                         SEQUENCE LISTING

<110>  CNJ Holdings, Inc
 
<120>  Antibodies Against Clostridium Difficle

<130>  4328-006.3-PCT

<140>  PCT
<141>  2013-11-29

<150>  US 61/730,790
<151>  2012-11-28

<160>  784   

<170>  PatentIn version 3.5

<210>  1
<211>  546
<212>  PRT
<213>  Clostridium difficile

<400>  1

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
1               5                   10                  15      


Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          


Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              


Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
65                  70                  75                  80  


Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys 
                85                  90                  95      


Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
            100                 105                 110         


Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
        115                 120                 125             


Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 


Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn 
145                 150                 155                 160 


Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met 
                165                 170                 175     


Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala 
            180                 185                 190         


Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr 
        195                 200                 205             


Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr 
    210                 215                 220                 


Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val 
225                 230                 235                 240 


Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu 
                245                 250                 255     


Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu 
            260                 265                 270         


Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp 
        275                 280                 285             


Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro 
    290                 295                 300                 


Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile 
305                 310                 315                 320 


Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp 
                325                 330                 335     


Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser 
            340                 345                 350         


Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala 
        355                 360                 365             


Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn 
    370                 375                 380                 


Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val 
385                 390                 395                 400 


Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro 
                405                 410                 415     


Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile 
            420                 425                 430         


Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met 
        435                 440                 445             


Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr 
    450                 455                 460                 


Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp 
465                 470                 475                 480 


Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala 
                485                 490                 495     


Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr 
            500                 505                 510         


Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys 
        515                 520                 525             


Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly 
    530                 535                 540                 


Glu Asp 
545     


<210>  2
<211>  590
<212>  PRT
<213>  Clostridium difficile

<400>  2

Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val 
1               5                   10                  15      


Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu 
            20                  25                  30          


Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr 
        35                  40                  45              


Ile Asn Asn Phe Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp 
    50                  55                  60                  


Ser Leu Tyr Tyr Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe 
65                  70                  75                  80  


Val Thr Val Gly Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly 
                85                  90                  95      


Ala Ala Ser Ile Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe 
            100                 105                 110         


Asn Gln Ser Gly Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly 
        115                 120                 125             


Phe Lys Tyr Phe Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly 
    130                 135                 140                 


Glu Ala Ile Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr 
145                 150                 155                 160 


Tyr Phe Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp 
                165                 170                 175     


Gly Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly 
            180                 185                 190         


Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val 
        195                 200                 205             


Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp 
    210                 215                 220                 


Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His 
225                 230                 235                 240 


Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr 
                245                 250                 255     


Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn 
            260                 265                 270         


Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn 
        275                 280                 285             


Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys 
    290                 295                 300                 


Asp Leu Glu Asp Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu 
305                 310                 315                 320 


Ala Tyr Ile Gly Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn 
                325                 330                 335     


Asp Asp Gly Ile Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val 
            340                 345                 350         


Phe Tyr Phe Ser Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile 
        355                 360                 365             


Asp Asp Asn Tyr Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly 
    370                 375                 380                 


Val Phe Asp Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr 
385                 390                 395                 400 


Val Asn Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val 
                405                 410                 415     


Arg Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu 
            420                 425                 430         


Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe 
        435                 440                 445             


Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp 
    450                 455                 460                 


Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile 
465                 470                 475                 480 


Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln 
                485                 490                 495     


Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp 
            500                 505                 510         


Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr 
        515                 520                 525             


Phe Ala His Gln Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile 
    530                 535                 540                 


Asn Tyr Thr Gly Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr 
545                 550                 555                 560 


Asp Glu Tyr Ile Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu 
                565                 570                 575     


Tyr Tyr Phe Asp Pro Asp Thr Ala Gln Leu Val Ile Ser Glu 
            580                 585                 590 


<210>  3
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  3

Glu Lys Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Glu Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Ser Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Phe Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Val Lys 
            100                 105     


<210>  4
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  4

Ser Ser Val Ser Tyr 
1               5   


<210>  5
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  5

Glu Thr Ser 
1           


<210>  6
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  6

Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
1               5                   


<210>  7
<211>  26
<212>  PRT
<213>  Mus musculus

<400>  7

Glu Lys Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Glu Val Thr Met Thr Cys Ser Ala Ser 
            20                  25      


<210>  8
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  8

Met His Trp Tyr Gln Gln Lys Ser Ser Thr Ser Pro Lys Leu Trp Ile 
1               5                   10                  15      


Tyr 
    


<210>  9
<211>  36
<212>  PRT
<213>  Mus musculus

<400>  9

Lys Leu Ala Phe Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Val Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  10
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  10

Phe Gly Ser Gly Thr Lys Leu Glu Val Lys 
1               5                   10  


<210>  11
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  11

Glu Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Asp Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser His Val Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Phe Pro Tyr Asn Gly Ala Ala Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Leu Arg Val Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  12
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  12

Asp Tyr Ser Phe Thr Gly Tyr Tyr 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  13

Ile Phe Pro Tyr Asn Gly Ala Ala 
1               5               


<210>  14
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  14

Thr Arg Trp Leu Arg Val Tyr Phe Asp Tyr 
1               5                   10  


<210>  15
<211>  25
<212>  PRT
<213>  Mus musculus

<400>  15

Glu Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  16
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  16

Met His Trp Val Lys Gln Ser His Val Lys Ser Leu Glu Trp Ile Gly 
1               5                   10                  15      


Arg 
    


<210>  17
<211>  38
<212>  PRT
<213>  Mus musculus

<400>  17

Ser Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Glu Leu His Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  18
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  18

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  19
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  19

Glu Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Thr Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Ile Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  20
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  20

Ser Ser Val Thr Tyr 
1               5   


<210>  21
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  21

Glu Thr Ser 
1           


<210>  22
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  22

Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
1               5                   


<210>  23
<211>  26
<212>  PRT
<213>  Mus musculus

<400>  23

Glu Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Thr Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Ser Ala Ser 
            20                  25      


<210>  24
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  24

Met His Trp Tyr Gln Gln Lys Ser Ile Thr Ser Pro Lys Leu Trp Ile 
1               5                   10                  15      


Tyr 
    


<210>  25
<211>  36
<212>  PRT
<213>  Mus musculus

<400>  25

Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Val Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  26
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  26

Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  27
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  27

Glu Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Thr His Val Lys Ser Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Phe Pro Tyr Asn Gly Ala Ala Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Leu Arg Val Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  28
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  28

Gly Tyr Ser Phe Thr Gly Tyr Tyr 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  29

Ile Phe Pro Tyr Asn Gly Ala Ala 
1               5               


<210>  30
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  30

Ala Arg Trp Leu Arg Val Tyr Phe Asp Tyr 
1               5                   10  


<210>  31
<211>  25
<212>  PRT
<213>  Mus musculus

<400>  31

Glu Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  32
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  32

Ile His Trp Val Lys Gln Thr His Val Lys Ser Leu Glu Trp Val Gly 
1               5                   10                  15      


Arg 
    


<210>  33
<211>  38
<212>  PRT
<213>  Mus musculus

<400>  33

Ser Tyr Asn Gln Asn Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Glu Leu His Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Phe Cys 
        35              


<210>  34
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  34

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  35
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  35

Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ala Ala Ser Leu Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Pro Leu 
        35                  40                  45              


Ile His Arg Thr Ser Thr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu 
65                  70                  75                  80  


Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  36
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  36

Ser Ser Val Ser Ser Ser Tyr 
1               5           


<210>  37
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  37

Arg Thr Ser 
1           


<210>  38
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  38

Gln Gln Trp Ser Gly Tyr Pro Tyr Thr 
1               5                   


<210>  39
<211>  26
<212>  PRT
<213>  Mus musculus

<400>  39

Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ala Ala Ser Leu Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Thr Cys Ser Ala Ser 
            20                  25      


<210>  40
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  40

Leu His Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Pro Leu Ile 
1               5                   10                  15      


His 
    


<210>  41
<211>  36
<212>  PRT
<213>  Mus musculus

<400>  41

Thr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  42
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  42

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  43
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  43

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Ser Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Asn Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Arg Val Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  44
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  44

Gly Tyr Ser Ile Thr Ser Asp Ser Ala 
1               5                   


<210>  45
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  45

Ile Ser Tyr Ser Gly Ser Thr 
1               5           


<210>  46
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  46

Ala Arg Arg Ser Arg Val Ser Phe Tyr Phe Asp Tyr 
1               5                   10          


<210>  47
<211>  25
<212>  PRT
<213>  Mus musculus

<400>  47

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr 
            20                  25  


<210>  48
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  48

Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Asn Leu Glu Trp Met Gly 
1               5                   10                  15      


Tyr 
    


<210>  49
<211>  38
<212>  PRT
<213>  Mus musculus

<400>  49

Ser Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr 
1               5                   10                  15      


Ser Lys Asn Gln Phe Phe Leu Gln Leu Asn Ser Val Thr Thr Glu Asp 
            20                  25                  30          


Thr Ala Thr Tyr Tyr Cys 
        35              


<210>  50
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  50

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  51
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  51

Glu Asn Val Leu Thr Gln Ser Pro Thr Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Glu Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Ile Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  52
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  52

Ser Ser Val Thr Tyr 
1               5   


<210>  53
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  53

Glu Thr Ser 
1           


<210>  54
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  54

Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
1               5                   


<210>  55
<211>  26
<212>  PRT
<213>  Mus musculus

<400>  55

Glu Asn Val Leu Thr Gln Ser Pro Thr Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Glu Val Thr Met Thr Cys Ser Ala Ser 
            20                  25      


<210>  56
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  56

Met His Trp Tyr Gln Gln Lys Ser Ile Thr Ser Pro Lys Leu Trp Ile 
1               5                   10                  15      


Tyr 
    


<210>  57
<211>  36
<212>  PRT
<213>  Mus musculus

<400>  57

Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Val Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  58
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  58

Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  59
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  59

Glu Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Thr His Val Lys Ser Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Phe Pro Tyr Asn Gly Ala Ala Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Leu Arg Val Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  60
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  60

Gly Tyr Ser Phe Thr Gly Tyr Tyr 
1               5               


<210>  61
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  61

Ile Phe Pro Tyr Asn Gly Ala Ala 
1               5               


<210>  62
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  62

Ala Arg Trp Leu Arg Val Tyr Phe Asp Tyr 
1               5                   10  


<210>  63
<211>  25
<212>  PRT
<213>  Mus musculus

<400>  63

Glu Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  64
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  64

Ile His Trp Val Lys Gln Thr His Val Lys Ser Leu Glu Trp Val Gly 
1               5                   10                  15      


Arg 
    


<210>  65
<211>  38
<212>  PRT
<213>  Mus musculus

<400>  65

Ser Tyr Asn Gln Asn Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Ser Thr Thr Ala Tyr Met Glu Leu His Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Phe Cys 
        35              


<210>  66
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  66

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  67
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  67

Glu Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Thr Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Ile Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  68
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  68

Ser Ser Val Thr Tyr 
1               5   


<210>  69
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  69

Glu Thr Ser 
1           


<210>  70
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  70

Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
1               5                   


<210>  71
<211>  26
<212>  PRT
<213>  Mus musculus

<400>  71

Glu Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Thr Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Ser Ala Ser 
            20                  25      


<210>  72
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  72

Met His Trp Tyr Gln Gln Lys Ser Ile Thr Ser Pro Lys Leu Trp Ile 
1               5                   10                  15      


Tyr 
    


<210>  73
<211>  36
<212>  PRT
<213>  Mus musculus

<400>  73

Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Val Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  74
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  74

Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  75
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  75

Glu Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Thr His Val Lys Ser Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Phe Pro Tyr Asn Gly Ala Ala Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Leu Arg Val Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  76
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  76

Gly Tyr Ser Phe Thr Gly Tyr Tyr 
1               5               


<210>  77
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  77

Ile Phe Pro Tyr Asn Gly Ala Ala 
1               5               


<210>  78
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  78

Ala Arg Trp Leu Arg Val Tyr Phe Asp Tyr 
1               5                   10  


<210>  79
<211>  25
<212>  PRT
<213>  Mus musculus

<400>  79

Glu Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  80
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  80

Ile His Trp Val Lys Gln Thr His Val Lys Ser Leu Glu Trp Val Gly 
1               5                   10                  15      


Arg 
    


<210>  81
<211>  38
<212>  PRT
<213>  Mus musculus

<400>  81

Ser Tyr Asn Gln Asn Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Glu Leu His Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Phe Cys 
        35              


<210>  82
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  82

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  83
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  83

Asp Ile Gln Leu Thr Gln Ser Ser Ser Ser Phe Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Glu Tyr Thr Leu Ser Ile Ala Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Phe Val Thr Tyr Tyr Cys Gln Gln Tyr Trp Asn Ile Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 
            100                 105     


<210>  84
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  84

Glu Asp Ile Tyr Asn Arg 
1               5       


<210>  85
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  85

Gly Ala Thr 
1           


<210>  86
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  86

Gln Gln Tyr Trp Asn Ile Pro Thr 
1               5               


<210>  87
<211>  26
<212>  PRT
<213>  Mus musculus

<400>  87

Asp Ile Gln Leu Thr Gln Ser Ser Ser Ser Phe Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
            20                  25      


<210>  88
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  88

Leu Ala Trp Tyr Gln Gln Arg Pro Gly Asn Ala Pro Arg Leu Leu Ile 
1               5                   10                  15      


Ser 
    


<210>  89
<211>  36
<212>  PRT
<213>  Mus musculus

<400>  89

Ser Leu Glu Thr Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Lys Glu Tyr Thr Leu Ser Ile Ala Ser Leu Gln Thr Glu Asp Phe Val 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  90
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  90

Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 
1               5                   10  


<210>  91
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  91

Glu Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Val Asn Pro Tyr Asn Gly Asp Thr Asn Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Asn Trp Glu Asn Tyr Phe Asp Tyr Trp Gly Gln Gly Ser 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  92
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  92

Gly Tyr Ser Phe Thr Gly Tyr Tyr 
1               5               


<210>  93
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  93

Val Asn Pro Tyr Asn Gly Asp Thr 
1               5               


<210>  94
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  94

Thr Arg Ser Asn Trp Glu Asn Tyr Phe Asp Tyr 
1               5                   10      


<210>  95
<211>  25
<212>  PRT
<213>  Mus musculus

<400>  95

Glu Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  96
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  96

Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
1               5                   10                  15      


Arg 
    


<210>  97
<211>  38
<212>  PRT
<213>  Mus musculus

<400>  97

Asn Tyr Asn Gln Asn Phe Lys Asp Lys Ala Ile Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Ala Ser Thr Ala Tyr Met Glu Phe Arg Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  98
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  98

Trp Gly Gln Gly Ser Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  99
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  99

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Phe Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105     


<210>  100
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  100

Ser Ser Val Ser Tyr 
1               5   


<210>  101
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  101

Glu Thr Ser 
1           


<210>  102
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  102

Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
1               5                   


<210>  103
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  103

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser 
            20                  25      


<210>  104
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  104

Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  105
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  105

Lys Leu Ala Phe Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
            20                  25                  30          


Val Tyr Tyr Cys 
        35      


<210>  106
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  106

Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
1               5                   10  


<210>  107
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  107

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Phe Pro Tyr Asn Gly Ala Ala Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Leu Arg Val Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  108
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  108

Gly Tyr Thr Phe Thr Gly Tyr Tyr 
1               5               


<210>  109
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  109

Ile Phe Pro Tyr Asn Gly Ala Ala 
1               5               


<210>  110
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  110

Ala Arg Trp Leu Arg Val Tyr Phe Asp Tyr 
1               5                   10  


<210>  111
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  111

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  112
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  112

Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Arg 
    


<210>  113
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  113

Ser Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Ile Thr Ala Asp Glu 
1               5                   10                  15      


Ser Thr Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  114
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  114

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  115
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  115

Glu Lys Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Phe Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105     


<210>  116
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  116

Ser Ser Val Ser Tyr 
1               5   


<210>  117
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  117

Glu Thr Ser 
1           


<210>  118
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  118

Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
1               5                   


<210>  119
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  119

Glu Lys Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Met Thr Cys Ser Ala Ser 
            20                  25      


<210>  120
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  120

Met His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile 
1               5                   10                  15      


Tyr 
    


<210>  121
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  121

Lys Leu Ala Phe Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Asn Ser Tyr Ser Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
            20                  25                  30          


Val Tyr Tyr Cys 
        35      


<210>  122
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  122

Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
1               5                   10  


<210>  123
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  123

Glu Val Gln Leu Leu Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Asp Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Phe Pro Tyr Asn Gly Ala Ala Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu His Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Leu Arg Val Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  124
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  124

Asp Tyr Ser Phe Thr Gly Tyr Tyr 
1               5               


<210>  125
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  125

Ile Phe Pro Tyr Asn Gly Ala Ala 
1               5               


<210>  126
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  126

Thr Arg Trp Leu Arg Val Tyr Phe Asp Tyr 
1               5                   10  


<210>  127
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  127

Glu Val Gln Leu Leu Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  128
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  128

Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Arg 
    


<210>  129
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  129

Ser Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Glu Leu His Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  130
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  130

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  131
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  131

Glu Lys Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Phe Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105     


<210>  132
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  132

Ser Ser Val Ser Tyr 
1               5   


<210>  133
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  133

Glu Thr Ser 
1           


<210>  134
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  134

Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
1               5                   


<210>  135
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  135

Glu Lys Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Ser Cys Ser Ala Ser 
            20                  25      


<210>  136
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  136

Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Trp Ile 
1               5                   10                  15      


Tyr 
    


<210>  137
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  137

Lys Leu Ala Phe Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Glu Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  138
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  138

Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
1               5                   10  


<210>  139
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  139

Glu Val Gln Leu Leu Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Phe Pro Tyr Asn Gly Ala Ala Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Leu Arg Val Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  140
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  140

Gly Tyr Ser Phe Thr Gly Tyr Tyr 
1               5               


<210>  141
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  141

Ile Phe Pro Tyr Asn Gly Ala Ala 
1               5               


<210>  142
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  142

Thr Arg Trp Leu Arg Val Tyr Phe Asp Tyr 
1               5                   10  


<210>  143
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  143

Glu Val Gln Leu Leu Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  144
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  144

Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Arg 
    


<210>  145
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  145

Ser Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys 
1               5                   10                  15      


Ser Thr Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  146
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  146

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  147
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  147

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  148
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  148

Ser Ser Val Ser Ser Ser Tyr 
1               5           


<210>  149
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  149

Arg Thr Ser 
1           


<210>  150
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  150

Gln Gln Trp Ser Gly Tyr Pro Tyr Thr 
1               5                   


<210>  151
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  151

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser 
            20                  25      


<210>  152
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  152

Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  153
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  153

Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  154
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  154

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  155
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  155

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asp 
            20                  25                  30          


Ser Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Val Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Arg Val Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  156
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  156

Gly Gly Ser Ile Ser Ser Asp Ser Ala 
1               5                   


<210>  157
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  157

Ile Ser Tyr Ser Gly Ser Thr 
1               5           


<210>  158
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  158

Ala Arg Arg Ser Arg Val Ser Phe Tyr Phe Asp Tyr 
1               5                   10          


