                               SEQUENCE LISTING

<110> ELEVEN BIOTHERAPEUTICS
 
<120> GALECTIN-3 FUSION PROTEINS

<130> D2046-7046WO

<140>
<141>

<150> 61/819,047
<151> 2013-05-03

<150> 61/733,642
<151> 2012-12-05

<160> 25    

<170> PatentIn version 3.5

<210> 1
<211> 250
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn 
1               5                   10                  15      


Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly 
            20                  25                  30          


Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln 
        35                  40                  45              


Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro 
    50                  55                  60                  


Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro 
65                  70                  75                  80  


Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser 
                85                  90                  95      


Ala Thr Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly 
            100                 105                 110         


Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro 
        115                 120                 125             


Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg 
    130                 135                 140                 


Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn 
145                 150                 155                 160 


Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys 
                165                 170                 175     


Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe 
            180                 185                 190         


Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His 
        195                 200                 205             


Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg 
    210                 215                 220                 


Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile 
225                 230                 235                 240 


Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile 
                245                 250 


<210> 2
<211> 142
<212> PRT
<213> Homo sapiens

<400> 2
Gly Ala Pro Ala Gly Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro 
1               5                   10                  15      


Gly Gly Val Val Pro Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys 
            20                  25                  30          


Pro Asn Ala Asn Arg Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val 
        35                  40                  45              


Ala Phe His Phe Asn Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile 
    50                  55                  60                  


Val Cys Asn Thr Lys Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln 
65                  70                  75                  80  


Ser Val Phe Pro Phe Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu 
                85                  90                  95      


Val Glu Pro Asp His Phe Lys Val Ala Val Asn Asp Ala His Leu Leu 
            100                 105                 110         


Gln Tyr Asn His Arg Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly 
        115                 120                 125             


Ile Ser Gly Asp Ile Asp Leu Thr Ser Ala Ser Tyr Thr Met 
    130                 135                 140         


<210> 3
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      consensus sequence"


<220>
<221> VARIANT
<222> (2)..(2) 
<223> /replace="Glu" or "Lys"

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Any amino acid

<220>
<221> VARIANT
<222> (4)..(4) 
<223> /replace="Gln"

<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Any amino acid

<220>
<221> VARIANT
<222> (6)..(6) 
<223> /replace="Arg" or "Glu"

<220>
<221> MOD_RES
<222> (7)..(12) 
<223> Any amino acid

<220>
<221> VARIANT
<222> (10)..(12) 
<223> /replace=" "

<220>
<221> MISC_FEATURE
<222> (7)..(12) 
<223> /note="This region may encompass 3 to 6 residues wherein some
      positions may be absent"

<220>
<221> VARIANT
<222> (13)..(13) 
<223> /replace="Cys" or "Thr" or "Phe"

<220>
<221> VARIANT
<222> (14)..(14) 
<223> /replace="Ile" or "Val" or "Met" or "Phe"

<220>
<221> VARIANT
<222> (15)..(15) 
<223> /replace="Gln" or "Glu" or "Gly" or "Ser" or "Lys" or "Val"

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> Any amino acid

<220>
<221> VARIANT
<222> (17)..(17) 
<223> /replace="His"

<220>
<221> MOD_RES
<222> (18)..(20) 
<223> Any amino acid

<220>
<221> VARIANT
<222> (21)..(21) 
<223> /replace="Glu" or "Asn" or "Lys" or "His" or "Ser" 

<220>
<221> VARIANT
<222> (22)..(22) 
<223> /replace="Ile" or "Val" or "Met" or "Phe" or "Cys" 

<220>
<221> MISC_FEATURE
<222> (1)..(22)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations for 
      variant positions"

<400> 3
Trp Gly Xaa Glu Xaa Lys Xaa Xaa Xaa Xaa Xaa Xaa Pro Leu Asn Xaa 
1               5                   10                  15      


Gly Xaa Xaa Xaa Asp Leu
            20              


<210> 4
<211> 139
<212> PRT
<213> Homo sapiens

<400> 4
Gly Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val 
1               5                   10                  15      


