                               SEQUENCE LISTING

<110> AVEO PHARMACEUTICALS, INC.
 
<120> ANTI-FGFR2 ANTIBODIES

<130> AVO-027PC

<140>
<141>

<150> 61/733,285
<151> 2012-12-04

<160> 60    

<170> PatentIn version 3.5

<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1
Trp Tyr Trp Met Glu 
1               5   


<210> 2
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 2
Trp Phe Trp Met Glu 
1               5   


<210> 3
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 3
Trp Asn Trp Met Gln 
1               5   


<210> 4
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 4
Tyr Ile Gly Pro Ser Gly Gly Val Thr Gln Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 5
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 5
Tyr Ile Ser Pro Ser Gly Gly Tyr Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 6
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 6
Asp Gly Ala Ala Ala Phe Asp Tyr 
1               5               


<210> 7
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 7
Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210> 8
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 8
Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Phe Leu 
1               5                   10                  15      


Ala 
    


<210> 9
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 9
Trp Ala Ser Ile Arg Glu Ser 
1               5           


<210> 10
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 10
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 11
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 11
Gln Gln Tyr Tyr Ala Ile Pro Tyr Thr 
1               5                   


<210> 12
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 12
Leu Gln Tyr His Ala Ile Pro Tyr Thr 
1               5                   


<210> 13
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 13
Gln Gln Phe Phe Ser Thr Pro Phe Thr 
1               5                   


<210> 14
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 14
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Tyr 
            20                  25                  30          


Trp Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Gly Pro Ser Gly Gly Val Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ala Ala Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 15
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 15
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct tggtactgga tggagtgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttcttat atcggtcctt ctggtggcgt tactcagtat      180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagatgga      300

gcagcagcct ttgactactg gggccaggga accctggtca ccgtctcaag c               351


<210> 16
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Phe 
            20                  25                  30          


Trp Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Gly Pro Ser Gly Gly Val Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ala Ala Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 17
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 17
gaggtacagc tccttgagtc aggcggaggt ttggtccaac cgggaggttc gctgcggctt       60

agctgtgcgg cgtcagggtt caccttctcc tggtactgga tggaatgggt acgacaggct      120

cccggaaaag gacttgaatg ggtgtcatac atcgggccat ccgggggagt cacgcaatac      180

gccgactccg tgaaggggag attcacgatc tcaagggaca actcgaagaa taccctctat      240

cttcagatga actcccttcg agcggaagat acagcggtgt attactgtgc ccgcgatggt      300

gctgccgcgt ttgactattg gggacagggg acgcttgtaa cagtgtcatc a               351


<210> 18
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 18
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Asn 
            20                  25                  30          


Trp Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Pro Ser Gly Gly Tyr Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ala Ala Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 19
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 19
gaggtacagc tccttgagtc aggcggaggt ttggtccaac cgggaggttc gctgcggctt       60

agctgtgcgg cgtcagggtt caccttctcc tggttctgga tggaatgggt acgacaggct      120

cccggaaaag gacttgaatg ggtgtcatac atcgggccat ccgggggagt cacgcaatac      180

gccgactccg tgaaggggag attcacgatc tcaagggaca actcgaagaa taccctctat      240

cttcagatga actcccttcg agcggaagat acagcggtgt attactgtgc ccgcgatggt      300

gctgccgcgt ttgactattg gggacagggg acgcttgtaa cagtgtcatc a               351


<210> 20
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 20
Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Ala Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Ser Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Leu Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ala Ile Pro Tyr Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210> 21
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 21
gaggtacagc tccttgagtc aggcggaggt ttggtccaac cgggaggttc gctgcggctt       60

agctgtgcgg cgtcagggtt caccttctcc tggaactgga tgcagtgggt acgacaggct      120

cccggaaaag gacttgaatg ggtgtcatac atctcgccat ccgggggata cacggtgtac      180

gccgactccg tgaaggggag attcacgatc tcaagggaca actcgaagaa taccctctat      240

cttcagatga actcccttcg agcggaagat acagcggtgt attactgtgc ccgcgatggt      300

gctgccgcgt ttgactattg gggacagggg acgcttgtaa cagtgtcatc a               351


<210> 22
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 22
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Ser Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ala Ile Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210> 23
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 23
gacatccaga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ctacttaact      120

tggtaccagc agaaagcagg acagcctcct aagttgctca tttcgtgggc atctattcgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca ctttattact gtcagcaata ttatgctatt      300

ccgtacactt ttggccaggg gaccaggctg gagatcaaa                             339


<210> 24
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 24
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Ser Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Leu Gln 
                85                  90                  95      


