcactcctg ttagggatga agagtctgaa     2160

tcccaaagaa aagcaagatc tagacaagca agacaatcta gaagatcaac acagggagtg     2220

acattaactg atcttcaaga agctgagaaa acaataggaa gaagtcgttc tacccgaacc     2280

agagaacaag aaaatgaaga aaaagaaaaa gaggaaaaag agaaacaaga taaagagaaa     2340

caagaagaaa agaaggagtc agaaacatct agagaagatg aatataaaca aaagtactcc     2400

agaacgtatg atgagactta ccagcgttat aggccagtat caacttcaag ttcaaccact     2460

ccatcctctt cactttctac tatgagcagt tcactgtatg cttcaagtca actaaacagg     2520

ccaaatagtc ttgtaggcat aacttctgct tactccagag gaataacaaa agaaaatgaa     2580

agagagggag aaaaaagaga agaggagaaa gaaggagaag ataaatcaca acctaaatca     2640

atcagagaac gacgacgacc aagagagaaa agaagatcta caggagtttc attttggaca     2700

caagatagtg atgaaaatga acaagaacaa caatcagaca cagaagaggg atccaataag     2760

aaagaaactc agacggattc catttctaga tatgaaacca gttctacatc agctggtgat     2820

cgatatgatt ccttgctggg tcgctctgga tcatacagtt acttagaaga aagaaaacct     2880

tacagcagca ggctagaaaa ggatgactca actgacttta aaaagcttta tgaacaaatt     2940

ctagctgaaa atgaaaagct gaaggcacag ctacatgata caaatatgga actaacagat     3000

cttaaattac agttggaaaa ggccacccag agacaagaaa gatttgctga tagatcactg     3060

ttggaaatgg aaaaaaggga acgaagagct ctagaaagaa gaatatctga aatggaagaa     3120

gagctcaaaa tgttaccaga cctaaaagca gacaaccaga ggctaaagga tgaaaatggg     3180

gccttgatca gagttataag caaactttcc aaataaaaaa aaaaaaagca gcaagtaatg     3240

gaattgcaca tattagtaac ccagtggacc ataattggca gtcactggaa gtctgggaag     3300

aatccttgga gactgtcatt ttcggatatc ctgccaaatg ccctcttatc tagaattttt     3360

gtttcatttt gtttaatttt ctggggtgtt tttgttgttg ttggtttgtt ttttgttttt     3420

tttttttaat caagaccatt gtttcatgtt aatgcagctg ctgagaagat ttttttttaa     3480

tgactgagaa aacttgttta cagctccagc atataaggaa agtgttcaag gccagatatg     3540

cctcagatat ttaaccagta agccttagtt gtacataaat acttttgtgt caacaaaaac     3600

tttcagctct cacagaagac agttactcaa cattttttga tgtgccacag tttcgagttt     3660

ttcgatattt aaattttttg gcttttcatc taagtttggg tttgtatttt ttccttctaa     3720

actcttcatg tggcagagtc ttctatgttt tcacagcttt ttcattacag aaaagaacac     3780

ttgctcttct gtgattattg tcatgtatta ggctaatgct gtgttgtctc ccacctggaa     3840

ctgaattgct tggtggaaca tatgctttca ctgtttgtgc aatatgcatt tatttcttat     3900

atgaatgctt taaagtcatt tgaggttaga tcttttaatt cctattttct gcttcattgg     3960

tcactttttt tttattgtag tataagatgt tagattctgt aatcttcaca ttcattttag     4020

caggtactga gtgatgctgt atatacaaat aagtgtattg ttttgatttt tagaccacca     4080

catggcatgc ttgactattt cttatttcaa atgtctgcta atgcagagta ggctactcca     4140

tgatagtgtt aaaaaacaaa atttgctaac aatgtgatat aaagacttta aaagttacac     4200

attatgtgga gccctatctt tacaaaagtt tcctactgta aagtgctttt attttcagtt     4260

ttcacttgat agtactcaac cataattaaa gttgcataag ataattgctt tacatttcac     4320

atacctatat ttatctgagt gctgtctaaa actgttgtgc tagccaaagt aatgctatga     4380

aatcatttgc agaattaacc cgtgagttaa tgttaaatgc actgttattg ccatgtgaag     4440

aggcatcgac tttgatacca ccatcatgtt cagaccattt tatacatttc agtggccttt     4500

tttttttttt aaggaaaaaa aagcgcaaaa ccaagtacat agtgacgatg gcttttattt     4560

ggacaaatag cttttatatt ttcattaaac catgcaaaaa atactacatc tttctggcac     4620

ataactgtct ccttaaccac tgaacagttc agccatttga ataaattgta cattgtaaag     4680

cttatagtag ctgattgtat tattgattgt attgtatact atattaaatg tgaatttgta     4740

ccccttcatt ttaaaaggtc attgtgttct actgcctatt ttagattact ttggggttgg     4800

ggaagggtgt tttggtaagc aggattttaa gtcctctctc tctcgattgg ttttatgaag     4860

atataaggtt atgctcttac taccaagctc aggattcttg attttaaagg tacaaggata     4920

gttgtgggag ttttattttt ggttatattt gaactgtatg aatggtaggt ctgaatattg     4980

agaatttcca tggtcttatg tggaggtaaa atatacagat aactgatcag tttgagtgac     5040

tgcaacatgt tctggttgca caacagttag gcatgctatg gtttatattt gtgaagtttg     5100

gatgcctgtg aagaatgatt aaatacatgt ttctaatatt ttagtgtttt gtatttaggt     5160

tatttattct ttgtatctaa aactgaacag ctactgtgct atattgattt tattggtagt     5220

attgagcaga ccttgtttct gcatgaaact agttgcaaaa cccactattt tggaaataaa     5280

aatgtatttt gacatataca aataaaatga ataaaactat tttaaatgtg tgaactttta     5340

atgaagacat tttaaatttt gttctgagat atttaaattc tgcatgggta ttttttcact     5400

aattgcttta cttggatacc aatttgaata atttctgaaa ttgtaatatt gtgataattt     5460

gcacagcatt gtacatgcac atctgtaaat gcaatcttaa ttgccatatt tatgcaatct     5520

gtgtaccaat ttggacaaat gtttatatat tttacataaa gctgtctgta tgcagaatct     5580

ga                                                                    5582


<210> 48
<211> 1030
<212> PRT
<213> Homo sapiens

<400> 48
Met Lys Met Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg 
1               5                   10                  15      


Trp Ile Gly Ser Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg Gln 
            20                  25                  30          


Lys Thr Lys Val Lys Phe Asp Asp Gly Ala Val Phe Leu Ala Ala Cys 
        35                  40                  45              


Ser Ser Gly Asp Thr Asp Glu Val Leu Lys Leu Leu His Arg Gly Ala 
    50                  55                  60                  


Asp Ile Asn Tyr Ala Asn Val Asp Gly Leu Thr Ala Leu His Gln Ala 
65                  70                  75                  80  


Cys Ile Asp Asp Asn Val Asp Met Val Lys Phe Leu Val Glu Asn Gly 
                85                  90                  95      


Ala Asn Ile Asn Gln Pro Asp Asn Glu Gly Trp Ile Pro Leu His Ala 
            100                 105                 110         


Ala Ala Ser Cys Gly Tyr Leu Asp Ile Ala Glu Phe Leu Ile Gly Gln 
        115                 120                 125             


Gly Ala His Val Gly Ala Val Asn Ser Glu Gly Asp Thr Pro Leu Asp 
    130                 135                 140                 


Ile Ala Glu Glu Glu Ala Met Glu Glu Leu Leu Gln Asn Glu Val Asn 
145                 150                 155                 160 


Arg Gln Gly Val Asp Ile Glu Ala Ala Arg Lys Glu Glu Glu Arg Ile 
                165                 170                 175     


