                         SEQUENCE LISTING

<110>  SIGMA-ALDRICH CO. LLC
       CHEN, Fuqiang
       DAVIS, Gregory D.
       KANG, Qiaohua
       KNIGHT, Scott W.
 
<120>  CRISPR-BASED GENOME MODIFICATION AND REGULATION

<130>  047497-465606

<150>  US 61/734,256
<151>  2012-12-06

<150>  US 61/758,624
<151>  2013-01-30

<150>  US 61/761,046
<151>  2013-02-05

<150>  US 61/794,422
<151>  2013-03-15

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  1

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  2

Pro Lys Lys Lys Arg Arg Val 
1               5           


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  3

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  4
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  4

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Pro Lys Lys 
1               5                   10                  15      


Lys Arg Lys Val 
            20  


<210>  5
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  5

Pro Leu Ser Ser Ile Phe Ser Arg Ile Gly Asp Pro Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val 
            


<210>  6
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  6

Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Pro Lys Lys Lys Arg Lys Val 
            20                  


<210>  7
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  7

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  8
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  8

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  9
<211>  1374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  9

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Gly Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Ile Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Ala Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Gly Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly His Ser Leu 
705                 710                 715                 720 


His Glu Gln Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Pro 
    1355                 1360                 1365             


Lys Lys  Lys Arg Lys Val 
    1370                 


<210>  10
<211>  4122
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  10
atggacaaga agtacagcat cggcctggac atcggcacca actctgtggg ctgggccgtg       60

