                         SEQUENCE LISTING

<110>  University of Pittsburgh - Of the Commonwealth System of 
       Higher Education
       Xu, Yan
       Tang, Pei
       Tillman, Tommy S
 
<120>  ENGINEERED RECEPTORS AND THEIR USE

<130>  8123-90314-02

<150>  61/735,503
<151>  2012-12-10

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Chloride Channel Receptor

<400>  1

Met Gly Leu Arg Ala Leu Met Leu Trp Leu Leu Ala Ala Ala Gly Leu 
1               5                   10                  15      


Val Arg Glu Ser Leu Gln Gly Gln Asp Met Val Ser Pro Pro Pro Pro 
            20                  25                  30          


Ile Ala Asp Glu Pro Leu Thr Val Asn Thr Gly Ile Tyr Leu Ile Glu 
        35                  40                  45              


Cys Tyr Ser Leu Asp Asp Lys Ala Glu Thr Phe Lys Val Asn Ala Phe 
    50                  55                  60                  


Leu Ser Leu Ser Trp Lys Asp Arg Arg Leu Ala Phe Asp Pro Val Arg 
65                  70                  75                  80  


Ser Gly Val Arg Val Lys Thr Tyr Glu Pro Glu Ala Ile Trp Ile Pro 
                85                  90                  95      


Glu Ile Arg Phe Val Asn Val Glu Asn Ala Arg Asp Ala Asp Val Val 
            100                 105                 110         


Asp Ile Ser Val Ser Pro Asp Gly Thr Val Gln Tyr Leu Glu Arg Phe 
        115                 120                 125             


Ser Ala Arg Val Leu Ser Pro Leu Asp Phe Arg Arg Tyr Pro Phe Asp 
    130                 135                 140                 


Ser Gln Thr Leu His Ile Tyr Leu Ile Val Arg Ser Val Asp Thr Arg 
145                 150                 155                 160 


Asn Ile Val Leu Ala Val Asp Leu Glu Lys Val Gly Lys Asn Asp Asp 
                165                 170                 175     


Val Phe Leu Thr Gly Trp Asp Ile Glu Ser Phe Thr Ala Val Val Lys 
            180                 185                 190         


Pro Ala Asn Phe Ala Leu Glu Asp Arg Leu Glu Ser Lys Leu Asp Tyr 
        195                 200                 205             


Gln Leu Arg Ile Ser Arg Gln Met Gly Tyr Tyr Leu Ile Gln Met Tyr 
    210                 215                 220                 


Ile Pro Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile 
225                 230                 235                 240 


Asn Met Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val 
                245                 250                 255     


Leu Thr Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys 
            260                 265                 270         


Val Ser Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu 
        275                 280                 285             


Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser 
    290                 295                 300                 


Arg Ser Gln Pro Ala Arg Ala Ala Lys Ile Asp Lys Ile Ser Arg Ile 
305                 310                 315                 320 


Gly Phe Pro Met Ala Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile 
                325                 330                 335     


Tyr Phe Gly Phe 
            340 


<210>  2
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Chloride Channel Receptor

<400>  2

Met Gly Leu Arg Ala Leu Met Leu Trp Leu Leu Ala Ala Ala Gly Leu 
1               5                   10                  15      


Val Arg Glu Ser Leu Gln Gly Gln Asp Met Val Ser Pro Pro Pro Pro 
            20                  25                  30          


Ile Ala Asp Glu Pro Leu Thr Val Asn Thr Gly Ile Tyr Leu Ile Glu 
        35                  40                  45              


Cys Tyr Ser Leu Asp Asp Lys Ala Glu Thr Phe Lys Val Asn Ala Phe 
    50                  55                  60                  


Leu Ser Leu Ser Trp Lys Asp Arg Arg Leu Ala Phe Asp Pro Val Arg 
65                  70                  75                  80  


Ser Gly Val Arg Val Lys Thr Tyr Glu Pro Glu Ala Ile Trp Ile Pro 
                85                  90                  95      


Glu Ile Arg Phe Val Asn Val Glu Asn Ala Arg Asp Ala Asp Val Val 
            100                 105                 110         


Asp Ile Ser Val Ser Pro Asp Gly Thr Val Gln Tyr Leu Glu Arg Phe 
        115                 120                 125             


Ser Ala Arg Val Leu Ser Pro Leu Asp Phe Arg Arg Tyr Pro Phe Asp 
    130                 135                 140                 


Ser Gln Thr Leu His Ile Tyr Leu Ile Val Arg Ser Val Asp Thr Arg 
145                 150                 155                 160 


Asn Ile Val Leu Ala Val Asp Leu Glu Lys Val Gly Lys Asn Asp Asp 
                165                 170                 175     


Val Phe Leu Thr Gly Trp Asp Ile Glu Ser Phe Thr Ala Val Val Lys 
            180                 185                 190         


Pro Ala Asn Phe Ala Leu Glu Asp Arg Leu Glu Ser Lys Leu Asp Tyr 
        195                 200                 205             


Gln Leu Arg Ile Ser Arg Gln Met Gly Tyr Tyr Leu Ile Gln Met Tyr 
    210                 215                 220                 


Ile Pro Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile 
225                 230                 235                 240 


Asn Met Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val 
                245                 250                 255     


Leu Thr Met Thr Thr Gln Ser Ile Gly Ser Arg Ala Ser Leu Pro Lys 
            260                 265                 270         


Val Ser Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu 
        275                 280                 285             


Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser 
    290                 295                 300                 


Arg Ser Gln Pro Ala Arg Ala Ala Lys Ile Asp Lys Ile Ser Arg Ile 
305                 310                 315                 320 


Gly Phe Pro Met Ala Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile 
                325                 330                 335     


Tyr Phe Gly Phe 
            340 


<210>  3
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Chloride Channel Receptor

<400>  3

Met Gly Leu Arg Ala Leu Met Leu Trp Leu Leu Ala Ala Ala Gly Leu 
1               5                   10                  15      


Val Arg Glu Ser Leu Gln Gly Gln Asp Met Val Ser Pro Pro Pro Pro 
            20                  25                  30          


Ile Ala Asp Glu Pro Leu Thr Val Asn Thr Gly Ile Tyr Leu Ile Glu 
        35                  40                  45              


Cys Tyr Ser Leu Asp Asp Lys Ala Glu Thr Phe Lys Val Asn Ala Phe 
    50                  55                  60                  


Leu Ser Leu Ser Trp Lys Asp Arg Arg Leu Ala Phe Asp Pro Val Arg 
65                  70                  75                  80  


Ser Gly Val Arg Val Lys Thr Tyr Glu Pro Glu Ala Ile Trp Ile Pro 
                85                  90                  95      


Glu Ile Arg Phe Val Asn Val Glu Asn Ala Arg Asp Ala Asp Val Val 
            100                 105                 110         


Asp Ile Ser Val Ser Pro Asp Gly Thr Val Gln Tyr Leu Glu Arg Phe 
        115                 120                 125             


Ser Ala Arg Val Leu Ser Pro Leu Asp Phe Arg Arg Tyr Pro Phe Asp 
    130                 135                 140                 


Ser Gln Thr Leu His Ile Tyr Leu Ile Val Arg Ser Val Asp Thr Arg 
145                 150                 155                 160 


Asn Ile Val Leu Ala Val Asp Leu Glu Lys Val Gly Lys Asn Asp Asp 
                165                 170                 175     


Val Phe Leu Thr Gly Trp Asp Ile Glu Ser Phe Thr Ala Val Val Lys 
            180                 185                 190         


Pro Ala Asn Phe Ala Leu Glu Asp Arg Leu Glu Ser Lys Leu Asp Tyr 
        195                 200                 205             


Gln Leu Arg Ile Ser Arg Gln Met Gly Tyr Tyr Leu Ile Gln Met Tyr 
    210                 215                 220                 


Ile Pro Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile 
225                 230                 235                 240 


Asn Met Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val 
                245                 250                 255     


