               SEQUENCE LISTING

<110> Inova Fruit B.V.

<120> Gene and method for increasing disease resistance in perennial plants

<130> PCTP194496

<160> 53

<170> BiSSAP 1.2

<210> 1
<211> 1095
<212> PRT
<213> Malus sp.

<220> 
<223> Predicted protein encoded by Vr2-C gene

<400> 1
Met Thr Ala His Glu Ala Ser Ser Ser Ser Ser Ser Lys Ser Lys Leu 
1               5                   10                  15      
Trp Ser Tyr Asp Val Phe Leu Ser Phe Arg Gly Glu Asp Thr Arg Asn 
            20                  25                  30          
Gly Phe Thr Ser His Leu His Glu Ala Leu Lys Tyr Arg Gly Tyr His 
        35                  40                  45              
Val Phe Ile Asp Glu Asp Gly Leu Lys Arg Gly Glu Glu Ile Lys Glu 
    50                  55                  60                  
Lys Leu Phe Arg Ala Ile Glu Glu Ser Arg Ile Ser Ile Ile Val Phe 
65                  70                  75                  80  
Ser Lys Met Tyr Ala Asp Ser Ser Trp Cys Leu Asp Glu Leu Val Lys 
                85                  90                  95      
Ile Met Glu Cys Arg Asp Lys Leu Gly Gln His Val Leu Pro Ile Phe 
            100                 105                 110         
Tyr His Val Asp Pro Ser His Val Arg Lys Gln Asp Gly Asp Leu Ala 
        115                 120                 125             
Glu Ala Phe Gln Lys His Glu Lys Asp Ile Arg Glu Glu Lys Asp Asp 
    130                 135                 140                 
Glu Lys Arg Glu Ala Lys Gln Lys Arg Ala Glu Gln Trp Lys Gly Ala 
145                 150                 155                 160 
Leu Thr Lys Ala Ala Asp Leu Ser Gly His His Leu Lys Ser Thr His 
                165                 170                 175     
Asn Arg Glu Arg Arg Arg Asp Pro Leu Thr Glu Ala Ala Asn Leu Ser 
            180                 185                 190         
Asp His Gln Thr Thr Asp Asn Gly Ser Arg Lys Gly Lys Thr Phe Pro 
        195                 200                 205             
Leu Arg Ile Thr Thr Phe Asn Arg Cys Glu Ala Lys Phe Ile Lys Lys 
    210                 215                 220                 
Ile Val Asp Glu Asn Ile Trp Glu Trp Leu Pro Arg Thr Asn Glu Leu 
225                 230                 235                 240 
His Val Ala Lys His Pro Ile Gly Ile Lys Ser Arg Ile Gln Gly Ile 
                245                 250                 255     
Ile Ser Asp Leu Ser Ser Gly Gly Ser Asn Asp Val Leu Met Val Gly 
            260                 265                 270         
Ile Trp Gly Met Gly Gly Leu Gly Lys Thr Thr Val Ala Lys Ala Ile 
        275                 280                 285             
Tyr Asn Gln Ile His Arg Lys Phe Glu Phe Lys Ser Phe Leu Ala Asp 
    290                 295                 300                 
Val Ser Asp Ala Thr Ser Lys His Gly Leu Val Tyr Leu Gln Glu Lys 
305                 310                 315                 320 
Leu Ile Ser Asp Ile Leu Lys Gln Lys Ser Gly Ser Ser Asn Phe Asp 
                325                 330                 335     
Glu Gly Ile Asn Leu Ile Lys Gln His Leu Gln Arg Arg Arg Val Leu 
            340                 345                 350         
Val Ile Ile Asp Asn Ile Asp Asp Leu Lys Gln Leu Asp Ala Ile Ala 
        355                 360                 365             
Val Ser His His Cys Phe Gly Pro Gly Ser Arg Ile Ile Ile Thr Thr 
    370                 375                 380                 
Arg Asn Glu His Leu Leu Lys Gln Val Glu Val Asp Lys Thr Tyr Pro 
385                 390                 395                 400 
Leu Gln Glu Met Lys Lys Lys Glu Ala Leu Glu Leu Phe Ser Trp His 
                405                 410                 415     
Ala Phe Arg Lys Ser Tyr Pro Asn Glu Glu Tyr Leu Glu Val Ser Glu 
            420                 425                 430         
Lys Val Val Ser Tyr Cys Gly Gly Leu Pro Leu Ala Leu Glu Val Leu 
        435                 440                 445             
Gly Ser Phe Leu Phe Lys Arg Pro Ile Ala Glu Trp Lys Ser Gln Leu 
    450                 455                 460                 
Lys Lys Leu Glu Arg Thr Pro Asn Gly Glu Ile Ile Lys Pro Leu Lys 
465                 470                 475                 480 
Ile Ser Phe Glu Gly Leu Asp Asp Thr Glu Lys Ala Ile Phe Leu Asp 
                485                 490                 495     
Ile Ser Cys Phe Phe Ile Gly Arg Asp Lys Asp Tyr Val Ala Lys Val 
            500                 505                 510         
Leu Asp Gly Cys Gly Phe Phe Ala Thr Gly Gly Ile Ser Val Leu Arg 
        515                 520                 525             
Glu Arg Cys Leu Val Thr Val Glu Gly Asn Lys Leu Thr Met His Asp 
    530                 535                 540                 
Leu Leu Arg Glu Met Ala Arg Val Ile Ile Ser Glu Lys Ser Leu Asp 
545                 550                 555                 560 
Cys Pro Gly Lys Trp Ser Arg Leu Trp Asn Arg Gln Glu Val Thr Asp 
                565                 570                 575     
Val Leu Thr Asn Lys Ser Gly Thr Gly Glu Ile Glu Gly Leu Ala Leu 
            580                 585                 590         
Tyr Phe Pro Lys Glu Thr Lys Ile Ala Ser Phe Ser Thr Lys Ala Phe 
        595                 600                 605             
Ala Ile Met Lys Lys Leu Ser Leu Leu Ala Leu Leu Phe Arg Lys Glu 
    610                 615                 620                 
Thr Lys Ile Ala Ser Phe Ser Thr Lys Ala Phe Ala Lys Met Lys Lys 
625                 630                 635                 640 
Leu Arg Leu Leu Gln Leu Ser Asn Val Glu Leu Lys Gly Glu Tyr Lys 
                645                 650                 655     
His Leu Pro Lys Glu Leu Ile Trp Leu Arg Trp Glu Gly Cys Pro Leu 
            660                 665                 670         
Lys Ser Leu Pro Asp Asp Phe Phe Asn Gln Pro Arg Leu Val Val Leu 
        675                 680                 685             
Glu Met Gln Cys Ser Lys Leu Val Gln Val Trp Lys Gly Phe Lys Ser 
    690                 695                 700                 
Leu His Asn Leu Lys Thr Leu Asp Leu Ser Trp Ser Asp Ser Leu Gln 
705                 710                 715                 720 
Lys Ser Pro Asp Phe Ser Gln Val Pro Asn Leu Glu Glu Leu Ile Leu 
                725                 730                 735     
Glu Ala Cys Ile Asn Leu Ser Glu Ile His Pro Ser Ile Gly His Leu 
            740                 745                 750         
Lys Arg Leu Ser Leu Val Asn Leu Lys Trp Cys Asn Lys Leu Ile Ser 
        755                 760                 765             
Leu Pro Arg Asp Phe Tyr Lys Leu Lys Ser Val Glu Thr Leu Leu Leu 
    770                 775                 780                 
Asn Asn Ser Tyr Gln Phe Arg Glu Val His Glu Asp Ile Gly Glu Met 
785                 790                 795                 800 
Ile Ser Leu Arg Thr Leu Glu Ala Arg Gly Thr Ala Ile Arg Glu Val 
                805                 810                 815     
Pro Pro Ser Ile Val Gly Leu Lys Asn Leu Thr Arg Leu Ser Leu Glu 
            820                 825                 830         
Gly Thr Met Arg Gly Ile Gln Leu Pro His Ser Leu Arg Glu Ile Asp 
        835                 840                 845             
Leu Thr Tyr Gly Ala Leu Asp Asp Ala Ile Lys Asp Leu Gly Ser Leu 
    850                 855                 860                 
Ile Tyr Leu Gln His Leu His Leu Gln Gly Asn Asn Phe His Ser Leu 
865                 870                 875                 880 
Pro Asn Leu Ser Gly Leu Leu Lys Leu Glu Thr Leu Trp Leu Asn Gly 
                885                 890                 895     
Ser Glu Tyr Leu Arg Thr Ile Pro Asp Leu Pro Thr Asn Leu Lys Val 
            900                 905                 910         
Leu Phe Ala Asp Ala Cys Pro Ala Leu Glu Thr Met Pro Asp Phe Ser 
        915                 920                 925             
Glu Met Ser Asn Met Arg Thr Leu Asp Val Ser His Ser Ala Lys Leu 
    930                 935                 940                 
Thr Gly Val Pro Gly Leu Asp Lys Ser Leu Asn Ser Met Val Trp Leu 
945                 950                 955                 960 
Asp Met His Arg Cys Pro Asn Leu Thr Ala Asp Phe Arg Lys Asn Ile 
                965                 970                 975     
Leu Gln Gly Trp Thr Ser Cys Gly Phe Gly Gly Ile Ala Leu His Gly 
            980                 985                 990         
Asn Tyr Val Pro Asp Trp Phe Glu Phe Ile Asn Glu Gly Thr Lys Arg 
        995                 1000                1005            
Thr Lys Leu Arg Ala Tyr Lys Thr Lys Ala Ser Tyr Thr Ile Asp Glu 
    1010                1015                1020                
Asn Tyr Glu Asn Asp His Leu Trp Gln Gly Gln Phe Ser Asn Asn Glu 
1025                1030                1035                1040
Leu Asn Leu Gln Gly Gly Asp Lys Val Asp Ile Val Phe Glu Asn Leu 
                1045                1050                1055    
Asp Glu Asp Asp Ser Val Lys Met Met Arg Thr Gly Val Asn Leu Val 
            1060                1065                1070        
Trp Asp Lys Leu Met Lys Glu Asn Met His Asp Leu Gly Asp Thr Arg 
        1075                1080                1085            
Gly Arg Ile Ser Phe Gly Ile 
    1090                1095

<210> 2
<211> 10282
<212> DNA
<213> Malus sp.

<220> 
<221> source
<222> 1..10282
<223> /mol_type="unassigned DNA"
      /note="Vr2-C gene with predicted promoter, terminator, exons and introns"
      /organism="Malus sp."

<220> 
<221> CDS
<222> join(3963..4496,4597..4661,5976..6025,6224..7321,7533..7894,8016..8841,8933..9018,9145..9411)
<223> /transl_table=1

<220> 
<221> promoter
<222> 1..3962

<220> 
<221> terminator
<222> 9412..10282

<220> 
<221> intron
<222> join(4497..4596,4662..5975,6026..6223,7322..7532,7895..8015,8842..8932,9019..9144)

<220> 
<221> exon
<222> join(3963..4496,4597..4661,5976..6025,6224..7321,7533..7894,8016..8841,8933..9018,9145..9411)

<400> 2
tggttggttc ggtttaagac ttggtgcgaa tcaaactgaa ctatgattat ctctaccaaa     60

tgacttgtta catcaattga catattaatt catagtctaa aattgtaatt tgcctagggt    120

aatgattttc acactcttca tgttgtttat gcctactagt tctcctttat tttgttcaat    180

ataaaagaat ataacaaact caagtgcatg tggacaacaa gagattacag aaattcctct    240

tcgttctcat tcttttgtca tttataactg gtgcattact ccgtttatgt gtacaattca    300

atctataaag ggtatagact gttgatattt gtttgctatg tatataaaca attttatata    360

tggttttcta attcataagg ttgattgtga atattgttaa tagtcgctca ccaatgtgaa    420

ctgctctcca ccaaccagta tataacgaga gaaggaagtt cttgatgcaa tagttgctca    480

caagtcatgt cgattcgagt gaaaccatgc ttgtgtgcca tgcatatctc acctaaaaac    540

gatattattc gcatacaata acaataaata ttagattaat ctcaagtaca tggagatgaa    600

ggaagaattg tccgaactgt tcaaactaaa ccattttaag cagtttgtct tttaatatta    660

tgatctagtg atatttttct tcacttataa atgagaggtc ttaagttcga atctcatgaa    720

agatgagttc gatacaaatt tataccccca cccctaatgt aaatatatct tgtacaaaaa    780

ccaatccaag cagtttggtt tgacttttat aatgaagttt ttagattgaa ctaattcaaa    840

ttttaattag cttggcttgg ttggttcggt ttggcatatt tggaaactgc tgaaaaccaa    900

aactaatttg aacgatgatg ctacattgat tgttgtattg tttaagactt gggccgaatc    960

aaagtgaact acgcttatct ctacaaaatg caattcactt gctaaatcaa ttattattga   1020

taattgacat attaattcac aatcaaaaat tgtaatttcc ttagggtaat gatttttaca   1080

ctcttcatat tgtttatgcc tactagtttt cctttatttt gttcaataaa agaatataac   1140

aaactcaagt gcatgtggac aataagagaa tacataaatt ccttctcgtt cttgttcttt   1200

tgtcatttat aactgataca ttactccatc tatgtgtaca atcgcatcat aaaattccgg   1260

ttcaatttat aaagggtata tactgttgat atttgtttac tatgtatata aacaatttta   1320

tatatggttt tctaattctt atggtagatc gtgaatattg ttaatagtca cttaccaatg   1380

tcaattactc tccaccaacc agtatataac gagagaagaa agttcttgat gcaatagtcg   1440

ctcacaagtc atgtcgattc gagtgaaaac atgcatgtgt gccgtgcata tctcacctac   1500

aaacgatatt gttcgcgtac aataacaata aatattggat taatctcaag tttttttagt   1560

tcaacttaaa gtcataattg ttggacactt tcatatatcc gttaattttt cgtcataacc   1620

ttagttaact aatcacgtag cgtccacata gacaataact gaggccacat gtcaatatgg   1680

accataaata attttaaact tttgacatat ggttttgtac gtatgatcac gttgttctaa   1740

agcatgttga attatgtaaa tgcctttaca gtttggtcaa ttttattgaa atttcaaaca   1800

atatttttgt caaggtgtgc acatcgaaaa cacatggcca caaattccac caattattgg   1860

gtggattaga aggaccaaat taggaatgag tatatttgat ataaaatagg agtggatata   1920

attgaagata aaatgagaaa aagttggtta aaaatgatag acatgtgaac taaaggccta   1980

caaatgttct tgttagaaaa agacggaggg tcaatgtaaa aagggtaaag gaaaacctca   2040

taatacttgg aatttggaaa taaactttaa gaaaagacat ggagtactca aagatgactg   2100

aagacttggt gcaaatccaa acacaatagc gtttcaagag acatatagcc gatcccgctt   2160

agtgggataa gactttatcg cttttgtatt tggtggattg gaaggaatta ttgagttttt   2220

gcaactatat atgaaccagc cgttgtggtt ttacataatt caatgttggg ccttgggcat   2280

tatgttttgc cattaatatc ccaacgacat tgccaactac atatgaacta gcacgcttcg   2340

ctatggtata cttttccagc ggatgagata ggccttgggc attaaaagcg actgcatttt   2400

atggcagtac tcatttttac tttttataca tttttgttaa ttttttgtaa ttattatttt   2460

ttaatttatt tgatctgact atttaagatt aagaaggact tgtcaaaagg aaaaatgatt   2520

gtgtgaagaa attattttaa tgatgaagtg agagggtgag ataggattag atagtcacca   2580

gtattgatct ttcgcgtgtg gacgttgttt gacgcgaagc aagtatgaaa aacaaaacgt   2640

tgccacacga tctgggatgg acgattttat atcaacttaa tggacgtgga tgacttttgc   2700

ttttgttgat tgaaggagct tgacctggat tttgatattt caatatgtac ccaccacaga   2760

agttgccaat gatgtcgatc gtattcatat atgaatcttt tgtgaaactt caatcttagc   2820

catcaacgca ttttttttgg actttctgtt accttatttt cttagcataa tattttataa   2880

tattgatata gaaattatgt aaaaaaatga agtagtcgag agttgatgta aaatcctatt   2940

ttgagagtct ctttgttcct tcaaaagcag ctcctgcatg cttttccaca gtccaattac   3000

gtgtccgtag ggttacatga ccatttttgt ctccctgagc ccaagtttca aaagccgccg   3060

acgactcgaa ttcctcgcaa aatcgtccat actgctttta gtaacgtcct tacctgataa   3120

ataaataaaa aaacacaaac gaaagaccac atttttcttt ctctttatct attttctcag   3180

caaccaaacg gaaaacaaga acaccgttgg tgacctccgg atttgagagg actttcgaag   3240

cgcatgcggg tagggcaagg acctggcgga gatggatttg aggtccatgt tggtgagctt   3300

cgcttccact gaaatcaaca ccgtacgcgt gtcgtcggaa aaggcggact ggatcaggat   3360

catccattaa cttgttcgat gtcgccgaag caccaccctc tgtttcttag gtttcgattg   3420

cggcgtcgga actccccttc atttttttta gcgcctgttt gccgtgttgt ttgatttggg   3480

gtttttctaa ttttgcaacg gaaaacggct aatgtacggt acagtcccaa ataggtcatg   3540

aaacggggag atccggggag gatcactttg ggtgggaaag atccggaaag gatctctttc   3600

catgttcaat aatgtaaatg ccttagcagt aatttcaaac aatatttttg tcaaggcgtg   3660

cacatcgaaa gcacatagcc acaaattcca ccaataattt attgaaatat caaacaatat   3720

tttattgaaa tttcctttct ttcctgcttt ccaccgtcct attacgtgtc ggtagtctgt   3780

cccttcgtgt tcctttcttt cctttttgcc tctctctttc cttgcacctt cctgcccggt   3840

gatttgtcgt ttctcaagtc catccaacat tattattttt cttcagcaac ctaaccacaa   3900

ccattgccat tttttcagtc tctgatctaa accattgcag tgtcataacg gtggataccg   3960

cc atg aca gcc cac gaa gcc tcc tct tcg tcc tcc tct aag tca aaa      4007
   Met Thr Ala His Glu Ala Ser Ser Ser Ser Ser Ser Lys Ser Lys 
   1               5                   10                  15  

