                         SEQUENCE LISTING

<110>  UNIVERSITT HAMBURG
 
<120>  MITTEL UND VERFAHREN ZUR MODIFIZIERUNG DER 5'-KAPPE VON RNA

<130>  PAT 1439 PCT

<150>  DE102012222675.3
<151>  2012-12-10

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  258
<212>  PRT
<213>  Giardia lamblia

<400>  1

Met Ser Thr Trp Leu Leu Asp Ser Lys Cys Val Glu Arg Met Lys Trp 
1               5                   10                  15      


Leu Phe Ser Asp Leu Pro Glu Glu Lys Arg Val Met Ile Lys Met Asn 
            20                  25                  30          


Glu Val Ala Phe Phe Ser Val Thr Pro Ala Val Tyr Ala Asp Glu Val 
        35                  40                  45              


Ala Arg Met Met Arg Thr Val Leu Ala Leu Leu Gly Lys Pro Pro Tyr 
    50                  55                  60                  


Ala Val Ile Asp Gly Thr Ala Cys Val Gly Gly Asp Thr Arg Leu Leu 
65                  70                  75                  80  


Ala Lys His Phe Asp Met Thr Val Ala Ile Glu Arg Asp Pro Glu Thr 
                85                  90                  95      


Tyr Ala Leu Leu Gln Asp Asn Leu Thr Thr Trp Gly Val Asp Ala Lys 
            100                 105                 110         


Thr Ile Ser Gly Asp Thr Ala Ala Leu Ile Pro Gln Phe Trp Thr Leu 
        115                 120                 125             


Ile Gly Ala Val Ala Thr Phe Ser Leu Tyr Leu Asp Pro Pro Trp Gly 
    130                 135                 140                 


Gly Val Asp Tyr Arg Ser Gln Thr Asp Ile Gln Leu Thr Leu Gly Ser 
145                 150                 155                 160 


Leu Ala Val Glu Asp Val Val Asn Arg Ala Phe Glu Ala His Leu Ser 
                165                 170                 175     


Met Lys Leu Ala Val Leu Lys Leu Pro Arg Asn Tyr Asn Cys Gly Tyr 
            180                 185                 190         


Leu Phe Arg Lys Leu Gly Lys His Glu Val Phe Arg Ile Thr Gln Gly 
        195                 200                 205             


Asn Phe Phe Val Phe Phe Val Ala Arg Arg Gly Ser Arg Val Lys Glu 
    210                 215                 220                 


His Gly Arg Thr Ala Met Leu Gln Leu Arg Lys Ala Arg Glu Glu Ala 
225                 230                 235                 240 


Lys Ala Arg Ser Glu Glu Thr Lys Glu Asp Gly Glu Thr Arg Gly Ser 
                245                 250                 255     


Gly Glu 
        


<210>  2
<211>  258
<212>  PRT
<213>  Giardia lamblia


<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = any amino acid except valine (Val); preferably Ala, Gly, 
       Met

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  Xaa = any amino acid, preferably Asp, Thr, Leu or Val

<220>
<221>  MISC_FEATURE
<222>  (92)..(92)
<223>  Xaa = any amino acid, preferably Arg or Ala

<400>  2

Met Ser Thr Trp Leu Leu Asp Ser Lys Cys Val Glu Arg Met Lys Trp 
1               5                   10                  15      


Leu Phe Ser Asp Leu Pro Glu Glu Lys Arg Val Met Ile Lys Met Asn 
            20                  25                  30          


Glu Xaa Ala Phe Phe Ser Val Thr Pro Ala Val Tyr Ala Asp Glu Val 
        35                  40                  45              


Ala Arg Met Met Arg Thr Val Leu Ala Leu Leu Gly Lys Pro Pro Tyr 
    50                  55                  60                  


Ala Val Ile Asp Gly Thr Ala Cys Val Gly Gly Xaa Thr Arg Leu Leu 
65                  70                  75                  80  


Ala Lys His Phe Asp Met Thr Val Ala Ile Glu Xaa Asp Pro Glu Thr 
                85                  90                  95      