Leu Thr Met Thr Thr Gln Ser Val Gly Ser Arg Ala Ser Leu Pro Lys 
            260                 265                 270         


Val Ser Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu 
        275                 280                 285             


Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser 
    290                 295                 300                 


Arg Ser Gln Pro Ala Arg Ala Ala Lys Ile Asp Lys Ile Ser Arg Ile 
305                 310                 315                 320 


Gly Phe Pro Met Ala Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile 
                325                 330                 335     


Tyr Phe Gly Phe 
            340 


<210>  4
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Chloride Channel Receptor

<400>  4

Met Gly Leu Arg Ala Leu Met Leu Trp Leu Leu Ala Ala Ala Gly Leu 
1               5                   10                  15      


Val Arg Glu Ser Leu Gln Gly Gln Asp Met Val Ser Pro Pro Pro Pro 
            20                  25                  30          


Ile Ala Asp Glu Pro Leu Thr Val Asn Thr Gly Ile Tyr Leu Ile Glu 
        35                  40                  45              


Cys Tyr Ser Leu Asp Asp Lys Ala Glu Thr Phe Lys Val Asn Ala Phe 
    50                  55                  60                  


Leu Ser Leu Ser Trp Lys Asp Arg Arg Leu Ala Phe Asp Pro Val Arg 
65                  70                  75                  80  


Ser Gly Val Arg Val Lys Thr Tyr Glu Pro Glu Ala Ile Trp Ile Pro 
                85                  90                  95      


Glu Ile Arg Phe Val Asn Val Glu Asn Ala Arg Asp Ala Asp Val Val 
            100                 105                 110         


Asp Ile Ser Val Ser Pro Asp Gly Thr Val Gln Tyr Leu Glu Arg Phe 
        115                 120                 125             


Ser Ala Arg Val Leu Ser Pro Leu Asp Phe Arg Arg Tyr Pro Phe Asp 
    130                 135                 140                 


Ser Gln Thr Leu His Ile Tyr Leu Ile Val Arg Ser Val Asp Thr Arg 
145                 150                 155                 160 


Asn Ile Val Leu Ala Val Asp Leu Glu Lys Val Gly Lys Asn Asp Asp 
                165                 170                 175     


Val Phe Leu Thr Gly Trp Asp Ile Glu Ser Phe Thr Ala Val Val Lys 
            180                 185                 190         


Pro Ala Asn Phe Ala Leu Glu Asp Arg Leu Glu Ser Lys Leu Asp Tyr 
        195                 200                 205             


Gln Leu Arg Ile Ser Arg Gln Met Gly Tyr Tyr Leu Ile Gln Met Tyr 
    210                 215                 220                 


Ile Pro Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile 
225                 230                 235                 240 


Asn Met Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val 
                245                 250                 255     


Leu Thr Met Thr Thr Gln Ser Ala Gly Ser Arg Ala Ser Leu Pro Lys 
            260                 265                 270         


Val Ser Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu 
        275                 280                 285             


Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser 
    290                 295                 300                 


Arg Ser Gln Pro Ala Arg Ala Ala Lys Ile Asp Lys Ile Ser Arg Ile 
305                 310                 315                 320 


Gly Phe Pro Met Ala Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile 
                325                 330                 335     


Tyr Phe Gly Phe 
            340 


<210>  5
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Chloride Channel Receptor

<400>  5

Met Gly Leu Arg Ala Leu Met Leu Trp Leu Leu Ala Ala Ala Gly Leu 
1               5                   10                  15      


Val Arg Glu Ser Leu Gln Gly Gln Asp Met Val Ser Pro Pro Pro Pro 
            20                  25                  30          


Ile Ala Asp Glu Pro Leu Thr Val Asn Thr Gly Ile Tyr Leu Ile Glu 
        35                  40                  45              


Cys Tyr Ser Ile Ala Glu Thr Thr Met Thr Phe Lys Val Asn Ala Phe 
    50                  55                  60                  


Leu Ser Leu Ser Trp Lys Asp Arg Arg Leu Ala Phe Asp Pro Val Arg 
65                  70                  75                  80  


Ser Gly Val Arg Val Lys Thr Tyr Glu Pro Glu Ala Ile Trp Ile Pro 
                85                  90                  95      


Glu Ile Arg Phe Val Asn Val Glu Asn Ala Arg Asp Ala Asp Val Val 
            100                 105                 110         


Asp Ile Ser Val Ser Pro Asp Gly Thr Val Gln Tyr Leu Glu Arg Phe 
        115                 120                 125             


Ser Ala Arg Val Leu Ser Pro Leu Asp Leu Lys Asn Phe Pro Met Asp 
    130                 135                 140                 


Ser Gln Thr Leu His Ile Tyr Leu Ile Val Arg Ser Val Asp Thr Arg 
145                 150                 155                 160 


Asn Ile Val Leu Ala Val Asp Leu Glu Lys Val Gly Lys Asn Asp Asp 
                165                 170                 175     


Val Phe Leu Thr Gly Trp Asp Ile Glu Ser Phe Thr Asp Gly Leu Thr 
            180                 185                 190         


Leu Pro Gln Phe Ala Leu Glu Asp Arg Leu Glu Ser Lys Leu Asp Tyr 
        195                 200                 205             


Gln Leu Arg Ile Ser Arg Gln Met Gly Tyr Tyr Leu Ile Gln Met Tyr 
    210                 215                 220                 


Ile Pro Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile 
225                 230                 235                 240 


Asn Met Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val 
                245                 250                 255     


Leu Thr Met Thr Thr Gln Ser Val Gly Ser Arg Ala Ser Leu Pro Lys 
            260                 265                 270         


Val Ser Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu 
        275                 280                 285             


Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser 
    290                 295                 300                 


Arg Ser Gln Pro Ala Arg Ala Ala Lys Ile Asp Lys Ile Ser Arg Ile 
305                 310                 315                 320 


Gly Phe Pro Met Ala Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile 
                325                 330                 335     


Tyr Phe Gly Phe 
            340 


<210>  6
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Chloride Channel Receptor

<400>  6

Met Gly Leu Arg Ala Leu Met Leu Trp Leu Leu Ala Ala Ala Gly Leu 
1               5                   10                  15      


Val Arg Glu Ser Leu Gln Gly Gln Asp Met Val Ser Pro Pro Pro Pro 
            20                  25                  30          


Ile Ala Asp Glu Pro Leu Thr Val Asn Thr Gly Ile Tyr Leu Ile Glu 
        35                  40                  45              


Cys Tyr Ser Ile Ala Glu Thr Thr Met Thr Phe Lys Val Asn Ala Phe 
    50                  55                  60                  


Leu Ser Leu Ser Trp Lys Asp Arg Arg Leu Ala Phe Asp Pro Val Arg 
65                  70                  75                  80  


Ser Gly Val Arg Val Lys Thr Tyr Glu Pro Glu Ala Ile Trp Ile Pro 
                85                  90                  95      


Glu Ile Arg Phe Val Asn Val Glu Asn Ala Arg Asp Ala Asp Val Val 
            100                 105                 110         


Asp Ile Ser Val Ser Pro Asp Gly Thr Val Gln Tyr Leu Glu Arg Phe 
        115                 120                 125             


Ser Ala Arg Val Leu Ser Pro Leu Asp Leu Lys Asn Phe Pro Met Asp 
    130                 135                 140                 


Ser Gln Thr Leu His Ile Tyr Leu Ile Val Arg Ser Val Asp Thr Arg 
145                 150                 155                 160 


Asn Ile Val Leu Ala Val Asp Leu Glu Lys Val Gly Lys Asn Asp Asp 
                165                 170                 175     


Val Phe Leu Thr Gly Trp Asp Ile Glu Ser Phe Thr Asp Gly Leu Thr 
            180                 185                 190         


Leu Pro Gln Phe Ala Leu Glu Asp Arg Leu Glu Ser Lys Leu Asp Tyr 
        195                 200                 205             