atcaccgacg actacaaggt gcccagcaag aaattcaagg tgctgggcaa caccgaccgg      120

cacagcatca agaagaacct gatcggcgcc ctgctgttcg gctctggcga aacagccgag      180

gccacccggc tgaagagaac cgccagaaga agatacacca gacggaagaa ccggatctgc      240

tatctgcaag agatcttcag caacgagatg gccaaggtgg acgacagctt cttccacaga      300

ctggaagagt ccttcctggt ggaagaggat aagaagcacg agcggcaccc catcttcggc      360

aacatcgtgg acgaggtggc ctaccacgag aagtacccca ccatctacca cctgagaaag      420

aagctggccg acagcaccga caaggccgac ctgagactga tctacctggc cctggcccac      480

atgatcaagt tccggggcca cttcctgatc gagggcgacc tgaaccccga caacagcgac      540

gtggacaagc tgttcatcca gctggtgcag atctacaatc agctgttcga ggaaaacccc      600

atcaacgcca gcagagtgga cgccaaggcc atcctgagcg ccagactgag caagagcaga      660

cggctggaaa atctgatcgc ccagctgccc ggcgagaagc ggaatggcct gttcggcaac      720

ctgattgccc tgagcctggg cctgaccccc aacttcaaga gcaacttcga cctggccgag      780

gatgccaaac tgcagctgag caaggacacc tacgacgacg acctggacaa cctgctggcc      840

cagatcggcg accagtacgc cgacctgttt ctggccgcca agaacctgtc cgacgccatc      900

ctgctgagcg acatcctgag agtgaacagc gagatcacca aggcccccct gtccgcctct      960

atgatcaaga gatacgacga gcaccaccag gacctgaccc tgctgaaagc tctcgtgcgg     1020

cagcagctgc ctgagaagta caaagagatt ttcttcgacc agagcaagaa cggctacgcc     1080

ggctacatcg atggcggagc cagccaggaa gagttctaca agttcatcaa gcccatcctg     1140

gaaaagatgg acggcaccga ggaactgctc gtgaagctga acagagagga cctgctgcgg     1200

aagcagcgga ccttcgacaa cggcagcatc ccccaccaga tccacctggg agagctgcac     1260

gccattctgc ggcggcagga agatttttac ccattcctga aggacaaccg ggaaaagatc     1320

gagaagatcc tgaccttcag aatcccctac tacgtgggcc ctctggccag gggaaacagc     1380

agattcgcct ggatgaccag aaagagcgag gaaaccatca ccccctggaa cttcgaggaa     1440

gtggtggaca agggcgccag cgcccagagc ttcatcgagc ggatgaccaa cttcgataag     1500

aacctgccca acgagaaggt gctgcccaag cacagcctgc tgtacgagta cttcaccgtg     1560

tacaacgagc tgaccaaagt gaaatacgtg accgagggaa tgcggaagcc cgcctttctg     1620

agcggcgagc agaaaaaggc catcgtggac ctgctgttca agaccaaccg gaaagtgacc     1680

gtgaagcagc tgaaagagga ctacttcaag aaaatcgagt gcttcgacag cgtggaaatc     1740

agcggcgtgg aagatcggtt caacgcctcc ctgggcgcct atcacgatct gctgaaaatt     1800

atcaaggaca aggacttcct ggacaatgag gaaaacgagg acattctgga agatatcgtg     1860

ctgaccctga cactgtttga ggaccggggc atgatcgagg aacggctgaa aacctatgcc     1920

cacctgttcg acgacaaagt gatgaagcag ctgaagcggc ggagatacac cggctggggc     1980

aggctgagcc ggaagctgat caacggcatc cgggacaagc agtccggcaa gacaatcctg     2040

gatttcctga agtccgacgg cttcgccaac agaaacttca tgcagctgat ccacgacgac     2100

agcctgacct ttaaagagga catccagaaa gcccaggtgt ccggccaggg acactctctg     2160

cacgagcaga tcgccaatct ggccggatcc cccgccatta agaagggcat cctgcagaca     2220

gtgaagattg tggacgagct cgtgaaagtg atgggccaca agcccgagaa catcgtgatc     2280

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2340

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2400

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2460

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggaccacatt     2520

gtgccccagt ccttcatcaa ggacgactcc atcgataaca aagtgctgac tcggagcgac     2580

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2640

tactggcgcc agctgctgaa tgccaagctg attacccaga ggaagttcga caatctgacc     2700

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcattaa gcggcagctg     2760

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2820

aagtacgacg agaacgacaa actgatccgg gaagtgaaag tgatcaccct gaagtccaag     2880

ctggtgtccg acttcagaaa ggatttccag ttttacaaag tgcgcgagat caacaactac     2940

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3000

cctaagctgg aaagcgagtt cgtgtacggc gattacaagg tgtacgacgt gcggaagatg     3060

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3120

atcatgaact ttttcaagac cgagatcaca ctggccaacg gcgagatcag aaagcggcct     3180

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3240

acagtgcgga aagtgctgtc catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3300

accggcggct tcagcaaaga gtctatcctg cccaagagga actccgacaa gctgatcgcc     3360

agaaagaagg attgggaccc taagaagtac ggcggctttg acagccccac cgtggcctac     3420

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3480

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3540

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3600

tccctgttcg agctggaaaa cggccggaag cggatgctgg cttctgccgg cgaactgcag     3660

aagggaaacg agctggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3720

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3780

cacaagcact acctggacga gatcatcgag cagattagcg agttctccaa gcgcgtgatc     3840

ctggccgatg ccaacctgga caaggtgctg agcgcctaca acaagcaccg ggataagccc     3900

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaacct gggagcccct     3960

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4020

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4080

ctgtctcagc tgggaggcga ccccaagaaa aagcgcaaag tg                        4122


<210>  11
<211>  4764
<212>  DNA
<213>  Homo sapiens

<400>  11
gcgggcgggc ggtgcgatgt ccggagagga tggcccggcg gctggcccgg gggcggcggc       60

