                         SEQUENCE LISTING

<110>  MERCK SHARP & DOHME CORP.
       Kashi, Ramesh
       Badkar, Aniket
 
<120>  Solution Formulations of Engineered Anti-IL-23p19 Antibodies

<130>  23364

<150>  US 61/737,035
<151>  2012-12-13

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human frameworks, rodent CDRs


<220>
<221>  DOMAIN
<222>  (1)..(116)
<223>  Variable Domain

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ile Thr Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Ser Gly Ser Ala Asp Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  2
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human frameworks, rodent CDRs


<220>
<221>  DOMAIN
<222>  (1)..(108)
<223>  Variable Domain

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Ile Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  3
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  3

Gly Tyr Ile Phe Ile Thr Tyr Trp Met Thr 
1               5                   10  


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rodent CDR with one amino acid substitution

<400>  4

Gln Ile Phe Pro Ala Ser Gly Ser Ala Asp Tyr Asn Glu Lys Phe Glu 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  5

Gly Gly Gly Gly Phe Ala Tyr 
1               5           


<210>  6
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  6

Arg Thr Ser Glu Asn Ile Tyr Ser Tyr Leu Ala 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  7

Asn Ala Lys Thr Leu Ala Glu 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  8

Gln His His Tyr Gly Ile Pro Phe Thr 
1               5                   


<210>  9
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  9

Arg Ala Val Pro Gly Gly Ser Ser Pro Ala Trp Thr Gln Cys Gln Gln 
1               5                   10                  15      


Leu Ser Gln Lys Leu Cys Thr Leu Ala Trp Ser Ala His Pro Leu Val 
            20                  25                  30          


Gly His Met Asp Leu Arg Glu Glu Gly Asp Glu Glu Thr Thr Asn Asp 
        35                  40                  45              


Val Pro His Ile Gln Cys Gly Asp Gly Cys Asp Pro Gln Gly Leu Arg 
    50                  55                  60                  


Asp Asn Ser Gln Phe Cys Leu Gln Arg Ile His Gln Gly Leu Ile Phe 
65                  70                  75                  80  


Tyr Glu Lys Leu Leu Gly Ser Asp Ile Phe Thr Gly Glu Pro Ser Leu 
                85                  90                  95      


Leu Pro Asp Ser Pro Val Gly Gln Leu His Ala Ser Leu Leu Gly Leu 
            100                 105                 110         


Ser Gln Leu Leu Gln Pro Glu Gly His His Trp Glu Thr Gln Gln Ile 
        115                 120                 125             


Pro Ser Leu Ser Pro Ser Gln Pro Trp Gln Arg Leu Leu Leu Arg Phe 
    130                 135                 140                 


Lys Ile Leu Arg Ser Leu Gln Ala Phe Val Ala Val Ala Ala Arg Val 
145                 150                 155                 160 


Phe Ala His Gly Ala Ala Thr Leu Ser Pro 
                165                 170 


<210>  10
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human constant and framework regions, rodent CDRs

<400>  10
atggctgtgc tggggctgct gttctgcctg gtgacattcc caagctgtgt gctgtcccag       60

gtgcagctgg tgcagtctgg cgctgaggtg aagaagcctg gcgcctccgt gaaggtctcc      120

tgcaaggctt ctggctacat cttcatcacc tactggatga cctgggtgcg gcaggcccct      180

ggccaggggc tggagtggat gggccagatc ttccctgcca gcggctctgc agactacaac      240

gagaagttcg aaggcagagt caccatgacc acagacacat ccaccagcac agcctacatg      300

gagctgagga gcctgagatc tgacgacacc gccgtgtatt actgtgccag aggcggtggc      360

ggattcgctt actggggcca gggcaccctg gtcaccgtct ccagcgctag caccaagggc      420

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      480

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      540

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      600

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      660

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa      720

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      780

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      840

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      900

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      960

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1020

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1080

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1140

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1200

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1260

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1320

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1380

ctgtctccgg gtaaatga                                                   1398


<210>  11
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human constant and framework regions, rodent CDRs

<400>  11
atggctccag tgcagctgct ggggctgctg gtgctgttcc tgccagccat gagatgtgat       60

atccagatga cccagtctcc atcctccctg tctgcctctg tgggcgacag agtgaccatc      120

acctgcagga ccagcgagaa catctacagc tacctggcct ggtatcagca gaagccaggg      180

aaggccccta agctgctgat ctataacgcc aagaccctgg ctgaaggggt gccatccagg      240

ttcagcggca gcggctctgg gacagacttc accctgacca tcagcagcct gcagcctgag      300

gacttcgcca cctactactg tcagcaccac tacggaattc cattcacctt cggccagggc      360

accaaggtgg agatcaagcg tacggtggct gcaccatctg tgttcatctt ccctccatct      420

gatgagcagc tgaagtctgg aactgcctcc gtggtgtgcc tgctgaataa cttctatccc      480

agagaggcca aggtgcagtg gaaggtggat aacgccctcc agagcggcaa ctcccaggag      540

agcgtgacag agcaggacag caaggacagc acctacagcc tgagcagcac cctgaccctg      600

agcaaagcag actacgagaa acacaaggtg tacgcctgcg aggtgaccca tcagggcctg      660

agcagccccg tgacaaagag cttcaacagg ggagagtgtt aa                         702


<210>  12
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  12

Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser 
            


<210>  13
<211>  19
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Met Ala Pro Val Gln Leu Leu Gly Leu Leu Val Leu Phe Leu Pro Ala 
1               5                   10                  15      


Met Arg Cys 
            


