                         SEQUENCE LISTING

<110>  Acumen Pharmaceuticals Inc.
       Merck Sharp & Dohme Corp.
       Gore, William F.
       Hefti, Franz F.
       Gaspar, Renee C.
       Shughrue, Paul J.
       Fubao, Wang
       Wang, Weirong
       Zhang, Ningyuan
       Wei-Qin, Zhao
 
<120>  Method for Treating a Disease Associated With Soluble, Oligomeric
        Species of Amyloid Beta 1-42

<130>  API0026WO

<150>  US 13/693,362
<151>  2012-12-04

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa denotes N, S, T, A, D or E;  or Xaa denotes T, A, D, or E.

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa denotes N, H, Q, S, T, A or D; or Xaa denotes T.

<400>  1

Arg Ser Ser Gln Ser Ile Val His Ser Xaa Gly Xaa Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  2
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa denotes N, G, S, T or A; or Xaa denotes T.

<400>  2

Lys Ala Ser Xaa Arg Phe Ser 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa denotes R, K or Y.

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa denotes V, A or L.

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa denotes P, H or G.

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa denotes A, P or V.

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa denotes S, G, R or F.

<400>  3

Phe Gln Gly Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   


<210>  4
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  4

Gly Phe Thr Phe Ser Ser Phe Gly Met His 
1               5                   10  


<210>  5
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  5

Tyr Ile Ser Arg Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  6

Gly Ile Thr Thr Ala Leu Asp Tyr 
1               5               


<210>  7
<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Arg Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ile Thr Thr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  8
<211>  71
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala Pro Gly 
            20                  25                  30          


Lys Gly Leu Glu Trp Val Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        35                  40                  45              


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    50                  55                  60                  


Ala Val Tyr Tyr Cys Ala Arg 
65                  70      


<210>  9
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  9

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Ala Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser Arg Leu Gly Pro Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Leu 
            100                 105                 110         


<210>  10
<211>  70
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptice

<400>  10

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
            20                  25                  30          


Pro Gln Leu Leu Ile Tyr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
        35                  40                  45              


Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp 
    50                  55                  60                  


Val Gly Val Tyr Tyr Cys 
65                  70  


<210>  11
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetice oligonucleotide

<400>  11
tatggcttct agagatgtgg tgatg                                             25


<210>  12
<211>  82
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (59)..(60)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (62)..(63)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (65)..(66)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (68)..(69)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (71)..(72)
<223>  n is a, c, g, or t

<400>  12
tgcagccacc gtacgcttga tctccagctt ggtgccctgg ccaaaggtgg ggggcacmnn       60

mnnmnnmnnm nngcagtagt ag                                                82


<210>  13
<211>  70
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (47)..(48)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (50)..(51)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (53)..(54)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (56)..(57)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (59)..(60)
<223>  n is a, c, g, or t

<400>  13
tgcagccacc gtacgcttga tctccagctt ggtgccctgg ccaaamnnmn nmnnmnnmnn       60

gctgccctgg                                                              70


<210>  14
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  14
aggcggccct cgaggaggtg cagc                                              24


<210>  15
<211>  83
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (60)..(61)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (63)..(64)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (66)..(67)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (69)..(70)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (72)..(73)
<223>  n is a, c, g, or t

<400>  15
agaccgatgg gcccttggtg gaggcgctgg acacggtcac cagggtgccc tggccccamn       60

nmnnmnnmnn mnnggtgatg ccc                                               83


<210>  16
<211>  92
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (69)..(70)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (72)..(73)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (75)..(76)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (78)..(79)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (81)..(82)
<223>  n is a, c, g, or t

<400>  16
agaccgatgg gcccttggtg gaggcgctgg acacggtcac cagggtgccc tggccccagt       60

agtccagmnn mnnmnnmnnm nnccgggcac ag                                     92


<210>  17
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  17

Phe Gln Gly Ser His Val Pro Pro Thr 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  18

Phe Gln Gly Ser Arg Leu Gly Pro Ser 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  19

Phe Gln Gly Ser Arg Val Pro Ala Ser 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  20

Phe Gln Gly Ser Arg Val Pro Pro Gly 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  21

Phe Gln Gly Ser Lys Ala His Pro Ser 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  22