Tyr Ala Leu Leu Gln Asp Asn Leu Thr Thr Trp Gly Val Asp Ala Lys 
            100                 105                 110         


Thr Ile Ser Gly Asp Thr Ala Ala Leu Ile Pro Gln Phe Trp Thr Leu 
        115                 120                 125             


Ile Gly Ala Val Ala Thr Phe Ser Leu Tyr Leu Asp Pro Pro Trp Gly 
    130                 135                 140                 


Gly Val Asp Tyr Arg Ser Gln Thr Asp Ile Gln Leu Thr Leu Gly Ser 
145                 150                 155                 160 


Leu Ala Val Glu Asp Val Val Asn Arg Ala Phe Glu Ala His Leu Ser 
                165                 170                 175     


Met Lys Leu Ala Val Leu Lys Leu Pro Arg Asn Tyr Asn Cys Gly Tyr 
            180                 185                 190         


Leu Phe Arg Lys Leu Gly Lys His Glu Val Phe Arg Ile Thr Gln Gly 
        195                 200                 205             


Asn Phe Phe Val Phe Phe Val Ala Arg Arg Gly Ser Arg Val Lys Glu 
    210                 215                 220                 


His Gly Arg Thr Ala Met Leu Gln Leu Arg Lys Ala Arg Glu Glu Ala 
225                 230                 235                 240 


Lys Ala Arg Ser Glu Glu Thr Lys Glu Asp Gly Glu Thr Arg Gly Ser 
                245                 250                 255     


Gly Glu 
        


<210>  3
<211>  258
<212>  PRT
<213>  Giardia lamblia


<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = Ala, Gly or Met

<220>
<221>  MISC_FEATURE
<222>  (92)..(92)
<223>  Xaa = Arg or Ala

<400>  3

Met Ser Thr Trp Leu Leu Asp Ser Lys Cys Val Glu Arg Met Lys Trp 
1               5                   10                  15      


Leu Phe Ser Asp Leu Pro Glu Glu Lys Arg Val Met Ile Lys Met Asn 
            20                  25                  30          


Glu Xaa Ala Phe Phe Ser Val Thr Pro Ala Val Tyr Ala Asp Glu Val 
        35                  40                  45              


Ala Arg Met Met Arg Thr Val Leu Ala Leu Leu Gly Lys Pro Pro Tyr 
    50                  55                  60                  


Ala Val Ile Asp Gly Thr Ala Cys Val Gly Gly Asp Thr Arg Leu Leu 
65                  70                  75                  80  


Ala Lys His Phe Asp Met Thr Val Ala Ile Glu Xaa Asp Pro Glu Thr 
                85                  90                  95      


Tyr Ala Leu Leu Gln Asp Asn Leu Thr Thr Trp Gly Val Asp Ala Lys 
            100                 105                 110         


Thr Ile Ser Gly Asp Thr Ala Ala Leu Ile Pro Gln Phe Trp Thr Leu 
        115                 120                 125             


Ile Gly Ala Val Ala Thr Phe Ser Leu Tyr Leu Asp Pro Pro Trp Gly 
    130                 135                 140                 


Gly Val Asp Tyr Arg Ser Gln Thr Asp Ile Gln Leu Thr Leu Gly Ser 
145                 150                 155                 160 


Leu Ala Val Glu Asp Val Val Asn Arg Ala Phe Glu Ala His Leu Ser 
                165                 170                 175     


Met Lys Leu Ala Val Leu Lys Leu Pro Arg Asn Tyr Asn Cys Gly Tyr 
            180                 185                 190         


Leu Phe Arg Lys Leu Gly Lys His Glu Val Phe Arg Ile Thr Gln Gly 
        195                 200                 205             


Asn Phe Phe Val Phe Phe Val Ala Arg Arg Gly Ser Arg Val Lys Glu 
    210                 215                 220                 


His Gly Arg Thr Ala Met Leu Gln Leu Arg Lys Ala Arg Glu Glu Ala 
225                 230                 235                 240 