<210>  159
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  159

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  160
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  160

Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Tyr 
    


<210>  161
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  161

Ser Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr 
1               5                   10                  15      


Ser Lys Asn Gln Phe Ser Leu Lys Val Asn Ser Val Thr Ala Ala Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  162
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  162

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  163
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  163

Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Pro Leu 
        35                  40                  45              


Ile His Arg Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  164
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  164

Ser Ser Val Ser Ser Ser Tyr 
1               5           


<210>  165
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  165

Arg Thr Ser 
1           


<210>  166
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  166

Gln Gln Trp Ser Gly Tyr Pro Tyr Thr 
1               5                   


<210>  167
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  167

Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser 
            20                  25      


<210>  168
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  168

Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Pro Leu Ile 
1               5                   10                  15      


His 
    


<210>  169
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  169

Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Ser Tyr Ser Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  170
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  170

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  171
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  171

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Ser Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Asn Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Val Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Arg Val Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  172
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  172

Gly Tyr Ser Ile Thr Ser Asp Ser Ala 
1               5                   


<210>  173
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  173

Ile Ser Tyr Ser Gly Ser Thr 
1               5           


<210>  174
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  174

Ala Arg Arg Ser Arg Val Ser Phe Tyr Phe Asp Tyr 
1               5                   10          


<210>  175
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  175

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Thr 
            20                  25  


<210>  176
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  176

Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Asn Leu Glu Trp Met Gly 
1               5                   10                  15      


Tyr 
    


<210>  177
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  177

Ser Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr 
1               5                   10                  15      


Ser Lys Asn Gln Phe Ser Leu Lys Val Asn Ser Val Thr Ala Ala Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  178
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  178

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  179
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  179

Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu 
        35                  40                  45              


Ile His Arg Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Gln 
65                  70                  75                  80  


Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  180
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  180

Ser Ser Val Ser Ser Ser Tyr 
1               5           


<210>  181
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  181

Arg Thr Ser 
1           


<210>  182
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  182

Gln Gln Trp Ser Gly Tyr Pro Tyr Thr 
1               5                   


<210>  183
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  183

Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser 
            20                  25      


<210>  184
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  184

Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
1               5                   10                  15      


His 
    


<210>  185
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  185

Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Gln Pro Glu Asp Ile Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  186
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  186

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  187
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  187

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Ser Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Asn Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Arg Val Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  188
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  188

Gly Tyr Ser Ile Thr Ser Asp Ser Ala 
1               5                   


<210>  189
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  189

Ile Ser Tyr Ser Gly Ser Thr 
1               5           


<210>  190
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  190

Ala Arg Arg Ser Arg Val Ser Phe Tyr Phe Asp Tyr 
1               5                   10          


<210>  191
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  191

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Thr 
            20                  25  


<210>  192
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  192

Trp Asn Trp Ile Arg Gln Pro Pro Gly Asn Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Tyr 
    


<210>  193
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  193

Ser Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr 
1               5                   10                  15      


Ser Lys Asn Gln Phe Ser Leu Lys Leu Asn Ser Val Thr Ala Ala Asp 
            20                  25                  30          


Thr Ala Thr Tyr Tyr Cys 
        35              


<210>  194
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  194

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  195
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  195

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  196
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  196

Ser Ser Val Thr Tyr 
1               5   


<210>  197
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  197

Glu Thr Ser 
1           


<210>  198
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  198

Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
1               5                   


<210>  199
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  199

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser 
            20                  25      


<210>  200
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  200

Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  201
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  201

Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  202
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  202

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  203
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  203

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Tyr Asn Gly Ala Ala Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Leu Arg Val Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  204
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  204

Gly Tyr Thr Phe Thr Gly Tyr Tyr 
1               5               


<210>  205
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  205

Ile Phe Pro Tyr Asn Gly Ala Ala 
1               5               


<210>  206
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  206

Ala Arg Trp Leu Arg Val Tyr Phe Asp Tyr 
1               5                   10  


<210>  207
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  207

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  208
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  208

Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Arg 
    


<210>  209
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  209

Ser Tyr Asn Gln Asn Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys 
1               5                   10                  15      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  210
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  210

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  211
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  211

Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  212
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  212

Ser Ser Val Thr Tyr 
1               5   


<210>  213
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  213

Glu Thr Ser 
1           


<210>  214
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  214

Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
1               5                   


<210>  215
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  215

Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser 
            20                  25      


<210>  216
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  216

Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp Ile 
1               5                   10                  15      


Tyr 
    


<210>  217
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  217

Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Asn Ser Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  218
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  218

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  219
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  219

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Phe Pro Tyr Asn Gly Ala Ala Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Leu Arg Val Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  220
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  220

Gly Tyr Ser Phe Thr Gly Tyr Tyr 
1               5               


<210>  221
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  221

Ile Phe Pro Tyr Asn Gly Ala Ala 
1               5               


<210>  222
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  222

Ala Arg Trp Leu Arg Val Tyr Phe Asp Tyr 
1               5                   10  


<210>  223
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  223

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  224
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  224

Ile His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Val Gly 
1               5                   10                  15      


Arg 
    


<210>  225
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  225

Ser Tyr Asn Gln Asn Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Ser Thr Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Phe Cys 
        35              


<210>  226
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  226

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  227
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  227

Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  228
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  228

Ser Ser Val Thr Tyr 
1               5   


<210>  229
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  229

Glu Thr Ser 
1           


<210>  230
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  230

Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
1               5                   


<210>  231
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  231

Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser 
            20                  25      


<210>  232
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  232

Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile 
1               5                   10                  15      


Tyr 
    


<210>  233
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  233

Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Asn Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Val Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  234
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  234

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  235
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  235

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Thr Pro Gly Gln Ser Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Phe Pro Tyr Asn Gly Ala Ala Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Leu Arg Val Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  236
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  236

Gly Tyr Ser Phe Thr Gly Tyr Tyr 
1               5               


<210>  237
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  237

Ile Phe Pro Tyr Asn Gly Ala Ala 
1               5               


<210>  238
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  238

Ala Arg Trp Leu Arg Val Tyr Phe Asp Tyr 
1               5                   10  


<210>  239
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  239

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  240
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  240

Ile His Trp Val Lys Gln Thr Pro Gly Gln Ser Leu Glu Trp Val Gly 
1               5                   10                  15      


Arg 
    


<210>  241
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  241

Ser Tyr Asn Gln Asn Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Thr Thr Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Phe Cys 
        35              


<210>  242
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  242

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  243
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  243

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  244
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  244

Ser Ser Val Thr Tyr 
1               5   


<210>  245
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  245

Glu Thr Ser 
1           


<210>  246
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  246

Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
1               5                   


<210>  247
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  247

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser 
            20                  25      


<210>  248
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  248

Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  249
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  249

Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  250
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  250

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  251
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  251

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Tyr Asn Gly Ala Ala Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Leu Arg Val Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  252
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  252

Gly Tyr Thr Phe Thr Gly Tyr Tyr 
1               5               


<210>  253
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  253

Ile Phe Pro Tyr Asn Gly Ala Ala 
1               5               


<210>  254
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  254

Ala Arg Trp Leu Arg Val Tyr Phe Asp Tyr 
1               5                   10  


<210>  255
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  255

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  256
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  256

Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Arg 
    


<210>  257
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  257

Ser Tyr Asn Gln Asn Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys 
1               5                   10                  15      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  258
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  258

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  259
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  259

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  260
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  260

Ser Ser Val Thr Tyr 
1               5   


<210>  261
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  261

Glu Thr Ser 
1           


<210>  262
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  262

Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
1               5                   


<210>  263
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  263

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser 
            20                  25      


<210>  264
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  264

Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp Ile 
1               5                   10                  15      


Tyr 
    


<210>  265
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  265

Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Asn Ser Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  266
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  266

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  267
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  267

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Phe Pro Tyr Asn Gly Ala Ala Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Leu Arg Val Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  268
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  268

Gly Tyr Ser Phe Thr Gly Tyr Tyr 
1               5               


<210>  269
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  269

Ile Phe Pro Tyr Asn Gly Ala Ala 
1               5               


<210>  270
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  270

Ala Arg Trp Leu Arg Val Tyr Phe Asp Tyr 
1               5                   10  


<210>  271
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  271

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  272
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  272

Ile His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Val Gly 
1               5                   10                  15      


Arg 
    


<210>  273
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  273

Ser Tyr Asn Gln Asn Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Phe Cys 
        35              


<210>  274
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  274

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  275
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  275

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Ser Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  276
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  276

Ser Ser Val Thr Tyr 
1               5   


<210>  277
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  277

Glu Thr Ser 
1           


<210>  278
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  278

Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
1               5                   


<210>  279
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  279

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Ser Cys Ser Ala Ser 
            20                  25      


<210>  280
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  280

Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile 
1               5                   10                  15      


Tyr 
    


<210>  281
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  281

Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Asn Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Val Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  282
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  282

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  283
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  283

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Thr Pro Gly Gln Ser Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Phe Pro Tyr Asn Gly Ala Ala Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Leu Arg Val Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  284
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  284

Gly Tyr Ser Phe Thr Gly Tyr Tyr 
1               5               


<210>  285
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  285

Ile Phe Pro Tyr Asn Gly Ala Ala 
1               5               


<210>  286
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  286

Ala Arg Trp Leu Arg Val Tyr Phe Asp Tyr 
1               5                   10  


<210>  287
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  287

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  288
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  288

Ile His Trp Val Lys Gln Thr Pro Gly Gln Ser Leu Glu Trp Val Gly 
1               5                   10                  15      


Arg 
    


<210>  289
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  289

Ser Tyr Asn Gln Asn Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Phe Cys 
        35              


<210>  290
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  290

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  291
<211>  318
<212>  DNA
<213>  Mus musculus

<400>  291
gaaaaggttc tcacccagtc tccagcaatc atgtctgcat ctccagggga agaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tacatgcatt ggtaccagca gaagtcaagc      120

acctccccca aactctggat ttatgaaaca tccaaactgg cttttggagt cccaggtcgc      180

ttcagtggca gtggatctgg aaactcttac tctctcacga tcagcagcat ggaggctgaa      240

gatgttgcca cttattactg ttttcagggg agtgggtacc cattcacgtt cggctcgggg      300

acaaagttgg aagtaaaa                                                    318


<210>  292
<211>  15
<212>  DNA
<213>  Mus musculus

<400>  292
tcaagtgtaa gttac                                                        15


<210>  293
<211>  9
<212>  DNA
<213>  Mus musculus

<400>  293
gaaacatcc                                                                9


<210>  294
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  294
tttcagggga gtgggtaccc attcacg                                           27


<210>  295
<211>  78
<212>  DNA
<213>  Mus musculus

<400>  295
gaaaaggttc tcacccagtc tccagcaatc atgtctgcat ctccagggga agaggtcacc       60

atgacctgca gtgccagc                                                     78


<210>  296
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  296
atgcattggt accagcagaa gtcaagcacc tcccccaaac tctggattta t                51


<210>  297
<211>  108
<212>  DNA
<213>  Mus musculus

<400>  297
aaactggctt ttggagtccc aggtcgcttc agtggcagtg gatctggaaa ctcttactct       60

ctcacgatca gcagcatgga ggctgaagat gttgccactt attactgt                   108


<210>  298
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  298
ttcggctcgg ggacaaagtt ggaagtaaaa                                        30


<210>  299
<211>  351
<212>  DNA
<213>  Mus musculus

<400>  299
gaggtccagc tgctacagtc tggccctgag ctggtgaagc ctggggcttc agtgaagata       60

tcctgcaagg cttctgatta ctcattcact ggctactaca tgcactgggt gaagcaaagc      120

catgtaaaga gccttgagtg gattggacgt atttttcctt acaatggtgc tgctagctac      180

aaccagaatt tcaaggacaa ggccaccttg actgtagata agtcttccag cacagcctac      240

atggagctcc acagcctgac atctgaggac tctgcagtct attattgtac aagatggtta      300

agggtctact ttgactactg gggccaaggc accactctca cagtctcctc a               351


<210>  300
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  300
gattactcat tcactggcta ctac                                              24


<210>  301
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  301
atttttcctt acaatggtgc tgct                                              24


<210>  302
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  302
acaagatggt taagggtcta ctttgactac                                        30


<210>  303
<211>  75
<212>  DNA
<213>  Mus musculus

<400>  303
gaggtccagc tgctacagtc tggccctgag ctggtgaagc ctggggcttc agtgaagata       60

tcctgcaagg cttct                                                        75


<210>  304
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  304
atgcactggg tgaagcaaag ccatgtaaag agccttgagt ggattggacg t                51


<210>  305
<211>  114
<212>  DNA
<213>  Mus musculus

<400>  305
agctacaacc agaatttcaa ggacaaggcc accttgactg tagataagtc ttccagcaca       60

gcctacatgg agctccacag cctgacatct gaggactctg cagtctatta ttgt            114


<210>  306
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  306
tggggccaag gcaccactct cacagtctcc tca                                    33


<210>  307
<211>  319
<212>  DNA
<213>  Mus musculus

<400>  307
gaaattgttc tcacccagtc tccagcaatc atgtctacat ctccagggga aaaggtcacc       60

atgtcctgca gtgccagctc aagtgtaact tacatgcact ggtaccagca gaagtcaatc      120

acctccccca aactctggat ttatgaaaca tccaaactgg cttctggagt ccccggtcgc      180

ttcagtggca gtgggtctgg aaactcttac tctctcacga tcagcagcat ggaggctgaa      240

gatgttgcca cttattactg ttttcagggg agtgggtacc cattcacgtt cggctcgggg      300

acaaagttgg aaataaaac                                                   319


<210>  308
<211>  15
<212>  DNA
<213>  Mus musculus

<400>  308
tcaagtgtaa cttac                                                        15


<210>  309
<211>  9
<212>  DNA
<213>  Mus musculus

<400>  309
gaaacatcc                                                                9


<210>  310
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  310
tttcagggga gtgggtaccc attcacg                                           27


<210>  311
<211>  78
<212>  DNA
<213>  Mus musculus

<400>  311
gaaattgttc tcacccagtc tccagcaatc atgtctacat ctccagggga aaaggtcacc       60

atgtcctgca gtgccagc                                                     78


<210>  312
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  312
atgcactggt accagcagaa gtcaatcacc tcccccaaac tctggattta t                51


<210>  313
<211>  108
<212>  DNA
<213>  Mus musculus

<400>  313
aaactggctt ctggagtccc cggtcgcttc agtggcagtg ggtctggaaa ctcttactct       60

ctcacgatca gcagcatgga ggctgaagat gttgccactt attactgt                   108


<210>  314
<211>  31
<212>  DNA
<213>  Mus musculus

<400>  314
ttcggctcgg ggacaaagtt ggaaataaaa c                                      31


<210>  315
<211>  352
<212>  DNA
<213>  Mus musculus

<400>  315
gaggtccagc tgctacagtc tggccctgag ctggtgaagc ctgggacttc agtgaagata       60

tcctgcaagg cttctggtta ctcattcact ggctactaca tacactgggt gaagcagacc      120

catgtaaaga gccttgagtg ggttggacgt atttttcctt acaatggtgc tgctagctac      180

aatcagaatt tcaagggcaa ggccaccttg actgtagata agtcctccag cacagcctac      240

atggagctcc acagcctgac atctgaggac tctgcagtct atttctgtgc aagatggtta      300

agggtctact ttgactactg gggccaaggc accactctca cagtctcctc ag              352


<210>  316
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  316
ggttactcat tcactggcta ctac                                              24


<210>  317
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  317
atttttcctt acaatggtgc tgct                                              24


<210>  318
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  318
gcaagatggt taagggtcta ctttgactac                                        30


<210>  319
<211>  75
<212>  DNA
<213>  Mus musculus

<400>  319
gaggtccagc tgctacagtc tggccctgag ctggtgaagc ctgggacttc agtgaagata       60

tcctgcaagg cttct                                                        75


<210>  320
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  320
atacactggg tgaagcagac ccatgtaaag agccttgagt gggttggacg t                51


<210>  321
<211>  114
<212>  DNA
<213>  Mus musculus

<400>  321
agctacaatc agaatttcaa gggcaaggcc accttgactg tagataagtc ctccagcaca       60

gcctacatgg agctccacag cctgacatct gaggactctg cagtctattt ctgt            114


<210>  322
<211>  34
<212>  DNA
<213>  Mus musculus

<400>  322
tggggccaag gcaccactct cacagtctcc tcag                                   34


<210>  323
<211>  324
<212>  DNA
<213>  Mus musculus

<400>  323
gaaaatgtgc tcacccagtc tccagcaata atggctgcct ctctggggca gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tccagttact tgcactggta ccagcagaag      120

tcaggcgctt cccccaaacc cttgattcat aggacatcca ccctggcttc tggcgtccca      180

gctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag cagcgtggag      240

gctgaagatg atgcaactta ttactgccag cagtggagtg gttacccgta cacgttcgga      300

ggggggacca agctggaaat aaaa                                             324


<210>  324
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  324
tcaagtgtaa gttccagtta c                                                 21


<210>  325
<211>  9
<212>  DNA
<213>  Mus musculus

<400>  325
aggacatcc                                                                9


<210>  326
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  326
cagcagtgga gtggttaccc gtacacg                                           27


<210>  327
<211>  78
<212>  DNA
<213>  Mus musculus

<400>  327
gaaaatgtgc tcacccagtc tccagcaata atggctgcct ctctggggca gaaggtcacc       60

atgacctgca gtgccagc                                                     78


<210>  328
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  328
ttgcactggt accagcagaa gtcaggcgct tcccccaaac ccttgattca t                51


<210>  329
<211>  108
<212>  DNA
<213>  Mus musculus

<400>  329
accctggctt ctggcgtccc agctcgcttc agtggcagtg ggtctgggac ctcttactct       60

ctcacaatca gcagcgtgga ggctgaagat gatgcaactt attactgc                   108


<210>  330
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  330
ttcggagggg ggaccaagct ggaaataaaa                                        30


<210>  331
<211>  358
<212>  DNA
<213>  Mus musculus

<400>  331
gatgtgcagc ttcaggagtc aggacctggc ctggtgaaac cttctcagtc tctgtccctc       60

acctgcactg tcactggcta ctcaatcacc agtgattctg cctggaactg gatccggcag      120

tttccaggaa acaacctgga gtggatgggc tacataagct acagtggtag cactagctac      180

aacccatctc tcaaaagtcg aatctctatc actcgagaca catccaagaa ccagttcttc      240

ctgcagttga attctgtgac tactgaggac acagccacat attactgtgc aagaaggagt      300

agggtctcat tctactttga ctactggggc caaggcacca ctctcacagt ctcctcag        358


<210>  332
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  332
ggctactcaa tcaccagtga ttctgcc                                           27