Pro Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn 
            20                  25                  30          


Arg Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe 
        35                  40                  45              


Asn Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr 
    50                  55                  60                  


Lys Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro 
65                  70                  75                  80  


Phe Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp 
                85                  90                  95      


His Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His 
            100                 105                 110         


Arg Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp 
        115                 120                 125             


Ile Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile 
    130                 135                 


<210> 5
<211> 185
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala Lys Pro Thr Glu Asn Asn Glu Asp Phe Asn Ile Val Ala Val Ala 
            20                  25                  30          


Ser Asn Phe Ala Thr Thr Asp Leu Asp Ala Asp Arg Gly Lys Leu Pro 
        35                  40                  45              


Gly Lys Lys Leu Pro Leu Glu Val Leu Lys Glu Met Glu Ala Asn Ala 
    50                  55                  60                  


Arg Lys Ala Gly Cys Thr Arg Gly Cys Leu Ile Cys Leu Ser His Ile 
65                  70                  75                  80  


Lys Cys Thr Pro Lys Met Lys Lys Phe Ile Pro Gly Arg Cys His Thr 
                85                  90                  95      


Tyr Glu Gly Asp Lys Glu Ser Ala Gln Gly Gly Ile Gly Glu Ala Ile 
            100                 105                 110         


Val Asp Ile Pro Glu Ile Pro Gly Phe Lys Asp Leu Glu Pro Met Glu 
        115                 120                 125             


Gln Phe Ile Ala Gln Val Asp Leu Cys Val Asp Cys Thr Thr Gly Cys 
    130                 135                 140                 


Leu Lys Gly Leu Ala Asn Val Gln Cys Ser Asp Leu Leu Lys Lys Trp 
145                 150                 155                 160 


Leu Pro Gln Arg Cys Ala Thr Phe Ala Ser Lys Ile Gln Gly Gln Val 
                165                 170                 175     


Asp Lys Ile Lys Gly Ala Gly Gly Asp 
            180                 185 


<210> 6
<211> 153
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Ala Pro Val Arg Ser Leu Asn Cys Arg Ile Trp Asp Val Asn Gln Lys 
1               5                   10                  15      


Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly 
            20                  25                  30          


Pro Asn Val Asn Leu Glu Glu Lys Phe Ser Met Ser Phe Val Gln Gly 
        35                  40                  45              


Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu Lys 
    50                  55                  60                  


Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr Leu Gln 
65                  70                  75                  80  


Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu Lys 
                85                  90                  95      


Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu Phe Glu 
            100                 105                 110         


Ser Ala Gln Phe Pro Asn Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Tyr Met Gln Phe Val Ser Ser 
145                 150             


<210> 7
<211> 10
<212> PRT
<213> Human immunodeficiency virus

<400> 7
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10  


<210> 8
<211> 465
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Met Ala Pro Val Arg Ser Leu Asn Cys Arg Ile Trp Asp Val Asn Gln 
1               5                   10                  15      


Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln 
            20                  25                  30          


Gly Pro Asn Val Asn Leu Glu Glu Lys Phe Ser Met Ser Phe Val Gln 
        35                  40                  45              


Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu 
    50                  55                  60                  


Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu 
                85                  90                  95      


Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu Phe 
            100                 105                 110         


Glu Ser Ala Gln Phe Pro Asn Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             


Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 


Thr Lys Phe Tyr Met Gln Phe Val Ser Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Arg Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro 
                165                 170                 175     


Gly Gly Val Val Pro Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys 
            180                 185                 190         


Pro Asn Ala Asn Arg Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val 
        195                 200                 205             


Ala Phe His Phe Asn Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile 
    210                 215                 220                 


Val Cys Asn Thr Lys Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln 
225                 230                 235                 240 


Ser Val Phe Pro Phe Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu 
                245                 250                 255     


Val Glu Pro Asp His Phe Lys Val Ala Val Asn Asp Ala His Leu Leu 
            260                 265                 270         


