                               SEQUENCE LISTING

<110> CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> METHODS AND ASSAYS FOR COMBINATION TREATMENT OF CANCER

<130> 701039-073361-PCT

<140>
<141>

<150> 61/735,303
<151> 2012-12-10

<160> 38    

<170> PatentIn version 3.5

<210> 1
<211> 751
<212> PRT
<213> Homo sapiens

<400> 1
Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile 
                85                  90                  95      


Pro Leu Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser 
            100                 105                 110         


Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val Leu 
        115                 120                 125             


His Asn Ile Pro Tyr Met Gly Asp Glu Val Leu Asp Gln Asp Gly Thr 
    130                 135                 140                 


Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp Gly Lys Val His Gly Asp 
145                 150                 155                 160 


Arg Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn 
                165                 170                 175     


Ala Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp 
            180                 185                 190         


Pro Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp 
        195                 200                 205             


Asp Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe 
    210                 215                 220                 


Glu Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu 
225                 230                 235                 240 


Lys Glu Lys Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu 
                245                 250                 255     


Pro Pro Glu Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val 
            260                 265                 270         


Gln Arg Glu Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg 
        275                 280                 285             


Cys Phe Lys Tyr Asp Cys Phe Leu His Arg Lys Cys Asn Tyr Ser Phe 
    290                 295                 300                 


His Ala Thr Pro Asn Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala Leu 
305                 310                 315                 320 


Asp Asn Lys Pro Cys Gly Pro Gln Cys Tyr Gln His Leu Glu Gly Ala 
                325                 330                 335     


Lys Glu Phe Ala Ala Ala Leu Thr Ala Glu Arg Ile Lys Thr Pro Pro 
            340                 345                 350         


Lys Arg Pro Gly Gly Arg Arg Arg Gly Arg Leu Pro Asn Asn Ser Ser 
        355                 360                 365             


Arg Pro Ser Thr Pro Thr Ile Asn Val Leu Glu Ser Lys Asp Thr Asp 
    370                 375                 380                 


Ser Asp Arg Glu Ala Gly Thr Glu Thr Gly Gly Glu Asn Asn Asp Lys 
385                 390                 395                 400 


Glu Glu Glu Glu Lys Lys Asp Glu Thr Ser Ser Ser Ser Glu Ala Asn 
                405                 410                 415     


Ser Arg Cys Gln Thr Pro Ile Lys Met Lys Pro Asn Ile Glu Pro Pro 
            420                 425                 430         


Glu Asn Val Glu Trp Ser Gly Ala Glu Ala Ser Met Phe Arg Val Leu 
        435                 440                 445             


Ile Gly Thr Tyr Tyr Asp Asn Phe Cys Ala Ile Ala Arg Leu Ile Gly 
    450                 455                 460                 


Thr Lys Thr Cys Arg Gln Val Tyr Glu Phe Arg Val Lys Glu Ser Ser 
465                 470                 475                 480 


Ile Ile Ala Pro Ala Pro Ala Glu Asp Val Asp Thr Pro Pro Arg Lys 
                485                 490                 495     


Lys Lys Arg Lys His Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln 
            500                 505                 510         


Leu Lys Lys Asp Gly Ser Ser Asn His Val Tyr Asn Tyr Gln Pro Cys 
        515                 520                 525             


Asp His Pro Arg Gln Pro Cys Asp Ser Ser Cys Pro Cys Val Ile Ala 
    530                 535                 540                 


Gln Asn Phe Cys Glu Lys Phe Cys Gln Cys Ser Ser Glu Cys Gln Asn 
545                 550                 555                 560 


Arg Phe Pro Gly Cys Arg Cys Lys Ala Gln Cys Asn Thr Lys Gln Cys 
                565                 570                 575     


Pro Cys Tyr Leu Ala Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr 
            580                 585                 590         


Cys Gly Ala Ala Asp His Trp Asp Ser Lys Asn Val Ser Cys Lys Asn 
        595                 600                 605             


Cys Ser Ile Gln Arg Gly Ser Lys Lys His Leu Leu Leu Ala Pro Ser 
    610                 615                 620                 


Asp Val Ala Gly Trp Gly Ile Phe Ile Lys Asp Pro Val Gln Lys Asn 
625                 630                 635                 640 


Glu Phe Ile Ser Glu Tyr Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala 
                645                 650                 655     


Asp Arg Arg Gly Lys Val Tyr Asp Lys Tyr Met Cys Ser Phe Leu Phe 
            660                 665                 670         


Asn Leu Asn Asn Asp Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys 
        675                 680                 685             


Ile Arg Phe Ala Asn His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val 
    690                 695                 700                 


Met Met Val Asn Gly Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala 
705                 710                 715                 720 


Ile Gln Thr Gly Glu Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala 
                725                 730                 735     


Asp Ala Leu Lys Tyr Val Gly Ile Glu Arg Glu Met Glu Ile Pro 
            740                 745                 750     


<210> 2
<211> 2723
<212> DNA
<213> Homo sapiens

<400> 2
ggcggcgctt gattgggctg ggggggccaa ataaaagcga tggcgattgg gctgccgcgt       60