<210>  333
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  333
ataagctaca gtggtagcac t                                                 21


<210>  334
<211>  36
<212>  DNA
<213>  Mus musculus

<400>  334
gcaagaagga gtagggtctc attctacttt gactac                                 36


<210>  335
<211>  75
<212>  DNA
<213>  Mus musculus

<400>  335
gatgtgcagc ttcaggagtc aggacctggc ctggtgaaac cttctcagtc tctgtccctc       60

acctgcactg tcact                                                        75


<210>  336
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  336
tggaactgga tccggcagtt tccaggaaac aacctggagt ggatgggcta c                51


<210>  337
<211>  114
<212>  DNA
<213>  Mus musculus

<400>  337
agctacaacc catctctcaa aagtcgaatc tctatcactc gagacacatc caagaaccag       60

ttcttcctgc agttgaattc tgtgactact gaggacacag ccacatatta ctgt            114


<210>  338
<211>  34
<212>  DNA
<213>  Mus musculus

<400>  338
tggggccaag gcaccactct cacagtctcc tcag                                   34


<210>  339
<211>  319
<212>  DNA
<213>  Mus musculus

<400>  339
gaaaatgttc tcacccagtc tccaacaatc atgtctgcat ctccagggga agaggtcacc       60

atgacctgca gtgccagctc aagtgtaact tacatgcact ggtaccagca gaagtcaatc      120

acctccccca aactctggat ttatgaaaca tccaaactgg cttctggagt cccaggtcgc      180

ttcagtggca gtgggtctgg aaactcttac tctctcacga tcagcagcat ggaggctgaa      240

gatgttgcca cttattactg ttttcagggg agtgggtacc cattcacgtt cggctcgggg      300

acaaagttgg aaataaaac                                                   319


<210>  340
<211>  15
<212>  DNA
<213>  Mus musculus

<400>  340
tcaagtgtaa cttac                                                        15


<210>  341
<211>  9
<212>  DNA
<213>  Mus musculus

<400>  341
gaaacatcc                                                                9


<210>  342
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  342
tttcagggga gtgggtaccc attcacg                                           27


<210>  343
<211>  78
<212>  DNA
<213>  Mus musculus

<400>  343
gaaaatgttc tcacccagtc tccaacaatc atgtctgcat ctccagggga agaggtcacc       60

atgacctgca gtgccagc                                                     78


<210>  344
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  344
atgcactggt accagcagaa gtcaatcacc tcccccaaac tctggattta t                51


<210>  345
<211>  108
<212>  DNA
<213>  Mus musculus

<400>  345
aaactggctt ctggagtccc aggtcgcttc agtggcagtg ggtctggaaa ctcttactct       60

ctcacgatca gcagcatgga ggctgaagat gttgccactt attactgt                   108


<210>  346
<211>  31
<212>  DNA
<213>  Mus musculus

<400>  346
ttcggctcgg ggacaaagtt ggaaataaaa c                                      31


<210>  347
<211>  352
<212>  DNA
<213>  Mus musculus

<400>  347
gaggtccagc tgctacagtc tggccctgag ctggtgaagc ctgggacttc agtgaagata       60

tcctgcaagg cttctggtta ctcattcact ggctactaca ttcactgggt gaagcagacc      120

catgtaaaga gccttgagtg ggttggacgt atttttcctt acaatggtgc tgctagctac      180

aaccagaatt tcaagggcaa ggccaccttg actgtagata agtcctccac cacagcctac      240

atggagctcc acagcctgac atctgaggac tctgcagtct atttctgtgc aagatggtta      300

agggtctact ttgactactg gggccaaggc accactctca cagtctcctc ag              352


<210>  348
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  348
ggttactcat tcactggcta ctac                                              24


<210>  349
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  349
atttttcctt acaatggtgc tgct                                              24


<210>  350
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  350
gcaagatggt taagggtcta ctttgactac                                        30


<210>  351
<211>  75
<212>  DNA
<213>  Mus musculus

<400>  351
gaggtccagc tgctacagtc tggccctgag ctggtgaagc ctgggacttc agtgaagata       60

tcctgcaagg cttct                                                        75


<210>  352
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  352
attcactggg tgaagcagac ccatgtaaag agccttgagt gggttggacg t                51


<210>  353
<211>  114
<212>  DNA
<213>  Mus musculus

<400>  353
agctacaacc agaatttcaa gggcaaggcc accttgactg tagataagtc ctccaccaca       60

gcctacatgg agctccacag cctgacatct gaggactctg cagtctattt ctgt            114


<210>  354
<211>  34
<212>  DNA
<213>  Mus musculus

<400>  354
tggggccaag gcaccactct cacagtctcc tcag                                   34


<210>  355
<211>  319
<212>  DNA
<213>  Mus musculus

<400>  355
gaaattgttc tcacccagtc tccagcaatc atgtctacat ctccagggga aaaggtcacc       60

atgtcctgca gtgccagctc aagtgtaact tacatgcact ggtaccagca gaagtcaatc      120

acctccccca aactctggat ttatgaaaca tccaaactgg cttctggagt ccccggtcgc      180

ttcagtggca gtgggtctgg aaactcttac tctctcacga tcagcagcat ggaggctgaa      240

gatgttgcca cttattactg ttttcagggg agtgggtacc cattcacgtt cggctcgggg      300

acaaagttgg aaataaaac                                                   319


<210>  356
<211>  15
<212>  DNA
<213>  Mus musculus

<400>  356
tcaagtgtaa cttac                                                        15


<210>  357
<211>  9
<212>  DNA
<213>  Mus musculus

<400>  357
gaaacatcc                                                                9


<210>  358
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  358
tttcagggga gtgggtaccc attcacg                                           27


<210>  359
<211>  78
<212>  DNA
<213>  Mus musculus

<400>  359
gaaattgttc tcacccagtc tccagcaatc atgtctacat ctccagggga aaaggtcacc       60

atgtcctgca gtgccagc                                                     78


<210>  360
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  360
atgcactggt accagcagaa gtcaatcacc tcccccaaac tctggattta t                51


<210>  361
<211>  108
<212>  DNA
<213>  Mus musculus

<400>  361
aaactggctt ctggagtccc cggtcgcttc agtggcagtg ggtctggaaa ctcttactct       60

ctcacgatca gcagcatgga ggctgaagat gttgccactt attactgt                   108


<210>  362
<211>  31
<212>  DNA
<213>  Mus musculus

<400>  362
ttcggctcgg ggacaaagtt ggaaataaaa c                                      31


<210>  363
<211>  352
<212>  DNA
<213>  Mus musculus

<400>  363
gaggtccagc tgctacagtc tggccctgag ctggtgaagc ctgggacttc agtgaagata       60

tcctgcaagg cttctggtta ctcattcact ggctactaca tacactgggt gaagcagacc      120

catgtaaaga gccttgagtg ggttggacgt atttttcctt acaatggtgc tgctagctac      180

aatcagaatt tcaagggcaa ggccaccttg actgtagata agtcctccag cacagcctac      240

atggagctcc acagcctgac atctgaggac tctgcagtct atttctgtgc aagatggtta      300

agggtctact ttgactactg gggccaaggc accactctca cagtctcctc ag              352


<210>  364
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  364
ggttactcat tcactggcta ctac                                              24


<210>  365
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  365
atttttcctt acaatggtgc tgct                                              24


<210>  366
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  366
gcaagatggt taagggtcta ctttgactac                                        30


<210>  367
<211>  75
<212>  DNA
<213>  Mus musculus

<400>  367
gaggtccagc tgctacagtc tggccctgag ctggtgaagc ctgggacttc agtgaagata       60

tcctgcaagg cttct                                                        75


<210>  368
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  368
atacactggg tgaagcagac ccatgtaaag agccttgagt gggttggacg t                51


<210>  369
<211>  114
<212>  DNA
<213>  Mus musculus

<400>  369
agctacaatc agaatttcaa gggcaaggcc accttgactg tagataagtc ctccagcaca       60

gcctacatgg agctccacag cctgacatct gaggactctg cagtctattt ctgt            114


<210>  370
<211>  34
<212>  DNA
<213>  Mus musculus

<400>  370
tggggccaag gcaccactct cacagtctcc tcag                                   34


<210>  371
<211>  319
<212>  DNA
<213>  Mus musculus

<400>  371
gacatccagc tgacacaatc ttcatcctcc tattctgtat ctctaggaga cagggtcacc       60

attacttgca aggcaagtga ggacatatat aatcggttag cctggtatca gcagagacca      120

ggaaatgctc ctaggctctt aatatctggt gcaaccagtt tggaaactgg gattccttca      180

agattcagtg gcagtggatc tggaaaggag tacactctca gcattgccag tcttcagact      240

gaagattttg ttacttatta ctgtcaacaa tattggaata ttccgacgtt cggtggaggc      300

accaggctgg aaatcaaac                                                   319


<210>  372
<211>  18
<212>  DNA
<213>  Mus musculus

<400>  372
gaggacatat ataatcgg                                                     18


<210>  373
<211>  9
<212>  DNA
<213>  Mus musculus

<400>  373
ggtgcaacc                                                                9


<210>  374
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  374
caacaatatt ggaatattcc gacg                                              24


<210>  375
<211>  78
<212>  DNA
<213>  Mus musculus

<400>  375
gacatccagc tgacacaatc ttcatcctcc tattctgtat ctctaggaga cagggtcacc       60

attacttgca aggcaagt                                                     78


<210>  376
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  376
ttagcctggt atcagcagag accaggaaat gctcctaggc tcttaatatc t                51


<210>  377
<211>  108
<212>  DNA
<213>  Mus musculus

<400>  377
agtttggaaa ctgggattcc ttcaagattc agtggcagtg gatctggaaa ggagtacact       60

ctcagcattg ccagtcttca gactgaagat tttgttactt attactgt                   108


<210>  378
<211>  31
<212>  DNA
<213>  Mus musculus

<400>  378
ttcggtggag gcaccaggct ggaaatcaaa c                                      31


<210>  379
<211>  355
<212>  DNA
<213>  Mus musculus

<400>  379
gaggtccagc tgcagcagtc tggacctgac ctggtgaagc ctggggcttc agtgaagata       60

tcctgcaagg cttctggtta ctcattcact ggctactaca tgcactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggacgt gttaatcctt acaacggtga tactaattac      180

aaccagaatt tcaaggacaa ggccatatta actgtagaca agtcagccag tacagcctac      240

atggagttcc gcagcctgac atctgaggac tctgcggtct attactgtac aagatcaaac      300

tgggaaaact actttgacta ctggggccaa ggctccactc tcacagtctc ctcag           355


<210>  380
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  380
ggttactcat tcactggcta ctac                                              24


<210>  381
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  381
gttaatcctt acaacggtga tact                                              24


<210>  382
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  382
acaagatcaa actgggaaaa ctactttgac tac                                    33


<210>  383
<211>  75
<212>  DNA
<213>  Mus musculus

<400>  383
gaggtccagc tgcagcagtc tggacctgac ctggtgaagc ctggggcttc agtgaagata       60

tcctgcaagg cttct                                                        75


<210>  384
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  384
atgcactggg tgaagcagag ccatggaaag agccttgagt ggattggacg t                51


<210>  385
<211>  114
<212>  DNA
<213>  Mus musculus

<400>  385
aattacaacc agaatttcaa ggacaaggcc atattaactg tagacaagtc agccagtaca       60

gcctacatgg agttccgcag cctgacatct gaggactctg cggtctatta ctgt            114


<210>  386
<211>  34
<212>  DNA
<213>  Mus musculus

<400>  386
tggggccaag gctccactct cacagtctcc tcag                                   34


<210>  387
<211>  319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  387
gaaaaggttc tcacccagtc tccagcaatc atgtctgcat ctccagggga agaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tacatgcatt ggtaccagca gaagtcaagc      120

acctccccca aactctggat ttatgaaaca tccaaactgg cttttggagt cccaggtcgc      180

ttcagtggca gtggatctgg aaactcttac tctctcacga tcagcagcat ggaggctgaa      240

gatgttgcca cttattactg ttttcagggg agtgggtacc cattcacgtt cggctcgggg      300

acaaagttgg aagtaaaac                                                   319


<210>  388
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  388
tcaagtgtaa gttac                                                        15


<210>  389
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  389
gaaacatcc                                                                9


<210>  390
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  390
tttcagggga gtgggtaccc attcacg                                           27


<210>  391
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  391
gaaaaggttc tcacccagtc tccagcaatc atgtctgcat ctccagggga agaggtcacc       60

atgacctgca gtgccagc                                                     78


<210>  392
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  392
atgcattggt accagcagaa gtcaagcacc tcccccaaac tctggattta t                51


<210>  393
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  393
aaactggctt ttggagtccc aggtcgcttc agtggcagtg gatctggaaa ctcttactct       60

ctcacgatca gcagcatgga ggctgaagat gttgccactt attactgt                   108


<210>  394
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  394
ttcggctcgg ggacaaagtt ggaagtaaaa c                                      31


<210>  395
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  395
gaaaatgtgc tcacccagtc tccagcaata atggctgcct ctctggggca gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tccagttact tgcactggta ccagcagaag      120

tcaggcgctt cccccaaacc cttgattcat aggacatcca ccctggcttc tggcgtccca      180

gctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag cagcgtggag      240

gctgaagatg atgcaactta ttactgccag cagtggagtg gttacccgta cacgttcgga      300

ggggggacca agctggaaat aaaac                                            325


<210>  396
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  396
tcaagtgtaa gttccagtta c                                                 21


<210>  397
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  397
aggacatcc                                                                9


<210>  398
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  398
cagcagtgga gtggttaccc gtacacg                                           27


<210>  399
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  399
gaaaatgtgc tcacccagtc tccagcaata atggctgcct ctctggggca gaaggtcacc       60

atgacctgca gtgccagc                                                     78


<210>  400
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  400
ttgcactggt accagcagaa gtcaggcgct tcccccaaac ccttgattca t                51


<210>  401
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  401
accctggctt ctggcgtccc agctcgcttc agtggcagtg ggtctgggac ctcttactct       60

ctcacaatca gcagcgtgga ggctgaagat gatgcaactt attactgc                   108


<210>  402
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  402
ttcggagggg ggaccaagct ggaaataaaa c                                      31


<210>  403
<211>  358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  403
gatgtgcagc ttcaggagtc aggacctggc ctggtgaaac cttctcagtc tctgtccctc       60

acctgcactg tcactggcta ctcaatcacc agtgattctg cctggaactg gattcggcag      120

tttccaggaa acaacctgga gtggatgggc tacataagct acagtggtag cactagctac      180

aacccatctc tcaaaagtcg aatctctatc actcgagaca catccaagaa ccagttcttc      240

ctgcagttga actctgtgac tactgaggac acagccacat attactgtgc aagaaggagt      300

agggtctcat tctactttga ctactggggc caaggcacca ctctcacagt ctcctcag        358


<210>  404
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  404
ggctactcaa tcaccagtga ttctgcc                                           27


<210>  405
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  405
ataagctaca gtggtagcac t                                                 21


<210>  406
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  406
gcaagaagga gtagggtctc attctacttt gactac                                 36


<210>  407
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  407
gatgtgcagc ttcaggagtc aggacctggc ctggtgaaac cttctcagtc tctgtccctc       60

acctgcactg tcact                                                        75


<210>  408
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  408
tggaactgga ttcggcagtt tccaggaaac aacctggagt ggatgggcta c                51


<210>  409
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  409
agctacaacc catctctcaa aagtcgaatc tctatcactc gagacacatc caagaaccag       60

ttcttcctgc agttgaactc tgtgactact gaggacacag ccacatatta ctgt            114


<210>  410
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  410
tggggccaag gcaccactct cacagtctcc tcag                                   34


<210>  411
<211>  319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  411
gaaaatgttc tcacccagtc tccaacaatc atgtctgcat ctccagggga agaggtcacc       60

atgacctgca gtgccagctc aagtgtaact tacatgcact ggtaccagca gaagtcaatc      120

acctccccca aactctggat ttatgaaaca tccaaactgg cttctggagt cccaggtcgc      180

ttcagtggca gtgggtctgg aaactcttac tctctcacga tcagcagcat ggaggctgaa      240

gatgttgcca cttattactg ttttcagggg agtgggtacc cattcacgtt cggctcgggg      300

acaaagttgg aaataaaac                                                   319


<210>  412
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  412
tcaagtgtaa cttac                                                        15


<210>  413
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  413
gaaacatcc                                                                9


<210>  414
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  414
tttcagggga gtgggtaccc attcacg                                           27


<210>  415
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  415
gaaaatgttc tcacccagtc tccaacaatc atgtctgcat ctccagggga agaggtcacc       60

atgacctgca gtgccagc                                                     78


<210>  416
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  416
atgcactggt accagcagaa gtcaatcacc tcccccaaac tctggattta t                51


<210>  417
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  417
aaactggctt ctggagtccc aggtcgcttc agtggcagtg ggtctggaaa ctcttactct       60

ctcacgatca gcagcatgga ggctgaagat gttgccactt attactgt                   108


<210>  418
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  418
ttcggctcgg ggacaaagtt ggaaataaaa c                                      31


<210>  419
<211>  352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  419
gaggtccagc tgctacagtc tggccctgag ctggtgaagc ctgggacttc agtgaagata       60

tcctgcaagg cttctggtta ctcattcact ggctactaca ttcactgggt gaagcagacc      120

catgtaaaga gccttgagtg ggttggacgt atttttcctt acaatggtgc tgcaagctac      180

aaccagaatt tcaagggcaa ggccaccttg actgtagata agtcctccac cacagcctac      240

atggagctcc acagcctgac atctgaggac tctgcagtct atttctgtgc aagatggtta      300

agggtctact ttgactactg gggccaaggc accactctca cagtctcctc ag              352


<210>  420
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  420
ggttactcat tcactggcta ctac                                              24


<210>  421
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  421
atttttcctt acaatggtgc tgca                                              24


<210>  422
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  422
gcaagatggt taagggtcta ctttgactac                                        30


<210>  423
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  423
gaggtccagc tgctacagtc tggccctgag ctggtgaagc ctgggacttc agtgaagata       60

tcctgcaagg cttct                                                        75


<210>  424
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  424
attcactggg tgaagcagac ccatgtaaag agccttgagt gggttggacg t                51


<210>  425
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  425
agctacaacc agaatttcaa gggcaaggcc accttgactg tagataagtc ctccaccaca       60

gcctacatgg agctccacag cctgacatct gaggactctg cagtctattt ctgt            114


<210>  426
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  426
tggggccaag gcaccactct cacagtctcc tcag                                   34