Lys Ala Arg Ser Glu Glu Thr Lys Glu Asp Gly Glu Thr Arg Gly Ser 
                245                 250                 255     


Gly Glu 
        


<210>  4
<211>  258
<212>  PRT
<213>  Giardia lamblia

<400>  4

Met Ser Thr Trp Leu Leu Asp Ser Lys Cys Val Glu Arg Met Lys Trp 
1               5                   10                  15      


Leu Phe Ser Asp Leu Pro Glu Glu Lys Arg Val Met Ile Lys Met Asn 
            20                  25                  30          


Glu Ala Ala Phe Phe Ser Val Thr Pro Ala Val Tyr Ala Asp Glu Val 
        35                  40                  45              


Ala Arg Met Met Arg Thr Val Leu Ala Leu Leu Gly Lys Pro Pro Tyr 
    50                  55                  60                  


Ala Val Ile Asp Gly Thr Ala Cys Val Gly Gly Asp Thr Arg Leu Leu 
65                  70                  75                  80  


Ala Lys His Phe Asp Met Thr Val Ala Ile Glu Arg Asp Pro Glu Thr 
                85                  90                  95      


Tyr Ala Leu Leu Gln Asp Asn Leu Thr Thr Trp Gly Val Asp Ala Lys 
            100                 105                 110         


Thr Ile Ser Gly Asp Thr Ala Ala Leu Ile Pro Gln Phe Trp Thr Leu 
        115                 120                 125             


Ile Gly Ala Val Ala Thr Phe Ser Leu Tyr Leu Asp Pro Pro Trp Gly 
    130                 135                 140                 


Gly Val Asp Tyr Arg Ser Gln Thr Asp Ile Gln Leu Thr Leu Gly Ser 
145                 150                 155                 160 


Leu Ala Val Glu Asp Val Val Asn Arg Ala Phe Glu Ala His Leu Ser 
                165                 170                 175     


Met Lys Leu Ala Val Leu Lys Leu Pro Arg Asn Tyr Asn Cys Gly Tyr 
            180                 185                 190         


Leu Phe Arg Lys Leu Gly Lys His Glu Val Phe Arg Ile Thr Gln Gly 
        195                 200                 205             


Asn Phe Phe Val Phe Phe Val Ala Arg Arg Gly Ser Arg Val Lys Glu 
    210                 215                 220                 


His Gly Arg Thr Ala Met Leu Gln Leu Arg Lys Ala Arg Glu Glu Ala 
225                 230                 235                 240 


Lys Ala Arg Ser Glu Glu Thr Lys Glu Asp Gly Glu Thr Arg Gly Ser 
                245                 250                 255     


Gly Glu 
        


<210>  5
<211>  258
<212>  PRT
<213>  Giardia lamblia

<400>  5

Met Ser Thr Trp Leu Leu Asp Ser Lys Cys Val Glu Arg Met Lys Trp 
1               5                   10                  15      


Leu Phe Ser Asp Leu Pro Glu Glu Lys Arg Val Met Ile Lys Met Asn 
            20                  25                  30          


Glu Gly Ala Phe Phe Ser Val Thr Pro Ala Val Tyr Ala Asp Glu Val 
        35                  40                  45              


Ala Arg Met Met Arg Thr Val Leu Ala Leu Leu Gly Lys Pro Pro Tyr 
    50                  55                  60                  


Ala Val Ile Asp Gly Thr Ala Cys Val Gly Gly Asp Thr Arg Leu Leu 
65                  70                  75                  80  


Ala Lys His Phe Asp Met Thr Val Ala Ile Glu Arg Asp Pro Glu Thr 
                85                  90                  95      


Tyr Ala Leu Leu Gln Asp Asn Leu Thr Thr Trp Gly Val Asp Ala Lys 
            100                 105                 110         


Thr Ile Ser Gly Asp Thr Ala Ala Leu Ile Pro Gln Phe Trp Thr Leu 
        115                 120                 125             