Met Leu Arg Asp Ala Arg Gln Trp Leu Asn Ser Gly His Ile Asn Asp 
            180                 185                 190         


Val Arg His Ala Lys Ser Gly Gly Thr Ala Leu His Val Ala Ala Ala 
        195                 200                 205             


Lys Gly Tyr Thr Glu Val Leu Lys Leu Leu Ile Gln Ala Gly Tyr Asp 
    210                 215                 220                 


Val Asn Ile Lys Asp Tyr Asp Gly Trp Thr Pro Leu His Ala Ala Ala 
225                 230                 235                 240 


His Trp Gly Lys Glu Glu Ala Cys Arg Ile Leu Val Asp Asn Leu Cys 
                245                 250                 255     


Asp Met Glu Met Val Asn Lys Val Gly Gln Thr Ala Phe Asp Val Ala 
            260                 265                 270         


Asp Glu Asp Ile Leu Gly Tyr Leu Glu Glu Leu Gln Lys Lys Gln Asn 
        275                 280                 285             


Leu Leu His Ser Glu Lys Arg Asp Lys Lys Ser Pro Leu Ile Glu Ser 
    290                 295                 300                 


Thr Ala Asn Met Asp Asn Asn Gln Ser Gln Lys Thr Phe Lys Asn Lys 
305                 310                 315                 320 


Glu Thr Leu Ile Ile Glu Pro Glu Lys Asn Ala Ser Arg Ile Glu Ser 
                325                 330                 335     


Leu Glu Gln Glu Lys Val Asp Glu Glu Glu Glu Gly Lys Lys Asp Glu 
            340                 345                 350         


Ser Ser Cys Ser Ser Glu Glu Asp Glu Glu Asp Asp Ser Glu Ser Glu 
        355                 360                 365             


Ala Glu Thr Asp Lys Thr Lys Pro Leu Ala Ser Val Thr Asn Ala Asn 
    370                 375                 380                 


Thr Ser Ser Thr Gln Ala Ala Pro Val Ala Val Thr Thr Pro Thr Val 
385                 390                 395                 400 


Ser Ser Gly Gln Ala Thr Pro Thr Ser Pro Ile Lys Lys Phe Pro Thr 
                405                 410                 415     


Thr Ala Thr Lys Ile Ser Pro Lys Glu Glu Glu Arg Lys Asp Glu Ser 
            420                 425                 430         


Pro Ala Thr Trp Arg Leu Gly Leu Arg Lys Thr Gly Ser Tyr Gly Ala 
        435                 440                 445             


Leu Ala Glu Ile Thr Ala Ser Lys Glu Gly Gln Lys Glu Lys Asp Thr 
    450                 455                 460                 


Ala Gly Val Thr Arg Ser Ala Ser Ser Pro Arg Leu Ser Ser Ser Leu 
465                 470                 475                 480 


Asp Asn Lys Glu Lys Glu Lys Asp Ser Lys Gly Thr Arg Leu Ala Tyr 
                485                 490                 495     


Val Ala Pro Thr Ile Pro Arg Arg Leu Ala Ser Thr Ser Asp Ile Glu 
            500                 505                 510         


Glu Lys Glu Asn Arg Asp Ser Ser Ser Leu Arg Thr Ser Ser Ser Tyr 
        515                 520                 525             


Thr Arg Arg Lys Trp Glu Asp Asp Leu Lys Lys Asn Ser Ser Val Asn 
    530                 535                 540                 


Glu Gly Ser Thr Tyr His Lys Ser Cys Ser Phe Gly Arg Arg Gln Asp 
545                 550                 555                 560 


Asp Leu Ile Ser Ser Ser Val Pro Ser Thr Thr Ser Thr Pro Thr Val 
                565                 570                 575     


Thr Ser Ala Ala Gly Leu Gln Lys Ser Leu Leu Ser Ser Thr Ser Thr 
            580                 585                 590         


Thr Thr Lys Ile Thr Thr Gly Ser Ser Ser Ala Gly Thr Gln Ser Ser 
        595                 600                 605             


Thr Ser Asn Arg Leu Trp Ala Glu Asp Ser Thr Glu Lys Glu Lys Asp 
    610                 615                 620                 


Ser Val Pro Thr Ala Val Thr Ile Pro Val Ala Pro Thr Val Val Asn 
625                 630                 635                 640 


Ala Ala Ala Ser Thr Thr Thr Leu Thr Thr Thr Thr Ala Gly Thr Val 
                645                 650                 655     


Ser Ser Thr Thr Glu Val Arg Glu Arg Arg Arg Ser Tyr Leu Thr Pro 
            660                 665                 670         


Val Arg Asp Glu Glu Ser Glu Ser Gln Arg Lys Ala Arg Ser Arg Gln 
        675                 680                 685             


Ala Arg Gln Ser Arg Arg Ser Thr Gln Gly Val Thr Leu Thr Asp Leu 
    690                 695                 700                 


Gln Glu Ala Glu Lys Thr Ile Gly Arg Ser Arg Ser Thr Arg Thr Arg 
705                 710                 715                 720 


Glu Gln Glu Asn Glu Glu Lys Glu Lys Glu Glu Lys Glu Lys Gln Asp 
                725                 730                 735     


Lys Glu Lys Gln Glu Glu Lys Lys Glu Ser Glu Thr Ser Arg Glu Asp 
            740                 745                 750         


Glu Tyr Lys Gln Lys Tyr Ser Arg Thr Tyr Asp Glu Thr Tyr Gln Arg 
        755                 760                 765             


Tyr Arg Pro Val Ser Thr Ser Ser Ser Thr Thr Pro Ser Ser Ser Leu 
    770                 775                 780                 


Ser Thr Met Ser Ser Ser Leu Tyr Ala Ser Ser Gln Leu Asn Arg Pro 
785                 790                 795                 800 


Asn Ser Leu Val Gly Ile Thr Ser Ala Tyr Ser Arg Gly Ile Thr Lys 
                805                 810                 815     


Glu Asn Glu Arg Glu Gly Glu Lys Arg Glu Glu Glu Lys Glu Gly Glu 
            820                 825                 830         


Asp Lys Ser Gln Pro Lys Ser Ile Arg Glu Arg Arg Arg Pro Arg Glu 
        835                 840                 845             


Lys Arg Arg Ser Thr Gly Val Ser Phe Trp Thr Gln Asp Ser Asp Glu 
    850                 855                 860                 


Asn Glu Gln Glu Gln Gln Ser Asp Thr Glu Glu Gly Ser Asn Lys Lys 
865                 870                 875                 880 


Glu Thr Gln Thr Asp Ser Ile Ser Arg Tyr Glu Thr Ser Ser Thr Ser 
                885                 890                 895     


Ala Gly Asp Arg Tyr Asp Ser Leu Leu Gly Arg Ser Gly Ser Tyr Ser 
            900                 905                 910         


Tyr Leu Glu Glu Arg Lys Pro Tyr Ser Ser Arg Leu Glu Lys Asp Asp 
        915                 920                 925             


Ser Thr Asp Phe Lys Lys Leu Tyr Glu Gln Ile Leu Ala Glu Asn Glu 
    930                 935                 940                 


Lys Leu Lys Ala Gln Leu His Asp Thr Asn Met Glu Leu Thr Asp Leu 
945                 950                 955                 960 


Lys Leu Gln Leu Glu Lys Ala Thr Gln Arg Gln Glu Arg Phe Ala Asp 
                965                 970                 975     


Arg Ser Leu Leu Glu Met Glu Lys Arg Glu Arg Arg Ala Leu Glu Arg 
            980                 985                 990         


Arg Ile Ser Glu Met Glu Glu Glu  Leu Lys Met Leu Pro  Asp Leu Lys 
        995                 1000                 1005             