<210>  427
<211>  319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  427
gaaattgttc tcacccagtc tccagcaatc atgtctacat ctccagggga aaaggtcacc       60

atgtcctgca gtgccagctc aagtgtaact tacatgcact ggtaccagca gaagtcaatc      120

acctccccca aactctggat ttatgaaaca tccaaactgg cttctggagt ccccggtcgc      180

ttcagtggca gtgggtctgg aaactcttac tctctcacga tcagcagcat ggaggctgaa      240

gatgttgcca cttattactg ttttcagggg agtgggtacc cattcacgtt cggctcgggg      300

acaaagttgg aaataaaac                                                   319


<210>  428
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  428
tcaagtgtaa cttac                                                        15


<210>  429
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  429
gaaacatcc                                                                9


<210>  430
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  430
tttcagggga gtgggtaccc attcacg                                           27


<210>  431
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  431
gaaattgttc tcacccagtc tccagcaatc atgtctacat ctccagggga aaaggtcacc       60

atgtcctgca gtgccagc                                                     78


<210>  432
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  432
atgcactggt accagcagaa gtcaatcacc tcccccaaac tctggattta t                51


<210>  433
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  433
aaactggctt ctggagtccc cggtcgcttc agtggcagtg ggtctggaaa ctcttactct       60

ctcacgatca gcagcatgga ggctgaagat gttgccactt attactgt                   108


<210>  434
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  434
ttcggctcgg ggacaaagtt ggaaataaaa c                                      31


<210>  435
<211>  352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  435
gaggtccagc tgctacagtc tggccctgag ctggtgaagc ctgggacttc agtgaagata       60

tcctgcaagg cttctggtta ctcattcact ggctactaca tacactgggt gaagcagacc      120

catgtaaaga gccttgagtg ggttggacgt atttttcctt acaatggtgc tgctagctac      180

aatcagaatt tcaagggcaa ggccaccttg actgtagata agtcctccag cacagcctac      240

atggagctcc acagcctgac atctgaggac tctgcagtct atttctgtgc aagatggtta      300

agggtctact ttgactactg gggccaaggc accactctca cagtctcctc ag              352


<210>  436
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  436
ggttactcat tcactggcta ctac                                              24


<210>  437
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  437
atttttcctt acaatggtgc tgct                                              24


<210>  438
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  438
gcaagatggt taagggtcta ctttgactac                                        30


<210>  439
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  439
gaggtccagc tgctacagtc tggccctgag ctggtgaagc ctgggacttc agtgaagata       60

tcctgcaagg cttct                                                        75


<210>  440
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  440
atacactggg tgaagcagac ccatgtaaag agccttgagt gggttggacg t                51


<210>  441
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  441
agctacaatc agaatttcaa gggcaaggcc accttgactg tagataagtc ctccagcaca       60

gcctacatgg agctccacag cctgacatct gaggactctg cagtctattt ctgt            114


<210>  442
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  442
tggggccaag gcaccactct cacagtctcc tcag                                   34


<210>  443
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  443
gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc       60

atcacctgct ccgcctcctc ctccgtgtcc tcctcctacc tgcactggta ccagcagaag      120

cccggcaagg cccccaagct gctgatctac cgcacctcca ccctggcctc cggcgtgccc      180

tcccgcttct ccggctccgg ctccggcacc gacttcacct tcaccatctc ctccctgcag      240

cccgaggaca tcgccaccta ctactgccag cagtggtccg gctaccccta caccttcggc      300

cagggcacca aggtggagat caagc                                            325


<210>  444
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  444
tcctccgtgt cctcctccta c                                                 21


<210>  445
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  445
cgcacctcc                                                                9


<210>  446
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  446
cagcagtggt ccggctaccc ctacacc                                           27


<210>  447
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  447
gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc       60

atcacctgct ccgcctcc                                                     78


<210>  448
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  448
ctgcactggt accagcagaa gcccggcaag gcccccaagc tgctgatcta c                51


<210>  449
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  449
accctggcct ccggcgtgcc ctcccgcttc tccggctccg gctccggcac cgacttcacc       60

ttcaccatct cctccctgca gcccgaggac atcgccacct actactgc                   108


<210>  450
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  450
ttcggccagg gcaccaaggt ggagatcaag c                                      31


<210>  451
<211>  358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  451
caggtgcagc tgcaggagtc cggccccggc ctggtgaagc cctcccagac cctgtccctg       60

acctgcaccg tgtccggcgg ctccatctcc tccgactccg cctggaactg gatccgccag      120

ccccccggca agggcctgga gtggatcggc tacatctcct actccggctc cacctcctac      180

aacccctccc tgaagtcccg cgtgaccatg tccgtggaca cctccaagaa ccagttctcc      240

ctgaaggtga actccgtgac cgccgccgac accgccgtgt actactgcgc ccgccgctcc      300

cgcgtgtcct tctacttcga ctactggggc cagggcaccc tggtgaccgt gtcctccg        358


<210>  452
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  452
ggcggctcca tctcctccga ctccgcc                                           27


<210>  453
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  453
atctcctact ccggctccac c                                                 21


<210>  454
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  454
gcccgccgct cccgcgtgtc cttctacttc gactac                                 36


<210>  455
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  455
caggtgcagc tgcaggagtc cggccccggc ctggtgaagc cctcccagac cctgtccctg       60

acctgcaccg tgtcc                                                        75


<210>  456
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  456
tggaactgga tccgccagcc ccccggcaag ggcctggagt ggatcggcta c                51


<210>  457
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  457
tcctacaacc cctccctgaa gtcccgcgtg accatgtccg tggacacctc caagaaccag       60

ttctccctga aggtgaactc cgtgaccgcc gccgacaccg ccgtgtacta ctgc            114


<210>  458
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  458
tggggccagg gcaccctggt gaccgtgtcc tccg                                   34


<210>  459
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  459
gagaacgtgc tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc       60

atgacctgct ccgcctcctc ctccgtgtcc tcctcctacc tgcactggta ccagcagaag      120

cccggcaagt cccccaagcc cctgatccac cgcacctcca ccctggcctc cggcgtgccc      180

tcccgcttct ccggctccgg ctccggcacc tcctactccc tgaccatctc ctccctgcag      240

cccgaggaca tcgccaccta ctactgccag cagtggtccg gctaccccta caccttcggc      300

ggcggcacca aggtggagat caagc                                            325


<210>  460
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  460
tcctccgtgt cctcctccta c                                                 21


<210>  461
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  461
cgcacctcc                                                                9


<210>  462
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  462
cagcagtggt ccggctaccc ctacacc                                           27


<210>  463
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  463
gagaacgtgc tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc       60

atgacctgct ccgcctcc                                                     78


<210>  464
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  464
ctgcactggt accagcagaa gcccggcaag tcccccaagc ccctgatcca c                51


<210>  465
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  465
accctggcct ccggcgtgcc ctcccgcttc tccggctccg gctccggcac ctcctactcc       60

ctgaccatct cctccctgca gcccgaggac atcgccacct actactgc                   108


<210>  466
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  466
ttcggcggcg gcaccaaggt ggagatcaag c                                      31


<210>  467
<211>  358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  467
caggtgcagc tgcaggagtc cggccccggc ctggtgaagc cctcccagac cctgtccctg       60

acctgcaccg tgaccggcta ctccatcacc tccgactccg cctggaactg gatccgccag      120

ttccccggca acaacctgga gtggatgggc tacatctcct actccggctc cacctcctac      180

aacccctccc tgaagtcccg catctccatc acccgcgaca cctccaagaa ccagttctcc      240

ctgaaggtga actccgtgac cgccgccgac accgccgtgt actactgcgc ccgccgctcc      300

cgcgtgtcct tctacttcga ctactggggc cagggcaccc tggtgaccgt gtcctccg        358


<210>  468
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  468
ggctactcca tcacctccga ctccgcc                                           27


<210>  469
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  469
atctcctact ccggctccac c                                                 21


<210>  470
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  470
gcccgccgct cccgcgtgtc cttctacttc gactac                                 36


<210>  471
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  471
caggtgcagc tgcaggagtc cggccccggc ctggtgaagc cctcccagac cctgtccctg       60

acctgcaccg tgacc                                                        75


<210>  472
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  472
tggaactgga tccgccagtt ccccggcaac aacctggagt ggatgggcta c                51


<210>  473
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  473
tcctacaacc cctccctgaa gtcccgcatc tccatcaccc gcgacacctc caagaaccag       60

ttctccctga aggtgaactc cgtgaccgcc gccgacaccg ccgtgtacta ctgc            114


<210>  474
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  474
tggggccagg gcaccctggt gaccgtgtcc tccg                                   34


<210>  475
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  475
gagaacgtgc tgacccagtc cccctcctcc atgtccgcct ccgtgggcga ccgcgtgacc       60

atgacctgct ccgcctcctc ctccgtgtcc tcctcctacc tgcactggta ccagcagaag      120

cccggcaagg cccccaagcc cctgatccac cgcacctcca ccctggcctc cggcgtgccc      180

tcccgcttct ccggctccgg ctccggcacc tcctactccc tgaccatctc ctccgtgcag      240

cccgaggaca tcgccaccta ctactgccag cagtggtccg gctaccccta caccttcggc      300

ggcggcacca aggtggagat caagc                                            325


<210>  476
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  476
tcctccgtgt cctcctccta c                                                 21


<210>  477
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  477
cgcacctcc                                                                9


<210>  478
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  478
cagcagtggt ccggctaccc ctacacc                                           27


<210>  479
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  479
gagaacgtgc tgacccagtc cccctcctcc atgtccgcct ccgtgggcga ccgcgtgacc       60

atgacctgct ccgcctcc                                                     78


<210>  480
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  480
ctgcactggt accagcagaa gcccggcaag gcccccaagc ccctgatcca c                51


<210>  481
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  481
accctggcct ccggcgtgcc ctcccgcttc tccggctccg gctccggcac ctcctactcc       60

ctgaccatct cctccgtgca gcccgaggac atcgccacct actactgc                   108


<210>  482
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  482
ttcggcggcg gcaccaaggt ggagatcaag c                                      31


<210>  483
<211>  358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  483
caggtgcagc tgcaggagtc cggccccggc ctggtgaagc cctcccagac cctgtccctg       60

acctgcaccg tgaccggcta ctccatcacc tccgactccg cctggaactg gatccgccag      120

ccccccggca acggcctgga gtggatgggc tacatctcct actccggctc cacctcctac      180

aacccctccc tgaagtcccg catctccatc acccgcgaca cctccaagaa ccagttctcc      240

ctgaagctga actccgtgac cgccgccgac accgccacct actactgcgc ccgccgctcc      300

cgcgtgtcct tctacttcga ctactggggc cagggcaccc tggtgaccgt gtcctccg        358


<210>  484
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  484
ggctactcca tcacctccga ctccgcc                                           27


<210>  485
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  485
atctcctact ccggctccac c                                                 21


<210>  486
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  486
gcccgccgct cccgcgtgtc cttctacttc gactac                                 36


<210>  487
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  487
caggtgcagc tgcaggagtc cggccccggc ctggtgaagc cctcccagac cctgtccctg       60

acctgcaccg tgacc                                                        75


<210>  488
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  488
tggaactgga tccgccagcc ccccggcaac ggcctggagt ggatgggcta c                51


<210>  489
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  489
tcctacaacc cctccctgaa gtcccgcatc tccatcaccc gcgacacctc caagaaccag       60

ttctccctga agctgaactc cgtgaccgcc gccgacaccg ccacctacta ctgc            114


<210>  490
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  490
tggggccagg gcaccctggt gaccgtgtcc tccg                                   34


<210>  491
<211>  319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  491
gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc       60

atcacctgct ccgcctcctc ctccgtgacc tacatgcact ggtaccagca gaagcccggc      120

aaggccccca agctgctgat ctacgagacc tccaagctgg cctccggcgt gccctcccgc      180

ttctccggct ccggctccgg caccgactac accttcacca tctcctccct gcagcccgag      240

gacatcgcca cctactactg cttccagggc tccggctacc ccttcacctt cggccagggc      300

accaaggtgg agatcaagc                                                   319


<210>  492
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  492
tcctccgtga cctac                                                        15


<210>  493
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  493
gagacctcc                                                                9


<210>  494
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  494
ttccagggct ccggctaccc cttcacc                                           27


<210>  495
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  495
gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc       60

atcacctgct ccgcctcc                                                     78


<210>  496
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  496
atgcactggt accagcagaa gcccggcaag gcccccaagc tgctgatcta c                51


<210>  497
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  497
aagctggcct ccggcgtgcc ctcccgcttc tccggctccg gctccggcac cgactacacc       60

ttcaccatct cctccctgca gcccgaggac atcgccacct actactgc                   108


<210>  498
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  498
ttcggccagg gcaccaaggt ggagatcaag c                                      31


<210>  499
<211>  352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  499
caggtgcagc tggtgcagtc cggcgccgag gtgaagaagc ccggcgagtc cgtgaaggtg       60

tcctgcaagg cctccggcta caccttcacc ggctactaca tccactgggt gcgccaggcc      120

cccggccagg gcctggagtg gatgggccgc atcttcccct acaacggcgc cgcctcctac      180

aaccagaact tcaagggccg cgtgaccatc accgccgaca agtccacctc caccgcctac      240

atggagctgt cctccctgcg ctccgaggac accgccgtgt actactgcgc ccgctggctg      300

cgcgtgtact tcgactactg gggccagggc accaccgtga ccgtgtcctc cg              352


<210>  500
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  500
ggctacacct tcaccggcta ctac                                              24


<210>  501
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  501
atcttcccct acaacggcgc cgcc                                              24


<210>  502
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  502
gcccgctggc tgcgcgtgta cttcgactac                                        30


<210>  503
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  503
caggtgcagc tggtgcagtc cggcgccgag gtgaagaagc ccggcgagtc cgtgaaggtg       60

tcctgcaagg cctcc                                                        75


<210>  504
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  504
atccactggg tgcgccaggc ccccggccag ggcctggagt ggatgggccg c                51


<210>  505
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  505
tcctacaacc agaacttcaa gggccgcgtg accatcaccg ccgacaagtc cacctccacc       60

gcctacatgg agctgtcctc cctgcgctcc gaggacaccg ccgtgtacta ctgc            114


<210>  506
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  506
tggggccagg gcaccaccgt gaccgtgtcc tccg                                   34


<210>  507
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  507
gagaacgtgc tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc       60

atcacctgct ccgcctcctc ctccgtgacc tacatgcact ggtaccagca gaagcccggc      120

aaggccccca agctgtggat ctacgagacc tccaagctgg cctccggcgt gcccggccgc      180

ttctccggct ccggctccgg caactcctac accttcacca tctcctccct gcagcccgag      240

gacatcgcca cctactactg cttccagggc tccggctacc ccttcacctt cggccagggc      300

accaaggtgg agatcaag                                                    318


<210>  508
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  508
tcctccgtga cctac                                                        15


<210>  509
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  509
gagacctcc                                                                9


<210>  510
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  510
ttccagggct ccggctaccc cttcacc                                           27


<210>  511
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  511
gagaacgtgc tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc       60

atcacctgct ccgcctcc                                                     78


<210>  512
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  512
atgcactggt accagcagaa gcccggcaag gcccccaagc tgtggatcta c                51


<210>  513
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  513
aagctggcct ccggcgtgcc cggccgcttc tccggctccg gctccggcaa ctcctacacc       60

ttcaccatct cctccctgca gcccgaggac atcgccacct actactgc                   108


<210>  514
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  514
ttcggccagg gcaccaaggt ggagatcaag                                        30


<210>  515
<211>  352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  515
gaggtgcagc tggtgcagtc cggcgccgag gtgaagaagc ccggcgagtc cgtgaaggtg       60

tcctgcaagg cctccggcta ctccttcacc ggctactaca tccactgggt gaagcaggcc      120

cccggccagg gcctggagtg ggtgggccgc atcttcccct acaacggcgc cgcctcctac      180

aaccagaact tcaagggcaa ggccaccctg accgtggaca agtcctccac caccgcctac      240

atggagctgt cctccctgcg ctccgaggac accgccgtgt acttctgcgc ccgctggctg      300

cgcgtgtact tcgactactg gggccagggc accaccgtga ccgtgtcctc cg              352


<210>  516
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  516
ggctactcct tcaccggcta ctac                                              24


<210>  517
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  517
atcttcccct acaacggcgc cgcc                                              24


<210>  518
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  518
gcccgctggc tgcgcgtgta cttcgactac                                        30


<210>  519
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  519
gaggtgcagc tggtgcagtc cggcgccgag gtgaagaagc ccggcgagtc cgtgaaggtg       60

tcctgcaagg cctcc                                                        75


<210>  520
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  520
atccactggg tgaagcaggc ccccggccag ggcctggagt gggtgggccg c                51


<210>  521
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  521
tcctacaacc agaacttcaa gggcaaggcc accctgaccg tggacaagtc ctccaccacc       60

gcctacatgg agctgtcctc cctgcgctcc gaggacaccg ccgtgtactt ctgc            114


<210>  522
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  522
tggggccagg gcaccaccgt gaccgtgtcc tccg                                   34


<210>  523
<211>  319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  523
gagaacgtgc tgacccagtc cccctcctcc atgtccgcct ccgtgggcga ccgcgtgacc       60

atgacctgct ccgcctcctc ctccgtgacc tacatgcact ggtaccagca gaagcccggc      120

aagtccccca agctgtggat ctacgagacc tccaagctgg cctccggcgt gccctcccgc      180

ttctccggct ccggctccgg caacgactac tccctgacca tctcctccat gcagcccgag      240

gacgtggcca cctactactg cttccagggc tccggctacc ccttcacctt cggccagggc      300

accaagctgg agatcaagc                                                   319


<210>  524
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  524
tcctccgtga cctac                                                        15


<210>  525
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  525
gagacctcc                                                                9


<210>  526
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  526
ttccagggct ccggctaccc cttcacc                                           27


<210>  527
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  527
gagaacgtgc tgacccagtc cccctcctcc atgtccgcct ccgtgggcga ccgcgtgacc       60

atgacctgct ccgcctcc                                                     78


<210>  528
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  528
atgcactggt accagcagaa gcccggcaag tcccccaagc tgtggatcta c                51


<210>  529
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  529
aagctggcct ccggcgtgcc ctcccgcttc tccggctccg gctccggcaa cgactactcc       60

ctgaccatct cctccatgca gcccgaggac gtggccacct actactgc                   108


<210>  530
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  530
ttcggccagg gcaccaagct ggagatcaag c                                      31