ggcggctgcc cgggagcggc gacgggagca gctgcggcag tggggggcgc gggcgggcgc      120

cgagcctggc cccggagagc gccgcgcccg caccgtccgc ttcgagcgcg ccgccgagtt      180

cctggcggcc tgtgcgggcg gcgacctgga cgaggcgcgt ctgatgctgc gcgccgccga      240

ccctggcccc ggcgccgagc tcgaccccgc cgcgccgccg cccgcccgcg ccgtgctgga      300

ctccaccaac gccgacggta tcagcgccct gcaccaggtc agcgcccccc gcccggcgtc      360

tcccggggcc aggtccaccc tctgctgcgc cacctggggc atcctccttc cccgttgcca      420

gtctcgatcc gccccgtcgt tcctggccct gggctttgcc accctatgct gacaccccgt      480

cccagtcccc cttaccattc cccttcgacc accccacttc cgaattggag ccgcttcaac      540

tggccctggg cttagccact ctgtgctgac cactctgccc caggcctcct taccattccc      600

cttcgaccta ctctcttccg cattggagtc gctttaactg gccctggctt tggcagcctg      660

tgctgaccca tgcagtcctc cttaccatcc ctccctcgac ttcccctctt ccgatgttga      720

gcccctccag ccggtcctgg actttgtctc cttccctgcc ctgccctctc ctgaacctga      780

gccagctccc atagctcagt ctggtctatc tgcctggccc tggccattgt cactttgcgc      840

tgccctcctc tcgcccccga gtgcccttgc tgtgccgccg gaactctgcc ctctaacgct      900

gccgtctctc tcctgagtcc ggaccacttt gagctctact ggcttctgcg ccgcctctgg      960

cccactgttt ccccttccca ggcaggtcct gctttctctg acctgcattc tctcccctgg     1020

gcctgtgccg ctttctgtct gcagcttgtg gcctgggtca cctctacggc tggcccagat     1080

ccttccctgc cgcctccttc aggttccgtc ttcctccact ccctcttccc cttgctctct     1140

gctgtgttgc tgcccaagga tgctctttcc ggagcacttc cttctcggcg ctgcaccacg     1200

tgatgtcctc tgagcggatc ctccccgtgt ctgggtcctc tccgggcatc tctcctccct     1260

cacccaaccc catgccgtct tcactcgctg ggttcccttt tccttctcct tctggggcct     1320

gtgccatctc tcgtttctta ggatggcctt ctccgacgga tgtctccctt gcgtcccgcc     1380

tccccttctt gtaggcctgc atcatcaccg tttttctgga caaccccaaa gtaccccgtc     1440

tccctggctt tagccacctc tccatcctct tgctttcttt gcctggacac cccgttctcc     1500

tgtggattcg ggtcacctct cactcctttc atttgggcag ctcccctacc ccccttacct     1560

ctctagtctg tgctagctct tccagccccc tgtcatggca tcttccaggg gtccgagagc     1620

tcagctagtc ttcttcctcc aacccgggcc cctatgtcca cttcaggaca gcatgtttgc     1680

tgcctccagg gatcctgtgt ccccgagctg ggaccacctt atattcccag ggccggttaa     1740

tgtggctctg gttctgggta cttttatctg tcccctccac cccacagtgg ggccactagg     1800

gacaggattg gtgacagaaa agccccatcc ttaggcctcc tccttcctag tctcctgata     1860

ttgggtctaa cccccacctc ctgttaggca gattccttat ctggtgacac acccccattt     1920

cctggagcca tctctctcct tgccagaacc tctaaggttt gcttacgatg gagccagaga     1980

ggatcctggg agggagagct tggcaggggg tgggagggaa gggggggatg cgtgacctgc     2040

ccggttctca gtggccaccc tgcgctaccc tctcccagaa cctgagctgc tctgacgcgg     2100

ccgtctggtg cgtttcactg atcctggtgc tgcagcttcc ttacacttcc caagaggaga     2160

agcagtttgg aaaaacaaaa tcagaataag ttggtcctga gttctaactt tggctcttca     2220

cctttctagt ccccaattta tattgttcct ccgtgcgtca gttttacctg tgagataagg     2280

ccagtagcca gccccgtcct ggcagggctg tggtgaggag gggggtgtcc gtgtggaaaa     2340

ctccctttgt gagaatggtg cgtcctaggt gttcaccagg tcgtggccgc ctctactccc     2400

tttctctttc tccatccttc tttccttaaa gagtccccag tgctatctgg gacatattcc     2460

tccgcccaga gcagggtccc gcttccctaa ggccctgctc tgggcttctg ggtttgagtc     2520

cttggcaagc ccaggagagg cgctcaggct tccctgtccc ccttcctcgt ccaccatctc     2580

atgcccctgg ctctcctgcc ccttccctac aggggttcct ggctctgctc ttcagactga     2640

gccccgttcc cctgcatccc cgttcccctg catccccctt cccctgcatc ccccagaggc     2700