Gln Leu Arg Ile Ser Arg Gln Met Gly Tyr Tyr Leu Ile Gln Met Tyr 
    210                 215                 220                 


Ile Pro Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile 
225                 230                 235                 240 


Asn Met Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val 
                245                 250                 255     


Leu Thr Met Thr Thr Gln Ser Val Gly Ser Arg Ala Ser Leu Pro Lys 
            260                 265                 270         


Val Ser Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu 
        275                 280                 285             


Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser 
    290                 295                 300                 


Arg Ser Gln Pro Ala Arg Ala Ala Lys Ile Asp Lys Ile Ser Arg Ile 
305                 310                 315                 320 


Gly Phe Pro Met Ala Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile 
                325                 330                 335     


Tyr Lys Ile Val Arg Arg Glu Asp Val His Asn Gln 
            340                 345             


<210>  7
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Chloride Channel Receptor

<400>  7

Met Gly Leu Arg Ala Leu Met Leu Trp Leu Leu Ala Ala Ala Gly Leu 
1               5                   10                  15      


Val Arg Glu Ser Leu Gln Gly Gln Asp Met Val Ser Pro Pro Pro Pro 
            20                  25                  30          


Ile Ala Asp Glu Pro Leu Thr Val Asn Thr Gly Ile Tyr Leu Ile Glu 
        35                  40                  45              


Cys Tyr Ser Leu Asp Asp Lys Ala Glu Thr Phe Lys Val Asn Ala Phe 
    50                  55                  60                  


Leu Ser Leu Ser Trp Lys Asp Arg Arg Leu Ala Phe Asp Pro Val Arg 
65                  70                  75                  80  


Ser Gly Val Arg Val Lys Thr Tyr Glu Pro Glu Ala Ile Trp Ile Pro 
                85                  90                  95      


Glu Ile Arg Phe Val Asn Val Glu Asn Ala Arg Asp Ala Asp Val Val 
            100                 105                 110         


Asp Ile Ser Val Ser Pro Asp Gly Thr Val Gln Tyr Leu Glu Arg Phe 
        115                 120                 125             


Ser Ala Arg Val Leu Ser Pro Leu Asp Phe Arg Arg Tyr Pro Phe Asp 
    130                 135                 140                 


Ser Gln Thr Leu His Ile Tyr Leu Ile Val Arg Ser Val Asp Thr Arg 
145                 150                 155                 160 


Asn Ile Val Leu Ala Val Asp Leu Glu Lys Val Gly Lys Asn Asp Asp 
                165                 170                 175     


Val Phe Leu Thr Gly Trp Asp Ile Glu Ser Phe Thr Ala Val Val Lys 
            180                 185                 190         


Pro Ala Asn Phe Ala Leu Glu Asp Arg Leu Glu Ser Lys Leu Asp Tyr 
        195                 200                 205             


Gln Leu Arg Ile Ser Arg Gln Met Gly Tyr Tyr Leu Ile Gln Met Tyr 
    210                 215                 220                 


Ile Pro Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile 
225                 230                 235                 240 


Asn Met Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val 
                245                 250                 255     


Leu Thr Met Thr Thr Gln Ser Val Gly Ser Arg Thr Asn Leu Pro Lys 
            260                 265                 270         


Thr Pro Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu 
        275                 280                 285             


Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser 
    290                 295                 300                 


Arg Ser Gln Pro Ala Arg Ala Ala Lys Ile Asp Lys Ile Ser Arg Ile 
305                 310                 315                 320 


Gly Phe Pro Met Ala Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile 
                325                 330                 335     


Tyr Phe Gly Phe 
            340 


<210>  8
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Chloride Channel Receptor

<400>  8

Met Gly Leu Arg Ala Leu Met Leu Trp Leu Leu Ala Ala Ala Gly Leu 
1               5                   10                  15      


Val Arg Glu Ser Leu Gln Ala Pro Ala Asp Asn Ala Ala Asp Ala Arg 
            20                  25                  30          


Pro Val Asp Val Ser Val Ser Ile Phe Ile Asn Lys Ile Tyr Gly Val 
        35                  40                  45              


Asn Thr Leu Glu Gln Thr Tyr Lys Val Asp Gly Tyr Ile Val Ala Gln 
    50                  55                  60                  


Trp Thr Gly Lys Pro Arg Lys Thr Pro Gly Asp Lys Pro Leu Ile Val 
65                  70                  75                  80  


Glu Asn Thr Gln Ile Glu Arg Trp Ile Asn Asn Gly Leu Trp Val Pro 
                85                  90                  95      


Ala Leu Glu Phe Ile Asn Val Val Gly Ser Pro Asp Thr Gly Asn Lys 
            100                 105                 110         


Arg Leu Met Leu Phe Pro Asp Gly Arg Val Ile Tyr Asn Ala Arg Phe 
        115                 120                 125             


Leu Gly Ser Phe Ser Asn Asp Met Asp Phe Arg Leu Phe Pro Phe Asp 
    130                 135                 140                 


Arg Gln Gln Phe Val Leu Glu Leu Glu Pro Phe Ser Tyr Asn Asn Gln 
145                 150                 155                 160 


Gln Leu Arg Phe Ser Asp Ile Gln Val Tyr Thr Glu Asn Ile Asp Asn 
                165                 170                 175     


Glu Glu Ile Asp Glu Trp Trp Ile Arg Gly Lys Ala Ser Thr His Ile 
            180                 185                 190         


Ser Asp Ile Arg Tyr Asp His Leu Ser Ser Val Gln Pro Asn Gln Asn 
        195                 200                 205             


Glu Phe Ser Arg Ile Thr Val Arg Ile Asp Ala Val Arg Gln Met Gly 
    210                 215                 220                 


Tyr Tyr Leu Ile Gln Met Tyr Ile Pro Ser Leu Leu Ile Val Ile Leu 
225                 230                 235                 240 


Ser Trp Ile Ser Phe Trp Ile Asn Met Asp Ala Ala Pro Ala Arg Val 
                245                 250                 255     


Gly Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Gln Ser Ser Gly 
            260                 265                 270         


Ser Arg Ala Ser Leu Pro Lys Val Ser Tyr Val Lys Ala Ile Asp Ile 
        275                 280                 285             


Trp Met Ala Val Cys Leu Leu Phe Val Phe Ser Ala Leu Leu Glu Tyr 
    290                 295                 300                 


Ala Ala Val Asn Phe Val Ser Arg Ser Gln Pro Ala Arg Ala Ala Lys 
305                 310                 315                 320 


Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala Phe Leu Ile Phe 
                325                 330                 335     


Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg Arg Glu Asp Val 
            340                 345                 350         


His Asn Gln 
        355 


<210>  9
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Chloride Channel Receptor

<400>  9

Met Gly Leu Arg Ala Leu Met Leu Trp Leu Leu Ala Ala Ala Gly Leu 
1               5                   10                  15      


Val Arg Glu Ser Leu Gln Ala Pro Ala Asp Asn Ala Ala Asp Ala Arg 
            20                  25                  30          


Pro Val Asp Val Ser Val Ser Ile Phe Ile Asn Lys Ile Tyr Gly Val 
        35                  40                  45              


Asn Thr Leu Glu Gln Thr Tyr Lys Val Asp Gly Tyr Ile Val Ala Gln 
    50                  55                  60                  


Trp Thr Gly Lys Pro Arg Lys Thr Pro Gly Asp Lys Pro Leu Ile Val 
65                  70                  75                  80  


Glu Asn Thr Gln Ile Glu Arg Trp Ile Asn Asn Gly Leu Trp Val Pro 
                85                  90                  95      


Ala Leu Glu Phe Ile Asn Val Val Gly Ser Pro Asp Thr Gly Asn Lys 
            100                 105                 110         


Arg Leu Met Leu Phe Pro Asp Gly Arg Val Ile Tyr Asn Ala Arg Phe 
        115                 120                 125             


Leu Gly Ser Phe Ser Asn Asp Met Asp Phe Arg Leu Phe Pro Phe Asp 
    130                 135                 140                 