<210>  531
<211>  352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  531
gaggtgcagc tggtgcagtc cggcgccgag gtggtgaagc ccggcgagtc cgtgaagatc       60

tcctgcaagg cctccggcta ctccttcacc ggctactaca tccactgggt gaagcagacc      120

cccggccagt ccctggagtg ggtgggccgc atcttcccct acaacggcgc cgcctcctac      180

aaccagaact tcaagggcaa ggccaccctg accgtggaca agtccaccac caccgcctac      240

atggagctgt cctccctgcg ctccgaggac tccgccgtgt acttctgcgc ccgctggctg      300

cgcgtgtact tcgactactg gggccagggc accaccctga ccgtgtcctc cg              352


<210>  532
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  532
ggctactcct tcaccggcta ctac                                              24


<210>  533
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  533
atcttcccct acaacggcgc cgcc                                              24


<210>  534
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  534
gcccgctggc tgcgcgtgta cttcgactac                                        30


<210>  535
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  535
gaggtgcagc tggtgcagtc cggcgccgag gtggtgaagc ccggcgagtc cgtgaagatc       60

tcctgcaagg cctcc                                                        75


<210>  536
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  536
atccactggg tgaagcagac ccccggccag tccctggagt gggtgggccg c                51


<210>  537
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  537
tcctacaacc agaacttcaa gggcaaggcc accctgaccg tggacaagtc caccaccacc       60

gcctacatgg agctgtcctc cctgcgctcc gaggactccg ccgtgtactt ctgc            114


<210>  538
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  538
tggggccagg gcaccaccct gaccgtgtcc tccg                                   34


<210>  539
<211>  319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  539
gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc       60

atcacctgct ccgcctcctc ctccgtgacc tacatgcact ggtaccagca gaagcccggc      120

aaggccccca agctgctgat ctacgagacc tccaagctgg cctccggcgt gccctcccgc      180

ttctccggct ccggctccgg caccgactac accttcacca tctcctccct gcagcccgag      240

gacatcgcca cctactactg cttccagggc tccggctacc ccttcacctt cggccagggc      300

accaaggtgg agatcaagc                                                   319


<210>  540
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  540
tcctccgtga cctac                                                        15


<210>  541
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  541
gagacctcc                                                                9


<210>  542
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  542
ttccagggct ccggctaccc cttcacc                                           27


<210>  543
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  543
gacatccaga tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc       60

atcacctgct ccgcctcc                                                     78


<210>  544
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  544
atgcactggt accagcagaa gcccggcaag gcccccaagc tgctgatcta c                51


<210>  545
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  545
aagctggcct ccggcgtgcc ctcccgcttc tccggctccg gctccggcac cgactacacc       60

ttcaccatct cctccctgca gcccgaggac atcgccacct actactgc                   108


<210>  546
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  546
ttcggccagg gcaccaaggt ggagatcaag c                                      31


<210>  547
<211>  352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  547
caggtgcagc tggtgcagtc cggcgccgag gtgaagaagc ccggcgagtc cgtgaaggtg       60

tcctgcaagg cctccggcta caccttcacc ggctactaca tccactgggt gcgccaggcc      120

cccggccagg gcctggagtg gatgggccgc atcttcccct acaacggcgc cgcctcctac      180

aaccagaact tcaagggccg cgtgaccatc accgccgaca agtccacctc caccgcctac      240

atggagctgt cctccctgcg ctccgaggac accgccgtgt actactgcgc ccgctggctg      300

cgcgtgtact tcgactactg gggccagggc accaccgtga ccgtgtcctc cg              352


<210>  548
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  548
ggctacacct tcaccggcta ctac                                              24


<210>  549
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  549
atcttcccct acaacggcgc cgcc                                              24


<210>  550
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  550
gcccgctggc tgcgcgtgta cttcgactac                                        30


<210>  551
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  551
caggtgcagc tggtgcagtc cggcgccgag gtgaagaagc ccggcgagtc cgtgaaggtg       60

tcctgcaagg cctcc                                                        75


<210>  552
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  552
atccactggg tgcgccaggc ccccggccag ggcctggagt ggatgggccg c                51


<210>  553
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  553
tcctacaacc agaacttcaa gggccgcgtg accatcaccg ccgacaagtc cacctccacc       60

gcctacatgg agctgtcctc cctgcgctcc gaggacaccg ccgtgtacta ctgc            114


<210>  554
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  554
tggggccagg gcaccaccgt gaccgtgtcc tccg                                   34


<210>  555
<211>  319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  555
gagatcgtgc tgacccagtc cccctcctcc ctgtccacct ccgtgggcga ccgcgtgacc       60

atctcctgct ccgcctcctc ctccgtgacc tacatgcact ggtaccagca gaagcccggc      120

aaggccccca agctgtggat ctacgagacc tccaagctgg cctccggcgt gcccggccgc      180

ttctccggct ccggctccgg caactcctac accttcacca tctcctccct gcagcccgag      240

gacatcgcca cctactactg cttccagggc tccggctacc ccttcacctt cggccagggc      300

accaaggtgg agatcaagc                                                   319


<210>  556
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  556
tcctccgtga cctac                                                        15


<210>  557
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  557
gagacctcc                                                                9


<210>  558
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  558
ttccagggct ccggctaccc cttcacc                                           27


<210>  559
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  559
gagatcgtgc tgacccagtc cccctcctcc ctgtccacct ccgtgggcga ccgcgtgacc       60

atctcctgct ccgcctcc                                                     78


<210>  560
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  560
atgcactggt accagcagaa gcccggcaag gcccccaagc tgtggatcta c                51


<210>  561
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  561
aagctggcct ccggcgtgcc cggccgcttc tccggctccg gctccggcaa ctcctacacc       60

ttcaccatct cctccctgca gcccgaggac atcgccacct actactgc                   108


<210>  562
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  562
ttcggccagg gcaccaaggt ggagatcaag c                                      31


<210>  563
<211>  352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  563
gaggtgcagc tggtgcagtc cggcgccgag gtgaagaagc ccggcgagtc cgtgaaggtg       60

tcctgcaagg cctccggcta ctccttcacc ggctactaca tccactgggt gaagcaggcc      120

cccggccagg gcctggagtg ggtgggccgc atcttcccct acaacggcgc cgcctcctac      180

aaccagaact tcaagggcaa ggccaccctg accgtggaca agtcctcctc caccgcctac      240

atggagctgt cctccctgcg ctccgaggac accgccgtgt acttctgcgc ccgctggctg      300

cgcgtgtact tcgactactg gggccagggc accaccgtga ccgtgtcctc cg              352


<210>  564
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  564
ggctactcct tcaccggcta ctac                                              24


<210>  565
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  565
atcttcccct acaacggcgc cgcc                                              24


<210>  566
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  566
gcccgctggc tgcgcgtgta cttcgactac                                        30


<210>  567
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  567
gaggtgcagc tggtgcagtc cggcgccgag gtgaagaagc ccggcgagtc cgtgaaggtg       60

tcctgcaagg cctcc                                                        75


<210>  568
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  568
atccactggg tgaagcaggc ccccggccag ggcctggagt gggtgggccg c                51


<210>  569
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  569
tcctacaacc agaacttcaa gggcaaggcc accctgaccg tggacaagtc ctcctccacc       60

gcctacatgg agctgtcctc cctgcgctcc gaggacaccg ccgtgtactt ctgc            114


<210>  570
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  570
tggggccagg gcaccaccgt gaccgtgtcc tccg                                   34


<210>  571
<211>  319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  571
gagatcgtgc tgacccagtc cccctcctcc atgtccacct ccgtgggcga ccgcgtgacc       60

atgtcctgct ccgcctcctc ctccgtgacc tacatgcact ggtaccagca gaagcccggc      120

aagtccccca agctgtggat ctacgagacc tccaagctgg cctccggcgt gccctcccgc      180

ttctccggct ccggctccgg caacgactac tccctgacca tctcctccat gcagcccgag      240

gacgtggcca cctactactg cttccagggc tccggctacc ccttcacctt cggccagggc      300

accaagctgg agatcaagc                                                   319


<210>  572
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  572
tcctccgtga cctac                                                        15


<210>  573
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  573
gagacctcc                                                                9


<210>  574
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  574
ttccagggct ccggctaccc cttcacc                                           27


<210>  575
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  575
gagatcgtgc tgacccagtc cccctcctcc atgtccacct ccgtgggcga ccgcgtgacc       60

atgtcctgct ccgcctcc                                                     78


<210>  576
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  576
atgcactggt accagcagaa gcccggcaag tcccccaagc tgtggatcta c                51


<210>  577
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  577
aagctggcct ccggcgtgcc ctcccgcttc tccggctccg gctccggcaa cgactactcc       60

ctgaccatct cctccatgca gcccgaggac gtggccacct actactgc                   108


<210>  578
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  578
ttcggccagg gcaccaagct ggagatcaag c                                      31


<210>  579
<211>  352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  579
gaggtgcagc tggtgcagtc cggcgccgag gtggtgaagc ccggcgagtc cgtgaagatc       60

tcctgcaagg cctccggcta ctccttcacc ggctactaca tccactgggt gaagcagacc      120

cccggccagt ccctggagtg ggtgggccgc atcttcccct acaacggcgc cgcctcctac      180

aaccagaact tcaagggcaa ggccaccctg accgtggaca agtccacctc caccgcctac      240

atggagctgt cctccctgcg ctccgaggac tccgccgtgt acttctgcgc ccgctggctg      300

cgcgtgtact tcgactactg gggccagggc accaccctga ccgtgtcctc cg              352


<210>  580
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  580
ggctactcct tcaccggcta ctac                                              24


<210>  581
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  581
atcttcccct acaacggcgc cgcc                                              24


<210>  582
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  582
gcccgctggc tgcgcgtgta cttcgactac                                        30


<210>  583
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  583
gaggtgcagc tggtgcagtc cggcgccgag gtggtgaagc ccggcgagtc cgtgaagatc       60

tcctgcaagg cctcc                                                        75


<210>  584
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  584
atccactggg tgaagcagac ccccggccag tccctggagt gggtgggccg c                51


<210>  585
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  585
tcctacaacc agaacttcaa gggcaaggcc accctgaccg tggacaagtc cacctccacc       60

gcctacatgg agctgtcctc cctgcgctcc gaggactccg ccgtgtactt ctgc            114


<210>  586
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  586
tggggccagg gcaccaccct gaccgtgtcc tccg                                   34


<210>  587
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  587
gacattcaga tgactcagtc tccctcctcc ctgtctgctt ccgtggggga ccgcgtcact       60

attacctgtt ccgcttcctc ctccgtcagc tcctcttacc tgcactggta tcagcagaag      120

ccaggaaaag cccccaagct gctgatctac cggacctcca cactggcttc tggcgtgccc      180

agtagattct ctggcagtgg gtcaggaaca gacttcactt ttaccatcag ttcactgcag      240

cctgaggata ttgccactta ctattgccag cagtggagcg gctacccata tacctttggc      300

caggggacaa aagtggagat caaga                                            325


<210>  588
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  588
tcctccgtca gctcctctta c                                                 21


<210>  589
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  589
cggacctcc                                                                9


<210>  590
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  590
cagcagtgga gcggctaccc atatacc                                           27


<210>  591
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  591
gacattcaga tgactcagtc tccctcctcc ctgtctgctt ccgtggggga ccgcgtcact       60

attacctgtt ccgcttcc                                                     78


<210>  592
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  592
ctgcactggt atcagcagaa gccaggaaaa gcccccaagc tgctgatcta c                51


<210>  593
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  593
acactggctt ctggcgtgcc cagtagattc tctggcagtg ggtcaggaac agacttcact       60

tttaccatca gttcactgca gcctgaggat attgccactt actattgc                   108


<210>  594
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  594
tttggccagg ggacaaaagt ggagatcaag a                                      31


<210>  595
<211>  358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  595
caggtgcagc tgcaggaatc tgggcctgga ctggtcaaac cctctcagac tctgtctctg       60

acttgtactg tgtccggggg gagcatcagc tccgatagcg cctggaactg gatcagacag      120

ccccctggga agggactgga gtggatcggg tacattagtt attcaggaag cacctcctac      180

aatccctccc tgaaatctag ggtcactatg tcagtggaca ccagcaagaa ccagttctcc      240

ctgaaagtca attctgtgac tgccgctgat accgccgtgt actattgcgc tcggagaagt      300

agggtgtcat tctactttga ctattggggc caggggaccc tggtcacagt gtctagtg        358


<210>  596
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  596
ggggggagca tcagctccga tagcgcc                                           27


<210>  597
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  597
attagttatt caggaagcac c                                                 21


<210>  598
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  598
gctcggagaa gtagggtgtc attctacttt gactat                                 36


<210>  599
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  599
caggtgcagc tgcaggaatc tgggcctgga ctggtcaaac cctctcagac tctgtctctg       60

acttgtactg tgtcc                                                        75


<210>  600
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  600
tggaactgga tcagacagcc ccctgggaag ggactggagt ggatcgggta c                51


<210>  601
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  601
tcctacaatc cctccctgaa atctagggtc actatgtcag tggacaccag caagaaccag       60

ttctccctga aagtcaattc tgtgactgcc gctgataccg ccgtgtacta ttgc            114


<210>  602
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  602
tggggccagg ggaccctggt cacagtgtct agtg                                   34


<210>  603
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  603
gaaaatgtgc tgactcagtc cccttccagc ctgtccgcaa gcgtcggcga cagggtgact       60

atgacctgca gcgcctctag ttcagtgtcc agctcttacc tgcactggta tcagcagaag      120

cccgggaaat ctcctaagcc actgatccat aggacatcta ctctggctag tggtgtgcct      180

tcacggttct ctggtagtgg ctcaggaaca tcctacagcc tgactatcag ttcactgcag      240

ccagaggaca ttgcaaccta ctattgccag cagtggtctg gataccccta tacctttggc      300

ggagggacaa aagtggagat caagc                                            325


<210>  604
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  604
agttcagtgt ccagctctta c                                                 21


<210>  605
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  605
aggacatct                                                                9


<210>  606
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  606
cagcagtggt ctggataccc ctatacc                                           27


<210>  607
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  607
gaaaatgtgc tgactcagtc cccttccagc ctgtccgcaa gcgtcggcga cagggtgact       60

atgacctgca gcgcctct                                                     78


<210>  608
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  608
ctgcactggt atcagcagaa gcccgggaaa tctcctaagc cactgatcca t                51


<210>  609
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  609
actctggcta gtggtgtgcc ttcacggttc tctggtagtg gctcaggaac atcctacagc       60

ctgactatca gttcactgca gccagaggac attgcaacct actattgc                   108


<210>  610
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  610
tttggcggag ggacaaaagt ggagatcaag c                                      31


<210>  611
<211>  358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  611
caggtccagc tgcaggaatc cgggcctggt ctggtgaagc catctcagac cctgagtctg       60

acttgtaccg tgacagggta cagcatcaca tctgacagtg cctggaactg gattagacag      120

ttccctggta acaatctgga gtggatgggc tacatttcat attccggaag cacctcttat      180

aatcccagtc tgaagtcaag aatctccatt acccgcgaca catcaaaaaa ccagttttcc      240

ctgaaggtca atagcgtgac agctgcagat actgctgtct actattgcgc aaggcggagc      300

cgcgtgtctt tctactttga ctattggggc cagggaactc tggtcaccgt gtcatccg        358


<210>  612
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  612
gggtacagca tcacatctga cagtgcc                                           27


<210>  613
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  613
atttcatatt ccggaagcac c                                                 21


<210>  614
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  614
gcaaggcgga gccgcgtgtc tttctacttt gactat                                 36


<210>  615
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  615
caggtccagc tgcaggaatc cgggcctggt ctggtgaagc catctcagac cctgagtctg       60

acttgtaccg tgaca                                                        75


<210>  616
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  616
tggaactgga ttagacagtt ccctggtaac aatctggagt ggatgggcta c                51


<210>  617
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  617
tcttataatc ccagtctgaa gtcaagaatc tccattaccc gcgacacatc aaaaaaccag       60

ttttccctga aggtcaatag cgtgacagct gcagatactg ctgtctacta ttgc            114


<210>  618
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  618
tggggccagg gaactctggt caccgtgtca tccg                                   34


<210>  619
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  619
gagaacgtcc tgacacagtc cccttccagc atgtccgcaa gcgtcggcga cagggtgact       60

atgacctgct ccgcctctag ttcagtgtcc agctcttacc tgcactggta tcagcagaag      120

ccaggcaaag ctcccaagcc tctgatccat aggacatcta ctctggcaag tggagtgccc      180

tcacggttct ctggtagtgg ctcaggaaca tcctacagcc tgactatcag ttcagtgcag      240

cctgaggaca ttgctaccta ctattgccag cagtggagcg gctacccata tacctttggc      300

ggagggacaa aagtggagat caagc                                            325


<210>  620
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  620
agttcagtgt ccagctctta c                                                 21


<210>  621
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  621
aggacatct                                                                9


<210>  622
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  622
cagcagtgga gcggctaccc atatacc                                           27


<210>  623
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  623
gagaacgtcc tgacacagtc cccttccagc atgtccgcaa gcgtcggcga cagggtgact       60

atgacctgct ccgcctct                                                     78


<210>  624
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  624
ctgcactggt atcagcagaa gccaggcaaa gctcccaagc ctctgatcca t                51


<210>  625
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  625
actctggcaa gtggagtgcc ctcacggttc tctggtagtg gctcaggaac atcctacagc       60

ctgactatca gttcagtgca gcctgaggac attgctacct actattgc                   108


<210>  626
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  626
tttggcggag ggacaaaagt ggagatcaag c                                      31


<210>  627
<211>  358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  627
caggtccagc tgcaggaaag cgggcccggt ctggtgaagc cttctcagac cctgagtctg       60

acttgtaccg tgacaggata ctctatcaca tctgacagtg cctggaactg gattagacag      120

ccacccggca atggactgga gtggatgggg tacatttcat attccggtag cacatcttat      180

aatccaagtc tgaagtcaag aatctccatt actcgcgaca cctcaaaaaa ccagttctcc      240

ctgaagctga atagcgtgac tgctgcagat actgctacct actattgcgc aaggcggagc      300

cgcgtgtctt tctactttga ctattggggg cagggtacac tggtcactgt gtcatccg        358


<210>  628
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  628
ggatactcta tcacatctga cagtgcc                                           27


<210>  629
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  629
atttcatatt ccggtagcac a                                                 21


<210>  630
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  630
gcaaggcgga gccgcgtgtc tttctacttt gactat                                 36


<210>  631
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  631
caggtccagc tgcaggaaag cgggcccggt ctggtgaagc cttctcagac cctgagtctg       60

acttgtaccg tgaca                                                        75


<210>  632
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  632
tggaactgga ttagacagcc acccggcaat ggactggagt ggatggggta c                51


<210>  633
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  633
tcttataatc caagtctgaa gtcaagaatc tccattactc gcgacacctc aaaaaaccag       60

ttctccctga agctgaatag cgtgactgct gcagatactg ctacctacta ttgc            114


<210>  634
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  634
tgggggcagg gtacactggt cactgtgtca tccg                                   34


