                         SEQUENCE LISTING

<110>  Genentech Inc.et al
        
<120>  RON Compositions and Methods of Use thereof

<130>  P5505R1-WO

<150> 61/823,744
<151> 2013-05-15

<150> 61/732,048
<151> 2012-11-30

<160>  88    

<170>  PatentIn version 3.5

<210>  1
<211>  2160
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(2160)

<400>  1
atg ggg tgg ctc cca ctc ctg ctg ctt ctg act caa tgc tta ggg gtc         48
Met Gly Trp Leu Pro Leu Leu Leu Leu Leu Thr Gln Cys Leu Gly Val           
1               5                   10                  15                

cct ggg cag cgc tcg cca ttg aat gac ttc caa gtg ctc cgg ggc aca         96
Pro Gly Gln Arg Ser Pro Leu Asn Asp Phe Gln Val Leu Arg Gly Thr           
            20                  25                  30                    

gag cta cag cac ctg cta cat gcg gtg gtg ccc ggg cct tgg cag gag        144
Glu Leu Gln His Leu Leu His Ala Val Val Pro Gly Pro Trp Gln Glu           
        35                  40                  45                        

gat gtg gca gat gct gaa gag tgt gct ggt cgc tgt ggg ccc tta atg        192
Asp Val Ala Asp Ala Glu Glu Cys Ala Gly Arg Cys Gly Pro Leu Met           
    50                  55                  60                            

gac tgc cgg gcc ttc cac tac aac gtg agc agc cat ggt tgc caa ctg        240
Asp Cys Arg Ala Phe His Tyr Asn Val Ser Ser His Gly Cys Gln Leu           
65                  70                  75                  80            

ctg cca tgg act caa cac tcg ccc cac acg agg ctg cgg cgt tct ggg        288
Leu Pro Trp Thr Gln His Ser Pro His Thr Arg Leu Arg Arg Ser Gly           
                85                  90                  95                

cgc tgt gac ctc ttc cag aag aaa gac tac gta cgg acc tgc atc atg        336
Arg Cys Asp Leu Phe Gln Lys Lys Asp Tyr Val Arg Thr Cys Ile Met           
            100                 105                 110                   

aac aat ggg gtt ggg tac cgg ggc acc atg gcc acg acc gtg ggt ggc        384
Asn Asn Gly Val Gly Tyr Arg Gly Thr Met Ala Thr Thr Val Gly Gly           
        115                 120                 125                       

ctg ccc tgc cag gct tgg agc cac aag ttc ccg aat gat cac aag tac        432
Leu Pro Cys Gln Ala Trp Ser His Lys Phe Pro Asn Asp His Lys Tyr           
    130                 135                 140                           

acg ccc act ctc cgg aat ggc ctg gaa gag aac ttc tgc cgt aac cct        480
Thr Pro Thr Leu Arg Asn Gly Leu Glu Glu Asn Phe Cys Arg Asn Pro           
145                 150                 155                 160           

gat ggc gac ccc gga ggt cct tgg tgc tac aca aca gac cct gct gtg        528
Asp Gly Asp Pro Gly Gly Pro Trp Cys Tyr Thr Thr Asp Pro Ala Val           
                165                 170                 175               

cgc ttc cag agc tgc ggc atc aaa tcc tgc cgg gag gcc gcg tgt gtc        576
Arg Phe Gln Ser Cys Gly Ile Lys Ser Cys Arg Glu Ala Ala Cys Val           
            180                 185                 190                   

tgg tgc aat ggc gag gaa tac cgc ggc gcg gta gac cgc acg gag tca        624
Trp Cys Asn Gly Glu Glu Tyr Arg Gly Ala Val Asp Arg Thr Glu Ser           
        195                 200                 205                       

ggg cgc gag tgc cag cgc tgg gat ctt cag cac ccg cac cag cac ccc        672
Gly Arg Glu Cys Gln Arg Trp Asp Leu Gln His Pro His Gln His Pro           
    210                 215                 220                           

ttc gag ccg ggc aag ttc ctc gac caa ggt ctg gac gac aac tat tgc        720
Phe Glu Pro Gly Lys Phe Leu Asp Gln Gly Leu Asp Asp Asn Tyr Cys           
225                 230                 235                 240           

cgg aat cct gac ggc tcc gag cgg cca tgg tgc tac act acg gat ccg        768
Arg Asn Pro Asp Gly Ser Glu Arg Pro Trp Cys Tyr Thr Thr Asp Pro           
                245                 250                 255               

cag atc gag cga gag ttc tgt gac ctc ccc cgc tgc ggg tcc gag gca        816
Gln Ile Glu Arg Glu Phe Cys Asp Leu Pro Arg Cys Gly Ser Glu Ala           
            260                 265                 270                   

cag ccc cgc caa gag gcc aca act gtc agc tgc ttc cgc ggg aag ggt        864
Gln Pro Arg Gln Glu Ala Thr Thr Val Ser Cys Phe Arg Gly Lys Gly           
        275                 280                 285                       

gag ggc tac cgg ggc aca gcc aat acc acc act gcg ggc gta cct tgc        912
Glu Gly Tyr Arg Gly Thr Ala Asn Thr Thr Thr Ala Gly Val Pro Cys           
    290                 295                 300                           

cag cgt tgg gac gcg caa atc cct cat cag cac cga ttt acg cca gaa        960
Gln Arg Trp Asp Ala Gln Ile Pro His Gln His Arg Phe Thr Pro Glu           
305                 310                 315                 320           

aaa tac gcg tgc aaa gac ctt cgg gag aac ttc tgc cgg aac ccc gac       1008
Lys Tyr Ala Cys Lys Asp Leu Arg Glu Asn Phe Cys Arg Asn Pro Asp           
                325                 330                 335               

ggc tca gag gcg ccc tgg tgc ttc aca ctg cgg ccc ggc atg cgc gcg       1056
Gly Ser Glu Ala Pro Trp Cys Phe Thr Leu Arg Pro Gly Met Arg Ala           
            340                 345                 350                   

gcc ttt tgc tac cag atc cgg cgt tgt aca gac gac gtg cgg ccc cag       1104
Ala Phe Cys Tyr Gln Ile Arg Arg Cys Thr Asp Asp Val Arg Pro Gln           
        355                 360                 365                       

gac tgc tac cac ggc gca ggg gag cag tac cgc ggc acg gtc agc aag       1152
Asp Cys Tyr His Gly Ala Gly Glu Gln Tyr Arg Gly Thr Val Ser Lys           
    370                 375                 380                           

acc cgc aag ggt gtc cag tgc cag cgc tgg tcc gct gag acg ccg cac       1200
Thr Arg Lys Gly Val Gln Cys Gln Arg Trp Ser Ala Glu Thr Pro His           
385                 390                 395                 400           

aag ccg cag ttc acg ttt acc tcc gaa ccg cat gca caa ctg gag gag       1248
Lys Pro Gln Phe Thr Phe Thr Ser Glu Pro His Ala Gln Leu Glu Glu           
                405                 410                 415               

aac ttc tgc cgg aac cca gat ggg gat agc cat ggg ccc tgg tgc tac       1296
Asn Phe Cys Arg Asn Pro Asp Gly Asp Ser His Gly Pro Trp Cys Tyr           
            420                 425                 430                   

acg atg gac cca agg acc cca ttc gac tac tgt gcc ctg cga cgc tgc       1344
Thr Met Asp Pro Arg Thr Pro Phe Asp Tyr Cys Ala Leu Arg Arg Cys           
        435                 440                 445                       

gct gat gac cag ccg cca tca atc ctg gac ccc cca gac cag gtg cag       1392
Ala Asp Asp Gln Pro Pro Ser Ile Leu Asp Pro Pro Asp Gln Val Gln           
    450                 455                 460                           

ttt gag aag tgt ggc aag agg gtg gat cgg ctg gat cag cgg cgt tcc       1440
Phe Glu Lys Cys Gly Lys Arg Val Asp Arg Leu Asp Gln Arg Arg Ser           
465                 470                 475                 480           

aag ctg cgc gtg gtt ggg ggc cat ccg ggc aac tca ccc tgg aca gtc       1488
Lys Leu Arg Val Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val           
                485                 490                 495               

agc ttg cgg aat cgg cag ggc cag cat ttc tgc ggg ggg tct cta gtg       1536
Ser Leu Arg Asn Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val           
            500                 505                 510                   

aag gag cag tgg ata ctg act gcc cgg cag tgc ttc tcc tcc tgc cat       1584
Lys Glu Gln Trp Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser Cys His           
        515                 520                 525                       

atg cct ctc acg ggc tat gag gta tgg ttg ggc acc ctg ttc cag aac       1632
Met Pro Leu Thr Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe Gln Asn           
    530                 535                 540                           

cca cag cat gga gag cca agc cta cag cgg gtc cca gta gcc aag atg       1680
Pro Gln His Gly Glu Pro Ser Leu Gln Arg Val Pro Val Ala Lys Met           
545                 550                 555                 560           

gtg tgt ggg ccc tca ggc tcc cag ctt gtc ctg ctc aag ctg gag aga       1728
Val Cys Gly Pro Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg           
                565                 570                 575               

tct gtg acc ctg aac cag cgt gtg gcc ctg atc tgc ctg ccc cct gaa       1776
Ser Val Thr Leu Asn Gln Arg Val Ala Leu Ile Cys Leu Pro Pro Glu           
            580                 585                 590                   

tgg tat gtg gtg cct cca ggg acc aag tgt gag att gca ggc tgg ggt       1824
Trp Tyr Val Val Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly           
        595                 600                 605                       

gag acc aaa ggt acg ggt aat gac aca gtc cta aat gtg gcc ttg ctg       1872
Glu Thr Lys Gly Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu           
    610                 615                 620                           

aat gtc atc tcc aac cag gag tgt aac atc aag cac cga gga cgt gtg       1920
Asn Val Ile Ser Asn Gln Glu Cys Asn Ile Lys His Arg Gly Arg Val           
625                 630                 635                 640           

cgg gag agt gag atg tgc act gag gga ctg ttg gcc cct gtg ggg gcc       1968
Arg Glu Ser Glu Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly Ala           
                645                 650                 655               

tgt gag ggt gac tac ggg ggc cca ctt gcc tgc ttt acc cac aac gcc       2016
Cys Glu Gly Asp Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn Ala           
            660                 665                 670                   

tgg gtc ctg gaa gga att ata atc ccc aac cga gta tgc gca agg tcc       2064
Trp Val Leu Glu Gly Ile Ile Ile Pro Asn Arg Val Cys Ala Arg Ser           
        675                 680                 685                       

cgc tgg cca gct gtc ttc acg cgt gtc tct gtg ttt gtg gac tgg att       2112
Arg Trp Pro Ala Val Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile           
    690                 695                 700                           

cac aag gtc atg aga ctg ggt cat cat cat cat cat cat cat cat tga       2160
His Lys Val Met Arg Leu Gly His His His His His His His His               
705                 710                 715                               