Arg Gln Gln Phe Val Leu Glu Leu Glu Pro Phe Ser Tyr Asn Asn Gln 
145                 150                 155                 160 


Gln Leu Arg Phe Ser Asp Ile Gln Val Tyr Thr Glu Asn Ile Asp Asn 
                165                 170                 175     


Glu Glu Ile Asp Glu Trp Trp Ile Arg Gly Lys Ala Ser Thr His Ile 
            180                 185                 190         


Ser Asp Ile Arg Tyr Asp His Leu Ser Ser Val Gln Pro Asn Gln Asn 
        195                 200                 205             


Glu Phe Ser Arg Ile Thr Val Arg Ile Asp Ala Gly Arg Asn Pro Ser 
    210                 215                 220                 


Tyr Tyr Leu Ile Gln Met Tyr Ile Pro Ser Leu Leu Ile Val Ile Leu 
225                 230                 235                 240 


Ser Trp Ile Ser Phe Trp Ile Asn Met Asp Ala Ala Pro Ala Arg Val 
                245                 250                 255     


Gly Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Gln Ser Ser Gly 
            260                 265                 270         


Ser Arg Ala Ser Leu Pro Arg Leu Pro Tyr Thr Thr Val Ile Asp Ile 
        275                 280                 285             


Trp Met Ala Val Cys Leu Leu Phe Val Phe Ser Ala Leu Leu Glu Tyr 
    290                 295                 300                 


Ala Ala Val Asn Phe Val Ser Arg Ser Gln Pro Ala Arg Ala Ala Lys 
305                 310                 315                 320 


Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala Phe Leu Ile Phe 
                325                 330                 335     


Asn Met Phe Tyr Trp Ile Arg Gly Ile Thr Leu 
            340                 345         


<210>  10
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Chloride Channel Receptor

<400>  10

Met Gly Leu Arg Ala Leu Met Leu Trp Leu Leu Ala Ala Ala Gly Leu 
1               5                   10                  15      


Val Arg Glu Ser Leu Gln Ala Pro Ala Asp Asn Ala Ala Asp Ala Arg 
            20                  25                  30          


Pro Val Asp Val Ser Val Ser Ile Phe Ile Asn Lys Ile Tyr Gly Val 
        35                  40                  45              


Asn Thr Leu Glu Gln Thr Tyr Lys Val Asp Gly Tyr Ile Val Ala Gln 
    50                  55                  60                  


Trp Thr Gly Lys Pro Arg Lys Thr Pro Gly Asp Lys Pro Leu Ile Val 
65                  70                  75                  80  


Glu Asn Thr Gln Ile Glu Arg Trp Ile Asn Asn Gly Leu Trp Val Pro 
                85                  90                  95      


Ala Leu Glu Phe Ile Asn Val Val Gly Ser Pro Asp Thr Gly Asn Lys 
            100                 105                 110         


Arg Leu Met Leu Phe Pro Asp Gly Arg Val Ile Tyr Asn Ala Arg Phe 
        115                 120                 125             


Leu Gly Ser Phe Ser Asn Asp Met Asp Phe Arg Leu Phe Pro Phe Asp 
    130                 135                 140                 


Arg Gln Gln Phe Val Leu Glu Leu Glu Pro Phe Ser Tyr Asn Asn Gln 
145                 150                 155                 160 


Gln Leu Arg Phe Ser Asp Ile Gln Val Tyr Thr Glu Asn Ile Asp Asn 
                165                 170                 175     


Glu Glu Ile Asp Glu Trp Trp Ile Arg Gly Lys Ala Ser Thr His Ile 
            180                 185                 190         


Ser Asp Ile Arg Tyr Asp His Leu Ser Ser Val Gln Pro Asn Gln Asn 
        195                 200                 205             


Glu Phe Ser Arg Ile Thr Val Arg Ile Asp Ala Val Arg Gln Met Gly 
    210                 215                 220                 


Tyr Tyr Leu Ile Gln Met Tyr Ile Pro Ser Leu Leu Ile Val Ile Leu 
225                 230                 235                 240 


Ser Trp Ile Ser Phe Trp Ile Asn Met Asp Ala Ala Pro Ala Arg Val 
                245                 250                 255     


Gly Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Gln Ser Ser Gly 
            260                 265                 270         


Ser Arg Ala Ser Leu Pro Arg Leu Pro Tyr Thr Thr Val Ile Asp Ile 
        275                 280                 285             


Trp Met Ala Val Cys Leu Leu Phe Val Phe Ser Ala Leu Leu Glu Tyr 
    290                 295                 300                 


Ala Ala Val Asn Phe Val Ser Arg Ser Gln Pro Ala Arg Ala Ala Lys 
305                 310                 315                 320 


Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala Phe Leu Ile Phe 
                325                 330                 335     


Asn Met Phe Tyr Trp Ile Arg Gly Ile Thr Leu 
            340                 345         


<210>  11
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Chloride Channel Receptor

<400>  11

Met Gly Leu Arg Ala Leu Met Leu Trp Leu Leu Ala Ala Ala Gly Leu 
1               5                   10                  15      


Val Arg Glu Ser Leu Gln Ala Pro Ala Asp Asn Ala Ala Asp Ala Arg 
            20                  25                  30          


Pro Val Asp Val Ser Val Ser Ile Phe Ile Asn Lys Ile Tyr Gly Val 
        35                  40                  45              


Asn Thr Leu Glu Gln Thr Tyr Lys Val Asp Gly Tyr Ile Val Ala Gln 
    50                  55                  60                  


Trp Thr Gly Lys Pro Arg Lys Thr Pro Gly Asp Lys Pro Leu Ile Val 
65                  70                  75                  80  


Glu Asn Thr Gln Ile Glu Arg Trp Ile Asn Asn Gly Leu Trp Val Pro 
                85                  90                  95      


Ala Leu Glu Phe Ile Asn Val Val Gly Ser Pro Asp Thr Gly Asn Lys 
            100                 105                 110         


Arg Leu Met Leu Phe Pro Asp Gly Arg Val Ile Tyr Asn Ala Arg Phe 
        115                 120                 125             


Leu Gly Ser Phe Ser Asn Asp Met Asp Phe Arg Leu Phe Pro Phe Asp 
    130                 135                 140                 


Arg Gln Gln Phe Val Leu Glu Leu Glu Pro Phe Ser Tyr Asn Asn Gln 
145                 150                 155                 160 


Gln Leu Arg Phe Ser Asp Ile Gln Val Tyr Thr Glu Asn Ile Asp Asn 
                165                 170                 175     


Glu Glu Ile Asp Glu Trp Trp Ile Arg Gly Lys Ala Ser Thr His Ile 
            180                 185                 190         


Ser Asp Ile Arg Tyr Asp His Leu Ser Ser Val Gln Pro Asn Gln Asn 
        195                 200                 205             


Glu Phe Ser Arg Ile Thr Val Arg Ile Asp Ala Val Arg Asn Pro Ser 
    210                 215                 220                 


Tyr Tyr Leu Ile Gln Met Tyr Ile Pro Ser Leu Leu Ile Val Ile Leu 
225                 230                 235                 240 


Ser Trp Ile Ser Phe Trp Ile Asn Met Asp Ala Ala Pro Ala Arg Val 
                245                 250                 255     


Gly Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Gln Ser Ser Gly 
            260                 265                 270         


Ser Arg Ala Ser Leu Pro Arg Leu Pro Tyr Thr Thr Val Ile Asp Ile 
        275                 280                 285             


Trp Met Ala Val Cys Leu Leu Phe Val Phe Ser Ala Leu Leu Glu Tyr 
    290                 295                 300                 


Ala Ala Val Asn Phe Val Ser Arg Ser Gln Pro Ala Arg Ala Ala Lys 
305                 310                 315                 320 


Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala Phe Leu Ile Phe 
                325                 330                 335     


Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg Arg Glu Asp Val 
            340                 345                 350         