ctt tgg agt tac gac gtg ttc ttg agc ttc aga ggc gaa gac acg cgg     4055
Leu Trp Ser Tyr Asp Val Phe Leu Ser Phe Arg Gly Glu Asp Thr Arg 
                20                  25                  30      

aat ggc ttc acc agc cac ctc cac gag gca tta aaa tac aga gga tac     4103
Asn Gly Phe Thr Ser His Leu His Glu Ala Leu Lys Tyr Arg Gly Tyr 
            35                  40                  45          

cat gtc ttt att gat gag gac ggt cta aaa aga ggg gaa gaa ata aaa     4151
His Val Phe Ile Asp Glu Asp Gly Leu Lys Arg Gly Glu Glu Ile Lys 
        50                  55                  60              

gag aaa ctg ttt cgt gca atc gaa gag tcg agg atc tct atc att gtc     4199
Glu Lys Leu Phe Arg Ala Ile Glu Glu Ser Arg Ile Ser Ile Ile Val 
    65                  70                  75                  

ttc tca aag atg tat gcg gat tcc agt tgg tgt ctt gac gag ctg gtg     4247
Phe Ser Lys Met Tyr Ala Asp Ser Ser Trp Cys Leu Asp Glu Leu Val 
80                  85                  90                  95  

aag atc atg gaa tgc aga gac aag ctg ggg caa cat gtt ttg cca ata     4295
Lys Ile Met Glu Cys Arg Asp Lys Leu Gly Gln His Val Leu Pro Ile 
                100                 105                 110     

ttc tat cac gtt gat cct tcc cat gtc agg aag cag gac gga gat tta     4343
Phe Tyr His Val Asp Pro Ser His Val Arg Lys Gln Asp Gly Asp Leu 
            115                 120                 125         

gcc gaa gca ttt cag aaa cac gaa aag gac atc cgt gaa gaa aaa gat     4391
Ala Glu Ala Phe Gln Lys His Glu Lys Asp Ile Arg Glu Glu Lys Asp 
        130                 135                 140             

gac gag aaa cgt gaa gct aaa caa aaa agg gca gag cag tgg aaa ggg     4439
Asp Glu Lys Arg Glu Ala Lys Gln Lys Arg Ala Glu Gln Trp Lys Gly 
    145                 150                 155                 

gct ctc aca aaa gct gca gat ttg tct ggc cac cat ctt aaa tcc act     4487
Ala Leu Thr Lys Ala Ala Asp Leu Ser Gly His His Leu Lys Ser Thr 
160                 165                 170                 175 

cat aat agg taatcattca actgctgttc aagatttaag ttgtattact             4536
His Asn Arg                                          
                                                        

ctaattaaca tgcttaatta atacacctta atctctcacg ttgatccttc gcatgtcagg   4596

gag agg cgg aga gat cct ctt acc gaa gct gca aat ttg tct gac cac     4644
Glu Arg Arg Arg Asp Pro Leu Thr Glu Ala Ala Asn Leu Ser Asp His
    180                 185                 190              

cag aca act gac aac gg  gtaatctttc acttgcgttt caagatttga            4691
Gln Thr Thr Asp Asn Gly                            
195                 200                            

aacattttag tgaatgactt aatctctcaa ttaattaaca tgctcaatta acattttaca   4751

taatccaaac attgattcac aggcttaatg aatacacttt aatctctcat ataaaaccta   4811

aaccgttatt ggagtttaat tcatacacaa cttttattta acaatgaatg actttctttc   4871

ttttattcta gtcacatact atctagttgc tagttagcat atatatatag gaaaaattag   4931

attttcatct cttattttta tattgcatcg attgaaactt tattattttt ttatttttga   4991

tcaaggtcct tcgaccttgt ccacatcatc attttagaat ttgaaaaatt agacgtcaac   5051

actttgctaa ttatttatag tttttagtta aggtattagc cctttttttg ttgaaattaa   5111

tattaattgc tttgtccaga ttttaagttg ataattgaaa tatcatctct tcccacattt   5171

aagtcaaata aacagtcatt tatactcctc cattcttttt cattcctcac gcacatgacc   5231

tctaaactca atccatcatg cttgttcatt gtcgagacgc caaccattat atttatgtag   5291

tcaacttttt ttcttctttt tgttttttat tttcctttta ttattaaata ttaatcttct   5351

tcttttttaa agaatattga atattaatac tgattgttaa atatatggtt ggctatactt   5411

ttgtatttca tgggtacaat tttattttac attttatttc attctaatat atctattggt   5471

acaatatatt ttgtgagtac aatttcgtta tacatattga tatgggtact attatttttt   5531

ttggagaaaa ttaggtaaaa tggttgtggt tgcagtattt tttatgtacc atacttatgc   5591

ttactaaaca ttgtgaaaca ttctttgaca aataaaaaaa ataaataaac aatgtggaac   5651

attcttttcc ttgagttgtt tacatgtacc catgagtttt catgcttcat ggacgtttca   5711

aatatcttct tttattttaa gcgtacctga ttagcagaaa acgaataagc cttcgaattt   5771

ggtggatgat agtctcattc ttcgatgcgt caattcctca gcttctggca agagcgtgtt   5831

aataacatgt tgtaagccta tttgattgag tgatcgaggg ttagagagag agagagaaag   5891

gaggtgcggc aatattgagg gagaagagag attgatttaa ttgtgaagtt tgtttgattc   5951

acccaattgt gtctttattt atag t agt aga aag ggt aaa aca ttt ccc ctt    6003
                             Ser Arg Lys Gly Lys Thr Phe Pro Leu
                                             205           

agg att aca aca ttt aat agg t aatctaatcc taataggaat ataagataca      6055
Arg Ile Thr Thr Phe Asn Arg                              
210                 215                                  

ttcccagatt ctctaggatt tacacaatca cattcctatt ctaaatatga ctacaacata   6115

tatatatata tatatatatg aagaaaagaa agaaaattgt ttatgtattg atatctccta   6175

cagagcctca ttgagtcaca ctaatgcttc tgaattcaat tttcaggt gc  gaa gca    6231
                                                     Cys Glu Ala
                                                                 

aag ttc att aaa aaa att gtt gac gag aat att tgg gaa tgg ctc ccc     6279
Lys Phe Ile Lys Lys Ile Val Asp Glu Asn Ile Trp Glu Trp Leu Pro
220                 225                 230                 235

aga aca aac gaa tta cat gtg gcc aag cac cca att gga atc aaa tct     6327
Arg Thr Asn Glu Leu His Val Ala Lys His Pro Ile Gly Ile Lys Ser
                240                 245                 250                

cgc att caa ggt att atc agt gat ctt tca agt ggt gga tca aat gat     6375
Arg Ile Gln Gly Ile Ile Ser Asp Leu Ser Ser Gly Gly Ser Asn Asp
            255                 260                 265

gtt ctc atg gtt gga att tgg ggg atg ggt gga ttg ggt aaa aca aca     6423
Val Leu Met Val Gly Ile Trp Gly Met Gly Gly Leu Gly Lys Thr Thr
        270                 275                 280    

gtt gcc aaa gcc att tat aac caa att cat cgt aag ttt gaa ttc aaa     6471
Val Ala Lys Ala Ile Tyr Asn Gln Ile His Arg Lys Phe Glu Phe Lys
    285                 290                 295        

agt ttc ctt gcc gac gtt agc gac gct aca agt aaa cat ggt cta gtt     6519
Ser Phe Leu Ala Asp Val Ser Asp Ala Thr Ser Lys His Gly Leu Val
300                 305                 310                 315

tat ttg caa gaa aaa ctt att tct gac atc ttg aaa cag aag tct gga     6567
Tyr Leu Gln Glu Lys Leu Ile Ser Asp Ile Leu Lys Gln Lys Ser Gly
                320                 325                 330

tca agc aat ttt gat gaa ggt atc aat ttg ata aaa caa cat ctc caa     6615
Ser Ser Asn Phe Asp Glu Gly Ile Asn Leu Ile Lys Gln His Leu Gln
            335                 340                 345

cgt aga agg gta ctt gtc atc atc gac aat ata gat gac ttg aaa caa     6663
Arg Arg Arg Val Leu Val Ile Ile Asp Asn Ile Asp Asp Leu Lys Gln
        350                 355                 360    

cta gat gca ata gct gta agt cac cat tgt ttt ggt cca gga agt aga     6711
Leu Asp Ala Ile Ala Val Ser His His Cys Phe Gly Pro Gly Ser Arg
    365                 370                 375        

att att ata aca aca cga aat gaa cat ttg cta aag caa gtg gaa gtg     6759
Ile Ile Ile Thr Thr Arg Asn Glu His Leu Leu Lys Gln Val Glu Val
380                 385                 390                 395

gac aag aca tat ccg ctt cag gaa atg aaa aag aaa gaa gcc ctg gag     6807
Asp Lys Thr Tyr Pro Leu Gln Glu Met Lys Lys Lys Glu Ala Leu Glu
                400                 405                 410 

ctc ttt agt tgg cat gcc ttt cga aaa agt tac cct aat gaa gaa tat     6855
Leu Phe Ser Trp His Ala Phe Arg Lys Ser Tyr Pro Asn Glu Glu Tyr
            415                 420                 425

ctt gaa gtc tca gaa aag gtt gtt tct tac tgt gga ggt ttg cca cta     6903
Leu Glu Val Ser Glu Lys Val Val Ser Tyr Cys Gly Gly Leu Pro Leu
        430                 435                 440    

gca ctt gaa gtt tta ggc tct ttt ttg ttt aaa aga cct att gca gag     6951
Ala Leu Glu Val Leu Gly Ser Phe Leu Phe Lys Arg Pro Ile Ala Glu
    445                 450                 455        

tgg aaa agt caa ttg aag aaa ttg gaa aga act cct aat gga gaa ata     6999
Trp Lys Ser Gln Leu Lys Lys Leu Glu Arg Thr Pro Asn Gly Glu Ile
460                 465                 470                 475  

ata aaa cca cta aaa ata agc ttt gaa ggg cta gat gat aca gag aag     7047
Ile Lys Pro Leu Lys Ile Ser Phe Glu Gly Leu Asp Asp Thr Glu Lys
                480                 485                 490 

gct ata ttc ctt gac ata tct tgt ttc ttt att gga agg gac aag gac     7095
Ala Ile Phe Leu Asp Ile Ser Cys Phe Phe Ile Gly Arg Asp Lys Asp
            495                 500                 505

tac gtt gca aaa gta tta gat gga tgt gga ttt ttt gca aca gga gga     7143
Tyr Val Ala Lys Val Leu Asp Gly Cys Gly Phe Phe Ala Thr Gly Gly
        510                 515                 520    

atc agt gtc ctc cgc gaa cga tgt ctt gta act gtt gaa ggc aac aag     7191
Ile Ser Val Leu Arg Glu Arg Cys Leu Val Thr Val Glu Gly Asn Lys
    525                 530                 535        

ttg act atg cat gat ttg ctt cga gaa atg gcc aga gta atc att tct     7239
Leu Thr Met His Asp Leu Leu Arg Glu Met Ala Arg Val Ile Ile Ser
540                 545                 550                 555

gaa aaa tct ctt gat tgc cct gga aaa tgg agt agg ttg tgg aat cgt     7287
Glu Lys Ser Leu Asp Cys Pro Gly Lys Trp Ser Arg Leu Trp Asn Arg
                560                 565                 570    

caa gag gtc act gat gta ttg aca aat aaa tct g tgagtttatt            7331
Gln Glu Val Thr Asp Val Leu Thr Asn Lys Ser     
            575                 580             

cccaataaat tttggattta tgcatcatac aagaaaagca tagatgtaac cctcgcaagt   7391

caattataca ttaaacaaga ttcatgtgta aatatattca ccgtgcgtga ttttgcgtaa   7451

tgaataataa taatacatgt aaacatatgc aaatataccg tttcttacca ctataacatt   7511

tttttttttt ttgttaacag g ga  act gga gaa att gaa gga ctt gct cta     7561
                        Gly Thr Gly Glu Ile Glu Gly Leu Ala Leu
                                585                 590

tat ttc cct aaa gaa act aag att gct agt ttc agt aca aaa gca ttt     7609
Tyr Phe Pro Lys Glu Thr Lys Ile Ala Ser Phe Ser Thr Lys Ala Phe
        595                 600                 605 

gcc ata atg aag aaa ctg agc ctg ctt gct cta ctt ttc cgt aaa gaa     7657
Ala Ile Met Lys Lys Leu Ser Leu Leu Ala Leu Leu Phe Arg Lys Glu
    610                 615                 620     

act aag att gct agt ttc agt aca aaa gca ttt gcc aaa atg aag aaa     7705
Thr Lys Ile Ala Ser Phe Ser Thr Lys Ala Phe Ala Lys Met Lys Lys
625                 630                 635                 640

ctg aga ctg ctt cag ctc agc aac gta gag ctc aaa gga gaa tac aaa     7753
Leu Arg Leu Leu Gln Leu Ser Asn Val Glu Leu Lys Gly Glu Tyr Lys
                645                 650                 655

cat ctt ccc aaa gag tta ata tgg ttg cgt tgg gaa gga tgc cct tta     7801
His Leu Pro Lys Glu Leu Ile Trp Leu Arg Trp Glu Gly Cys Pro Leu
            660                 665                 670

aag tcc tta cca gat gac ttt ttt aat caa cca aga cta gtt gtt tta     7849
Lys Ser Leu Pro Asp Asp Phe Phe Asn Gln Pro Arg Leu Val Val Leu
        675                 680                 685 

gag atg cag tgt agc aaa ctg gta caa gtt tgg aag ggt ttc aag         7894
Glu Met Gln Cys Ser Lys Leu Val Gln Val Trp Lys Gly Phe Lys
    690                 695                 700 

gtacaatgaa ttacacctga tgatgttctg ttcctatttg ttttttggat ttcttaactt   7954
                                                    
                                                                  