<210>  635
<211>  319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  635
gatattcaga tgacccagtc cccctcctcc ctgtcagctt ccgtcggcga tagagtcacc       60

attacctgtt ccgctagttc ctccgtcaca tacatgcact ggtatcagca gaagccaggg      120

aaagccccca agctgctgat ctacgagact agtaaactgg cttcaggagt gccaagcagg      180

ttctcaggca gcgggtccgg aactgactat acctttacaa tcagctccct gcagcctgaa      240

gatattgcca cctactattg cttccagggc agcgggtacc cattcacatt tggacagggc      300

actaaagtgg agatcaagc                                                   319


<210>  636
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  636
tcctccgtca catac                                                        15


<210>  637
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  637
gagactagt                                                                9


<210>  638
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  638
ttccagggca gcgggtaccc attcaca                                           27


<210>  639
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  639
gatattcaga tgacccagtc cccctcctcc ctgtcagctt ccgtcggcga tagagtcacc       60

attacctgtt ccgctagt                                                     78


<210>  640
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  640
atgcactggt atcagcagaa gccagggaaa gcccccaagc tgctgatcta c                51


<210>  641
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  641
aaactggctt caggagtgcc aagcaggttc tcaggcagcg ggtccggaac tgactatacc       60

tttacaatca gctccctgca gcctgaagat attgccacct actattgc                   108


<210>  642
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  642
tttggacagg gcactaaagt ggagatcaag c                                      31


<210>  643
<211>  352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  643
caggtgcagc tggtccagtc cggggccgag gtcaaaaagc ctggggagtc cgtcaaagtg       60

tcttgtaaag catctgggta tacatttacc gggtactata tccactgggt gagacaggca      120

cctggacagg gactggagtg gatggggagg attttcccat acaacggagc cgccagctat      180

aaccagaact tcaagggccg cgtgacaatc actgcagaca aaagtacctc aacagcctac      240

atggagctga gctccctgcg aagcgaagac acagccgtct actattgcgc tcggtggctg      300

agagtgtact tcgattattg gggccagggg accacagtca ccgtgtctag tg              352


<210>  644
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  644
gggtatacat ttaccgggta ctat                                              24


<210>  645
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  645
attttcccat acaacggagc cgcc                                              24


<210>  646
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  646
gctcggtggc tgagagtgta cttcgattat                                        30


<210>  647
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  647
caggtgcagc tggtccagtc cggggccgag gtcaaaaagc ctggggagtc cgtcaaagtg       60

tcttgtaaag catct                                                        75


<210>  648
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  648
atccactggg tgagacaggc acctggacag ggactggagt ggatggggag g                51


<210>  649
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  649
agctataacc agaacttcaa gggccgcgtg acaatcactg cagacaaaag tacctcaaca       60

gcctacatgg agctgagctc cctgcgaagc gaagacacag ccgtctacta ttgc            114


<210>  650
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  650
tggggccagg ggaccacagt caccgtgtct agtg                                   34


<210>  651
<211>  319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  651
gagaacgtcc tgacacagtc accttccagc ctgagcgcct ctgtcggtga cagagtgacc       60

atcacatgct ctgcttctag ttcagtgaca tacatgcact ggtatcagca gaagccaggc      120

aaagcaccca agctgtggat ctacgagact tctaagctgg caagtggtgt gccaggacgc      180

ttcagtggat caggatccgg gaactcttat acttttacca tctccagcct gcagccagaa      240

gatattgcta cctactattg cttccagggt tccggctacc ccttcacatt tggacagggg      300

actaaagtgg agatcaaga                                                   319


<210>  652
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  652
agttcagtga catac                                                        15


<210>  653
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  653
gagacttct                                                                9


<210>  654
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  654
ttccagggtt ccggctaccc cttcaca                                           27


<210>  655
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  655
gagaacgtcc tgacacagtc accttccagc ctgagcgcct ctgtcggtga cagagtgacc       60

atcacatgct ctgcttct                                                     78


<210>  656
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  656
atgcactggt atcagcagaa gccaggcaaa gcacccaagc tgtggatcta c                51


<210>  657
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  657
aagctggcaa gtggtgtgcc aggacgcttc agtggatcag gatccgggaa ctcttatact       60

tttaccatct ccagcctgca gccagaagat attgctacct actattgc                   108


<210>  658
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  658
tttggacagg ggactaaagt ggagatcaag a                                      31


<210>  659
<211>  352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  659
gaagtccagc tggtgcagag cggagcagag gtgaagaaac ctggggaaag cgtcaaagtg       60

tcttgtaagg ctagcggata ctctttcacc gggtactata tccactgggt caagcaggca      120

cctggtcagg gactggagtg ggtgggtaga attttcccct acaatggcgc tgcaagctat      180

aaccagaatt ttaagggcaa agcaaccctg acagtggaca agagctctac cacagcctac      240

atggagctga gttcactgcg ctctgaagac accgctgtct atttctgcgc aaggtggctg      300

cgggtgtact ttgattattg gggacagggg actaccgtca ctgtgtccag cg              352


<210>  660
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  660
ggatactctt tcaccgggta ctat                                              24


<210>  661
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  661
attttcccct acaatggcgc tgca                                              24


<210>  662
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  662
gcaaggtggc tgcgggtgta ctttgattat                                        30


<210>  663
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  663
gaagtccagc tggtgcagag cggagcagag gtgaagaaac ctggggaaag cgtcaaagtg       60

tcttgtaagg ctagc                                                        75


<210>  664
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  664
atccactggg tcaagcaggc acctggtcag ggactggagt gggtgggtag a                51


<210>  665
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  665
agctataacc agaattttaa gggcaaagca accctgacag tggacaagag ctctaccaca       60

gcctacatgg agctgagttc actgcgctct gaagacaccg ctgtctattt ctgc            114


<210>  666
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  666
tggggacagg ggactaccgt cactgtgtcc agcg                                   34


<210>  667
<211>  319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  667
gagaacgtcc tgacacagag tccttccagc atgtcagcct ccgtcggaga cagagtgaca       60

atgacttgct ctgcttctag ttcagtgaca tacatgcact ggtatcagca gaagccaggg      120

aaatccccca agctgtggat ctacgagact tctaagctgg caagtggtgt gccctcacgc      180

ttcagcggct ctggaagtgg gaacgactat agcctgacaa tttccagcat gcagccagaa      240

gatgtggcca cttactattg ctttcagggt tctggctacc ccttcacctt tggacagggg      300

acaaaactgg agatcaaga                                                   319


<210>  668
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  668
agttcagtga catac                                                        15


<210>  669
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  669
gagacttct                                                                9


<210>  670
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  670
tttcagggtt ctggctaccc cttcacc                                           27


<210>  671
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  671
gagaacgtcc tgacacagag tccttccagc atgtcagcct ccgtcggaga cagagtgaca       60

atgacttgct ctgcttct                                                     78


<210>  672
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  672
atgcactggt atcagcagaa gccagggaaa tcccccaagc tgtggatcta c                51


<210>  673
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  673
aagctggcaa gtggtgtgcc ctcacgcttc agcggctctg gaagtgggaa cgactatagc       60

ctgacaattt ccagcatgca gccagaagat gtggccactt actattgc                   108


<210>  674
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  674
tttggacagg ggacaaaact ggagatcaag a                                      31


<210>  675
<211>  352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  675
gaagtccagc tggtgcagtc cggagcagag gtggtcaaac ctggggaatc tgtgaaaatc       60

agttgtaagg cctcaggata ctccttcact gggtactata ttcactgggt caagcagacc      120

cctggtcaga gcctggagtg ggtgggcaga attttcccct acaatggagc tgcatcttat      180

aaccagaatt ttaagggcaa agcaactctg accgtggaca agagcaccac aactgcctac      240

atggagctga gctctctgcg cagcgaagac tctgctgtct atttctgcgc aaggtggctg      300

cgggtgtact ttgattattg gggtcagggc accacactga cagtcagttc ag              352


<210>  676
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  676
ggatactcct tcactgggta ctat                                              24


<210>  677
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  677
attttcccct acaatggagc tgca                                              24


<210>  678
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  678
gcaaggtggc tgcgggtgta ctttgattat                                        30


<210>  679
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  679
gaagtccagc tggtgcagtc cggagcagag gtggtcaaac ctggggaatc tgtgaaaatc       60

agttgtaagg cctca                                                        75


<210>  680
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  680
attcactggg tcaagcagac ccctggtcag agcctggagt gggtgggcag a                51


<210>  681
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  681
tcttataacc agaattttaa gggcaaagca actctgaccg tggacaagag caccacaact       60

gcctacatgg agctgagctc tctgcgcagc gaagactctg ctgtctattt ctgc            114


<210>  682
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  682
tggggtcagg gcaccacact gacagtcagt tcag                                   34


<210>  683
<211>  319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  683
gatattcaga tgacccagtc cccctcctcc ctgtcagctt ccgtcggcga tagagtcacc       60

attacctgtt ccgctagttc ctccgtcaca tacatgcact ggtatcagca gaagccaggg      120

aaagccccca agctgctgat ctacgagact agtaaactgg cttcaggagt gccaagcagg      180

ttctcaggca gcgggtccgg aactgactat acctttacaa tcagctccct gcagcctgaa      240

gatattgcca cctactattg cttccagggc agcgggtacc cattcacatt tggacagggc      300

actaaagtgg agatcaagc                                                   319


<210>  684
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  684
tcctccgtca catac                                                        15


<210>  685
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  685
gagactagt                                                                9


<210>  686
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  686
ttccagggca gcgggtaccc attcaca                                           27


<210>  687
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  687
gatattcaga tgacccagtc cccctcctcc ctgtcagctt ccgtcggcga tagagtcacc       60

attacctgtt ccgctagt                                                     78


<210>  688
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  688
atgcactggt atcagcagaa gccagggaaa gcccccaagc tgctgatcta c                51


<210>  689
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  689
aaactggctt caggagtgcc aagcaggttc tcaggcagcg ggtccggaac tgactatacc       60

tttacaatca gctccctgca gcctgaagat attgccacct actattgc                   108


<210>  690
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  690
tttggacagg gcactaaagt ggagatcaag c                                      31


<210>  691
<211>  352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  691
caggtgcagc tggtccagtc cggggccgag gtcaaaaagc ctggggagtc cgtcaaagtg       60

tcttgtaaag catctgggta tacatttacc gggtactata tccactgggt gagacaggca      120

cctggacagg gactggagtg gatggggagg attttcccat acaacggagc cgccagctat      180

aaccagaact tcaagggccg cgtgacaatc actgcagaca aaagtacctc aacagcctac      240

atggagctga gctccctgcg aagcgaagac acagccgtct actattgcgc tcggtggctg      300

agagtgtact tcgattattg gggccagggg accacagtca ccgtgtctag tg              352


<210>  692
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  692
gggtatacat ttaccgggta ctat                                              24


<210>  693
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  693
attttcccat acaacggagc cgcc                                              24


<210>  694
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  694
gctcggtggc tgagagtgta cttcgattat                                        30


<210>  695
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  695
caggtgcagc tggtccagtc cggggccgag gtcaaaaagc ctggggagtc cgtcaaagtg       60

tcttgtaaag catct                                                        75


<210>  696
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  696
atccactggg tgagacaggc acctggacag ggactggagt ggatggggag g                51


<210>  697
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  697
agctataacc agaacttcaa gggccgcgtg acaatcactg cagacaaaag tacctcaaca       60

gcctacatgg agctgagctc cctgcgaagc gaagacacag ccgtctacta ttgc            114


<210>  698
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  698
tggggccagg ggaccacagt caccgtgtct agtg                                   34


<210>  699
<211>  319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  699
gagatcgtcc tgactcagtc cccttccagc ctgtctacca gtgtcggtga cagagtgaca       60

atctcatgct ccgcttctag ttcagtgaca tacatgcact ggtatcagca gaagccaggc      120

aaagccccca agctgtggat ctacgagact tccaagctgg ctagcggtgt gccaggacgc      180

ttcagcggat ctggaagtgg gaactcttat accttcacca tctccagcct gcagccagaa      240

gatattgcta cctactattg cttccagggt tccggctacc ccttcacctt tggacagggg      300

acaaaagtgg agatcaaga                                                   319


<210>  700
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  700
agttcagtga catac                                                        15


<210>  701
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  701
gagacttcc                                                                9


<210>  702
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  702
ttccagggtt ccggctaccc cttcacc                                           27


<210>  703
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  703
gagatcgtcc tgactcagtc cccttccagc ctgtctacca gtgtcggtga cagagtgaca       60

atctcatgct ccgcttct                                                     78


<210>  704
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  704
atgcactggt atcagcagaa gccaggcaaa gcccccaagc tgtggatcta c                51


<210>  705
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  705
aagctggcta gcggtgtgcc aggacgcttc agcggatctg gaagtgggaa ctcttatacc       60

ttcaccatct ccagcctgca gccagaagat attgctacct actattgc                   108


<210>  706
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  706
tttggacagg ggacaaaagt ggagatcaag a                                      31


<210>  707
<211>  352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  707
gaagtccagc tggtgcagag cggagcagag gtgaagaaac ctggggaatc agtcaaagtg       60

tcctgtaagg catcaggata ctccttcacc gggtactata tccactgggt caagcaggca      120

cctggtcagg gactggagtg ggtgggtaga attttcccct acaatggcgc tgcaagctat      180

aaccagaatt ttaagggcaa agcaactctg accgtggaca agagctctag tacagcctac      240

atggagctgt catccctgcg ctctgaagac actgctgtct atttctgcgc aaggtggctg      300

cgggtgtact ttgattattg gggacagggg accacagtca cagtgagctc tg              352


<210>  708
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  708
ggatactcct tcaccgggta ctat                                              24


<210>  709
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  709
attttcccct acaatggcgc tgca                                              24


<210>  710
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  710
gcaaggtggc tgcgggtgta ctttgattat                                        30


<210>  711
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  711
gaagtccagc tggtgcagag cggagcagag gtgaagaaac ctggggaatc agtcaaagtg       60

tcctgtaagg catca                                                        75


<210>  712
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  712
atccactggg tcaagcaggc acctggtcag ggactggagt gggtgggtag a                51


<210>  713
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  713
agctataacc agaattttaa gggcaaagca actctgaccg tggacaagag ctctagtaca       60

gcctacatgg agctgtcatc cctgcgctct gaagacactg ctgtctattt ctgc            114


<210>  714
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  714
tggggacagg ggaccacagt cacagtgagc tctg                                   34


<210>  715
<211>  319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  715
gagatcgtgc tgactcagtc accctccagc atgtcaacct ccgtcggaga cagagtgaca       60

atgagctgct ctgcctctag ttcagtgacc tacatgcact ggtatcagca gaagccaggg      120

aaaagcccca agctgtggat ctacgagaca agcaagctgg cttctggtgt gcccagtcgc      180

ttcagtggct caggatccgg gaacgactat tccctgacca tttccagcat gcagccagaa      240

gatgtggcaa catactattg ctttcagggt agcggctacc ccttcacctt tggacagggg      300

acaaaactgg agatcaaga                                                   319


<210>  716
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  716
agttcagtga cctac                                                        15


<210>  717
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  717
gagacaagc                                                                9


<210>  718
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  718
tttcagggta gcggctaccc cttcacc                                           27


<210>  719
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  719
gagatcgtgc tgactcagtc accctccagc atgtcaacct ccgtcggaga cagagtgaca       60

atgagctgct ctgcctct                                                     78


<210>  720
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  720
atgcactggt atcagcagaa gccagggaaa agccccaagc tgtggatcta c                51


<210>  721
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  721
aagctggctt ctggtgtgcc cagtcgcttc agtggctcag gatccgggaa cgactattcc       60

ctgaccattt ccagcatgca gccagaagat gtggcaacat actattgc                   108


<210>  722
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  722
tttggacagg ggacaaaact ggagatcaag a                                      31


<210>  723
<211>  352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  723
gaagtccagc tggtgcagtc cggagcagag gtggtcaaac ctggggaaag cgtgaaaatc       60

tcttgtaagg ctagtggata ctcattcaca gggtactata ttcactgggt caagcagact      120

ccaggccagt ctctggagtg ggtgggcaga attttcccct acaatggagc tgcatcctat      180

aaccagaatt ttaagggcaa agcaaccctg acagtggaca agagcacttc taccgcctac      240

atggagctga gctctctgcg ctccgaagac agcgctgtct atttctgcgc aaggtggctg      300

cgggtgtact ttgattattg gggtcagggc accacactga cagtcagttc ag              352


<210>  724
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  724
ggatactcat tcacagggta ctat                                              24


<210>  725
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  725
attttcccct acaatggagc tgca                                              24


<210>  726
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  726
gcaaggtggc tgcgggtgta ctttgattat                                        30


<210>  727
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  727
gaagtccagc tggtgcagtc cggagcagag gtggtcaaac ctggggaaag cgtgaaaatc       60

tcttgtaagg ctagt                                                        75


<210>  728
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  728
attcactggg tcaagcagac tccaggccag tctctggagt gggtgggcag a                51


<210>  729
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  729
tcctataacc agaattttaa gggcaaagca accctgacag tggacaagag cacttctacc       60

gcctacatgg agctgagctc tctgcgctcc gaagacagcg ctgtctattt ctgc            114


<210>  730
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  730
tggggtcagg gcaccacact gacagtcagt tcag                                   34


<210>  731
<211>  319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  731
gaaattgtcc tgacccagtc ccctgctacc ctgtccctgt cccccggaga aagagcaacc       60

ctgtcctgtt cagcttcctc atctgtgtct tacatgcact ggtatcagca gaagccaggg      120

caggcaccca ggctgctgat ctacgagact agtaaactgg cattcggaat tcccgcacgc      180

ttttcaggca gcgggtccgg aaccgacttc accctgacaa tcagctccct ggagcctgaa      240

gatttcgccg tgtactattg ctttcagggc agcgggtatc cattcacatt tggacagggc      300

actcggctgg agatcaaga                                                   319


<210>  732
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  732
tcatctgtgt cttac                                                        15


<210>  733
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  733
gagactagt                                                                9


<210>  734
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  734
tttcagggca gcgggtatcc attcaca                                           27


<210>  735
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  735
gaaattgtcc tgacccagtc ccctgctacc ctgtccctgt cccccggaga aagagcaacc       60

ctgtcctgtt cagcttcc                                                     78


<210>  736
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  736
atgcactggt atcagcagaa gccagggcag gcacccaggc tgctgatcta c                51