His Asn Gln 
        355 


<210>  12
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Chloride Channel Receptor

<400>  12

Met Gly Leu Arg Ala Leu Met Leu Trp Leu Leu Ala Ala Ala Gly Leu 
1               5                   10                  15      


Val Arg Glu Ser Leu Gln Ala Pro Ala Asp Asn Ala Ala Asp Ala Arg 
            20                  25                  30          


Pro Val Asp Val Ser Val Ser Ile Phe Ile Asn Lys Ile Tyr Gly Val 
        35                  40                  45              


Asn Thr Leu Glu Gln Thr Tyr Lys Val Asp Gly Tyr Ile Val Ala Gln 
    50                  55                  60                  


Trp Thr Gly Lys Pro Arg Lys Thr Pro Gly Asp Lys Pro Leu Ile Val 
65                  70                  75                  80  


Glu Asn Thr Gln Ile Glu Arg Trp Ile Asn Asn Gly Leu Trp Val Pro 
                85                  90                  95      


Ala Leu Glu Phe Ile Asn Val Val Gly Ser Pro Asp Thr Gly Asn Lys 
            100                 105                 110         


Arg Leu Met Leu Phe Pro Asp Gly Arg Val Ile Tyr Asn Ala Arg Phe 
        115                 120                 125             


Leu Gly Ser Phe Ser Asn Asp Met Asp Phe Arg Leu Phe Pro Phe Asp 
    130                 135                 140                 


Arg Gln Gln Phe Val Leu Glu Leu Glu Pro Phe Ser Tyr Asn Asn Gln 
145                 150                 155                 160 


Gln Leu Arg Phe Ser Asp Ile Gln Val Tyr Thr Glu Asn Ile Asp Asn 
                165                 170                 175     


Glu Glu Ile Asp Glu Trp Trp Ile Arg Gly Lys Ala Ser Thr His Ile 
            180                 185                 190         


Ser Asp Ile Arg Tyr Asp His Leu Ser Ser Val Gln Pro Asn Gln Asn 
        195                 200                 205             


Glu Phe Ser Arg Ile Thr Val Arg Ile Asp Ala Val Arg Gln Met Gly 
    210                 215                 220                 


Tyr Tyr Leu Ile Gln Met Tyr Ile Pro Ser Leu Leu Ile Val Ile Leu 
225                 230                 235                 240 


Ser Trp Ile Ser Phe Trp Ile Asn Met Asp Ala Ala Pro Ala Arg Val 
                245                 250                 255     


Gly Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Gln Ser Ser Gly 
            260                 265                 270         


Ser Arg Ala Ser Leu Pro Lys Val Ser Tyr Val Lys Ala Ile Asp Ile 
        275                 280                 285             


Trp Met Ala Val Cys Leu Leu Phe Val Phe Ser Ala Leu Leu Glu Tyr 
    290                 295                 300                 


Ala Ala Val Asn Phe Val Ser Arg Ser Gln Pro Ala Arg Ala Ala Lys 
305                 310                 315                 320 


Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala Phe Leu Ile Phe 
                325                 330                 335     


Asn Met Phe Tyr Trp Ile Arg Gly Ile Thr Leu 
            340                 345         


<210>  13
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Chloride Channel Receptor

<400>  13

Met Gly Leu Arg Ala Leu Met Leu Trp Leu Leu Ala Ala Ala Gly Leu 
1               5                   10                  15      


Val Arg Glu Ser Leu Gln Ala Pro Ala Asp Asn Ala Ala Asp Ala Arg 
            20                  25                  30          


Pro Val Asp Val Ser Val Ser Ile Phe Ile Asn Lys Ile Tyr Gly Val 
        35                  40                  45              


Asn Thr Leu Glu Gln Thr Tyr Lys Val Asp Gly Trp Ile Val Ala Gln 
    50                  55                  60                  


Trp Thr Gly Lys Pro Arg Lys Thr Pro Gly Asp Lys Pro Leu Ile Val 
65                  70                  75                  80  


Glu Asn Thr Gln Ile Glu Arg Trp Ile Asn Asn Gly Leu Trp Val Pro 
                85                  90                  95      


Ala Leu Glu Phe Tyr Asn Val Val Gly Ser Pro Asp Thr Gly Asn Lys 
            100                 105                 110         


Arg Leu Met Leu Phe Pro Asp Gly Arg Val Ile Tyr Asn Ala Arg Phe 
        115                 120                 125             


Leu Gly Ser Phe Ser Asn Asp Met Asp Phe Arg Leu Phe Pro Phe Asp 
    130                 135                 140                 


Arg Gln Gln Phe Val Leu Glu Leu Glu Pro Trp Ser Tyr Asn Asn Gln 
145                 150                 155                 160 


Gln Leu Arg Phe Ser Asp Ile Gln Val Tyr Thr Glu Asn Ile Asp Asn 
                165                 170                 175     


Glu Glu Ile Asp Glu Trp Trp Ile Arg Gly Lys Ala Ser Thr His Ile 
            180                 185                 190         


Ser Asp Ile Arg Tyr Asp His Leu Ser Ser Val Gln Pro Asn Gln Asn 
        195                 200                 205             


Glu Tyr Ser Arg Ile Thr Val Arg Ile Asp Ala Val Arg Gln Met Gly 
    210                 215                 220                 


Tyr Tyr Leu Ile Gln Met Tyr Ile Pro Ser Leu Leu Ile Val Ile Leu 
225                 230                 235                 240 


Ser Trp Ile Ser Phe Trp Ile Asn Met Asp Ala Ala Pro Ala Arg Val 
                245                 250                 255     


Gly Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Gln Ser Ser Gly 
            260                 265                 270         


Ser Arg Ala Ser Leu Pro Lys Val Ser Tyr Val Lys Ala Ile Asp Ile 
        275                 280                 285             


Trp Met Ala Val Cys Leu Leu Phe Val Phe Ser Ala Leu Leu Glu Tyr 
    290                 295                 300                 


Ala Ala Val Asn Phe Val Ser Arg Ser Gln Pro Ala Arg Ala Ala Lys 
305                 310                 315                 320 


Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala Phe Leu Ile Phe 
                325                 330                 335     


Asn Met Phe Tyr Trp Ile Arg Gly Ile Thr Leu 
            340                 345         


<210>  14
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Chloride Channel Receptor

<400>  14

Met Gly Leu Arg Ala Leu Met Leu Trp Leu Leu Ala Ala Ala Gly Leu 
1               5                   10                  15      


Val Arg Glu Ser Leu Gln Ala Pro Ala Asp Asn Ala Ala Asp Ala Arg 
            20                  25                  30          


Pro Val Asp Val Ser Val Ser Ile Phe Ile Asn Lys Ile Tyr Gly Ile 
        35                  40                  45              


Ala Glu Thr Thr Met Thr Tyr Lys Val Asp Gly Tyr Ile Val Ala Gln 
    50                  55                  60                  


Trp Thr Gly Lys Pro Arg Lys Thr Pro Gly Asp Lys Pro Leu Ile Val 
65                  70                  75                  80  


Glu Asn Thr Gln Ile Glu Arg Trp Ile Asn Asn Gly Leu Trp Val Pro 
                85                  90                  95      


Ala Leu Glu Phe Ile Asn Val Val Gly Ser Pro Asp Thr Gly Asn Lys 
            100                 105                 110         


Arg Leu Met Leu Phe Pro Asp Gly Arg Val Ile Tyr Asn Ala Arg Phe 
        115                 120                 125             


Leu Gly Ser Phe Ser Asn Asp Met Asp Leu Lys Asn Phe Pro Met Asp 
    130                 135                 140                 


Arg Gln Gln Phe Val Leu Glu Leu Glu Pro Phe Ser Tyr Asn Asn Gln 
145                 150                 155                 160 


Gln Leu Arg Phe Ser Asp Ile Gln Val Tyr Thr Glu Asn Ile Asp Gly 
                165                 170                 175     