Ala Asp  Asn Gln Arg Leu Lys  Asp Glu Asn Gly Ala  Leu Ile Arg 
    1010                 1015                 1020             


Val Ile  Ser Lys Leu Ser Lys  
    1025                 1030 


<210> 49
<211> 1579
<212> DNA
<213> Homo sapiens

<400> 49
agcccacagc agtccgtgcc gccgtcccgc ccgccagcgc cccagcgagg aagcagcgcg       60

cagcccgcgg cccagcgcac ccgcagcagc gcccgcagct cgtccgcgcc atgttccagg      120

cggccgagcg cccccaggag tgggccatgg agggcccccg cgacgggctg aagaaggagc      180

ggctactgga cgaccgccac gacagcggcc tggactccat gaaagacgag gagtacgagc      240

agatggtcaa ggagctgcag gagatccgcc tcgagccgca ggaggtgccg cgcggctcgg      300

agccctggaa gcagcagctc accgaggacg gggactcgtt cctgcacttg gccatcatcc      360

atgaagaaaa ggcactgacc atggaagtga tccgccaggt gaagggagac ctggccttcc      420

tcaacttcca gaacaacctg cagcagactc cactccactt ggctgtgatc accaaccagc      480

cagaaattgc tgaggcactt ctgggagctg gctgtgatcc tgagctccga gactttcgag      540

gaaatacccc cctacacctt gcctgtgagc agggctgcct ggccagcgtg ggagtcctga      600

ctcagtcctg caccaccccg cacctccact ccatcctgaa ggctaccaac tacaatggcc      660

acacgtgtct acacttagcc tctatccatg gctacctggg catcgtggag cttttggtgt      720

ccttgggtgc tgatgtcaat gctcaggagc cctgtaatgg ccggactgcc cttcacctcg      780

cagtggacct gcaaaatcct gacctggtgt cactcctgtt gaagtgtggg gctgatgtca      840

acagagttac ctaccagggc tattctccct accagctcac ctggggccgc ccaagcaccc      900

ggatacagca gcagctgggc cagctgacac tagaaaacct tcagatgctg ccagagagtg      960

aggatgagga gagctatgac acagagtcag agttcacgga gttcacagag gacgagctgc     1020

cctatgatga ctgtgtgttt ggaggccagc gtctgacgtt atgagcgcaa aggggctgaa     1080

agaacatgga cttgtatatt tgtacaaaaa aaaagtttta tttttctaaa aaaagaaaaa     1140

agaagaaaaa atttaaaggg tgtacttata tccacactgc acactgcctg gcccaaaacg     1200

tcttattgtg gtaggatcag ccctcatttt gttgcttttg tgaacttttt gtaggggacg     1260

agaaagatca ttgaaattct gagaaaactt cttttaaacc tcacctttgt ggggtttttg     1320

gagaaggtta tcaaaaattt catggaagga ccacatttta tatttattgt gcttcgagtg     1380

actgacccca gtggtatcct gtgacatgta acagccagga gtgttaagcg ttcagtgatg     1440

tggggtgaaa agttactacc tgtcaaggtt tgtgttaccc tcctgtaaat ggtgtacata     1500

atgtattgtt ggtaattatt ttggtacttt tatgatgtat atttattaaa cagattttta     1560

caaatgaaaa aaaaaaaaa                                                  1579


<210> 50
<211> 317
<212> PRT
<213> Homo sapiens

<400> 50
Met Phe Gln Ala Ala Glu Arg Pro Gln Glu Trp Ala Met Glu Gly Pro 
1               5                   10                  15      


Arg Asp Gly Leu Lys Lys Glu Arg Leu Leu Asp Asp Arg His Asp Ser 
            20                  25                  30          


Gly Leu Asp Ser Met Lys Asp Glu Glu Tyr Glu Gln Met Val Lys Glu 
        35                  40                  45              


Leu Gln Glu Ile Arg Leu Glu Pro Gln Glu Val Pro Arg Gly Ser Glu 
    50                  55                  60                  


Pro Trp Lys Gln Gln Leu Thr Glu Asp Gly Asp Ser Phe Leu His Leu 
65                  70                  75                  80  


Ala Ile Ile His Glu Glu Lys Ala Leu Thr Met Glu Val Ile Arg Gln 
                85                  90                  95      


Val Lys Gly Asp Leu Ala Phe Leu Asn Phe Gln Asn Asn Leu Gln Gln 
            100                 105                 110         


Thr Pro Leu His Leu Ala Val Ile Thr Asn Gln Pro Glu Ile Ala Glu 
        115                 120                 125             


Ala Leu Leu Gly Ala Gly Cys Asp Pro Glu Leu Arg Asp Phe Arg Gly 
    130                 135                 140                 


Asn Thr Pro Leu His Leu Ala Cys Glu Gln Gly Cys Leu Ala Ser Val 
145                 150                 155                 160 


Gly Val Leu Thr Gln Ser Cys Thr Thr Pro His Leu His Ser Ile Leu 
                165                 170                 175     


Lys Ala Thr Asn Tyr Asn Gly His Thr Cys Leu His Leu Ala Ser Ile 
            180                 185                 190         


His Gly Tyr Leu Gly Ile Val Glu Leu Leu Val Ser Leu Gly Ala Asp 
        195                 200                 205             


Val Asn Ala Gln Glu Pro Cys Asn Gly Arg Thr Ala Leu His Leu Ala 
    210                 215                 220                 


Val Asp Leu Gln Asn Pro Asp Leu Val Ser Leu Leu Leu Lys Cys Gly 
225                 230                 235                 240 


Ala Asp Val Asn Arg Val Thr Tyr Gln Gly Tyr Ser Pro Tyr Gln Leu 
                245                 250                 255     


Thr Trp Gly Arg Pro Ser Thr Arg Ile Gln Gln Gln Leu Gly Gln Leu 
            260                 265                 270         


Thr Leu Glu Asn Leu Gln Met Leu Pro Glu Ser Glu Asp Glu Glu Ser 
        275                 280                 285             


Tyr Asp Thr Glu Ser Glu Phe Thr Glu Phe Thr Glu Asp Glu Leu Pro 
    290                 295                 300                 


Tyr Asp Asp Cys Val Phe Gly Gly Gln Arg Leu Thr Leu 
305                 310                 315         


<210> 51
<211> 4093
<212> DNA
<213> Homo sapiens

<400> 51
gtgagagagt gagcgagaca gaaagagaga gaagtgcacc agcgagccgg ggcaggaaga       60

