                         SEQUENCE LISTING

<110>  The United States of America, as represented by the 
       Secretary, Department of Health and Human Services
       Lusso, Paolo
       Cimbro, Raffaello
 
<120>  HIV THERAPEUTICS AND METHODS OF MAKING AND USING SAME

<130>  4239-88641-02

<150>  US 61/736,350
<151>  2012-12-12

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  511
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  1

Met Arg Val Lys Glu Lys Tyr Gln His Leu Trp Arg Trp Gly Trp Arg 
1               5                   10                  15      


Trp Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Thr Glu 
            20                  25                  30          


Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala 
        35                  40                  45              


Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu 
    50                  55                  60                  


Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
65                  70                  75                  80  


Pro Gln Glu Val Val Leu Val Asn Val Thr Glu Asn Phe Asn Met Trp 
                85                  90                  95      


Lys Asn Asp Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp 
            100                 105                 110         


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Ser 
        115                 120                 125             


Leu Lys Cys Thr Asp Leu Lys Asn Asp Thr Asn Thr Asn Ser Ser Ser 
    130                 135                 140                 


Gly Arg Met Ile Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn 
145                 150                 155                 160 


Ile Ser Thr Ser Ile Arg Gly Lys Val Gln Lys Glu Tyr Ala Phe Phe 
                165                 170                 175     


Tyr Lys Leu Asp Ile Ile Pro Ile Asp Asn Asp Thr Thr Ser Tyr Lys 
            180                 185                 190         


Leu Thr Ser Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val 
        195                 200                 205             


Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala 
    210                 215                 220                 


Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Thr 
225                 230                 235                 240 


Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser 
                245                 250                 255     


Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile 
            260                 265                 270         


Arg Ser Val Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu 
        275                 280                 285             


Asn Thr Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg 
    290                 295                 300                 


Lys Arg Ile Arg Ile Gln Arg Gly Pro Gly Arg Ala Phe Val Thr Ile 
305                 310                 315                 320 


Gly Lys Ile Gly Asn Met Arg Gln Ala His Cys Asn Ile Ser Arg Ala 
                325                 330                 335     


Lys Trp Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln 
            340                 345                 350         


Phe Gly Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp 
        355                 360                 365             


Pro Glu Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
    370                 375                 380                 


Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp 
385                 390                 395                 400 


Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser Asp Thr Ile Thr Leu 
                405                 410                 415     


Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Lys Val Gly Lys 
            420                 425                 430         


Ala Met Tyr Ala Pro Pro Ile Ser Gly Gln Ile Arg Cys Ser Ser Asn 
        435                 440                 445             


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Ser Asn Asn Glu 
    450                 455                 460                 


Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
465                 470                 475                 480 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val 
                485                 490                 495     


Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg 
            500                 505                 510     


<210>  2
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is E or V

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is A or S

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is E, K or R

<400>  2

Lys Xaa Tyr Xaa Leu Phe Tyr Xaa 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  3

Lys Glu Tyr Ala Leu Phe Tyr Glu 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  4

Lys Glu Tyr Ala Leu Phe Tyr Lys 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  5

Lys Val Tyr Ser Leu Phe Tyr Arg 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  6

Lys Glu Tyr Ala Leu Phe Tyr Arg 
1               5               


<210>  7
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is V or K

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is Q or K

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is K or Q

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is E or V

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is Y or H

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is A or S

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is E or K, or R

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is I or V

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is P or Q

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is D or N

<400>  7

Lys Xaa Xaa Xaa Xaa Xaa Xaa Leu Phe Tyr Xaa Leu Asp Xaa Val Xaa 
1               5                   10                  15      


Ile Xaa 
        


<210>  8
<211>  18
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  8

Lys Val Gln Lys Glu Tyr Ala Leu Phe Tyr Glu Leu Asp Ile Val Pro 
1               5                   10                  15      


Ile Asp 
        


<210>  9
<211>  18
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  9

Lys Val Gln Lys Glu Tyr Ala Leu Phe Tyr Lys Leu Asp Val Val Pro 
1               5                   10                  15      


Ile Asp 
        


<210>  10
<211>  18
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  10

Lys Lys Gln Lys Val Tyr Ser Leu Phe Tyr Arg Leu Asp Val Val Gln 
1               5                   10                  15      


Ile Asn 
        


<210>  11
<211>  18
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  11

Lys Lys Lys Lys Glu Tyr Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro 
1               5                   10                  15      


Leu Asn 
        


<210>  12
<211>  18
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  12

Lys Lys Lys Gln Val His Ala Leu Phe Tyr Lys Leu Asp Val Val Gln 
1               5                   10                  15      


Ile Asp 
        


<210>  13
<211>  18
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  13

Lys Lys Gln Lys Val His Ala Leu Phe Tyr Lys Leu Asp Ile Val Gln 
1               5                   10                  15      


Ile Glu 
        


<210>  14
<211>  18
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  14

Lys Lys Lys Lys Val His Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro 
1               5                   10                  15      


Ile Asn 
        


<210>  15
<211>  29
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  15

Cys Ser Phe Asn Met Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys Val 
1               5                   10                  15      


Tyr Ser Leu Phe Tyr Arg Leu Asp Val Val Gln Ile Asn 
            20                  25                  


<210>  16
<211>  29
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  16

Cys Ser Phe Asn Ile Thr Thr Ser Ile Arg Asp Lys Val Gln Lys Glu 
1               5                   10                  15      


Tyr Ala Leu Phe Tyr Lys Leu Asp Val Val Pro Ile Asp 
            20                  25                  


<210>  17
<211>  29
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  17

Cys Ser Phe Asn Ala Thr Thr Glu Ile Arg Asp Lys Lys Lys Lys Glu 
1               5                   10                  15      


Tyr Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro Leu Asn 
            20                  25                  


<210>  18
<211>  29
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  18

Cys Ser Phe Asn Ile Thr Thr Glu Val Arg Asp Lys Lys Lys Gln Val 
1               5                   10                  15      


His Ala Leu Phe Tyr Lys Leu Asp Val Val Gln Ile Asp 
            20                  25                  


<210>  19
<211>  29
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  19

Cys Ser Phe Asn Met Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys Val 
1               5                   10                  15      


His Ala Leu Phe Tyr Lys Leu Asp Ile Val Gln Ile Glu 
            20                  25                  


<210>  20
<211>  29
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  20

Cys Ser Phe Asn Met Thr Thr Glu Val Arg Asp Lys Lys Lys Lys Val 
1               5                   10                  15      


His Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro Ile Asn 
            20                  25                  


<210>  21
<211>  41
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  21

Cys Ser Phe Lys Ile Thr Thr Asn Ile Arg Gly Lys Val Gln Lys Glu 
1               5                   10                  15      


Tyr Ala Leu Phe Tyr Glu Leu Asp Ile Val Pro Ile Asp Asn Asn Ser 
            20                  25                  30          


Asn Asn Arg Tyr Arg Leu Ile Ser Cys 
        35                  40      


<210>  22
<211>  12
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  22

Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr Ser Glu 
1               5                   10          


<210>  23
<211>  845
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  23

Met Arg Val Met Gly Ile Gln Arg Asn Cys Gln His Leu Leu Arg Trp 
1               5                   10                  15      


Gly Thr Met Ile Leu Gly Met Ile Ile Ile Cys Ser Ala Ala Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Met 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile His Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asn Val Asn Val Thr Asn Asn Thr Thr Asn Thr His Glu 
    130                 135                 140                 


Glu Glu Ile Lys Asn Cys Ser Phe Asn Met Thr Thr Glu Leu Arg Asp 
145                 150                 155                 160 


Lys Lys Gln Lys Val Tyr Ser Leu Phe Tyr Arg Leu Asp Val Val Gln 
                165                 170                 175     


Ile Asn Glu Asn Asn Ser Asn Ser Ser Tyr Arg Leu Ile Asn Cys Asn 
            180                 185                 190         


Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile 
        195                 200                 205             


Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys 
    210                 215                 220                 


Asp Lys Glu Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val 
225                 230                 235                 240 


Gln Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu 
                245                 250                 255     


Asn Gly Ser Leu Ala Glu Glu Glu Val Ile Ile Arg Ser Glu Asn Ile 
            260                 265                 270         


Thr Asn Asn Ala Lys Thr Ile Ile Val Gln Leu Thr Lys Pro Val Lys 
        275                 280                 285             


Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile 
    290                 295                 300                 


Gly Pro Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile 
305                 310                 315                 320 


Arg Gln Ala His Cys Asn Val Ser Arg Ser Glu Trp Asn Lys Thr Leu 
                325                 330                 335     


Gln Lys Val Ala Lys Gln Leu Arg Lys Tyr Phe Lys Asn Lys Thr Ile 
            340                 345                 350         


Ile Phe Thr Asn Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser 
        355                 360                 365             


Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe 
    370                 375                 380                 


Asn Ser Thr Trp Asn Asn Gly Thr Met Lys Asn Thr Ile Thr Leu Pro 
385                 390                 395                 400 


Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Arg Ala Gly Gln Ala 
                405                 410                 415     


Met Tyr Ala Pro Pro Ile Gln Gly Val Ile Arg Cys Glu Ser Asn Ile 
            420                 425                 430         


Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Asn Asn Thr Asn Glu 
        435                 440                 445             


Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu 
    450                 455                 460                 


Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro 
465                 470                 475                 480 


Thr Arg Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val Gly 
                485                 490                 495     


Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met 
            500                 505                 510         


Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser 
        515                 520                 525             


Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln 
    530                 535                 540                 


Gln His Leu Leu Lys Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala 
545                 550                 555                 560 


Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly 
                565                 570                 575     


Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Asn Val Pro Trp 
            580                 585                 590         


Asn Ser Ser Trp Ser Asn Lys Ser Gln Asn Glu Ile Trp Asp Asn Met 
        595                 600                 605             


Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser Asn Tyr Thr His Ile Ile 
    610                 615                 620                 


Tyr Asn Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln 
625                 630                 635                 640 


Asp Leu Leu Ala Leu Asp Lys Trp Ala Asn Leu Trp Asn Trp Phe Asp 
                645                 650                 655     


Ile Ser Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly 
            660                 665                 670         


Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Val Ile Asn 
        675                 680                 685             


Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His Thr Pro 
    690                 695                 700                 


Asn Pro Arg Gly Leu Asp Arg Pro Gly Arg Ile Glu Glu Glu Gly Gly 
705                 710                 715                 720 


Glu Gln Gly Arg Asp Arg Ser Ile Arg Leu Val Ser Gly Phe Leu Ala 
                725                 730                 735     


Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg 
            740                 745                 750         


Leu Arg Asp Phe Ile Leu Ile Ala Ala Arg Thr Val Glu Leu Leu Gly 
        755                 760                 765             


His Ser Ser Leu Lys Gly Leu Arg Leu Gly Trp Glu Gly Leu Lys Tyr 
    770                 775                 780                 


Leu Trp Asn Leu Leu Leu Tyr Trp Gly Arg Glu Leu Lys Ile Ser Ala 
785                 790                 795                 800 


Ile Asn Leu Val Asp Thr Ile Ala Ile Ala Val Ala Gly Trp Thr Asp 
                805                 810                 815     


Arg Val Ile Glu Ile Gly Gln Arg Ile Gly Arg Ala Ile Leu His Ile 
            820                 825                 830         


Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu 
        835                 840                 845 


<210>  24
<211>  843
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  24

Met Arg Val Met Gly Thr Gln Arg Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Ile Leu Ile Leu Gly Met Leu Ile Met Cys Lys Ala Thr Asp Leu 
            20                  25                  30          


Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Asp Thr 
        35                  40                  45              


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val His 
    50                  55                  60                  


Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Val Asn Leu Glu Asn Val Thr Glu Asp Phe Asn Met Trp Lys Asn 
                85                  90                  95      


Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln 
            100                 105                 110         


Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn 
        115                 120                 125             


Cys Ser Asn Ala Asn Thr Thr Asn Asn Ser Thr Met Glu Glu Ile Lys 
    130                 135                 140                 


Asn Cys Ser Tyr Asn Ile Thr Thr Glu Leu Arg Asp Lys Thr Gln Lys 
145                 150                 155                 160 


Val Tyr Ser Leu Phe Tyr Lys Leu Asp Val Val Gln Leu Asp Glu Ser 
                165                 170                 175     


Asn Lys Ser Glu Tyr Tyr Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala 
            180                 185                 190         


Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His 
        195                 200                 205             


Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp Pro Arg 
    210                 215                 220                 


Phe Asn Gly Thr Gly Ser Cys Asn Asn Val Ser Ser Val Gln Cys Thr 
225                 230                 235                 240 


His Gly Ile Lys Pro Val Ala Ser Thr Gln Leu Leu Leu Asn Gly Ser 
                245                 250                 255     


Leu Ala Glu Gly Lys Val Met Ile Arg Ser Glu Asn Ile Thr Asn Asn 
            260                 265                 270         


Ala Lys Asn Ile Ile Val Gln Phe Asn Lys Pro Val Pro Ile Thr Cys 
        275                 280                 285             


Ile Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Phe Gly Pro Gly 
    290                 295                 300                 


Gln Ala Phe Tyr Thr Asn Asp Ile Ile Gly Asp Ile Arg Gln Ala His 
305                 310                 315                 320 


Cys Asn Ile Asn Lys Thr Lys Trp Asn Ala Thr Leu Gln Lys Val Ala 
                325                 330                 335     


Glu Gln Leu Arg Glu His Phe Pro Asn Lys Thr Ile Ile Phe Thr Asn 
            340                 345                 350         


Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly 
        355                 360                 365             


Gly Glu Phe Phe Tyr Cys Asn Thr Thr Gly Leu Phe Asn Ser Thr Trp 
    370                 375                 380                 


Lys Asn Gly Thr Thr Asn Asn Thr Glu Gln Met Ile Thr Leu Pro Cys 
385                 390                 395                 400 


Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Arg Val Gly Arg Ala Met 
                405                 410                 415     


Tyr Ala Pro Pro Ile Ala Gly Val Ile Lys Cys Thr Ser Asn Ile Thr 
            420                 425                 430         


Gly Ile Ile Leu Thr Arg Asp Gly Gly Asn Asn Glu Thr Glu Thr Phe 
        435                 440                 445             


Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr 
    450                 455                 460                 


Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg 
465                 470                 475                 480 


Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val Gly Met Gly 
                485                 490                 495     


Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala 
            500                 505                 510         


Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile 
        515                 520                 525             


Val Gln Gln Gln Ser Asn Leu Leu Lys Ala Ile Glu Ala Gln Gln His 
    530                 535                 540                 


Leu Leu Lys Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val 
545                 550                 555                 560 


Leu Ala Leu Glu Arg Tyr Leu Gln Asp Gln Gln Leu Leu Gly Ile Trp 
                565                 570                 575     


Gly Cys Ser Gly Lys Leu Ile Cys Ala Thr Thr Val Pro Trp Asn Ser 
            580                 585                 590         


Ser Trp Ser Asn Lys Thr Gln Glu Glu Ile Trp Asn Asn Met Thr Trp 
        595                 600                 605             


Leu Gln Trp Asp Lys Glu Ile Ser Asn Tyr Thr Asn Ile Ile Tyr Lys 
    610                 615                 620                 


Leu Leu Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu 
625                 630                 635                 640 


Leu Ala Leu Asp Lys Trp Ala Asn Leu Trp Asn Trp Phe Asn Ile Thr 
                645                 650                 655     


Asn Trp Leu Trp Tyr Ile Arg Ile Phe Ile Met Ile Val Gly Gly Leu 
            660                 665                 670         


Ile Gly Leu Arg Ile Val Ile Ala Ile Ile Ser Val Val Asn Arg Val 
        675                 680                 685             


Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Ile Pro Thr Pro Asn Pro 
    690                 695                 700                 


Glu Gly Leu Asp Arg Pro Gly Arg Ile Glu Glu Gly Gly Gly Glu Gln 
705                 710                 715                 720 


Gly Arg Asp Arg Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu Ala 
                725                 730                 735     


Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg 
            740                 745                 750         


Asp Cys Ile Leu Ile Ala Ala Arg Thr Val Glu Leu Leu Gly His Ser 
        755                 760                 765             


Ser Leu Lys Gly Leu Arg Leu Gly Trp Glu Gly Leu Lys Tyr Leu Trp 
    770                 775                 780                 


Asn Leu Leu Leu Tyr Trp Gly Arg Glu Leu Lys Asn Ser Ala Ile Ser 
785                 790                 795                 800 


Leu Leu Asp Thr Ile Ala Val Ala Val Ala Glu Trp Thr Asp Arg Val 
                805                 810                 815     


Ile Glu Ile Gly Gln Arg Ala Cys Arg Ala Ile Leu Asn Ile Pro Arg 
            820                 825                 830         


Arg Ile Arg Gln Gly Phe Glu Arg Ala Leu Leu 
        835                 840             


<210>  25
<211>  841
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  25

Met Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Lys 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Leu Met Asn Ala Thr Asn Thr Asn Thr Thr Ile Ile 
    130                 135                 140                 


Tyr Arg Trp Arg Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr 
145                 150                 155                 160 


Ser Ile Arg Asp Lys Val Gln Lys Glu Tyr Ala Leu Phe Tyr Lys Leu 
                165                 170                 175     


Asp Val Val Pro Ile Asp Asn Asp Asn Thr Ser Tyr Arg Leu Ile Ser 
            180                 185                 190         


Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu 
        195                 200                 205             


Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys 
    210                 215                 220                 


Cys Asn Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Thr Asn Val Ser 
225                 230                 235                 240 


Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu 
                245                 250                 255     


Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Glu 
            260                 265                 270         


Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Glu Ser 
        275                 280                 285             


Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile 
    290                 295                 300                 


His Ile Gly Pro Gly Arg Ala Phe Tyr Thr Thr Gly Glu Ile Ile Gly 
305                 310                 315                 320 


Asp Ile Arg Gln Ala His Cys Asn Ile Ser Arg Ala Lys Trp Asn Asn 
                325                 330                 335     


Thr Leu Lys Gln Ile Val Lys Lys Leu Arg Glu Gln Phe Gly Asn Lys 
            340                 345                 350         


Thr Ile Val Phe Asn Gln Ser Ser Gly Gly Asp Pro Glu Ile Val Met 
        355                 360                 365             


His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Thr Gln 
    370                 375                 380                 


Leu Phe Asn Ser Thr Trp Asn Gly Thr Trp Asn Asn Thr Glu Gly Asn 
385                 390                 395                 400 


Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu 
                405                 410                 415     


Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys 
            420                 425                 430         


Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Asn 
        435                 440                 445             


Glu Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp 
    450                 455                 460                 


Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly 
465                 470                 475                 480 


Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg 
                485                 490                 495     


Ala Val Gly Ile Gly Ala Met Phe Leu Gly Phe Leu Gly Ala Ala Gly 
            500                 505                 510         


Ser Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln 
        515                 520                 525             


Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile 
    530                 535                 540                 


Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln 
545                 550                 555                 560 


Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln 
                565                 570                 575     


Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala 
            580                 585                 590         


Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Asp Glu Ile Trp 
        595                 600                 605             


Asp Asn Met Thr Trp Met Glu Trp Glu Arg Glu Ile Asp Asn Tyr Thr 
    610                 615                 620                 


Ser Leu Ile Tyr Thr Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys 
625                 630                 635                 640 


Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn 
                645                 650                 655     


Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met 
            660                 665                 670         


Ile Val Gly Gly Leu Val Gly Leu Arg Ile Val Phe Ala Val Leu Ser 
        675                 680                 685             


Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr 
    690                 695                 700                 


Arg Leu Pro Ala Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Glu 
705                 710                 715                 720 


Glu Gly Gly Glu Arg Asp Arg Asp Arg Ser Gly Arg Leu Val Asp Gly 
                725                 730                 735     


Phe Leu Ala Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser 
            740                 745                 750         


Tyr His Arg Leu Arg Asp Leu Leu Leu Ile Val Thr Arg Ile Val Glu 
        755                 760                 765             


Leu Leu Gly Arg Arg Gly Trp Glu Val Leu Lys Tyr Trp Trp Asn Leu 
    770                 775                 780                 