<210>  737
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  737
aaactggcat tcggaattcc cgcacgcttt tcaggcagcg ggtccggaac cgacttcacc       60

ctgacaatca gctccctgga gcctgaagat ttcgccgtgt actattgc                   108


<210>  738
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  738
tttggacagg gcactcggct ggagatcaag a                                      31


<210>  739
<211>  352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  739
caggtccagc tggtccagtc tggggctgag gtcaaaaaac ccggctcttc cgtcaaagtc       60

tcctgcaaag catctggcta tacatttacc gggtactata tgcactgggt gagacaggca      120

cctgggcagg gactggagtg gatcgggagg attttcccat acaacggagc cgccagctat      180

aaccagaact tcaaggacaa agccactatc accgctgatg aaagtacaaa tactgcctac      240

atggagctga gctccctgag gtctgaagac actgcagtct actattgcgc ccggtggctg      300

agagtgtact tcgattattg gggccagggg acactggtca ccgtgagcag tg              352


<210>  740
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  740
ggctatacat ttaccgggta ctat                                              24


<210>  741
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  741
attttcccat acaacggagc cgcc                                              24


<210>  742
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  742
gcccggtggc tgagagtgta cttcgattat                                        30


<210>  743
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  743
caggtccagc tggtccagtc tggggctgag gtcaaaaaac ccggctcttc cgtcaaagtc       60

tcctgcaaag catct                                                        75


<210>  744
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  744
atgcactggg tgagacaggc acctgggcag ggactggagt ggatcgggag g                51


<210>  745
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  745
agctataacc agaacttcaa ggacaaagcc actatcaccg ctgatgaaag tacaaatact       60

gcctacatgg agctgagctc cctgaggtct gaagacactg cagtctacta ttgc            114


<210>  746
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  746
tggggccagg ggacactggt caccgtgagc agtg                                   34


<210>  747
<211>  319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  747
gagaaggtcc tgacacagtc acccgctacc ctgtccctga gccctggcga gagagccact       60

atgacctgct cagcttccag ctctgtgtcc tacatgcact ggtatcagca gaagccagga      120

acctctccca aactgtggat ctacgaaacc agtaagctgg ctttcggggt gccagcacgc      180

ttttctggca gtggatcagg gaactcctat agcctgacca ttagttcact ggaaccagaa      240

gacttcgctg tgtactattg ctttcagggt agcggctacc ccttcacctt tggacagggg      300

acaagactgg agatcaagc                                                   319


<210>  748
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  748
agctctgtgt cctac                                                        15


<210>  749
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  749
gaaaccagt                                                                9


<210>  750
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  750
tttcagggta gcggctaccc cttcacc                                           27


<210>  751
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  751
gagaaggtcc tgacacagtc acccgctacc ctgtccctga gccctggcga gagagccact       60

atgacctgct cagcttcc                                                     78


<210>  752
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  752
atgcactggt atcagcagaa gccaggaacc tctcccaaac tgtggatcta c                51


<210>  753
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  753
aagctggctt tcggggtgcc agcacgcttt tctggcagtg gatcagggaa ctcctatagc       60

ctgaccatta gttcactgga accagaagac ttcgctgtgt actattgc                   108


<210>  754
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  754
tttggacagg ggacaagact ggagatcaag c                                      31


<210>  755
<211>  352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  755
gaagtgcagc tgctgcagtc cggagctgag gtcaagaaac ccgggtcatc cgtgaagatt       60

agctgtaaag catctgatta cagttttacc ggctactata tgcactgggt gaagcaggca      120

cctggtcagg gactggagtg gatcggtaga attttcccct acaatggcgc tgcatcctat      180

aaccagaatt ttaaggacaa agctaccctg acagtggata agagctctag taccgcatat      240

atggagctgc attcactgcg ctccgaagac acagccgtct actattgcac taggtggctg      300

cgggtgtact tcgattattg gggacagggg accctggtca cagtgtcatc cg              352


<210>  756
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  756
gattacagtt ttaccggcta ctat                                              24


<210>  757
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  757
attttcccct acaatggcgc tgca                                              24


<210>  758
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  758
actaggtggc tgcgggtgta cttcgattat                                        30


<210>  759
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  759
gaagtgcagc tgctgcagtc cggagctgag gtcaagaaac ccgggtcatc cgtgaagatt       60

agctgtaaag catct                                                        75


<210>  760
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  760
atgcactggg tgaagcaggc acctggtcag ggactggagt ggatcggtag a                51


<210>  761
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  761
tcctataacc agaattttaa ggacaaagct accctgacag tggataagag ctctagtacc       60

gcatatatgg agctgcattc actgcgctcc gaagacacag ccgtctacta ttgc            114


<210>  762
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  762
tggggacagg ggaccctggt cacagtgtca tccg                                   34


<210>  763
<211>  319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  763
gaaaaggtcc tgactcagtc ccccgctact ctgtcagcat cccctggcga gagagtcacc       60

atgagctgct ctgcctccag ctctgtgtct tacatgcact ggtatcagca gaagcctggt      120

cagagtccca aactgtggat ctacgaaact tcaaagctgg cattcggcgt gccagcccgc      180

tttagtggct caggatccgg gaccgactat tccctgacaa ttagttcaat ggagccagaa      240

gatttcgcta catactattg ctttcagggt agcggctacc ccttcacttt tggacagggg      300

accagactgg agatcaagc                                                   319


<210>  764
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  764
agctctgtgt cttac                                                        15


<210>  765
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  765
gaaacttca                                                                9


<210>  766
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  766
tttcagggta gcggctaccc cttcact                                           27


<210>  767
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  767
gaaaaggtcc tgactcagtc ccccgctact ctgtcagcat cccctggcga gagagtcacc       60

atgagctgct ctgcctcc                                                     78


<210>  768
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  768
atgcactggt atcagcagaa gcctggtcag agtcccaaac tgtggatcta c                51


<210>  769
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  769
aagctggcat tcggcgtgcc agcccgcttt agtggctcag gatccgggac cgactattcc       60

ctgacaatta gttcaatgga gccagaagat ttcgctacat actattgc                   108


<210>  770
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  770
tttggacagg ggaccagact ggagatcaag c                                      31


<210>  771
<211>  352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  771
gaagtgcagc tgctgcagtc cggtgcagag gtggtcaagc caggatcatc cgtgaagatt       60

agctgtaaag ctagcggtta ctcttttacc ggctactata tgcactgggt gaagcaggca      120

cctggtcagg gcctggagtg gatcggaaga attttcccct acaacggggc tgcatcttat      180

aaccagaatt ttaaggacaa agccacactg actgctgata agtccaccaa tacagcatat      240

atggagctga gctctctgcg cagtgaagac tcagccgtct actattgcac caggtggctg      300

cgggtgtact tcgattattg gggacagggg accctggtca cagtgagttc ag              352


<210>  772
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  772
ggttactctt ttaccggcta ctat                                              24


<210>  773
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  773
attttcccct acaacggggc tgca                                              24


<210>  774
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  774
accaggtggc tgcgggtgta cttcgattat                                        30


<210>  775
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  775
gaagtgcagc tgctgcagtc cggtgcagag gtggtcaagc caggatcatc cgtgaagatt       60

agctgtaaag ctagc                                                        75


<210>  776
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  776
atgcactggg tgaagcaggc acctggtcag ggcctggagt ggatcggaag a                51


<210>  777
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  777
tcttataacc agaattttaa ggacaaagcc acactgactg ctgataagtc caccaataca       60

gcatatatgg agctgagctc tctgcgcagt gaagactcag ccgtctacta ttgc            114


<210>  778
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  778
tggggacagg ggaccctggt cacagtgagt tcag                                   34


<210>  779
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  779
gagaatgtcc tgactcagtc ccctgctatt atggccgctt ccctggggca gaaagtgact       60

atgacctgtt ccgcttcctc ttccgtcagc tcctcttacc tgcactggta tcagcagaag      120

tctggcgcta gtccaaaacc cctgatccat cgaaccagca cactggcttc cggagtgcca      180

gcaagattct ctggcagtgg gtcaggaaca agctactccc tgactattag ttcagtcgag      240

gcagaagacg atgccaccta ctattgccag cagtggtctg ggtaccctta tacctttggc      300

gggggaacaa agctggagat caaa                                             324


<210>  780
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  780

Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ala Ala Ser Leu Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Pro Leu 
        35                  40                  45              


Ile His Arg Thr Ser Thr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu 
65                  70                  75                  80  


Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  781
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  781
gacgtgcagc tgcaggaatc tgggcctggg ctggtgaaac ctagtcagtc tctgtctctg       60

acctgtaccg tgaccggata ctcaatcacc tccgattctg cctggaactg gatcaggcag      120

ttccctggca acaatctgga gtggatggga tacattagtt attcaggcag cacatcctac      180

aatccatccc tgaagtctag gatcagtatt acccgcgaca caagtaaaaa ccagttcttt      240

ctgcagctga attcagtgac cacagaagat accgctacat actattgcgc acggagatca      300

cgggtgagct tctactttga ctattggggg cagggaacta ccctgactgt cagctcc         357


<210>  782
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  782

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Ser Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Asn Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Arg Val Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  783
<211>  2366
<212>  PRT
<213>  Clostridium difficile

<400>  783

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
1               5                   10                  15      


Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          


Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              


Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
65                  70                  75                  80  


Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys 
                85                  90                  95      


Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
            100                 105                 110         


Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
        115                 120                 125             


Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 


Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn 
145                 150                 155                 160 


Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met 
                165                 170                 175     


Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala 
            180                 185                 190         


Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr 
        195                 200                 205             


Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr 
    210                 215                 220                 


Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val 
225                 230                 235                 240 


Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu 
                245                 250                 255     


Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu 
            260                 265                 270         


Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp 
        275                 280                 285             


Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro 
    290                 295                 300                 


Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile 
305                 310                 315                 320 


Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp 
                325                 330                 335     


Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser 
            340                 345                 350         


Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala 
        355                 360                 365             


Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn 
    370                 375                 380                 


Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val 
385                 390                 395                 400 


Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro 
                405                 410                 415     


Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile 
            420                 425                 430         


Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met 
        435                 440                 445             


Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr 
    450                 455                 460                 


Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp 
465                 470                 475                 480 


Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala 
                485                 490                 495     


Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr 
            500                 505                 510         


Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys 
        515                 520                 525             


Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly 
    530                 535                 540                 


Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu 
545                 550                 555                 560 


Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly 
                565                 570                 575     


Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu 
            580                 585                 590         


Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe 
        595                 600                 605             


Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly 
    610                 615                 620                 


Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile 
625                 630                 635                 640 


Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp 
                645                 650                 655     


Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser 
            660                 665                 670         


Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro 
        675                 680                 685             


Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser 
    690                 695                 700                 


Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys 
705                 710                 715                 720 


Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile 
                725                 730                 735     


Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg 
            740                 745                 750         


Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile 
        755                 760                 765             


Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu 
    770                 775                 780                 


Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu 
785                 790                 795                 800 


Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu 
                805                 810                 815     


Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile 
            820                 825                 830         


Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr 
        835                 840                 845             


Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser 
    850                 855                 860                 


Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp 
865                 870                 875                 880 


Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe 
                885                 890                 895     


Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu 
            900                 905                 910         


Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu 
        915                 920                 925             


Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu 
    930                 935                 940                 


Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn 
945                 950                 955                 960 


Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu 
                965                 970                 975     


Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln 
            980                 985                 990         


Leu Phe Ser Thr Gly Leu Asn Thr  Ile Thr Asp Ala Ala  Lys Val Val 
        995                 1000                 1005             


Glu Leu  Val Ser Thr Ala Leu  Asp Glu Thr Ile Asp  Leu Leu Pro 
    1010                 1015                 1020             


Thr Leu  Ser Glu Gly Leu Pro  Ile Ile Ala Thr Ile  Ile Asp Gly 
    1025                 1030                 1035             


Val Ser  Leu Gly Ala Ala Ile  Lys Glu Leu Ser Glu  Thr Ser Asp 
    1040                 1045                 1050             


Pro Leu  Leu Arg Gln Glu Ile  Glu Ala Lys Ile Gly  Ile Met Ala 
    1055                 1060                 1065             


Val Asn  Leu Thr Thr Ala Thr  Thr Ala Ile Ile Thr  Ser Ser Leu 
    1070                 1075                 1080             


Gly Ile  Ala Ser Gly Phe Ser  Ile Leu Leu Val Pro  Leu Ala Gly 
    1085                 1090                 1095             


Ile Ser  Ala Gly Ile Pro Ser  Leu Val Asn Asn Glu  Leu Val Leu 
    1100                 1105                 1110             


Arg Asp  Lys Ala Thr Lys Val  Val Asp Tyr Phe Lys  His Val Ser 
    1115                 1120                 1125             


Leu Val  Glu Thr Glu Gly Val  Phe Thr Leu Leu Asp  Asp Lys Ile 
    1130                 1135                 1140             


Met Met  Pro Gln Asp Asp Leu  Val Ile Ser Glu Ile  Asp Phe Asn 
    1145                 1150                 1155             


Asn Asn  Ser Ile Val Leu Gly  Lys Cys Glu Ile Trp  Arg Met Glu 
    1160                 1165                 1170             


Gly Gly  Ser Gly His Thr Val  Thr Asp Asp Ile Asp  His Phe Phe 
    1175                 1180                 1185             


Ser Ala  Pro Ser Ile Thr Tyr  Arg Glu Pro His Leu  Ser Ile Tyr 
    1190                 1195                 1200             


Asp Val  Leu Glu Val Gln Lys  Glu Glu Leu Asp Leu  Ser Lys Asp 
    1205                 1210                 1215             


Leu Met  Val Leu Pro Asn Ala  Pro Asn Arg Val Phe  Ala Trp Glu 
    1220                 1225                 1230             


Thr Gly  Trp Thr Pro Gly Leu  Arg Ser Leu Glu Asn  Asp Gly Thr 
    1235                 1240                 1245             


Lys Leu  Leu Asp Arg Ile Arg  Asp Asn Tyr Glu Gly  Glu Phe Tyr 
    1250                 1255                 1260             


Trp Arg  Tyr Phe Ala Phe Ile  Ala Asp Ala Leu Ile  Thr Thr Leu 
    1265                 1270                 1275             


Lys Pro  Arg Tyr Glu Asp Thr  Asn Ile Arg Ile Asn  Leu Asp Ser 
    1280                 1285                 1290             


Asn Thr  Arg Ser Phe Ile Val  Pro Ile Ile Thr Thr  Glu Tyr Ile 
    1295                 1300                 1305             


Arg Glu  Lys Leu Ser Tyr Ser  Phe Tyr Gly Ser Gly  Gly Thr Tyr 
    1310                 1315                 1320             


Ala Leu  Ser Leu Ser Gln Tyr  Asn Met Gly Ile Asn  Ile Glu Leu 
    1325                 1330                 1335             


Ser Glu  Ser Asp Val Trp Ile  Ile Asp Val Asp Asn  Val Val Arg 
    1340                 1345                 1350             


Asp Val  Thr Ile Glu Ser Asp  Lys Ile Lys Lys Gly  Asp Leu Ile 
    1355                 1360                 1365             


Glu Gly  Ile Leu Ser Thr Leu  Ser Ile Glu Glu Asn  Lys Ile Ile 
    1370                 1375                 1380             


Leu Asn  Ser His Glu Ile Asn  Phe Ser Gly Glu Val  Asn Gly Ser 
    1385                 1390                 1395             


Asn Gly  Phe Val Ser Leu Thr  Phe Ser Ile Leu Glu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Ile  Ile Glu Val Asp Leu  Leu Ser Lys Ser Tyr  Lys Leu Leu 
    1415                 1420                 1425             


Ile Ser  Gly Glu Leu Lys Ile  Leu Met Leu Asn Ser  Asn His Ile 
    1430                 1435                 1440             


Gln Gln  Lys Ile Asp Tyr Ile  Gly Phe Asn Ser Glu  Leu Gln Lys 
    1445                 1450                 1455             


Asn Ile  Pro Tyr Ser Phe Val  Asp Ser Glu Gly Lys  Glu Asn Gly 
    1460                 1465                 1470             


Phe Ile  Asn Gly Ser Thr Lys  Glu Gly Leu Phe Val  Ser Glu Leu 
    1475                 1480                 1485             


Pro Asp  Val Val Leu Ile Ser  Lys Val Tyr Met Asp  Asp Ser Lys 
    1490                 1495                 1500             


Pro Ser  Phe Gly Tyr Tyr Ser  Asn Asn Leu Lys Asp  Val Lys Val 
    1505                 1510                 1515             


Ile Thr  Lys Asp Asn Val Asn  Ile Leu Thr Gly Tyr  Tyr Leu Lys 
    1520                 1525                 1530             


Asp Asp  Ile Lys Ile Ser Leu  Ser Leu Thr Leu Gln  Asp Glu Lys 
    1535                 1540                 1545             


Thr Ile  Lys Leu Asn Ser Val  His Leu Asp Glu Ser  Gly Val Ala 
    1550                 1555                 1560             


Glu Ile  Leu Lys Phe Met Asn  Arg Lys Gly Asn Thr  Asn Thr Ser 
    1565                 1570                 1575             


Asp Ser  Leu Met Ser Phe Leu  Glu Ser Met Asn Ile  Lys Ser Ile 
    1580                 1585                 1590             


Phe Val  Asn Phe Leu Gln Ser  Asn Ile Lys Phe Ile  Leu Asp Ala 
    1595                 1600                 1605             


Asn Phe  Ile Ile Ser Gly Thr  Thr Ser Ile Gly Gln  Phe Glu Phe 
    1610                 1615                 1620             


Ile Cys  Asp Glu Asn Asp Asn  Ile Gln Pro Tyr Phe  Ile Lys Phe 
    1625                 1630                 1635             


Asn Thr  Leu Glu Thr Asn Tyr  Thr Leu Tyr Val Gly  Asn Arg Gln 
    1640                 1645                 1650             


Asn Met  Ile Val Glu Pro Asn  Tyr Asp Leu Asp Asp  Ser Gly Asp 
    1655                 1660                 1665             


Ile Ser  Ser Thr Val Ile Asn  Phe Ser Gln Lys Tyr  Leu Tyr Gly 
    1670                 1675                 1680             


Ile Asp  Ser Cys Val Asn Lys  Val Val Ile Ser Pro  Asn Ile Tyr 
    1685                 1690                 1695             


Thr Asp  Glu Ile Asn Ile Thr  Pro Val Tyr Glu Thr  Asn Asn Thr 
    1700                 1705                 1710             


Tyr Pro  Glu Val Ile Val Leu  Asp Ala Asn Tyr Ile  Asn Glu Lys 
    1715                 1720                 1725             


Ile Asn  Val Asn Ile Asn Asp  Leu Ser Ile Arg Tyr  Val Trp Ser 
    1730                 1735                 1740             