cccaggccac ctacttggcc tggaccccac gagaggccac cccagccctg tctaccaggc     2760

tgccttttgg gtggattctc ctccaactgt ggggtgactg cttggcaaac tcactcttcg     2820

gggtatccca ggaggcctgg agcattgggg tgggctgggg ttcagagagg agggattccc     2880

ttctcaggtt acgtggccaa gaagcagggg agctgggttt gggtcaggtc tgggtgtggg     2940

gtgaccagct tatgctgttt gcccaggaca gcctagtttt agcactgaaa ccctcagtcc     3000

taggaaaaca gggatggttg gtcactgtct ctgggtgact cttgattccc ggccagtttc     3060

tccacctggg gctgtgtttc tcgtcctgca tccttctcca ggcaggtccc caagcatcgc     3120

ccccctgctg tggctgttcc caagttctta gggtacccca cgtgggttta tcaaccactt     3180

ggtgaggctg gtaccctgcc cccattcctg caccccaatt gccttagtgg ctagggggtt     3240

gggggctaga gtaggagggg ctggagccag gattcttagg gctgaacaga gaagagctgg     3300

gggcctgggc tcctgggttt gagagaggag gggctggggc ctggactcct gggtccgagg     3360

gaggaggggc tggggcctgg actcctgggt ctgagggtgg agggactggg ggcctggact     3420

cctgggtccg agggaggagg ggctggggcc tggactcgtg ggtctgaggg aggaggggct     3480

gggggcctgg acttctgggt cttagggagg cggggctggg cctggacccc tgggtctgaa     3540

tggggagagg ctgggggcct ggactccttc atctgagggc ggaagggctg gggcctggcc     3600

tcctgggttg aatggggagg ggttgggcct ggactctgga gtccctggtg cccaggcctc     3660

aggcatcttt cacagggatg cctgtactgg gcaggtcctt gaaagggaaa ggcccattgc     3720

tctccttgcc cccctcccct atcgccatga caactgggtg gaaataaacg agccgagttc     3780

atcccgttcc cagggcacgt gcggcccctt cacagcccga gtttccatga cctcatgctc     3840

ttggccctcg tagctccctc ccgcctcctc cagatgggca gctttggaga ggtgagggac     3900

ttggggggta atttatcccg tggatctagg agtttagctt cactccttcc tcagctccag     3960

ttcaggtccc ggagcccacc cagtgtccac aaggcctggg gcaagtccct cctccgaccc     4020

cctggacttc ggcttttgtc cccccaagtt ttggacccct aagggaagaa tgagaaacgg     4080

tggcccgtgt cagcccctgg ctgcagggcc ccgtgcagag ggggcctcag tgaactggag     4140

tgtgacagcc tggggcccag gcacacaggt gtgcagctgt ctcacccctc tgggagtccc     4200

gcccaggccc ctgagtctgt cccagcacag ggtggccttc ctccaccctg catagccctg     4260

ggcccacggc ttcgttcctg cagagtatct gctggggtgg tttccgagct tgacccttgg     4320

aaggacctgg ctgggtttaa ggcaggaggg gctgggggcc aggactcctg gctctgaagg     4380

aggaggggct ggaacctctt ccctagtctg agcactggaa gcgccacctg tgggtggtga     4440

cgggggtttt gccgtgtcta acaggtacca tgtggggttc ccgcacccag atgagaagcc     4500

ccctcccttc cccgttcact tcctgtttgc agatagccag gagtcctttc gtggtttcca     4560

ctgagcactg aaggcctggc cggcctgacc actgggcaac caggcgtatc ttaaacagcc     4620

agtggccaga ggctgttggg tcattttccc cactgtccta gcaccgtgtc cctggatctg     4680

ttttcgtggc tccctctgga gtcccgactt gctgggacac cgtggctggg gtaggtgcgg     4740

ctgacggctg tttcccaccc ccag                                            4764


<210>  12
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  12
accccacagu ggggccacua guuuuagagc uaugcuguuu ug                          42


<210>  13
<211>  86
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  13
ggaaccauuc aaaacagcau agcaaguuaa aauaaggcua guccguuauc aacuugaaaa       60

aguggcaccg agucggugcu uuuuuu                                            86


<210>  14
<211>  62
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  14
accccacagu ggggccacua guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cg                                                                      62


<210>  15
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  15
ctgacctctt ctcttcctcc cacag                                             25