<210>  2
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Gly Trp Leu Pro Leu Leu Leu Leu Leu Thr Gln Cys Leu Gly Val 
1               5                   10                  15      


Pro Gly Gln Arg Ser Pro Leu Asn Asp Phe Gln Val Leu Arg Gly Thr 
            20                  25                  30          


Glu Leu Gln His Leu Leu His Ala Val Val Pro Gly Pro Trp Gln Glu 
        35                  40                  45              


Asp Val Ala Asp Ala Glu Glu Cys Ala Gly Arg Cys Gly Pro Leu Met 
    50                  55                  60                  


Asp Cys Arg Ala Phe His Tyr Asn Val Ser Ser His Gly Cys Gln Leu 
65                  70                  75                  80  


Leu Pro Trp Thr Gln His Ser Pro His Thr Arg Leu Arg Arg Ser Gly 
                85                  90                  95      


Arg Cys Asp Leu Phe Gln Lys Lys Asp Tyr Val Arg Thr Cys Ile Met 
            100                 105                 110         


Asn Asn Gly Val Gly Tyr Arg Gly Thr Met Ala Thr Thr Val Gly Gly 
        115                 120                 125             


Leu Pro Cys Gln Ala Trp Ser His Lys Phe Pro Asn Asp His Lys Tyr 
    130                 135                 140                 


Thr Pro Thr Leu Arg Asn Gly Leu Glu Glu Asn Phe Cys Arg Asn Pro 
145                 150                 155                 160 


Asp Gly Asp Pro Gly Gly Pro Trp Cys Tyr Thr Thr Asp Pro Ala Val 
                165                 170                 175     


Arg Phe Gln Ser Cys Gly Ile Lys Ser Cys Arg Glu Ala Ala Cys Val 
            180                 185                 190         


Trp Cys Asn Gly Glu Glu Tyr Arg Gly Ala Val Asp Arg Thr Glu Ser 
        195                 200                 205             


Gly Arg Glu Cys Gln Arg Trp Asp Leu Gln His Pro His Gln His Pro 
    210                 215                 220                 


Phe Glu Pro Gly Lys Phe Leu Asp Gln Gly Leu Asp Asp Asn Tyr Cys 
225                 230                 235                 240 


Arg Asn Pro Asp Gly Ser Glu Arg Pro Trp Cys Tyr Thr Thr Asp Pro 
                245                 250                 255     


Gln Ile Glu Arg Glu Phe Cys Asp Leu Pro Arg Cys Gly Ser Glu Ala 
            260                 265                 270         


Gln Pro Arg Gln Glu Ala Thr Thr Val Ser Cys Phe Arg Gly Lys Gly 
        275                 280                 285             


Glu Gly Tyr Arg Gly Thr Ala Asn Thr Thr Thr Ala Gly Val Pro Cys 
    290                 295                 300                 


Gln Arg Trp Asp Ala Gln Ile Pro His Gln His Arg Phe Thr Pro Glu 
305                 310                 315                 320 


Lys Tyr Ala Cys Lys Asp Leu Arg Glu Asn Phe Cys Arg Asn Pro Asp 
                325                 330                 335     


Gly Ser Glu Ala Pro Trp Cys Phe Thr Leu Arg Pro Gly Met Arg Ala 
            340                 345                 350         


Ala Phe Cys Tyr Gln Ile Arg Arg Cys Thr Asp Asp Val Arg Pro Gln 
        355                 360                 365             


Asp Cys Tyr His Gly Ala Gly Glu Gln Tyr Arg Gly Thr Val Ser Lys 
    370                 375                 380                 


Thr Arg Lys Gly Val Gln Cys Gln Arg Trp Ser Ala Glu Thr Pro His 
385                 390                 395                 400 


Lys Pro Gln Phe Thr Phe Thr Ser Glu Pro His Ala Gln Leu Glu Glu 
                405                 410                 415     


Asn Phe Cys Arg Asn Pro Asp Gly Asp Ser His Gly Pro Trp Cys Tyr 
            420                 425                 430         


Thr Met Asp Pro Arg Thr Pro Phe Asp Tyr Cys Ala Leu Arg Arg Cys 
        435                 440                 445             


Ala Asp Asp Gln Pro Pro Ser Ile Leu Asp Pro Pro Asp Gln Val Gln 
    450                 455                 460                 


Phe Glu Lys Cys Gly Lys Arg Val Asp Arg Leu Asp Gln Arg Arg Ser 
465                 470                 475                 480 


Lys Leu Arg Val Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val 
                485                 490                 495     


Ser Leu Arg Asn Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val 
            500                 505                 510         


Lys Glu Gln Trp Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser Cys His 
        515                 520                 525             


Met Pro Leu Thr Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe Gln Asn 
    530                 535                 540                 


Pro Gln His Gly Glu Pro Ser Leu Gln Arg Val Pro Val Ala Lys Met 
545                 550                 555                 560 


Val Cys Gly Pro Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg 
                565                 570                 575     


Ser Val Thr Leu Asn Gln Arg Val Ala Leu Ile Cys Leu Pro Pro Glu 
            580                 585                 590         


Trp Tyr Val Val Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly 
        595                 600                 605             


Glu Thr Lys Gly Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu 
    610                 615                 620                 


Asn Val Ile Ser Asn Gln Glu Cys Asn Ile Lys His Arg Gly Arg Val 
625                 630                 635                 640 


Arg Glu Ser Glu Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly Ala 
                645                 650                 655     


Cys Glu Gly Asp Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn Ala 
            660                 665                 670         


Trp Val Leu Glu Gly Ile Ile Ile Pro Asn Arg Val Cys Ala Arg Ser 
        675                 680                 685             


Arg Trp Pro Ala Val Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile 
    690                 695                 700                 


His Lys Val Met Arg Leu Gly His His His His His His His His 
705                 710                 715                 


<210>  3
<211>  2160
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(2160)

<400>  3
atg ggg tgg ctc cca ctc ctg ctg ctt ctg act caa tgc tta ggg gtc         48
Met Gly Trp Leu Pro Leu Leu Leu Leu Leu Thr Gln Cys Leu Gly Val           
1               5                   10                  15                

cct ggg cag cgc tcg cca ttg aat gac ttc caa gtg ctc cgg ggc aca         96
Pro Gly Gln Arg Ser Pro Leu Asn Asp Phe Gln Val Leu Arg Gly Thr           
            20                  25                  30                    

gag cta cag cac ctg cta cat gcg gtg gtg ccc ggg cct tgg cag gag        144
Glu Leu Gln His Leu Leu His Ala Val Val Pro Gly Pro Trp Gln Glu           
        35                  40                  45                        

gat gtg gca gat gct gaa gag tgt gct ggt cgc tgt ggg ccc tta atg        192
Asp Val Ala Asp Ala Glu Glu Cys Ala Gly Arg Cys Gly Pro Leu Met           
    50                  55                  60                            

gac tgc cgg gcc ttc cac tac aac gtg agc agc cat ggt tgc caa ctg        240
Asp Cys Arg Ala Phe His Tyr Asn Val Ser Ser His Gly Cys Gln Leu           
65                  70                  75                  80            

ctg cca tgg act caa cac tcg ccc cac acg agg ctg cgg cgt tct ggg        288
Leu Pro Trp Thr Gln His Ser Pro His Thr Arg Leu Arg Arg Ser Gly           
                85                  90                  95                

cgc tgt gac ctc ttc cag aag aaa gac tac gta cgg acc tgc atc atg        336
Arg Cys Asp Leu Phe Gln Lys Lys Asp Tyr Val Arg Thr Cys Ile Met           
            100                 105                 110                   

aac aat ggg gtt ggg tac cgg ggc acc atg gcc acg acc gtg ggt ggc        384
Asn Asn Gly Val Gly Tyr Arg Gly Thr Met Ala Thr Thr Val Gly Gly           
        115                 120                 125                       

ctg ccc tgc cag gct tgg agc cac aag ttc ccg aat gat cac aag tac        432
Leu Pro Cys Gln Ala Trp Ser His Lys Phe Pro Asn Asp His Lys Tyr           
    130                 135                 140                           

acg ccc act ctc cgg aat ggc ctg gaa gag aac ttc tgc cgt aac cct        480
Thr Pro Thr Leu Arg Asn Gly Leu Glu Glu Asn Phe Cys Arg Asn Pro           
145                 150                 155                 160           

gat ggc gac ccc gga ggt cct tgg tgc tac aca aca gac cct gct gtg        528
Asp Gly Asp Pro Gly Gly Pro Trp Cys Tyr Thr Thr Asp Pro Ala Val           
                165                 170                 175               

cgc ttc cag agc tgc ggc atc aaa tcc tgc cgg gag gcc gcg tgt gtc        576
Arg Phe Gln Ser Cys Gly Ile Lys Ser Cys Arg Glu Ala Ala Cys Val           
            180                 185                 190                   

tgg tgc aat ggc gag gaa tac cgc ggc gcg gta gac cgc acg gag tca        624
Trp Cys Asn Gly Glu Glu Tyr Arg Gly Ala Val Asp Arg Thr Glu Ser           
        195                 200                 205                       

ggg cgc gag tgc cag cgc tgg gat ctt cag cac ccg cac cag cac ccc        672
Gly Arg Glu Cys Gln Arg Trp Asp Leu Gln His Pro His Gln His Pro           
    210                 215                 220                           

ttc gag ccg ggc aag ttc ctc gac caa ggt ctg gac gac aac tat tgc        720
Phe Glu Pro Gly Lys Phe Leu Asp Gln Gly Leu Asp Asp Asn Tyr Cys           
225                 230                 235                 240           

cgg aat cct gac ggc tcc gag cgg cca tgg tgc tac act acg gat ccg        768
Arg Asn Pro Asp Gly Ser Glu Arg Pro Trp Cys Tyr Thr Thr Asp Pro           
                245                 250                 255               

cag atc gag cga gag ttc tgt gac ctc ccc cgc tgc ggg tcc gag gca        816
Gln Ile Glu Arg Glu Phe Cys Asp Leu Pro Arg Cys Gly Ser Glu Ala           
            260                 265                 270                   