Tyr His Ala Ile Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210> 25
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 25
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ctacttaact      120

tggtaccagc agaaacccgg acagcctcct aagttgctca tttcgtgggc atctattcgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtctattact gtcagcaata ttatgctatt      300

ccgtacactt ttggccaggg gaccaagctg gagatcaaa                             339


<210> 26
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 26
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Ser Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Phe Phe Ser Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile 
            100                 105                 110         


Lys 
    


<210> 27
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 27
gacattgtga tgacgcagtc accggattca ctggcagtgt cgctgggaga aagagcgacc       60

atcaattgca agagcagcca atcagtgttg tactcatcga acaataagaa ctatctcaca      120

tggtatcaac agaaacccgg tcagcctccg aaattgctta tttcgtgggc gtccatccgc      180

gagtcaggcg tcccagacag gttttcgggg tcgggttcgg ggacagattt cactttgaca      240

atcagctcac tgcaggcgga ggacgtggcg gtctactact gcttgcaata tcacgcaatt      300

ccctatactt ttgggcaggg aactaagttg gaaatcaag                             339


<210> 28
<211> 330
<212> PRT
<213> Homo sapiens

<400> 28
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210> 29
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 29
gacattgtga tgacgcagtc accggattca ctggcagtgt cgctgggaga aagagcgacc       60

atcaattgca agagcagcca atcagtgttg tactcatcga acaataagaa cttcctcgcg      120

tggtatcaac agaaacccgg tcagcctccg aaattgctta tttcgtgggc gtccacgcgc      180

gagtcaggcg tcccagacag gttttcgggg tcgggttcgg ggacagattt cactttgaca      240

atcagctcac tgcaggcgga ggacgtggcg gtctactact gccagcaatt cttttccacg      300

cccttcactt ttgggccggg aactaaggtg gatatcaag                             339


<210> 30
<211> 107
<212> PRT
<213> Homo sapiens

<400> 30
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210> 31
<211> 990
<212> DNA
<213> Homo sapiens

<400> 31
gcctcaacaa aaggaccaag tgtgttccca ctcgccccta gcagcaagag tacatccggg       60

ggcactgcag cactcggctg cctcgtcaag gattattttc cagagccagt aaccgtgagc      120

tggaacagtg gagcactcac ttctggtgtc catacttttc ctgctgtcct gcaaagctct      180

ggcctgtact cactcagctc cgtcgtgacc gtgccatctt catctctggg cactcagacc      240

tacatctgta atgtaaacca caagcctagc aatactaagg tcgataagcg ggtggaaccc      300

aagagctgcg acaagactca cacttgtccc ccatgccctg cccctgaact tctgggcggt      360

cccagcgtct ttttgttccc accaaagcct aaagatactc tgatgataag tagaacaccc      420

gaggtgacat gtgttgttgt agacgtttcc cacgaggacc cagaggttaa gttcaactgg      480

tacgttgatg gagtcgaagt acataatgct aagaccaagc ctagagagga gcagtataat      540

agtacatacc gtgtagtcag tgttctcaca gtgctgcacc aagactggct caacggcaaa      600

gaatacaaat gcaaagtgtc caacaaagca ctcccagccc ctatcgagaa gactattagt      660

aaggcaaagg ggcagcctcg tgaaccacag gtgtacactc tgccacccag tagagaggaa      720

atgacaaaga accaagtctc attgacctgc ctggtgaaag gcttctaccc cagcgacatc      780

gccgttgagt gggagagtaa cggtcagcct gagaacaatt acaagacaac ccccccagtg      840

ctggatagtg acgggtcttt ctttctgtac agtaagctga ctgtggacaa gtcccgctgg      900

cagcagggta acgtcttcag ctgttccgtg atgcacgagg cattgcacaa ccactacacc      960

cagaagtcac tgagcctgag cccagggaag                                       990


<210> 32
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 32
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Tyr 
            20                  25                  30          