<210>  16
<211>  1009
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  16
gccaccatgg actacaaaga cgatgacgac aaggtcgact ctagagctgc agagagcgac       60

gagagcggcc tgcccgccat ggagatcgag tgccgcatca ccggcaccct gaacggcgtg      120

gagttcgagc tggtgggcgg cggagagggc acccccgagc agggccgcat gaccaacaag      180

atgaagagca ccaaaggcgc cctgaccttc agcccctacc tgctgagcca cgtgatgggc      240

tacggcttct accacttcgg cacctacccc agcggctacg agaacccctt cctgcacgcc      300

atcaacaacg gcggctacac caacacccgc atcgagaagt acgaggacgg cggcgtgctg      360

cacgtgagct tcagctaccg ctacgaggcc ggccgcgtga tcggcgactt caaggtgatg      420

ggcaccggct tccccgagga cagcgtgatc ttcaccgaca agatcgtccg cagcaacgcc      480

accgtggagc acctgcaccc catgggcgat aacgatctgg atggcagctt cacccgcacc      540

ttcagcctgc gcgacggcgg ctactacagc tccgtggtgg acagccacat gcacttcaag      600

agcgccatcc accccagcat cctgcagaac gggggcccca tgttcgcctt ccgccgcgtg      660

gaggaggatc acagcaacac cgagctgggc atcgtggagt accagcacgc cttcaagacc      720

ccggatgcag atgccggtga agaatgaaga tctctgtgcc ttctagttgc cagccatctg      780

ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt      840

cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg      900

gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg      960

atgcggtggg ctctatggac tcgaggttta aacgtcgacg cggccgcgt                 1009


<210>  17
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  17

Met Ser Gly Glu Asp Gly Pro Ala Ala Gly Pro Gly Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Arg Glu Arg Arg Arg Glu Gln Leu Arg Gln Trp Gly Ala Arg 
            20                  25                  30          


Ala Gly Ala Glu Pro Gly Pro Gly Glu Arg Arg Ala Arg Thr Val Arg 
        35                  40                  45              


Phe Glu Arg Ala Ala Glu Phe Leu Ala Ala Cys Ala Gly Gly Asp Leu 
    50                  55                  60                  


Asp Glu Ala Arg Leu Met Leu Arg Ala Ala Asp Pro Gly Pro Gly Ala 
65                  70                  75                  80  


Glu Leu Asp Pro Ala Ala Pro Pro Pro Ala Arg Ala Val Leu Asp Ser 
                85                  90                  95      


Thr Asn Ala Asp Gly Ile Ser Ala Leu His Gln Ala Thr Met Asp Tyr 
            100                 105                 110         


Lys Asp Asp Asp Asp Lys Val Asp Ser Arg Ala Ala Glu Ser Asp Glu 
        115                 120                 125             


Ser Gly Leu Pro Ala Met Glu Ile Glu Cys Arg Ile Thr Gly Thr Leu 
    130                 135                 140                 


Asn Gly Val Glu Phe Glu Leu Val Gly Gly Gly Glu Gly Thr Pro Glu 
145                 150                 155                 160 


Gln Gly Arg Met Thr Asn Lys Met Lys Ser Thr Lys Gly Ala Leu Thr 
                165                 170                 175     


Phe Ser Pro Tyr Leu Leu Ser His Val Met Gly Tyr Gly Phe Tyr His 
            180                 185                 190         


Phe Gly Thr Tyr Pro Ser Gly Tyr Glu Asn Pro Phe Leu His Ala Ile 
        195                 200                 205             


Asn Asn Gly Gly Tyr Thr Asn Thr Arg Ile Glu Lys Tyr Glu Asp Gly 
    210                 215                 220                 


Gly Val Leu His Val Ser Phe Ser Tyr Arg Tyr Glu Ala Gly Arg Val 
225                 230                 235                 240 


Ile Gly Asp Phe Lys Val Met Gly Thr Gly Phe Pro Glu Asp Ser Val 
                245                 250                 255     


Ile Phe Thr Asp Lys Ile Val Arg Ser Asn Ala Thr Val Glu His Leu 
            260                 265                 270         