cag ccc cgc caa gag gcc aca act gtc agc tgc ttc cgc ggg aag ggt        864
Gln Pro Arg Gln Glu Ala Thr Thr Val Ser Cys Phe Arg Gly Lys Gly           
        275                 280                 285                       

gag ggc tac cgg ggc aca gcc aat acc acc act gcg ggc gta cct tgc        912
Glu Gly Tyr Arg Gly Thr Ala Asn Thr Thr Thr Ala Gly Val Pro Cys           
    290                 295                 300                           

cag cgt tgg gac gcg caa atc cct cat cag cac cga ttt acg cca gaa        960
Gln Arg Trp Asp Ala Gln Ile Pro His Gln His Arg Phe Thr Pro Glu           
305                 310                 315                 320           

aaa tac gcg tgc aaa gac ctt cgg gag aac ttc tgc cgg aac ccc gac       1008
Lys Tyr Ala Cys Lys Asp Leu Arg Glu Asn Phe Cys Arg Asn Pro Asp           
                325                 330                 335               

ggc tca gag gcg ccc tgg tgc ttc aca ctg cgg ccc ggc atg cgc gcg       1056
Gly Ser Glu Ala Pro Trp Cys Phe Thr Leu Arg Pro Gly Met Arg Ala           
            340                 345                 350                   

gcc ttt tgc tac cag atc cgg cgt tgt aca gac gac gtg cgg ccc cag       1104
Ala Phe Cys Tyr Gln Ile Arg Arg Cys Thr Asp Asp Val Arg Pro Gln           
        355                 360                 365                       

gac tgc tac cac ggc gca ggg gag cag tac cgc ggc acg gtc agc aag       1152
Asp Cys Tyr His Gly Ala Gly Glu Gln Tyr Arg Gly Thr Val Ser Lys           
    370                 375                 380                           

acc cgc aag ggt gtc cag tgc cag cgc tgg tcc gct gag acg ccg cac       1200
Thr Arg Lys Gly Val Gln Cys Gln Arg Trp Ser Ala Glu Thr Pro His           
385                 390                 395                 400           

aag ccg cag ttc acg ttt acc tcc gaa ccg cat gca caa ctg gag gag       1248
Lys Pro Gln Phe Thr Phe Thr Ser Glu Pro His Ala Gln Leu Glu Glu           
                405                 410                 415               

aac ttc tgc cgg aac cca gat ggg gat agc cat ggg ccc tgg tgc tac       1296
Asn Phe Cys Arg Asn Pro Asp Gly Asp Ser His Gly Pro Trp Cys Tyr           
            420                 425                 430                   

acg atg gac cca agg acc cca ttc gac tac tgt gcc ctg cga cgc tgc       1344
Thr Met Asp Pro Arg Thr Pro Phe Asp Tyr Cys Ala Leu Arg Arg Cys           
        435                 440                 445                       

gct gat gac cag ccg cca tca atc ctg gac ccc cca gac cag gtg cag       1392
Ala Asp Asp Gln Pro Pro Ser Ile Leu Asp Pro Pro Asp Gln Val Gln           
    450                 455                 460                           

ttt gag aag tgt ggc aag agg gtg gat cgg ctg gat cag cgg cgt tcc       1440
Phe Glu Lys Cys Gly Lys Arg Val Asp Arg Leu Asp Gln Arg Arg Ser           
465                 470                 475                 480           

aag ctg cgc gtg gtt ggg ggc cat ccg ggc aac tca ccc tgg aca gtc       1488
Lys Leu Arg Val Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val           
                485                 490                 495               

agc ttg cgg aat cgg cag ggc cag cat ttc tgc ggg ggg tct cta gtg       1536
Ser Leu Arg Asn Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val           
            500                 505                 510                   

aag gag cag tgg ata ctg act gcc cgg cag tgc ttc tcc tcc tgc cat       1584
Lys Glu Gln Trp Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser Cys His           
        515                 520                 525                       

atg cct ctc acg ggc tat gag gta tgg ttg ggc acc ctg ttc cag aac       1632
Met Pro Leu Thr Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe Gln Asn           
    530                 535                 540                           

cca cag cat gga gag cca agc cta cag cgg gtc cca gta gcc aag atg       1680
Pro Gln His Gly Glu Pro Ser Leu Gln Arg Val Pro Val Ala Lys Met           
545                 550                 555                 560           

gtg tgt ggg ccc tca ggc tcc cag ctt gtc ctg ctc aag ctg gag aga       1728
Val Cys Gly Pro Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg           
                565                 570                 575               

tct gtg acc ctg aac cag cgt gtg gcc ctg atc tgc ctg ccc cct gaa       1776
Ser Val Thr Leu Asn Gln Arg Val Ala Leu Ile Cys Leu Pro Pro Glu           
            580                 585                 590                   

tgg tat gtg gtg cct cca ggg acc aag tgt gag att gca ggc tgg ggt       1824
Trp Tyr Val Val Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly           
        595                 600                 605                       

gag acc aaa ggt acg ggt aat gac aca gtc cta aat gtg gcc ttg ctg       1872
Glu Thr Lys Gly Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu           
    610                 615                 620                           

aat gtc atc tcc aac cag gag tgt aac atc aag cac cga gga cgt gtg       1920
Asn Val Ile Ser Asn Gln Glu Cys Asn Ile Lys His Arg Gly Arg Val           
625                 630                 635                 640           

cgg gag agt gag atg tgc act gag gga ctg ttg gcc cct gtg ggg gcc       1968
Arg Glu Ser Glu Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly Ala           
                645                 650                 655               

tgt gag ggt gac tac ggg ggc cca ctt gcc tgc ttt acc cac aac gcc       2016
Cys Glu Gly Asp Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn Ala           
            660                 665                 670                   

tgg gtc ctg gaa gga att ata atc ccc aac cga gta tgc gca agg tcc       2064
Trp Val Leu Glu Gly Ile Ile Ile Pro Asn Arg Val Cys Ala Arg Ser           
        675                 680                 685                       

tgc tgg cca gct gtc ttc acg cgt gtc tct gtg ttt gtg gac tgg att       2112
Cys Trp Pro Ala Val Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile           
    690                 695                 700                           

cac aag gtc atg aga ctg ggt cat cat cat cat cat cat cat cat tga       2160
His Lys Val Met Arg Leu Gly His His His His His His His His               
705                 710                 715                               


<210>  4
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Gly Trp Leu Pro Leu Leu Leu Leu Leu Thr Gln Cys Leu Gly Val 
1               5                   10                  15      


Pro Gly Gln Arg Ser Pro Leu Asn Asp Phe Gln Val Leu Arg Gly Thr 
            20                  25                  30          


Glu Leu Gln His Leu Leu His Ala Val Val Pro Gly Pro Trp Gln Glu 
        35                  40                  45              


Asp Val Ala Asp Ala Glu Glu Cys Ala Gly Arg Cys Gly Pro Leu Met 
    50                  55                  60                  


Asp Cys Arg Ala Phe His Tyr Asn Val Ser Ser His Gly Cys Gln Leu 
65                  70                  75                  80  


Leu Pro Trp Thr Gln His Ser Pro His Thr Arg Leu Arg Arg Ser Gly 
                85                  90                  95      


Arg Cys Asp Leu Phe Gln Lys Lys Asp Tyr Val Arg Thr Cys Ile Met 
            100                 105                 110         


Asn Asn Gly Val Gly Tyr Arg Gly Thr Met Ala Thr Thr Val Gly Gly 
        115                 120                 125             


Leu Pro Cys Gln Ala Trp Ser His Lys Phe Pro Asn Asp His Lys Tyr 
    130                 135                 140                 


Thr Pro Thr Leu Arg Asn Gly Leu Glu Glu Asn Phe Cys Arg Asn Pro 
145                 150                 155                 160 


Asp Gly Asp Pro Gly Gly Pro Trp Cys Tyr Thr Thr Asp Pro Ala Val 
                165                 170                 175     


Arg Phe Gln Ser Cys Gly Ile Lys Ser Cys Arg Glu Ala Ala Cys Val 
            180                 185                 190         


Trp Cys Asn Gly Glu Glu Tyr Arg Gly Ala Val Asp Arg Thr Glu Ser 
        195                 200                 205             


Gly Arg Glu Cys Gln Arg Trp Asp Leu Gln His Pro His Gln His Pro 
    210                 215                 220                 


Phe Glu Pro Gly Lys Phe Leu Asp Gln Gly Leu Asp Asp Asn Tyr Cys 
225                 230                 235                 240 


Arg Asn Pro Asp Gly Ser Glu Arg Pro Trp Cys Tyr Thr Thr Asp Pro 
                245                 250                 255     


Gln Ile Glu Arg Glu Phe Cys Asp Leu Pro Arg Cys Gly Ser Glu Ala 
            260                 265                 270         


Gln Pro Arg Gln Glu Ala Thr Thr Val Ser Cys Phe Arg Gly Lys Gly 
        275                 280                 285             


Glu Gly Tyr Arg Gly Thr Ala Asn Thr Thr Thr Ala Gly Val Pro Cys 
    290                 295                 300                 


Gln Arg Trp Asp Ala Gln Ile Pro His Gln His Arg Phe Thr Pro Glu 
305                 310                 315                 320 


Lys Tyr Ala Cys Lys Asp Leu Arg Glu Asn Phe Cys Arg Asn Pro Asp 
                325                 330                 335     


Gly Ser Glu Ala Pro Trp Cys Phe Thr Leu Arg Pro Gly Met Arg Ala 
            340                 345                 350         


Ala Phe Cys Tyr Gln Ile Arg Arg Cys Thr Asp Asp Val Arg Pro Gln 
        355                 360                 365             


Asp Cys Tyr His Gly Ala Gly Glu Gln Tyr Arg Gly Thr Val Ser Lys 
    370                 375                 380                 


Thr Arg Lys Gly Val Gln Cys Gln Arg Trp Ser Ala Glu Thr Pro His 
385                 390                 395                 400 


Lys Pro Gln Phe Thr Phe Thr Ser Glu Pro His Ala Gln Leu Glu Glu 
                405                 410                 415     


Asn Phe Cys Arg Asn Pro Asp Gly Asp Ser His Gly Pro Trp Cys Tyr 
            420                 425                 430         


Thr Met Asp Pro Arg Thr Pro Phe Asp Tyr Cys Ala Leu Arg Arg Cys 
        435                 440                 445             


Ala Asp Asp Gln Pro Pro Ser Ile Leu Asp Pro Pro Asp Gln Val Gln 
    450                 455                 460                 


Phe Glu Lys Cys Gly Lys Arg Val Asp Arg Leu Asp Gln Arg Arg Ser 
465                 470                 475                 480 