Leu Gln Tyr Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu 
785                 790                 795                 800 


Asn Ala Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Val Ile Glu 
                805                 810                 815     


Val Val Gln Arg Ala Cys Arg Ala Ile Leu His Ile Pro Arg Arg Ile 
            820                 825                 830         


Arg Gln Gly Leu Glu Arg Ala Leu Leu 
        835                 840     


<210>  26
<211>  835
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  26

Met Arg Val Arg Gly Ile Leu Arg Asn Cys Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Val Gly Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asn Ala Thr Asn Ala Thr Asn Thr Met Gly Glu Ile Lys 
    130                 135                 140                 


Asn Cys Ser Phe Asn Ile Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys 
145                 150                 155                 160 


Val Tyr Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro Leu Asn Glu Asn 
                165                 170                 175     


Asn Ser Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala 
            180                 185                 190         


Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro 
        195                 200                 205             


Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr 
    210                 215                 220                 


Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys 
225                 230                 235                 240 


Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu 
                245                 250                 255     


Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys Thr Ile 
            260                 265                 270         


Ile Val His Leu Asn Glu Ser Val Glu Ile Val Cys Thr Arg Pro Asn 
        275                 280                 285             


Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr 
    290                 295                 300                 


Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile 
305                 310                 315                 320 


Ser Glu Asp Lys Trp Asn Lys Thr Leu Gln Lys Val Ser Lys Lys Leu 
                325                 330                 335     


Lys Glu His Phe Pro Asn Lys Thr Ile Lys Phe Glu Pro Ser Ser Gly 
            340                 345                 350         


Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe 
        355                 360                 365             


Phe Tyr Cys Asn Thr Ser Lys Leu Phe Asn Ser Thr Tyr Asn Ser Thr 
    370                 375                 380                 


Asn Ser Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met 
385                 390                 395                 400 


Trp Gln Glu Val Gly Arg Ala Met Tyr Ala Pro Pro Ile Ala Gly Asn 
                405                 410                 415     


Ile Thr Cys Lys Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly 
            420                 425                 430         


Gly Lys Asn Asn Thr Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg 
        435                 440                 445             


Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys 
    450                 455                 460                 


Pro Leu Gly Ile Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg 
465                 470                 475                 480 


Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly 
                485                 490                 495     


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln 
            500                 505                 510         


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
        515                 520                 525             


Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly 
    530                 535                 540                 


Ile Lys Gln Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys 
545                 550                 555                 560 


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys 
                565                 570                 575     


Thr Thr Ala Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln Glu 
            580                 585                 590         


Asp Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Arg Glu Ile Ser 
        595                 600                 605             


Asn Tyr Thr Asp Thr Ile Tyr Arg Leu Leu Glu Asp Ser Gln Asn Gln 
    610                 615                 620                 


Gln Glu Lys Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn 
625                 630                 635                 640 


Leu Trp Asn Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile 
                645                 650                 655     


Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala 
            660                 665                 670         


Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser 
        675                 680                 685             


Phe Gln Thr Leu Thr Pro Asn Pro Arg Gly Pro Asp Arg Leu Gly Arg 
    690                 695                 700                 


Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Asp Arg Ser Ile Arg Leu 
705                 710                 715                 720 


Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg Ser Leu Cys 
                725                 730                 735     


Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu Ile Ala Ala Arg 
            740                 745                 750         


Ala Val Glu Leu Leu Gly Arg Ser Ser Leu Arg Gly Leu Gln Arg Gly 
        755                 760                 765             


Trp Glu Ala Leu Lys Tyr Leu Gly Ser Leu Val Gln Tyr Trp Gly Leu 
    770                 775                 780                 


Glu Leu Lys Lys Ser Ala Ile Ser Leu Leu Asp Thr Ile Ala Ile Ala 
785                 790                 795                 800 


Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Leu Ile Gln Arg Ile Cys 
                805                 810                 815     


Arg Ala Ile Arg Asn Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu Ala 
            820                 825                 830         


Ala Leu Gln 
        835 


<210>  27
<211>  840
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  27

Met Arg Val Arg Gly Ile Gln Arg Asn Tyr Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Ile Met Leu Leu Gly Met Leu Met Ile Cys Ser Val Ala Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ser Tyr Lys Thr Glu Ala 
    50                  55                  60                  


His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Glu Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Val Lys Arg Asn Asn Thr Ser Asn Asp Thr Asn Glu 
    130                 135                 140                 


Gly Glu Met Lys Asn Cys Ser Phe Asn Ile Thr Thr Glu Ile Arg Asp 
145                 150                 155                 160 


Lys Lys Lys Gln Val His Ala Leu Phe Tyr Lys Leu Asp Val Val Pro 
                165                 170                 175     


Ile Asp Asp Asn Asn Ser Asn Thr Ser Tyr Arg Leu Ile Asn Cys Asn 
            180                 185                 190         


Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val Thr Phe Glu Pro Ile 
        195                 200                 205             


Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys 
    210                 215                 220                 


Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val 
225                 230                 235                 240 


Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu 
                245                 250                 255     


Asn Gly Ser Leu Ala Glu Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu 
            260                 265                 270         


Thr Asn Asn Ala Lys Ile Ile Ile Val Gln Leu Asn Glu Ser Val Thr 
        275                 280                 285             


Ile Asn Cys Thr Arg Pro Tyr Asn Asn Thr Arg Gln Arg Thr Pro Ile 
    290                 295                 300                 


Gly Pro Gly Gln Ala Leu Tyr Thr Thr Arg Ile Lys Gly Asp Ile Arg 
305                 310                 315                 320 


Gln Ala His Cys Asn Ile Ser Arg Ala Glu Trp Asn Lys Thr Leu Gln 
                325                 330                 335     


Gln Val Ala Lys Lys Leu Gly Asp Leu Leu Asn Lys Thr Thr Ile Ile 
            340                 345                 350         


Phe Lys Pro Ser Ser Gly Gly Asp Pro Glu Ile Thr Thr His Ser Phe 
        355                 360                 365             


Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Arg Leu Phe Asn 
    370                 375                 380                 


Ser Thr Trp Asn Asn Thr Lys Trp Asn Ser Thr Gly Lys Ile Thr Leu 
385                 390                 395                 400 


Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Gly Val Gly Lys 
                405                 410                 415     


Ala Met Tyr Ala Pro Pro Ile Glu Gly Leu Ile Lys Cys Ser Ser Asn 
            420                 425                 430         


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Ala Asn Asn Ser His 
        435                 440                 445             


Asn Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
    450                 455                 460                 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val 
465                 470                 475                 480 


Ala Pro Thr Arg Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala 
                485                 490                 495     


Ile Gly Leu Gly Ala Met Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser 
            500                 505                 510         


Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu 
        515                 520                 525             


Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu 
    530                 535                 540                 


Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu 
545                 550                 555                 560 


Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu 
                565                 570                 575     


Leu Gly Ile Trp Gly Cys Ser Gly Lys His Ile Cys Thr Thr Thr Val 
            580                 585                 590         


Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Leu Asp Glu Ile Trp Asn 
        595                 600                 605             


Asn Met Thr Trp Met Glu Trp Glu Arg Glu Ile Asp Asn Tyr Thr Gly 
    610                 615                 620                 


Leu Ile Tyr Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 
625                 630                 635                 640 


Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp 
                645                 650                 655     


Phe Ser Ile Thr Gln Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile 
            660                 665                 670         


Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Leu 
        675                 680                 685             


Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu 
    690                 695                 700                 


Leu Pro Ala Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu 
705                 710                 715                 720 


Gly Gly Glu Gln Gly Arg Gly Arg Ser Ile Arg Leu Val Asn Gly Phe 
                725                 730                 735     


Ser Ala Leu Ile Trp Asp Asp Leu Arg Asn Leu Cys Leu Phe Ser Tyr 
            740                 745                 750         


His Arg Leu Arg Asp Leu Ile Leu Ile Ala Ala Arg Ile Val Glu Leu 
        755                 760                 765             


Leu Gly Arg Arg Gly Trp Glu Ala Leu Lys Tyr Leu Trp Asn Leu Leu 
    770                 775                 780                 


Gln Tyr Trp Ile Gln Glu Leu Lys Asn Ser Ala Ile Ser Leu Phe Asp 
785                 790                 795                 800 


Thr Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Val Ile Glu Ile 
                805                 810                 815     


Val Gln Arg Ala Cys Arg Ala Ile Leu Asn Ile Pro Thr Arg Ile Arg 
            820                 825                 830         


Gln Gly Leu Glu Arg Ala Leu Leu 
        835                 840 


<210>  28
<211>  832
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  28

Met Arg Val Arg Gly Met Gln Arg Asn Trp Gln His Leu Gly Lys Trp 
1               5                   10                  15      


Gly Leu Leu Phe Leu Gly Ile Leu Ile Ile Cys Asn Ala Ala Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ser Tyr Glu Lys Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asp Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Val Asn Ala Thr Asn Asn Asp Thr Asn Asp Asn Lys 
    130                 135                 140                 


Thr Gly Ala Ile Gln Asn Cys Ser Phe Asn Met Thr Thr Glu Val Arg 
145                 150                 155                 160 


Asp Lys Lys Leu Lys Val His Ala Leu Phe Tyr Lys Leu Asp Ile Val 
                165                 170                 175     


Pro Ile Ser Asn Asn Asn Ser Lys Tyr Arg Leu Ile Asn Cys Asn Thr 
            180                 185                 190         


Ser Thr Ile Thr Gln Ala Cys Pro Lys Val Ser Trp Asp Pro Ile Pro 
        195                 200                 205             


Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asp 
    210                 215                 220                 


Lys Arg Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln 
225                 230                 235                 240 


Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn 
                245                 250                 255     


Gly Ser Leu Ala Glu Glu Asp Ile Ile Ile Arg Ser Gln Asn Ile Ser 
            260                 265                 270         


Asp Asn Ala Lys Thr Ile Ile Val His Leu Asn Glu Ser Val Gln Ile 
        275                 280                 285             


Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile His Leu Gly 
    290                 295                 300                 


Pro Gly Gln Ala Phe Tyr Ala Thr Gly Glu Ile Ile Gly Asp Ile Arg 
305                 310                 315                 320 