Asn Asp  Gly Asn Asp Phe Ile  Leu Met Ser Thr Ser  Glu Glu Asn 
    1745                 1750                 1755             


Lys Val  Ser Gln Val Lys Ile  Arg Phe Val Asn Val  Phe Lys Asp 
    1760                 1765                 1770             


Lys Thr  Leu Ala Asn Lys Leu  Ser Phe Asn Phe Ser  Asp Lys Gln 
    1775                 1780                 1785             


Asp Val  Pro Val Ser Glu Ile  Ile Leu Ser Phe Thr  Pro Ser Tyr 
    1790                 1795                 1800             


Tyr Glu  Asp Gly Leu Ile Gly  Tyr Asp Leu Gly Leu  Val Ser Leu 
    1805                 1810                 1815             


Tyr Asn  Glu Lys Phe Tyr Ile  Asn Asn Phe Gly Met  Met Val Ser 
    1820                 1825                 1830             


Gly Leu  Ile Tyr Ile Asn Asp  Ser Leu Tyr Tyr Phe  Lys Pro Pro 
    1835                 1840                 1845             


Val Asn  Asn Leu Ile Thr Gly  Phe Val Thr Val Gly  Asp Asp Lys 
    1850                 1855                 1860             


Tyr Tyr  Phe Asn Pro Ile Asn  Gly Gly Ala Ala Ser  Ile Gly Glu 
    1865                 1870                 1875             


Thr Ile  Ile Asp Asp Lys Asn  Tyr Tyr Phe Asn Gln  Ser Gly Val 
    1880                 1885                 1890             


Leu Gln  Thr Gly Val Phe Ser  Thr Glu Asp Gly Phe  Lys Tyr Phe 
    1895                 1900                 1905             


Ala Pro  Ala Asn Thr Leu Asp  Glu Asn Leu Glu Gly  Glu Ala Ile 
    1910                 1915                 1920             


Asp Phe  Thr Gly Lys Leu Ile  Ile Asp Glu Asn Ile  Tyr Tyr Phe 
    1925                 1930                 1935             


Asp Asp  Asn Tyr Arg Gly Ala  Val Glu Trp Lys Glu  Leu Asp Gly 
    1940                 1945                 1950             


Glu Met  His Tyr Phe Ser Pro  Glu Thr Gly Lys Ala  Phe Lys Gly 
    1955                 1960                 1965             


Leu Asn  Gln Ile Gly Asp Tyr  Lys Tyr Tyr Phe Asn  Ser Asp Gly 
    1970                 1975                 1980             


Val Met  Gln Lys Gly Phe Val  Ser Ile Asn Asp Asn  Lys His Tyr 
    1985                 1990                 1995             


Phe Asp  Asp Ser Gly Val Met  Lys Val Gly Tyr Thr  Glu Ile Asp 
    2000                 2005                 2010             


Gly Lys  His Phe Tyr Phe Ala  Glu Asn Gly Glu Met  Gln Ile Gly 
    2015                 2020                 2025             


Val Phe  Asn Thr Glu Asp Gly  Phe Lys Tyr Phe Ala  His His Asn 
    2030                 2035                 2040             


Glu Asp  Leu Gly Asn Glu Glu  Gly Glu Glu Ile Ser  Tyr Ser Gly 
    2045                 2050                 2055             


Ile Leu  Asn Phe Asn Asn Lys  Ile Tyr Tyr Phe Asp  Asp Ser Phe 
    2060                 2065                 2070             


Thr Ala  Val Val Gly Trp Lys  Asp Leu Glu Asp Gly  Ser Lys Tyr 
    2075                 2080                 2085             


Tyr Phe  Asp Glu Asp Thr Ala  Glu Ala Tyr Ile Gly  Leu Ser Leu 
    2090                 2095                 2100             


Ile Asn  Asp Gly Gln Tyr Tyr  Phe Asn Asp Asp Gly  Ile Met Gln 
    2105                 2110                 2115             


Val Gly  Phe Val Thr Ile Asn  Asp Lys Val Phe Tyr  Phe Ser Asp 
    2120                 2125                 2130             


Ser Gly  Ile Ile Glu Ser Gly  Val Gln Asn Ile Asp  Asp Asn Tyr 
    2135                 2140                 2145             


Phe Tyr  Ile Asp Asp Asn Gly  Ile Val Gln Ile Gly  Val Phe Asp 
    2150                 2155                 2160             


Thr Ser  Asp Gly Tyr Lys Tyr  Phe Ala Pro Ala Asn  Thr Val Asn 
    2165                 2170                 2175             


Asp Asn  Ile Tyr Gly Gln Ala  Val Glu Tyr Ser Gly  Leu Val Arg 
    2180                 2185                 2190             


Val Gly  Glu Asp Val Tyr Tyr  Phe Gly Glu Thr Tyr  Thr Ile Glu 
    2195                 2200                 2205             


Thr Gly  Trp Ile Tyr Asp Met  Glu Asn Glu Ser Asp  Lys Tyr Tyr 
    2210                 2215                 2220             


Phe Asn  Pro Glu Thr Lys Lys  Ala Cys Lys Gly Ile  Asn Leu Ile 
    2225                 2230                 2235             


Asp Asp  Ile Lys Tyr Tyr Phe  Asp Glu Lys Gly Ile  Met Arg Thr 
    2240                 2245                 2250             


Gly Leu  Ile Ser Phe Glu Asn  Asn Asn Tyr Tyr Phe  Asn Glu Asn 
    2255                 2260                 2265             


Gly Glu  Met Gln Phe Gly Tyr  Ile Asn Ile Glu Asp  Lys Met Phe 
    2270                 2275                 2280             


Tyr Phe  Gly Glu Asp Gly Val  Met Gln Ile Gly Val  Phe Asn Thr 
    2285                 2290                 2295             


Pro Asp  Gly Phe Lys Tyr Phe  Ala His Gln Asn Thr  Leu Asp Glu 
    2300                 2305                 2310             


Asn Phe  Glu Gly Glu Ser Ile  Asn Tyr Thr Gly Trp  Leu Asp Leu 
    2315                 2320                 2325             


Asp Glu  Lys Arg Tyr Tyr Phe  Thr Asp Glu Tyr Ile  Ala Ala Thr 
    2330                 2335                 2340             


Gly Ser  Val Ile Ile Asp Gly  Glu Glu Tyr Tyr Phe  Asp Pro Asp 
    2345                 2350                 2355             


Thr Ala  Gln Leu Val Ile Ser  Glu 
    2360                 2365     


<210>  784
<211>  7101
<212>  DNA
<213>  Clostridium difficile

<400>  784
atgagtttag ttaatagaaa acagttagaa aaaatggcaa atgtaagatt tcgtactcaa       60

gaagatgaat atgttgcaat attggatgct ttagaagaat atcataatat gtcagagaat      120

actgtagtcg aaaaatattt aaaattaaaa gatataaata gtttaacaga tatttatata      180

gatacatata aaaaatctgg tagaaataaa gccttaaaaa aatttaagga atatctagtt      240

acagaagtat tagagctaaa gaataataat ttaactccag ttgagaaaaa tttacatttt      300

gtttggattg gaggtcaaat aaatgacact gctattaatt atataaatca atggaaagat      360

gtaaatagtg attataatgt taatgttttt tatgatagta atgcattttt gataaacaca      420

ttgaaaaaaa ctgtagtaga atcagcaata aatgatacac ttgaatcatt tagagaaaac      480

ttaaatgacc ctagatttga ctataataaa ttcttcagaa aacgtatgga aataatttat      540

gataaacaga aaaatttcat aaactactat aaagctcaaa gagaagaaaa tcctgaactt      600

ataattgatg atattgtaaa gacatatctt tcaaatgagt attcaaagga gatagatgaa      660

cttaatacct atattgaaga atccttaaat aaaattacac agaatagtgg aaatgatgtt      720

agaaactttg aagaatttaa aaatggagag tcattcaact tatatgaaca agagttggta      780

gaaaggtgga atttagctgc tgcttctgac atattaagaa tatctgcatt aaaagaaatt      840

ggtggtatgt atttagatgt tgatatgtta ccaggaatac aaccagactt atttgagtct      900

atagagaaac ctagttcagt aacagtggat ttttgggaaa tgacaaagtt agaagctata      960

atgaaataca aagaatatat accagaatat acctcagaac attttgacat gttagacgaa     1020

gaagttcaaa gtagttttga atctgttcta gcttctaagt cagataaatc agaaatattc     1080

tcatcacttg gtgatatgga ggcatcacca ctagaagtta aaattgcatt taatagtaag     1140

ggtattataa atcaagggct aatttctgtg aaagactcat attgtagcaa tttaatagta     1200

aaacaaatcg agaatagata taaaatattg aataatagtt taaatccagc tattagcgag     1260

gataatgatt ttaatactac aacgaatacc tttattgata gtataatggc tgaagctaat     1320

gcagataatg gtagatttat gatggaacta ggaaagtatt taagagttgg tttcttccca     1380

gatgttaaaa ctactattaa cttaagtggc cctgaagcat atgcggcagc ttatcaagat     1440

ttattaatgt ttaaagaagg cagtatgaat atccatttga tagaagctga tttaagaaac     1500

tttgaaatct ctaaaactaa tatttctcaa tcaactgaac aagaaatggc tagcttatgg     1560

tcatttgacg atgcaagagc taaagctcaa tttgaagaat ataaaaggaa ttattttgaa     1620

ggttctcttg gtgaagatga taatcttgat ttttctcaaa atatagtagt tgacaaggag     1680

tatcttttag aaaaaatatc ttcattagca agaagttcag agagaggata tatacactat     1740

attgttcagt tacaaggaga taaaattagt tatgaagcag catgtaactt atttgcaaag     1800

actccttatg atagtgtact gtttcagaaa aatatagaag attcagaaat tgcatattat     1860

tataatcctg gagatggtga aatacaagaa atagacaagt ataaaattcc aagtataatt     1920

tctgatagac ctaagattaa attaacattt attggtcatg gtaaagatga atttaatact     1980

gatatatttg caggttttga tgtagattca ttatccacag aaatagaagc agcaatagat     2040

ttagctaaag aggatatttc tcctaagtca atagaaataa atttattagg atgtaatatg     2100

tttagctact ctatcaacgt agaggagact tatcctggaa aattattact taaagttaaa     2160

gataaaatat cagaattaat gccatctata agtcaagact ctattatagt aagtgcaaat     2220

caatatgaag ttagaataaa tagtgaagga agaagagaat tattggatca ttctggtgaa     2280

tggataaata aagaagaaag tattataaag gatatttcat caaaagaata tatatcattt     2340

aatcctaaag aaaataaaat tacagtaaaa tctaaaaatt tacctgagct atctacatta     2400

ttacaagaaa ttagaaataa ttctaattca agtgatattg aactagaaga aaaagtaatg     2460

ttaacagaat gtgagataaa tgttatttca aatatagata cgcaaattgt tgaggaaagg     2520

attgaagaag ctaagaattt aacttctgac tctattaatt atataaaaga tgaatttaaa     2580

ctaatagaat ctatttctga tgcactatgt gacttaaaac aacagaatga attagaagat     2640

tctcatttta tatcttttga ggacatatca gagactgatg agggatttag tataagattt     2700

attaataaag aaactggaga atctatattt gtagaaactg aaaaaacaat attctctgaa     2760

tatgctaatc atataactga agagatttct aagataaaag gtactatatt tgatactgta     2820

aatggtaagt tagtaaaaaa agtaaattta gatactacac acgaagtaaa tactttaaat     2880

gctgcatttt ttatacaatc attaatagaa tataatagtt ctaaagaatc tcttagtaat     2940

ttaagtgtag caatgaaagt ccaagtttac gctcaattat ttagtactgg tttaaatact     3000

attacagatg cagccaaagt tgttgaatta gtatcaactg cattagatga aactatagac     3060

ttacttccta cattatctga aggattacct ataattgcaa ctattataga tggtgtaagt     3120

ttaggtgcag caatcaaaga gctaagtgaa acgagtgacc cattattaag acaagaaata     3180

gaagctaaga taggtataat ggcagtaaat ttaacaacag ctacaactgc aatcattact     3240

tcatctttgg ggatagctag tggatttagt atacttttag ttcctttagc aggaatttca     3300

gcaggtatac caagcttagt aaacaatgaa cttgtacttc gagataaggc aacaaaggtt     3360

gtagattatt ttaaacatgt ttcattagtt gaaactgaag gagtatttac tttattagat     3420

gataaaataa tgatgccaca agatgattta gtgatatcag aaatagattt taataataat     3480

tcaatagttt taggtaaatg tgaaatctgg agaatggaag gtggttcagg tcatactgta     3540

actgatgata tagatcactt cttttcagca ccatcaataa catatagaga gccacactta     3600

tctatatatg acgtattgga agtacaaaaa gaagaacttg atttgtcaaa agatttaatg     3660

gtattaccta atgctccaaa tagagtattt gcttgggaaa caggatggac accaggttta     3720

agaagcttag aaaatgatgg cacaaaactg ttagaccgta taagagataa ctatgaaggt     3780

gagttttatt ggagatattt tgcttttata gctgatgctt taataacaac attaaaacca     3840

agatatgaag atactaatat aagaataaat ttagatagta atactagaag ttttatagtt     3900

ccaataataa ctacagaata tataagagaa aaattatcat attctttcta tggttcagga     3960

ggaacttatg cattgtctct ttctcaatat aatatgggta taaatataga attaagtgaa     4020

agtgatgttt ggattataga tgttgataat gttgtgagag atgtaactat agaatctgat     4080

aaaattaaaa aaggtgattt aatagaaggt attttatcta cactaagtat tgaagagaat     4140

aaaattatct taaatagcca tgagattaat ttttctggtg aggtaaatgg aagtaatgga     4200

tttgtttctt taacattttc aattttagaa ggaataaatg caattataga agttgattta     4260

ttatctaaat catataaatt acttatttct ggcgaattaa aaatattgat gttaaattca     4320

aatcatattc aacagaaaat agattatata ggattcaata gcgaattaca gaaaaatata     4380

ccatatagct ttgtagatag tgaaggaaaa gagaatggtt ttattaatgg ttcaacaaaa     4440

gaaggtttat ttgtatctga attacctgat gtagttctta taagtaaggt ttatatggat     4500

gatagtaagc cttcatttgg atattatagt aataatttga aagatgtcaa agttataact     4560

aaagataatg ttaatatatt aacaggttat tatcttaagg atgatataaa aatctctctt     4620

tctttgactc tacaagatga aaaaactata aagttaaata gtgtgcattt agatgaaagt     4680

ggagtagctg agattttgaa gttcatgaat agaaaaggta atacaaatac ttcagattct     4740

ttaatgagct ttttagaaag tatgaatata aaaagtattt tcgttaattt cttacaatct     4800

aatattaagt ttatattaga tgctaatttt ataataagtg gtactacttc tattggccaa     4860

tttgagttta tttgtgatga aaatgataat atacaaccat atttcattaa gtttaataca     4920

ctagaaacta attatacttt atatgtagga aatagacaaa atatgatagt ggaaccaaat     4980

tatgatttag atgattctgg agatatatct tcaactgtta tcaatttctc tcaaaagtat     5040

ctttatggaa tagacagttg tgttaataaa gttgtaattt caccaaatat ttatacagat     5100

gaaataaata taacgcctgt atatgaaaca aataatactt atccagaagt tattgtatta     5160

gatgcaaatt atataaatga aaaaataaat gttaatatca atgatctatc tatacgatat     5220

gtatggagta atgatggtaa tgattttatt cttatgtcaa ctagtgaaga aaataaggtg     5280

tcacaagtta aaataagatt cgttaatgtt tttaaagata agactttggc aaataagcta     5340

tcttttaact ttagtgataa acaagatgta cctgtaagtg aaataatctt atcatttaca     5400

ccttcatatt atgaggatgg attgattggc tatgatttgg gtctagtttc tttatataat     5460

gagaaatttt atattaataa ctttggaatg atggtatctg gattaatata tattaatgat     5520

tcattatatt attttaaacc accagtaaat aatttgataa ctggatttgt gactgtaggc     5580

gatgataaat actactttaa tccaattaat ggtggagctg cttcaattgg agagacaata     5640

attgatgaca aaaattatta tttcaaccaa agtggagtgt tacaaacagg tgtatttagt     5700

acagaagatg gatttaaata ttttgcccca gctaatacac ttgatgaaaa cctagaagga     5760

gaagcaattg attttactgg aaaattaatt attgacgaaa atatttatta ttttgatgat     5820

aattatagag gagctgtaga atggaaagaa ttagatggtg aaatgcacta ttttagccca     5880

gaaacaggta aagcttttaa aggtctaaat caaataggtg attataaata ctatttcaat     5940

tctgatggag ttatgcaaaa aggatttgtt agtataaatg ataataaaca ctattttgat     6000

gattctggtg ttatgaaagt aggttacact gaaatagatg gcaagcattt ctactttgct     6060

gaaaacggag aaatgcaaat aggagtattt aatacagaag atggatttaa atattttgct     6120

catcataatg aagatttagg aaatgaagaa ggtgaagaaa tctcatattc tggtatatta     6180

aatttcaata ataaaattta ctattttgat gattcattta cagctgtagt tggatggaaa     6240

gatttagagg atggttcaaa gtattatttt gatgaagata cagcagaagc atatataggt     6300

ttgtcattaa taaatgatgg tcaatattat tttaatgatg atggaattat gcaagttgga     6360

tttgtcacta taaatgataa agtcttctac ttctctgact ctggaattat agaatctgga     6420

gtacaaaaca tagatgacaa ttatttctat atagatgata atggtatagt tcaaattggt     6480

gtatttgata cttcagatgg atataaatat tttgcacctg ctaatactgt aaatgataat     6540

atttacggac aagcagttga atatagtggt ttagttagag ttggtgaaga tgtatattat     6600

tttggagaaa catatacaat tgagactgga tggatatatg atatggaaaa tgaaagtgat     6660

aaatattatt tcaatccaga aactaaaaaa gcatgcaaag gtattaattt aattgatgat     6720

ataaaatatt attttgatga gaagggcata atgagaacgg gtcttatatc atttgaaaat     6780

aataattatt actttaatga gaatggtgaa atgcaatttg gttatataaa tatagaagat     6840

aagatgttct attttggtga agatggtgtc atgcagattg gagtatttaa tacaccagat     6900

ggatttaaat actttgcaca tcaaaatact ttggatgaga attttgaggg agaatcaata     6960

aactatactg gttggttaga tttagatgaa aagagatatt attttacaga tgaatatatt     7020

gcagcaactg gttcagttat tattgatggt gaggagtatt attttgatcc tgatacagct     7080

caattagtga ttagtgaata g                                               7101