Lys Leu Arg Val Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val 
                485                 490                 495     


Ser Leu Arg Asn Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val 
            500                 505                 510         


Lys Glu Gln Trp Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser Cys His 
        515                 520                 525             


Met Pro Leu Thr Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe Gln Asn 
    530                 535                 540                 


Pro Gln His Gly Glu Pro Ser Leu Gln Arg Val Pro Val Ala Lys Met 
545                 550                 555                 560 


Val Cys Gly Pro Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg 
                565                 570                 575     


Ser Val Thr Leu Asn Gln Arg Val Ala Leu Ile Cys Leu Pro Pro Glu 
            580                 585                 590         


Trp Tyr Val Val Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly 
        595                 600                 605             


Glu Thr Lys Gly Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu 
    610                 615                 620                 


Asn Val Ile Ser Asn Gln Glu Cys Asn Ile Lys His Arg Gly Arg Val 
625                 630                 635                 640 


Arg Glu Ser Glu Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly Ala 
                645                 650                 655     


Cys Glu Gly Asp Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn Ala 
            660                 665                 670         


Trp Val Leu Glu Gly Ile Ile Ile Pro Asn Arg Val Cys Ala Arg Ser 
        675                 680                 685             


Cys Trp Pro Ala Val Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile 
    690                 695                 700                 


His Lys Val Met Arg Leu Gly His His His His His His His His 
705                 710                 715                 


<210>  5
<211>  2154
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(2154)

<400>  5
atg ggg tgg ctc cca ctc ctg ctg ctt ctg act caa tgc tta ggg gtc         48
Met Gly Trp Leu Pro Leu Leu Leu Leu Leu Thr Gln Cys Leu Gly Val           
1               5                   10                  15                

cct ggg cag cgc tcg cca ttg aat gac ttc caa gtg ctc cgg ggc aca         96
Pro Gly Gln Arg Ser Pro Leu Asn Asp Phe Gln Val Leu Arg Gly Thr           
            20                  25                  30                    

gag cta cag cac ctg cta cat gcg gtg gtg ccc ggg cct tgg cag gag        144
Glu Leu Gln His Leu Leu His Ala Val Val Pro Gly Pro Trp Gln Glu           
        35                  40                  45                        

gat gtg gca gat gct gaa gag tgt gct ggt cgc tgt ggg ccc tta atg        192
Asp Val Ala Asp Ala Glu Glu Cys Ala Gly Arg Cys Gly Pro Leu Met           
    50                  55                  60                            

gac tgc cgg gcc ttc cac tac aac gtg agc agc cat ggt tgc caa ctg        240
Asp Cys Arg Ala Phe His Tyr Asn Val Ser Ser His Gly Cys Gln Leu           
65                  70                  75                  80            

ctg cca tgg act caa cac tcg ccc cac acg agg ctg cgg cgt tct ggg        288
Leu Pro Trp Thr Gln His Ser Pro His Thr Arg Leu Arg Arg Ser Gly           
                85                  90                  95                

cgc tgt gac ctc ttc cag aag aaa gac tac gta cgg acc tgc atc atg        336
Arg Cys Asp Leu Phe Gln Lys Lys Asp Tyr Val Arg Thr Cys Ile Met           
            100                 105                 110                   

aac aat ggg gtt ggg tac cgg ggc acc atg gcc acg acc gtg ggt ggc        384
Asn Asn Gly Val Gly Tyr Arg Gly Thr Met Ala Thr Thr Val Gly Gly           
        115                 120                 125                       

ctg ccc tgc cag gct tgg agc cac aag ttc ccg aat gat cac aag tac        432
Leu Pro Cys Gln Ala Trp Ser His Lys Phe Pro Asn Asp His Lys Tyr           
    130                 135                 140                           

acg ccc act ctc cgg aat ggc ctg gaa gag aac ttc tgc cgt aac cct        480
Thr Pro Thr Leu Arg Asn Gly Leu Glu Glu Asn Phe Cys Arg Asn Pro           
145                 150                 155                 160           

gat ggc gac ccc gga ggt cct tgg tgc tac aca aca gac cct gct gtg        528
Asp Gly Asp Pro Gly Gly Pro Trp Cys Tyr Thr Thr Asp Pro Ala Val           
                165                 170                 175               

cgc ttc cag agc tgc ggc atc aaa tcc tgc cgg gag gcc gcg tgt gtc        576
Arg Phe Gln Ser Cys Gly Ile Lys Ser Cys Arg Glu Ala Ala Cys Val           
            180                 185                 190                   

tgg tgc aat ggc gag gaa tac cgc ggc gcg gta gac cgc acg gag tca        624
Trp Cys Asn Gly Glu Glu Tyr Arg Gly Ala Val Asp Arg Thr Glu Ser           
        195                 200                 205                       

ggg cgc gag tgc cag cgc tgg gat ctt cag cac ccg cac cag cac ccc        672
Gly Arg Glu Cys Gln Arg Trp Asp Leu Gln His Pro His Gln His Pro           
    210                 215                 220                           

ttc gag ccg ggc aag ttc ctc gac caa ggt ctg gac gac aac tat tgc        720
Phe Glu Pro Gly Lys Phe Leu Asp Gln Gly Leu Asp Asp Asn Tyr Cys           
225                 230                 235                 240           

cgg aat cct gac ggc tcc gag cgg cca tgg tgc tac act acg gat ccg        768
Arg Asn Pro Asp Gly Ser Glu Arg Pro Trp Cys Tyr Thr Thr Asp Pro           
                245                 250                 255               

cag atc gag cga gag ttc tgt gac ctc ccc cgc tgc ggg tcc gag gca        816
Gln Ile Glu Arg Glu Phe Cys Asp Leu Pro Arg Cys Gly Ser Glu Ala           
            260                 265                 270                   

cag ccc cgc caa gag gcc aca act gtc agc tgc ttc cgc ggg aag ggt        864
Gln Pro Arg Gln Glu Ala Thr Thr Val Ser Cys Phe Arg Gly Lys Gly           
        275                 280                 285                       

gag ggc tac cgg ggc aca gcc aat acc acc act gcg ggc gta cct tgc        912
Glu Gly Tyr Arg Gly Thr Ala Asn Thr Thr Thr Ala Gly Val Pro Cys           
    290                 295                 300                           

cag cgt tgg gac gcg caa atc cct cat cag cac cga ttt acg cca gaa        960
Gln Arg Trp Asp Ala Gln Ile Pro His Gln His Arg Phe Thr Pro Glu           
305                 310                 315                 320           

aaa tac gcg tgc aaa gac ctt cgg gag aac ttc tgc cgg aac ccc gac       1008
Lys Tyr Ala Cys Lys Asp Leu Arg Glu Asn Phe Cys Arg Asn Pro Asp           
                325                 330                 335               

ggc tca gag gcg ccc tgg tgc ttc aca ctg cgg ccc ggc atg cgc gcg       1056
Gly Ser Glu Ala Pro Trp Cys Phe Thr Leu Arg Pro Gly Met Arg Ala           
            340                 345                 350                   

gcc ttt tgc tac cag atc cgg cgt tgt aca gac gac gtg cgg ccc cag       1104
Ala Phe Cys Tyr Gln Ile Arg Arg Cys Thr Asp Asp Val Arg Pro Gln           
        355                 360                 365                       

gac tgc tac cac ggc gca ggg gag cag tac cgc ggc acg gtc agc aag       1152
Asp Cys Tyr His Gly Ala Gly Glu Gln Tyr Arg Gly Thr Val Ser Lys           
    370                 375                 380                           

acc cgc aag ggt gtc cag tgc cag cgc tgg tcc gct gag acg ccg cac       1200
Thr Arg Lys Gly Val Gln Cys Gln Arg Trp Ser Ala Glu Thr Pro His           
385                 390                 395                 400           

aag ccg cag ttc acg ttt acc tcc gaa ccg cat gca caa ctg gag gag       1248
Lys Pro Gln Phe Thr Phe Thr Ser Glu Pro His Ala Gln Leu Glu Glu           
                405                 410                 415               

aac ttc tgc cgg aac cca gat ggg gat agc cat ggg ccc tgg tgc tac       1296
Asn Phe Cys Arg Asn Pro Asp Gly Asp Ser His Gly Pro Trp Cys Tyr           
            420                 425                 430                   

acg atg gac cca agg acc cca ttc gac tac tgt gcc ctg cga cgc tgc       1344
Thr Met Asp Pro Arg Thr Pro Phe Asp Tyr Cys Ala Leu Arg Arg Cys           
        435                 440                 445                       

gct gat gac cag ccg cca tca atc ctg gac ccc cca gac cag gtg cag       1392
Ala Asp Asp Gln Pro Pro Ser Ile Leu Asp Pro Pro Asp Gln Val Gln           
    450                 455                 460                           

ttt gag aag tgt ggc aag agg gtg gat cgg ctg gat cag cgg cgt tcc       1440
Phe Glu Lys Cys Gly Lys Arg Val Asp Arg Leu Asp Gln Arg Arg Ser           
465                 470                 475                 480           

aag ctg gaa gtg gtt ggg ggc cat ccg ggc aac tca ccc tgg aca gtc       1488
Lys Leu Glu Val Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val           
                485                 490                 495               

agc ttg cgg aat cgg cag ggc cag cat ttc tgc ggg ggg tct cta gtg       1536
Ser Leu Arg Asn Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val           
            500                 505                 510                   

aag gag cag tgg ata ctg act gcc cgg cag tgc ttc tcc tcc tgc cat       1584
Lys Glu Gln Trp Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser Cys His           
        515                 520                 525                       

atg cct ctc acg ggc tat gag gta tgg ttg ggc acc ctg ttc cag aac       1632
Met Pro Leu Thr Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe Gln Asn           
    530                 535                 540                           

cca cag cat gga gag cca agc cta cag cgg gtc cca gta gcc aag atg       1680
Pro Gln His Gly Glu Pro Ser Leu Gln Arg Val Pro Val Ala Lys Met           
545                 550                 555                 560           

gtg tgt ggg ccc tca ggc tcc cag ctt gtc ctg ctc aag ctg gag aga       1728
Val Cys Gly Pro Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg           
                565                 570                 575               

tct gtg acc ctg aac cag cgt gtg gcc ctg atc tgc ctg ccc cct gaa       1776
Ser Val Thr Leu Asn Gln Arg Val Ala Leu Ile Cys Leu Pro Pro Glu           
            580                 585                 590                   

tgg tat gtg gtg cct cca ggg acc aag tgt gag att gca ggc tgg ggt       1824
Trp Tyr Val Val Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly           
        595                 600                 605                       

gag acc aaa ggt acg ggt aat gac aca gtc cta aat gtg gcc ttg ctg       1872
Glu Thr Lys Gly Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu           
    610                 615                 620                           

aat gtc atc tcc aac cag gag tgt aac atc aag cac cga gga cgt gtg       1920
Asn Val Ile Ser Asn Gln Glu Cys Asn Ile Lys His Arg Gly Arg Val           
625                 630                 635                 640           

cgg gag agt gag atg tgc act gag gga ctg ttg gcc cct gtg ggg gcc       1968
Arg Glu Ser Glu Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly Ala           
                645                 650                 655               

tgt gag ggt gac tac ggg ggc cca ctt gcc tgc ttt acc cac aac gcc       2016
Cys Glu Gly Asp Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn Ala           
            660                 665                 670                   

tgg gtc ctg gaa gga att ata atc ccc aac cga gta tgc gca agg tcc       2064
Trp Val Leu Glu Gly Ile Ile Ile Pro Asn Arg Val Cys Ala Arg Ser           
        675                 680                 685                       

cgc tgg cca gct gtc ttc acg cgt gtc tct gtg ttt gtg gac tgg att       2112
Arg Trp Pro Ala Val Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile           
    690                 695                 700                           

cac aag gtc atg aga ctg ggt cat cat cat cat cat cat tag               2154
His Lys Val Met Arg Leu Gly His His His His His His                       
705                 710                 715                               