Lys Ala His Cys Asn Ile Ser Gly Thr Gln Trp Asn Lys Thr Leu Glu 
                325                 330                 335     


Gln Val Lys Ala Lys Leu Lys Ser His Phe Pro Asn Lys Thr Ile Lys 
            340                 345                 350         


Phe Asn Ser Ser Ser Gly Gly Asp Leu Glu Ile Thr Met His Ser Phe 
        355                 360                 365             


Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn 
    370                 375                 380                 


Asp Thr Gly Ser Asn Gly Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln 
385                 390                 395                 400 


Ile Val Asn Met Trp Gln Glu Val Gly Arg Ala Met Tyr Ala Ala Pro 
                405                 410                 415     


Ile Ala Gly Asn Ile Thr Cys Asn Ser Asn Ile Thr Gly Leu Leu Leu 
            420                 425                 430         


Thr Arg Asp Gly Gly Gln Asn Asn Thr Glu Thr Phe Arg Pro Gly Gly 
        435                 440                 445             


Gly Asn Met Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val 
    450                 455                 460                 


Val Glu Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Gln 
465                 470                 475                 480 


Val Val Lys Arg Glu Arg Arg Ala Val Gly Ile Gly Ala Val Phe Leu 
                485                 490                 495     


Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr 
            500                 505                 510         


Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln 
        515                 520                 525             


Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu 
    530                 535                 540                 


Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu 
545                 550                 555                 560 


Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Leu Trp Gly Cys Ser Gly 
                565                 570                 575     


Lys Leu Ile Cys Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn 
            580                 585                 590         


Lys Ser Gln Asp Glu Ile Trp Asn Asn Met Thr Trp Met Glu Trp Glu 
        595                 600                 605             


Lys Glu Ile Ser Asn Tyr Ser Asn Ile Ile Tyr Arg Leu Ile Glu Glu 
    610                 615                 620                 


Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Ala Leu Asp 
625                 630                 635                 640 


Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp 
                645                 650                 655     


Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg 
            660                 665                 670         


Ile Val Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg Lys Gly Tyr 
        675                 680                 685             


Ser Pro Leu Ser Leu Gln Thr Leu Ile Pro Ser Pro Arg Glu Pro Asp 
    690                 695                 700                 


Arg Pro Glu Gly Ile Glu Glu Gly Gly Gly Glu Gln Gly Lys Asp Arg 
705                 710                 715                 720 


Ser Val Arg Leu Val Asn Gly Phe Leu Ala Leu Val Trp Asp Asp Leu 
                725                 730                 735     


Arg Asn Leu Cys Leu Phe Ser Tyr Arg His Leu Arg Asp Phe Ile Leu 
            740                 745                 750         


Ile Ala Ala Arg Ile Val Asp Arg Gly Leu Arg Arg Gly Trp Glu Ala 
        755                 760                 765             


Leu Lys Tyr Leu Gly Asn Leu Thr Gln Tyr Trp Ser Gln Glu Leu Lys 
    770                 775                 780                 


Asn Ser Ala Ile Ser Leu Leu Asn Thr Thr Ala Ile Val Val Ala Glu 
785                 790                 795                 800 


Gly Thr Asp Arg Val Ile Glu Ala Leu Gln Arg Ala Gly Arg Ala Val 
                805                 810                 815     


Leu Asn Ile Pro Arg Arg Ile Arg Gln Gly Leu Glu Arg Ala Leu Leu 
            820                 825                 830         


<210>  29
<211>  831
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  29

Met Arg Val Arg Glu Met Gln Arg Asn Trp Gln His Leu Gly Lys Trp 
1               5                   10                  15      


Gly Leu Leu Phe Leu Gly Ile Leu Ile Ile Cys Asn Ala Ala Asp Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Arg Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr Tyr Ala Cys Val Pro Thr Asp Pro Ser Pro 
65                  70                  75                  80  


Gln Glu Leu Val Leu Gly Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Thr Asp Val Asn Val Thr Ile Asn Thr Thr Asn Val Thr Leu 
    130                 135                 140                 


Gly Glu Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr Glu Ile Lys Asp 
145                 150                 155                 160 


Lys Lys Lys Lys Glu Tyr Ala Leu Phe Tyr Arg Leu Asp Val Val Pro 
                165                 170                 175     


Ile Asn Asn Ser Ile Val Tyr Arg Leu Ile Ser Cys Asn Thr Ser Thr 
            180                 185                 190         


Val Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His 
        195                 200                 205             


Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys 
    210                 215                 220                 


Phe Asn Gly Thr Gly Leu Cys Arg Asn Val Ser Thr Val Gln Cys Thr 
225                 230                 235                 240 


His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser 
                245                 250                 255     


Leu Ala Glu Glu Asp Ile Ile Ile Arg Ser Glu Asn Ile Ser Asp Asn 
            260                 265                 270         


Thr Lys Thr Ile Ile Val Gln Phe Asn Arg Ser Val Glu Ile Asn Cys 
        275                 280                 285             


Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly 
    290                 295                 300                 


Arg Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Lys Ala 
305                 310                 315                 320 


Tyr Cys Asn Ile Asn Arg Thr Leu Trp Asn Glu Thr Leu Lys Lys Val 
                325                 330                 335     


Ala Glu Glu Phe Lys Asn His Phe Asn Ile Thr Val Thr Phe Asn Pro 
            340                 345                 350         


Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg 
        355                 360                 365             


Gly Glu Phe Phe Tyr Cys Asn Thr Ser Asp Leu Phe Asn Asn Thr Glu 
    370                 375                 380                 


Val Asn Asn Thr Lys Thr Ile Thr Leu Pro Cys Arg Ile Arg Gln Phe 
385                 390                 395                 400 


Val Asn Met Trp Gln Arg Val Gly Arg Ala Met Tyr Ala Pro Pro Ile 
                405                 410                 415     


Ala Gly Gln Ile Gln Cys Asn Ser Asn Ile Thr Gly Leu Leu Leu Thr 
            420                 425                 430         


Arg Asp Gly Gly Lys Asn Gly Ser Glu Thr Leu Arg Pro Gly Gly Gly 
        435                 440                 445             


Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val 
    450                 455                 460                 


Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Gln Val 
465                 470                 475                 480 


Val Gln Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Leu Leu Gly 
                485                 490                 495     


Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu 
            500                 505                 510         


Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser 
        515                 520                 525             


Asn Leu Leu Lys Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr 
    530                 535                 540                 


Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg 
545                 550                 555                 560 


Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys 
                565                 570                 575     


Leu Ile Cys Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys 
            580                 585                 590         


Ser Gln Asp Glu Ile Trp Asp Asn Met Thr Trp Met Gln Trp Glu Lys 
        595                 600                 605             


Glu Ile Ser Asn Tyr Thr Asp Thr Ile Tyr Arg Leu Ile Glu Asp Ala 
    610                 615                 620                 


Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys 
625                 630                 635                 640 


Trp Asp Asn Leu Trp Ser Trp Phe Thr Ile Thr Asn Trp Leu Trp Tyr 
                645                 650                 655     


Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile 
            660                 665                 670         


Val Phe Ala Val Leu Ser Val Val Asn Arg Val Arg Gln Gly Tyr Ser 
        675                 680                 685             


Pro Leu Ser Leu Gln Thr Leu Ile Pro Asn Pro Arg Gly Pro Glu Arg 
    690                 695                 700                 


Pro Gly Gly Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Asp Arg Ser 
705                 710                 715                 720 


Ile Arg Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg 
                725                 730                 735     


Ser Leu Cys Leu Phe Ser Tyr Arg His Leu Arg Asp Phe Ile Leu Ile 
            740                 745                 750         


Ala Ala Arg Thr Val Asp Met Gly Leu Lys Arg Gly Trp Glu Ala Leu 
        755                 760                 765             


Lys Tyr Leu Trp Asn Leu Pro Gln Tyr Trp Gly Gln Glu Leu Lys Asn 
    770                 775                 780                 


Ser Ala Ile Ser Leu Leu Asp Thr Thr Ala Ile Ala Val Ala Glu Gly 
785                 790                 795                 800 


Thr Asp Arg Ile Ile Glu Val Leu Gln Arg Ala Gly Arg Ala Val Leu 
                805                 810                 815     


His Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu Arg Ala Leu Leu 
            820                 825                 830     


<210>  30
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Val Gly Lys Leu Lys Gln Asn Leu Leu Leu Ala Cys Leu Val Ile 
1               5                   10                  15      


Ser Ser Val Thr Val Phe Tyr Leu Gly Gln His Ala Met Glu Cys His 
            20                  25                  30          


His Arg Ile Glu Glu Arg Ser Gln Pro Val Lys Leu Glu Ser Thr Arg 
        35                  40                  45              


Thr Thr Val Arg Thr Gly Leu Asp Leu Lys Ala Asn Lys Thr Phe Ala 
    50                  55                  60                  


Tyr His Lys Asp Met Pro Leu Ile Phe Ile Gly Gly Val Pro Arg Ser 
65                  70                  75                  80  


Gly Thr Thr Leu Met Arg Ala Met Leu Asp Ala His Pro Asp Ile Arg 
                85                  90                  95      


Cys Gly Glu Glu Thr Arg Val Ile Pro Arg Ile Leu Ala Leu Lys Gln 
            100                 105                 110         


Met Trp Ser Arg Ser Ser Lys Glu Lys Ile Arg Leu Asp Glu Ala Gly 
        115                 120                 125             


Val Thr Asp Glu Val Leu Asp Ser Ala Met Gln Ala Phe Leu Leu Glu 
    130                 135                 140                 


Ile Ile Val Lys His Gly Glu Pro Ala Pro Tyr Leu Cys Asn Lys Asp 
145                 150                 155                 160 


Pro Phe Ala Leu Lys Ser Leu Thr Tyr Leu Ser Arg Leu Phe Pro Asn 
                165                 170                 175     


Ala Lys Phe Leu Leu Met Val Arg Asp Gly Arg Ala Ser Val His Ser 
            180                 185                 190         


Met Ile Ser Arg Lys Val Thr Ile Ala Gly Phe Asp Leu Asn Ser Tyr 
        195                 200                 205             


Arg Asp Cys Leu Thr Lys Trp Asn Arg Ala Ile Glu Thr Met Tyr Asn 
    210                 215                 220                 