His Pro Met Gly Asp Asn Asp Leu Asp Gly Ser Phe Thr Arg Thr Phe 
        275                 280                 285             


Ser Leu Arg Asp Gly Gly Tyr Tyr Ser Ser Val Val Asp Ser His Met 
    290                 295                 300                 


His Phe Lys Ser Ala Ile His Pro Ser Ile Leu Gln Asn Gly Gly Pro 
305                 310                 315                 320 


Met Phe Ala Phe Arg Arg Val Glu Glu Asp His Ser Asn Thr Glu Leu 
                325                 330                 335     


Gly Ile Val Glu Tyr Gln His Ala Phe Lys Thr Pro Asp Ala Asp Ala 
            340                 345                 350         


Gly Glu Glu 
        355 


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  18
ccactctgtg ctgaccactc t                                                 21


<210>  19
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  19
gcggcactcg atctcca                                                      17


<210>  20
<211>  711
<212>  DNA
<213>  Mus musculus

<400>  20
gagcggctgc ggggcgggtg caagcacgtt tccgacttga gttgcctcaa gaggggcgtg       60

ctgagccaga cctccatcgc gcactccggg gagtggaggg aaggagcgag ggctcagttg      120

ggctgttttg gaggcaggaa gcacttgctc tcccaaagtc gctctgagtt gttatcagta      180

agggagctgc agtggagtag gcggggagaa ggccgcaccc ttctccggag gggggagggg      240

agtgttgcaa tacctttctg ggagttctct gctgcctcct ggcttctgag gaccgccctg      300

ggcctgggag aatcccttcc ccctcttccc tcgtgatctg caactccagt ctttctagaa      360

gatgggcggg agtcttctgg gcaggcttaa aggctaacct ggtgtgtggg cgttgtcctg      420

caggggaatt gaacaggtgt aaaattggag ggacaagact tcccacagat tttcggtttt      480

gtcgggaagt tttttaatag gggcaaataa ggaaaatggg aggataggta gtcatctggg      540

gttttatgca gcaaaactac aggttattat tgcttgtgat ccgcctcgga gtattttcca      600

tcgaggtaga ttaaagacat gctcacccga gttttatact ctcctgcttg agatccttac      660

tacagtatga aattacagtg tcgcgagtta gactatgtaa gcagaatttt a               711


<210>  21
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  21
cuccagucuu ucuagaagau guuuuagagc uaugcuguuu ug                          42


<210>  22
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  22
ugaacaggug uaaaauugga guuuuagagc uaugcuguuu ug                          42


<210>  23
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  23
ugucgggaag uuuuuuaaua guuuuagagc uaugcuguuu ug                          42


<210>  24
<211>  642
<212>  DNA
<213>  Rattus rattus

<400>  24
gggattcctc cttgagttgt ggcactgagg aacgtgctga acaagaccta cattgcactc       60

cagggagtgg atgaaggagt tggggctcag tcgggttgta ttggagacaa gaagcacttg      120

ctctccaaaa gtcggtttga gttatcatta agggagctgc agtggagtag gcggagaaaa      180

ggccgcaccc ttctcaggac gggggagggg agtgttgcaa tacctttctg ggagttctct      240

gctgcctcct gtcttctgag gaccgccctg ggcctggaag attcccttcc cccttcttcc      300

ctcgtgatct gcaactggag tctttctgga agataggcgg gagtcttctg ggcaggctta      360

aaggctaacc tggtgcgtgg ggcgttgtcc tgcagaggaa ttgaacaggt gtaaaattgg      420

aggggcaaga cttcccacag attttcgatt gtgttgttaa gtattgtaat aggggcaaat      480

aagggaaata gactaggcac tcacctgggg ttttatgcag caaaactaca ggttattatt      540

gcttgtgatc cgccctggag aatttttcac cgaggtagat tgaagacatg cccacccaaa      600

ttttaatatt cttccacttg cgatccttgc tacagtatga aa                         642


<210>  25
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  25
agggggaagg gaaucuucca guuuuagagc uaugcuguuu ug                          42


<210>  26
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  26
ucugcaacug gagucuuucu guuuuagagc uaugcuguuu ug                          42


<210>  27
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  27
aggcgggagu cuucugggca guuuuagagc uaugcuguuu ug                          42