<210>  6
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Gly Trp Leu Pro Leu Leu Leu Leu Leu Thr Gln Cys Leu Gly Val 
1               5                   10                  15      


Pro Gly Gln Arg Ser Pro Leu Asn Asp Phe Gln Val Leu Arg Gly Thr 
            20                  25                  30          


Glu Leu Gln His Leu Leu His Ala Val Val Pro Gly Pro Trp Gln Glu 
        35                  40                  45              


Asp Val Ala Asp Ala Glu Glu Cys Ala Gly Arg Cys Gly Pro Leu Met 
    50                  55                  60                  


Asp Cys Arg Ala Phe His Tyr Asn Val Ser Ser His Gly Cys Gln Leu 
65                  70                  75                  80  


Leu Pro Trp Thr Gln His Ser Pro His Thr Arg Leu Arg Arg Ser Gly 
                85                  90                  95      


Arg Cys Asp Leu Phe Gln Lys Lys Asp Tyr Val Arg Thr Cys Ile Met 
            100                 105                 110         


Asn Asn Gly Val Gly Tyr Arg Gly Thr Met Ala Thr Thr Val Gly Gly 
        115                 120                 125             


Leu Pro Cys Gln Ala Trp Ser His Lys Phe Pro Asn Asp His Lys Tyr 
    130                 135                 140                 


Thr Pro Thr Leu Arg Asn Gly Leu Glu Glu Asn Phe Cys Arg Asn Pro 
145                 150                 155                 160 


Asp Gly Asp Pro Gly Gly Pro Trp Cys Tyr Thr Thr Asp Pro Ala Val 
                165                 170                 175     


Arg Phe Gln Ser Cys Gly Ile Lys Ser Cys Arg Glu Ala Ala Cys Val 
            180                 185                 190         


Trp Cys Asn Gly Glu Glu Tyr Arg Gly Ala Val Asp Arg Thr Glu Ser 
        195                 200                 205             


Gly Arg Glu Cys Gln Arg Trp Asp Leu Gln His Pro His Gln His Pro 
    210                 215                 220                 


Phe Glu Pro Gly Lys Phe Leu Asp Gln Gly Leu Asp Asp Asn Tyr Cys 
225                 230                 235                 240 


Arg Asn Pro Asp Gly Ser Glu Arg Pro Trp Cys Tyr Thr Thr Asp Pro 
                245                 250                 255     


Gln Ile Glu Arg Glu Phe Cys Asp Leu Pro Arg Cys Gly Ser Glu Ala 
            260                 265                 270         


Gln Pro Arg Gln Glu Ala Thr Thr Val Ser Cys Phe Arg Gly Lys Gly 
        275                 280                 285             


Glu Gly Tyr Arg Gly Thr Ala Asn Thr Thr Thr Ala Gly Val Pro Cys 
    290                 295                 300                 


Gln Arg Trp Asp Ala Gln Ile Pro His Gln His Arg Phe Thr Pro Glu 
305                 310                 315                 320 


Lys Tyr Ala Cys Lys Asp Leu Arg Glu Asn Phe Cys Arg Asn Pro Asp 
                325                 330                 335     


Gly Ser Glu Ala Pro Trp Cys Phe Thr Leu Arg Pro Gly Met Arg Ala 
            340                 345                 350         


Ala Phe Cys Tyr Gln Ile Arg Arg Cys Thr Asp Asp Val Arg Pro Gln 
        355                 360                 365             


Asp Cys Tyr His Gly Ala Gly Glu Gln Tyr Arg Gly Thr Val Ser Lys 
    370                 375                 380                 


Thr Arg Lys Gly Val Gln Cys Gln Arg Trp Ser Ala Glu Thr Pro His 
385                 390                 395                 400 


Lys Pro Gln Phe Thr Phe Thr Ser Glu Pro His Ala Gln Leu Glu Glu 
                405                 410                 415     


Asn Phe Cys Arg Asn Pro Asp Gly Asp Ser His Gly Pro Trp Cys Tyr 
            420                 425                 430         


Thr Met Asp Pro Arg Thr Pro Phe Asp Tyr Cys Ala Leu Arg Arg Cys 
        435                 440                 445             


Ala Asp Asp Gln Pro Pro Ser Ile Leu Asp Pro Pro Asp Gln Val Gln 
    450                 455                 460                 


Phe Glu Lys Cys Gly Lys Arg Val Asp Arg Leu Asp Gln Arg Arg Ser 
465                 470                 475                 480 


Lys Leu Glu Val Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val 
                485                 490                 495     


Ser Leu Arg Asn Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val 
            500                 505                 510         


Lys Glu Gln Trp Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser Cys His 
        515                 520                 525             


Met Pro Leu Thr Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe Gln Asn 
    530                 535                 540                 


Pro Gln His Gly Glu Pro Ser Leu Gln Arg Val Pro Val Ala Lys Met 
545                 550                 555                 560 


Val Cys Gly Pro Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg 
                565                 570                 575     


Ser Val Thr Leu Asn Gln Arg Val Ala Leu Ile Cys Leu Pro Pro Glu 
            580                 585                 590         


Trp Tyr Val Val Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly 
        595                 600                 605             


Glu Thr Lys Gly Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu 
    610                 615                 620                 


Asn Val Ile Ser Asn Gln Glu Cys Asn Ile Lys His Arg Gly Arg Val 
625                 630                 635                 640 


Arg Glu Ser Glu Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly Ala 
                645                 650                 655     


Cys Glu Gly Asp Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn Ala 
            660                 665                 670         


Trp Val Leu Glu Gly Ile Ile Ile Pro Asn Arg Val Cys Ala Arg Ser 
        675                 680                 685             


Arg Trp Pro Ala Val Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile 
    690                 695                 700                 


His Lys Val Met Arg Leu Gly His His His His His His 
705                 710                 715         


<210>  7
<211>  804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(804)

<400>  7
atg tgg gtg acc aaa ctc ctg cca gcc ctg ctg ctg cag cat gtc ctc         48
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu           
1               5                   10                  15                

ctg cat ctc ctc ctg ctc ccc atc gcc atc ccc tat gca gag gga gtg         96
Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val           
            20                  25                  30                    

gtt ggg ggc cat ccg ggc aac tca ccc tgg aca gtc agc ttg cgg aat        144
Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn           
        35                  40                  45                        

cgg cag ggc cag cat ttc tgc ggg ggg tct cta gtg aag gag cag tgg        192
Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp           
    50                  55                  60                            

ata ctg act gcc cgg cag tgc ttc tcc tcc tgc cat atg cct ctc acg        240
Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser Cys His Met Pro Leu Thr           
65                  70                  75                  80            

ggc tat gag gta tgg ttg ggc acc ctg ttc cag aac cca cag cat gga        288
Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe Gln Asn Pro Gln His Gly           
                85                  90                  95                

gag cca agc cta cag cgg gtc cca gta gcc aag atg gtg tgt ggg ccc        336
Glu Pro Ser Leu Gln Arg Val Pro Val Ala Lys Met Val Cys Gly Pro           
            100                 105                 110                   

tca ggc tcc cag ctt gtc ctg ctc aag ctg gag aga tct gtg acc ctg        384
Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Ser Val Thr Leu           
        115                 120                 125                       

aac cag cgt gtg gcc ctg atc tcc ctg ccc cct gaa tgg tat gtg gtg        432
Asn Gln Arg Val Ala Leu Ile Ser Leu Pro Pro Glu Trp Tyr Val Val           
    130                 135                 140                           

cct cca ggg acc aag tgt gag att gca ggc tgg ggt gag acc aaa ggt        480
Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Thr Lys Gly           
145                 150                 155                 160           

acg ggt aat gac aca gtc cta aat gtg gcc ttg ctg aat gtc atc tcc        528
Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu Asn Val Ile Ser           
                165                 170                 175               

aac cag gag tgt aac atc aag cac cga gga cgt gtg cgg gag agt gag        576
Asn Gln Glu Cys Asn Ile Lys His Arg Gly Arg Val Arg Glu Ser Glu           
            180                 185                 190                   

atg tgc act gag gga ctg ttg gcc cct gtg ggg gcc tgt gag ggt gac        624
Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly Ala Cys Glu Gly Asp           
        195                 200                 205                       

tac ggg ggc cca ctt gcc tgc ttt acc cac aac tgc tgg gtc ctg gaa        672
Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn Cys Trp Val Leu Glu           
    210                 215                 220                           

gga att ata atc ccc aac cga gta tgc gca agg tcc cgc tgg cca gct        720
Gly Ile Ile Ile Pro Asn Arg Val Cys Ala Arg Ser Arg Trp Pro Ala           
225                 230                 235                 240           

gtc ttc acg cgt gtc tct gtg ttt gtg gac tgg att cac aag gtc atg        768
Val Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile His Lys Val Met           
                245                 250                 255               

aga ctg ggt cat cat cat cat cat cat cat cat tag                        804
Arg Leu Gly His His His His His His His His                               
            260                 265                                       


<210>  8
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val 
            20                  25                  30          


Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn 
        35                  40                  45              


Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp 
    50                  55                  60                  


Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser Cys His Met Pro Leu Thr 
65                  70                  75                  80  


Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe Gln Asn Pro Gln His Gly 
                85                  90                  95      