ttttttgtaa catcttcatt ttggatatta atttcaattt tcttttgatt ttctgcaaca   8014

g tcg cta cat aac ttg aaa acc ctt gat ctc agc tgg tct gat tcc tta   8063
  Ser Leu His Asn Leu Lys Thr Leu Asp Leu Ser Trp Ser Asp Ser Leu
      705                 710                 715  

cag aaa tca ccg gac ttt tca caa gtc cca aat ctt gaa gag ttg ata     8111
Gln Lys Ser Pro Asp Phe Ser Gln Val Pro Asn Leu Glu Glu Leu Ile
720                 725                 730                 735

ttg gaa gcc tgt att aat ctg tcc gag att cac ccc tcc att ggt cat     8159
Leu Glu Ala Cys Ile Asn Leu Ser Glu Ile His Pro Ser Ile Gly His
                740                 745                 750

ctt aaa aga ctt tct ttg gtg aac ctt aag tgg tgt aat aag ctt att     8207
Leu Lys Arg Leu Ser Leu Val Asn Leu Lys Trp Cys Asn Lys Leu Ile
            755                 760                 765

tct ctt cca agg gat ttc tat aag ttg aaa tct gtt gag act ctt ctt     8255
Ser Leu Pro Arg Asp Phe Tyr Lys Leu Lys Ser Val Glu Thr Leu Leu
        770                 775                 780

ctt aat aat tct tat caa ttc aga gaa gtg cat gag gat ata ggg gag     8303
Leu Asn Asn Ser Tyr Gln Phe Arg Glu Val His Glu Asp Ile Gly Glu
    785                 790                 795  

atg ata tca ctg aga aca ctt gaa gca agg ggt aca gcc ata aga gaa     8351
Met Ile Ser Leu Arg Thr Leu Glu Ala Arg Gly Thr Ala Ile Arg Glu
800                 805                 810                 815

gta cca cct tcc ata gta gga ttg aag aat ctc act cgt tta tct ctg     8399
Val Pro Pro Ser Ile Val Gly Leu Lys Asn Leu Thr Arg Leu Ser Leu
                820                 825                 830

gag ggt act atg agg ggt att caa ttg ccc cat tcg tta aga gaa atc     8447
Glu Gly Thr Met Arg Gly Ile Gln Leu Pro His Ser Leu Arg Glu Ile
            835                 840                 845

gat ctc aca tac ggc gca tta gat gat gca att aag gat ctt ggc agt     8495
Asp Leu Thr Tyr Gly Ala Leu Asp Asp Ala Ile Lys Asp Leu Gly Ser
        850                 855                 860

cta att tat tta caa cat ttg cat ctt caa ggt aat aac ttt cat agc     8543
Leu Ile Tyr Leu Gln His Leu His Leu Gln Gly Asn Asn Phe His Ser
    865                 870                 875  

tta cca aac ctc agt ggt ctt tta aag ctc gaa aca ttg tgg tta aat     8591
Leu Pro Asn Leu Ser Gly Leu Leu Lys Leu Glu Thr Leu Trp Leu Asn
880                 885                 890                 895

gga agc gaa tat ctt cgt aca atc cct gat tta cca aca aat ttg aaa     8639
Gly Ser Glu Tyr Leu Arg Thr Ile Pro Asp Leu Pro Thr Asn Leu Lys
                900                 905                 910

gtt ctg ttt gcc gat gct tgc cct gca ttg gaa aca atg ccg gac ttt     8687
Val Leu Phe Ala Asp Ala Cys Pro Ala Leu Glu Thr Met Pro Asp Phe
            915                 920                 925

tcg gaa atg tca aat atg aga aca ctg gat gta agt cat tca gcc aaa     8735
Ser Glu Met Ser Asn Met Arg Thr Leu Asp Val Ser His Ser Ala Lys
        930                 935                 940

ctc act ggg gtt cca ggc ttg gat aag tca tta aac tcc atg gtg tgg     8783
Leu Thr Gly Val Pro Gly Leu Asp Lys Ser Leu Asn Ser Met Val Trp
    945                 950                 955  

ctt gat atg cat cgc tgc ccc aat ctc aca gct gat ttt agg aag aac     8831
Leu Asp Met His Arg Cys Pro Asn Leu Thr Ala Asp Phe Arg Lys Asn
960                 965                 970                 975

atc cta cag g tatgtctctc tccctatcat tgccttccta tcgtgcgcat           8881
Ile Leu Gln                                
           

acatgtgtat atatatatat atatatgtga cacttgtatt gcatatatag g ga tgg     8937
                                                        Gly Trp
                                                            980

act tct tgc gga ttt ggt ggc att gct ctc cat ggg aat tat gtt cct     8985
Thr Ser Cys Gly Phe Gly Gly Ile Ala Leu His Gly Asn Tyr Val Pro
                985                 990                 995

gat tgg ttt gag ttt atc aac gag ggc act aaa gtcagttttg atattccccc   9038
Asp Trp Phe Glu Phe Ile Asn Glu Gly Thr Lys  
            1000                1005            

gaccgatgat cgtaattttg acgggctaac tctattctgc ttgttccgcg tatgcaaaaa   9098

aaaaagatta cctcatcttg acattaatgt tataattaat accaag cgt acg aag      9153
                                                   Arg Thr Lys
                                                           1010

ttg cgg gcc tac aaa acc aaa gcc tca tat acg atc gat gag aat tat     9201
Leu Arg Ala Tyr Lys Thr Lys Ala Ser Tyr Thr Ile Asp Glu Asn Tyr
                1015                1020                1025

gaa aac gat cat ctt tgg cag gga caa ttc tca aac aat gag ctc aat     9249
Glu Asn Asp His Leu Trp Gln Gly Gln Phe Ser Asn Asn Glu Leu Asn
            1030                1035                1040

ttg caa ggt ggg gat aaa gtt gat ata gtt ttt gaa aat cta gat gaa     9297
Leu Gln Gly Gly Asp Lys Val Asp Ile Val Phe Glu Asn Leu Aso Glu
        1045                1050                1055

gat gat tct gtt aaa atg atg aga aca ggg gtt aat cta gta tgg gac     9345
Asp Asp Ser Val Lys Met Met Arg Thr Gly Val Asn Leu Val Trp Asp
    1060                1065                1070

aaa ctt atg aag gaa aat atg cat gat ttg ggc gac act aga ggt aga     9393
Lys Leu Met Lys Glu Asn Met His Asp Leu Gly Asp Thr Arg Gly Arg 
1075                1080                1085                1090

atc agt ttt ggc atc tga taaactcgtt tgtgcagaat gaaggtgaaa            9441
Ile Ser Phe Gly Ile                 
                1095                

gcatcacaat caattcgtca aacacctcac catttttcgc tttcctagtt cgataatgga   9501

ggcgaatcca tatttcatgc ttttattttt tcagattcct atgatttttt caattagttg   9561

ttttggattt tgaatttatt gcatcaagta acatttcaac attacagcaa tcaatataat   9621

cttccgccac atattcaagg aatttacttt taaggataga aagaaaatca atgatagcct   9681

caagatgcca gtcaatggtt tctactacct tttcattaat cttgacttgc cttgacatgt   9741

tagcagaaga ttgactctac atttactaaa agatttatta ccttttctaa tacctttgca   9801

gtcaatgaac tcgtttgcgc aataaaaata tagtcttatg ttggattctc caaaacttta   9861

gaagcaagtt gtttgaaaga ttgtagagct gttcctttta agataaaaaa aaatctcatt   9921

tgcaagactc agaaatgatg gattgctcaa tagaatatct cggaaatttt ctccacttcc   9981

cttccacttt gactgatgag ttcataagct tccttctccg attttagttt ctactagtga  10041

tgctgcaggt tttaaaacca tataaagcat gtcaaaagtt ccaagtatat atacgatatg  10101

caatatttac atacatgtga ttcatgtctt cttaaccatt aacagaacaa actgaaaaaa  10161

agaaaagcaa aaatatgaat tgtacatgaa attgtgttca atcctaaaac tacacttcag  10221

aaggataaat atacatgcgc tctgcaattt catttctcag ttctaccatt gccacttatt  10281

c                                                                  10282

<210> 3
<211> 3288
<212> DNA
<213> Malus sp.

<220> 
<221> source
<222> 1..3288
<223> /mol_type="unassigned DNA"
      /note="Predicted coding sequence of Vr2-C"
      /organism="Malus sp."

<220> 
<221> CDS
<222> 1..3288
<223> /transl_table=1

<400> 3
atg aca gcc cac gaa gcc tcc tct tcg tcc tcc tct aag tca aaa ctt      48
Met Thr Ala His Glu Ala Ser Ser Ser Ser Ser Ser Lys Ser Lys Leu 
1               5                   10                  15      

tgg agt tac gac gtg ttc ttg agc ttc aga ggc gaa gac acg cgg aat      96
Trp Ser Tyr Asp Val Phe Leu Ser Phe Arg Gly Glu Asp Thr Arg Asn 
            20                  25                  30          

ggc ttc acc agc cac ctc cac gag gca tta aaa tac aga gga tac cat     144
Gly Phe Thr Ser His Leu His Glu Ala Leu Lys Tyr Arg Gly Tyr His 
        35                  40                  45              

gtc ttt att gat gag gac ggt cta aaa aga ggg gaa gaa ata aaa gag     192
Val Phe Ile Asp Glu Asp Gly Leu Lys Arg Gly Glu Glu Ile Lys Glu 
    50                  55                  60                  

aaa ctg ttt cgt gca atc gaa gag tcg agg atc tct atc att gtc ttc     240
Lys Leu Phe Arg Ala Ile Glu Glu Ser Arg Ile Ser Ile Ile Val Phe 
65                  70                  75                  80  

tca aag atg tat gcg gat tcc agt tgg tgt ctt gac gag ctg gtg aag     288
Ser Lys Met Tyr Ala Asp Ser Ser Trp Cys Leu Asp Glu Leu Val Lys 
                85                  90                  95      

atc atg gaa tgc aga gac aag ctg ggg caa cat gtt ttg cca ata ttc     336
Ile Met Glu Cys Arg Asp Lys Leu Gly Gln His Val Leu Pro Ile Phe 
            100                 105                 110         

tat cac gtt gat cct tcc cat gtc agg aag cag gac gga gat tta gcc     384
Tyr His Val Asp Pro Ser His Val Arg Lys Gln Asp Gly Asp Leu Ala 
        115                 120                 125             

gaa gca ttt cag aaa cac gaa aag gac atc cgt gaa gaa aaa gat gac     432
Glu Ala Phe Gln Lys His Glu Lys Asp Ile Arg Glu Glu Lys Asp Asp 
    130                 135                 140                 

gag aaa cgt gaa gct aaa caa aaa agg gca gag cag tgg aaa ggg gct     480
Glu Lys Arg Glu Ala Lys Gln Lys Arg Ala Glu Gln Trp Lys Gly Ala 
145                 150                 155                 160 

ctc aca aaa gct gca gat ttg tct ggc cac cat ctt aaa tcc act cat     528
Leu Thr Lys Ala Ala Asp Leu Ser Gly His His Leu Lys Ser Thr His 
                165                 170                 175     

aat agg gag agg cgg aga gat cct ctt acc gaa gct gca aat ttg tct     576
Asn Arg Glu Arg Arg Arg Asp Pro Leu Thr Glu Ala Ala Asn Leu Ser 
            180                 185                 190         

gac cac cag aca act gac aac ggt agt aga aag ggt aaa aca ttt ccc     624
Asp His Gln Thr Thr Asp Asn Gly Ser Arg Lys Gly Lys Thr Phe Pro 
        195                 200                 205             

ctt agg att aca aca ttt aat agg tgc gaa gca aag ttc att aaa aaa     672
Leu Arg Ile Thr Thr Phe Asn Arg Cys Glu Ala Lys Phe Ile Lys Lys 
    210                 215                 220                 

att gtt gac gag aat att tgg gaa tgg ctc ccc aga aca aac gaa tta     720
Ile Val Asp Glu Asn Ile Trp Glu Trp Leu Pro Arg Thr Asn Glu Leu 
225                 230                 235                 240 

cat gtg gcc aag cac cca att gga atc aaa tct cgc att caa ggt att     768
His Val Ala Lys His Pro Ile Gly Ile Lys Ser Arg Ile Gln Gly Ile 
                245                 250                 255     

atc agt gat ctt tca agt ggt gga tca aat gat gtt ctc atg gtt gga     816
Ile Ser Asp Leu Ser Ser Gly Gly Ser Asn Asp Val Leu Met Val Gly 
            260                 265                 270         

att tgg ggg atg ggt gga ttg ggt aaa aca aca gtt gcc aaa gcc att     864
Ile Trp Gly Met Gly Gly Leu Gly Lys Thr Thr Val Ala Lys Ala Ile 
        275                 280                 285             

tat aac caa att cat cgt aag ttt gaa ttc aaa agt ttc ctt gcc gac     912
Tyr Asn Gln Ile His Arg Lys Phe Glu Phe Lys Ser Phe Leu Ala Asp 
    290                 295                 300                 

gtt agc gac gct aca agt aaa cat ggt cta gtt tat ttg caa gaa aaa     960
Val Ser Asp Ala Thr Ser Lys His Gly Leu Val Tyr Leu Gln Glu Lys 
305                 310                 315                 320 

ctt att tct gac atc ttg aaa cag aag tct gga tca agc aat ttt gat    1008
Leu Ile Ser Asp Ile Leu Lys Gln Lys Ser Gly Ser Ser Asn Phe Asp 
                325                 330                 335     

gaa ggt atc aat ttg ata aaa caa cat ctc caa cgt aga agg gta ctt    1056
Glu Gly Ile Asn Leu Ile Lys Gln His Leu Gln Arg Arg Arg Val Leu 
            340                 345                 350         

gtc atc atc gac aat ata gat gac ttg aaa caa cta gat gca ata gct    1104
Val Ile Ile Asp Asn Ile Asp Asp Leu Lys Gln Leu Asp Ala Ile Ala 
        355                 360                 365             

gta agt cac cat tgt ttt ggt cca gga agt aga att att ata aca aca    1152
Val Ser His His Cys Phe Gly Pro Gly Ser Arg Ile Ile Ile Thr Thr 
    370                 375                 380                 

cga aat gaa cat ttg cta aag caa gtg gaa gtg gac aag aca tat ccg    1200
Arg Asn Glu His Leu Leu Lys Gln Val Glu Val Asp Lys Thr Tyr Pro 
385                 390                 395                 400 

ctt cag gaa atg aaa aag aaa gaa gcc ctg gag ctc ttt agt tgg cat    1248
Leu Gln Glu Met Lys Lys Lys Glu Ala Leu Glu Leu Phe Ser Trp His 
                405                 410                 415     

gcc ttt cga aaa agt tac cct aat gaa gaa tat ctt gaa gtc tca gaa    1296
Ala Phe Arg Lys Ser Tyr Pro Asn Glu Glu Tyr Leu Glu Val Ser Glu 
            420                 425                 430         

aag gtt gtt tct tac tgt gga ggt ttg cca cta gca ctt gaa gtt tta    1344
Lys Val Val Ser Tyr Cys Gly Gly Leu Pro Leu Ala Leu Glu Val Leu 
        435                 440                 445             

ggc tct ttt ttg ttt aaa aga cct att gca gag tgg aaa agt caa ttg    1392
Gly Ser Phe Leu Phe Lys Arg Pro Ile Ala Glu Trp Lys Ser Gln Leu 
    450                 455                 460                 

aag aaa ttg gaa aga act cct aat gga gaa ata ata aaa cca cta aaa    1440
Lys Lys Leu Glu Arg Thr Pro Asn Gly Glu Ile Ile Lys Pro Leu Lys 
465                 470                 475                 480 

ata agc ttt gaa ggg cta gat gat aca gag aag gct ata ttc ctt gac    1488
Ile Ser Phe Glu Gly Leu Asp Asp Thr Glu Lys Ala Ile Phe Leu Asp 
                485                 490                 495     

ata tct tgt ttc ttt att gga agg gac aag gac tac gtt gca aaa gta    1536
Ile Ser Cys Phe Phe Ile Gly Arg Asp Lys Asp Tyr Val Ala Lys Val 
            500                 505                 510         