Leu Thr Leu Pro Gln Phe Trp Ile Arg Gly Lys Ala Ser Thr His Ile 
            180                 185                 190         


Ser Asp Ile Arg Tyr Asp His Leu Ser Ser Val Gln Pro Asn Gln Asn 
        195                 200                 205             


Glu Phe Ser Arg Ile Thr Val Arg Ile Asp Ala Val Arg Gln Met Gly 
    210                 215                 220                 


Tyr Tyr Leu Ile Gln Met Tyr Ile Pro Ser Leu Leu Ile Val Ile Leu 
225                 230                 235                 240 


Ser Trp Ile Ser Phe Trp Ile Asn Met Asp Ala Ala Pro Ala Arg Val 
                245                 250                 255     


Gly Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Gln Ser Ser Gly 
            260                 265                 270         


Ser Arg Ala Ser Leu Pro Lys Val Ser Tyr Val Lys Ala Ile Asp Ile 
        275                 280                 285             


Trp Met Ala Val Cys Leu Leu Phe Val Phe Ser Ala Leu Leu Glu Tyr 
    290                 295                 300                 


Ala Ala Val Asn Phe Val Ser Arg Ser Gln Pro Ala Arg Ala Ala Lys 
305                 310                 315                 320 


Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala Phe Leu Ile Phe 
                325                 330                 335     


Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg Arg Glu Asp Val 
            340                 345                 350         


His Asn Gln 
        355 


<210>  15
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Chloride Channel Receptor

<400>  15

Met Gly Leu Arg Ala Leu Met Leu Trp Leu Leu Ala Ala Ala Gly Leu 
1               5                   10                  15      


Val Arg Glu Ser Leu Gln Ala Pro Ala Asp Asn Ala Ala Asp Ala Arg 
            20                  25                  30          


Pro Val Asp Val Ser Val Ser Ile Phe Ile Asn Lys Ile Tyr Gly Val 
        35                  40                  45              


Asn Thr Leu Glu Gln Thr Tyr Lys Val Asp Gly Tyr Ile Val Ala Gln 
    50                  55                  60                  


Trp Thr Gly Lys Pro Arg Lys Thr Pro Gly Asp Lys Pro Leu Ile Val 
65                  70                  75                  80  


Glu Asn Thr Gln Ile Glu Arg Trp Ile Asn Asn Gly Leu Trp Val Pro 
                85                  90                  95      


Ala Leu Glu Phe Ile Asn Val Val Gly Ser Pro Asp Thr Gly Asn Lys 
            100                 105                 110         


Ala Leu Met Leu Phe Pro Asp Gly Arg Val Ile Tyr Asn Ala Arg Phe 
        115                 120                 125             


Leu Gly Ser Phe Ser Asn Asp Met Asp Phe Arg Leu Phe Pro Phe Asp 
    130                 135                 140                 


Arg Gln Gln Phe Val Leu Glu Leu Glu Pro Phe Ser Tyr Asn Asn Gln 
145                 150                 155                 160 


Gln Leu Arg Phe Ser Asp Ile Gln Val Tyr Thr Glu Asn Ile Asp Asn 
                165                 170                 175     


Glu Glu Ile Asp Glu Trp Trp Ile Arg Gly Lys Ala Ser Thr His Ile 
            180                 185                 190         


Ser Asp Ile Arg Tyr Asp His Leu Ser Ser Val Gln Pro Asn Gln Asn 
        195                 200                 205             


Glu Tyr Ser Arg Ile Thr Val Arg Ile Asp Ala Val Arg Gln Met Gly 
    210                 215                 220                 


Tyr Tyr Leu Ile Gln Met Tyr Ile Pro Ser Leu Leu Ile Val Ile Leu 
225                 230                 235                 240 


Ser Trp Ile Ser Phe Trp Ile Asn Met Asp Ala Ala Pro Ala Arg Val 
                245                 250                 255     


Gly Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Gln Ser Ser Gly 
            260                 265                 270         


Ser Arg Ala Ser Leu Pro Lys Val Ser Tyr Val Lys Ala Ile Asp Ile 
        275                 280                 285             


Trp Met Ala Val Cys Leu Leu Phe Val Phe Ser Ala Leu Leu Glu Tyr 
    290                 295                 300                 


Ala Ala Val Asn Phe Val Ser Arg Ser Gln Pro Ala Arg Ala Ala Lys 
305                 310                 315                 320 


Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala Phe Leu Ile Phe 
                325                 330                 335     


Asn Met Phe Tyr Trp Ile Arg Gly Ile Thr Leu 
            340                 345         


<210>  16
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys 
1               5                   10                  15      


Glu Asp Glu Ala Gly Glu Gly Arg Phe Asn Phe Ser Ala Tyr Gly Met 
            20                  25                  30          


Gly Pro Ala Cys Leu Gln Ala Lys Asp Gly Ile Ser Val Lys Gly Ala 
        35                  40                  45              


Asn Asn Ser Asn Thr Thr Asn Pro Pro Pro Ala Pro Ser Lys Ser Pro 
    50                  55                  60                  


Glu Glu Met Arg Lys Leu Phe Ile Gln Arg Ala Lys 
65                  70                  75      


<210>  17
<211>  7
<212>  PRT
<213>  Gloeobacter violaceus

<400>  17

Ser Gln Pro Ala Arg Ala Ala 
1               5           


<210>  18
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  18

Lys Ile Val Arg Arg Glu Asp Val His Asn Gln 
1               5                   10      


<210>  19
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  19

Ile Tyr Lys Ile Val Arg Arg Glu Asp Val His Asn Gln 
1               5                   10              


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C terminal sequence

<400>  20

Arg Gly Ile Thr Leu 
1               5   


<210>  21
<211>  4
<212>  PRT
<213>  Gloeobacter violaceus

<400>  21

Arg Ile Ser Arg 
1               


<210>  22
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Met Gly Tyr 
1               


<210>  23
<211>  4
<212>  PRT
<213>  Erwinia chrysanthemi

<400>  23

Val Arg Ile Asp 
1               


<210>  24
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  24

Tyr Leu Ile Gln 
1               


<210>  25
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  25

Thr Gln Ser Ser Gly Ser Arg 
1               5           


<210>  26
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  26

Tyr Tyr Leu Ile Gln Met Tyr Ile Pro Ser Leu Leu Ile Val Ile Leu 
1               5                   10                  15      


Ser Trp Ile Ser Phe Trp Ile Asn Met Asp Ala Ala Pro Ala Arg Val 
            20                  25                  30          


Gly Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Gln Ser Ser Gly 
        35                  40                  45              


Ser Arg Ala Ser Leu Pro Lys Val Ser Tyr Val Lys Ala Ile Asp Ile 
    50                  55                  60                  


Trp Met Ala Val Cys Leu Leu Phe Val Phe Ser Ala Leu Leu Glu Tyr 
65                  70                  75                  80  


Ala Ala Val Asn Phe Val Ser Arg 
                85              


<210>  27
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  27

Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala Phe Leu Ile 
1               5                   10                  15      


Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg Arg Glu Asp 
            20                  25                  30          


Val His Asn Gln 
        35      


<210>  28
<211>  192
<212>  PRT
<213>  Gloeobacter violaceus

<400>  28

Gly Gln Asp Met Val Ser Pro Pro Pro Pro Ile Ala Asp Glu Pro Leu 
1               5                   10                  15      


Thr Val Asn Thr Gly Ile Tyr Leu Ile Glu Cys Tyr Ser Leu Asp Asp 
            20                  25                  30          


Lys Ala Glu Thr Phe Lys Val Asn Ala Phe Leu Ser Leu Ser Trp Lys 
        35                  40                  45              


Asp Arg Arg Leu Ala Phe Asp Pro Val Arg Ser Gly Val Arg Val Lys 
    50                  55                  60                  


Thr Tyr Glu Pro Glu Ala Ile Trp Ile Pro Glu Ile Arg Phe Val Asn 
65                  70                  75                  80  