Glu Pro Ser Leu Gln Arg Val Pro Val Ala Lys Met Val Cys Gly Pro 
            100                 105                 110         


Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Ser Val Thr Leu 
        115                 120                 125             


Asn Gln Arg Val Ala Leu Ile Ser Leu Pro Pro Glu Trp Tyr Val Val 
    130                 135                 140                 


Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Thr Lys Gly 
145                 150                 155                 160 


Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu Asn Val Ile Ser 
                165                 170                 175     


Asn Gln Glu Cys Asn Ile Lys His Arg Gly Arg Val Arg Glu Ser Glu 
            180                 185                 190         


Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly Ala Cys Glu Gly Asp 
        195                 200                 205             


Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn Cys Trp Val Leu Glu 
    210                 215                 220                 


Gly Ile Ile Ile Pro Asn Arg Val Cys Ala Arg Ser Arg Trp Pro Ala 
225                 230                 235                 240 


Val Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile His Lys Val Met 
                245                 250                 255     


Arg Leu Gly His His His His His His His His 
            260                 265         


<210>  9
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  9

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val 
            20                  25                  30          


Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn 
        35                  40                  45              


Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp 
    50                  55                  60                  


Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser Cys His Met Pro Leu Thr 
65                  70                  75                  80  


Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe Gln Asn Pro Gln His Gly 
                85                  90                  95      


Glu Pro Ser Leu Gln Arg Val Pro Val Ala Lys Met Val Cys Gly Pro 
            100                 105                 110         


Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Ser Val Thr Leu 
        115                 120                 125             


Asn Gln Arg Val Ala Leu Ile Ser Leu Pro Pro Glu Trp Tyr Val Val 
    130                 135                 140                 


Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Thr Lys Gly 
145                 150                 155                 160 


Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu Asn Val Ile Ser 
                165                 170                 175     


Asn Gln Glu Cys Asn Ile Lys His Arg Gly Arg Val Arg Glu Ser Glu 
            180                 185                 190         


Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly Ala Cys Glu Gly Asp 
        195                 200                 205             


Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn Ala Trp Val Leu Glu 
    210                 215                 220                 


Gly Ile Ile Ile Pro Asn Arg Val Cys Ala Arg Ser Arg Trp Pro Ala 
225                 230                 235                 240 


Val Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile His Lys Val Met 
                245                 250                 255     


Arg Leu Gly His His His His His His His His 
            260                 265         


<210>  10
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  10

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val 
            20                  25                  30          


Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn 
        35                  40                  45              


Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp 
    50                  55                  60                  


Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser Cys His Met Pro Leu Thr 
65                  70                  75                  80  


Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe Gln Asn Pro Gln His Gly 
                85                  90                  95      


Glu Pro Ser Leu Gln Arg Val Pro Val Ala Lys Met Val Cys Gly Pro 
            100                 105                 110         


Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Ser Val Thr Leu 
        115                 120                 125             


Asn Gln Arg Val Ala Leu Ile Ser Leu Pro Pro Glu Trp Tyr Val Val 
    130                 135                 140                 


Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Thr Lys Gly 
145                 150                 155                 160 


Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu Asn Val Ile Ser 
                165                 170                 175     


Asn Gln Glu Cys Asn Ile Lys His Arg Gly Arg Val Arg Glu Ser Glu 
            180                 185                 190         


Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly Ala Cys Glu Gly Asp 
        195                 200                 205             


Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn Cys Trp Val Leu Glu 
    210                 215                 220                 


Gly Ile Ile Ile Pro Asn Arg Val Cys Ala Arg Ser Cys Trp Pro Ala 
225                 230                 235                 240 


Val Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile His Lys Val Met 
                245                 250                 255     


Arg Leu Gly His His His His His His His His 
            260                 265         


<210>  11
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  11

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val 
            20                  25                  30          


Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn 
        35                  40                  45              


Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp 
    50                  55                  60                  


Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser Cys His Met Pro Leu Thr 
65                  70                  75                  80  


Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe Gln Asn Pro Gln His Gly 
                85                  90                  95      


Glu Pro Ser Leu Gln Arg Val Pro Val Ala Lys Met Val Cys Gly Pro 
            100                 105                 110         


Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Ser Val Thr Leu 
        115                 120                 125             


Asn Gln Arg Val Ala Leu Ile Ser Leu Pro Pro Glu Trp Tyr Val Val 
    130                 135                 140                 


Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Thr Lys Gly 
145                 150                 155                 160 


Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu Asn Val Ile Ser 
                165                 170                 175     


Asn Gln Glu Cys Asn Ile Lys His Arg Gly Arg Val Arg Glu Ser Glu 
            180                 185                 190         


Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly Ala Cys Glu Gly Asp 
        195                 200                 205             


Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn Ala Trp Val Leu Glu 
    210                 215                 220                 


Gly Ile Ile Ile Pro Asn Arg Val Cys Ala Arg Ser Cys Trp Pro Ala 
225                 230                 235                 240 


Val Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile His Lys Val Met 
                245                 250                 255     


Arg Leu Gly His His His His His His His His 
            260                 265         


<210>  12
<211>  711
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gly Trp Leu Pro Leu Leu Leu Leu Leu Thr Gln Cys Leu Gly Val 
1               5                   10                  15      


Pro Gly Gln Arg Ser Pro Leu Asn Asp Phe Gln Val Leu Arg Gly Thr 
            20                  25                  30          


Glu Leu Gln His Leu Leu His Ala Val Val Pro Gly Pro Trp Gln Glu 
        35                  40                  45              


Asp Val Ala Asp Ala Glu Glu Cys Ala Gly Arg Cys Gly Pro Leu Met 
    50                  55                  60                  


Asp Cys Arg Ala Phe His Tyr Asn Val Ser Ser His Gly Cys Gln Leu 
65                  70                  75                  80  


Leu Pro Trp Thr Gln His Ser Pro His Thr Arg Leu Arg Arg Ser Gly 
                85                  90                  95      


Arg Cys Asp Leu Phe Gln Lys Lys Asp Tyr Val Arg Thr Cys Ile Met 
            100                 105                 110         


Asn Asn Gly Val Gly Tyr Arg Gly Thr Met Ala Thr Thr Val Gly Gly 
        115                 120                 125             


Leu Pro Cys Gln Ala Trp Ser His Lys Phe Pro Asn Asp His Lys Tyr 
    130                 135                 140                 


Thr Pro Thr Leu Arg Asn Gly Leu Glu Glu Asn Phe Cys Arg Asn Pro 
145                 150                 155                 160 


Asp Gly Asp Pro Gly Gly Pro Trp Cys Tyr Thr Thr Asp Pro Ala Val 
                165                 170                 175     


Arg Phe Gln Ser Cys Gly Ile Lys Ser Cys Arg Glu Ala Ala Cys Val 
            180                 185                 190         


Trp Cys Asn Gly Glu Glu Tyr Arg Gly Ala Val Asp Arg Thr Glu Ser 
        195                 200                 205             


Gly Arg Glu Cys Gln Arg Trp Asp Leu Gln His Pro His Gln His Pro 
    210                 215                 220                 


Phe Glu Pro Gly Lys Phe Leu Asp Gln Gly Leu Asp Asp Asn Tyr Cys 
225                 230                 235                 240 


Arg Asn Pro Asp Gly Ser Glu Arg Pro Trp Cys Tyr Thr Thr Asp Pro 
                245                 250                 255     


Gln Ile Glu Arg Glu Phe Cys Asp Leu Pro Arg Cys Gly Ser Glu Ala 
            260                 265                 270         


Gln Pro Arg Gln Glu Ala Thr Thr Val Ser Cys Phe Arg Gly Lys Gly 
        275                 280                 285             


Glu Gly Tyr Arg Gly Thr Ala Asn Thr Thr Thr Ala Gly Val Pro Cys 
    290                 295                 300                 


Gln Arg Trp Asp Ala Gln Ile Pro His Gln His Arg Phe Thr Pro Glu 
305                 310                 315                 320 


Lys Tyr Ala Cys Lys Asp Leu Arg Glu Asn Phe Cys Arg Asn Pro Asp 
                325                 330                 335     


Gly Ser Glu Ala Pro Trp Cys Phe Thr Leu Arg Pro Gly Met Arg Ala 
            340                 345                 350         


Ala Phe Cys Tyr Gln Ile Arg Arg Cys Thr Asp Asp Val Arg Pro Gln 
        355                 360                 365             


Asp Cys Tyr His Gly Ala Gly Glu Gln Tyr Arg Gly Thr Val Ser Lys 
    370                 375                 380                 


Thr Arg Lys Gly Val Gln Cys Gln Arg Trp Ser Ala Glu Thr Pro His 
385                 390                 395                 400 


Lys Pro Gln Phe Thr Phe Thr Ser Glu Pro His Ala Gln Leu Glu Glu 
                405                 410                 415     


Asn Phe Cys Arg Asn Pro Asp Gly Asp Ser His Gly Pro Trp Cys Tyr 
            420                 425                 430         


Thr Met Asp Pro Arg Thr Pro Phe Asp Tyr Cys Ala Leu Arg Arg Cys 
        435                 440                 445             


Ala Asp Asp Gln Pro Pro Ser Ile Leu Asp Pro Pro Asp Gln Val Gln 
    450                 455                 460                 


Phe Glu Lys Cys Gly Lys Arg Val Asp Arg Leu Asp Gln Arg Arg Ser 
465                 470                 475                 480 


Lys Leu Arg Val Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val 
                485                 490                 495     


Ser Leu Arg Asn Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val 
            500                 505                 510         


Lys Glu Gln Trp Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser Cys His 
        515                 520                 525             


Met Pro Leu Thr Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe Gln Asn 
    530                 535                 540                 


Pro Gln His Gly Glu Pro Ser Leu Gln Arg Val Pro Val Ala Lys Met 
545                 550                 555                 560 


Val Cys Gly Pro Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg 
                565                 570                 575     


Ser Val Thr Leu Asn Gln Arg Val Ala Leu Ile Cys Leu Pro Pro Glu 
            580                 585                 590         


Trp Tyr Val Val Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly 
        595                 600                 605             


Glu Thr Lys Gly Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu 
    610                 615                 620                 


Asn Val Ile Ser Asn Gln Glu Cys Asn Ile Lys His Arg Gly Arg Val 
625                 630                 635                 640 


Arg Glu Ser Glu Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly Ala 
                645                 650                 655     


Cys Glu Gly Asp Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn Cys 
            660                 665                 670         


Trp Val Leu Glu Gly Ile Ile Ile Pro Asn Arg Val Cys Ala Arg Ser 
        675                 680                 685             