ggaggtttcg ccaccggagc ggcccggcga cgcgctgaca gcttcccctg cccttcccgt      120

cggtcgggcc gccagccgcc gcagccctcg gcctgcacgc agccaccggc cccgctcccg      180

gagcccagcg ccgccgaggc cgcagccgcc cggccagtaa ggcggcgccg ccgcccggcc      240

accgcgcgcc ctgcgcttcc ctccgcccgc gctgcggcca tggcgcggcg ctgactggcc      300

tggcccggcc ccgccgcgct cccgctcgcc ccgacccgca ctcgggcccg cccgggctcc      360

ggcctgccgc cgcctcttcc ttctccagcc ggcaggcccg cgccgcttag gagggagagc      420

ccacccgcgc caggaggccg aacgcggact cgccacccgg cttcagaatg gcagaagatg      480

atccatattt gggaaggcct gaacaaatgt ttcatttgga tccttctttg actcatacaa      540

tatttaatcc agaagtattt caaccacaga tggcactgcc aacagcagat ggcccatacc      600

ttcaaatatt agagcaacct aaacagagag gatttcgttt ccgttatgta tgtgaaggcc      660

catcccatgg tggactacct ggtgcctcta gtgaaaagaa caagaagtct taccctcagg      720

tcaaaatctg caactatgtg ggaccagcaa aggttattgt tcagttggtc acaaatggaa      780

aaaatatcca cctgcatgcc cacagcctgg tgggaaaaca ctgtgaggat gggatctgca      840

ctgtaactgc tggacccaag gacatggtgg tcggcttcgc aaacctgggt atacttcatg      900

tgacaaagaa aaaagtattt gaaacactgg aagcacgaat gacagaggcg tgtataaggg      960

gctataatcc tggactcttg gtgcaccctg accttgccta tttgcaagca gaaggtggag     1020

gggaccggca gctgggagat cgggaaaaag agctaatccg ccaagcagct ctgcagcaga     1080

ccaaggagat ggacctcagc gtggtgcggc tcatgtttac agcttttctt ccggatagca     1140

ctggcagctt cacaaggcgc ctggaacccg tggtatcaga cgccatctat gacagtaaag     1200

cccccaatgc atccaacttg aaaattgtaa gaatggacag gacagctgga tgtgtgactg     1260

gaggggagga aatttatctt ctttgtgaca aagttcagaa agatgacatc cagattcgat     1320

tttatgaaga ggaagaaaat ggtggagtct gggaaggatt tggagatttt tcccccacag     1380

atgttcatag acaatttgcc attgtcttca aaactccaaa gtataaagat attaatatta     1440

caaaaccagc ctctgtgttt gtccagcttc ggaggaaatc tgacttggaa actagtgaac     1500

caaaaccttt cctctactat cctgaaatca aagataaaga agaagtgcag aggaaacgtc     1560

agaagctcat gcccaatttt tcggatagtt tcggcggtgg tagtggtgct ggagctggag     1620

gcggaggcat gtttggtagt ggcggtggag gagggggcac tggaagtaca ggtccagggt     1680

atagcttccc acactatgga tttcctactt atggtgggat tactttccat cctggaacta     1740

ctaaatctaa tgctgggatg aagcatggaa ccatggacac tgaatctaaa aaggaccctg     1800

aaggttgtga caaaagtgat gacaaaaaca ctgtaaacct ctttgggaaa gttattgaaa     1860

ccacagagca agatcaggag cccagcgagg ccaccgttgg gaatggtgag gtcactctaa     1920

cgtatgcaac aggaacaaaa gaagagagtg ctggagttca ggataacctc tttctagaga     1980

aggctatgca gcttgcaaag aggcatgcca atgccctttt cgactacgcg gtgacaggag     2040

acgtgaagat gctgctggcc gtccagcgcc atctcactgc tgtgcaggat gagaatgggg     2100

acagtgtctt acacttagca atcatccacc ttcattctca acttgtgagg gatctactag     2160

aagtcacatc tggtttgatt tctgatgaca ttatcaacat gagaaatgat ctgtaccaga     2220

cgcccttgca cttggcagtg atcactaagc aggaagatgt ggtggaggat ttgctgaggg     2280

ctggggccga cctgagcctt ctggaccgct tgggtaactc tgttttgcac ctagctgcca     2340

aagaaggaca tgataaagtt ctcagtatct tactcaagca caaaaaggca gcactacttc     2400

ttgaccaccc caacggggac ggtctgaatg ccattcatct agccatgatg agcaatagcc     2460

tgccatgttt gctgctgctg gtggccgctg gggctgacgt caatgctcag gagcagaagt     2520

ccgggcgcac agcactgcac ctggctgtgg agcacgacaa catctcattg gcaggctgcc     2580

tgctcctgga gggtgatgcc catgtggaca gtactaccta cgatggaacc acacccctgc     2640

atatagcagc tgggagaggg tccaccaggc tggcagctct tctcaaagca gcaggagcag     2700

atcccctggt ggagaacttt gagcctctct atgacctgga tgactcttgg gaaaatgcag     2760

gagaggatga aggagttgtg cctggaacca cgcctctaga tatggccacc agctggcagg     2820

tatttgacat attaaatggg aaaccatatg agccagagtt tacatctgat gatttactag     2880

cacaaggaga catgaaacag ctggctgaag atgtgaagct gcagctgtat aagttactag     2940

aaattcctga tccagacaaa aactgggcta ctctggcgca gaaattaggt ctggggatac     3000

ttaataatgc cttccggctg agtcctgctc cttccaaaac acttatggac aactatgagg     3060

tctctggggg tacagtcaga gagctggtgg aggccctgag acaaatgggc tacaccgaag     3120

caattgaagt gatccaggca gcctccagcc cagtgaagac cacctctcag gcccactcgc     3180

tgcctctctc gcctgcctcc acaaggcagc aaatagacga gctccgagac agtgacagtg     3240

tctgcgacag cggcgtggag acatccttcc gcaaactcag ctttaccgag tctctgacca     3300

gtggtgcctc actgctaact ctcaacaaaa tgccccatga ttatgggcag gaaggacctc     3360

tagaaggcaa aatttagcct gctgacaatt tcccacaccg tgtaaaccaa agccctaaaa     3420

ttccactgcg ttgtccacaa gacagaagct gaagtgcatc caaaggtgct cagagagccg     3480

gcccgcctga atcattctcg atttaactcg agaccttttc aacttggctt cctttcttgg     3540

ttcataaatg aattttagtt tggttcactt acagatagta tctagcaatc acaacactgg     3600

ctgagcggat gcatctgggg atgaggttgc ttactaagct ttgccagctg ctgctggatc     3660

acagctgctt tctgttgtca ttgctgttgt ccctctgcta cgttcctatt gtcattaaag     3720

gtatcacggt cgccacctgg cattccttct gaccacagca tcattttgca ttcaaattaa     3780

gggttaagaa aagagatatt ttaaaatgag agtcacttga tgtgccattt taaaaaaaaa     3840

ggcatattgc tttttctaat gtggttattt ctctgatttg caaaaaaaaa aaaaaaaaaa     3900

atacttgtca atatttaaac atggttacaa tcattgctga aaatggtatt ttcccccttt     3960

tctgcatttt gctattgtaa atatgttttt tagatcaaat actttaaagg aaaaaatgtt     4020

ggatttataa atgctatttt ttattttact tttataataa aaggaaaagc aaattgatga     4080

cctcaaaaaa aaa                                                        4093


<210> 52
<211> 969
<212> PRT
<213> Homo sapiens

<400> 52
Met Ala Glu Asp Asp Pro Tyr Leu Gly Arg Pro Glu Gln Met Phe His 
1               5                   10                  15      


Leu Asp Pro Ser Leu Thr His Thr Ile Phe Asn Pro Glu Val Phe Gln 
            20                  25                  30          


Pro Gln Met Ala Leu Pro Thr Ala Asp Gly Pro Tyr Leu Gln Ile Leu 
        35                  40                  45              


Glu Gln Pro Lys Gln Arg Gly Phe Arg Phe Arg Tyr Val Cys Glu Gly 
    50                  55                  60                  


Pro Ser His Gly Gly Leu Pro Gly Ala Ser Ser Glu Lys Asn Lys Lys 
65                  70                  75                  80  


Ser Tyr Pro Gln Val Lys Ile Cys Asn Tyr Val Gly Pro Ala Lys Val 
                85                  90                  95      


Ile Val Gln Leu Val Thr Asn Gly Lys Asn Ile His Leu His Ala His 
            100                 105                 110         


Ser Leu Val Gly Lys His Cys Glu Asp Gly Ile Cys Thr Val Thr Ala 
        115                 120                 125             


Gly Pro Lys Asp Met Val Val Gly Phe Ala Asn Leu Gly Ile Leu His 
    130                 135                 140                 


Val Thr Lys Lys Lys Val Phe Glu Thr Leu Glu Ala Arg Met Thr Glu 
145                 150                 155                 160 