Val Glu Asn Ala Arg Asp Ala Asp Val Val Asp Ile Ser Val Ser Pro 
                85                  90                  95      


Asp Gly Thr Val Gln Tyr Leu Glu Arg Phe Ser Ala Arg Val Leu Ser 
            100                 105                 110         


Pro Leu Asp Phe Arg Arg Tyr Pro Phe Asp Ser Gln Thr Leu His Ile 
        115                 120                 125             


Tyr Leu Ile Val Arg Ser Val Asp Thr Arg Asn Ile Val Leu Ala Val 
    130                 135                 140                 


Asp Leu Glu Lys Val Gly Lys Asn Asp Asp Val Phe Leu Thr Gly Trp 
145                 150                 155                 160 


Asp Ile Glu Ser Phe Thr Ala Val Val Lys Pro Ala Asn Phe Ala Leu 
                165                 170                 175     


Glu Asp Arg Leu Glu Ser Lys Leu Asp Tyr Gln Leu Arg Ile Ser Arg 
            180                 185                 190         


<210>  29
<211>  199
<212>  PRT
<213>  Erwinia chrysanthemi

<400>  29

Ala Pro Ala Asp Asn Ala Ala Asp Ala Arg Pro Val Asp Val Ser Val 
1               5                   10                  15      


Ser Ile Phe Ile Asn Lys Ile Tyr Gly Val Asn Thr Leu Glu Gln Thr 
            20                  25                  30          


Tyr Lys Val Asp Gly Tyr Ile Val Ala Gln Trp Thr Gly Lys Pro Arg 
        35                  40                  45              


Lys Thr Pro Gly Asp Lys Pro Leu Ile Val Glu Asn Thr Gln Ile Glu 
    50                  55                  60                  


Arg Trp Ile Asn Asn Gly Leu Trp Val Pro Ala Leu Glu Phe Ile Asn 
65                  70                  75                  80  


Val Val Gly Ser Pro Asp Thr Gly Asn Lys Arg Leu Met Leu Phe Pro 
                85                  90                  95      


Asp Gly Arg Val Ile Tyr Asn Ala Arg Phe Leu Gly Ser Phe Ser Asn 
            100                 105                 110         


Asp Met Asp Phe Arg Leu Phe Pro Phe Asp Arg Gln Gln Phe Val Leu 
        115                 120                 125             


Glu Leu Glu Pro Phe Ser Tyr Asn Asn Gln Gln Leu Arg Phe Ser Asp 
    130                 135                 140                 


Ile Gln Val Tyr Thr Glu Asn Ile Asp Asn Glu Glu Ile Asp Glu Trp 
145                 150                 155                 160 


Trp Ile Arg Gly Lys Ala Ser Thr His Ile Ser Asp Ile Arg Tyr Asp 
                165                 170                 175     


His Leu Ser Ser Val Gln Pro Asn Gln Asn Glu Phe Ser Arg Ile Thr 
            180                 185                 190         


Val Arg Ile Asp Ala Val Arg 
        195                 


<210>  30
<211>  6
<212>  PRT
<213>  Gloeobacter violaceus

<400>  30

Leu Asp Asp Lys Ala Glu 
1               5       


<210>  31
<211>  6
<212>  PRT
<213>  Erwinia chrysanthemi

<400>  31

Val Asn Thr Leu Glu Gln 
1               5       


<210>  32
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  32

Ile Ala Glu Thr Thr Met 
1               5       


<210>  33
<211>  15
<212>  PRT
<213>  Gloeobacter violaceus

<400>  33

Ser Pro Leu Asp Phe Arg Arg Tyr Pro Phe Asp Ser Gln Thr Leu 
1               5                   10                  15  


<210>  34
<211>  15
<212>  PRT
<213>  Erwinia chrysanthemi

<400>  34

Asn Asp Met Asp Phe Arg Leu Phe Pro Phe Asp Arg Gln Gln Phe 
1               5                   10                  15  


<210>  35
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  35

Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp Val Gln Thr Cys 
1               5                   10                  15  


<210>  36
<211>  9
<212>  PRT
<213>  Gloeobacter violaceus

<400>  36

Gly Lys Asn Asp Asp Val Phe Leu Thr 
1               5                   


<210>  37
<211>  11
<212>  PRT
<213>  Erwinia chrysanthemi

<400>  37

Asp Asn Glu Glu Ile Asp Glu Trp Trp Ile Arg 
1               5                   10      


<210>  38
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  38

Ala Val Gln Val Ala Asp Gly Leu Thr Leu Pro 
1               5                   10      


<210>  39
<211>  9
<212>  PRT
<213>  Gloeobacter violaceus

<400>  39

Gln Leu Arg Ile Ser Arg Gln Tyr Phe 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Erwinia chrysanthemi

<400>  40

Arg Ile Asp Ala Val Arg Asn Pro Ser 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  41

Arg Phe His Leu Glu Arg Gln Met Gly 
1               5                   


<210>  42
<211>  8
<212>  PRT
<213>  Gloeobacter violaceus

<400>  42

Leu Pro Lys Thr Pro Tyr Met Thr 
1               5               


<210>  43
<211>  8
<212>  PRT
<213>  Erwinia chrysanthemi

<400>  43

Leu Pro Arg Leu Pro Tyr Thr Thr 
1               5               


<210>  44
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  44

Leu Pro Lys Val Ser Tyr Val Lys 
1               5               


<210>  45
<211>  5
<212>  PRT
<213>  Gloeobacter violaceus

<400>  45

Ile Tyr Phe Gly Phe 
1               5   


<210>  46
<211>  5
<212>  PRT
<213>  Erwinia chrysanthemi

<400>  46

Arg Gly Ile Thr Leu 
1               5   


<210>  47
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  47

Ile Tyr Lys Ile Val Arg Arg Glu Asp Val His Asn Gln 
1               5                   10              


<210>  48
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  48

His His Arg Gln Ala Asn Gly Val Glu Asp Asp 
1               5                   10      


<210>  49
<211>  5
<212>  PRT
<213>  Erwinia chrysanthemi

<400>  49

Gly Gly Gly Gly Gly 
1               5   


<210>  50
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  50

Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Gln Ser 
1               5                   10                  15      


Ser Gly Ser Arg 
            20  


<210>  51
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  51

Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr 
1               5                   10                  15      


Gln Ser Ser Gly 
            20  


<210>  52
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered Chloride Channel Receptor


<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa can be W or Y

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  Xaa can be W or Y

<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  Xaa can be D, E, S, T, N, Q, C, U, G, P, A, V, I, L, M, F, Y, W, H

<220>
<221>  misc_feature
<222>  (155)..(155)
<223>  Xaa can be W or Y

<220>
<221>  misc_feature
<222>  (210)..(210)
<223>  Xaa can be W or Y

<220>
<221>  misc_feature
<222>  (268)..(268)
<223>  Xaa can be N, Q, S, T, Y, D, E, R, H, K

<220>
<221>  misc_feature
<222>  (271)..(271)
<223>  Xaa can be any naturally occurring amino acid

<400>  52

Met Gly Leu Arg Ala Leu Met Leu Trp Leu Leu Ala Ala Ala Gly Leu 
1               5                   10                  15      


Val Arg Glu Ser Leu Gln Ala Pro Ala Asp Asn Ala Ala Asp Ala Arg 
            20                  25                  30          


Pro Val Asp Val Ser Val Ser Ile Phe Ile Asn Lys Ile Tyr Gly Val 
        35                  40                  45              


Asn Thr Leu Glu Gln Thr Tyr Lys Val Asp Gly Xaa Ile Val Ala Gln 
    50                  55                  60                  


Trp Thr Gly Lys Pro Arg Lys Thr Pro Gly Asp Lys Pro Leu Ile Val 
65                  70                  75                  80  


Glu Asn Thr Gln Ile Glu Arg Trp Ile Asn Asn Gly Leu Trp Val Pro 
                85                  90                  95      