ttggcgctcg gtccggtcgc gtccgacacc cggtgggact cagaaggcag tggagccccg      120

gcggcggcgg cggcggcgcg cgggggcgac gcgcgggaac aacgcgagtc ggcgcgcggg      180

acgaagaata atcatgggcc agactgggaa gaaatctgag aagggaccag tttgttggcg      240

gaagcgtgta aaatcagagt acatgcgact gagacagctc aagaggttca gacgagctga      300

tgaagtaaag agtatgttta gttccaatcg tcagaaaatt ttggaaagaa cggaaatctt      360

aaaccaagaa tggaaacagc gaaggataca gcctgtgcac atcctgactt ctgtgagctc      420

attgcgcggg actagggagt gttcggtgac cagtgacttg gattttccaa cacaagtcat      480

cccattaaag actctgaatg cagttgcttc agtacccata atgtattctt ggtctcccct      540

acagcagaat tttatggtgg aagatgaaac tgttttacat aacattcctt atatgggaga      600

tgaagtttta gatcaggatg gtactttcat tgaagaacta ataaaaaatt atgatgggaa      660

agtacacggg gatagagaat gtgggtttat aaatgatgaa atttttgtgg agttggtgaa      720

tgcccttggt caatataatg atgatgacga tgatgatgat ggagacgatc ctgaagaaag      780

agaagaaaag cagaaagatc tggaggatca ccgagatgat aaagaaagcc gcccacctcg      840

gaaatttcct tctgataaaa tttttgaagc catttcctca atgtttccag ataagggcac      900

agcagaagaa ctaaaggaaa aatataaaga actcaccgaa cagcagctcc caggcgcact      960

tcctcctgaa tgtaccccca acatagatgg accaaatgct aaatctgttc agagagagca     1020

aagcttacac tcctttcata cgcttttctg taggcgatgt tttaaatatg actgcttcct     1080

acatcgtaag tgcaattatt cttttcatgc aacacccaac acttataagc ggaagaacac     1140

agaaacagct ctagacaaca aaccttgtgg accacagtgt taccagcatt tggagggagc     1200

aaaggagttt gctgctgctc tcaccgctga gcggataaag accccaccaa aacgtccagg     1260

aggccgcaga agaggacggc ttcccaataa cagtagcagg cccagcaccc ccaccattaa     1320

tgtgctggaa tcaaaggata cagacagtga tagggaagca gggactgaaa cggggggaga     1380

gaacaatgat aaagaagaag aagagaagaa agatgaaact tcgagctcct ctgaagcaaa     1440

ttctcggtgt caaacaccaa taaagatgaa gccaaatatt gaacctcctg agaatgtgga     1500

gtggagtggt gctgaagcct caatgtttag agtcctcatt ggcacttact atgacaattt     1560

ctgtgccatt gctaggttaa ttgggaccaa aacatgtaga caggtgtatg agtttagagt     1620

caaagaatct agcatcatag ctccagctcc cgctgaggat gtggatactc ctccaaggaa     1680

aaagaagagg aaacaccggt tgtgggctgc acactgcaga aagatacagc tgaaaaagga     1740

cggctcctct aaccatgttt acaactatca accctgtgat catccacggc agccttgtga     1800

cagttcgtgc ccttgtgtga tagcacaaaa tttttgtgaa aagttttgtc aatgtagttc     1860

agagtgtcaa aaccgctttc cgggatgccg ctgcaaagca cagtgcaaca ccaagcagtg     1920

cccgtgctac ctggctgtcc gagagtgtga ccctgacctc tgtcttactt gtggagccgc     1980

tgaccattgg gacagtaaaa atgtgtcctg caagaactgc agtattcagc ggggctccaa     2040

aaagcatcta ttgctggcac catctgacgt ggcaggctgg gggattttta tcaaagatcc     2100

tgtgcagaaa aatgaattca tctcagaata ctgtggagag attatttctc aagatgaagc     2160

tgacagaaga gggaaagtgt atgataaata catgtgcagc tttctgttca acttgaacaa     2220

tgattttgtg gtggatgcaa cccgcaaggg taacaaaatt cgttttgcaa atcattcggt     2280

aaatccaaac tgctatgcaa aagttatgat ggttaacggt gatcacagga taggtatttt     2340

tgccaagaga gccatccaga ctggcgaaga gctgtttttt gattacagat acagccaggc     2400

tgatgccctg aagtatgtcg gcatcgaaag agaaatggaa atcccttgac atctgctacc     2460

tcctcccccc tcctctgaaa cagctgcctt agcttcagga acctcgagta ctgtgggcaa     2520

tttagaaaaa gaacatgcag tttgaaattc tgaatttgca aagtactgta agaataattt     2580

atagtaatga gtttaaaaat caacttttta ttgccttctc accagctgca aagtgttttg     2640

taccagtgaa tttttgcaat aatgcagtat ggtacatttt tcaactttga ataaagaata     2700

cttgaacttg tccttgttga atc                                             2723


<210> 3
<211> 1647
<212> PRT
<213> Homo sapiens

<400> 3
Met Ser Thr Pro Asp Pro Pro Leu Gly Gly Thr Pro Arg Pro Gly Pro 
1               5                   10                  15      


Ser Pro Gly Pro Gly Pro Ser Pro Gly Ala Met Leu Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Ser Pro Gly Ser Ala His Ser Met Met Gly Pro Ser Pro Gly 
        35                  40                  45              


Pro Pro Ser Ala Gly His Pro Ile Pro Thr Gln Gly Pro Gly Gly Tyr 
    50                  55                  60                  


Pro Gln Asp Asn Met His Gln Met His Lys Pro Met Glu Ser Met His 
65                  70                  75                  80  


Glu Lys Gly Met Ser Asp Asp Pro Arg Tyr Asn Gln Met Lys Gly Met 
                85                  90                  95      


Gly Met Arg Ser Gly Gly His Ala Gly Met Gly Pro Pro Pro Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Pro Ser Pro Leu Gly Gly Ser Glu 
        115                 120                 125             


His Ala Ser Ser Pro Val Pro Ala Ser Gly Pro Ser Ser Gly Pro Gln 
    130                 135                 140                 


Met Ser Ser Gly Pro Gly Gly Ala Pro Leu Asp Gly Ala Asp Pro Gln 
145                 150                 155                 160 


Ala Leu Gly Gln Gln Asn Arg Gly Pro Thr Pro Phe Asn Gln Asn Gln 
                165                 170                 175     


Leu His Gln Leu Arg Ala Gln Ile Met Ala Tyr Lys Met Leu Ala Arg 
            180                 185                 190         


Gly Gln Pro Leu Pro Asp His Leu Gln Met Ala Val Gln Gly Lys Arg 
        195                 200                 205             


Pro Met Pro Gly Met Gln Gln Gln Met Pro Thr Leu Pro Pro Pro Ser 
    210                 215                 220                 


Val Ser Ala Thr Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
225                 230                 235                 240 


Gly Pro Gly Pro Ala Pro Pro Asn Tyr Ser Arg Pro His Gly Met Gly 
                245                 250                 255     


Gly Pro Asn Met Pro Pro Pro Gly Pro Ser Gly Val Pro Pro Gly Met 
            260                 265                 270         


Pro Gly Gln Pro Pro Gly Gly Pro Pro Lys Pro Trp Pro Glu Gly Pro 
        275                 280                 285             


Met Ala Asn Ala Ala Ala Pro Thr Ser Thr Pro Gln Lys Leu Ile Pro 
    290                 295                 300                 


Pro Gln Pro Thr Gly Arg Pro Ser Pro Ala Pro Pro Ala Val Pro Pro 
305                 310                 315                 320 


Ala Ala Ser Pro Val Met Pro Pro Gln Thr Gln Ser Pro Gly Gln Pro 
                325                 330                 335     


Ala Gln Pro Ala Pro Met Val Pro Leu His Gln Lys Gln Ser Arg Ile 
            340                 345                 350         


Thr Pro Ile Gln Lys Pro Arg Gly Leu Asp Pro Val Glu Ile Leu Gln 
        355                 360                 365             


Glu Arg Glu Tyr Arg Leu Gln Ala Arg Ile Ala His Arg Ile Gln Glu 
    370                 375                 380                 


Leu Glu Asn Leu Pro Gly Ser Leu Ala Gly Asp Leu Arg Thr Lys Ala 
385                 390                 395                 400 


Thr Ile Glu Leu Lys Ala Leu Arg Leu Leu Asn Phe Gln Arg Gln Leu 
                405                 410                 415     


Arg Gln Glu Val Val Val Cys Met Arg Arg Asp Thr Ala Leu Glu Thr 
            420                 425                 430         


Ala Leu Asn Ala Lys Ala Tyr Lys Arg Ser Lys Arg Gln Ser Leu Arg 
        435                 440                 445             


Glu Ala Arg Ile Thr Glu Lys Leu Glu Lys Gln Gln Lys Ile Glu Gln 
    450                 455                 460                 


Glu Arg Lys Arg Arg Gln Lys His Gln Glu Tyr Leu Asn Ser Ile Leu 
465                 470                 475                 480 


Gln His Ala Lys Asp Phe Lys Glu Tyr His Arg Ser Val Thr Gly Lys 
                485                 490                 495     


Ile Gln Lys Leu Thr Lys Ala Val Ala Thr Tyr His Ala Asn Thr Glu 
            500                 505                 510         


Arg Glu Gln Lys Lys Glu Asn Glu Arg Ile Glu Lys Glu Arg Met Arg 
        515                 520                 525             


Arg Leu Met Ala Glu Asp Glu Glu Gly Tyr Arg Lys Leu Ile Asp Gln 
    530                 535                 540                 


Lys Lys Asp Lys Arg Leu Ala Tyr Leu Leu Gln Gln Thr Asp Glu Tyr 
545                 550                 555                 560 


Val Ala Asn Leu Thr Glu Leu Val Arg Gln His Lys Ala Ala Gln Val 
                565                 570                 575     


Ala Lys Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Ala Glu Asn Ala 
            580                 585                 590         


Glu Gly Gln Thr Pro Ala Ile Gly Pro Asp Gly Glu Pro Leu Asp Glu 
        595                 600                 605             


Thr Ser Gln Met Ser Asp Leu Pro Val Lys Val Ile His Val Glu Ser 
    610                 615                 620                 


Gly Lys Ile Leu Thr Gly Thr Asp Ala Pro Lys Ala Gly Gln Leu Glu 
625                 630                 635                 640 


Ala Trp Leu Glu Met Asn Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp 
                645                 650                 655     


Ser Glu Glu Ser Gly Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gln Pro Gln Ala Ala Gln Pro Pro Thr Leu Pro Val Glu Glu Lys Lys 
        675                 680                 685             


Lys Ile Pro Asp Pro Asp Ser Asp Asp Val Ser Glu Val Asp Ala Arg 
    690                 695                 700                 


His Ile Ile Glu Asn Ala Lys Gln Asp Val Asp Asp Glu Tyr Gly Val 
705                 710                 715                 720 


Ser Gln Ala Leu Ala Arg Gly Leu Gln Ser Tyr Tyr Ala Val Ala His 
                725                 730                 735     


Ala Val Thr Glu Arg Val Asp Lys Gln Ser Ala Leu Met Val Asn Gly 
            740                 745                 750         


Val Leu Lys Gln Tyr Gln Ile Lys Gly Leu Glu Trp Leu Val Ser Leu 
        755                 760                 765             


Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly 
    770                 775                 780                 


Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu His Lys 
785                 790                 795                 800 


Arg Ile Asn Gly Pro Phe Leu Ile Ile Val Pro Leu Ser Thr Leu Ser 
                805                 810                 815     