Ala Cys Ile Arg Gly Tyr Asn Pro Gly Leu Leu Val His Pro Asp Leu 
                165                 170                 175     


Ala Tyr Leu Gln Ala Glu Gly Gly Gly Asp Arg Gln Leu Gly Asp Arg 
            180                 185                 190         


Glu Lys Glu Leu Ile Arg Gln Ala Ala Leu Gln Gln Thr Lys Glu Met 
        195                 200                 205             


Asp Leu Ser Val Val Arg Leu Met Phe Thr Ala Phe Leu Pro Asp Ser 
    210                 215                 220                 


Thr Gly Ser Phe Thr Arg Arg Leu Glu Pro Val Val Ser Asp Ala Ile 
225                 230                 235                 240 


Tyr Asp Ser Lys Ala Pro Asn Ala Ser Asn Leu Lys Ile Val Arg Met 
                245                 250                 255     


Asp Arg Thr Ala Gly Cys Val Thr Gly Gly Glu Glu Ile Tyr Leu Leu 
            260                 265                 270         


Cys Asp Lys Val Gln Lys Asp Asp Ile Gln Ile Arg Phe Tyr Glu Glu 
        275                 280                 285             


Glu Glu Asn Gly Gly Val Trp Glu Gly Phe Gly Asp Phe Ser Pro Thr 
    290                 295                 300                 


Asp Val His Arg Gln Phe Ala Ile Val Phe Lys Thr Pro Lys Tyr Lys 
305                 310                 315                 320 


Asp Ile Asn Ile Thr Lys Pro Ala Ser Val Phe Val Gln Leu Arg Arg 
                325                 330                 335     


Lys Ser Asp Leu Glu Thr Ser Glu Pro Lys Pro Phe Leu Tyr Tyr Pro 
            340                 345                 350         


Glu Ile Lys Asp Lys Glu Glu Val Gln Arg Lys Arg Gln Lys Leu Met 
        355                 360                 365             


Pro Asn Phe Ser Asp Ser Phe Gly Gly Gly Ser Gly Ala Gly Ala Gly 
    370                 375                 380                 


Gly Gly Gly Met Phe Gly Ser Gly Gly Gly Gly Gly Gly Thr Gly Ser 
385                 390                 395                 400 


Thr Gly Pro Gly Tyr Ser Phe Pro His Tyr Gly Phe Pro Thr Tyr Gly 
                405                 410                 415     


Gly Ile Thr Phe His Pro Gly Thr Thr Lys Ser Asn Ala Gly Met Lys 
            420                 425                 430         


His Gly Thr Met Asp Thr Glu Ser Lys Lys Asp Pro Glu Gly Cys Asp 
        435                 440                 445             


Lys Ser Asp Asp Lys Asn Thr Val Asn Leu Phe Gly Lys Val Ile Glu 
    450                 455                 460                 


Thr Thr Glu Gln Asp Gln Glu Pro Ser Glu Ala Thr Val Gly Asn Gly 
465                 470                 475                 480 


Glu Val Thr Leu Thr Tyr Ala Thr Gly Thr Lys Glu Glu Ser Ala Gly 
                485                 490                 495     


Val Gln Asp Asn Leu Phe Leu Glu Lys Ala Met Gln Leu Ala Lys Arg 
            500                 505                 510         


His Ala Asn Ala Leu Phe Asp Tyr Ala Val Thr Gly Asp Val Lys Met 
        515                 520                 525             


Leu Leu Ala Val Gln Arg His Leu Thr Ala Val Gln Asp Glu Asn Gly 
    530                 535                 540                 


Asp Ser Val Leu His Leu Ala Ile Ile His Leu His Ser Gln Leu Val 
545                 550                 555                 560 


Arg Asp Leu Leu Glu Val Thr Ser Gly Leu Ile Ser Asp Asp Ile Ile 
                565                 570                 575     


Asn Met Arg Asn Asp Leu Tyr Gln Thr Pro Leu His Leu Ala Val Ile 
            580                 585                 590         


Thr Lys Gln Glu Asp Val Val Glu Asp Leu Leu Arg Ala Gly Ala Asp 
        595                 600                 605             


Leu Ser Leu Leu Asp Arg Leu Gly Asn Ser Val Leu His Leu Ala Ala 
    610                 615                 620                 


Lys Glu Gly His Asp Lys Val Leu Ser Ile Leu Leu Lys His Lys Lys 
625                 630                 635                 640 


Ala Ala Leu Leu Leu Asp His Pro Asn Gly Asp Gly Leu Asn Ala Ile 
                645                 650                 655     


His Leu Ala Met Met Ser Asn Ser Leu Pro Cys Leu Leu Leu Leu Val 
            660                 665                 670         


Ala Ala Gly Ala Asp Val Asn Ala Gln Glu Gln Lys Ser Gly Arg Thr 
        675                 680                 685             


Ala Leu His Leu Ala Val Glu His Asp Asn Ile Ser Leu Ala Gly Cys 
    690                 695                 700                 


Leu Leu Leu Glu Gly Asp Ala His Val Asp Ser Thr Thr Tyr Asp Gly 
705                 710                 715                 720 


Thr Thr Pro Leu His Ile Ala Ala Gly Arg Gly Ser Thr Arg Leu Ala 
                725                 730                 735     


Ala Leu Leu Lys Ala Ala Gly Ala Asp Pro Leu Val Glu Asn Phe Glu 
            740                 745                 750         


Pro Leu Tyr Asp Leu Asp Asp Ser Trp Glu Asn Ala Gly Glu Asp Glu 
        755                 760                 765             


Gly Val Val Pro Gly Thr Thr Pro Leu Asp Met Ala Thr Ser Trp Gln 
    770                 775                 780                 


Val Phe Asp Ile Leu Asn Gly Lys Pro Tyr Glu Pro Glu Phe Thr Ser 
785                 790                 795                 800 


Asp Asp Leu Leu Ala Gln Gly Asp Met Lys Gln Leu Ala Glu Asp Val 
                805                 810                 815     


Lys Leu Gln Leu Tyr Lys Leu Leu Glu Ile Pro Asp Pro Asp Lys Asn 
            820                 825                 830         


Trp Ala Thr Leu Ala Gln Lys Leu Gly Leu Gly Ile Leu Asn Asn Ala 
        835                 840                 845             


Phe Arg Leu Ser Pro Ala Pro Ser Lys Thr Leu Met Asp Asn Tyr Glu 
    850                 855                 860                 


Val Ser Gly Gly Thr Val Arg Glu Leu Val Glu Ala Leu Arg Gln Met 
865                 870                 875                 880 


Gly Tyr Thr Glu Ala Ile Glu Val Ile Gln Ala Ala Ser Ser Pro Val 
                885                 890                 895     


Lys Thr Thr Ser Gln Ala His Ser Leu Pro Leu Ser Pro Ala Ser Thr 
            900                 905                 910         


Arg Gln Gln Ile Asp Glu Leu Arg Asp Ser Asp Ser Val Cys Asp Ser 
        915                 920                 925             


Gly Val Glu Thr Ser Phe Arg Lys Leu Ser Phe Thr Glu Ser Leu Thr 
    930                 935                 940                 


Ser Gly Ala Ser Leu Leu Thr Leu Asn Lys Met Pro His Asp Tyr Gly 
945                 950                 955                 960 