tta gat gga tgt gga ttt ttt gca aca gga gga atc agt gtc ctc cgc    1584
Leu Asp Gly Cys Gly Phe Phe Ala Thr Gly Gly Ile Ser Val Leu Arg 
        515                 520                 525             

gaa cga tgt ctt gta act gtt gaa ggc aac aag ttg act atg cat gat    1632
Glu Arg Cys Leu Val Thr Val Glu Gly Asn Lys Leu Thr Met His Asp 
    530                 535                 540                 

ttg ctt cga gaa atg gcc aga gta atc att tct gaa aaa tct ctt gat    1680
Leu Leu Arg Glu Met Ala Arg Val Ile Ile Ser Glu Lys Ser Leu Asp 
545                 550                 555                 560 

tgc cct gga aaa tgg agt agg ttg tgg aat cgt caa gag gtc act gat    1728
Cys Pro Gly Lys Trp Ser Arg Leu Trp Asn Arg Gln Glu Val Thr Asp 
                565                 570                 575     

gta ttg aca aat aaa tct gga act gga gaa att gaa gga ctt gct cta    1776
Val Leu Thr Asn Lys Ser Gly Thr Gly Glu Ile Glu Gly Leu Ala Leu 
            580                 585                 590         

tat ttc cct aaa gaa act aag att gct agt ttc agt aca aaa gca ttt    1824
Tyr Phe Pro Lys Glu Thr Lys Ile Ala Ser Phe Ser Thr Lys Ala Phe 
        595                 600                 605             

gcc ata atg aag aaa ctg agc ctg ctt gct cta ctt ttc cgt aaa gaa    1872
Ala Ile Met Lys Lys Leu Ser Leu Leu Ala Leu Leu Phe Arg Lys Glu 
    610                 615                 620                 

act aag att gct agt ttc agt aca aaa gca ttt gcc aaa atg aag aaa    1920
Thr Lys Ile Ala Ser Phe Ser Thr Lys Ala Phe Ala Lys Met Lys Lys 
625                 630                 635                 640 

ctg aga ctg ctt cag ctc agc aac gta gag ctc aaa gga gaa tac aaa    1968
Leu Arg Leu Leu Gln Leu Ser Asn Val Glu Leu Lys Gly Glu Tyr Lys 
                645                 650                 655     

cat ctt ccc aaa gag tta ata tgg ttg cgt tgg gaa gga tgc cct tta    2016
His Leu Pro Lys Glu Leu Ile Trp Leu Arg Trp Glu Gly Cys Pro Leu 
            660                 665                 670         

aag tcc tta cca gat gac ttt ttt aat caa cca aga cta gtt gtt tta    2064
Lys Ser Leu Pro Asp Asp Phe Phe Asn Gln Pro Arg Leu Val Val Leu 
        675                 680                 685             

gag atg cag tgt agc aaa ctg gta caa gtt tgg aag ggt ttc aag tcg    2112
Glu Met Gln Cys Ser Lys Leu Val Gln Val Trp Lys Gly Phe Lys Ser 
    690                 695                 700                 

cta cat aac ttg aaa acc ctt gat ctc agc tgg tct gat tcc tta cag    2160
Leu His Asn Leu Lys Thr Leu Asp Leu Ser Trp Ser Asp Ser Leu Gln 
705                 710                 715                 720 

aaa tca ccg gac ttt tca caa gtc cca aat ctt gaa gag ttg ata ttg    2208
Lys Ser Pro Asp Phe Ser Gln Val Pro Asn Leu Glu Glu Leu Ile Leu 
                725                 730                 735     

gaa gcc tgt att aat ctg tcc gag att cac ccc tcc att ggt cat ctt    2256
Glu Ala Cys Ile Asn Leu Ser Glu Ile His Pro Ser Ile Gly His Leu 
            740                 745                 750         

aaa aga ctt tct ttg gtg aac ctt aag tgg tgt aat aag ctt att tct    2304
Lys Arg Leu Ser Leu Val Asn Leu Lys Trp Cys Asn Lys Leu Ile Ser 
        755                 760                 765             

ctt cca agg gat ttc tat aag ttg aaa tct gtt gag act ctt ctt ctt    2352
Leu Pro Arg Asp Phe Tyr Lys Leu Lys Ser Val Glu Thr Leu Leu Leu 
    770                 775                 780                 

aat aat tct tat caa ttc aga gaa gtg cat gag gat ata ggg gag atg    2400
Asn Asn Ser Tyr Gln Phe Arg Glu Val His Glu Asp Ile Gly Glu Met 
785                 790                 795                 800 

ata tca ctg aga aca ctt gaa gca agg ggt aca gcc ata aga gaa gta    2448
Ile Ser Leu Arg Thr Leu Glu Ala Arg Gly Thr Ala Ile Arg Glu Val 
                805                 810                 815     

cca cct tcc ata gta gga ttg aag aat ctc act cgt tta tct ctg gag    2496
Pro Pro Ser Ile Val Gly Leu Lys Asn Leu Thr Arg Leu Ser Leu Glu 
            820                 825                 830         

ggt act atg agg ggt att caa ttg ccc cat tcg tta aga gaa atc gat    2544
Gly Thr Met Arg Gly Ile Gln Leu Pro His Ser Leu Arg Glu Ile Asp 
        835                 840                 845             

ctc aca tac ggc gca tta gat gat gca att aag gat ctt ggc agt cta    2592
Leu Thr Tyr Gly Ala Leu Asp Asp Ala Ile Lys Asp Leu Gly Ser Leu 
    850                 855                 860                 

att tat tta caa cat ttg cat ctt caa ggt aat aac ttt cat agc tta    2640
Ile Tyr Leu Gln His Leu His Leu Gln Gly Asn Asn Phe His Ser Leu 
865                 870                 875                 880 

cca aac ctc agt ggt ctt tta aag ctc gaa aca ttg tgg tta aat gga    2688
Pro Asn Leu Ser Gly Leu Leu Lys Leu Glu Thr Leu Trp Leu Asn Gly 
                885                 890                 895     

agc gaa tat ctt cgt aca atc cct gat tta cca aca aat ttg aaa gtt    2736
Ser Glu Tyr Leu Arg Thr Ile Pro Asp Leu Pro Thr Asn Leu Lys Val 
            900                 905                 910         

ctg ttt gcc gat gct tgc cct gca ttg gaa aca atg ccg gac ttt tcg    2784
Leu Phe Ala Asp Ala Cys Pro Ala Leu Glu Thr Met Pro Asp Phe Ser 
        915                 920                 925             

gaa atg tca aat atg aga aca ctg gat gta agt cat tca gcc aaa ctc    2832
Glu Met Ser Asn Met Arg Thr Leu Asp Val Ser His Ser Ala Lys Leu 
    930                 935                 940                 

act ggg gtt cca ggc ttg gat aag tca tta aac tcc atg gtg tgg ctt    2880
Thr Gly Val Pro Gly Leu Asp Lys Ser Leu Asn Ser Met Val Trp Leu 
945                 950                 955                 960 

gat atg cat cgc tgc ccc aat ctc aca gct gat ttt agg aag aac atc    2928
Asp Met His Arg Cys Pro Asn Leu Thr Ala Asp Phe Arg Lys Asn Ile 
                965                 970                 975     

cta cag gga tgg act tct tgc gga ttt ggt ggc att gct ctc cat ggg    2976
Leu Gln Gly Trp Thr Ser Cys Gly Phe Gly Gly Ile Ala Leu His Gly 
            980                 985                 990         

aat tat gtt cct gat tgg ttt gag ttt atc aac gag ggc act aaa cgt    3024
Asn Tyr Val Pro Asp Trp Phe Glu Phe Ile Asn Glu Gly Thr Lys Arg 
        995                 1000                1005            

acg aag ttg cgg gcc tac aaa acc aaa gcc tca tat acg atc gat gag    3072
Thr Lys Leu Arg Ala Tyr Lys Thr Lys Ala Ser Tyr Thr Ile Asp Glu 
    1010                1015                1020                

aat tat gaa aac gat cat ctt tgg cag gga caa ttc tca aac aat gag    3120
Asn Tyr Glu Asn Asp His Leu Trp Gln Gly Gln Phe Ser Asn Asn Glu 
1025                1030                1035                1040

ctc aat ttg caa ggt ggg gat aaa gtt gat ata gtt ttt gaa aat cta    3168
Leu Asn Leu Gln Gly Gly Asp Lys Val Asp Ile Val Phe Glu Asn Leu 
                1045                1050                1055    

gat gaa gat gat tct gtt aaa atg atg aga aca ggg gtt aat cta gta    3216
Asp Glu Asp Asp Ser Val Lys Met Met Arg Thr Gly Val Asn Leu Val 
            1060                1065                1070        

tgg gac aaa ctt atg aag gaa aat atg cat gat ttg ggc gac act aga    3264
Trp Asp Lys Leu Met Lys Glu Asn Met His Asp Leu Gly Asp Thr Arg 
        1075                1080                1085            

ggt aga atc agt ttt ggc atc tga                                    3288
Gly Arg Ile Ser Phe Gly Ile     
    1090                1095     

<210> 4
<211> 232
<212> PRT
<213> Malus sp.

<220> 
<223> TIR domain of SEQ ID NO: 1

<400> 4
Met Thr Ala His Glu Ala Ser Ser Ser Ser Ser Ser Lys Ser Lys Leu 
1               5                   10                  15      
Trp Ser Tyr Asp Val Phe Leu Ser Phe Arg Gly Glu Asp Thr Arg Asn 
            20                  25                  30          
Gly Phe Thr Ser His Leu His Glu Ala Leu Lys Tyr Arg Gly Tyr His 
        35                  40                  45              
Val Phe Ile Asp Glu Asp Gly Leu Lys Arg Gly Glu Glu Ile Lys Glu 
    50                  55                  60                  
Lys Leu Phe Arg Ala Ile Glu Glu Ser Arg Ile Ser Ile Ile Val Phe 
65                  70                  75                  80  
Ser Lys Met Tyr Ala Asp Ser Ser Trp Cys Leu Asp Glu Leu Val Lys 
                85                  90                  95      
Ile Met Glu Cys Arg Asp Lys Leu Gly Gln His Val Leu Pro Ile Phe 
            100                 105                 110         
Tyr His Val Asp Pro Ser His Val Arg Lys Gln Asp Gly Asp Leu Ala 
        115                 120                 125             
Glu Ala Phe Gln Lys His Glu Lys Asp Ile Arg Glu Glu Lys Asp Asp 
    130                 135                 140                 
Glu Lys Arg Glu Ala Lys Gln Lys Arg Ala Glu Gln Trp Lys Gly Ala 
145                 150                 155                 160 
Leu Thr Lys Ala Ala Asp Leu Ser Gly His His Leu Lys Ser Thr His 
                165                 170                 175     
Asn Arg Cys Glu Ala Lys Phe Ile Lys Lys Ile Val Asp Glu Asn Ile 
            180                 185                 190         
Trp Glu Trp Leu Pro Arg Thr Asn Glu Leu His Val Ala Lys His Pro 
        195                 200                 205             
Ile Gly Ile Lys Ser Arg Ile Gln Gly Ile Ile Ser Asp Leu Ser Ser 
    210                 215                 220                 
Gly Gly Ser Asn Asp Val Leu Met 
225                 230         

<210> 5
<211> 23
<212> PRT
<213> Malus sp.

<220> 
<223> Conserved region of TIR domain

<400> 5
Asp Val Phe Leu Ser Phe Arg Gly Glu Asp Thr Arg Asn Gly Phe Thr 
1               5                   10                  15      
Ser His Leu His Glu Ala Leu 
            20              

<210> 6
<211> 39
<212> PRT
<213> Malus sp.

<220> 
<223> Conserved region of TIR domain

<400> 6
Ile Lys Glu Lys Leu Phe Arg Ala Ile Glu Glu Ser Arg Ile Ser Ile 
1               5                   10                  15      
Ile Val Phe Ser Lys Met Tyr Ala Asp Ser Ser Trp Cys Leu Asp Glu 
            20                  25                  30          
Leu Val Lys Ile Met Glu Cys 
        35                  

<210> 7
<211> 21
<212> PRT
<213> Malus sp.

<220> 
<223> Conserved region of TIR domain

<400> 7
Lys Leu Gly Gln His Val Leu Pro Ile Phe Tyr His Val Asp Pro Ser 
1               5                   10                  15      
His Val Arg Lys Gln 
            20      

<210> 8
<211> 16
<212> PRT
<213> Malus sp.

<220> 
<223> conserved region of TIR domain

<400> 8
Trp Lys Gly Ala Leu Thr Lys Ala Ala Asp Leu Ser Gly His His Leu 
1               5                   10                  15      



<210> 9
<211> 29
<212> PRT
<213> Malus sp.

<220> 
<223> Conserved motif of TIR domain

<400> 9
Arg Thr Asn Glu Leu His Val Ala Lys His Pro Ile Gly Ile Lys Ser 
1               5                   10                  15      
Arg Ile Gln Gly Ile Ile Ser Asp Leu Ser Ser Gly Gly 
            20                  25                  

<210> 10
<211> 312
<212> PRT
<213> Malus sp.

<220> 
<223> NBS domain of SEQ ID NO:1

<400> 10
Val Gly Ile Trp Gly Met Gly Gly Leu Gly Lys Thr Thr Val Ala Lys 
1               5                   10                  15      
Ala Ile Tyr Asn Gln Ile His Arg Lys Phe Glu Phe Lys Ser Phe Leu 
            20                  25                  30          
Ala Asp Val Ser Asp Ala Thr Ser Lys His Gly Leu Val Tyr Leu Gln 
        35                  40                  45              
Glu Lys Leu Ile Ser Asp Ile Leu Lys Gln Lys Ser Gly Ser Ser Asn 
    50                  55                  60                  
Phe Asp Glu Gly Ile Asn Leu Ile Lys Gln His Leu Gln Arg Arg Arg 
65                  70                  75                  80  
Val Leu Val Ile Ile Asp Asn Ile Asp Asp Leu Lys Gln Leu Asp Ala 
                85                  90                  95      
Ile Ala Val Ser His His Cys Phe Gly Pro Gly Ser Arg Ile Ile Ile 
            100                 105                 110         
Thr Thr Arg Asn Glu His Leu Leu Lys Gln Val Glu Val Asp Lys Thr 
        115                 120                 125             
Tyr Pro Leu Gln Glu Met Lys Lys Lys Glu Ala Leu Glu Leu Phe Ser 
    130                 135                 140                 
Trp His Ala Phe Arg Lys Ser Tyr Pro Asn Glu Glu Tyr Leu Glu Val 
145                 150                 155                 160 
Ser Glu Lys Val Val Ser Tyr Cys Gly Gly Leu Pro Leu Ala Leu Glu 
                165                 170                 175     
Val Leu Gly Ser Phe Leu Phe Lys Arg Pro Ile Ala Glu Trp Lys Ser 
            180                 185                 190         
Gln Leu Lys Lys Leu Glu Arg Thr Pro Asn Gly Glu Ile Ile Lys Pro 
        195                 200                 205             
Leu Lys Ile Ser Phe Glu Gly Leu Asp Asp Thr Glu Lys Ala Ile Phe 
    210                 215                 220                 
Leu Asp Ile Ser Cys Phe Phe Ile Gly Arg Asp Lys Asp Tyr Val Ala 
225                 230                 235                 240 
Lys Val Leu Asp Gly Cys Gly Phe Phe Ala Thr Gly Gly Ile Ser Val 
                245                 250                 255     
Leu Arg Glu Arg Cys Leu Val Thr Val Glu Gly Asn Lys Leu Thr Met 
            260                 265                 270         
His Asp Leu Leu Arg Glu Met Ala Arg Val Ile Ile Ser Glu Lys Ser 
        275                 280                 285             
Leu Asp Cys Pro Gly Lys Trp Ser Arg Leu Trp Asn Arg Gln Glu Val 
    290                 295                 300                 
Thr Asp Val Leu Thr Asn Lys Ser 
305                 310         

<210> 11
<211> 19
<212> PRT
<213> Malus sp.