Asn Trp Ala Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val Lys Val 
            820                 825                 830         


Ser Tyr Lys Gly Ser Pro Ala Ala Arg Arg Ala Phe Val Pro Gln Leu 
        835                 840                 845             


Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr Ile Ile 
    850                 855                 860                 


Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met Ile Val 
865                 870                 875                 880 


Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr Gln Val 
                885                 890                 895     


Leu Asn Thr His Tyr Val Ala Pro Arg Arg Leu Leu Leu Thr Gly Thr 
            900                 905                 910         


Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn Phe Leu 
        915                 920                 925             


Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp Phe Asn 
    930                 935                 940                 


Ala Pro Phe Ala Met Thr Gly Glu Lys Val Asp Leu Asn Glu Glu Glu 
945                 950                 955                 960 


Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro Phe Leu 
                965                 970                 975     


Leu Arg Arg Leu Lys Lys Glu Val Glu Ala Gln Leu Pro Glu Lys Val 
            980                 985                 990         


Glu Tyr Val Ile Lys Cys Asp Met  Ser Ala Leu Gln Arg  Val Leu Tyr 
        995                 1000                 1005             


Arg His  Met Gln Ala Lys Gly  Val Leu Leu Thr Asp  Gly Ser Glu 
    1010                 1015                 1020             


Lys Asp  Lys Lys Gly Lys Gly  Gly Thr Lys Thr Leu  Met Asn Thr 
    1025                 1030                 1035             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1040                 1045                 1050             


His Ile  Glu Glu Ser Phe Ser  Glu His Leu Gly Phe  Thr Gly Gly 
    1055                 1060                 1065             


Ile Val  Gln Gly Leu Asp Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1070                 1075                 1080             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Lys 
    1085                 1090                 1095             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1100                 1105                 1110             


Asp Tyr  Phe Ala Tyr Arg Gly  Phe Lys Tyr Leu Arg  Leu Asp Gly 
    1115                 1120                 1125             


Thr Thr  Lys Ala Glu Asp Arg  Gly Met Leu Leu Lys  Thr Phe Asn 
    1130                 1135                 1140             


Glu Pro  Gly Ser Glu Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1145                 1150                 1155             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ser Ala Asp Thr  Val Ile Ile 
    1160                 1165                 1170             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1175                 1180                 1185             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1190                 1195                 1200             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1205                 1210                 1215             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1220                 1225                 1230             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1235                 1240                 1245             


Ala Ile  Leu Glu His Glu Glu  Gln Asp Glu Ser Arg  His Cys Ser 
    1250                 1255                 1260             


Thr Gly  Ser Gly Ser Ala Ser  Phe Ala His Thr Ala  Pro Pro Pro 
    1265                 1270                 1275             


Ala Gly  Val Asn Pro Asp Leu  Glu Glu Pro Pro Leu  Lys Glu Glu 
    1280                 1285                 1290             


Asp Glu  Val Pro Asp Asp Glu  Thr Val Asn Gln Met  Ile Ala Arg 
    1295                 1300                 1305             


His Glu  Glu Glu Phe Asp Leu  Phe Met Arg Met Asp  Leu Asp Arg 
    1310                 1315                 1320             


Arg Arg  Glu Glu Ala Arg Asn  Pro Lys Arg Lys Pro  Arg Leu Met 
    1325                 1330                 1335             


Glu Glu  Asp Glu Leu Pro Ser  Trp Ile Ile Lys Asp  Asp Ala Glu 
    1340                 1345                 1350             


Val Glu  Arg Leu Thr Cys Glu  Glu Glu Glu Glu Lys  Met Phe Gly 
    1355                 1360                 1365             


Arg Gly  Ser Arg His Arg Lys  Glu Val Asp Tyr Ser  Asp Ser Leu 
    1370                 1375                 1380             


Thr Glu  Lys Gln Trp Leu Lys  Ala Ile Glu Glu Gly  Thr Leu Glu 
    1385                 1390                 1395             


Glu Ile  Glu Glu Glu Val Arg  Gln Lys Lys Ser Ser  Arg Lys Arg 
    1400                 1405                 1410             


Lys Arg  Asp Ser Asp Ala Gly  Ser Ser Thr Pro Thr  Thr Ser Thr 
    1415                 1420                 1425             


Arg Ser  Arg Asp Lys Asp Asp  Glu Ser Lys Lys Gln  Lys Lys Arg 
    1430                 1435                 1440             


Gly Arg  Pro Pro Ala Glu Lys  Leu Ser Pro Asn Pro  Pro Asn Leu 
    1445                 1450                 1455             


Thr Lys  Lys Met Lys Lys Ile  Val Asp Ala Val Ile  Lys Tyr Lys 
    1460                 1465                 1470             


Asp Ser  Ser Ser Gly Arg Gln  Leu Ser Glu Val Phe  Ile Gln Leu 
    1475                 1480                 1485             


Pro Ser  Arg Lys Glu Leu Pro  Glu Tyr Tyr Glu Leu  Ile Arg Lys 
    1490                 1495                 1500             


Pro Val  Asp Phe Lys Lys Ile  Lys Glu Arg Ile Arg  Asn His Lys 
    1505                 1510                 1515             


Tyr Arg  Ser Leu Asn Asp Leu  Glu Lys Asp Val Met  Leu Leu Cys 
    1520                 1525                 1530             


Gln Asn  Ala Gln Thr Phe Asn  Leu Glu Gly Ser Leu  Ile Tyr Glu 
    1535                 1540                 1545             


Asp Ser  Ile Val Leu Gln Ser  Val Phe Thr Ser Val  Arg Gln Lys 
    1550                 1555                 1560             


Ile Glu  Lys Glu Asp Asp Ser  Glu Gly Glu Glu Ser  Glu Glu Glu 
    1565                 1570                 1575             


Glu Glu  Gly Glu Glu Glu Gly  Ser Glu Ser Glu Ser  Arg Ser Val 
    1580                 1585                 1590             


Lys Val  Lys Ile Lys Leu Gly  Arg Lys Glu Lys Ala  Gln Asp Arg 
    1595                 1600                 1605             


Leu Lys  Gly Gly Arg Arg Arg  Pro Ser Arg Gly Ser  Arg Ala Lys 
    1610                 1615                 1620             


Pro Val  Val Ser Asp Asp Asp  Ser Glu Glu Glu Gln  Glu Glu Asp 
    1625                 1630                 1635             


Arg Ser  Gly Ser Gly Ser Glu  Glu Asp 
    1640                 1645         


<210> 4
<211> 5779
<212> DNA
<213> Homo sapiens

<400> 4
ggagaggccg ccgcggtgct gagggggagg ggagccggcg agcgcgcgcg cagcgggggc       60