Gln Glu Gly Pro Leu Glu Gly Lys Ile 
                965                 


<210> 53
<211> 1777
<212> DNA
<213> Homo sapiens

<400> 53
ctgatggtat ctctgtttca ggagtggtga cgcctaagct atcactggac atatcaagga       60

cttcactaaa ttagcaggta ccactggtct tcttgtgctt atccgggcaa gaacttatcg      120

aaatacaata gaagttttta cttagaagag attttcagct gctgtggatt ggattatgcc      180

atttggaata agaatgctgt taagagcaca caagccaggg agaagtgaaa tgacaacctc      240

actagataca gttgagacct ttggtaccac atcctactat gatgacgtgg gcctgctctg      300

tgaaaaagct gataccagag cactgatggc ccagtttgtg cccccgctgt actccctggt      360

gttcactgtg ggcctcttgg gcaatgtggt ggtggtgatg atcctcataa aatacaggag      420

gctccgaatt atgaccaaca tctacctgct caacctggcc atttcggacc tgctcttcct      480

cgtcaccctt ccattctgga tccactatgt cagggggcat aactgggttt ttggccatgg      540

catgtgtaag ctcctctcag ggttttatca cacaggcttg tacagcgaga tctttttcat      600

aatcctgctg acaatcgaca ggtacctggc cattgtccat gctgtgtttg cccttcgagc      660

ccggactgtc acttttggtg tcatcaccag catcgtcacc tggggcctgg cagtgctagc      720

agctcttcct gaatttatct tctatgagac tgaagagttg tttgaagaga ctctttgcag      780

tgctctttac ccagaggata cagtatatag ctggaggcat ttccacactc tgagaatgac      840

catcttctgt ctcgttctcc ctctgctcgt tatggccatc tgctacacag gaatcatcaa      900

aacgctgctg aggtgcccca gtaaaaaaaa gtacaaggcc atccggctca tttttgtcat      960

catggcggtg tttttcattt tctggacacc ctacaatgtg gctatccttc tctcttccta     1020

tcaatccatc ttatttggaa atgactgtga gcggagcaag catctggacc tggtcatgct     1080

ggtgacagag gtgatcgcct actcccactg ctgcatgaac ccggtgatct acgcctttgt     1140

tggagagagg ttccggaagt acctgcgcca cttcttccac aggcacttgc tcatgcacct     1200

gggcagatac atcccattcc ttcctagtga gaagctggaa agaaccagct ctgtctctcc     1260

atccacagca gagccggaac tctctattgt gttttaggtc agatgcagaa aattgcctaa     1320

agaggaagga ccaaggagat gaagcaaaca cattaagcct tccacactca cctctaaaac     1380

agtccttcaa acttccagtg caacactgaa gctcttgaag acactgaaat atacacacag     1440

cagtagcagt agatgcatgt accctaaggt cattaccaca ggccaggggc tgggcagcgt     1500

actcatcatc aaccctaaaa agcagagctt tgcttctctc tctaaaatga gttacctaca     1560

ttttaatgca cctgaatgtt agatagttac tatatgccgc tacaaaaagg taaaactttt     1620

tatattttat acattaactt cagccagcta ttgatataaa taaaacattt tcacacaata     1680

caataagtta actattttat tttctaatgt gcctagttct ttccctgctt aatgaaaagc     1740

ttgttttttc agtgtgaata aataatcgta agcaaca                              1777


<210> 54
<211> 373
<212> PRT
<213> Homo sapiens

<400> 54
Met Pro Phe Gly Ile Arg Met Leu Leu Arg Ala His Lys Pro Gly Arg 
1               5                   10                  15      


Ser Glu Met Thr Thr Ser Leu Asp Thr Val Glu Thr Phe Gly Thr Thr 
            20                  25                  30          


Ser Tyr Tyr Asp Asp Val Gly Leu Leu Cys Glu Lys Ala Asp Thr Arg 
        35                  40                  45              


Ala Leu Met Ala Gln Phe Val Pro Pro Leu Tyr Ser Leu Val Phe Thr 
    50                  55                  60                  


Val Gly Leu Leu Gly Asn Val Val Val Val Met Ile Leu Ile Lys Tyr 
65                  70                  75                  80  


Arg Arg Leu Arg Ile Met Thr Asn Ile Tyr Leu Leu Asn Leu Ala Ile 
                85                  90                  95      


Ser Asp Leu Leu Phe Leu Val Thr Leu Pro Phe Trp Ile His Tyr Val 
            100                 105                 110         


Arg Gly His Asn Trp Val Phe Gly His Gly Met Cys Lys Leu Leu Ser 
        115                 120                 125             


Gly Phe Tyr His Thr Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu 
    130                 135                 140                 


Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu 
145                 150                 155                 160 


Arg Ala Arg Thr Val Thr Phe Gly Val Ile Thr Ser Ile Val Thr Trp 
                165                 170                 175     


Gly Leu Ala Val Leu Ala Ala Leu Pro Glu Phe Ile Phe Tyr Glu Thr 
            180                 185                 190         


Glu Glu Leu Phe Glu Glu Thr Leu Cys Ser Ala Leu Tyr Pro Glu Asp 
        195                 200                 205             


Thr Val Tyr Ser Trp Arg His Phe His Thr Leu Arg Met Thr Ile Phe 
    210                 215                 220                 


Cys Leu Val Leu Pro Leu Leu Val Met Ala Ile Cys Tyr Thr Gly Ile 
225                 230                 235                 240 


Ile Lys Thr Leu Leu Arg Cys Pro Ser Lys Lys Lys Tyr Lys Ala Ile 
                245                 250                 255     


Arg Leu Ile Phe Val Ile Met Ala Val Phe Phe Ile Phe Trp Thr Pro 
            260                 265                 270         


Tyr Asn Val Ala Ile Leu Leu Ser Ser Tyr Gln Ser Ile Leu Phe Gly 
        275                 280                 285             


Asn Asp Cys Glu Arg Ser Lys His Leu Asp Leu Val Met Leu Val Thr 
    290                 295                 300                 


Glu Val Ile Ala Tyr Ser His Cys Cys Met Asn Pro Val Ile Tyr Ala 
305                 310                 315                 320 


Phe Val Gly Glu Arg Phe Arg Lys Tyr Leu Arg His Phe Phe His Arg 
                325                 330                 335     


His Leu Leu Met His Leu Gly Arg Tyr Ile Pro Phe Leu Pro Ser Glu 
            340                 345                 350         


Lys Leu Glu Arg Thr Ser Ser Val Ser Pro Ser Thr Ala Glu Pro Glu 
        355                 360                 365             


Leu Ser Ile Val Phe 
    370             


<210> 55
<211> 3960
<212> DNA
<213> Homo sapiens

<400> 55
gtttttctct gcttggtgag cagagataaa gggggcagca ggaccgggcc caccagccat       60