Phe Gln Gly Ser Tyr Ala Pro Pro Gly 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  23

Phe Gln Gly Ser Arg Ala Pro Pro Phe 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  24

Phe Gln Gly Ser Arg Val Pro Val Arg 
1               5                   


<210>  25
<211>  95
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  25

Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn 
1               5                   10                  15      


Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
            20                  25                  30          


Gln Leu Leu Ile Tyr Lys Ala Ser Asn Arg Phe Ser Gly Val Pro Asp 
        35                  40                  45              


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
    50                  55                  60                  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly Ser 
65                  70                  75                  80  


His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                85                  90                  95  


<210>  26
<211>  95
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  26

Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn 
1               5                   10                  15      


Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
            20                  25                  30          


Gln Leu Leu Ile Tyr Lys Ala Ser Asn Arg Phe Ser Gly Val Pro Asp 
        35                  40                  45              


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
    50                  55                  60                  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly Ser 
65                  70                  75                  80  


Arg Leu Gly Pro Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                85                  90                  95  


<210>  27
<211>  95
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  27

Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn 
1               5                   10                  15      


Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
            20                  25                  30          


Gln Leu Leu Ile Tyr Lys Ala Ser Asn Arg Phe Ser Gly Val Pro Asp 
        35                  40                  45              


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
    50                  55                  60                  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly Ser 
65                  70                  75                  80  


Arg Val Pro Ala Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                85                  90                  95  


<210>  28
<211>  95
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  28

Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn 
1               5                   10                  15      


Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
            20                  25                  30          


Gln Leu Leu Ile Tyr Lys Ala Ser Asn Arg Phe Ser Gly Val Pro Asp 
        35                  40                  45              


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
    50                  55                  60                  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly Ser 
65                  70                  75                  80  


Arg Val Pro Pro Gly Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                85                  90                  95  


<210>  29
<211>  95
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  29

Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn 
1               5                   10                  15      


Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
            20                  25                  30          


Gln Leu Leu Ile Tyr Lys Ala Ser Asn Arg Phe Ser Gly Val Pro Asp 
        35                  40                  45              


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
    50                  55                  60                  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly Ser 
65                  70                  75                  80  


Lys Ala His Pro Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                85                  90                  95  


<210>  30
<211>  95
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  30

Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn 
1               5                   10                  15      


Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
            20                  25                  30          


Gln Leu Leu Ile Tyr Lys Ala Ser Asn Arg Phe Ser Gly Val Pro Asp 
        35                  40                  45              


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
    50                  55                  60                  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly Ser 
65                  70                  75                  80  


Tyr Ala Pro Pro Gly Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                85                  90                  95  


<210>  31
<211>  95
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  31

Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn 
1               5                   10                  15      


Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
            20                  25                  30          


Gln Leu Leu Ile Tyr Lys Ala Ser Asn Arg Phe Ser Gly Val Pro Asp 
        35                  40                  45              


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
    50                  55                  60                  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly Ser 
65                  70                  75                  80  


Arg Ala Pro Pro Phe Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                85                  90                  95  


<210>  32
<211>  95
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  32

Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn 
1               5                   10                  15      


Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
            20                  25                  30          


Gln Leu Leu Ile Tyr Lys Ala Ser Asn Arg Phe Ser Gly Val Pro Asp 
        35                  40                  45              


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
    50                  55                  60                  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly Ser 
65                  70                  75                  80  


Arg Val Pro Val Arg Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                85                  90                  95  


<210>  33
<211>  981
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  33
gcatccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcc      120