Ala Leu Glu Phe Xaa Asn Val Val Gly Ser Pro Asp Thr Gly Asn Lys 
            100                 105                 110         


Xaa Leu Met Leu Phe Pro Asp Gly Arg Val Ile Tyr Asn Ala Arg Phe 
        115                 120                 125             


Leu Gly Ser Phe Ser Asn Asp Met Asp Phe Arg Leu Phe Pro Phe Asp 
    130                 135                 140                 


Arg Gln Gln Phe Val Leu Glu Leu Glu Pro Xaa Ser Tyr Asn Asn Gln 
145                 150                 155                 160 


Gln Leu Arg Phe Ser Asp Ile Gln Val Tyr Thr Glu Asn Ile Asp Asn 
                165                 170                 175     


Glu Glu Ile Asp Glu Trp Trp Ile Arg Gly Lys Ala Ser Thr His Ile 
            180                 185                 190         


Ser Asp Ile Arg Tyr Asp His Leu Ser Ser Val Gln Pro Asn Gln Asn 
        195                 200                 205             


Glu Xaa Ser Arg Ile Thr Val Arg Ile Asp Ala Val Arg Gln Met Gly 
    210                 215                 220                 


Tyr Tyr Leu Ile Gln Met Tyr Ile Pro Ser Leu Leu Ile Val Ile Leu 
225                 230                 235                 240 


Ser Trp Ile Ser Phe Trp Ile Asn Met Asp Ala Ala Pro Ala Arg Val 
                245                 250                 255     


Gly Leu Gly Ile Thr Thr Val Leu Thr Met Thr Xaa Gln Ser Xaa Gly 
            260                 265                 270         


Ser Arg Ala Ser Leu Pro Lys Val Ser Tyr Val Lys Ala Ile Asp Ile 
        275                 280                 285             


Trp Met Ala Val Cys Leu Leu Phe Val Phe Ser Ala Leu Leu Glu Tyr 
    290                 295                 300                 


Ala Ala Val Asn Phe Val Ser Arg Ser Gln Pro Ala Arg Ala Ala Lys 
305                 310                 315                 320 


Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala Phe Leu Ile Phe 
                325                 330                 335     


Asn Met Phe Tyr Trp Ile Arg Gly Ile Thr Leu 
            340                 345         


<210>  53
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Homing Peptide

<400>  53

Asn Thr Gln Thr Leu Ala Lys Ala Pro Glu His Thr 
1               5                   10          


<210>  54
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Homing Peptide

<400>  54

His Leu Asn Ile Leu Ser Thr Leu Trp Lys Tyr Arg 
1               5                   10          


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Homing Peptide

<400>  55

Arg Pro Pro Gly Phe Ser Pro Phe 
1               5               


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Homing Peptide

<400>  56

Lys Pro Pro Gly Phe Ser Pro Phe 
1               5               


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Homing Peptide

<400>  57

Lys Arg Pro Pro Gly Phe Ser Pro Phe 
1               5                   


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Homing Peptide

<400>  58

Lys Lys Pro Pro Gly Phe Ser Pro Phe 
1               5                   


<210>  59
<211>  4
<212>  PRT
<213>  Erwinia chrysanthemi

<400>  59

Arg Asn Pro Ser 
1               


<210>  60
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  60

Arg Gln Met Gly 
1               


<210>  61
<211>  12
<212>  PRT
<213>  Erwinia chrysanthemi

<400>  61

Asn Gly Leu Trp Val Pro Ala Leu Glu Phe Ile Asn 
1               5                   10          


<210>  62
<211>  12
<212>  PRT
<213>  Gloeobacter violaceus

<400>  62

Glu Ala Ile Trp Ile Pro Glu Ile Arg Phe Val Asn 
1               5                   10          


<210>  63
<211>  5
<212>  PRT
<213>  Erwinia chrysanthemi

<400>  63

Phe Ser Tyr Asn Asn 
1               5   


<210>  64
<211>  5
<212>  PRT
<213>  Gloeobacter violaceus

<400>  64

Arg Ser Val Asp Thr 
1               5   


<210>  65
<211>  12
<212>  PRT
<213>  Erwinia chrysanthemi

<400>  65

Tyr Asp His Leu Ser Ser Val Gln Pro Asn Gln Asn 
1               5                   10          


<210>  66
<211>  8
<212>  PRT
<213>  Gloeobacter violaceus

<400>  66

Phe Ala Leu Glu Asp Arg Leu Glu 
1               5               


<210>  67
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  67

Tyr Leu Ile Gln Met Tyr Ile Pro Ser Leu Leu Ile Val Ile Leu Ser 
1               5                   10                  15      


Trp Ile Ser Phe Trp Ile Asn 
            20              


<210>  68
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  68

Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val Phe Ser Ala 
1               5                   10                  15      


Leu Leu Glu Tyr Ala Ala Val Asn Phe 
            20                  25  


<210>  69
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  69

Lys Ile Ser Arg Ile Gly Phe Pro Met Ala Phe Leu Ile Phe Asn Met 
1               5                   10                  15      


Phe Tyr Trp Ile Ile Tyr Lys Ile 
            20                  


<210>  70
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Tyr Ser Phe Asn Thr Leu Arg Leu Tyr Leu Trp Glu Thr Ile Val 
1               5                   10                  15      


Phe Phe Ser Leu Ala Ala Ser Lys Glu Ala Glu Ala Ala Arg Ser Ala 
            20                  25                  30          


Pro Lys Pro Met Ser Pro Ser Asp Phe Leu Asp Lys Leu Met Gly Arg 
        35                  40                  45              


Thr Ser Gly Tyr Asp Ala Arg Ile Arg Pro Asn Phe Lys Gly Pro Pro 
    50                  55                  60                  


Val Asn Val Ser Cys Asn Ile Phe Ile Asn Ser Phe Gly Ser Ile Ala 
65                  70                  75                  80  


Glu Thr Thr Met Asp Tyr Arg Val Asn Ile Phe Leu Arg Gln Gln Trp 
                85                  90                  95      


Asn Asp Pro Arg Leu Ala Tyr Asn Glu Tyr Pro Asp Asp Ser Leu Asp 
            100                 105                 110         


Leu Asp Pro Ser Met Leu Asp Ser Ile Trp Lys Pro Asp Leu Phe Phe 
        115                 120                 125             


Ala Asn Glu Lys Gly Ala His Phe His Glu Ile Thr Thr Asp Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Ser Arg Asn Gly Asn Val Leu Tyr Ser Ile Arg Ile 
145                 150                 155                 160 


Thr Leu Thr Leu Ala Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
                165                 170                 175     


Val Gln Thr Cys Ile Met Gln Leu Glu Ser Phe Gly Tyr Thr Met Asn 
            180                 185                 190         


Asp Leu Ile Phe Glu Trp Gln Glu Gln Gly Ala Val Gln Val Ala Asp 
        195                 200                 205             


Gly Leu Thr Leu Pro Gln Phe Ile Leu Lys Glu Glu Lys Asp Leu Arg 
    210                 215                 220                 


Tyr Cys Thr Lys His Tyr Asn Thr Gly Lys Phe Thr Cys Ile Glu Ala 
225                 230                 235                 240 


Arg Phe His Leu Glu Arg Gln Met Gly Tyr Tyr Leu Ile Gln Met Tyr 
                245                 250                 255     


Ile Pro Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile 
            260                 265                 270         


Asn Met Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val 
        275                 280                 285             


Leu Thr Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys 
    290                 295                 300                 


Val Ser Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu 
305                 310                 315                 320 


Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser 
                325                 330                 335     


Arg Gln His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His 
            340                 345                 350         


Lys Ser Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly 
        355                 360                 365             


Arg Phe Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala 
    370                 375                 380                 


Lys Asp Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn 
385                 390                 395                 400 


Pro Pro Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe 
                405                 410                 415     


Ile Gln Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro 
            420                 425                 430         


Met Ala Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile 
        435                 440                 445             


Val Arg Arg Glu Asp Val His Asn Gln 
    450                 455         