Ile Gly Ala Val Ala Thr Phe Ser Leu Tyr Leu Asp Pro Pro Trp Gly 
    130                 135                 140                 


Gly Val Asp Tyr Arg Ser Gln Thr Asp Ile Gln Leu Thr Leu Gly Ser 
145                 150                 155                 160 


Leu Ala Val Glu Asp Val Val Asn Arg Ala Phe Glu Ala His Leu Ser 
                165                 170                 175     


Met Lys Leu Ala Val Leu Lys Leu Pro Arg Asn Tyr Asn Cys Gly Tyr 
            180                 185                 190         


Leu Phe Arg Lys Leu Gly Lys His Glu Val Phe Arg Ile Thr Gln Gly 
        195                 200                 205             


Asn Phe Phe Val Phe Phe Val Ala Arg Arg Gly Ser Arg Val Lys Glu 
    210                 215                 220                 


His Gly Arg Thr Ala Met Leu Gln Leu Arg Lys Ala Arg Glu Glu Ala 
225                 230                 235                 240 


Lys Ala Arg Ser Glu Glu Thr Lys Glu Asp Gly Glu Thr Arg Gly Ser 
                245                 250                 255     


Gly Glu 
        


<210>  6
<211>  258
<212>  PRT
<213>  Giardia lamblia

<400>  6

Met Ser Thr Trp Leu Leu Asp Ser Lys Cys Val Glu Arg Met Lys Trp 
1               5                   10                  15      


Leu Phe Ser Asp Leu Pro Glu Glu Lys Arg Val Met Ile Lys Met Asn 
            20                  25                  30          


Glu Met Ala Phe Phe Ser Val Thr Pro Ala Val Tyr Ala Asp Glu Val 
        35                  40                  45              


Ala Arg Met Met Arg Thr Val Leu Ala Leu Leu Gly Lys Pro Pro Tyr 
    50                  55                  60                  


Ala Val Ile Asp Gly Thr Ala Cys Val Gly Gly Asp Thr Arg Leu Leu 
65                  70                  75                  80  


Ala Lys His Phe Asp Met Thr Val Ala Ile Glu Arg Asp Pro Glu Thr 
                85                  90                  95      


Tyr Ala Leu Leu Gln Asp Asn Leu Thr Thr Trp Gly Val Asp Ala Lys 
            100                 105                 110         


Thr Ile Ser Gly Asp Thr Ala Ala Leu Ile Pro Gln Phe Trp Thr Leu 
        115                 120                 125             


Ile Gly Ala Val Ala Thr Phe Ser Leu Tyr Leu Asp Pro Pro Trp Gly 
    130                 135                 140                 


Gly Val Asp Tyr Arg Ser Gln Thr Asp Ile Gln Leu Thr Leu Gly Ser 
145                 150                 155                 160 


Leu Ala Val Glu Asp Val Val Asn Arg Ala Phe Glu Ala His Leu Ser 
                165                 170                 175     


Met Lys Leu Ala Val Leu Lys Leu Pro Arg Asn Tyr Asn Cys Gly Tyr 
            180                 185                 190         


Leu Phe Arg Lys Leu Gly Lys His Glu Val Phe Arg Ile Thr Gln Gly 
        195                 200                 205             


Asn Phe Phe Val Phe Phe Val Ala Arg Arg Gly Ser Arg Val Lys Glu 
    210                 215                 220                 


His Gly Arg Thr Ala Met Leu Gln Leu Arg Lys Ala Arg Glu Glu Ala 
225                 230                 235                 240 


Lys Ala Arg Ser Glu Glu Thr Lys Glu Asp Gly Glu Thr Arg Gly Ser 
                245                 250                 255     


Gly Glu 
        


<210>  7
<211>  258
<212>  PRT
<213>  Giardia lamblia

<400>  7

Met Ser Thr Trp Leu Leu Asp Ser Lys Cys Val Glu Arg Met Lys Trp 
1               5                   10                  15      