tggaactctg gcgccctgac ctctggcgtg cacaccttcc ctgctgtgct gcaatcctct      180

ggcctgtact ccctgtcctc tgtggtgaca gtgccatcct ccaacttcgg cacccagacc      240

tacacatgca atgtggacca caagccatcc aacaccaagg tggacaagac agtggagcgg      300

aagtgctgtg tggagtgccc cccatgccct gccccccctg tggctggccc atctgtgttc      360

ctgttccccc ccaagcccaa ggacaccctg atgatctccc ggacccctga ggtgacctgt      420

gtggtggtgg acgtgtccca tgaggaccct gaggtgcagt tcaactggta tgtggatggc      480

gtggaggtgc acaatgccaa gaccaagccc cgggaggagc agttcaactc caccttccgg      540

gtggtgtctg tgctgacagt ggtgcaccag gactggctga atggcaagga gtacaagtgc      600

aaggtgtcca acaagggcct gcctgccccc atcgagaaga ccatctccaa gaccaagggc      660

cagccccggg agccccaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      720

caggtgtccc tgacctgcct ggtgaagggc ttctacccat ccgacattgc tgtggagtgg      780

gagtccaatg gccagcctga gaacaactac aagaccaccc cccccatgct ggactctgat      840

ggctccttct tcctgtactc caagctgaca gtggacaagt cccggtggca gcagggcaat      900

gtgttctcct gctctgtgat gcatgaggcc ctgcacaacc actacaccca gaagtccctg      960

tccctgtccc ctggcaagtg a                                                981


<210>  34
<211>  326
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  34

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  35
<211>  324
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  35
cgtacggtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg ttag                                             324


<210>  36
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  36

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  37
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  37
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa ctacaggtgt ccactcg          57


<210>  38
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  38

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  39
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  39
atgagtgtgc ccactcaggt cctggggttg ctgctgctgt ggcttacaga tgccagatgc       60


<210>  40
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  40

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys 
            20  


<210>  41
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  41

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  42
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  42

Arg Ser Ser Gln Ser Ile Val His Ser Ser Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  43
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  43

Arg Ser Ser Gln Ser Ile Val His Ser Thr Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  44
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  44

Arg Ser Ser Gln Ser Ile Val His Ser Ala Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  45
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  45

Arg Ser Ser Gln Ser Ile Val His Ser Glu Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  46
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  46

Arg Ser Ser Gln Ser Ile Val His Ser Asp Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  47
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  47

Arg Ser Ser Gln Ser Ile Val His Ser Ser Gly Gln Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  48
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  48

Arg Ser Ser Gln Ser Ile Val His Ser Ser Gly Ser Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  49
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  49

Arg Ser Ser Gln Ser Ile Val His Ser Ser Gly Thr Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  50
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  50

Arg Ser Ser Gln Ser Ile Val His Ser Ser Gly Ala Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  51
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  51

Lys Ala Ser Asn Arg Phe Ser 
1               5           


<210>  52
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  52

Lys Ala Ser Gln Arg Phe Ser 
1               5           


<210>  53
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  53

Lys Ala Ser Ser Arg Phe Ser 
1               5           


<210>  54
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  54

Lys Ala Ser Thr Arg Phe Ser 
1               5           


<210>  55
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  55

Lys Ala Ser Ala Arg Phe Ser 
1               5           


<210>  56
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  56

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  57
<211>  326
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  57

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  58
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  58

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  59
<211>  326
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  59

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Thr Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  60
<211>  354
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  60
gcttctagag atgtggtgat gacccagagc cccctgtccc tgcctgtgac ccctggcgag       60

cctgccagca tctcctgccg gagctcccag agcatcgtgc actccaatgg caacacctac      120

ctggagtggt acctgcagaa gcctggccag agcccccagc tgctgatcta caaggcttcc      180

aaccggttct ccggcgtgcc tgaccggttc agcggctccg gcagcggcac agacttcacc      240

ctgaagatca gccgggtgga ggctgaggat gtgggcgtct actactgctt ccagggcagc      300

cggcttggtc ctagttttgg ccagggcacc aagctggaga tcaagcgtac ggtg            354


<210>  61
<211>  351
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  61
gaggtgcagc tggtggagtc cggcggcggc ctggtgcagc ctggcggcag cctgcggctg       60

agctgtgctg cctctggctt caccttcagc tcctttggca tgcactgggt gcggcaggcc      120

cctggcaagg gcctggagtg ggtggcctac atcagccggg gctccagcac catctactat      180

gctgacacag tgaagggccg gttcaccatc agccgggaca atgccaagaa ctccctgtat      240

ctgcagatga acagcctgcg ggctgaggac acagcagtgt actactgtgc ccggggcatc      300

accacagccc tggactactg gggccagggc accctggtga ccgtgtccag c               351


<210>  62
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  62

Asn Ala Pro Val Ser Ile Pro Gln 
1               5               