Arg Trp Pro Ala Val Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile 
    690                 695                 700                 


His Lys Val Met Arg Leu Gly 
705                 710     


<210>  13
<211>  2151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(2151)

<400>  13
atg ggg tgg ctc cca ctt ctg ctg ctt ctg gta cag tgt tca agg gct         48
Met Gly Trp Leu Pro Leu Leu Leu Leu Leu Val Gln Cys Ser Arg Ala           
1               5                   10                  15                

ctt ggg cag cgc tca cca ctg aat gac ttc cag ctg ttc cgg ggc aca         96
Leu Gly Gln Arg Ser Pro Leu Asn Asp Phe Gln Leu Phe Arg Gly Thr           
            20                  25                  30                    

gag tta agg aac ctg tta cac aca gcg gtg ccg ggg cca tgg cag gag        144
Glu Leu Arg Asn Leu Leu His Thr Ala Val Pro Gly Pro Trp Gln Glu           
        35                  40                  45                        

gat gtg gca gat gct gag gag tgt gct agg cgc tgt ggg ccc ctt ctg        192
Asp Val Ala Asp Ala Glu Glu Cys Ala Arg Arg Cys Gly Pro Leu Leu           
    50                  55                  60                            

gac tgt cgg gcc ttc cac tac aac atg agc agc cat ggt tgc cag ctg        240
Asp Cys Arg Ala Phe His Tyr Asn Met Ser Ser His Gly Cys Gln Leu           
65                  70                  75                  80            

ctg ccg tgg acc cag cac tcg ctg cac aca cag cta tac cac tcg agt        288
Leu Pro Trp Thr Gln His Ser Leu His Thr Gln Leu Tyr His Ser Ser           
                85                  90                  95                

ctg tgc cat ctc ttc cag aag aaa gat tat gtg cgg acc tgc att atg        336
Leu Cys His Leu Phe Gln Lys Lys Asp Tyr Val Arg Thr Cys Ile Met           
            100                 105                 110                   

gac aat ggg gtc agc tac cgg ggc act gtg gcc agg aca gct ggt ggc        384
Asp Asn Gly Val Ser Tyr Arg Gly Thr Val Ala Arg Thr Ala Gly Gly           
        115                 120                 125                       

ctg ccc tgc caa gcc tgg agt cgc agg ttc ccc aat gac cac aag tat        432
Leu Pro Cys Gln Ala Trp Ser Arg Arg Phe Pro Asn Asp His Lys Tyr           
    130                 135                 140                           

acg ccc acg cca aag aat ggc ctg gaa gag aac ttc tgt agg aac cct        480
Thr Pro Thr Pro Lys Asn Gly Leu Glu Glu Asn Phe Cys Arg Asn Pro           
145                 150                 155                 160           

gat ggg gat ccc aga ggt ccc tgg tgc tac aca aca aac cgc agt gtg        528
Asp Gly Asp Pro Arg Gly Pro Trp Cys Tyr Thr Thr Asn Arg Ser Val           
                165                 170                 175               

cgt ttc cag agc tgt ggc atc aaa acc tgc agg gag gct gtt tgt gtt        576
Arg Phe Gln Ser Cys Gly Ile Lys Thr Cys Arg Glu Ala Val Cys Val           
            180                 185                 190                   

ctg tgc aac ggt gag gat tac cgt ggc gag gta gac gtt aca gag tca        624
Leu Cys Asn Gly Glu Asp Tyr Arg Gly Glu Val Asp Val Thr Glu Ser           
        195                 200                 205                       

ggg cgg gag tgt caa cgc tgg gac ctg cag cac ccc cac tcg cac cct        672
Gly Arg Glu Cys Gln Arg Trp Asp Leu Gln His Pro His Ser His Pro           
    210                 215                 220                           

ttc cag cct gaa aag ttc cta gac aaa gat ctg aaa gac aac tat tgt        720
Phe Gln Pro Glu Lys Phe Leu Asp Lys Asp Leu Lys Asp Asn Tyr Cys           
225                 230                 235                 240           

cgt aat ccg gac gga tct gag cgg ccc tgg tgc tac acc aca gac ccg        768
Arg Asn Pro Asp Gly Ser Glu Arg Pro Trp Cys Tyr Thr Thr Asp Pro           
                245                 250                 255               

aat gtt gag cga gaa ttc tgc gac ctg ccc agt tgc ggg cct aac ctg        816
Asn Val Glu Arg Glu Phe Cys Asp Leu Pro Ser Cys Gly Pro Asn Leu           
            260                 265                 270                   

cct ccg acc gtc aaa gga tcc aag tca cag cgg cgc aac aag ggc aag        864
Pro Pro Thr Val Lys Gly Ser Lys Ser Gln Arg Arg Asn Lys Gly Lys           
        275                 280                 285                       

gct ctt aac tgc ttc cgc gga aaa ggt gaa gac tat cga ggc aca acc        912
Ala Leu Asn Cys Phe Arg Gly Lys Gly Glu Asp Tyr Arg Gly Thr Thr           
    290                 295                 300                           

aat acc acc tct gcg ggc gtg ccc tgc cag cgg tgg gat gcg cag agt        960
Asn Thr Thr Ser Ala Gly Val Pro Cys Gln Arg Trp Asp Ala Gln Ser           
305                 310                 315                 320           

cca cac cag cac cgc ttt gtg cca gag aaa tat gct tgc aag gac ctt       1008
Pro His Gln His Arg Phe Val Pro Glu Lys Tyr Ala Cys Lys Asp Leu           
                325                 330                 335               

cgt gag aat ttc tgc cgg aat cct gat ggc tcc gag gcg cct tgg tgc       1056
Arg Glu Asn Phe Cys Arg Asn Pro Asp Gly Ser Glu Ala Pro Trp Cys           
            340                 345                 350                   

ttc aca tct cga cct ggt ttg cgc atg gcc ttc tgc cac cag atc cca       1104
Phe Thr Ser Arg Pro Gly Leu Arg Met Ala Phe Cys His Gln Ile Pro           
        355                 360                 365                       

cgc tgc act gaa gaa ctg gtg cca gag gga tgc tac cac ggc tca ggt       1152
Arg Cys Thr Glu Glu Leu Val Pro Glu Gly Cys Tyr His Gly Ser Gly           
    370                 375                 380                           

gaa cag tat cgt ggc tca gtc agc aag acg cgc aag ggc gtt cag tgc       1200
Glu Gln Tyr Arg Gly Ser Val Ser Lys Thr Arg Lys Gly Val Gln Cys           
385                 390                 395                 400           

cag cac tgg tcc tct gag aca ccg cac aag cca caa ttt aca ccc acc       1248
Gln His Trp Ser Ser Glu Thr Pro His Lys Pro Gln Phe Thr Pro Thr           
                405                 410                 415               

tcg gca ccg cag gcg gga ctg gag gcc aac ttc tgc agg aat cct gat       1296
Ser Ala Pro Gln Ala Gly Leu Glu Ala Asn Phe Cys Arg Asn Pro Asp           
            420                 425                 430                   

ggg gat agc cat ggg ccc tgg tgc tat acc ttg gac ccg gat atc ctg       1344
Gly Asp Ser His Gly Pro Trp Cys Tyr Thr Leu Asp Pro Asp Ile Leu           
        435                 440                 445                       

ttt gac tac tgt gcc cta cag cgc tgt gat gat gac cag cca cca tcc       1392
Phe Asp Tyr Cys Ala Leu Gln Arg Cys Asp Asp Asp Gln Pro Pro Ser           
    450                 455                 460                           

att ctg gac ccc cca gac cag gtg gtg ttt gaa aag tgt ggc aag aga       1440
Ile Leu Asp Pro Pro Asp Gln Val Val Phe Glu Lys Cys Gly Lys Arg           
465                 470                 475                 480           

gtt gac aag agt aat aaa ctt cgt gtg gtg gga ggc cat cct ggg aac       1488
Val Asp Lys Ser Asn Lys Leu Arg Val Val Gly Gly His Pro Gly Asn           
                485                 490                 495               

tcc cca tgg acg gtc agc ttg cgg aat cga cag ggc cag cat ttc tgt       1536
Ser Pro Trp Thr Val Ser Leu Arg Asn Arg Gln Gly Gln His Phe Cys           
            500                 505                 510                   

ggg ggc tcc cta gtg aag gag cag tgg gta ctg act gcc cgg caa tgc       1584
Gly Gly Ser Leu Val Lys Glu Gln Trp Val Leu Thr Ala Arg Gln Cys           
        515                 520                 525                       

atc tgg tca tgc cac gaa cct ctc aca gga tac gag gta tgg ttg ggt       1632
Ile Trp Ser Cys His Glu Pro Leu Thr Gly Tyr Glu Val Trp Leu Gly           
    530                 535                 540                           

aca att aac cag aac cca cag cct gga gag gca aac ctg cag agg gtc       1680
Thr Ile Asn Gln Asn Pro Gln Pro Gly Glu Ala Asn Leu Gln Arg Val           
545                 550                 555                 560           

cca gtg gcc aag gca gtg tgc ggc cct gca ggc tcc cag ctt gtt ctg       1728
Pro Val Ala Lys Ala Val Cys Gly Pro Ala Gly Ser Gln Leu Val Leu           
                565                 570                 575               

ctc aag ctg gag aga cct gtg atc ctg aac cat cac gtg gcc ctg att       1776
Leu Lys Leu Glu Arg Pro Val Ile Leu Asn His His Val Ala Leu Ile           
            580                 585                 590                   

tgc ctg cct cct gaa cag tat gtg gta cct cca ggg acc aag tgt gag       1824
Cys Leu Pro Pro Glu Gln Tyr Val Val Pro Pro Gly Thr Lys Cys Glu           
        595                 600                 605                       

atc gca ggc tgg ggt gaa tcc atc ggt aca agc aat aac aca gtc ctt       1872
Ile Ala Gly Trp Gly Glu Ser Ile Gly Thr Ser Asn Asn Thr Val Leu           
    610                 615                 620                           

cat gtg gcc tcg atg aat gtc atc tcc aac cag gaa tgt aac acg aag       1920
His Val Ala Ser Met Asn Val Ile Ser Asn Gln Glu Cys Asn Thr Lys           
625                 630                 635                 640           

tac cga gga cac ata caa gag agt gag ata tgc acc cag gga ctg gtg       1968
Tyr Arg Gly His Ile Gln Glu Ser Glu Ile Cys Thr Gln Gly Leu Val           
                645                 650                 655               

gtc cct gtg ggg gct tgt gag ggt gac tac ggg ggc cca ctt gcc tgc       2016
Val Pro Val Gly Ala Cys Glu Gly Asp Tyr Gly Gly Pro Leu Ala Cys           
            660                 665                 670                   

tat acc cat gac tgc tgg gtc cta cag gga ctt atc atc ccg aac aga       2064
Tyr Thr His Asp Cys Trp Val Leu Gln Gly Leu Ile Ile Pro Asn Arg           
        675                 680                 685                       

gtg tgt gca cgg ccc cgc tgg cca gct atc ttc aca cgg gtg tct gtg       2112
Val Cys Ala Arg Pro Arg Trp Pro Ala Ile Phe Thr Arg Val Ser Val           
    690                 695                 700                           

ttc gtg gac tgg att aac aag gtc atg cag ctg gag tag                   2151
Phe Val Asp Trp Ile Asn Lys Val Met Gln Leu Glu                           
705                 710                 715                               