Gln Tyr Asn His Arg Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly 
        275                 280                 285             


Ile Ser Gly Asp Ile Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Leu 
305                 310                 315                 320 


Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro Arg Met 
                325                 330                 335     


Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg Ile Ala 
            340                 345                 350         


Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn Pro Arg 
        355                 360                 365             


Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys Leu Asp 
    370                 375                 380                 


Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe Glu Ser 
385                 390                 395                 400 


Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His Phe Lys 
                405                 410                 415     


Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg Val Lys 
            420                 425                 430         


Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile Asp Leu 
        435                 440                 445             


Thr Ser Ala Ser Tyr Thr Met Ile Ser His His His His His His His 
    450                 455                 460                 


His 
465 


<210> 9
<211> 233
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 9
Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Val Leu Ile Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser 
            100                 105                 110         


Thr Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu 
225                 230             


<210> 10
<211> 558
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 10
Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asp Phe 
        35                  40                  45              


Thr His Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala 
65                  70                  75                  80  


Ala Asp Phe Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Gly Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ala Ala Ala 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro 
            260                 265                 270         


Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg 
        275                 280                 285             


Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn 
    290                 295                 300                 


Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys 
305                 310                 315                 320 


Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe 
                325                 330                 335     


Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His 
            340                 345                 350         


Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg 
        355                 360                 365             


Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile 
    370                 375                 380                 


Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile Ser Ser Gly Gly Asp Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro Leu Ile Val Pro Tyr 
                405                 410                 415     


Asn Leu Pro Leu Pro Gly Gly Val Val Pro Arg Met Leu Ile Thr Ile 
            420                 425                 430         


Leu Gly Thr Val Lys Pro Asn Ala Asn Arg Ile Ala Leu Asp Phe Gln 
        435                 440                 445             


Arg Gly Asn Asp Val Ala Phe His Phe Asn Pro Arg Phe Asn Glu Asn 
    450                 455                 460                 


Asn Arg Arg Val Ile Val Cys Asn Thr Lys Leu Asp Asn Asn Trp Gly 
465                 470                 475                 480 


Arg Glu Glu Arg Gln Ser Val Phe Pro Phe Glu Ser Gly Lys Pro Phe 
                485                 490                 495     


Lys Ile Gln Val Leu Val Glu Pro Asp His Phe Lys Val Ala Val Asn 
            500                 505                 510         


Asp Ala His Leu Leu Gln Tyr Asn His Arg Val Lys Lys Leu Asn Glu 
        515                 520                 525             


Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile Asp Leu Thr Ser Ala Ser 
    530                 535                 540                 


Tyr Thr Met Ile Ser Arg His His His His His His His His 
545                 550                 555             


<210> 11
<211> 238
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 11
Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Asn Tyr Gly Ile Pro Phe Met Asn Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Arg Gly Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Ser Glu Glu Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210> 12
<211> 565
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 12
Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Leu 
        35                  40                  45              


Ser Asn Tyr Leu Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Val Ile Thr Pro Gly Ser Gly Thr Ile Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Arg Trp Asp Pro Leu Tyr Tyr Tyr Ala Leu 
        115                 120                 125             


Glu Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Pro Leu Ile Val Pro Tyr Asn Leu Pro 
            260                 265                 270         


Leu Pro Gly Gly Val Val Pro Arg Met Leu Ile Thr Ile Leu Gly Thr 
        275                 280                 285             


Val Lys Pro Asn Ala Asn Arg Ile Ala Leu Asp Phe Gln Arg Gly Asn 
    290                 295                 300                 


Asp Val Ala Phe His Phe Asn Pro Arg Phe Asn Glu Asn Asn Arg Arg 
305                 310                 315                 320 


Val Ile Val Cys Asn Thr Lys Leu Asp Asn Asn Trp Gly Arg Glu Glu 
                325                 330                 335     


Arg Gln Ser Val Phe Pro Phe Glu Ser Gly Lys Pro Phe Lys Ile Gln 
            340                 345                 350         


Val Leu Val Glu Pro Asp His Phe Lys Val Ala Val Asn Asp Ala His 
        355                 360                 365             