<220> 
<223> Conserved region of NBS domain

<400> 11
Val Gly Ile Trp Gly Met Gly Gly Leu Gly Lys Thr Thr Val Ala Lys 
1               5                   10                  15      
Ala Ile Tyr 
            

<210> 12
<211> 29
<212> PRT
<213> Malus sp.

<220> 
<223> Conserved region of NBS domain

<400> 12
Lys His Gly Leu Val Tyr Leu Gln Glu Lys Leu Ile Ser Asp Ile Leu 
1               5                   10                  15      
Lys Gln Lys Ser Gly Ser Ser Asn Phe Asp Glu Gly Ile 
            20                  25                  

<210> 13
<211> 15
<212> PRT
<213> Malus sp.

<220> 
<223> Conserved region of NBS domain

<400> 13
His Leu Gln Arg Arg Arg Val Leu Val Ile Ile Asp Asn Ile Asp 
1               5                   10                  15  

<210> 14
<211> 25
<212> PRT
<213> Malus sp.

<220> 
<223> Conserved region of NBS domain

<400> 14
Gln Leu Asp Ala Ile Ala Val Ser His His Cys Phe Gly Pro Gly Ser 
1               5                   10                  15      
Arg Ile Ile Ile Thr Thr Arg Asn Glu 
            20                  25  

<210> 15
<211> 28
<212> PRT
<213> Malus sp.

<220> 
<223> Conserved region of NBS domain

<400> 15
Lys Thr Tyr Pro Leu Gln Glu Met Lys Lys Lys Glu Ala Leu Glu Leu 
1               5                   10                  15      
Phe Ser Trp His Ala Phe Arg Lys Ser Tyr Pro Asn 
            20                  25              

<210> 16
<211> 16
<212> PRT
<213> Malus sp.

<220> 
<223> Conserved region of NBS domain

<400> 16
Lys Val Val Ser Tyr Cys Gly Gly Leu Pro Leu Ala Leu Glu Val Leu 
1               5                   10                  15      



<210> 17
<211> 15
<212> PRT
<213> Malus sp.

<220> 
<223> Conserved region of NBS domain

<400> 17
Thr Glu Lys Ala Ile Phe Leu Asp Ile Ser Cys Phe Phe Ile Gly 
1               5                   10                  15  

<210> 18
<211> 13
<212> PRT
<213> Malus sp.

<220> 
<223> Conserved region of NBS domain

<400> 18
Met His Asp Leu Leu Arg Glu Met Ala Arg Val Ile Ile 
1               5                   10              

<210> 19
<211> 24
<212> PRT
<213> Malus sp.

<220> 
<223> region with LRR motif

<400> 19
Met Lys Lys Leu Ser Leu Leu Ala Leu Leu Phe Arg Lys Glu Thr Lys 
1               5                   10                  15      
Ile Ala Ser Phe Ser Thr Lys Ala 
            20                  

<210> 20
<211> 24
<212> PRT
<213> Malus sp.

<220> 
<223> region with LRR motif

<400> 20
Phe Ala Lys Met Lys Lys Leu Arg Leu Leu Gln Leu Ser Asn Val Glu 
1               5                   10                  15      
Leu Lys Gly Glu Tyr Lys His Leu 
            20                  

<210> 21
<211> 23
<212> PRT
<213> Malus sp.

<220> 
<223> Region with LRR motif

<400> 21
Pro Lys Glu Leu Ile Trp Leu Arg Trp Glu Gly Cys Pro Leu Lys Ser 
1               5                   10                  15      
Leu Pro Asp Asp Phe Phe Asn 
            20              

<210> 22
<211> 23
<212> PRT
<213> Malus sp.

<220> 
<223> Region with LRR motif

<400> 22
Gln Pro Arg Leu Val Val Leu Glu Met Gln Cys Ser Lys Leu Val Gln 
1               5                   10                  15      
Val Trp Lys Gly Phe Lys Ser 
            20              

<210> 23
<211> 23
<212> PRT
<213> Malus sp.

<220> 
<223> Region with LRR motif

<400> 23
Leu His Asn Leu Lys Thr Leu Asp Leu Ser Trp Ser Asp Ser Leu Gln 
1               5                   10                  15      
Lys Ser Pro Asp Phe Ser Gln 
            20              

<210> 24
<211> 24
<212> PRT
<213> Malus sp.

<220> 
<223> Region with LRR motif

<400> 24
Val Pro Asn Leu Glu Glu Leu Ile Leu Glu Ala Cys Ile Asn Leu Ser 
1               5                   10                  15      
Glu Ile His Pro Ser Ile Gly His 
            20                  

<210> 25
<211> 24
<212> PRT
<213> Malus sp.

<220> 
<223> Region with LRR motif

<400> 25
Leu Lys Arg Leu Ser Leu Val Asn Leu Lys Trp Cys Asn Lys Leu Ile 
1               5                   10                  15      
Ser Leu Pro Arg Asp Phe Tyr Lys 
            20                  

<210> 26
<211> 23
<212> PRT
<213> Malus sp.

<220> 
<223> Region with LRR motif

<400> 26
Leu Lys Ser Val Glu Leu Leu Leu Asn Asn Ser Tyr Gln Phe Arg Glu 
1               5                   10                  15      
Val His Glu Asp Ile Gly Glu 
            20              

<210> 27
<211> 23
<212> PRT
<213> Malus sp.

<220> 
<223> Region with LRR motif

<400> 27
Met Ile Ser Leu Arg Thr Leu Glu Ala Arg Gly Thr Ala Ile Arg Glu 
1               5                   10                  15      
Val Pro Pro Ser Ile Val Gly 
            20              

<210> 28
<211> 41
<212> PRT
<213> Malus sp.

<220> 
<223> Region with LRR motif

<400> 28
Leu Lys Asn Leu Thr Arg Leu Ser Leu Glu Gly Thr Met Arg Gly Ile 
1               5                   10                  15      
Gln Leu Pro His Ser Leu Arg Glu Ile Asp Leu Thr Tyr Gly Ala Leu 
            20                  25                  30          
Asp Asp Ala Ile Lys Asp Leu Gly Ser 
        35                  40      

<210> 29
<211> 22
<212> PRT
<213> Malus sp.

<220> 
<223> Region with LRR motif

<400> 29
Leu Ile Tyr Leu Gln His Leu His Leu Gln Gly Asn Asn Phe His Ser 
1               5                   10                  15      
Leu Pro Asn Leu Ser Gly 
            20          

<210> 30
<211> 21
<212> PRT
<213> Malus sp.

<220> 
<223> Region with LRR motif

<400> 30
Leu Leu Lys Leu Glu Thr Leu Trp Leu Asn Gly Ser Glu Tyr Leu Arg 
1               5                   10                  15      
Thr Ile Pro Asp Leu 
            20      

<210> 31
<211> 23
<212> PRT
<213> Malus sp.

<220> 
<223> Region with LRR motif

<400> 31
Pro Thr Asn Leu Lys Val Leu Phe Ala Asp Ala Cys Pro Ala Leu Glu 
1               5                   10                  15      
Thr Met Pro Asp Phe Ser Glu 
            20              

<210> 32
<211> 24
<212> PRT
<213> Malus sp.

<220> 
<223> Region with LRR motif

<400> 32
Met Ser Asn Met Arg Thr Leu Asp Val Ser His Ser Ala Lys Leu Thr 
1               5                   10                  15      
Gly Val Pro Gly Leu Asp Lys Ser 
            20                  

<210> 33
<211> 23
<212> PRT
<213> Malus sp.

<220> 
<223> Region with LRR motif

<400> 33
Leu Asn Ser Met Val Trp Leu Asp Met His Arg Cys Pro Asn Leu Thr 
1               5                   10                  15      
Ala Asp Phe Arg Lys Asn Ile 
            20              

<210> 34
<211> 28
<212> PRT
<213> Malus sp.

<220> 
<223> Connecting region

<400> 34
Gly Thr Gly Glu Ile Glu Gly Leu Ala Leu Tyr Phe Pro Lys Glu Thr 
1               5                   10                  15      
Lys Ile Ala Ser Phe Ser Thr Lys Ala Phe Ala Ile 
            20                  25              

<210> 35
<211> 119
<212> PRT
<213> Malus sp.

<220> 
<223> C-terminal region

<400> 35
Leu Gln Gly Trp Thr Ser Cys Gly Phe Gly Gly Ile Ala Leu His Gly 
1               5                   10                  15      
Asn Tyr Val Pro Asp Trp Phe Glu Phe Ile Asn Glu Gly Thr Lys Arg 
            20                  25                  30          
Thr Lys Leu Arg Ala Tyr Lys Thr Lys Ala Ser Tyr Thr Ile Asp Glu 
        35                  40                  45              
Asn Tyr Glu Asn Asp His Leu Trp Gln Gly Gln Phe Ser Asn Asn Glu 
    50                  55                  60                  
Leu Asn Leu Gln Gly Gly Asp Lys Val Asp Ile Val Phe Glu Asn Leu 
65                  70                  75                  80  
Asp Glu Asp Asp Ser Val Lys Met Met Arg Thr Gly Val Asn Leu Val 
                85                  90                  95      
Trp Asp Lys Leu Met Lys Glu Asn Met His Asp Leu Gly Asp Thr Arg 
            100                 105                 110         
Gly Arg Ile Ser Phe Gly Ile 
        115                 

<210> 36
<211> 9780
<212> DNA
<213> Malus sp.

<220> 
<221> source
<222> 1..9780
<223> /mol_type="unassigned DNA"
      /note="Vr2-A gene "
      /organism="Malus sp."

<400> 36
ttgccggaga tgagagagag gatagcaaga agagagatga gcggcgggag tgtgggagag       60