Leu Phe Ser Asp Leu Pro Glu Glu Lys Arg Val Met Ile Lys Met Asn 
            20                  25                  30          


Glu Ala Ala Phe Phe Ser Val Thr Pro Ala Val Tyr Ala Asp Glu Val 
        35                  40                  45              


Ala Arg Met Met Arg Thr Val Leu Ala Leu Leu Gly Lys Pro Pro Tyr 
    50                  55                  60                  


Ala Val Ile Asp Gly Thr Ala Cys Val Gly Gly Thr Thr Arg Leu Leu 
65                  70                  75                  80  


Ala Lys His Phe Asp Met Thr Val Ala Ile Glu Arg Asp Pro Glu Thr 
                85                  90                  95      


Tyr Ala Leu Leu Gln Asp Asn Leu Thr Thr Trp Gly Val Asp Ala Lys 
            100                 105                 110         


Thr Ile Ser Gly Asp Thr Ala Ala Leu Ile Pro Gln Phe Trp Thr Leu 
        115                 120                 125             


Ile Gly Ala Val Ala Thr Phe Ser Leu Tyr Leu Asp Pro Pro Trp Gly 
    130                 135                 140                 


Gly Val Asp Tyr Arg Ser Gln Thr Asp Ile Gln Leu Thr Leu Gly Ser 
145                 150                 155                 160 


Leu Ala Val Glu Asp Val Val Asn Arg Ala Phe Glu Ala His Leu Ser 
                165                 170                 175     


Met Lys Leu Ala Val Leu Lys Leu Pro Arg Asn Tyr Asn Cys Gly Tyr 
            180                 185                 190         


Leu Phe Arg Lys Leu Gly Lys His Glu Val Phe Arg Ile Thr Gln Gly 
        195                 200                 205             


Asn Phe Phe Val Phe Phe Val Ala Arg Arg Gly Ser Arg Val Lys Glu 
    210                 215                 220                 


His Gly Arg Thr Ala Met Leu Gln Leu Arg Lys Ala Arg Glu Glu Ala 
225                 230                 235                 240 


Lys Ala Arg Ser Glu Glu Thr Lys Glu Asp Gly Glu Thr Arg Gly Ser 
                245                 250                 255     


Gly Glu 
        


<210>  8
<211>  258
<212>  PRT
<213>  Giardia lamblia

<400>  8

Met Ser Thr Trp Leu Leu Asp Ser Lys Cys Val Glu Arg Met Lys Trp 
1               5                   10                  15      


Leu Phe Ser Asp Leu Pro Glu Glu Lys Arg Val Met Ile Lys Met Asn 
            20                  25                  30          


Glu Ala Ala Phe Phe Ser Val Thr Pro Ala Val Tyr Ala Asp Glu Val 
        35                  40                  45              


Ala Arg Met Met Arg Thr Val Leu Ala Leu Leu Gly Lys Pro Pro Tyr 
    50                  55                  60                  


Ala Val Ile Asp Gly Thr Ala Cys Val Gly Gly Leu Thr Arg Leu Leu 
65                  70                  75                  80  


Ala Lys His Phe Asp Met Thr Val Ala Ile Glu Arg Asp Pro Glu Thr 
                85                  90                  95      


Tyr Ala Leu Leu Gln Asp Asn Leu Thr Thr Trp Gly Val Asp Ala Lys 
            100                 105                 110         


Thr Ile Ser Gly Asp Thr Ala Ala Leu Ile Pro Gln Phe Trp Thr Leu 
        115                 120                 125             


Ile Gly Ala Val Ala Thr Phe Ser Leu Tyr Leu Asp Pro Pro Trp Gly 
    130                 135                 140                 


Gly Val Asp Tyr Arg Ser Gln Thr Asp Ile Gln Leu Thr Leu Gly Ser 
145                 150                 155                 160 


Leu Ala Val Glu Asp Val Val Asn Arg Ala Phe Glu Ala His Leu Ser 
                165                 170                 175     


Met Lys Leu Ala Val Leu Lys Leu Pro Arg Asn Tyr Asn Cys Gly Tyr 
            180                 185                 190         