Trp Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Gly Pro Ser Gly Gly Val Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ala Ala Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210> 33
<211> 321
<212> DNA
<213> Homo sapiens

<400> 33
cgcacagtcg ccgctccctc cgtgttcatc tttccaccaa gtgatgagca actgaagtct       60

ggtactgctt cagtcgtgtg tctgctgaac aatttctacc ctcgagaagc caaagtccaa      120

tggaaggtag acaacgcact gcagtccggc aatagccaag aatcagttac cgaacaggat      180

tcaaaggaca gtacatattc cctgagcagc actctgaccc tgtcaaaggc cgattacgag      240

aaacacaagg tctatgcttg cgaagtgaca catcagggac tgtccagccc agtgacaaaa      300

tcttttaacc gtggggagtg t                                                321


<210> 34
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 34
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Phe 
            20                  25                  30          


Trp Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Gly Pro Ser Gly Gly Val Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ala Ala Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210> 35
<211> 1341
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 35
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct tggtactgga tggagtgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttcttat atcggtcctt ctggtggcgt tactcagtat      180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagatgga      300

gcagcagcct ttgactactg gggccaggga accctggtca ccgtctcaag cgcctcaaca      360

aaaggaccaa gtgtgttccc actcgcccct agcagcaaga gtacatccgg gggcactgca      420

gcactcggct gcctcgtcaa ggattatttt ccagagccag taaccgtgag ctggaacagt      480

ggagcactca cttctggtgt ccatactttt cctgctgtcc tgcaaagctc tggcctgtac      540

tcactcagct ccgtcgtgac cgtgccatct tcatctctgg gcactcagac ctacatctgt      600

aatgtaaacc acaagcctag caatactaag gtcgataagc gggtggaacc caagagctgc      660

gacaagactc acacttgtcc cccatgccct gcccctgaac ttctgggcgg tcccagcgtc      720

tttttgttcc caccaaagcc taaagatact ctgatgataa gtagaacacc cgaggtgaca      780

tgtgttgttg tagacgtttc ccacgaggac ccagaggtta agttcaactg gtacgttgat      840

ggagtcgaag tacataatgc taagaccaag cctagagagg agcagtataa tagtacatac      900

cgtgtagtca gtgttctcac agtgctgcac caagactggc tcaacggcaa agaatacaaa      960

tgcaaagtgt ccaacaaagc actcccagcc cctatcgaga agactattag taaggcaaag     1020

gggcagcctc gtgaaccaca ggtgtacact ctgccaccca gtagagagga aatgacaaag     1080

aaccaagtct cattgacctg cctggtgaaa ggcttctacc ccagcgacat cgccgttgag     1140

tgggagagta acggtcagcc tgagaacaat tacaagacaa cccccccagt gctggatagt     1200

gacgggtctt tctttctgta cagtaagctg actgtggaca agtcccgctg gcagcagggt     1260

aacgtcttca gctgttccgt gatgcacgag gcattgcaca accactacac ccagaagtca     1320

ctgagcctga gcccagggaa g                                               1341


<210> 36
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 36
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Asn 
            20                  25                  30          


Trp Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Pro Ser Gly Gly Tyr Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ala Ala Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210> 37
<211> 1341
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 37
gaggtacagc tccttgagtc aggcggaggt ttggtccaac cgggaggttc gctgcggctt       60