ccgggctgcc cacgcaaacc acagggccga atccggagcc gcccaaggcc acacagctaa      120

gccgagtgcg tgaatgctta tgtgaccgtg tgaaggaggt tcccaccgtg tggctgtggg      180

ggatggaaaa aggctacttg gaaagatgta gaagaccttc gagtaaacag ttacgtttca      240

gaaacagagc ctgctcagaa tgtgtacttg gtgggattct attcttaggg acgcttcttt      300

cttctgagag acccgagctc tgtggcgagt ggcacaggca gggccccttc ctttcctagt      360

tgggttctga cagctccgag gcagtggttt acacaaccaa cacgaaacat ttctacgatc      420

cacccgattc ctcccctcat tgatattcag gaagcagctc tccttcccct gccttcagct      480

caagtttgct gagcttttgt ttcatttgtg aatacttctt gctggaagtc cctcacccag      540

agaccagtgc tcccaacggc agagcagcgg gggagataaa gaactggtga cacgtggctg      600

tacattcagc acagctgtgg tgtccccaag tgccatgacc caggagccat tcagagagga      660

gctggcctat gaccggatgc ccacgctgga gcggggccgg caagaccccg ccagctatgc      720

cccagacgcg aagccgagcg acctgcagct gtcgaagaga ctgcccccct gcttcagcca      780

caagacgtgg gtcttctctg tgctgatggg gagctgcctc ctggtgacct cggggttttc      840

gctgtacctg gggaacgtgt tcccggctga gatggattac ttgcgctgtg ctgcaggctc      900

ttgcatcccc tcggcaattg tgagcttcac cgtctccagg aggaacgcca atgtgattcc      960

caactttcag atattgtttg tttccacgtt tgctgtgacc actacgtgtt taatttggtt     1020

tggatgcaaa ctagtcctga acccatcagc aataaacatc aacttcaacc tcatcctgct     1080

gctcctgctg gagctgctca tggcggccac ggtgatcatc gctgcacggt ccagcgagga     1140

ggactgcaag aaaaagaagg gctccatgtc tgacagcgcc aacattctgg acgaagtgcc     1200

atttcctgct cgggtcctga aatcttactc agtcgtcgag gtaatcgcag gcatctctgc     1260

cgtcctcggg gggatcattg ccctgaacgt ggatgactca gtttcaggcc cacacctctc     1320

agtgacgttc ttttggatcc tagtggcctg ctttccaagt gccattgcca gtcatgtggc     1380

agcagagtgt cccagcaagt gtctggtgga ggtcctgatt gccataagca gcctcacgtc     1440

tccgctgctg ttcacagcct ctggatatct gtcattcagc atcatgagaa tcgtggagat     1500

gtttaaggat tacccgccag ccataaaacc atcctacgat gtgctgctgc tgctgctgct     1560

gctagtgctc ctgctgcagg ccggcctcaa cacgggcacc gccatccagt gcgtgcgctt     1620

caaggtcagt gcaaggctgc agggtgcatc ctgggacacc cagaacggcc cgcaggagcg     1680

cctggctggg gaggtggcca ggagccccct gaaggagttc gacaaggaga aagcctggag     1740

agccgtcgtg gtgcaaatgg cccagtgacc cccagacgcg gaaaccgggt ggcagcgccc     1800

agcctggccc caagcatgga aacgcacaac ccctaatcgc cctgagctac tgcttctaac     1860

acctcttttc ccttgtgtga gggcaaacca ggctgcaggt ggggttttca cttcctaggg     1920

tagtttaatt ttaaaatagg ccaatgttgg ctagtctgtg cctcagtgag atcagtcagc     1980

tccgagtggc tcccgtgtcg taacagcagg agcatggccg caacttccca ggccgaggaa     2040

gggcccccgg ctcggcctct tgagagcccc acccctgaac tggccccagc tcctcttcct     2100

gcctctctca tggcttgggc tggagtgggc tctctggacc tgaccagact gtgggtccct     2160

gcgtctcctg cccactctga ccgggcttcc tccctccacg cttagggtct gtcccgggta     2220

ctcagtcagc ccagtgggat cttacccact tccctgcaag gtgcacctgc cccaggctca     2280

ggctgcccag cggctcttcc tggacagtga gagcagggct gggcgcctct gtcctggccc     2340

gggagccgca ggggcccctc ctccagagcc tgggcgcaag cgacacaggc tgccgctgct     2400

ctcccaggtg aaatccacac cagtccacgc cgggtcgcct gccctgtctc cctacttaga     2460

cccagtcatt ctagagggat ccaccgccac actggccggc ccacgtcctg ggtgctgtca     2520

tgcccagctt ggagtgccac gtggccgctg cccacgtccc gggcactgtc atgcccagct     2580

tggagtgcca catggccgct gcccacgtcc cgggcactgt catgcccagc ttggagtgcc     2640

acgtggccgc tgctgtgaca ggcagtgttc ttgggggtgg ggctgcatcc aaggctttgt     2700

aaaccggctg gaccacgtct ccctggcccc agtgaccggg ggaagctgag cccctccctc     2760

ctgtgtttgc tcccattact caaaatgcag gacagatcag gtcagagccc aggaattctc     2820

acaggttcac ccagcgccct ctacctccta gcaagtactt tgtcttgatc ctcactgaga     2880

aggccccagg gcagcggtct tctccatctc cgctgttttg gggtcttagg gtacagccca     2940

ggcggtcact gcccacctgc caggctgcag ggacagttgg gtgtgagaat aacactggct     3000

ttgggtagtg ccatggccag gagtgggttt ccctgcgtct cctcgtcccg agggcgcctg     3060

ggtcctccca gctgacggca gtaaatccac agtgagttgg ggcgactgtg aaactggaat     3120

gctgttactt tgataattac tttccagcag gtgttttcct tcacaatggt tttgtttctt     3180

tccttctgat ctgagaagac atgaacgttt tctcttcacc gccgtggggt gtattgactg     3240

gtcccccatg ggctgctgga aaggcccgga gatgcatctg tggcctgggg ccatcaagat     3300

caaagaacca ggaggcctgg gagatgcagc tggatggggc ggcctgcaga ccctgccagg     3360

gggtttgagg accctcccag gtttcccact gcggaacagg agtgactctg gctgccaaga     3420

taccttcatg gtgttcatga caagtggaat cattattttc aaccattgaa gggggatgca     3480

ggcaagacac cttcccagct gctcctagag gggacaagcc aggccctctc tgcagtcctc     3540

ggcagctccg gaaggacaca gtcaggggcc gggcaaacac tttggccaca gccccaaaca     3600

agcgccaccg tgggagagga gaggctgctg tcactggtac cggatgcaga ccccaccctg     3660

tctgcaggcc acccccacct ccctgcagct ttgaggctgg cggggtctgc tcctgggaat     3720

ggggtgggag ccacagggac gacccggggc gggctgatgt cttcttgggg gcagaccaga     3780

gagctcaagt ttcagagtca gaattaggca cttggagcgt ttttgctggc ttgcactttc     3840

ttattttctt attttagagc gcttaaaaaa tccggaaaaa tggggtttaa aagaactgtc     3900

tctttcagtc tacatttttg tttaatacgc ttgagcaata aacgctgact tgcagacgtg     3960


<210> 56
<211> 377
<212> PRT
<213> Homo sapiens

<400> 56
Met Thr Gln Glu Pro Phe Arg Glu Glu Leu Ala Tyr Asp Arg Met Pro 
1               5                   10                  15      


Thr Leu Glu Arg Gly Arg Gln Asp Pro Ala Ser Tyr Ala Pro Asp Ala 
            20                  25                  30          


Lys Pro Ser Asp Leu Gln Leu Ser Lys Arg Leu Pro Pro Cys Phe Ser 
        35                  40                  45              


His Lys Thr Trp Val Phe Ser Val Leu Met Gly Ser Cys Leu Leu Val 
    50                  55                  60                  


Thr Ser Gly Phe Ser Leu Tyr Leu Gly Asn Val Phe Pro Ala Glu Met 
65                  70                  75                  80  


Asp Tyr Leu Arg Cys Ala Ala Gly Ser Cys Ile Pro Ser Ala Ile Val 
                85                  90                  95      


Ser Phe Thr Val Ser Arg Arg Asn Ala Asn Val Ile Pro Asn Phe Gln 
            100                 105                 110         


Ile Leu Phe Val Ser Thr Phe Ala Val Thr Thr Thr Cys Leu Ile Trp 
        115                 120                 125             


Phe Gly Cys Lys Leu Val Leu Asn Pro Ser Ala Ile Asn Ile Asn Phe 
    130                 135                 140                 


Asn Leu Ile Leu Leu Leu Leu Leu Glu Leu Leu Met Ala Ala Thr Val 
145                 150                 155                 160 


Ile Ile Ala Ala Arg Ser Ser Glu Glu Asp Cys Lys Lys Lys Lys Gly 
                165                 170                 175     


Ser Met Ser Asp Ser Ala Asn Ile Leu Asp Glu Val Pro Phe Pro Ala 
            180                 185                 190         