Leu Phe Arg Lys Leu Gly Lys His Glu Val Phe Arg Ile Thr Gln Gly 
        195                 200                 205             


Asn Phe Phe Val Phe Phe Val Ala Arg Arg Gly Ser Arg Val Lys Glu 
    210                 215                 220                 


His Gly Arg Thr Ala Met Leu Gln Leu Arg Lys Ala Arg Glu Glu Ala 
225                 230                 235                 240 


Lys Ala Arg Ser Glu Glu Thr Lys Glu Asp Gly Glu Thr Arg Gly Ser 
                245                 250                 255     


Gly Glu 
        


<210>  9
<211>  258
<212>  PRT
<213>  Giardia lamblia

<400>  9

Met Ser Thr Trp Leu Leu Asp Ser Lys Cys Val Glu Arg Met Lys Trp 
1               5                   10                  15      


Leu Phe Ser Asp Leu Pro Glu Glu Lys Arg Val Met Ile Lys Met Asn 
            20                  25                  30          


Glu Ala Ala Phe Phe Ser Val Thr Pro Ala Val Tyr Ala Asp Glu Val 
        35                  40                  45              


Ala Arg Met Met Arg Thr Val Leu Ala Leu Leu Gly Lys Pro Pro Tyr 
    50                  55                  60                  


Ala Val Ile Asp Gly Thr Ala Cys Val Gly Gly Val Thr Arg Leu Leu 
65                  70                  75                  80  


Ala Lys His Phe Asp Met Thr Val Ala Ile Glu Arg Asp Pro Glu Thr 
                85                  90                  95      


Tyr Ala Leu Leu Gln Asp Asn Leu Thr Thr Trp Gly Val Asp Ala Lys 
            100                 105                 110         


Thr Ile Ser Gly Asp Thr Ala Ala Leu Ile Pro Gln Phe Trp Thr Leu 
        115                 120                 125             


Ile Gly Ala Val Ala Thr Phe Ser Leu Tyr Leu Asp Pro Pro Trp Gly 
    130                 135                 140                 


Gly Val Asp Tyr Arg Ser Gln Thr Asp Ile Gln Leu Thr Leu Gly Ser 
145                 150                 155                 160 


Leu Ala Val Glu Asp Val Val Asn Arg Ala Phe Glu Ala His Leu Ser 
                165                 170                 175     


Met Lys Leu Ala Val Leu Lys Leu Pro Arg Asn Tyr Asn Cys Gly Tyr 
            180                 185                 190         


Leu Phe Arg Lys Leu Gly Lys His Glu Val Phe Arg Ile Thr Gln Gly 
        195                 200                 205             


Asn Phe Phe Val Phe Phe Val Ala Arg Arg Gly Ser Arg Val Lys Glu 
    210                 215                 220                 


His Gly Arg Thr Ala Met Leu Gln Leu Arg Lys Ala Arg Glu Glu Ala 
225                 230                 235                 240 


Lys Ala Arg Ser Glu Glu Thr Lys Glu Asp Gly Glu Thr Arg Gly Ser 
                245                 250                 255     


Gly Glu 
        


<210>  10
<211>  258
<212>  PRT
<213>  Giardia lamblia

<400>  10

Met Ser Thr Trp Leu Leu Asp Ser Lys Cys Val Glu Arg Met Lys Trp 
1               5                   10                  15      


Leu Phe Ser Asp Leu Pro Glu Glu Lys Arg Val Met Ile Lys Met Asn 
            20                  25                  30          


Glu Ala Ala Phe Phe Ser Val Thr Pro Ala Val Tyr Ala Asp Glu Val 
        35                  40                  45              


Ala Arg Met Met Arg Thr Val Leu Ala Leu Leu Gly Lys Pro Pro Tyr 
    50                  55                  60                  


Ala Val Ile Asp Gly Thr Ala Cys Val Gly Gly Asp Thr Arg Leu Leu 
65                  70                  75                  80  