agctgtgcgg cgtcagggtt caccttctcc tggtactgga tggaatgggt acgacaggct      120

cccggaaaag gacttgaatg ggtgtcatac atcgggccat ccgggggagt cacgcaatac      180

gccgactccg tgaaggggag attcacgatc tcaagggaca actcgaagaa taccctctat      240

cttcagatga actcccttcg agcggaagat acagcggtgt attactgtgc ccgcgatggt      300

gctgccgcgt ttgactattg gggacagggg acgcttgtaa cagtgtcatc agcgtcaaca      360

aaaggaccgt cggtattccc cctggctcct tcctcgaaga gcaccagcgg tggcacggct      420

gcgctgggat gtttggtgaa agattacttc ccggaacccg tgacggtgtc atggaactcg      480

ggggcattga cgtcaggggt gcatacgttt ccggccgtgc tgcagtccag cggactctac      540

tcgctttcat ccgtggtaac tgtgccttcc tcctcattgg gaactcagac atacatctgc      600

aatgtcaacc acaagccctc caacacgaaa gtcgataaac gggtggagcc aaagagctgc      660

gataaaacac acacctgccc gccatgtccg gctcccgagt tgttgggcgg tccctccgtg      720

tttttgttcc ctcccaagcc caaagacacc cttatgatta gcaggacacc ggaggtgacg      780

tgcgtggtgg tagacgtcag ccatgaagat cccgaggtca agtttaactg gtatgtggac      840

ggagtcgaag tacataacgc caaaactaaa cccagagagg agcagtataa ctcgacctac      900

cgcgtggtat cagtcttgac agtgcttcac caggactggc tcaatgggaa ggagtacaag      960

tgcaaggtat ccaataaggc actccccgca ccgattgaaa agaccatctc gaaagcgaag     1020

ggtcagccca gggagccgca agtatatacg ctcccgccgt cccgcgagga aatgaccaag     1080

aatcaggtgt cgctcacatg cctcgtgaaa ggattctacc cctcggatat tgcagtggaa     1140

tgggagtcga acgggcagcc cgagaataac tataagacga caccgcctgt gctggactcc     1200

gacggttcgt ttttcctcta tagcaaattg acggtggata agtcaagatg gcaacaagga     1260

aatgtctttt cgtgctcggt catgcacgag gccctgcata atcactatac gcagaagtcc     1320

ctgagcttgt cgccgggaaa g                                               1341


<210> 38
<211> 220
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 38
Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Ala Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Ser Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Leu Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ala Ile Pro Tyr Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210> 39
<211> 1341
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 39
gaggtacagc tccttgagtc aggcggaggt ttggtccaac cgggaggttc gctgcggctt       60

agctgtgcgg cgtcagggtt caccttctcc tggttctgga tggaatgggt acgacaggct      120

cccggaaaag gacttgaatg ggtgtcatac atcgggccat ccgggggagt cacgcaatac      180

gccgactccg tgaaggggag attcacgatc tcaagggaca actcgaagaa taccctctat      240

cttcagatga actcccttcg agcggaagat acagcggtgt attactgtgc ccgcgatggt      300

gctgccgcgt ttgactattg gggacagggg acgcttgtaa cagtgtcatc agcgtcaaca      360

aaaggaccgt cggtattccc cctggctcct tcctcgaaga gcaccagcgg tggcacggct      420

gcgctgggat gtttggtgaa agattacttc ccggaacccg tgacggtgtc atggaactcg      480

ggggcattga cgtcaggggt gcatacgttt ccggccgtgc tgcagtccag cggactctac      540

tcgctttcat ccgtggtaac tgtgccttcc tcctcattgg gaactcagac atacatctgc      600

aatgtcaacc acaagccctc caacacgaaa gtcgataaac gggtggagcc aaagagctgc      660

gataaaacac acacctgccc gccatgtccg gctcccgagt tgttgggcgg tccctccgtg      720

tttttgttcc ctcccaagcc caaagacacc cttatgatta gcaggacacc ggaggtgacg      780

tgcgtggtgg tagacgtcag ccatgaagat cccgaggtca agtttaactg gtatgtggac      840

ggagtcgaag tacataacgc caaaactaaa cccagagagg agcagtataa ctcgacctac      900

cgcgtggtat cagtcttgac agtgcttcac caggactggc tcaatgggaa ggagtacaag      960

tgcaaggtat ccaataaggc actccccgca ccgattgaaa agaccatctc gaaagcgaag     1020

ggtcagccca gggagccgca agtatatacg ctcccgccgt cccgcgagga aatgaccaag     1080

aatcaggtgt cgctcacatg cctcgtgaaa ggattctacc cctcggatat tgcagtggaa     1140

tgggagtcga acgggcagcc cgagaataac tataagacga caccgcctgt gctggactcc     1200

gacggttcgt ttttcctcta tagcaaattg acggtggata agtcaagatg gcaacaagga     1260

aatgtctttt cgtgctcggt catgcacgag gccctgcata atcactatac gcagaagtcc     1320

ctgagcttgt cgccgggaaa g                                               1341


<210> 40
<211> 220
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 40
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Ser Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ala Ile Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210> 41
<211> 1341
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 41
gaggtacagc tccttgagtc aggcggaggt ttggtccaac cgggaggttc gctgcggctt       60