Leu Leu Gln Tyr Asn His Arg Val Lys Lys Leu Asn Glu Ile Ser Lys 
    370                 375                 380                 


Leu Gly Ile Ser Gly Asp Ile Asp Leu Thr Ser Ala Ser Tyr Thr Met 
385                 390                 395                 400 


Ile Ser Ser Gly Gly Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                405                 410                 415     


Gly Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val 
            420                 425                 430         


Pro Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn 
        435                 440                 445             


Arg Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe 
    450                 455                 460                 


Asn Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr 
465                 470                 475                 480 


Lys Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro 
                485                 490                 495     


Phe Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp 
            500                 505                 510         


His Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His 
        515                 520                 525             


Arg Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp 
    530                 535                 540                 


Ile Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile Ser Arg His His His 
545                 550                 555                 560 


His His His His His 
                565 


<210> 13
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      8xHis tag"

<400> 13
His His His His His His His His 
1               5               


<210> 14
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 14
Gly Gly Gly Gly Ser 
1               5   


<210> 15
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 15
Glu Ala Ala Ala Lys 
1               5   


<210> 16
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 16
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 17
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 17
His His His His His His 
1               5       


<210> 18
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 18
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 19
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 19
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 20
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 20
Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
1               5                   10                  15      


Ala Ala Ala Lys 
            20  


<210> 21
<211> 452
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 21
Met Ala Pro Val Arg Ser Leu Asn Cys Arg Ile Trp Asp Val Asn Gln 
1               5                   10                  15      


Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln 
            20                  25                  30          


Gly Pro Asn Val Asn Leu Glu Glu Lys Phe Ser Met Ser Phe Val Gln 
        35                  40                  45              


Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu 
    50                  55                  60                  


Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu 
                85                  90                  95      


Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu Phe 
            100                 105                 110         


Glu Ser Ala Gln Phe Pro Asn Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             


Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 


Thr Lys Phe Tyr Met Gln Phe Val Ser Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Arg Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro 
                165                 170                 175     


Gly Gly Val Val Pro Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys 
            180                 185                 190         


Pro Asn Ala Asn Arg Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val 
        195                 200                 205             


Ala Phe His Phe Asn Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile 
    210                 215                 220                 


Val Cys Asn Thr Lys Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln 
225                 230                 235                 240 


Ser Val Phe Pro Phe Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu 
                245                 250                 255     


Val Glu Pro Asp His Phe Lys Val Ala Val Asn Asp Ala His Leu Leu 
            260                 265                 270         


Gln Tyr Asn His Arg Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly 
        275                 280                 285             


Ile Ser Gly Asp Ile Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile Gly 
    290                 295                 300                 


Ser Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val 
305                 310                 315                 320 


Pro Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn 
                325                 330                 335     


Arg Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe 
            340                 345                 350         


Asn Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr 
        355                 360                 365             


Lys Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro 
    370                 375                 380                 


Phe Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp 
385                 390                 395                 400 


His Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His 
                405                 410                 415     


Arg Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp 
            420                 425                 430         


Ile Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile Ser His His His His 
        435                 440                 445             


His His His His 
    450         


<210> 22
<211> 455
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 22
Met Ala Pro Val Arg Ser Leu Asn Cys Arg Ile Trp Asp Val Asn Gln 
1               5                   10                  15      


Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln 
            20                  25                  30          


Gly Pro Asn Val Asn Leu Glu Glu Lys Phe Ser Met Ser Phe Val Gln 
        35                  40                  45              


Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu 
    50                  55                  60                  


Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu 
                85                  90                  95      


Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu Phe 
            100                 105                 110         


Glu Ser Ala Gln Phe Pro Asn Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             


Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 


Thr Lys Phe Tyr Met Gln Phe Val Ser Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Arg Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro 
                165                 170                 175     


Gly Gly Val Val Pro Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys 
            180                 185                 190         


Pro Asn Ala Asn Arg Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val 
        195                 200                 205             


Ala Phe His Phe Asn Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile 
    210                 215                 220                 


