                         SEQUENCE LISTING

<110>  Brown, Kurt
       Bassan, Merav
 
<120>  Fusion of Human Growth Hormone and Albumin, Formulation and Uses 
       Thereof

<130>  not known

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  776
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein of hGH and HSA

<400>  1

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Phe Pro Thr Ile Pro Leu Ser 
            580                 585                 590         


Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln Leu 
        595                 600                 605             


Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys Glu 
    610                 615                 620                 


Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe Ser 
625                 630                 635                 640 


Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys Ser 
                645                 650                 655     


Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu 
            660                 665                 670         


Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val Tyr 
        675                 680                 685             


Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu Glu 
    690                 695                 700                 


Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg Thr 
705                 710                 715                 720 


Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser His 
                725                 730                 735     


Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe Arg 
            740                 745                 750         


Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys Arg 
        755                 760                 765             


Ser Val Glu Gly Ser Cys Gly Phe 
    770                 775     


<210>  2
<211>  2403
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding fusion protein of hGH and HSA

<400>  2
atgaagtggg taagctttat ttcccttctt tttctcttta gctcggctta ttccaggagc       60

ttggataaaa gagatgcaca caagagtgag gttgctcatc ggtttaaaga tttgggagaa      120

gaaaatttca aagccttggt gttgattgcc tttgctcagt atcttcagca gtgtccattt      180

gaagatcatg taaaattagt gaatgaagta actgaatttg caaaaacatg tgttgctgat      240

gagtcagctg aaaattgtga caaatcactt catacccttt ttggagacaa attatgcaca      300

gttgcaactc ttcgtgaaac ctatggtgaa atggctgact gctgtgcaaa acaagaacct      360

gagagaaatg aatgcttctt gcaacacaaa gatgacaacc caaacctccc ccgattggtg      420

agaccagagg ttgatgtgat gtgcactgct tttcatgaca atgaagagac atttttgaaa      480

aaatacttat atgaaattgc cagaagacat ccttactttt atgccccgga actccttttc      540

tttgctaaaa ggtataaagc tgcttttaca gaatgttgcc aagctgctga taaagctgcc      600

tgcctgttgc caaagctcga tgaacttcgg gatgaaggga aggcttcgtc tgccaaacag      660

agactcaagt gtgccagtct ccaaaaattt ggagaaagag ctttcaaagc atgggcagta      720

gctcgcctga gccagagatt tcccaaagct gagtttgcag aagtttccaa gttagtgaca      780

gatcttacca aagtccacac ggaatgctgc catggagatc tgcttgaatg tgctgatgac      840

agggcggacc ttgccaagta tatctgtgaa aatcaagatt cgatctccag taaactgaag      900

gaatgctgtg aaaaacctct gttggaaaaa tcccactgca ttgccgaagt ggaaaatgat      960

gagatgcctg ctgacttgcc ttcattagct gctgattttg ttgaaagtaa ggatgtttgc     1020

aaaaactatg ctgaggcaaa ggatgtcttc ctgggcatgt ttttgtatga atatgcaaga     1080

aggcatcctg attactctgt cgtgctgctg ctgagacttg ccaagacata tgaaaccact     1140

ctagagaagt gctgtgccgc tgcagatcct catgaatgct atgccaaagt gttcgatgaa     1200

tttaaacctc ttgtggaaga gcctcagaat ttaatcaaac aaaattgtga gctttttgag     1260

cagcttggag agtacaaatt ccagaatgcg ctattagttc gttacaccaa gaaagtaccc     1320

caagtgtcaa ctccaactct tgtagaggtc tcaagaaacc taggaaaagt gggcagcaaa     1380

tgttgtaaac atcctgaagc aaaaagaatg ccctgtgcag aagactatct atccgtggtc     1440

ctgaaccagt tatgtgtgtt gcatgagaaa acgccagtaa gtgacagagt caccaaatgc     1500

tgcacagaat ccttggtgaa caggcgacca tgcttttcag ctctggaagt cgatgaaaca     1560

tacgttccca aagagtttaa tgctgaaaca ttcaccttcc atgcagatat atgcacactt     1620

tctgagaagg agagacaaat caagaaacaa actgcacttg ttgagctcgt gaaacacaag     1680

cccaaggcaa caaaagagca actgaaagct gttatggatg atttcgcagc ttttgtagag     1740

aagtgctgca aggctgacga taaggagacc tgctttgccg aggagggtaa aaaacttgtt     1800

gctgcaagtc aagctgcctt aggcttattc ccaacaattc ccttatccag gctttttgac     1860

aacgctatgc tccgcgccca tcgtctgcac cagctggcct ttgacaccta ccaggagttt     1920

gaagaagcct atatcccaaa ggaacagaag tattcattcc tgcagaaccc ccagacctcc     1980

ctctgtttct cagagtctat tccgacaccc tccaacaggg aggaaacaca acagaaatcc     2040

aacctagagc tgctccgcat ctccctgctg ctcatccagt cgtggctgga gcccgtgcag     2100

ttcctcagga gtgtcttcgc caacagcctg gtgtacggcg cctctgacag caacgtctat     2160

gacctcctaa aggacctaga ggaaggcatc caaacgctga tggggaggct ggaagatggc     2220

agcccccgga ctgggcagat cttcaagcag acctacagca agttcgacac aaactcacac     2280

aacgatgacg cactactcaa gaactacggg ctgctctact gcttcaggaa ggacatggac     2340

aaggtcgaga cattcctgcg catcgtgcag tgccgctctg tggagggatc ctgtggcttc     2400

taa                                                                   2403