agctgtgcgg cgtcagggtt caccttctcc tggaactgga tgcagtgggt acgacaggct      120

cccggaaaag gacttgaatg ggtgtcatac atctcgccat ccgggggata cacggtgtac      180

gccgactccg tgaaggggag attcacgatc tcaagggaca actcgaagaa taccctctat      240

cttcagatga actcccttcg agcggaagat acagcggtgt attactgtgc ccgcgatggt      300

gctgccgcgt ttgactattg gggacagggg acgcttgtaa cagtgtcatc agcgtcaaca      360

aaaggaccgt cggtattccc cctggctcct tcctcgaaga gcaccagcgg tggcacggct      420

gcgctgggat gtttggtgaa agattacttc ccggaacccg tgacggtgtc atggaactcg      480

ggggcattga cgtcaggggt gcatacgttt ccggccgtgc tgcagtccag cggactctac      540

tcgctttcat ccgtggtaac tgtgccttcc tcctcattgg gaactcagac atacatctgc      600

aatgtcaacc acaagccctc caacacgaaa gtcgataaac gggtggagcc aaagagctgc      660

gataaaacac acacctgccc gccatgtccg gctcccgagt tgttgggcgg tccctccgtg      720

tttttgttcc ctcccaagcc caaagacacc cttatgatta gcaggacacc ggaggtgacg      780

tgcgtggtgg tagacgtcag ccatgaagat cccgaggtca agtttaactg gtatgtggac      840

ggagtcgaag tacataacgc caaaactaaa cccagagagg agcagtataa ctcgacctac      900

cgcgtggtat cagtcttgac agtgcttcac caggactggc tcaatgggaa ggagtacaag      960

tgcaaggtat ccaataaggc actccccgca ccgattgaaa agaccatctc gaaagcgaag     1020

ggtcagccca gggagccgca agtatatacg ctcccgccgt cccgcgagga aatgaccaag     1080

aatcaggtgt cgctcacatg cctcgtgaaa ggattctacc cctcggatat tgcagtggaa     1140

tgggagtcga acgggcagcc cgagaataac tataagacga caccgcctgt gctggactcc     1200

gacggttcgt ttttcctcta tagcaaattg acggtggata agtcaagatg gcaacaagga     1260

aatgtctttt cgtgctcggt catgcacgag gccctgcata atcactatac gcagaagtcc     1320

ctgagcttgt cgccgggaaa g                                               1341


<210> 42
<211> 220
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 42
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Ser Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Leu Gln 
                85                  90                  95      


Tyr His Ala Ile Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210> 43
<211> 660
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 43
gacatccaga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ctacttaact      120

tggtaccagc agaaagcagg acagcctcct aagttgctca tttcgtgggc atctattcgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca ctttattact gtcagcaata ttatgctatt      300

ccgtacactt ttggccaggg gaccaggctg gagatcaaac gcacagtcgc cgctccctcc      360

gtgttcatct ttccaccaag tgatgagcaa ctgaagtctg gtactgcttc agtcgtgtgt      420

ctgctgaaca atttctaccc tcgagaagcc aaagtccaat ggaaggtaga caacgcactg      480

cagtccggca atagccaaga atcagttacc gaacaggatt caaaggacag tacatattcc      540

ctgagcagca ctctgaccct gtcaaaggcc gattacgaga aacacaaggt ctatgcttgc      600

gaagtgacac atcagggact gtccagccca gtgacaaaat cttttaaccg tggggagtgt      660


<210> 44
<211> 220
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 44
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Ser Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Phe Phe Ser Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210> 45
<211> 660
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 45
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ctacttaact      120

tggtaccagc agaaacccgg acagcctcct aagttgctca tttcgtgggc atctattcgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtctattact gtcagcaata ttatgctatt      300

ccgtacactt ttggccaggg gaccaagctg gagatcaaac gcacagtcgc cgctccctcc      360

gtgttcatct ttccaccaag tgatgagcaa ctgaagtctg gtactgcttc agtcgtgtgt      420

ctgctgaaca atttctaccc tcgagaagcc aaagtccaat ggaaggtaga caacgcactg      480

cagtccggca atagccaaga atcagttacc gaacaggatt caaaggacag tacatattcc      540

ctgagcagca ctctgaccct gtcaaaggcc gattacgaga aacacaaggt ctatgcttgc      600

gaagtgacac atcagggact gtccagccca gtgacaaaat cttttaaccg tggggagtgt      660


<210> 46
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 46
Gly Phe Thr Phe Ser Trp Tyr 
1               5           