gccgaacaat tttagagttt tcagtttatt attattattt tttaatgtga tatatataaa      120

ataaactggt aaatagatat ctgttataat taggagcaat aatcataatt atccatttaa      180

attttacgga taaataattg tatccataac tttttattta tttaaatgat tatcaataat      240

cataatcgtg aattttaaat gaacggggta atagtacccg ggggaggagg gggtattttg      300

ctcattccaa atctcaactc gccacttcct ggaaagcaaa gagaaagcca attggtggaa      360

tattgaattg ggatgtaatc atgtgagtgc agtagacgta ggcgttcttg tatgtatttg      420

agtgcttctg gcattgctcc atccacattt tccttgcctt gcccgtcaca gggcaaaact      480

tatcactcta accctacttt ctctaccttc aatgtttcta tacatgaaaa tcgatctggt      540

ccgttctata cttgacagga aaaataattc tatacaaatt tcaatgcact tgacactcac      600

ttcaggatca atggcattga ttggataagg tgagcaaatt cttatcaata ccttccctca      660

ttgtttagtt tttttataaa acatcataac tccaaaggaa gccataaagc atcataactc      720

caaaccaaaa accagtttta tttataatat atttagactt tggtggcttg ttggtatagt      780

gttttttaca gtaattagga ctaatataaa ttaaaagctc atctggtaac gtttcactac      840

cagtttaaaa atcaaaacaa caaaaataga actttacatg tttaattaaa atctcaaaac      900

gacaaagttg catgactttg actccgcgct agtttatatg tatgtgaaga ttattatgct      960

aaaatggatt ctcagtgtgc aactctccgt ttctggaact cggtcatttc tcaagtttta     1020

gatgtgaagg ctaattatta agactttaga cttgggtatt tatttcggta ttatctttgt     1080

agcttaccac acacacataa caaatgcaaa tattgtaaag attcatacag actgatcaat     1140

gacccatcat taatcacacc aattatgaca tcccacatcg cccaggggag tgatccttaa     1200

atgtatattc tcattcctac ctagcacgag gcattttggg agctcactgg cttcgggttc     1260

cgtagaaact cggaagttaa gcaagaagga ggtcagatca ctcccaggat gggtgaccca     1320

ctgggaagtt gctcatgagt tcccaaaaac aaaaccgtga gggaatggta agcccaaagc     1380

ggacaatatc gtgttacggt ggttgagcgg gcctgtgatg tgacaaattg gtatcagagc     1440

caatccctgg ccggaagtgt gccgacgagg acgtcgggcc cctaatgggg gtggattgtg     1500

acatcccaca tcgcccagga gagtgatcct taaatgtata ttctcatccc tacctagcat     1560

gatgcttttt gggagctcac tggcttcgta ttccgtagga actccgaagt taagcgagaa     1620

ggatgccaga gcactcccag gatgggtgat ccactgggaa gttgctcatg agttcccaaa     1680

aacaaaaccg tgagggaatg gtaagcccaa aacggacaat atcgtgctac ggtggttgag     1740

caggcccggg atgtgatgga cccgggccgg gatgtgacac caatactttc tctcaccctt     1800

aatcttacca catgcacaac atgtcatacg tgaaagtttt atcacaaaat actttgatat     1860

aattaaaagt ggaaaccaca caatataagt tatctttaat tttgtgaaat tttatatgag     1920

atttttgtac acttcaacat gtatagggat ggacttcttg tggatatggt ggcatttgtc     1980

tcatggtatt tgtgatattc ccgagtagtt tgagtttgct tatgagggaa atgtaactga     2040

ctttattata cctgaaagtg atgtttaaag ggttggttgt gcatttactc gtcaagtgaa     2100

caacttgaca gtcctcatgt ggttattgtt ataaattcta ccaagcatac cacttggcac     2160

gccttgatag catttacctc agtactacca aaatctcagg aaagcgaaag cgattatctt     2220

tggcaaggag agatattgta gaaaaaaaaa aaacagtgtg tgacaaaaat taatgcataa     2280

gaagcaaaat taaaacagaa tgttactaac attggctggg aataaatgta acatgaggta     2340

gatcttaatt aatgtaacgg gaacatcaat gatataccat gtgtttttag gtaagtgatg     2400

agaaatttta ttttttaagt tattaaattt ttaaaacata ttctactatt tgtataataa     2460

tacttgatgt atcacatcgt gtgtcagtca cactgaaaaa tctctctttc acgttagcct     2520

tttccttgtg ttcagatatt cttgaaaagc aaacacgaac cttttccttc acgtgaataa     2580

agcatctttc agaattcaga gttcctttcc tattacatgt cggtagtatg tccttttgtg     2640

ttcttttctt tgatcttttc ctctctcttt ccttacacct tcccgccggg tagtgagtcg     2700

tttctcatgt ccatacgcca acattattat attataagct tttgcttttg tttactgaag     2760

gatcttaact tgtgtttagg tatcatcctt cggcaacaca aacacaaccc ttgccatttt     2820

tcagtctctg atctgaacca ctgcagtgcc ataacggtgg ataccgccat gacaggccat     2880

gaagcctcct cttcttcctc ctccaagtca aaactttgga attacgacgt gttcttgagc     2940

ttcagaggcg aagacacgcg caagggcttc acaggccatc tccacgcggc attgaaagac     3000

aggggatacc aggcttatat ggatgaggac gatctaaaca gaggggaaga aataaaagag     3060

gaactgttcc gggcaatcga agggtcgagg atctctatca ttgtcttctc aaaaggatat     3120

gcggattcga gttggtgtct tgacgagcta gtgaagataa tggagtgcag atccaaactg     3180

aggcgacatg ttttgccaat attctatcat gttgatcctt cacatgtcag gaagcaggac     3240

ggagatttag ccaaagcatt tcagaagcac aaaaagggca tcagtaaact aaaagatgcc     3300

aagaaacgtg aagcgaaacg agaaagggta aagcagtgga gaaatgctct cacggaagcc     3360

gcaaatttgt ccggccacca tcttcaaatc actgaaaatg ggtaatcatt cacctgcttt     3420

tcaagatttc aaacatttta gaggacaatt gttagaagag ggagtatcac acacaaatga     3480

aaaaatatat acgaatttat aaaatcaaga aatagatctg aaatttagac atctttaagt     3540

tgtattactc ttattaactt gctagctaat aatttaacca aacaacttat aatttaactt     3600

gctagctacc ttctttatgg aaatttttta gttgtggcgg gaacattgat gatacaccac     3660

gtgttttcag gtaagtagtg agaaatttta ttttttaagt tattaacttt ttaacacaca     3720

tatctcacga tttatatagc tacacatgat ataccacctt atatgacgat cacactgaaa     3780

aatctctcat ttatttgtct ttactctttt ttcacttgta cgggttaccg taccaaaacc     3840

cttataccaa ttatcgtacc aaactttcaa tttggtaaaa tctattatca ttaccatacc     3900

aaactttcgg tatatcaaag tttggtattg ccaaaagttc ggttgacatg gtatggcaat     3960

ggtaattgct attttgtttt gggacaaaat ctgtttttgt ttttttaacc caattcaagg     4020

gcaaaacttt ttttttgtac ctttatctca tacattatag attaaattca tcattcacaa     4080

ttcacacata taataattca aatgatgcat caagattcat catgaaaatt aagtttacaa     4140

tccaaataga agttacgaat aaaaacaaat agaagttaac aatccaaata gaaattaaag     4200

tttcaaacca aatgaaaatt ggaagtaaac ttcaaaaatg agaattcatt gatcaggtat     4260

tcaaacttga gatgtcaaag tttttggata aggcattgaa cttatagaag attgagtttg     4320

tgtcaagcct aaattacaaa caaagaaaac atattaatta gtagcaagaa taattaaagt     4380

tgaaaaccat ttaataacaa atttactgaa aaaattaaag catatctttc ttatttcctc     4440

ttcttctatt tccttgtaaa attgaagcat atctttcgtt gattccttgt agaagtttac     4500

ttcatctgcc ctaagccaat caatagtacg cactagtgcc tccattattt taggagttaa     4560

ggatacccta aaagggtcca caacctcatc cttaggctaa atgcattttc actagcaaca     4620

atagaagtga gggttacaaa gatattttgg ctatttgtga aagaattagg aactcttctt     4680

gtttgatttc cacaatttca agagatcaaa gttaacaaca acaatgctaa tataagtagg     4740

gttttatttt caaattattg gaatattata aatatgtgtt atataattat ctattatata     4800

atttataaat gatatattat attgtatttt cggtatgata cggtaatacc gtggtaatgg     4860

tattcattac caataccgta ccatgaaatt ttggtacgat acaataccgt acccttaccg     4920

attggtacaa aaaatttggc acaaaatcgg tatggtacgg ttggcaattc ggttggcacg     4980

gtaatttggc aaaaaaatcc accctctttc ccactccttt catgccatgt ggaatcaact     5040

tatacttata tgtatttaat gtgtatagaa atttatttct ctttccaaat acgcccttaa     5100

ttaatgtttc agatttttgt tttcttgagt gcaaatgttt catattttaa ccaaactatt     5160

attacttatc ttttttatta aaaaatttta agcatttctt atttgctttg ccatcttctg     5220

agaaatttta atctccacaa aaacaatata ggaggtgact gcctactatt tataaatatt     5280

caaacattat aatttatatc caacagaaaa aaaaattata atttataagc ctccggcttt     5340

tatataatac aagagaaaga tgcattgaaa taccaatttt gtgaaattca tgtaaaaaaa     5400

attgcgcaaa ttgttataca aataatgcaa ttaaacagag ttaaacaatt caaaaagaaa     5460

aacaattaaa aaaatcttat attagcattt tattttccac tttgaattcc catttgtctt     5520

tttcttttct tgtaccaatt ctcggttaac tttgtcctcc tgtactgttt ttagtgggaa     5580

aaaatttcca ggaacagaat aatgcatttg aaaaaaagaa cggcaaaaga aaataaaatt     5640

gaaagacaac tccacccaga gcttcagaac ataatttatt taataaaaaa atccataaca     5700

aattagaaat gtttaaaaag ctatatttta ataaaaaaaa gtgaagcaat aattgtttgg     5760

ttaaactctg gaacattaaa ttaggggcat attaagaaag aaaaaaaata aaattctcta     5820

ccaattaaat acataaatgc atatgtaagt tgattccaca gtaagtaaat aaagaaagag     5880

aattgtttat gttctgatat ctcctacata gcctttcatt gtgtcccact aatgcttaag     5940

aattcaattt tcaggagcga agcggacttc attaggatta ttgttgatga gaatatttgt     6000

gaatggctca ccagcacaaa cgaattacat gtggccaatt acccagttgg aatcgattct     6060

cgcattcaag atatcatcac ttatctttca agtggtggat caaatgatgt tcgcatggtt     6120

ggaatttggg ggatgggtgg agtgggtaaa acaacagttg ccaaagccat ttataaccaa     6180

attcatccta tgttccaatt caaaagtttc cttgccgacg ttcgtgatgc tacaagtaaa     6240

catggtctgg ttgatttgca aaacaaactt atttctgaca tcttgaaaaa gaagcctgaa     6300

ataagatgtg ttgatgaagg tatcgttatg ataaaacaac aatttcgaca taaaagggta     6360

cttgtcatca tggacaacat agacgaagta gaacaattgg atgcaatagt tggaaatcat     6420

gattggtttg gtccagggag tagaattatc ctaacaacaa gagatgaaca tttactaaag     6480

cgagggaaag tgcacaacat atatccggct cagaaattca atgaaggaga agctctggag     6540

ctctttagtt ggcatgcctt tggaaatggt tgtccaaaca aaggatatca tgaactctca     6600

aaaaaagttg tttcttattg tggaggtttg ccactagccc ttaaagtttt aggttcattt     6660

ttgtttgaaa gaaccatggc agagtggaaa agtcaattgg agaaattgga aagaactccc     6720

gatggaaaaa taataaaacc actaagaata agctttgatg ggctagatga taaacaaaag     6780

gctatattcc ttgacatatc ttgtttcttt attggaatgg acaaggacaa tgtcgcaaaa     6840

gcattagatg tatgtggatt ttctgcgaca atagaaatta gtattcttcg tgaacgatgc     6900

cttgtaactg ttgaagataa gaagttgaat gtgcatgatt tgcttcgaga aatggccaaa     6960

gtaatcattt ctgaaaaatc ccctagtcac cctgaaaaat ggagtaggtt gtggaaccat     7020

caagaggtcg tagatgtctt gagaaataaa tctgtaagta cattcccaat aaaattttgc     7080

attaatgcat cctacatata acccacgtct atctgttatg cactaaacaa gatttatgtg     7140

taacactaaa tatattcacc atagttgatt tagcctaatg aataataata tgcaaataat     7200

ctgtttctta cacatgaata taaccttttg ttaacaggga actgaagaag ttgaaggact     7260

tgctctacat aaaccttttt ctcatgacaa ttctagtttc aatacagaag catttgccaa     7320

tatgaagaaa ctgagattgc tcctgctata caaggtagag cttaatggag aatacaaaca     7380

tcttcccaat gagttaatgt ggttgcgttg ggaagaatgc cttttaaagt ccataccaga     7440

tgactttttc aatcagccaa gactagttgt tttagagatg cagcggagct atctggtaca     7500

agtttgggaa ggttccaagg tactcgatta cacatgatga tgttctattt ctatttgttt     7560

ttggatttcc ttctttttat gagatgttcc ttttgaatat taatttcaaa ttttctttgg     7620

ttttgtgcaa cagtcgcttc agaatttgaa aaatcattga tctcactcgg tcctattcct     7680

taataaaatc accagacttt tcacaagtcc caaatcttga agagttgata ttggaaggtt     7740

gtgagagttt gtatgagatt gattcctcca ttggtcatct taaaagactt tctttggtga     7800

accttagagg atgcagaatg cttacttctc ttccaaggga tttctataag tccaaatctg     7860

ttgagactct ttgtcttaat gactgttcag aattcagaga agtgcatgag gatttagggg     7920

agatgatatc attgagaata cttgaagcag atttcacagc cataagacaa ataccaactt     7980

ccatagtaag attgaagaat ctcactcgtt tatccctaat aaatcctatt tcccgaagag     8040

gttcatccct aataggtgtg gaaggtattc atttgcccaa ttcattaaga gaattaagtc     8100

tctcggtgtg caaattagat gatgatgcaa ttaagaatct tgggagtcta atttctttac     8160

aatatttgga tcttggatgg aataaatttc atacccttcc tagcctcaat ggtctttcaa     8220

agcttgaaac tttgcagtta agtggatgca tgtatcttca tacaatccct gatttaccaa     8280

caaatttgaa ggttctgcat gtcgatgaat gccctgcgtt ggaaacaatg cccaattttt     8340

cggaaatgtc aaatataaga caactccatg taagtcattc acccaaactc actgaggttc     8400

caagcttgga taagtcatta aactccatga tatggattga tatgcatgag tgcaccaatc     8460

tcacagctga ttttaggaag aacatcctac aggtatatat atctctctct ctcccattgc     8520

cttcatatcg tgcacatgca cacacaaacg cacatgtgca tgtatatata tttatgacac     8580

ttgcattgta tgtgtaggga tggacttctt gcggatttgg tggcattgcc ctccatggga     8640

attatgttcc tgattggttt gagtttgtca acgagggcgc taaagttagt tttgatattc     8700

ccccgactca tgatcgtact tttgaagggc taactctgtt cttcttgtac cgcccattca     8760

aagcgacaat tttaaatcct cttgaaatca ctgttataaa taataccatg tgtacagtgt     8820

tgcgggccta cgtaaacaac agaggttctc tgattaatac atttgtagat ggtgatgaat     8880

atctttggca agtacaactc tcgaacaatg agctcaattt gcaaggtggg gataaagttg     8940

atatactttt taaagacgag tactatgcgc ggaataatgc tcttaaaatg atgagaatag     9000

gggttaatct agtatgggac aaacctatga agaaaaatat gcatgatttg gacagagcta     9060

gattttcttg tcactggaga tccagcttac ttcttggatg agggaggacc aagccatgat     9120

gcatctgata aactcgtttg tgcagaatga aggtggtgac agcatcacag tcaattcgtc     9180

aaacgcctcg tcatttttcg ctttcctagt tcgataatgg aggcaagtcc atatttcata     9240

ccactttttc agattcctac gattttttga ataagtagtt ttgagttttg aagatatatt     9300

gcatcaagaa acatttcaac attacaacaa tcaataatca atagaccacc caaatatttg     9360

acaaatacta ctcaaatact tgccctgttt ccgccacata ttcaaggaat ttactgttag     9420

actatgtttg gacgacggaa ataaacttga aattgagata aaaatcagaa tttataaatt     9480

ggcatgcatc aattcccttg tttggattca taaacataga aatttagaat tttcttgtgg     9540

aataaaaaaa cttggaattt ggaaccttca atttccaagt ttaaattcca tataaataag     9600

tgtcatttcc caatatctat gattgagagt ttaaaaatat caaattacgt attcaattct     9660

attgtttttt taggttaatc aaacaagaaa attcacaaat tttaaaaaat aaaatactat     9720

aattttaaaa ttcataagta atcttaaatt tcttcatcca cacatagtgt taaggttaga     9780


<210> 37
<211> 8514
<212> DNA
<213> Malus sp.

<220> 
<221> source
<222> 1..8514
<223> /mol_type="unassigned DNA"
      /note="Vr2-B gene"
      /organism="Malus sp."

<400> 37
attcctccag cccaccaaac acagtactaa tatatacata tatatgcagt tatatatttg       60