Gln Cys Met Glu Val Gly Tyr Lys Lys Cys Met Leu Val His Tyr Glu 
225                 230                 235                 240 


Gln Leu Val Leu His Pro Glu Arg Trp Met Arg Thr Leu Leu Lys Phe 
                245                 250                 255     


Leu Gln Ile Pro Trp Asn His Ser Val Leu His His Glu Glu Met Ile 
            260                 265                 270         


Gly Lys Ala Gly Gly Val Ser Leu Ser Lys Val Glu Arg Ser Thr Asp 
        275                 280                 285             


Gln Val Ile Lys Pro Val Asn Val Gly Ala Leu Ser Lys Trp Val Gly 
    290                 295                 300                 


Lys Ile Pro Pro Asp Val Leu Gln Asp Met Ala Val Ile Ala Pro Met 
305                 310                 315                 320 


Leu Ala Lys Leu Gly Tyr Asp Pro Tyr Ala Asn Pro Pro Asn Tyr Gly 
                325                 330                 335     


Lys Pro Asp Pro Lys Ile Ile Glu Asn Thr Arg Arg Val Tyr Lys Gly 
            340                 345                 350         


Glu Phe Gln Leu Pro Asp Phe Leu Lys Glu Lys Pro Gln Thr Glu Gln 
        355                 360                 365             


Val Glu 
    370 


<210>  31
<211>  2062
<212>  DNA
<213>  Homo sapiens

<400>  31
agatgtgtga tcccgccacc tccccggacc ctggcggttg tcgctgagtt ggcgaccgcg       60

ggagacgctg ctgaggcggc ttcggttgcg ggtcggaacg gcgctgctct gcggggccgg      120

tccaggctgg cagctgccgg cgcttggcgg tgagggcggg ctcccgagtg gccccccacc      180

gaaggcggtg ggaccagcgg ctgaggccag gatgccgtcc aggcggcgcg gcggctcctc      240

actcatccca gatgttggtt atctttctga agtagactgt ccatggcctg aacattttcc      300

gaaaatcatt ttgagcaaaa tatctgttta ataacaagat aaccacatca agatggttgg      360

aaagctgaag cagaacttac tattggcatg tctggtgatt agttctgtga ctgtgtttta      420

cctgggccag catgccatgg aatgccatca ccggatagag gaacgtagcc agccagtcaa      480

attggagagc acaaggacca ctgtgagaac tggcctggac ctcaaagcca acaaaacctt      540

tgcctatcac aaagatatgc ctttaatatt tattggaggt gtgcctcgga gtggaaccac      600

actcatgagg gccatgctgg acgcacatcc tgacattcgc tgtggagagg aaaccagggt      660

cattccccga atcctggccc tgaagcagat gtggtcacgg tcaagtaaag agaagatccg      720

cctggatgag gctggtgtta ctgatgaagt gctggattct gccatgcaag ccttcttact      780

agaaattatc gttaagcatg gggagccagc cccttattta tgtaataaag atccttttgc      840

cctgaaatct ttaacttacc tttctaggtt attccccaat gccaaatttc tcctgatggt      900

ccgagatggc cgggcatcag tacattcaat gatttctcga aaagttacta tagctggatt      960

tgatctgaac agctataggg actgtttgac aaagtggaat cgtgctatag agaccatgta     1020

taaccagtgt atggaggttg gttataaaaa gtgcatgttg gttcactatg aacaacttgt     1080

cttacatcct gaacggtgga tgagaacact cttaaagttc ctccagattc catggaacca     1140

ctcagtattg caccatgaag agatgattgg gaaagctggg ggagtgtctc tgtcaaaagt     1200

ggagagatct acagaccaag taatcaagcc agtcaatgta ggagctctat caaaatgggt     1260

tgggaagata ccgccagatg ttttacaaga catggcagtg attgctccta tgcttgccaa     1320

gcttggatat gacccatatg ccaacccacc taactacgga aaacctgatc ccaaaattat     1380

tgaaaacact cgaagggtct ataagggaga attccaacta cctgactttc ttaaagaaaa     1440

accacagact gagcaagtgg agtagcagaa ccaggagcct cttccataca tgaggaaaga     1500

ttgctgcctt ttcagcagaa gggaaattcc taggattggc tgtcccctgc caagcttggt     1560

ggagcgtctg caccttggct gcgccgcctg tgcatttgcc agtttcctcc cactgagagg     1620

atggaggtgt ccgcacagct ttgggcctcg tgagggatct gcctcctgag caaagagctc     1680

ttgatcccga tttcatgcac agccctgcag taaggagccc agaaggaaca tgtgtttcct     1740

gttaaaactc ctcttgttct cttttcttac attatgacgt ttgttttcaa ggagagggtt     1800

taaaaatggg atcctgtaag cagacttggg cagtctcctt ttgaaatagg ttgtctgtac     1860

atgttctaat gttttgtaga acacgtgtgc ctgtttaagt gtattgatgt gaataatatt     1920

aaatatccta attatttaat tcattgtatt gtttctgaga agttgggaaa ttaccattat     1980

acatttacaa cctaatgact tttgtatttt atttttcaaa ataaaagctt tcaatgtgaa     2040

gcattctggt aaaaaaaaaa aa                                              2062


<210>  32
<211>  370
<212>  PRT
<213>  Mus musculus

<400>  32

Met Val Gly Lys Leu Lys Gln Asn Leu Leu Leu Ala Cys Leu Val Ile 
1               5                   10                  15      


Ser Ser Val Thr Val Phe Tyr Leu Gly Gln His Ala Met Glu Cys His 
            20                  25                  30          


His Arg Ile Glu Glu Arg Ser Gln Pro Ala Arg Leu Glu Asn Pro Lys 
        35                  40                  45              


Ala Thr Val Arg Ala Gly Leu Asp Ile Lys Ala Asn Lys Thr Phe Thr 
    50                  55                  60                  


Tyr His Lys Asp Met Pro Leu Ile Phe Ile Gly Gly Val Pro Arg Ser 
65                  70                  75                  80  


Gly Thr Thr Leu Met Arg Ala Met Leu Asp Ala His Pro Asp Ile Arg 
                85                  90                  95      


Cys Gly Glu Glu Thr Arg Val Ile Pro Arg Ile Leu Ala Leu Lys Gln 
            100                 105                 110         


Met Trp Ser Arg Ser Ser Lys Glu Lys Ile Arg Leu Asp Glu Ala Gly 
        115                 120                 125             


Val Thr Asp Glu Val Leu Asp Ser Ala Met Gln Ala Phe Leu Leu Glu 
    130                 135                 140                 


Val Ile Val Lys His Gly Glu Pro Ala Pro Tyr Leu Cys Asn Lys Asp 
145                 150                 155                 160 


Pro Phe Ala Leu Lys Ser Leu Thr Tyr Leu Ala Arg Leu Phe Pro Asn 
                165                 170                 175     


Ala Lys Phe Leu Leu Met Val Arg Asp Gly Arg Ala Ser Val His Ser 
            180                 185                 190         


Met Ile Ser Arg Lys Val Thr Ile Ala Gly Phe Asp Leu Asn Ser Tyr 
        195                 200                 205             


Arg Asp Cys Leu Thr Lys Trp Asn Arg Ala Ile Glu Thr Met Tyr Asn 
    210                 215                 220                 


Gln Cys Met Glu Val Gly Tyr Lys Lys Cys Met Leu Val His Tyr Glu 
225                 230                 235                 240 


Gln Leu Val Leu His Pro Glu Arg Trp Met Arg Thr Leu Leu Lys Phe 
                245                 250                 255     


Leu His Ile Pro Trp Asn His Ser Val Leu His His Glu Glu Met Ile 
            260                 265                 270         


Gly Lys Ala Gly Gly Val Ser Leu Ser Lys Val Glu Arg Ser Thr Asp 
        275                 280                 285             


Gln Val Ile Lys Pro Val Asn Val Gly Ala Leu Ser Lys Trp Val Gly 
    290                 295                 300                 


Lys Ile Pro Pro Asp Val Leu Gln Asp Met Ala Val Ile Ala Pro Met 
305                 310                 315                 320 


Leu Ala Lys Leu Gly Tyr Asp Pro Tyr Ala Asn Pro Pro Asn Tyr Gly 
                325                 330                 335     


Lys Pro Asp Pro Lys Ile Leu Glu Asn Thr Arg Arg Val Tyr Lys Gly 
            340                 345                 350         


Glu Phe Gln Leu Pro Asp Phe Leu Lys Glu Lys Pro Gln Thr Glu Gln 
        355                 360                 365             


Val Glu 
    370 


<210>  33
<211>  2054
<212>  DNA
<213>  Mus musculus

<400>  33
aaatcagaga ggcggacaca tcgcgcggcc cggctgcggg tagcctatgg cggcgtgcgt       60