<210> 47
<211> 660
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 47
gacattgtga tgacgcagtc accggattca ctggcagtgt cgctgggaga aagagcgacc       60

atcaattgca agagcagcca atcagtgttg tactcatcga acaataagaa ctatctcaca      120

tggtatcaac agaaacccgg tcagcctccg aaattgctta tttcgtgggc gtccatccgc      180

gagtcaggcg tcccagacag gttttcgggg tcgggttcgg ggacagattt cactttgaca      240

atcagctcac tgcaggcgga ggacgtggcg gtctactact gcttgcaata tcacgcaatt      300

ccctatactt ttgggcaggg aactaagttg gaaatcaagc ggacggtagc cgctccctcc      360

gtgttcatct ttccgccttc ggatgaacag ttgaaaagcg gaaccgcgtc ggtggtctgt      420

cttttgaata acttctaccc acgcgaggcc aaagtccagt ggaaagtaga taacgcgctt      480

cagtcaggga actcgcaaga gtcggtcact gaacaggaca gcaaagactc gacatactcc      540

ctctcctcca cgcttacgct tagcaaggcc gattatgaga agcacaaggt atacgcatgt      600

gaagtaaccc atcagggact ttcgtcccct gtgacgaaga gcttcaatcg gggagagtgc      660


<210> 48
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 48
Gly Phe Thr Phe Ser Trp Phe 
1               5           


<210> 49
<211> 660
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 49
gacattgtga tgacgcagtc accggattca ctggcagtgt cgctgggaga aagagcgacc       60

atcaattgca agagcagcca atcagtgttg tactcatcga acaataagaa cttcctcgcg      120

tggtatcaac agaaacccgg tcagcctccg aaattgctta tttcgtgggc gtccacgcgc      180

gagtcaggcg tcccagacag gttttcgggg tcgggttcgg ggacagattt cactttgaca      240

atcagctcac tgcaggcgga ggacgtggcg gtctactact gccagcaatt cttttccacg      300

cccttcactt ttgggccggg aactaaggtg gatatcaagc ggacggtagc cgctccctcc      360

gtgttcatct ttccgccttc ggatgaacag ttgaaaagcg gaaccgcgtc ggtggtctgt      420

cttttgaata acttctaccc acgcgaggcc aaagtccagt ggaaagtaga taacgcgctt      480

cagtcaggga actcgcaaga gtcggtcact gaacaggaca gcaaagactc gacatactcc      540

ctctcctcca cgcttacgct tagcaaggcc gattatgaga agcacaaggt atacgcatgt      600

gaagtaaccc atcagggact ttcgtcccct gtgacgaaga gcttcaatcg gggagagtgc      660


<210> 50
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 50
Gly Phe Thr Phe Ser Trp Asn 
1               5           


<210> 51
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 51
Gly Pro Ser Gly Gly Val 
1               5       


<210> 52
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 52
Ser Pro Ser Gly Gly Tyr 
1               5       


<210> 53
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 53
Gly Phe Thr Phe Ser Trp Tyr Trp 
1               5               


<210> 54
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 54
Gly Phe Thr Phe Ser Trp Phe Trp 
1               5               


<210> 55
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 55
Gly Phe Thr Phe Ser Trp Asn Trp 
1               5               


<210> 56
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 56
Ile Gly Pro Ser Gly Gly Val Thr 
1               5               


<210> 57
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 57
Ile Ser Pro Ser Gly Gly Tyr Thr 
1               5               


<210> 58
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 58
Ala Arg Asp Gly Ala Ala Ala Phe Asp Tyr 
1               5                   10  


<210> 59
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 59
Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr 
1               5                   10          


<210> 60
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 60
Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Phe 
1               5                   10          