gcgggtggcg cgcgtgtgtg tgaagggggg gcggtggccg aggcgggcgg gcgcgcgcgc      120

gaggcttccc ctcgtttggc ggcggcggcg gcttctttgt ttcgtgaaga gaagcgagac      180

gcccattctg cccccggccc cgcgcggagg ggcgggggag gcgccgggaa gtcgacggcg      240

ccggcggctc ctgcgtctcg cccttttgcc caggctagag tgcagtggtg cggtcatggt      300

tcactgcagc ctcaacctcc tggactcagc aggaggccac tgtctgcagc tcccgtgaag      360

atgtccactc cagacccacc cctgggcgga actcctcggc caggtccttc cccgggccct      420

ggcccttccc ctggagccat gctgggccct agcccgggtc cctcgccggg ctccgcccac      480

agcatgatgg ggcccagccc agggccgccc tcagcaggac accccatccc cacccagggg      540

cctggagggt accctcagga caacatgcac cagatgcaca agcccatgga gtccatgcat      600

gagaagggca tgtcggacga cccgcgctac aaccagatga aaggaatggg gatgcggtca      660

gggggccatg ctgggatggg gcccccgccc agccccatgg accagcactc ccaaggttac      720

ccctcgcccc tgggtggctc tgagcatgcc tctagtccag ttccagccag tggcccgtct      780

tcggggcccc agatgtcttc cgggccagga ggtgccccgc tggatggtgc tgacccccag      840

gccttggggc agcagaaccg gggcccaacc ccatttaacc agaaccagct gcaccagctc      900

agagctcaga tcatggccta caagatgctg gccagggggc agcccctccc cgaccacctg      960

cagatggcgg tgcagggcaa gcggccgatg cccgggatgc agcagcagat gccaacgcta     1020

cctccaccct cggtgtccgc aacaggaccc ggccctggcc ctggccctgg ccccggcccg     1080

ggtcccggcc cggcacctcc aaattacagc aggcctcatg gtatgggagg gcccaacatg     1140

cctcccccag gaccctcggg cgtgcccccc gggatgccag gccagcctcc tggagggcct     1200

cccaagccct ggcctgaagg acccatggcg aatgctgctg cccccacgag cacccctcag     1260

aagctgattc ccccgcagcc aacgggccgc ccttcccccg cgccccctgc cgtcccaccc     1320

gccgcctcgc ccgtgatgcc accgcagacc cagtcccccg ggcagccggc ccagcccgcg     1380

cccatggtgc cactgcacca gaagcagagc cgcatcaccc ccatccagaa gccgcggggc     1440

ctcgaccctg tggagatcct gcaggagcgc gagtacaggc tgcaggctcg catcgcacac     1500

cgaattcagg aacttgaaaa ccttcccggg tccctggccg gggatttgcg aaccaaagcg     1560

accattgagc tcaaggccct caggctgctg aacttccaga ggcagctgcg ccaggaggtg     1620

gtggtgtgca tgcggaggga cacagcgctg gagacagccc tcaatgctaa ggcctacaag     1680

cgcagcaagc gccagtccct gcgcgaggcc cgcatcactg agaagctgga gaagcagcag     1740

aagatcgagc aggagcgcaa gcgccggcag aagcaccagg aatacctcaa tagcattctc     1800

cagcatgcca aggatttcaa ggaatatcac agatccgtca caggcaaaat ccagaagctg     1860

accaaggcag tggccacgta ccatgccaac acggagcggg agcagaagaa agagaacgag     1920

cggatcgaga aggagcgcat gcggaggctc atggctgaag atgaggaggg gtaccgcaag     1980

ctcatcgacc agaagaagga caagcgcctg gcctacctct tgcagcagac agacgagtac     2040

gtggctaacc tcacggagct ggtgcggcag cacaaggctg cccaggtcgc caaggagaaa     2100

aagaagaaaa agaaaaagaa gaaggcagaa aatgcagaag gacagacgcc tgccattggg     2160

ccggatggcg agcctctgga cgagaccagc cagatgagcg acctcccggt gaaggtgatc     2220

cacgtggaga gtgggaagat cctcacaggc acagatgccc ccaaagccgg gcagctggag     2280

gcctggctcg agatgaaccc ggggtatgaa gtagctccga ggtctgatag tgaagaaagt     2340

ggctcagaag aagaggaaga ggaggaggag gaagagcagc cgcaggcagc acagcctccc     2400

accctgcccg tggaggagaa gaagaagatt ccagatccag acagcgatga cgtctctgag     2460

gtggacgcgc ggcacatcat tgagaatgcc aagcaagatg tcgatgatga atatggcgtg     2520

tcccaggccc ttgcacgtgg cctgcagtcc tactatgccg tggcccatgc tgtcactgag     2580

agagtggaca agcagtcagc gcttatggtc aatggtgtcc tcaaacagta ccagatcaaa     2640

ggtttggagt ggctggtgtc cctgtacaac aacaacctga acggcatcct ggccgacgag     2700

atgggcctgg ggaagaccat ccagaccatc gcgctcatca cgtacctcat ggagcacaaa     2760

cgcatcaatg ggcccttcct catcatcgtg cctctctcaa cgctgtccaa ctgggcgtac     2820

gagtttgaca agtgggcccc ctccgtggtg aaggtgtctt acaagggatc cccagcagca     2880

agacgggcct ttgtccccca gctccggagt gggaagttca acgtcttgct gacgacgtac     2940

gagtacatca tcaaagacaa gcacatcctc gccaagatcc gttggaagta catgattgtg     3000

gacgaaggtc accgcatgaa gaaccaccac tgcaagctga cgcaggtgct caacacgcac     3060

tatgtggcac cccgccgcct gctgctgacg ggcacaccgc tgcagaacaa gcttcccgag     3120

ctctgggcgc tgctcaactt cctgctgccc accatcttca agagctgcag caccttcgag     3180

cagtggttta acgcaccctt tgccatgacc ggggaaaagg tggacctgaa tgaggaggaa     3240

accattctca tcatccggcg tctccacaaa gtgctgcggc ccttcttgct ccgacgactc     3300

aagaaggaag tcgaggccca gttgcccgaa aaggtggagt acgtcatcaa gtgcgacatg     3360

tctgcgctgc agcgagtgct ctaccgccac atgcaggcca agggcgtgct gctgactgat     3420

ggctccgaga aggacaagaa gggcaaaggc ggcaccaaga ccctgatgaa caccatcatg     3480

cagctgcgga agatctgcaa ccacccctac atgttccagc acatcgagga gtccttttcc     3540

gagcacttgg ggttcactgg cggcattgtc caagggctgg acctgtaccg agcctcgggt     3600

aaatttgagc ttcttgatag aattcttccc aaactccgag caaccaacca caaagtgctg     3660

ctgttctgcc aaatgacctc cctcatgacc atcatggaag attactttgc gtatcgcggc     3720

tttaaatacc tcaggcttga tggaaccacg aaggcggagg accggggcat gctgctgaaa     3780

accttcaacg agcccggctc tgagtacttc atcttcctgc tcagcacccg ggctgggggg     3840

ctcggcctga acctccagtc ggcagacact gtgatcattt ttgacagcga ctggaatcct     3900

caccaggacc tgcaagcgca ggaccgagcc caccgcatcg ggcagcagaa cgaggtgcgt     3960

gtgctccgcc tctgcaccgt caacagcgtg gaggagaaga tcctagctgc agccaagtac     4020

aagctcaacg tggaccagaa ggtgatccag gccggcatgt tcgaccagaa gtcctccagc     4080

catgagcggc gcgccttcct gcaggccatc ctggagcacg aggagcagga tgagagcaga     4140

cactgcagca cgggcagcgg cagtgccagc ttcgcccaca ctgcccctcc gccagcgggc     4200

gtcaaccccg acttggagga gccacctcta aaggaggaag acgaggtgcc cgacgacgag     4260

accgtcaacc agatgatcgc ccggcacgag gaggagtttg atctgttcat gcgcatggac     4320

ctggaccgca ggcgcgagga ggcccgcaac cccaagcgga agccgcgcct catggaggag     4380

gacgagctcc cctcgtggat catcaaggac gacgcggagg tggagcggct gacctgtgag     4440

gaggaggagg agaagatgtt cggccgtggc tcccgccacc gcaaggaggt ggactacagc     4500

gactcactga cggagaagca gtggctcaag gccatcgagg agggcacgct ggaggagatc     4560

gaagaggagg tccggcagaa gaaatcatca cggaagcgca agcgagacag cgacgccggc     4620

tcctccaccc cgaccaccag cacccgcagc cgcgacaagg acgacgagag caagaagcag     4680

aagaagcgcg ggcggccgcc tgccgagaaa ctctccccta acccacccaa cctcaccaag     4740

aagatgaaga agattgtgga tgccgtgatc aagtacaagg acagcagcag tggacgtcag     4800

ctcagcgagg tcttcatcca gctgccctcg cgaaaggagc tgcccgagta ctacgagctc     4860

atccgcaagc ccgtggactt caagaagata aaggagcgca ttcgcaacca caagtaccgc     4920

agcctcaacg acctagagaa ggacgtcatg ctcctgtgcc agaacgcaca gaccttcaac     4980

ctggagggct ccctgatcta tgaagactcc atcgtcttgc agtcggtctt caccagcgtg     5040

cggcagaaaa tcgagaagga ggatgacagt gaaggcgagg agagtgagga ggaggaagag     5100

ggcgaggagg aaggctccga atccgaatct cggtccgtca aagtgaagat caagcttggc     5160

cggaaggaga aggcacagga ccggctgaag ggcggccggc ggcggccgag ccgagggtcc     5220

cgagccaagc cggtcgtgag tgacgatgac agtgaggagg aacaagagga ggaccgctca     5280

ggaagtggca gcgaagaaga ctgagccccg acattccagt ctcgaccccg agcccctcgt     5340

tccagagctg agatggcata ggccttagca gtaacgggta gcagcagatg tagtttcaga     5400

cttggagtaa aactgtataa acaaaagaat cttccatatt tatacagcag agaagctgta     5460

ggactgtttg tgactggccc tgtcctggca tcagtagcat ctgtaacagc attaactgtc     5520

ttaaagagag agagagagaa ttccgaattg gggaacacac gatacctgtt tttcttttcc     5580

gttgctggca gtactgttgc gccgcagttt ggagtcactg tagttaagtg tggatgcatg     5640

tgcgtcaccg tccactcctc ctactgtatt ttattggaca ggtcagactc gccgggggcc     5700

cggcgagggt atgtcagtgt cactggatgt caaacagtaa taaattaaac caacaacaaa     5760

acgcacagcc aaaaaaaaa                                                  5779


<210> 5
<211> 1210
<212> PRT
<213> Homo sapiens

<400> 5
Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210> 6
<211> 5616
<212> DNA
<213> Homo sapiens