Val Cys Asn Thr Lys Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln 
225                 230                 235                 240 


Ser Val Phe Pro Phe Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu 
                245                 250                 255     


Val Glu Pro Asp His Phe Lys Val Ala Val Asn Asp Ala His Leu Leu 
            260                 265                 270         


Gln Tyr Asn His Arg Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly 
        275                 280                 285             


Ile Ser Gly Asp Ile Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile Gly 
    290                 295                 300                 


Gly Gly Gly Ser Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly 
305                 310                 315                 320 


Gly Val Val Pro Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro 
                325                 330                 335     


Asn Ala Asn Arg Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala 
            340                 345                 350         


Phe His Phe Asn Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val 
        355                 360                 365             


Cys Asn Thr Lys Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser 
    370                 375                 380                 


Val Phe Pro Phe Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val 
385                 390                 395                 400 


Glu Pro Asp His Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln 
                405                 410                 415     


Tyr Asn His Arg Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile 
            420                 425                 430         


Ser Gly Asp Ile Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile Ser His 
        435                 440                 445             


His His His His His His His 
    450                 455 


<210> 23
<211> 460
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 23
Met Ala Pro Val Arg Ser Leu Asn Cys Arg Ile Trp Asp Val Asn Gln 
1               5                   10                  15      


Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln 
            20                  25                  30          


Gly Pro Asn Val Asn Leu Glu Glu Lys Phe Ser Met Ser Phe Val Gln 
        35                  40                  45              


Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu 
    50                  55                  60                  


Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu 
                85                  90                  95      


Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu Phe 
            100                 105                 110         


Glu Ser Ala Gln Phe Pro Asn Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             


Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 


Thr Lys Phe Tyr Met Gln Phe Val Ser Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Arg Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro 
                165                 170                 175     


Gly Gly Val Val Pro Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys 
            180                 185                 190         


Pro Asn Ala Asn Arg Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val 
        195                 200                 205             


Ala Phe His Phe Asn Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile 
    210                 215                 220                 


Val Cys Asn Thr Lys Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln 
225                 230                 235                 240 


Ser Val Phe Pro Phe Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu 
                245                 250                 255     


Val Glu Pro Asp His Phe Lys Val Ala Val Asn Asp Ala His Leu Leu 
            260                 265                 270         


Gln Tyr Asn His Arg Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly 
        275                 280                 285             


Ile Ser Gly Asp Ile Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Leu Ile Val Pro Tyr Asn 
305                 310                 315                 320 


Leu Pro Leu Pro Gly Gly Val Val Pro Arg Met Leu Ile Thr Ile Leu 
                325                 330                 335     


Gly Thr Val Lys Pro Asn Ala Asn Arg Ile Ala Leu Asp Phe Gln Arg 
            340                 345                 350         


Gly Asn Asp Val Ala Phe His Phe Asn Pro Arg Phe Asn Glu Asn Asn 
        355                 360                 365             


Arg Arg Val Ile Val Cys Asn Thr Lys Leu Asp Asn Asn Trp Gly Arg 
    370                 375                 380                 


Glu Glu Arg Gln Ser Val Phe Pro Phe Glu Ser Gly Lys Pro Phe Lys 
385                 390                 395                 400 


Ile Gln Val Leu Val Glu Pro Asp His Phe Lys Val Ala Val Asn Asp 
                405                 410                 415     


Ala His Leu Leu Gln Tyr Asn His Arg Val Lys Lys Leu Asn Glu Ile 
            420                 425                 430         


Ser Lys Leu Gly Ile Ser Gly Asp Ile Asp Leu Thr Ser Ala Ser Tyr 
        435                 440                 445             


Thr Met Ile Ser His His His His His His His His 
    450                 455                 460 


<210> 24
<211> 470
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 24
Met Ala Pro Val Arg Ser Leu Asn Cys Arg Ile Trp Asp Val Asn Gln 
1               5                   10                  15      


Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln 
            20                  25                  30          


Gly Pro Asn Val Asn Leu Glu Glu Lys Phe Ser Met Ser Phe Val Gln 
        35                  40                  45              


Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu 
    50                  55                  60                  


Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu 
                85                  90                  95      


Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu Phe 
            100                 105                 110         


Glu Ser Ala Gln Phe Pro Asn Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             


Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 


Thr Lys Phe Tyr Met Gln Phe Val Ser Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Arg Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro 
                165                 170                 175     


Gly Gly Val Val Pro Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys 
            180                 185                 190         


Pro Asn Ala Asn Arg Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val 
        195                 200                 205             


Ala Phe His Phe Asn Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile 
    210                 215                 220                 


Val Cys Asn Thr Lys Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln 
225                 230                 235                 240 


Ser Val Phe Pro Phe Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu 
                245                 250                 255     


Val Glu Pro Asp His Phe Lys Val Ala Val Asn Asp Ala His Leu Leu 
            260                 265                 270         


Gln Tyr Asn His Arg Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly 
        275                 280                 285             


Ile Ser Gly Asp Ile Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly 
                325                 330                 335     


Val Val Pro Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn 
            340                 345                 350         


Ala Asn Arg Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe 
        355                 360                 365             


His Phe Asn Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys 
    370                 375                 380                 


Asn Thr Lys Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val 
385                 390                 395                 400 


Phe Pro Phe Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu 
                405                 410                 415     


Pro Asp His Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr 
            420                 425                 430         


Asn His Arg Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser 
        435                 440                 445             


Gly Asp Ile Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile Ser His His 
    450                 455                 460                 


His His His His His His 
465                 470 


<210> 25
<211> 477
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 25
Met Ala Pro Val Arg Ser Leu Asn Cys Arg Ile Trp Asp Val Asn Gln 
1               5                   10                  15      


Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln 
            20                  25                  30          


Gly Pro Asn Val Asn Leu Glu Glu Lys Phe Ser Met Ser Phe Val Gln 
        35                  40                  45              


Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu 
    50                  55                  60                  


Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu 
                85                  90                  95      


Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu Phe 
            100                 105                 110         


Glu Ser Ala Gln Phe Pro Asn Trp Phe Leu Cys Thr Ala Met Glu Ala 
        115                 120                 125             


Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 
    130                 135                 140                 


Thr Lys Phe Tyr Met Gln Phe Val Ser Ser Ala Glu Ala Ala Ala Lys 
145                 150                 155                 160 


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
                165                 170                 175     


Arg Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val 
            180                 185                 190         


Pro Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn 
        195                 200                 205             


Arg Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe 
    210                 215                 220                 


Asn Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr 
225                 230                 235                 240 


Lys Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro 
                245                 250                 255     


Phe Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp 
            260                 265                 270         


His Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His 
        275                 280                 285             


Arg Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp 
    290                 295                 300                 


Ile Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Leu Ile Val Pro Tyr 
                325                 330                 335     


Asn Leu Pro Leu Pro Gly Gly Val Val Pro Arg Met Leu Ile Thr Ile 
            340                 345                 350         


Leu Gly Thr Val Lys Pro Asn Ala Asn Arg Ile Ala Leu Asp Phe Gln 
        355                 360                 365             


Arg Gly Asn Asp Val Ala Phe His Phe Asn Pro Arg Phe Asn Glu Asn 
    370                 375                 380                 


Asn Arg Arg Val Ile Val Cys Asn Thr Lys Leu Asp Asn Asn Trp Gly 
385                 390                 395                 400 


Arg Glu Glu Arg Gln Ser Val Phe Pro Phe Glu Ser Gly Lys Pro Phe 
                405                 410                 415     


Lys Ile Gln Val Leu Val Glu Pro Asp His Phe Lys Val Ala Val Asn 
            420                 425                 430         


Asp Ala His Leu Leu Gln Tyr Asn His Arg Val Lys Lys Leu Asn Glu 
        435                 440                 445             


Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile Asp Leu Thr Ser Ala Ser 
    450                 455                 460                 


Tyr Thr Met Ile Ser His His His His His His His His 
465                 470                 475         