tatatgcacc ttctttagtt tctttgtcaa ttatataatc tctctgttaa tattaaaaaa      120

catttgattt agtaacttga tctcaactat tgtaatgcag ttcaagattt ccacgttaat      180

ttagtttaat attaaataaa tggtttgcac agctaattgc atgtagttct ctttatctct      240

attctcctca tcaatgcgaa ggaatgtaaa gatttttttt ctcccatttt cattatgccc      300

aatttcaaat tgaaatatat ttatttatct ttcttttgaa taggacttcg acctactaat      360

tttttcctga aattatagcc tcttaatcga tagtaaaaaa taaatggtga atataagaac      420

aaactcattt gtgctaattt tttaatgctt aataagattt acaaaaccct gtattttaaa      480

aaatagttat tttttagttt tgtggactat cctctcttac cgattgtcaa caaccttcca      540

tgggaccttc gattcccaag gagttcaata aattatagac tacaatgcaa gtaaaaaatt      600

aatctaaaag ctttaaaaat tttgaacatt tgataatttg ctttccaaaa ttctgattat      660

ggctgtactt ttttcaatcc ttacattctt tattacgttc ttaaattatt ttagtacaat      720

gtgttaaata tttctgatta ctaaatcaaa tcatcaccat tcaatttgac aggaaaaaga      780

atcctaacat tattcttatg attcacatat gtgtgattct caatgcactt gacagaaaaa      840

agatttctat acaaatttca atacacttga cactctcttc agggtcattg gcattgattg      900

gataaggtga gcaatttctt atcaatgctt tctctcattg tttagtttat tttttttata      960

aaacatcata actccaaacg aagccataaa gcatcataac tccaaaccaa aaaccagttt     1020

tatttataat ataacattta gactttggtg gcttgttggt atagtgtttt tacagtaatt     1080

aggactaata taaataaaaa gctcatctgg taacgtttta ctaccagttt aaaaatcaaa     1140

acaacaaaaa tagaacttta catgtttaat taaaatctca aaaagacaaa gttgcatgac     1200

tttgactctg cgctagttta tatgtacgtg aagattatta tactaaaatg gattgtcttt     1260

gcaacttcaa ttttgtgcaa ctctccgttc ccgggattcg gtcatatctc aagtttttga     1320

cgtgaaggct atattattaa atttagactt gggtatttat ttcggtatta tctttggtag     1380

tttaccacac gcacataaca aatgcaaata ttgtcaaagg ttcatacata ctgatcaacg     1440

acccatcatt aatcacacca atattttctc tcagcttgaa tcttaccacg tgcacaacat     1500

atcatatgtg aaagttttat cataaaatac tttggtataa ttagaagtgg aaaccgcaca     1560

atataagtta tctttaattt tgtcaaattt tatgtgagat tcttgtacac ttcaacatgt     1620

attgggatgg actccttgtg gaaatggtgg tatttatctc atggtattta tgatattccc     1680

gagtggtttg agttcgctta tgagggaaat gtagctgact ttgttatacc tgaaagtgat     1740

ggttgtaatt ttaaagagtt ggttgtctga cgcatttcct cgtcaagtga acaacttgaa     1800

ggtcctcatg aggttattgt tataaattcg accaagcata ctactttgca caccttgata     1860

acatttacct cagtgctacc aaaatctcat gaacgcgaaa ccgattatct ttggcaagga     1920

gagatactgc agaataaaaa catagtgcga aaaaaattaa tgtatatgtt cttgaagaaa     1980

attaatgtat aaaaagcaaa attaaaacag aatgttacta acattggttg ggaataaatt     2040

gtaacatgag gtagatctta attaaacagg agccttttcc ttgtgttcag gtattcttga     2100

agaaaagcaa acatgagcct tttccttcac gtgaataaag catatttcac tttcagagtt     2160

ccttccttcc ctgctttcca ccgtcctatt acgtttcggt agtctgtcct ttcgtgtttc     2220

tttatttccc cttttcctct ctctttcttt gcaccttcct gcccggtagt gtgtcgtttc     2280

tcaagtccat acgccaacat tattatatta taaacctttt gcttttgttt actgaaggat     2340

cttgacttgt gttaaggtat catccttcgg cgacacaacc acaaccattg ccattttttc     2400

agtctctgat ctgaaccatt gcagtgccat aacggtggat accgccatga cagcccacga     2460

agcctcctct tcgtcctcct ccaagtcaaa actttggagt tacgacgtgt tcttaagctt     2520

cagaggcgaa gacacgcgca atggcttcac tagccacctc cacgaggcat taaaaaacag     2580

aggataccat gtctttattg atgaggacgg tctaaaaaga ggggaagaaa taaaagagaa     2640

actgtttcgt gcaatcgaag agtcgaggat ctctatcatt gtcttctcaa ggaggtatgc     2700

ggattcgagt tggtgtcttg acgagctggt gaagatcatg gagtgcagag gcaaactggg     2760

gcatgttttg ccaatattct atcacgttga tccttcgcat gtcaggaagc aggacggaga     2820

tttagctgaa gcatttcaga aacacgaaac ggacatctgt gaagaaaaag atgacgagaa     2880

acgtaaagct aaacaagaaa gggtaaagca gtggagagag gctctcacag aagctgcaaa     2940

tttgtctggc caccaccttc aaagcgctaa taataggtaa ttattcacct acttgtcaag     3000

atttaagttg taatactcta attaacatac ttaattaata caccttaatc tctcacgctg     3060

atccttcaca tgtcaggaag aggcggagag agggtcatac agaagataca aatttgtctg     3120

accaccaaac aactggcaac gggtaatcat ttacctgctt atttcaagat ttgaaacatt     3180

ttagtgaatg acttgatctc tcaattaatt aacattttac ataatttttt tttttttttt     3240

gtagaaaagc tcgacggatc taaactttag tttacatgct taatgaatac accttaatct     3300

ctcatataaa acctaaaccg taattgtagt ttaattcaca cacctaacta ctttctttct     3360

tttattcaag tttcaagtta tcgtcacaaa atcacatgct agctgctagt tagtgtatta     3420

tatatatata tatatatata tatatatgaa gaaaagaaag aaaattgtca tgtactgata     3480

tctcctacag agcctcattg agtcccatta atgcttacga attcaatttt caggtgcgaa     3540

gcagagttca ttaaaaaaat tgttgatgag aatatttggg aatggctccc cagaacaaac     3600

gaattacatg tggccaggca cccaattgga atcaaatctc gcattcaagg tattatcagt     3660

gatctttcaa gtggtggatc aaatgatgtt ctcatggttg gaatttgggg gatgggtgga     3720

ttgggtaaaa caacagctgc caaagccatt tataaccaaa ttcatcatat gtttgaattc     3780

aaaagtttcc ttgccgacgt tagcgacact tcaagtaaac atggtctggt ttatttgcaa     3840

gaaacactta tttctgacat cttgaaacag aagtctcaaa taagaaatgt tgacttaggt     3900

atcaatatga tacaacaagt agttaaacat agaagggtac ttatcatcat tgacaatata     3960

gatgaccgga aacaactgga agcaatagcc caaagtcacg attggtttgg tccaggaagt     4020

agaattatca tgacgacacg gaatgaacat ttactaaaga aagtggaagt ggacaagaca     4080

tatccgcttc gggaaatgaa aaaggaagaa gctctggagc tctttagttg gcatgccttt     4140

caaaaaagtt gccctaatga agaatatctt gaagtctcaa aaaaggttgt ttcttattgt     4200

ggaggtttgc cactagccct tgaagtttta ggttctcttt tgcttaaaag acccattata     4260

gagtggaaaa gacaattgga gaaattagaa agaattcctg aaggagaaat aataaaacca     4320

ctaagaataa gctttgaagg gctagatgat acagagaagg ctacattcct tgacatatct     4380

tgtttcttta ttggaaagga aaaggactat gttgccaaaa tattagacgg atgtggattt     4440

tatgcaacat taggaatcag tatccttcgc gaacgatgtc ttgtaactgt tgaatacaat     4500

cgtttgaaaa tgcatgattt gattcgagaa atggccagag taatcatttc tgaaaaatct     4560

cttgatcgcc ctggaaaatg gagtaggctg tggaaccgtc aagaggtcac cgatgtattg     4620

acaaataaat ctgtaagttc attcccacta aattttggat ttatgcgtca tacaagaaaa     4680

gcatatatgt aacccgtgca agtcaagtat acataaacaa cattcatgtg taaatatatt     4740

taccgtacgt gattttgtgt aatgaataat aataataaat gtaaacctat gcaaatatac     4800

cgtttcttac ctctataact tttttttttt ttttgttaac agggaactgg aaaaattgaa     4860

ggacttgctc tagagtgccc tcctgatcct ttgttttcat tctttggttt cagtacaaaa     4920

gctgctagtt tcagtacaga agcatttgcc aatatgaaga aactgagatt gcttgagctc     4980

aactacgtag agctcaaagg agaatacaaa catcttccca aagagttaat atggttgtgt     5040

tgggaaggat tccctttaca gtccatacca gatgactttt ttaatcaaga taaactagtt     5100

gttttagaga tgcacgggag cgatctggta caagtttggg agggttccaa ggtacaatga     5160

attacacctg atgatgttat gtttctatat gttttttttt tttcataaca tcttcatttc     5220

ggatattaat ttcaatcttc ttttgatttt ctgcaacagt cgcttcgtaa cttgaaaacc     5280

cttgatctct gttgttcctc gtccttacag aaaccaccgg acttttcaca agtcccaaat     5340

cttgaagagc tgatattgga agggtgttct agtttgttcg agattcaccc ctctattggt     5400

tatcttaaaa gactttcttt ggtgaacctt aatggctgtt acagtctcag ttctcttcca     5460

agggatttct ataggtcgaa atctgttgag actcttcttc ttaatagatg tacaaaattc     5520

agagaactgc atgaggatgt aggggagatg atatcactga gaacacttga agcaaaggat     5580

acagccataa gagaagtacc acattccatt ggtcatctta aaagactttc tttggtgaac     5640

cttacccgat gttgggaact caggtctctt ccaagggatt tctataagtc gaaatctgtt     5700

gagactcttc ttcttaatag atgtacgaaa ttcatagaac tgcatgagga tataggggaa     5760

atgatatcac tgagaacact tgaagcaatg tttacagcca taagagaagt accaccttcc     5820

atagtaagat tgaagaatct cactcgttta tccctggact gcatcagcgt agagctcaag     5880

ggagaataca aatatctgtg ttggaaacga tgccctttaa agtccatacc aggtgacttt     5940

tttaatcaag atagactagt tgttttagag atgccgcaaa gcaaactggt acaagtttgg     6000

gagggttcca aggtacaatg aattacacct gatgatgttc tgtttctatt tgttttttgg     6060

attttttttt tttttataac atcttccttt cggatattaa tttcaatttt cttttgattt     6120

tctgcaacag tcgctacata acttgaaaac ccttgatctc agctattcct attccttaca     6180

gaaatcaccg gacttttcac aagtcccaaa tcttgaagag ttgatattgg aatggtgttc     6240

tagtttgtcc gagattcacc cctccattgg tcatcttaaa agactttctt tggtgaacct     6300

taatggctgt tacagtctca gttctcttcc aagggatttc tataagtcga aatctgttga     6360

gactcttctt cttaatagat gtacgaaatt tagagaactg cataaggata taggggagat     6420

gatatcactg agaacacttg aagcagagga tacagccata agagaagtac caccttccat     6480

agtaggattg aagaatctca ctcgtttatc aggtgtggga agtattaaac ttgaccgcat     6540

cagcgtaaag catacagcca aagagttaat acggttgcgt tggaaaggat gccctttaaa     6600

gtccatacca ggtgactttt ttaatcaaga tagactagtt gttttagaga tgccgcaaag     6660

caaactggta caagtttggg agggttccaa ggtacaatga attacacctg atgatgttct     6720

gtttctattt gttttttgga tttttttttt tttttataac atcttccttt cggatattaa     6780

tttcaatttt cttttgattt tctgcaacag tcgctacata acttgaaaac ccttgatctc     6840

agcggttcct ggtccttaca gaaatcacta gacttttcac aagtcccaaa tcttgaagag     6900

ttgatattgg aagggtgtga gagtttgttc gagattcacc cctcaattgg tcatcttaaa     6960

agactttctt tggtgaacct tggagaatgc gataagctta tttctcttcc aagggatttc     7020

tttaagtcga aatctgttga gactcttctt cttaattact gttcagaatt cattgaactg     7080

catgaggata taggggagat gaaatcactg agaacacttg aagcaatgtt tacagccata     7140

agagaagtac caccttccat tggtcatctt aaaagacttt ctttggtgaa cctcacaggc     7200

tgcgacaatc ttatttctct tccaagggat ttctataaat tgaaatctat tgagactctt     7260

cttcttaatg gatgtttaga attcatagaa ctgcatgagg atatatggga gatgatatca     7320

ctgagaacac ttgaagcaaa ggatacagcc ataaaagaag taccacattc catagtaaga     7380

ttgcagaatc tcactcgttt atacctggac aagtactgcc tgagcataga gctcaaagga     7440

gaatacaaat atctgtgttg ggacctatgc cctttaaagt tcataccaga tgactcgttt     7500

atcttggact tttttaatca agatcaacta gttcgtttaa agatgcatgg gagccaactg     7560

gtacaagttt gggagggttc taaggtacaa tgaattacac ctgatgatgt tctgtttcta     7620

tttgtttttt ggattttttc tcatttttgt ttataacatc ttgtgttata aaggaaagct     7680

tatttattga tatccccgat aagctacaaa tatgtacata tacatgagtc aaaataaaca     7740

aacaagatgg agccttcaca aaggttgctt aggagaagtc tcagcagtcg gtagagcccc     7800

agaaagagaa ggcatcggag ggggatcatt cggagcctca gtactggaca gaaccctaga     7860

aggaggaggc atcagaggtt gatcatttgg agcttcatta cgcggtacag ccccagaaga     7920

cgaaggcaat aaatgccttt ggaacaaacc cacaaatctc tgatgatcaa gtaaaacctg     7980

accatcagtt tccttcatct ggtcaagctt cctcttcatg tttgtagcat agtcatgtgc     8040

gagccggtgc aactgtttat tctcgtgctt gagccctcta atctcctgtt tgagactcat     8100

cacttcggcc gccaatgatt caacttggcg ggttcgagca aataggcgtt gggccatatt     8160

agacacagaa cctgcacact gaacactgag agccagcgaa tccttaacag ccaactcatc     8220

agatcgtttg gaaagtagtc tgttatcttt gggagtgaga aggttcctgg ccaccaccgc     8280

agcggtcata tcattcttca tcacggaatc cccaacggta agaggaccag taggggagac     8340

gaaggatggg cgccatatgt tgtctggaga aggcggggct gcctcttcaa caaggttcaa     8400

gtcaaaacga cggtcggagg ggccagacat tttcaaaggt gttgaagaga gaagaggtcg     8460

gacaaatcaa gatcttagaa gtgcaagatt ggagcttcta ctggtggaga ttca           8514


<210> 38
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="primer"
      /organism="Artificial Sequence"

<400> 38
ccttgcgcgc cttgccggag atgagagaga                                     30


<210> 39
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="primer"
      /organism="Artificial Sequence"

<400> 39
ccttacgcgt ctaaccttaa cactatgtgt                                     30


<210> 40
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..29
<223> /mol_type="unassigned DNA"
      /note="primer"
      /organism="Artificial Sequence"

<400> 40
ccttgcgcgc cattcctcca gcccaccaa                                      29


<210> 41
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..28
<223> /mol_type="unassigned DNA"
      /note="primer"
      /organism="Artificial Sequence"

<400> 41
ccttacgcgt gaatctccac cagtagaa                                       28


<210> 42
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..31
<223> /mol_type="unassigned DNA"
      /note="primer"
      /organism="Artificial Sequence"

<400> 42
ccttgcgcgc ctggttggtt cggtttaaga c                                   31


<210> 43
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..39
<223> /mol_type="unassigned DNA"
      /note="primer"
      /organism="Artificial Sequence"

<400> 43
ccttgctagc tgcgcgcgaa taagtggcaa tggtagaac                            39


<210> 44
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="primer"
      /organism="Artificial Sequence"

<400> 44
ttcgataatg gaggcaagtc                                                20


<210> 45
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="primer"
      /organism="Artificial Sequence"

<400> 45
caagtttttg cggtttggtt                                                20


<210> 46
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="primer"
      /organism="Artificial Sequence"

<400> 46
taggcgttgg gccatattag                                                20


<210> 47
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned DNA"
      /note="primer"
      /organism="Artificial Sequence"

<400> 47
gcaattagct gtgcaaacca t                                              21


<210> 48
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..22
<223> /mol_type="unassigned DNA"
      /note="primer"
      /organism="Artificial Sequence"

<400> 48
catttgcaag actcagaaat ga                                             22


<210> 49
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..22
<223> /mol_type="unassigned DNA"
      /note="primer"
      /organism="Artificial Sequence"

<400> 49
tcgaaatgtt ttcattcctt cc                                             22


<210> 50
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..22
<223> /mol_type="unassigned DNA"
      /note="primer"
      /organism="Artificial Sequence"

<400> 50
ctgcaaggcg attaagttgg gt                                             22


<210> 51
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="primer"
      /organism="Artificial Sequence"

<400> 51
cttacctact gcttccagac                                                20


<210> 52
<211> 1095
<212> PRT
<213> Malus sp.