Ala Lys His Phe Asp Met Thr Val Ala Ile Glu Ala Asp Pro Glu Thr 
                85                  90                  95      


Tyr Ala Leu Leu Gln Asp Asn Leu Thr Thr Trp Gly Val Asp Ala Lys 
            100                 105                 110         


Thr Ile Ser Gly Asp Thr Ala Ala Leu Ile Pro Gln Phe Trp Thr Leu 
        115                 120                 125             


Ile Gly Ala Val Ala Thr Phe Ser Leu Tyr Leu Asp Pro Pro Trp Gly 
    130                 135                 140                 


Gly Val Asp Tyr Arg Ser Gln Thr Asp Ile Gln Leu Thr Leu Gly Ser 
145                 150                 155                 160 


Leu Ala Val Glu Asp Val Val Asn Arg Ala Phe Glu Ala His Leu Ser 
                165                 170                 175     


Met Lys Leu Ala Val Leu Lys Leu Pro Arg Asn Tyr Asn Cys Gly Tyr 
            180                 185                 190         


Leu Phe Arg Lys Leu Gly Lys His Glu Val Phe Arg Ile Thr Gln Gly 
        195                 200                 205             


Asn Phe Phe Val Phe Phe Val Ala Arg Arg Gly Ser Arg Val Lys Glu 
    210                 215                 220                 


His Gly Arg Thr Ala Met Leu Gln Leu Arg Lys Ala Arg Glu Glu Ala 
225                 230                 235                 240 


Lys Ala Arg Ser Glu Glu Thr Lys Glu Asp Gly Glu Thr Arg Gly Ser 
                245                 250                 255     


Gly Glu 
        


<210>  11
<211>  243
<212>  PRT
<213>  Giardia intestinalis

<400>  11

Met Ser Glu Trp Pro Arg Asp Lys Lys Cys Val Glu Arg Met Lys Trp 
1               5                   10                  15      


Leu Phe Ser Asp Leu Pro Glu Glu Glu Arg Val Lys Val Lys Met Asn 
            20                  25                  30          


Glu Thr Ala Phe Phe Ser Val Thr Pro Ala Val Tyr Ala Glu Lys Val 
        35                  40                  45              


Ala Gly Met Met Arg Ala Val Leu Ala Leu Leu Gly Lys Ser Pro Tyr 
    50                  55                  60                  


Ala Val Ile Asp Gly Thr Ala Cys Val Gly Gly Asp Thr Arg Leu Leu 
65                  70                  75                  80  


Ala Lys His Phe Asp Leu Thr Val Ala Ile Glu Lys Asp Pro Glu Thr 
                85                  90                  95      


Tyr Thr Leu Leu Gln Asp Asn Leu Ser Thr Trp Gly Ile Asn Val Gln 
            100                 105                 110         


Thr Val Ser Gly Asp Thr Ser Ala Leu Ile Pro Gln Phe Trp Thr Leu 
        115                 120                 125             


Ile Gly Thr Val Ala Thr Phe Cys Leu Tyr Leu Asp Pro Pro Trp Gly 
    130                 135                 140                 


Gly Val Asp Tyr Arg Ser Gln Thr Asp Ile Gln Leu Thr Leu Gly Ser 
145                 150                 155                 160 


Leu Ala Val Glu Asp Val Ile Asn Arg Ala Phe Glu Ala His Leu Ser 
                165                 170                 175     


Met Lys Leu Ala Val Leu Lys Leu Pro Arg Asn Tyr Asn Cys Gly Tyr 
            180                 185                 190         


Leu Phe Arg Lys Leu Gly Lys His Glu Val Phe Arg Ile Thr Gln Gly 
        195                 200                 205             


Asn Phe Phe Val Phe Phe Val Ala Arg His Gly Ser Arg Val Lys Glu 
    210                 215                 220                 


His Cys Arg Ala Val Leu Ala Gln Ala Arg Lys Glu Lys Glu Ala Arg 
225                 230                 235                 240 


Glu Gly Gln 
            