gagatcccgc ggccacgcgg cggcgggagg caggagctga ggcggcgacc gcggccagtc      120

gctgctgagg cggccgcggg tgcgcttctc ggcggggccg ggcagggccg tcgcctggcg      180

gtgaggacgc gctcccgggg cgggcgctat ggccaccaac tagggcggcc ggagaagcgg      240

ccgaagccca agatgccgga gcgacggcac ggctgcgcct ccgccatcgt aggtgccgat      300

ccccttgcca cagtcgagtc tccatggcct gaccgtgtct tgacaataat tttgagcaaa      360

atctatgtct aataagaaga taaccacatc aagatggttg ggaagctgaa gcagaactta      420

ctcttggcgt gtctggtgat tagttctgtg accgtgtttt acctgggcca gcatgccatg      480

gagtgccatc accgaataga ggaacgtagc cagccagccc gactggagaa ccccaaggcg      540

actgtgcgag ctggcctcga catcaaagcc aacaaaacat tcacctatca caaagatatg      600

cctttaatat tcatcggggg tgtgcctcgg agcggcacca cactcatgag ggctatgctg      660

gacgcacatc ctgacatccg ctgtggagag gaaaccaggg tcatccctcg aatcctggcc      720

ctgaagcaga tgtggtcccg gtccagtaaa gagaagatcc gcttggatga ggcgggtgtc      780

acagatgaag tgctagattc tgccatgcaa gccttccttc tggaggtcat tgttaaacat      840

ggggagccgg caccttattt atgtaacaaa gatccgtttg ccctgaaatc cttgacttac      900

cttgctaggt tatttcccaa tgccaaattt ctcctgatgg tccgagatgg ccgggcgtca      960

gtacattcaa tgatttctcg gaaagttact atagctggct ttgacctgaa cagctaccgg     1020

gactgtctga ccaagtggaa ccgggccata gaaaccatgt acaaccagtg tatggaagtt     1080

ggttataaga aatgcatgtt ggttcactat gaacagctcg tcttacaccc tgaacggtgg     1140

atgagaacgc tcttaaagtt cctccatatt ccatggaacc attccgtttt gcaccatgaa     1200

gaaatgatcg ggaaagctgg gggagtttct ctgtcaaagg tggaaagatc aacagaccaa     1260

gtcatcaaac ccgtcaacgt gggggcgcta tcgaagtggg ttgggaagat acccccggac     1320

gtcttacaag acatggccgt gattgcaccc atgctcgcca agcttggata tgacccatac     1380

gccaatcctc ctaactacgg aaaacctgac cccaagatcc ttgaaaacac caggagggtc     1440

tataaaggag aatttcagct ccctgacttt ctgaaagaaa aaccccagac ggagcaagtg     1500

gagtaactga gcccgtaact tcccacaggg acgactgctg ccttgtctac agaagggaaa     1560

tctcgggaac ggctgtctgc tgcgacaagg agtgtctgtg cccatcgctc ctgttcacct     1620

gccagcctcc tgtccccagg gggggtgtca cacacccggg cctccccaag tgatggctct     1680

tgagcccagg aacatgcatg gccctcagga tgaggagccc agcagggaca cagttctgtc     1740

acagctcctc ttgtccttgt ctttccttcc caggttccag tctttaattt caaggaaagg     1800

agagtttgaa gttggcattc tgttaacaaa atcaggcagt ctcattccga ataggttcta     1860

tgtacacgtt ccgatgtttt gtagaacact cgtgcctgtt gaaacgtatc gatgtggata     1920

atagtaaata ccttaattat ttaaataatt cattgtattg tttcagagac gtttggaaat     1980

tactgtatac atttacaacc taatgacttt tgtattttat ttttcaaaat aaaagcttaa     2040

atgtgaagca ctca                                                       2054


<210>  34
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Arg Leu Ser Val Arg Arg Val Leu Leu Ala Ala Gly Cys Ala Leu 
1               5                   10                  15      


Val Leu Val Leu Ala Val Gln Leu Gly Gln Gln Val Leu Glu Cys Arg 
            20                  25                  30          


Ala Val Leu Ala Gly Leu Arg Ser Pro Arg Gly Ala Met Arg Pro Glu 
        35                  40                  45              


Gln Glu Glu Leu Val Met Val Gly Thr Asn His Val Glu Tyr Arg Tyr 
    50                  55                  60                  


Gly Lys Ala Met Pro Leu Ile Phe Val Gly Gly Val Pro Arg Ser Gly 
65                  70                  75                  80  


Thr Thr Leu Met Arg Ala Met Leu Asp Ala His Pro Glu Val Arg Cys 
                85                  90                  95      


Gly Glu Glu Thr Arg Ile Ile Pro Arg Val Leu Ala Met Arg Gln Ala 
            100                 105                 110         


Trp Ser Lys Ser Gly Arg Glu Lys Leu Arg Leu Asp Glu Ala Gly Val 
        115                 120                 125             


Thr Asp Glu Val Leu Asp Ala Ala Met Gln Ala Phe Ile Leu Glu Val 
    130                 135                 140                 


Ile Ala Lys His Gly Glu Pro Ala Arg Val Leu Cys Asn Lys Asp Pro 
145                 150                 155                 160 


Phe Thr Leu Lys Ser Ser Val Tyr Leu Ser Arg Leu Phe Pro Asn Ser 
                165                 170                 175     


Lys Phe Leu Leu Met Val Arg Asp Gly Arg Ala Ser Val His Ser Met 
            180                 185                 190         


Ile Thr Arg Lys Val Thr Ile Ala Gly Phe Asp Leu Ser Ser Tyr Arg 
        195                 200                 205             


Asp Cys Leu Thr Lys Trp Asn Lys Ala Ile Glu Val Met Tyr Ala Gln 
    210                 215                 220                 


Cys Met Glu Val Gly Lys Glu Lys Cys Leu Pro Val Tyr Tyr Glu Gln 
225                 230                 235                 240 


Leu Val Leu His Pro Arg Arg Ser Leu Lys Leu Ile Leu Asp Phe Leu 
                245                 250                 255     


Gly Ile Ala Trp Ser Asp Ala Val Leu His His Glu Asp Leu Ile Gly 
            260                 265                 270         


Lys Pro Gly Gly Val Ser Leu Ser Lys Ile Glu Arg Ser Thr Asp Gln 
        275                 280                 285             


Val Ile Lys Pro Val Asn Leu Glu Ala Leu Ser Lys Trp Thr Gly His 
    290                 295                 300                 


Ile Pro Gly Asp Val Val Arg Asp Met Ala Gln Ile Ala Pro Met Leu 
305                 310                 315                 320 


Ala Gln Leu Gly Tyr Asp Pro Tyr Ala Asn Pro Pro Asn Tyr Gly Asn 
                325                 330                 335     


Pro Asp Pro Phe Val Ile Asn Asn Thr Gln Arg Val Leu Lys Gly Asp 
            340                 345                 350         


Tyr Lys Thr Pro Ala Asn Leu Lys Gly Tyr Phe Gln Val Asn Gln Asn 
        355                 360                 365             


Ser Thr Ser Ser His Leu Gly Ser Ser 
    370                 375         


<210>  35
<211>  2018
<212>  DNA
<213>  Homo sapiens

<400>  35
gagaggcagg cccatcgcaa ggctgactga tccttcaaag gagcctccca gctaaaagcc       60

agcaggagag agaccttggc caccaagggt ctgccagctc ctggtggtcc ccactccagc      120

cacctgccag ctcgagcctg accctcgcct ccaccctggc tgctgcctgt accgctctca      180

gggctctgcc agcagacagc cttggcacac aggcacaagg gctggagccc agagatgaga      240

gtgcccaagg gagatgtgag cctggcgggc tgcccgctaa cctgtcgctg aagccccaga      300

agcgggccct caggccaggc ctaccctgcc tccggcccag catgcgcctg tcggtgcgga      360

gggtgctgct ggcagccggc tgcgccctgg tcctggtgct ggcggttcag ctgggacagc      420

aggtgctaga gtgccgggcg gtgctggcgg gcctgcggag cccccggggg gccatgcggc      480

ctgagcagga ggagctggtg atggtgggca ccaaccacgt ggaataccgc tatggcaagg      540

ccatgccgct catcttcgtg ggtggcgtgc ctcgcagtgg caccacgttg atgcgcgcca      600

tgctggacgc gcaccccgag gtgcgctgcg gcgaggagac ccgcatcatc ccgcgcgtgc      660

tggccatgcg ccaggcctgg tccaagtctg gccgtgagaa gctgcggctg gatgaggcgg      720

gggtgacgga tgaggtgctg gacgccgcca tgcaggcctt catcctggag gtgattgcca      780

agcacggaga gccggcccgc gtgctctgca acaaggaccc atttacgctc aagtcctcgg      840

tctacctgtc gcgcctgttc cccaactcca agttcctgct gatggtgcgg gacggccggg      900

cctccgtgca ctccatgatc acgcgcaaag tcaccattgc gggctttgac ctcagcagct      960

accgtgactg cctcaccaag tggaacaagg ccatcgaggt gatgtacgcc cagtgcatgg     1020

aggtaggcaa ggagaagtgc ctgcctgtgt actacgagca gctggtgctg caccccaggc     1080

gctcactcaa gctcatcctc gacttcctcg gcatcgcctg gagcgacgct gtcctccacc     1140

atgaagacct cattggcaag cccggtggtg tctccctgtc caagatcgag cggtccacgg     1200

accaggtcat caagcctgtt aacctggaag cgctctccaa gtggactggc cacatccctg     1260

gggatgtggt gcgggacatg gcccagatcg cccccatgct ggctcagctc ggctatgacc     1320

cttatgcaaa cccccccaac tatggcaacc ctgacccctt cgtcatcaac aacacacagc     1380

gggtcttgaa aggggactat aaaacaccag ccaatctgaa aggatatttt caggtgaacc     1440

agaacagcac ctcctcccac ttaggaagct cgtgatttcc agatctccgc aaatgacttc     1500

attgccaaga agagaagaaa atgcatttaa gtggaaatcg gacctctaat ccaagcatat     1560

tgcttgctat taatcgccaa aacaggactg ctgatgagga atgtatttgc atatgtttgc     1620

aaaagctgaa tcattgaaaa cgtaccttga aactctctat ctctggacac tccagggtag     1680

agaatgaagg gtatggaagt agtccggctt ttgaaactta ggtattttat atttttcccc     1740

tcaagaactt ttttttaaga gacagatttg ccatcctcct taatttgcag gactgccttg     1800

gtggctttgt ttgctgggac aaggcccaca acctgtgcct ctcctattga cccttacttt     1860

gaattcaaag aatctattta agagtttaat atatgaggct ttctttgatt cctcctcagt     1920

tctacctagt ttcacagagg aaaaaaatac tctttgaata aagtgaacag aggctcattt     1980

gtttgtgcct tactttactg aaaaaaaaaa aaaaaaaa                             2018


<210>  36
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Arg Leu Ser Val Arg Arg Val Leu Leu Ala Ala Gly Cys Ala Leu 
1               5                   10                  15      


Val Leu Val Leu Ala Val Gln Leu Gly Gln Gln Val Leu Glu Cys Arg 
            20                  25                  30          


Ala Val Leu Ala Gly Leu Arg Ser Pro Arg Gly Ala Met Arg Pro Glu 
        35                  40                  45              