Arg Val Leu Lys Ser Tyr Ser Val Val Glu Val Ile Ala Gly Ile Ser 
        195                 200                 205             


Ala Val Leu Gly Gly Ile Ile Ala Leu Asn Val Asp Asp Ser Val Ser 
    210                 215                 220                 


Gly Pro His Leu Ser Val Thr Phe Phe Trp Ile Leu Val Ala Cys Phe 
225                 230                 235                 240 


Pro Ser Ala Ile Ala Ser His Val Ala Ala Glu Cys Pro Ser Lys Cys 
                245                 250                 255     


Leu Val Glu Val Leu Ile Ala Ile Ser Ser Leu Thr Ser Pro Leu Leu 
            260                 265                 270         


Phe Thr Ala Ser Gly Tyr Leu Ser Phe Ser Ile Met Arg Ile Val Glu 
        275                 280                 285             


Met Phe Lys Asp Tyr Pro Pro Ala Ile Lys Pro Ser Tyr Asp Val Leu 
    290                 295                 300                 


Leu Leu Leu Leu Leu Leu Val Leu Leu Leu Gln Ala Gly Leu Asn Thr 
305                 310                 315                 320 


Gly Thr Ala Ile Gln Cys Val Arg Phe Lys Val Ser Ala Arg Leu Gln 
                325                 330                 335     


Gly Ala Ser Trp Asp Thr Gln Asn Gly Pro Gln Glu Arg Leu Ala Gly 
            340                 345                 350         


Glu Val Ala Arg Ser Pro Leu Lys Glu Phe Asp Lys Glu Lys Ala Trp 
        355                 360                 365             


Arg Ala Val Val Val Gln Met Ala Gln 
    370                 375         


<210> 57
<211> 1926
<212> DNA
<213> Homo sapiens

<400> 57
gtggatgagc tgtgagtgcg cgcgcgtgcg cggggccgcg acctgtgccg gctcgagccc       60

gctgggcact cggaggcgcg cacgtcgttc cccgccctcc cgccgccgcc cgccctcgct      120

ctctcgcgct accctcccgc cgcccgcggt cctccgtcgg ttctctcgtt agtccacggt      180

ctggtcttca gctacccgcc ttcgtctccg agtttgcgac tcgcggaccg gcgtccccgg      240

cgcgaagagg ctggactcgg attcgttgcc tgagcaatgg ctgccatccg gaagaaactg      300

gtgattgttg gtgatggagc ctgtggaaag acatgcttgc tcatagtctt cagcaaggac      360

cagttcccag aggtgtatgt gcccacagtg tttgagaact atgtggcaga tatcgaggtg      420

gatggaaagc aggtagagtt ggctttgtgg gacacagctg ggcaggaaga ttatgatcgc      480

ctgaggcccc tctcctaccc agataccgat gttatactga tgtgtttttc catcgacagc      540

cctgatagtt tagaaaacat cccagaaaag tggaccccag aagtcaagca tttctgtccc      600

aacgtgccca tcatcctggt tgggaataag aaggatcttc ggaatgatga gcacacaagg      660

cgggagctag ccaagatgaa gcaggagccg gtgaaacctg aagaaggcag agatatggca      720

aacaggattg gcgcttttgg gtacatggag tgttcagcaa agaccaaaga tggagtgaga      780

gaggtttttg aaatggctac gagagctgct ctgcaagcta gacgtgggaa gaaaaaatct      840

gggtgccttg tcttgtgaaa ccttgctgca agcacagccc ttatgcggtt aattttgaag      900

tgctgtttat taatcttagt gtatgattac tggccttttt catttatcta taatttacct      960

aagattacaa atcagaagtc atcttgctac cagtatttag aagccaacta tgattattaa     1020

cgatgtccaa cccgtctggc ccaccagggt ccttttgaca ctgctctaac agccctcctc     1080

tgcactccca cctgacacac caggcgctaa ttcaaggaat ttcttaactt cttgcttctt     1140

tctagaaaga gaaacagttg gtaacttttg tgaattaggc tgtaactact ttataactaa     1200

catgtcctgc ctattatctg tcagctgcaa ggtactctgg tgagtcacca cttcagggct     1260

ttactccgta acagattttg ttggcatagc tctggggtgg gcagtttttt gaaaatgggc     1320

tcaaccagaa aagcccaagt tcatgcagct gtggcagagt tacagttctg tggtttcatg     1380

ttagttacct tatagttact gtgtaattag tgccacttaa tgtatgttac caaaaataaa     1440

tatatctacc ccagactaga tgtagtattt tttgtataat tggatttcct aatactgtca     1500

tcctcaaaga aagtgtattg gttttttaaa aaagaaagtg tatttggaaa taaagtcaga     1560

tggaaaattc attttttaaa ttcccgtttt gtcacttttt ctgataaaag atggccatat     1620

tacccctttt cggccccatg tatctcagta ccccatggag ctgggctaag taaataggaa     1680

ttggtttcac gcctgaggca attagacact ttggaagatg gcataacctg tctcacctgg     1740

acttaagcat ctggctctaa ttcacagtgc tcttttctcc tcactgtatc caggttccct     1800

cccagaggag ccaccagttc tcatgggtgg cactcagtct ctcttctctc cagctgacta     1860

aacttttttt ctgtaccagt taatttttcc aactactaat agaataaagg cagttttcta     1920

aaaaaa                                                                1926


<210> 58
<211> 193
<212> PRT
<213> Homo sapiens

<400> 58
Met Ala Ala Ile Arg Lys Lys Leu Val Ile Val Gly Asp Gly Ala Cys 
1               5                   10                  15      


Gly Lys Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Gln Phe Pro Glu 
            20                  25                  30          


Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Val Ala Asp Ile Glu Val 
        35                  40                  45              


Asp Gly Lys Gln Val Glu Leu Ala Leu Trp Asp Thr Ala Gly Gln Glu 
    50                  55                  60                  


Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Asp Thr Asp Val Ile 
65                  70                  75                  80  


Leu Met Cys Phe Ser Ile Asp Ser Pro Asp Ser Leu Glu Asn Ile Pro 
                85                  90                  95      


Glu Lys Trp Thr Pro Glu Val Lys His Phe Cys Pro Asn Val Pro Ile 
            100                 105                 110         


Ile Leu Val Gly Asn Lys Lys Asp Leu Arg Asn Asp Glu His Thr Arg 
        115                 120                 125             


Arg Glu Leu Ala Lys Met Lys Gln Glu Pro Val Lys Pro Glu Glu Gly 
    130                 135                 140                 


Arg Asp Met Ala Asn Arg Ile Gly Ala Phe Gly Tyr Met Glu Cys Ser 
145                 150                 155                 160 


Ala Lys Thr Lys Asp Gly Val Arg Glu Val Phe Glu Met Ala Thr Arg 
                165                 170                 175     


Ala Ala Leu Gln Ala Arg Arg Gly Lys Lys Lys Ser Gly Cys Leu Val 
            180                 185                 190         


Leu 
    


<210> 59
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 59
cctgaaggaa ctgaaaggaa ag                                                22


<210> 60
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 60
ttggcagata tgcagggagt                                                   20


<210> 61
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 61
ccctccactg taacgaagac tc                                                22


<210> 62
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 62
cacacccagt agcagtcatc c                                                 21


<210> 63
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 63
gaacactgag ctaaaaactc tcctg                                             25


<210> 64
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 64
gagaccatgg cactgaacg                                                    19


<210> 65
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 65
gggctgtcac ggagatca                                                     18


<210> 66
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 66
ccatgatggt cacattctgc                                                   20


<210> 67
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 67
catccgtaaa gacctctatg ccaac                                             25


<210> 68
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 68
accagaggca tacagggaca                                                   20