<400> 6
ccccggcgca gcgcggccgc agcagcctcc gccccccgca cggtgtgagc gcccgacgcg       60

gccgaggcgg ccggagtccc gagctagccc cggcggccgc cgccgcccag accggacgac      120

aggccacctc gtcggcgtcc gcccgagtcc ccgcctcgcc gccaacgcca caaccaccgc      180

gcacggcccc ctgactccgt ccagtattga tcgggagagc cggagcgagc tcttcgggga      240

gcagcgatgc gaccctccgg gacggccggg gcagcgctcc tggcgctgct ggctgcgctc      300

tgcccggcga gtcgggctct ggaggaaaag aaagtttgcc aaggcacgag taacaagctc      360

acgcagttgg gcacttttga agatcatttt ctcagcctcc agaggatgtt caataactgt      420

gaggtggtcc ttgggaattt ggaaattacc tatgtgcaga ggaattatga tctttccttc      480

ttaaagacca tccaggaggt ggctggttat gtcctcattg ccctcaacac agtggagcga      540

attcctttgg aaaacctgca gatcatcaga ggaaatatgt actacgaaaa ttcctatgcc      600

ttagcagtct tatctaacta tgatgcaaat aaaaccggac tgaaggagct gcccatgaga      660

aatttacagg aaatcctgca tggcgccgtg cggttcagca acaaccctgc cctgtgcaac      720

gtggagagca tccagtggcg ggacatagtc agcagtgact ttctcagcaa catgtcgatg      780

gacttccaga accacctggg cagctgccaa aagtgtgatc caagctgtcc caatgggagc      840

tgctggggtg caggagagga gaactgccag aaactgacca aaatcatctg tgcccagcag      900

tgctccgggc gctgccgtgg caagtccccc agtgactgct gccacaacca gtgtgctgca      960

ggctgcacag gcccccggga gagcgactgc ctggtctgcc gcaaattccg agacgaagcc     1020

acgtgcaagg acacctgccc cccactcatg ctctacaacc ccaccacgta ccagatggat     1080

gtgaaccccg agggcaaata cagctttggt gccacctgcg tgaagaagtg tccccgtaat     1140

tatgtggtga cagatcacgg ctcgtgcgtc cgagcctgtg gggccgacag ctatgagatg     1200

gaggaagacg gcgtccgcaa gtgtaagaag tgcgaagggc cttgccgcaa agtgtgtaac     1260

ggaataggta ttggtgaatt taaagactca ctctccataa atgctacgaa tattaaacac     1320

ttcaaaaact gcacctccat cagtggcgat ctccacatcc tgccggtggc atttaggggt     1380

gactccttca cacatactcc tcctctggat ccacaggaac tggatattct gaaaaccgta     1440

aaggaaatca cagggttttt gctgattcag gcttggcctg aaaacaggac ggacctccat     1500

gcctttgaga acctagaaat catacgcggc aggaccaagc aacatggtca gttttctctt     1560

gcagtcgtca gcctgaacat aacatccttg ggattacgct ccctcaagga gataagtgat     1620

ggagatgtga taatttcagg aaacaaaaat ttgtgctatg caaatacaat aaactggaaa     1680

aaactgtttg ggacctccgg tcagaaaacc aaaattataa gcaacagagg tgaaaacagc     1740

tgcaaggcca caggccaggt ctgccatgcc ttgtgctccc ccgagggctg ctggggcccg     1800

gagcccaggg actgcgtctc ttgccggaat gtcagccgag gcagggaatg cgtggacaag     1860

tgcaaccttc tggagggtga gccaagggag tttgtggaga actctgagtg catacagtgc     1920

cacccagagt gcctgcctca ggccatgaac atcacctgca caggacgggg accagacaac     1980

tgtatccagt gtgcccacta cattgacggc ccccactgcg tcaagacctg cccggcagga     2040

gtcatgggag aaaacaacac cctggtctgg aagtacgcag acgccggcca tgtgtgccac     2100

ctgtgccatc caaactgcac ctacggatgc actgggccag gtcttgaagg ctgtccaacg     2160

aatgggccta agatcccgtc catcgccact gggatggtgg gggccctcct cttgctgctg     2220

gtggtggccc tggggatcgg cctcttcatg cgaaggcgcc acatcgttcg gaagcgcacg     2280

ctgcggaggc tgctgcagga gagggagctt gtggagcctc ttacacccag tggagaagct     2340

cccaaccaag ctctcttgag gatcttgaag gaaactgaat tcaaaaagat caaagtgctg     2400

ggctccggtg cgttcggcac ggtgtataag ggactctgga tcccagaagg tgagaaagtt     2460

aaaattcccg tcgctatcaa ggaattaaga gaagcaacat ctccgaaagc caacaaggaa     2520

atcctcgatg aagcctacgt gatggccagc gtggacaacc cccacgtgtg ccgcctgctg     2580

ggcatctgcc tcacctccac cgtgcagctc atcacgcagc tcatgccctt cggctgcctc     2640

ctggactatg tccgggaaca caaagacaat attggctccc agtacctgct caactggtgt     2700

gtgcagatcg caaagggcat gaactacttg gaggaccgtc gcttggtgca ccgcgacctg     2760

gcagccagga acgtactggt gaaaacaccg cagcatgtca agatcacaga ttttgggctg     2820

gccaaactgc tgggtgcgga agagaaagaa taccatgcag aaggaggcaa agtgcctatc     2880

aagtggatgg cattggaatc aattttacac agaatctata cccaccagag tgatgtctgg     2940

agctacgggg tgaccgtttg ggagttgatg acctttggat ccaagccata tgacggaatc     3000

cctgccagcg agatctcctc catcctggag aaaggagaac gcctccctca gccacccata     3060

tgtaccatcg atgtctacat gatcatggtc aagtgctgga tgatagacgc agatagtcgc     3120

ccaaagttcc gtgagttgat catcgaattc tccaaaatgg cccgagaccc ccagcgctac     3180

cttgtcattc agggggatga aagaatgcat ttgccaagtc ctacagactc caacttctac     3240

cgtgccctga tggatgaaga agacatggac gacgtggtgg atgccgacga gtacctcatc     3300

ccacagcagg gcttcttcag cagcccctcc acgtcacgga ctcccctcct gagctctctg     3360

agtgcaacca gcaacaattc caccgtggct tgcattgata gaaatgggct gcaaagctgt     3420

cccatcaagg aagacagctt cttgcagcga tacagctcag accccacagg cgccttgact     3480

gaggacagca tagacgacac cttcctccca gtgcctgaat acataaacca gtccgttccc     3540

aaaaggcccg ctggctctgt gcagaatcct gtctatcaca atcagcctct gaaccccgcg     3600

cccagcagag acccacacta ccaggacccc cacagcactg cagtgggcaa ccccgagtat     3660

ctcaacactg tccagcccac ctgtgtcaac agcacattcg acagccctgc ccactgggcc     3720

cagaaaggca gccaccaaat tagcctggac aaccctgact accagcagga cttctttccc     3780

aaggaagcca agccaaatgg catctttaag ggctccacag ctgaaaatgc agaataccta     3840

agggtcgcgc cacaaagcag tgaatttatt ggagcatgac cacggaggat agtatgagcc     3900

ctaaaaatcc agactctttc gatacccagg accaagccac agcaggtcct ccatcccaac     3960

agccatgccc gcattagctc ttagacccac agactggttt tgcaacgttt acaccgacta     4020

gccaggaagt acttccacct cgggcacatt ttgggaagtt gcattccttt gtcttcaaac     4080

tgtgaagcat ttacagaaac gcatccagca agaatattgt ccctttgagc agaaatttat     4140

ctttcaaaga ggtatatttg aaaaaaaaaa aaagtatatg tgaggatttt tattgattgg     4200

ggatcttgga gtttttcatt gtcgctattg atttttactt caatgggctc ttccaacaag     4260

gaagaagctt gctggtagca cttgctaccc tgagttcatc caggcccaac tgtgagcaag     4320

gagcacaagc cacaagtctt ccagaggatg cttgattcca gtggttctgc ttcaaggctt     4380

ccactgcaaa acactaaaga tccaagaagg ccttcatggc cccagcaggc cggatcggta     4440

ctgtatcaag tcatggcagg tacagtagga taagccactc tgtcccttcc tgggcaaaga     4500

agaaacggag gggatggaat tcttccttag acttactttt gtaaaaatgt ccccacggta     4560

cttactcccc actgatggac cagtggtttc cagtcatgag cgttagactg acttgtttgt     4620

cttccattcc attgttttga aactcagtat gctgcccctg tcttgctgtc atgaaatcag     4680

caagagagga tgacacatca aataataact cggattccag cccacattgg attcatcagc     4740

atttggacca atagcccaca gctgagaatg tggaatacct aaggatagca ccgcttttgt     4800

tctcgcaaaa acgtatctcc taatttgagg ctcagatgaa atgcatcagg tcctttgggg     4860

catagatcag aagactacaa aaatgaagct gctctgaaat ctcctttagc catcacccca     4920

accccccaaa attagtttgt gttacttatg gaagatagtt ttctcctttt acttcacttc     4980

aaaagctttt tactcaaaga gtatatgttc cctccaggtc agctgccccc aaaccccctc     5040

cttacgcttt gtcacacaaa aagtgtctct gccttgagtc atctattcaa gcacttacag     5100

ctctggccac aacagggcat tttacaggtg cgaatgacag tagcattatg agtagtgtgg     5160

aattcaggta gtaaatatga aactagggtt tgaaattgat aatgctttca caacatttgc     5220

agatgtttta gaaggaaaaa agttccttcc taaaataatt tctctacaat tggaagattg     5280

gaagattcag ctagttagga gcccaccttt tttcctaatc tgtgtgtgcc ctgtaacctg     5340

actggttaac agcagtcctt tgtaaacagt gttttaaact ctcctagtca atatccaccc     5400