Gln Glu Glu Leu Val Met Val Gly Thr Asn His Val Glu Tyr Arg Tyr 
    50                  55                  60                  


Gly Lys Ala Met Pro Leu Ile Phe Val Gly Gly Val Pro Arg Ser Gly 
65                  70                  75                  80  


Thr Thr Leu Met Arg Ala Met Leu Asp Ala His Pro Glu Val Arg Cys 
                85                  90                  95      


Gly Glu Glu Thr Arg Ile Ile Pro Arg Val Leu Ala Met Arg Gln Ala 
            100                 105                 110         


Trp Ser Lys Ser Gly Arg Glu Lys Leu Arg Leu Asp Glu Ala Gly Val 
        115                 120                 125             


Thr Asp Glu Val Leu Asp Ala Ala Met Gln Ala Phe Ile Leu Glu Val 
    130                 135                 140                 


Ile Ala Lys His Gly Glu Pro Ala Arg Val Leu Cys Asn Lys Asp Pro 
145                 150                 155                 160 


Phe Thr Leu Lys Ser Ser Val Tyr Leu Ser Arg Leu Phe Pro Asn Ser 
                165                 170                 175     


Lys Phe Leu Leu Met Val Arg Asp Gly Arg Ala Ser Val His Ser Met 
            180                 185                 190         


Ile Thr Arg Lys Val Thr Ile Ala Gly Phe Asp Leu Ser Ser Tyr Arg 
        195                 200                 205             


Asp Cys Leu Thr Lys Trp Asn Lys Ala Ile Glu Val Met Tyr Ala Gln 
    210                 215                 220                 


Cys Met Glu Val Gly Lys Glu Lys Cys Leu Pro Val Tyr Tyr Glu Gln 
225                 230                 235                 240 


Leu Val Leu His Pro Arg Arg Ser Leu Lys Leu Ile Leu Asp Phe Leu 
                245                 250                 255     


Gly Ile Ala Trp Ser Asp Ala Val Leu His His Glu Asp Leu Ile Gly 
            260                 265                 270         


Lys Pro Gly Gly Val Ser Leu Ser Lys Ile Glu Arg Ser Thr Asp Gln 
        275                 280                 285             


Val Ile Lys Pro Val Asn Leu Glu Ala Leu Ser Lys Trp Thr Gly His 
    290                 295                 300                 


Ile Pro Gly Asp Val Val Arg Asp Met Ala Gln Ile Ala Pro Met Leu 
305                 310                 315                 320 


Ala Gln Leu Gly Tyr Asp Pro Tyr Ala Asn Pro Pro Asn Tyr Gly Asn 
                325                 330                 335     


Pro Asp Pro Phe Val Ile Asn Asn Thr Gln Arg Val Leu Lys Gly Asp 
            340                 345                 350         


Tyr Lys Thr Pro Ala Asn Leu Lys Gly Tyr Phe Gln Val Asn Gln Asn 
        355                 360                 365             


Ser Thr Ser Ser His Leu Gly Ser Ser 
    370                 375         


<210>  37
<211>  1910
<212>  DNA
<213>  Homo sapiens

<400>  37
cttccccggc tggggcggct ggagagccgg gagtcgctgg gtgcgtgggg ctgcctcgcc       60

gcgtctcgcc acgggctctg ccagcagaca gccttggcac acaggcacaa gggctggagc      120

ccagagatga gagtgcccaa gggagatgtg agcctggcgg gctgcccgct aacctgtcgc      180

tgaagcccca gaagcgggcc ctcaggccag gcctaccctg cctccggccc agcatgcgcc      240

tgtcggtgcg gagggtgctg ctggcagccg gctgcgccct ggtcctggtg ctggcggttc      300

agctgggaca gcaggtgcta gagtgccggg cggtgctggc gggcctgcgg agcccccggg      360

gggccatgcg gcctgagcag gaggagctgg tgatggtggg caccaaccac gtggaatacc      420

gctatggcaa ggccatgccg ctcatcttcg tgggtggcgt gcctcgcagt ggcaccacgt      480

tgatgcgcgc catgctggac gcgcaccccg aggtgcgctg cggcgaggag acccgcatca      540

tcccgcgcgt gctggccatg cgccaggcct ggtccaagtc tggccgtgag aagctgcggc      600

tggatgaggc gggggtgacg gatgaggtgc tggacgccgc catgcaggcc ttcatcctgg      660

aggtgattgc caagcacgga gagccggccc gcgtgctctg caacaaggac ccatttacgc      720

tcaagtcctc ggtctacctg tcgcgcctgt tccccaactc caagttcctg ctgatggtgc      780

gggacggccg ggcctccgtg cactccatga tcacgcgcaa agtcaccatt gcgggctttg      840

acctcagcag ctaccgtgac tgcctcacca agtggaacaa ggccatcgag gtgatgtacg      900

cccagtgcat ggaggtaggc aaggagaagt gcctgcctgt gtactacgag cagctggtgc      960

tgcaccccag gcgctcactc aagctcatcc tcgacttcct cggcatcgcc tggagcgacg     1020

ctgtcctcca ccatgaagac ctcattggca agcccggtgg tgtctccctg tccaagatcg     1080

agcggtccac ggaccaggtc atcaagcctg ttaacctgga agcgctctcc aagtggactg     1140

gccacatccc tggggatgtg gtgcgggaca tggcccagat cgcccccatg ctggctcagc     1200

tcggctatga cccttatgca aaccccccca actatggcaa ccctgacccc ttcgtcatca     1260

acaacacaca gcgggtcttg aaaggggact ataaaacacc agccaatctg aaaggatatt     1320

ttcaggtgaa ccagaacagc acctcctccc acttaggaag ctcgtgattt ccagatctcc     1380

gcaaatgact tcattgccaa gaagagaaga aaatgcattt aagtggaaat cggacctcta     1440

atccaagcat attgcttgct attaatcgcc aaaacaggac tgctgatgag gaatgtattt     1500

gcatatgttt gcaaaagctg aatcattgaa aacgtacctt gaaactctct atctctggac     1560

actccagggt agagaatgaa gggtatggaa gtagtccggc ttttgaaact taggtatttt     1620

atatttttcc cctcaagaac ttttttttaa gagacagatt tgccatcctc cttaatttgc     1680

aggactgcct tggtggcttt gtttgctggg acaaggccca caacctgtgc ctctcctatt     1740

gacccttact ttgaattcaa agaatctatt taagagttta atatatgagg ctttctttga     1800

ttcctcctca gttctaccta gtttcacaga ggaaaaaaat actctttgaa taaagtgaac     1860

agaggctcat ttgtttgtgc cttactttac tgaaaaaaaa aaaaaaaaaa                1910


<210>  38
<211>  390
<212>  PRT
<213>  Mus musculus

<400>  38

Met Arg Arg Ala Pro Trp Leu Gly Leu Arg Pro Trp Leu Gly Met Arg 
1               5                   10                  15      


Leu Ser Val Arg Lys Val Leu Leu Ala Ala Gly Cys Ala Leu Ala Leu 
            20                  25                  30          


Val Leu Ala Val Gln Leu Gly Gln Gln Val Leu Glu Cys Arg Ala Val 
        35                  40                  45              


Leu Gly Gly Thr Arg Asn Pro Arg Arg Met Arg Pro Glu Gln Glu Glu 
    50                  55                  60                  


Leu Val Met Leu Gly Ala Asp His Val Glu Tyr Arg Tyr Gly Lys Ala 
65                  70                  75                  80  


Met Pro Leu Ile Phe Val Gly Gly Val Pro Arg Ser Gly Thr Thr Leu 
                85                  90                  95      


Met Arg Ala Met Leu Asp Ala His Pro Glu Val Arg Cys Gly Glu Glu 
            100                 105                 110         


Thr Arg Ile Ile Pro Arg Val Leu Ala Met Arg Gln Ala Trp Thr Lys 
        115                 120                 125             


Ser Gly Arg Glu Lys Leu Arg Leu Asp Glu Ala Gly Val Thr Asp Glu 
    130                 135                 140                 


Val Leu Asp Ala Ala Met Gln Ala Phe Ile Leu Glu Val Ile Ala Lys 
145                 150                 155                 160 


His Gly Glu Pro Ala Arg Val Leu Cys Asn Lys Asp Pro Phe Thr Leu 
                165                 170                 175     


Lys Ser Ser Val Tyr Leu Ala Arg Leu Phe Pro Asn Ser Lys Phe Leu 
            180                 185                 190         


Leu Met Val Arg Asp Gly Arg Ala Ser Val His Ser Met Ile Thr Arg 
        195                 200                 205             


Lys Val Thr Ile Ala Gly Phe Asp Leu Ser Ser Tyr Arg Asp Cys Leu 
    210                 215                 220                 


Thr Lys Trp Asn Lys Ala Ile Glu Val Met Tyr Ala Gln Cys Met Glu 
225                 230                 235                 240 


Val Gly Arg Asp Lys Cys Leu Pro Val Tyr Tyr Glu Gln Leu Val Leu 
                245                 250                 255     


His Pro Arg Arg Ser Leu Lys Arg Ile Leu Asp Phe Leu Gly Ile Ala 
            260                 265                 270         


Trp Ser Asp Thr Val Leu His His Glu Asp Leu Ile Gly Lys Pro Gly 
        275                 280                 285             


Gly Val Ser Leu Ser Lys Ile Glu Arg Ser Thr Asp Gln Val Ile Lys 
    290                 295                 300                 


Pro Val Asn Leu Glu Ala Leu Ser Lys Trp Thr Gly His Ile Pro Arg 
305                 310                 315                 320 


Asp Val Val Arg Asp Met Ala Gln Ile Ala Pro Met Leu Ala Arg Leu 
                325                 330                 335     


Gly Tyr Asp Pro Tyr Ala Asn Pro Pro Asn Tyr Gly Asn Pro Asp Pro 
            340                 345                 350         


Ile Val Ile Asn Asn Thr His Arg Val Leu Lys Gly Asp Tyr Lys Thr 
        355                 360                 365             


Pro Ala Asn Leu Lys Gly Tyr Phe Gln Val Asn Gln Asn Ser Thr Ser 
    370                 375                 380                 