<220> 
<223> [CDS]:1..3288 from SEQ ID NO 3

<400> 52
Met Thr Ala His Glu Ala Ser Ser Ser Ser Ser Ser Lys Ser Lys Leu 
1               5                   10                  15      
Trp Ser Tyr Asp Val Phe Leu Ser Phe Arg Gly Glu Asp Thr Arg Asn 
            20                  25                  30          
Gly Phe Thr Ser His Leu His Glu Ala Leu Lys Tyr Arg Gly Tyr His 
        35                  40                  45              
Val Phe Ile Asp Glu Asp Gly Leu Lys Arg Gly Glu Glu Ile Lys Glu 
    50                  55                  60                  
Lys Leu Phe Arg Ala Ile Glu Glu Ser Arg Ile Ser Ile Ile Val Phe 
65                  70                  75                  80  
Ser Lys Met Tyr Ala Asp Ser Ser Trp Cys Leu Asp Glu Leu Val Lys 
                85                  90                  95      
Ile Met Glu Cys Arg Asp Lys Leu Gly Gln His Val Leu Pro Ile Phe 
            100                 105                 110         
Tyr His Val Asp Pro Ser His Val Arg Lys Gln Asp Gly Asp Leu Ala 
        115                 120                 125             
Glu Ala Phe Gln Lys His Glu Lys Asp Ile Arg Glu Glu Lys Asp Asp 
    130                 135                 140                 
Glu Lys Arg Glu Ala Lys Gln Lys Arg Ala Glu Gln Trp Lys Gly Ala 
145                 150                 155                 160 
Leu Thr Lys Ala Ala Asp Leu Ser Gly His His Leu Lys Ser Thr His 
                165                 170                 175     
Asn Arg Glu Arg Arg Arg Asp Pro Leu Thr Glu Ala Ala Asn Leu Ser 
            180                 185                 190         
Asp His Gln Thr Thr Asp Asn Gly Ser Arg Lys Gly Lys Thr Phe Pro 
        195                 200                 205             
Leu Arg Ile Thr Thr Phe Asn Arg Cys Glu Ala Lys Phe Ile Lys Lys 
    210                 215                 220                 
Ile Val Asp Glu Asn Ile Trp Glu Trp Leu Pro Arg Thr Asn Glu Leu 
225                 230                 235                 240 
His Val Ala Lys His Pro Ile Gly Ile Lys Ser Arg Ile Gln Gly Ile 
                245                 250                 255     
Ile Ser Asp Leu Ser Ser Gly Gly Ser Asn Asp Val Leu Met Val Gly 
            260                 265                 270         
Ile Trp Gly Met Gly Gly Leu Gly Lys Thr Thr Val Ala Lys Ala Ile 
        275                 280                 285             
Tyr Asn Gln Ile His Arg Lys Phe Glu Phe Lys Ser Phe Leu Ala Asp 
    290                 295                 300                 
Val Ser Asp Ala Thr Ser Lys His Gly Leu Val Tyr Leu Gln Glu Lys 
305                 310                 315                 320 
Leu Ile Ser Asp Ile Leu Lys Gln Lys Ser Gly Ser Ser Asn Phe Asp 
                325                 330                 335     
Glu Gly Ile Asn Leu Ile Lys Gln His Leu Gln Arg Arg Arg Val Leu 
            340                 345                 350         
Val Ile Ile Asp Asn Ile Asp Asp Leu Lys Gln Leu Asp Ala Ile Ala 
        355                 360                 365             
Val Ser His His Cys Phe Gly Pro Gly Ser Arg Ile Ile Ile Thr Thr 
    370                 375                 380                 
Arg Asn Glu His Leu Leu Lys Gln Val Glu Val Asp Lys Thr Tyr Pro 
385                 390                 395                 400 
Leu Gln Glu Met Lys Lys Lys Glu Ala Leu Glu Leu Phe Ser Trp His 
                405                 410                 415     
Ala Phe Arg Lys Ser Tyr Pro Asn Glu Glu Tyr Leu Glu Val Ser Glu 
            420                 425                 430         
Lys Val Val Ser Tyr Cys Gly Gly Leu Pro Leu Ala Leu Glu Val Leu 
        435                 440                 445             
Gly Ser Phe Leu Phe Lys Arg Pro Ile Ala Glu Trp Lys Ser Gln Leu 
    450                 455                 460                 
Lys Lys Leu Glu Arg Thr Pro Asn Gly Glu Ile Ile Lys Pro Leu Lys 
465                 470                 475                 480 
Ile Ser Phe Glu Gly Leu Asp Asp Thr Glu Lys Ala Ile Phe Leu Asp 
                485                 490                 495     
Ile Ser Cys Phe Phe Ile Gly Arg Asp Lys Asp Tyr Val Ala Lys Val 
            500                 505                 510         
Leu Asp Gly Cys Gly Phe Phe Ala Thr Gly Gly Ile Ser Val Leu Arg 
        515                 520                 525             
Glu Arg Cys Leu Val Thr Val Glu Gly Asn Lys Leu Thr Met His Asp 
    530                 535                 540                 
Leu Leu Arg Glu Met Ala Arg Val Ile Ile Ser Glu Lys Ser Leu Asp 
545                 550                 555                 560 
Cys Pro Gly Lys Trp Ser Arg Leu Trp Asn Arg Gln Glu Val Thr Asp 
                565                 570                 575     
Val Leu Thr Asn Lys Ser Gly Thr Gly Glu Ile Glu Gly Leu Ala Leu 
            580                 585                 590         
Tyr Phe Pro Lys Glu Thr Lys Ile Ala Ser Phe Ser Thr Lys Ala Phe 
        595                 600                 605             
Ala Ile Met Lys Lys Leu Ser Leu Leu Ala Leu Leu Phe Arg Lys Glu 
    610                 615                 620                 
Thr Lys Ile Ala Ser Phe Ser Thr Lys Ala Phe Ala Lys Met Lys Lys 
625                 630                 635                 640 
Leu Arg Leu Leu Gln Leu Ser Asn Val Glu Leu Lys Gly Glu Tyr Lys 
                645                 650                 655     
His Leu Pro Lys Glu Leu Ile Trp Leu Arg Trp Glu Gly Cys Pro Leu 
            660                 665                 670         
Lys Ser Leu Pro Asp Asp Phe Phe Asn Gln Pro Arg Leu Val Val Leu 
        675                 680                 685             
Glu Met Gln Cys Ser Lys Leu Val Gln Val Trp Lys Gly Phe Lys Ser 
    690                 695                 700                 
Leu His Asn Leu Lys Thr Leu Asp Leu Ser Trp Ser Asp Ser Leu Gln 
705                 710                 715                 720 
Lys Ser Pro Asp Phe Ser Gln Val Pro Asn Leu Glu Glu Leu Ile Leu 
                725                 730                 735     
Glu Ala Cys Ile Asn Leu Ser Glu Ile His Pro Ser Ile Gly His Leu 
            740                 745                 750         
Lys Arg Leu Ser Leu Val Asn Leu Lys Trp Cys Asn Lys Leu Ile Ser 
        755                 760                 765             
Leu Pro Arg Asp Phe Tyr Lys Leu Lys Ser Val Glu Thr Leu Leu Leu 
    770                 775                 780                 
Asn Asn Ser Tyr Gln Phe Arg Glu Val His Glu Asp Ile Gly Glu Met 
785                 790                 795                 800 
Ile Ser Leu Arg Thr Leu Glu Ala Arg Gly Thr Ala Ile Arg Glu Val 
                805                 810                 815     
Pro Pro Ser Ile Val Gly Leu Lys Asn Leu Thr Arg Leu Ser Leu Glu 
            820                 825                 830         
Gly Thr Met Arg Gly Ile Gln Leu Pro His Ser Leu Arg Glu Ile Asp 
        835                 840                 845             
Leu Thr Tyr Gly Ala Leu Asp Asp Ala Ile Lys Asp Leu Gly Ser Leu 
    850                 855                 860                 
Ile Tyr Leu Gln His Leu His Leu Gln Gly Asn Asn Phe His Ser Leu 
865                 870                 875                 880 
Pro Asn Leu Ser Gly Leu Leu Lys Leu Glu Thr Leu Trp Leu Asn Gly 
                885                 890                 895     
Ser Glu Tyr Leu Arg Thr Ile Pro Asp Leu Pro Thr Asn Leu Lys Val 
            900                 905                 910         
Leu Phe Ala Asp Ala Cys Pro Ala Leu Glu Thr Met Pro Asp Phe Ser 
        915                 920                 925             
Glu Met Ser Asn Met Arg Thr Leu Asp Val Ser His Ser Ala Lys Leu 
    930                 935                 940                 
Thr Gly Val Pro Gly Leu Asp Lys Ser Leu Asn Ser Met Val Trp Leu 
945                 950                 955                 960 
Asp Met His Arg Cys Pro Asn Leu Thr Ala Asp Phe Arg Lys Asn Ile 
                965                 970                 975     
Leu Gln Gly Trp Thr Ser Cys Gly Phe Gly Gly Ile Ala Leu His Gly 
            980                 985                 990         
Asn Tyr Val Pro Asp Trp Phe Glu Phe Ile Asn Glu Gly Thr Lys Arg 
        995                 1000                1005            
Thr Lys Leu Arg Ala Tyr Lys Thr Lys Ala Ser Tyr Thr Ile Asp Glu 
    1010                1015                1020                
Asn Tyr Glu Asn Asp His Leu Trp Gln Gly Gln Phe Ser Asn Asn Glu 
1025                1030                1035                1040
Leu Asn Leu Gln Gly Gly Asp Lys Val Asp Ile Val Phe Glu Asn Leu 
                1045                1050                1055    
Asp Glu Asp Asp Ser Val Lys Met Met Arg Thr Gly Val Asn Leu Val 
            1060                1065                1070        
Trp Asp Lys Leu Met Lys Glu Asn Met His Asp Leu Gly Asp Thr Arg 
        1075                1080                1085            
Gly Arg Ile Ser Phe Gly Ile 
    1090                1095

<210> 53
<211> 1095
<212> PRT
<213> Malus sp.

<220> 
<223> [CDS]:join(3963..4496,4597..4661,5976..6025,6224..7321,7533..7894
      ,8016..8841,8933..9018,9145..9411) from SEQ ID NO 2

<400> 53
Met Thr Ala His Glu Ala Ser Ser Ser Ser Ser Ser Lys Ser Lys Leu 
1               5                   10                  15      
Trp Ser Tyr Asp Val Phe Leu Ser Phe Arg Gly Glu Asp Thr Arg Asn 
            20                  25                  30          
Gly Phe Thr Ser His Leu His Glu Ala Leu Lys Tyr Arg Gly Tyr His 
        35                  40                  45              
Val Phe Ile Asp Glu Asp Gly Leu Lys Arg Gly Glu Glu Ile Lys Glu 
    50                  55                  60                  
Lys Leu Phe Arg Ala Ile Glu Glu Ser Arg Ile Ser Ile Ile Val Phe 
65                  70                  75                  80  
Ser Lys Met Tyr Ala Asp Ser Ser Trp Cys Leu Asp Glu Leu Val Lys 
                85                  90                  95      
Ile Met Glu Cys Arg Asp Lys Leu Gly Gln His Val Leu Pro Ile Phe 
            100                 105                 110         
Tyr His Val Asp Pro Ser His Val Arg Lys Gln Asp Gly Asp Leu Ala 
        115                 120                 125             
Glu Ala Phe Gln Lys His Glu Lys Asp Ile Arg Glu Glu Lys Asp Asp 
    130                 135                 140                 
Glu Lys Arg Glu Ala Lys Gln Lys Arg Ala Glu Gln Trp Lys Gly Ala 
145                 150                 155                 160 
Leu Thr Lys Ala Ala Asp Leu Ser Gly His His Leu Lys Ser Thr His 
                165                 170                 175     
Asn Arg Glu Arg Arg Arg Asp Pro Leu Thr Glu Ala Ala Asn Leu Ser 
            180                 185                 190         
Asp His Gln Thr Thr Asp Asn Gly Ser Arg Lys Gly Lys Thr Phe Pro 
        195                 200                 205             
Leu Arg Ile Thr Thr Phe Asn Arg Cys Glu Ala Lys Phe Ile Lys Lys 
    210                 215                 220                 
Ile Val Asp Glu Asn Ile Trp Glu Trp Leu Pro Arg Thr Asn Glu Leu 
225                 230                 235                 240 
His Val Ala Lys His Pro Ile Gly Ile Lys Ser Arg Ile Gln Gly Ile 
                245                 250                 255     
Ile Ser Asp Leu Ser Ser Gly Gly Ser Asn Asp Val Leu Met Val Gly 
            260                 265                 270         
Ile Trp Gly Met Gly Gly Leu Gly Lys Thr Thr Val Ala Lys Ala Ile 
        275                 280                 285             
Tyr Asn Gln Ile His Arg Lys Phe Glu Phe Lys Ser Phe Leu Ala Asp 
    290                 295                 300                 
Val Ser Asp Ala Thr Ser Lys His Gly Leu Val Tyr Leu Gln Glu Lys 
305                 310                 315                 320 
Leu Ile Ser Asp Ile Leu Lys Gln Lys Ser Gly Ser Ser Asn Phe Asp 
                325                 330                 335     
Glu Gly Ile Asn Leu Ile Lys Gln His Leu Gln Arg Arg Arg Val Leu 
            340                 345                 350         
Val Ile Ile Asp Asn Ile Asp Asp Leu Lys Gln Leu Asp Ala Ile Ala 
        355                 360                 365             
Val Ser His His Cys Phe Gly Pro Gly Ser Arg Ile Ile Ile Thr Thr 
    370                 375                 380                 
Arg Asn Glu His Leu Leu Lys Gln Val Glu Val Asp Lys Thr Tyr Pro 
385                 390                 395                 400 
Leu Gln Glu Met Lys Lys Lys Glu Ala Leu Glu Leu Phe Ser Trp His 
                405                 410                 415     
Ala Phe Arg Lys Ser Tyr Pro Asn Glu Glu Tyr Leu Glu Val Ser Glu 
            420                 425                 430         
Lys Val Val Ser Tyr Cys Gly Gly Leu Pro Leu Ala Leu Glu Val Leu 
        435                 440                 445             
Gly Ser Phe Leu Phe Lys Arg Pro Ile Ala Glu Trp Lys Ser Gln Leu 
    450                 455                 460                 
Lys Lys Leu Glu Arg Thr Pro Asn Gly Glu Ile Ile Lys Pro Leu Lys 
465                 470                 475                 480 
Ile Ser Phe Glu Gly Leu Asp Asp Thr Glu Lys Ala Ile Phe Leu Asp 
                485                 490                 495     
Ile Ser Cys Phe Phe Ile Gly Arg Asp Lys Asp Tyr Val Ala Lys Val 
            500                 505                 510         
Leu Asp Gly Cys Gly Phe Phe Ala Thr Gly Gly Ile Ser Val Leu Arg 
        515                 520                 525             
Glu Arg Cys Leu Val Thr Val Glu Gly Asn Lys Leu Thr Met His Asp 
    530                 535                 540                 
Leu Leu Arg Glu Met Ala Arg Val Ile Ile Ser Glu Lys Ser Leu Asp 
545                 550                 555                 560 
Cys Pro Gly Lys Trp Ser Arg Leu Trp Asn Arg Gln Glu Val Thr Asp 
                565                 570                 575     
Val Leu Thr Asn Lys Ser Gly Thr Gly Glu Ile Glu Gly Leu Ala Leu 
            580                 585                 590         
Tyr Phe Pro Lys Glu Thr Lys Ile Ala Ser Phe Ser Thr Lys Ala Phe 
        595                 600                 605             
Ala Ile Met Lys Lys Leu Ser Leu Leu Ala Leu Leu Phe Arg Lys Glu 
    610                 615                 620                 
Thr Lys Ile Ala Ser Phe Ser Thr Lys Ala Phe Ala Lys Met Lys Lys 
625                 630                 635                 640 
Leu Arg Leu Leu Gln Leu Ser Asn Val Glu Leu Lys Gly Glu Tyr Lys 
                645                 650                 655     
His Leu Pro Lys Glu Leu Ile Trp Leu Arg Trp Glu Gly Cys Pro Leu 
            660                 665                 670         
Lys Ser Leu Pro Asp Asp Phe Phe Asn Gln Pro Arg Leu Val Val Leu 
        675                 680                 685             
Glu Met Gln Cys Ser Lys Leu Val Gln Val Trp Lys Gly Phe Lys Ser 
    690                 695                 700                 
Leu His Asn Leu Lys Thr Leu Asp Leu Ser Trp Ser Asp Ser Leu Gln 
705                 710                 715                 720 
Lys Ser Pro Asp Phe Ser Gln Val Pro Asn Leu Glu Glu Leu Ile Leu 
                725                 730                 735     
Glu Ala Cys Ile Asn Leu Ser Glu Ile His Pro Ser Ile Gly His Leu 
            740                 745                 750         
Lys Arg Leu Ser Leu Val Asn Leu Lys Trp Cys Asn Lys Leu Ile Ser 
        755                 760                 765             
Leu Pro Arg Asp Phe Tyr Lys Leu Lys Ser Val Glu Thr Leu Leu Leu 
    770                 775                 780                 
Asn Asn Ser Tyr Gln Phe Arg Glu Val His Glu Asp Ile Gly Glu Met 
785                 790                 795                 800 
Ile Ser Leu Arg Thr Leu Glu Ala Arg Gly Thr Ala Ile Arg Glu Val 
                805                 810                 815     
Pro Pro Ser Ile Val Gly Leu Lys Asn Leu Thr Arg Leu Ser Leu Glu 
            820                 825                 830         
Gly Thr Met Arg Gly Ile Gln Leu Pro His Ser Leu Arg Glu Ile Asp 
        835                 840                 845             
Leu Thr Tyr Gly Ala Leu Asp Asp Ala Ile Lys Asp Leu Gly Ser Leu 
    850                 855                 860                 
Ile Tyr Leu Gln His Leu His Leu Gln Gly Asn Asn Phe His Ser Leu 
865                 870                 875                 880 
Pro Asn Leu Ser Gly Leu Leu Lys Leu Glu Thr Leu Trp Leu Asn Gly 
                885                 890                 895     
Ser Glu Tyr Leu Arg Thr Ile Pro Asp Leu Pro Thr Asn Leu Lys Val 
            900                 905                 910         
Leu Phe Ala Asp Ala Cys Pro Ala Leu Glu Thr Met Pro Asp Phe Ser 
        915                 920                 925             
Glu Met Ser Asn Met Arg Thr Leu Asp Val Ser His Ser Ala Lys Leu 
    930                 935                 940                 
Thr Gly Val Pro Gly Leu Asp Lys Ser Leu Asn Ser Met Val Trp Leu 
945                 950                 955                 960 
Asp Met His Arg Cys Pro Asn Leu Thr Ala Asp Phe Arg Lys Asn Ile 
                965                 970                 975     
Leu Gln Gly Trp Thr Ser Cys Gly Phe Gly Gly Ile Ala Leu His Gly 
            980                 985                 990         
Asn Tyr Val Pro Asp Trp Phe Glu Phe Ile Asn Glu Gly Thr Lys Arg 
        995                 1000                1005            
Thr Lys Leu Arg Ala Tyr Lys Thr Lys Ala Ser Tyr Thr Ile Asp Glu 
    1010                1015                1020                
Asn Tyr Glu Asn Asp His Leu Trp Gln Gly Gln Phe Ser Asn Asn Glu 
1025                1030                1035                1040
Leu Asn Leu Gln Gly Gly Asp Lys Val Asp Ile Val Phe Glu Asn Leu 
                1045                1050                1055    
Asp Glu Asp Asp Ser Val Lys Met Met Arg Thr Gly Val Asn Leu Val 
            1060                1065                1070        
Trp Asp Lys Leu Met Lys Glu Asn Met His Asp Leu Gly Asp Thr Arg 
        1075                1080                1085            
Gly Arg Ile Ser Phe Gly Ile 
    1090                1095