catccaattt atcaaggaag aaatggttca gaaaatattt tcagcctaca gttatgttca     5460

gtcacacaca catacaaaat gttccttttg cttttaaagt aatttttgac tcccagatca     5520

gtcagagccc ctacagcatt gttaagaaag tatttgattt ttgtctcaat gaaaataaaa     5580

ctatattcat ttccactcta aaaaaaaaaa aaaaaa                               5616


<210> 7
<211> 766
<212> PRT
<213> Homo sapiens

<400> 7
Met Ala Ala Leu Ser Gly Gly Gly Gly Gly Gly Ala Glu Pro Gly Gln 
1               5                   10                  15      


Ala Leu Phe Asn Gly Asp Met Glu Pro Glu Ala Gly Ala Gly Ala Gly 
            20                  25                  30          


Ala Ala Ala Ser Ser Ala Ala Asp Pro Ala Ile Pro Glu Glu Val Trp 
        35                  40                  45              


Asn Ile Lys Gln Met Ile Lys Leu Thr Gln Glu His Ile Glu Ala Leu 
    50                  55                  60                  


Leu Asp Lys Phe Gly Gly Glu His Asn Pro Pro Ser Ile Tyr Leu Glu 
65                  70                  75                  80  


Ala Tyr Glu Glu Tyr Thr Ser Lys Leu Asp Ala Leu Gln Gln Arg Glu 
                85                  90                  95      


Gln Gln Leu Leu Glu Ser Leu Gly Asn Gly Thr Asp Phe Ser Val Ser 
            100                 105                 110         


Ser Ser Ala Ser Met Asp Thr Val Thr Ser Ser Ser Ser Ser Ser Leu 
        115                 120                 125             


Ser Val Leu Pro Ser Ser Leu Ser Val Phe Gln Asn Pro Thr Asp Val 
    130                 135                 140                 


Ala Arg Ser Asn Pro Lys Ser Pro Gln Lys Pro Ile Val Arg Val Phe 
145                 150                 155                 160 


Leu Pro Asn Lys Gln Arg Thr Val Val Pro Ala Arg Cys Gly Val Thr 
                165                 170                 175     


Val Arg Asp Ser Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile Pro 
            180                 185                 190         


Glu Cys Cys Ala Val Tyr Arg Ile Gln Asp Gly Glu Lys Lys Pro Ile 
        195                 200                 205             


Gly Trp Asp Thr Asp Ile Ser Trp Leu Thr Gly Glu Glu Leu His Val 
    210                 215                 220                 


Glu Val Leu Glu Asn Val Pro Leu Thr Thr His Asn Phe Val Arg Lys 
225                 230                 235                 240 


Thr Phe Phe Thr Leu Ala Phe Cys Asp Phe Cys Arg Lys Leu Leu Phe 
                245                 250                 255     


Gln Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Gln Arg Cys 
            260                 265                 270         


Ser Thr Glu Val Pro Leu Met Cys Val Asn Tyr Asp Gln Leu Asp Leu 
        275                 280                 285             


Leu Phe Val Ser Lys Phe Phe Glu His His Pro Ile Pro Gln Glu Glu 
    290                 295                 300                 


Ala Ser Leu Ala Glu Thr Ala Leu Thr Ser Gly Ser Ser Pro Ser Ala 
305                 310                 315                 320 


Pro Ala Ser Asp Ser Ile Gly Pro Gln Ile Leu Thr Ser Pro Ser Pro 
                325                 330                 335     


Ser Lys Ser Ile Pro Ile Pro Gln Pro Phe Arg Pro Ala Asp Glu Asp 
            340                 345                 350         


His Arg Asn Gln Phe Gly Gln Arg Asp Arg Ser Ser Ser Ala Pro Asn 
        355                 360                 365             


Val His Ile Asn Thr Ile Glu Pro Val Asn Ile Asp Asp Leu Ile Arg 
    370                 375                 380                 


Asp Gln Gly Phe Arg Gly Asp Gly Gly Ser Thr Thr Gly Leu Ser Ala 
385                 390                 395                 400 


Thr Pro Pro Ala Ser Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu 
                405                 410                 415     


Gln Lys Ser Pro Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser 
            420                 425                 430         


Glu Asp Arg Asn Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp 
        435                 440                 445             


Asp Trp Glu Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly 
    450                 455                 460                 


Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val 
465                 470                 475                 480 


Ala Val Lys Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu Gln 
                485                 490                 495     


Ala Phe Lys Asn Glu Val Gly Val Leu Arg Lys Thr Arg His Val Asn 
            500                 505                 510         


Ile Leu Leu Phe Met Gly Tyr Ser Thr Lys Pro Gln Leu Ala Ile Val 
        515                 520                 525             


Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Ile Ile 
    530                 535                 540                 


Glu Thr Lys Phe Glu Met Ile Lys Leu Ile Asp Ile Ala Arg Gln Thr 
545                 550                 555                 560 


Ala Gln Gly Met Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp 
                565                 570                 575     


Leu Lys Ser Asn Asn Ile Phe Leu His Glu Asp Leu Thr Val Lys Ile 
            580                 585                 590         


Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp Ser Gly Ser His 
        595                 600                 605             


Gln Phe Glu Gln Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val 
    610                 615                 620                 


Ile Arg Met Gln Asp Lys Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr 
625                 630                 635                 640 


Ala Phe Gly Ile Val Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr 
                645                 650                 655     


Ser Asn Ile Asn Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly 
            660                 665                 670         


Tyr Leu Ser Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala 
        675                 680                 685             


Met Lys Arg Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg 
    690                 695                 700                 


Pro Leu Phe Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser 
705                 710                 715                 720 


Leu Pro Lys Ile His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg Ala 
                725                 730                 735     


Gly Phe Gln Thr Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys 
            740                 745                 750         


Thr Pro Ile Gln Ala Gly Gly Tyr Gly Ala Phe Pro Val His 
        755                 760                 765     