Pro His Leu Gly Ser Ser 
385                 390 


<210>  39
<211>  1830
<212>  DNA
<213>  Mus musculus

<400>  39
cctcgcggcg cctccctggc ggccggcagg gagccggagt ctgcgcgggc gccgatttgg       60

gcacggactg tcagggcagg aagccgtggt gaccaggctc gaggactggt gcttgaaaat      120

gagggcgccc aggggagatg tataccaggt gggcctgctg acccgtccat gaggcgggcc      180

ccctggctgg gcctgcgacc ctggctgggc atgcgcctgt cggtgcgtaa ggtgctgctg      240

gccgccggct gtgctctggc cctggtgctc gctgtgcagc ttgggcagca agtactggag      300

tgccgggcgg tgctcggggg cacacggaac ccacggagga tgcggccgga gcaggaggaa      360

ctggtgatgc tcggcgccga ccacgtggag taccgctatg gcaaggccat gccactcatc      420

tttgtgggcg gcgtgccacg cagtggcacc acgctcatgc gcgccatgtt ggacgcacac      480

ccagaggtgc gctgtgggga ggagacgcgc atcatccctc gtgtgctggc catgcggcag      540

gcctggacca agtctggccg tgagaagctg cggctggacg aggcaggtgt gacggatgag      600

gtgctggacg cggccatgca ggccttcatt ctggaggtga tcgccaagca cggcgaacca      660

gcccgcgtgc tgtgtaacaa ggaccccttc acactcaagt catccgtcta cctggcacgc      720

ctgttcccca actccaaatt cctgctaatg gtgcgtgacg gccgggcgtc cgtgcactcc      780

atgatcacgc gcaaggtcac catcgcgggc tttgacctca gcagctaccg agactgcctc      840

accaagtgga acaaggccat cgaggtgatg tacgcacagt gcatggaggt gggcagggac      900

aagtgcctgc ccgtgtacta tgagcagttg gtgctgcacc cccggcgctc actcaaacgc      960

atcctggact tcctgggcat cgcctggagt gacacagtcc tgcaccacga ggacctcatt     1020

ggcaagcctg ggggcgtctc cttgtccaag atcgagcggt ccacggacca ggtcatcaaa     1080

ccggtgaact tggaagctct ctccaagtgg acgggccaca tccctagaga cgtggtgagg     1140

gatatggccc agattgcccc catgctggcc cggcttggct atgacccgta tgcgaatcca     1200

cccaactatg ggaaccccga ccccattgtc atcaacaaca cacaccgggt cttgaaagga     1260

gactataaaa cgccagccaa tctgaaagga tattttcagg tgaaccagaa cagcacctcc     1320

ccacacctag gaagttcgtg atttccagtc cctgcagggc tcagacgcct cagtcctcga     1380

cctgcacacg gaagctggac taacccaagc acatggcttg ctctcagtca cgccgggcgg     1440

ggcctgccgg gttggagcat tcatacatct cggccaaagc gggcttggaa cctccgctcc     1500

aggacaacac taaggaggga gagactactt ccgcttcaga aacttggaga ttttctaatt     1560

tttctctcct tgggaacttt ttttttaaag aattgaattt gctatcttcc ctaacggaca     1620

gaccccttgg tgacctcatc tcctgggaca agaccggaga cccgtgcctc tccttgactg     1680

gacgttgaac tcaaaggatc tatttaagag tttaatatat gggctctcct tgctctagtc     1740

ctactcagtt tcacagagaa aagaaattaa ttatttgaat aaagtagaca ggctgctgtc     1800

tgtgccttac ttcaaaaaaa aaaaaaaaaa                                      1830


<210>  40
<211>  173
<212>  PRT
<213>  Helicobacter pylori

<400>  40

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  41
<211>  154
<212>  PRT
<213>  Aquifex pyrophilus

<400>  41

Met Gln Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly 
1               5                   10                  15      


Ile Val Ala Ser Arg Phe Asn His Ala Leu Val Asp Arg Leu Val Glu 
            20                  25                  30          


Gly Ala Ile Asp Ala Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile 
        35                  40                  45              


Thr Leu Val Arg Val Pro Gly Ser Trp Glu Ile Pro Val Ala Ala Gly 
    50                  55                  60                  


Glu Leu Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile Gly Val 
65                  70                  75                  80  


Leu Ile Arg Gly Ala Thr Pro His Phe Asp Tyr Ile Ala Ser Glu Val 
                85                  90                  95      


Ser Lys Gly Leu Ala Asp Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr 
            100                 105                 110         


Phe Gly Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Arg Ala 
        115                 120                 125             


Gly Thr Lys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Ser Ala Ile 
    130                 135                 140                 


Glu Met Ala Asn Leu Phe Lys Ser Leu Arg 
145                 150                 


<210>  42
<211>  265
<212>  PRT
<213>  Thermotoga sp. RQ2

<400>  42

Met Glu Phe Leu Lys Arg Ser Phe Ala Pro Leu Thr Glu Lys Gln Trp 
1               5                   10                  15      


Gln Glu Ile Asp Asn Arg Ala Arg Glu Ile Phe Lys Thr Gln Leu Tyr 
            20                  25                  30          


Gly Arg Lys Phe Val Asp Val Glu Gly Pro Tyr Gly Trp Glu Tyr Ala 
        35                  40                  45              


Ala His Pro Leu Gly Glu Val Glu Val Leu Ser Asp Glu Asn Glu Val 
    50                  55                  60                  


Val Lys Trp Gly Leu Arg Lys Ser Leu Pro Leu Ile Glu Leu Arg Ala 
65                  70                  75                  80  


Thr Phe Thr Leu Asp Leu Trp Glu Leu Asp Asn Leu Glu Arg Gly Lys 
                85                  90                  95      


Pro Asn Val Asp Leu Ser Ser Leu Glu Glu Thr Val Arg Lys Val Ala 
            100                 105                 110         


Glu Phe Glu Asp Glu Val Ile Phe Arg Gly Cys Glu Lys Ser Gly Val 
        115                 120                 125             


Lys Gly Leu Leu Ser Phe Glu Glu Arg Lys Ile Glu Cys Gly Ser Thr 
    130                 135                 140                 


Pro Lys Asp Leu Leu Glu Ala Ile Val Arg Ala Leu Ser Ile Phe Ser 
145                 150                 155                 160 


Lys Asp Gly Ile Glu Gly Pro Tyr Thr Leu Val Ile Asn Thr Asp Arg 
                165                 170                 175     


Trp Ile Asn Phe Leu Lys Glu Glu Ala Gly His Tyr Pro Leu Glu Lys 
            180                 185                 190         


Arg Val Glu Glu Cys Leu Arg Gly Gly Lys Ile Ile Thr Thr Pro Arg 
        195                 200                 205             


Ile Glu Asp Ala Leu Val Val Ser Glu Arg Gly Gly Asp Phe Lys Leu 
    210                 215                 220                 


Ile Leu Gly Gln Asp Leu Ser Ile Gly Tyr Glu Asp Arg Glu Lys Asp 
225                 230                 235                 240 


Ala Val Arg Leu Phe Ile Thr Glu Thr Phe Thr Phe Gln Val Val Asn 
                245                 250                 255     


Pro Glu Ala Leu Ile Leu Leu Lys Phe 
            260                 265 


<210>  43
<211>  309
<212>  PRT
<213>  Acidianus Tengchongensis

<400>  43

Tyr Leu Phe Arg Leu Cys Tyr Ser Cys Ala Ser Gln Met Val Trp Gly 
1               5                   10                  15      


Pro Trp Glu Pro Ile Tyr Glu Ile Lys Tyr Ala Asp Met Pro Ile Asn 
            20                  25                  30          


Thr Glu Met Thr Asp Phe Thr Ala Val Val Gly Lys Lys Phe Ala Glu 
        35                  40                  45              


Gly Lys Pro Leu Glu Ile Pro Val Ile Ser Gln Pro Tyr Gly Lys Arg 
    50                  55                  60                  


Val Val Ala Phe Gly Glu His Thr Val Ile Pro Gly Lys Glu Glu Gln 
65                  70                  75                  80  


Phe Glu Asp Ala Ile Ile Lys Thr Leu Glu Met Phe Lys Arg Ala Pro 
                85                  90                  95      


Gly Phe Leu Gly Ala Met Leu Leu Lys Glu Ile Gly Val Ser Gly Ile 
            100                 105                 110         


Gly Ser Phe Gln Phe Gly Ser Lys Gly Phe His Gln Leu Leu Glu Ser 
        115                 120                 125             


Pro Gly Ser Leu Glu Pro Asp Pro Asn Asn Val Met Tyr Gln Ala Pro 
    130                 135                 140                 


Glu Ala Lys Pro Thr Pro Pro Gln Tyr Ile Val His Val Glu Trp Ala 
145                 150                 155                 160 


Asn Leu Asp Ala Leu Gln Phe Gly Met Gly Arg Val Leu Leu Ser Pro 
                165                 170                 175     


Glu Tyr Arg Glu Val His Asp Glu Ala Leu Asp Thr Leu Ile Tyr Gly 
            180                 185                 190         


Pro Tyr Ile Arg Ile Ile Asn Pro Val Met Glu Gly Thr Phe Trp Arg 
        195                 200                 205             


Glu Tyr Leu Asn Glu Gly Ser Gly Pro Lys Pro Tyr Ile Ala Ile Asn 
    210                 215                 220                 


Met Ala Asp Leu Lys Asn Glu Pro Lys Thr Phe Glu Met Phe Ser Ala 
225                 230                 235                 240 


Val Gly Pro Lys Val Cys Met Val Thr Ala Arg His Pro Gly Phe Val 
                245                 250                 255     


Gly Phe Gln Asn His Val Gln Ile Gly Val Leu Pro Phe Gly Glu Arg 
            260                 265                 270         


Phe Gly Gly Ala Lys Met Asp Met Thr Lys Glu Ser Ser Thr Val Arg 
        275                 280                 285             


Val Leu Gln Tyr Thr Met Trp Lys Asp Trp Lys Asp His Glu Glu Met 
    290                 295                 300                 


His Arg Gln Asn Trp 
305                 