<210> 8
<211> 2949
<212> DNA
<213> Homo sapiens

<400> 8
cgcctccctt ccccctcccc gcccgacagc ggccgctcgg gccccggctc tcggttataa       60

gatggcggcg ctgagcggtg gcggtggtgg cggcgcggag ccgggccagg ctctgttcaa      120

cggggacatg gagcccgagg ccggcgccgg cgccggcgcc gcggcctctt cggctgcgga      180

ccctgccatt ccggaggagg tgtggaatat caaacaaatg attaagttga cacaggaaca      240

tatagaggcc ctattggaca aatttggtgg ggagcataat ccaccatcaa tatatctgga      300

ggcctatgaa gaatacacca gcaagctaga tgcactccaa caaagagaac aacagttatt      360

ggaatctctg gggaacggaa ctgatttttc tgtttctagc tctgcatcaa tggataccgt      420

tacatcttct tcctcttcta gcctttcagt gctaccttca tctctttcag tttttcaaaa      480

tcccacagat gtggcacgga gcaaccccaa gtcaccacaa aaacctatcg ttagagtctt      540

cctgcccaac aaacagagga cagtggtacc tgcaaggtgt ggagttacag tccgagacag      600

tctaaagaaa gcactgatga tgagaggtct aatcccagag tgctgtgctg tttacagaat      660

tcaggatgga gagaagaaac caattggttg ggacactgat atttcctggc ttactggaga      720

agaattgcat gtggaagtgt tggagaatgt tccacttaca acacacaact ttgtacgaaa      780

aacgtttttc accttagcat tttgtgactt ttgtcgaaag ctgcttttcc agggtttccg      840

ctgtcaaaca tgtggttata aatttcacca gcgttgtagt acagaagttc cactgatgtg      900

tgttaattat gaccaacttg atttgctgtt tgtctccaag ttctttgaac accacccaat      960

accacaggaa gaggcgtcct tagcagagac tgccctaaca tctggatcat ccccttccgc     1020

acccgcctcg gactctattg ggccccaaat tctcaccagt ccgtctcctt caaaatccat     1080

tccaattcca cagcccttcc gaccagcaga tgaagatcat cgaaatcaat ttgggcaacg     1140

agaccgatcc tcatcagctc ccaatgtgca tataaacaca atagaacctg tcaatattga     1200

tgacttgatt agagaccaag gatttcgtgg tgatggagga tcaaccacag gtttgtctgc     1260

taccccccct gcctcattac ctggctcact aactaacgtg aaagccttac agaaatctcc     1320

aggacctcag cgagaaagga agtcatcttc atcctcagaa gacaggaatc gaatgaaaac     1380

acttggtaga cgggactcga gtgatgattg ggagattcct gatgggcaga ttacagtggg     1440

acaaagaatt ggatctggat catttggaac agtctacaag ggaaagtggc atggtgatgt     1500

ggcagtgaaa atgttgaatg tgacagcacc tacacctcag cagttacaag ccttcaaaaa     1560

tgaagtagga gtactcagga aaacacgaca tgtgaatatc ctactcttca tgggctattc     1620

cacaaagcca caactggcta ttgttaccca gtggtgtgag ggctccagct tgtatcacca     1680

tctccatatc attgagacca aatttgagat gatcaaactt atagatattg cacgacagac     1740

tgcacagggc atggattact tacacgccaa gtcaatcatc cacagagacc tcaagagtaa     1800

taatatattt cttcatgaag acctcacagt aaaaataggt gattttggtc tagctacagt     1860

gaaatctcga tggagtgggt cccatcagtt tgaacagttg tctggatcca ttttgtggat     1920

ggcaccagaa gtcatcagaa tgcaagataa aaatccatac agctttcagt cagatgtata     1980

tgcatttgga attgttctgt atgaattgat gactggacag ttaccttatt caaacatcaa     2040

caacagggac cagataattt ttatggtggg acgaggatac ctgtctccag atctcagtaa     2100

ggtacggagt aactgtccaa aagccatgaa gagattaatg gcagagtgcc tcaaaaagaa     2160

aagagatgag agaccactct ttccccaaat tctcgcctct attgagctgc tggcccgctc     2220

attgccaaaa attcaccgca gtgcatcaga accctccttg aatcgggctg gtttccaaac     2280

agaggatttt agtctatatg cttgtgcttc tccaaaaaca cccatccagg cagggggata     2340

tggtgcgttt cctgtccact gaaacaaatg agtgagagag ttcaggagag tagcaacaaa     2400

aggaaaataa atgaacatat gtttgcttat atgttaaatt gaataaaata ctctcttttt     2460

ttttaaggtg aaccaaagaa cacttgtgtg gttaaagact agatataatt tttccccaaa     2520

ctaaaattta tacttaacat tggattttta acatccaagg gttaaaatac atagacattg     2580

ctaaaaattg gcagagcctc ttctagaggc tttactttct gttccgggtt tgtatcattc     2640

acttggttat tttaagtagt aaacttcagt ttctcatgca acttttgttg ccagctatca     2700

catgtccact agggactcca gaagaagacc ctacctatgc ctgtgtttgc aggtgagaag     2760

ttggcagtcg gttagcctgg gttagataag gcaaactgaa cagatctaat ttaggaagtc     2820

agtagaattt aataattcta ttattattct taataatttt tctataacta tttcttttta     2880

taacaatttg gaaaatgtgg atgtctttta tttccttgaa gcaataaact aagtttcttt     2940

ttataaaaa                                                             2949


<210> 9
<211> 2708
<212> DNA
<213> Homo sapiens

<400> 9
ggcggcgctt gattgggctg ggggggccaa ataaaagcga tggcgattgg gctgccgcgt       60

ttggcgctcg gtccggtcgc gtccgacacc cggtgggact cagaaggcag tggagccccg      120

gcggcggcgg cggcggcgcg cgggggcgac gcgcgggaac aacgcgagtc ggcgcgcggg      180

acgaagaata atcatgggcc agactgggaa gaaatctgag aagggaccag tttgttggcg      240

gaagcgtgta aaatcagagt acatgcgact gagacagctc aagaggttca gacgagctga      300

tgaagtaaag agtatgttta gttccaatcg tcagaaaatt ttggaaagaa cggaaatctt      360

aaaccaagaa tggaaacagc gaaggataca gcctgtgcac atcctgactt ctgtgagctc      420

attgcgcggg actagggagt gttcggtgac cagtgacttg gattttccaa cacaagtcat      480

cccattaaag actctgaatg cagttgcttc agtacccata atgtattctt ggtctcccct      540

acagcagaat tttatggtgg aagatgaaac tgttttacat aacattcctt atatgggaga      600

tgaagtttta gatcaggatg gtactttcat tgaagaacta ataaaaaatt atgatgggaa      660

agtacacggg gatagagaat gtgggtttat aaatgatgaa atttttgtgg agttggtgaa      720

tgcccttggt caatataatg atgatgacga tgatgatgat ggagacgatc ctgaagaaag      780

agaagaaaag cagaaagatc tggaggatca ccgagatgat aaagaaagcc gcccacctcg      840

gaaatttcct tctgataaaa tttttgaagc catttcctca atgtttccag ataagggcac      900

agcagaagaa ctaaaggaaa aatataaaga actcaccgaa cagcagctcc caggcgcact      960

tcctcctgaa tgtaccccca acatagatgg accaaatgct aaatctgttc agagagagca     1020

aagcttacac tcctttcata cgcttttctg taggcgatgt tttaaatatg actgcttcct     1080

acatcctttt catgcaacac ccaacactta taagcggaag aacacagaaa cagctctaga     1140

caacaaacct tgtggaccac agtgttacca gcatttggag ggagcaaagg agtttgctgc     1200

tgctctcacc gctgagcgga taaagacccc accaaaacgt ccaggaggcc gcagaagagg     1260

acggcttccc aataacagta gcaggcccag cacccccacc attaatgtgc tggaatcaaa     1320

ggatacagac agtgataggg aagcagggac tgaaacgggg ggagagaaca atgataaaga     1380

agaagaagag aagaaagatg aaacttcgag ctcctctgaa gcaaattctc ggtgtcaaac     1440

accaataaag atgaagccaa atattgaacc tcctgagaat gtggagtgga gtggtgctga     1500

agcctcaatg tttagagtcc tcattggcac ttactatgac aatttctgtg ccattgctag     1560

gttaattggg accaaaacat gtagacaggt gtatgagttt agagtcaaag aatctagcat     1620

catagctcca gctcccgctg aggatgtgga tactcctcca aggaaaaaga agaggaaaca     1680

ccggttgtgg gctgcacact gcagaaagat acagctgaaa aaggacggct cctctaacca     1740

tgtttacaac tatcaaccct gtgatcatcc acggcagcct tgtgacagtt cgtgcccttg     1800

tgtgatagca caaaattttt gtgaaaagtt ttgtcaatgt agttcagagt gtcaaaaccg     1860

ctttccggga tgccgctgca aagcacagtg caacaccaag cagtgcccgt gctacctggc     1920

tgtccgagag tgtgaccctg acctctgtct tacttgtgga gccgctgacc attgggacag     1980

taaaaatgtg tcctgcaaga actgcagtat tcagcggggc tccaaaaagc atctattgct     2040

ggcaccatct gacgtggcag gctgggggat ttttatcaaa gatcctgtgc agaaaaatga     2100

attcatctca gaatactgtg gagagattat ttctcaagat gaagctgaca gaagagggaa     2160

agtgtatgat aaatacatgt gcagctttct gttcaacttg aacaatgatt ttgtggtgga     2220

tgcaacccgc aagggtaaca aaattcgttt tgcaaatcat tcggtaaatc caaactgcta     2280

tgcaaaagtt atgatggtta acggtgatca caggataggt atttttgcca agagagccat     2340

ccagactggc gaagagctgt tttttgatta cagatacagc caggctgatg ccctgaagta     2400

tgtcggcatc gaaagagaaa tggaaatccc ttgacatctg ctacctcctc ccccctcctc     2460

tgaaacagct gccttagctt caggaacctc gagtactgtg ggcaatttag aaaaagaaca     2520

tgcagtttga aattctgaat ttgcaaagta ctgtaagaat aatttatagt aatgagttta     2580

aaaatcaact ttttattgcc ttctcaccag ctgcaaagtg ttttgtacca gtgaattttt     2640

gcaataatgc agtatggtac atttttcaac tttgaataaa gaatacttga acttgtcctt     2700

gttgaatc                                                              2708


<210> 10
<211> 746
<212> PRT
<213> Homo sapiens

<400> 10
Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile 
                85                  90                  95      


Pro Leu Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser 
            100                 105                 110         


Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val Leu 
        115                 120                 125             


His Asn Ile Pro Tyr Met Gly Asp Glu Val Leu Asp Gln Asp Gly Thr 
    130                 135                 140                 


Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp Gly Lys Val His Gly Asp 
145                 150                 155                 160 


Arg Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn 
                165                 170                 175     


Ala Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp 
            180                 185                 190         


Pro Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp 
        195                 200                 205             


Asp Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe 
    210                 215                 220                 


Glu Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu 
225                 230                 235                 240 


Lys Glu Lys Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu 
                245                 250                 255     


Pro Pro Glu Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val 
            260                 265                 270         


Gln Arg Glu Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg 
        275                 280                 285             


Cys Phe Lys Tyr Asp Cys Phe Leu His Pro Phe His Ala Thr Pro Asn 
    290                 295                 300                 


Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala Leu Asp Asn Lys Pro Cys 
305                 310                 315                 320 


Gly Pro Gln Cys Tyr Gln His Leu Glu Gly Ala Lys Glu Phe Ala Ala 
                325                 330                 335     


Ala Leu Thr Ala Glu Arg Ile Lys Thr Pro Pro Lys Arg Pro Gly Gly 
            340                 345                 350         


Arg Arg Arg Gly Arg Leu Pro Asn Asn Ser Ser Arg Pro Ser Thr Pro 
        355                 360                 365             


Thr Ile Asn Val Leu Glu Ser Lys Asp Thr Asp Ser Asp Arg Glu Ala 
    370                 375                 380                 


Gly Thr Glu Thr Gly Gly Glu Asn Asn Asp Lys Glu Glu Glu Glu Lys 
385                 390                 395                 400 


Lys Asp Glu Thr Ser Ser Ser Ser Glu Ala Asn Ser Arg Cys Gln Thr 
                405                 410                 415     


Pro Ile Lys Met Lys Pro Asn Ile Glu Pro Pro Glu Asn Val Glu Trp 
            420                 425                 430         


Ser Gly Ala Glu Ala Ser Met Phe Arg Val Leu Ile Gly Thr Tyr Tyr 
        435                 440                 445             


Asp Asn Phe Cys Ala Ile Ala Arg Leu Ile Gly Thr Lys Thr Cys Arg 
    450                 455                 460                 


Gln Val Tyr Glu Phe Arg Val Lys Glu Ser Ser Ile Ile Ala Pro Ala 
465                 470                 475                 480 


Pro Ala Glu Asp Val Asp Thr Pro Pro Arg Lys Lys Lys Arg Lys His 
                485                 490                 495     


Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln Leu Lys Lys Asp Gly 
            500                 505                 510         


Ser Ser Asn His Val Tyr Asn Tyr Gln Pro Cys Asp His Pro Arg Gln 
        515                 520                 525             


Pro Cys Asp Ser Ser Cys Pro Cys Val Ile Ala Gln Asn Phe Cys Glu 
    530                 535                 540                 


Lys Phe Cys Gln Cys Ser Ser Glu Cys Gln Asn Arg Phe Pro Gly Cys 
545                 550                 555                 560 


Arg Cys Lys Ala Gln Cys Asn Thr Lys Gln Cys Pro Cys Tyr Leu Ala 
                565                 570                 575     


Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr Cys Gly Ala Ala Asp 
            580                 585                 590         


His Trp Asp Ser Lys Asn Val Ser Cys Lys Asn Cys Ser Ile Gln Arg 
        595                 600                 605             


Gly Ser Lys Lys His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly Trp 
    610                 615                 620                 


Gly Ile Phe Ile Lys Asp Pro Val Gln Lys Asn Glu Phe Ile Ser Glu 
625                 630                 635                 640 


Tyr Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly Lys 
                645                 650                 655     


Val Tyr Asp Lys Tyr Met Cys Ser Phe Leu Phe Asn Leu Asn Asn Asp 
            660                 665                 670         


Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys Ile Arg Phe Ala Asn 
        675                 680                 685             


His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val Met Met Val Asn Gly 
    690                 695                 700                 


Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala Ile Gln Thr Gly Glu 
705                 710                 715                 720 


Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala Asp Ala Leu Lys Tyr 
                725                 730                 735     


Val Gly Ile Glu Arg Glu Met Glu Ile Pro 
            740                 745     


<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
agcgatgacg tctctgaggt                                                   20


<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 12
gtacagggac accagccact                                                   20


<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
taacaagctc acgcagttgg                                                   20


<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
gttgagggca atgaggacat                                                   20


<210> 15
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
gcccgcaagc tgaccctgaa gttcattcaa gagatgaact tcagggtcag cttgctttt        59


<210> 16
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
ccggcggaaa tcttaaacca agaatctcga gattcttggt ttaagatttc cgttttt          57


<210> 17
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
ccgggctgag aatgtggaat acctactcga gtaggtattc cacattctca gcttttt          57


<210> 18
<211> 56
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
tttgtggata agcagcacaa gatttcaaga gaatcttctg ctgcttctcc attttt           56


<210> 19
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
tcatctgcac tgccaagact g                                                 21


<210> 20
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
catgccttct ttcactttgc c                                                 21


<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
aggagtttgc tgctgctctc                                                   20


<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
ccgagaattt gcttcagagg                                                   20


<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
tacggctcct attgccaaac                                                   20


<210> 24
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
tgcttcagtt tgttgccttg                                                   20


<210> 25
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
ggcctctgat ctccgatttc                                                   20


<210> 26
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
tgggctctaa attggctcac                                                   20


<210> 27
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
atgaaattca ccccctttcc                                                   20


<210> 28
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 28
ccctaggctg tgctcacttc                                                   20


<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
ccggctaact ctgaggacac                                                   20


<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 30
cgagctgttt acgtttgacg                                                   20


<210> 31
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: "DEAD" box motif peptide

<400> 31
Asp Glu Ala Asp 
1               


<210> 32
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
ccggtattgc cttctcacca gctgcctcga ggcagctggt gagaaggcaa tattttt          57


<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 33
tcgagccata aaaggcaact                                                   20


<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 34
tctccctcct cctcttcctc                                                   20


<210> 35
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 35
ccttgtagat tggggctgag                                                   20


<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 36
agtttggggg tggaagaaag                                                   20


<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 37
ggctgagaca gagggaacac                                                   20


<210> 38
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 38
ccatctcagc ctcccaagta                                                   20