<210>  14
<211>  716
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Met Gly Trp Leu Pro Leu Leu Leu Leu Leu Val Gln Cys Ser Arg Ala 
1               5                   10                  15      


Leu Gly Gln Arg Ser Pro Leu Asn Asp Phe Gln Leu Phe Arg Gly Thr 
            20                  25                  30          


Glu Leu Arg Asn Leu Leu His Thr Ala Val Pro Gly Pro Trp Gln Glu 
        35                  40                  45              


Asp Val Ala Asp Ala Glu Glu Cys Ala Arg Arg Cys Gly Pro Leu Leu 
    50                  55                  60                  


Asp Cys Arg Ala Phe His Tyr Asn Met Ser Ser His Gly Cys Gln Leu 
65                  70                  75                  80  


Leu Pro Trp Thr Gln His Ser Leu His Thr Gln Leu Tyr His Ser Ser 
                85                  90                  95      


Leu Cys His Leu Phe Gln Lys Lys Asp Tyr Val Arg Thr Cys Ile Met 
            100                 105                 110         


Asp Asn Gly Val Ser Tyr Arg Gly Thr Val Ala Arg Thr Ala Gly Gly 
        115                 120                 125             


Leu Pro Cys Gln Ala Trp Ser Arg Arg Phe Pro Asn Asp His Lys Tyr 
    130                 135                 140                 


Thr Pro Thr Pro Lys Asn Gly Leu Glu Glu Asn Phe Cys Arg Asn Pro 
145                 150                 155                 160 


Asp Gly Asp Pro Arg Gly Pro Trp Cys Tyr Thr Thr Asn Arg Ser Val 
                165                 170                 175     


Arg Phe Gln Ser Cys Gly Ile Lys Thr Cys Arg Glu Ala Val Cys Val 
            180                 185                 190         


Leu Cys Asn Gly Glu Asp Tyr Arg Gly Glu Val Asp Val Thr Glu Ser 
        195                 200                 205             


Gly Arg Glu Cys Gln Arg Trp Asp Leu Gln His Pro His Ser His Pro 
    210                 215                 220                 


Phe Gln Pro Glu Lys Phe Leu Asp Lys Asp Leu Lys Asp Asn Tyr Cys 
225                 230                 235                 240 


Arg Asn Pro Asp Gly Ser Glu Arg Pro Trp Cys Tyr Thr Thr Asp Pro 
                245                 250                 255     


Asn Val Glu Arg Glu Phe Cys Asp Leu Pro Ser Cys Gly Pro Asn Leu 
            260                 265                 270         


Pro Pro Thr Val Lys Gly Ser Lys Ser Gln Arg Arg Asn Lys Gly Lys 
        275                 280                 285             


Ala Leu Asn Cys Phe Arg Gly Lys Gly Glu Asp Tyr Arg Gly Thr Thr 
    290                 295                 300                 


Asn Thr Thr Ser Ala Gly Val Pro Cys Gln Arg Trp Asp Ala Gln Ser 
305                 310                 315                 320 


Pro His Gln His Arg Phe Val Pro Glu Lys Tyr Ala Cys Lys Asp Leu 
                325                 330                 335     


Arg Glu Asn Phe Cys Arg Asn Pro Asp Gly Ser Glu Ala Pro Trp Cys 
            340                 345                 350         


Phe Thr Ser Arg Pro Gly Leu Arg Met Ala Phe Cys His Gln Ile Pro 
        355                 360                 365             


Arg Cys Thr Glu Glu Leu Val Pro Glu Gly Cys Tyr His Gly Ser Gly 
    370                 375                 380                 


Glu Gln Tyr Arg Gly Ser Val Ser Lys Thr Arg Lys Gly Val Gln Cys 
385                 390                 395                 400 


Gln His Trp Ser Ser Glu Thr Pro His Lys Pro Gln Phe Thr Pro Thr 
                405                 410                 415     


Ser Ala Pro Gln Ala Gly Leu Glu Ala Asn Phe Cys Arg Asn Pro Asp 
            420                 425                 430         


Gly Asp Ser His Gly Pro Trp Cys Tyr Thr Leu Asp Pro Asp Ile Leu 
        435                 440                 445             


Phe Asp Tyr Cys Ala Leu Gln Arg Cys Asp Asp Asp Gln Pro Pro Ser 
    450                 455                 460                 


Ile Leu Asp Pro Pro Asp Gln Val Val Phe Glu Lys Cys Gly Lys Arg 
465                 470                 475                 480 


Val Asp Lys Ser Asn Lys Leu Arg Val Val Gly Gly His Pro Gly Asn 
                485                 490                 495     


Ser Pro Trp Thr Val Ser Leu Arg Asn Arg Gln Gly Gln His Phe Cys 
            500                 505                 510         


Gly Gly Ser Leu Val Lys Glu Gln Trp Val Leu Thr Ala Arg Gln Cys 
        515                 520                 525             


Ile Trp Ser Cys His Glu Pro Leu Thr Gly Tyr Glu Val Trp Leu Gly 
    530                 535                 540                 


Thr Ile Asn Gln Asn Pro Gln Pro Gly Glu Ala Asn Leu Gln Arg Val 
545                 550                 555                 560 


Pro Val Ala Lys Ala Val Cys Gly Pro Ala Gly Ser Gln Leu Val Leu 
                565                 570                 575     


Leu Lys Leu Glu Arg Pro Val Ile Leu Asn His His Val Ala Leu Ile 
            580                 585                 590         


Cys Leu Pro Pro Glu Gln Tyr Val Val Pro Pro Gly Thr Lys Cys Glu 
        595                 600                 605             


Ile Ala Gly Trp Gly Glu Ser Ile Gly Thr Ser Asn Asn Thr Val Leu 
    610                 615                 620                 


His Val Ala Ser Met Asn Val Ile Ser Asn Gln Glu Cys Asn Thr Lys 
625                 630                 635                 640 


Tyr Arg Gly His Ile Gln Glu Ser Glu Ile Cys Thr Gln Gly Leu Val 
                645                 650                 655     


Val Pro Val Gly Ala Cys Glu Gly Asp Tyr Gly Gly Pro Leu Ala Cys 
            660                 665                 670         


Tyr Thr His Asp Cys Trp Val Leu Gln Gly Leu Ile Ile Pro Asn Arg 
        675                 680                 685             


Val Cys Ala Arg Pro Arg Trp Pro Ala Ile Phe Thr Arg Val Ser Val 
    690                 695                 700                 


Phe Val Asp Trp Ile Asn Lys Val Met Gln Leu Glu 
705                 710                 715     


<210>  15
<211>  801
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(801)

<400>  15
atg tgg gtg acc aaa ctc ctg cca gcc ctg ctg ctg cag cat gtc ctc         48
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu           
1               5                   10                  15                

ctg cat ctc ctc ctg ctc ccc atc gcc atc ccc tat gca gag gga gtg         96
Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val           
            20                  25                  30                    

gtg gga ggc cat cct ggg aac tcc cca tgg acg gtc agc ttg cgg aat        144
Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn           
        35                  40                  45                        

cga cag ggc cag cat ttc tgt ggg ggc tcc cta gtg aag gag cag tgg        192
Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp           
    50                  55                  60                            

gta ctg act gcc cgg caa tgc atc tgg tca tgc cac gaa cct ctc aca        240
Val Leu Thr Ala Arg Gln Cys Ile Trp Ser Cys His Glu Pro Leu Thr           
65                  70                  75                  80            

gga tac gag gta tgg ttg ggt aca att aac cag aac cca cag cct gga        288
Gly Tyr Glu Val Trp Leu Gly Thr Ile Asn Gln Asn Pro Gln Pro Gly           
                85                  90                  95                

gag gca aac ctg cag agg gtc cca gtg gcc aag gca gtg tgc ggc cct        336
Glu Ala Asn Leu Gln Arg Val Pro Val Ala Lys Ala Val Cys Gly Pro           
            100                 105                 110                   

gca ggc tcc cag ctt gtt ctg ctc aag ctg gag aga cct gtg atc ctg        384
Ala Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Pro Val Ile Leu           
        115                 120                 125                       

aac cat cac gtg gcc ctg att gcc ctg cct cct gaa cag tat gtg gta        432
Asn His His Val Ala Leu Ile Ala Leu Pro Pro Glu Gln Tyr Val Val           
    130                 135                 140                           

cct cca ggg acc aag tgt gag atc gca ggc tgg ggt gaa tcc atc ggt        480
Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Ser Ile Gly           
145                 150                 155                 160           

aca agc aat aac aca gtc ctt cat gtg gcc tcg atg aat gtc atc tcc        528
Thr Ser Asn Asn Thr Val Leu His Val Ala Ser Met Asn Val Ile Ser           
                165                 170                 175               

aac cag gaa tgt aac acg aag tac cga gga cac ata caa gag agt gag        576
Asn Gln Glu Cys Asn Thr Lys Tyr Arg Gly His Ile Gln Glu Ser Glu           
            180                 185                 190                   

ata tgc acc cag gga ctg gtg gtc cct gtg ggg gct tgt gag ggt gac        624
Ile Cys Thr Gln Gly Leu Val Val Pro Val Gly Ala Cys Glu Gly Asp           
        195                 200                 205                       

tac ggg ggc cca ctt gcc tgc tat acc cat gac gca tgg gtc cta cag        672
Tyr Gly Gly Pro Leu Ala Cys Tyr Thr His Asp Ala Trp Val Leu Gln           
    210                 215                 220                           

gga ctt atc atc ccg aac aga gtg tgt gca cgg ccc cgc tgg cca gct        720
Gly Leu Ile Ile Pro Asn Arg Val Cys Ala Arg Pro Arg Trp Pro Ala           
225                 230                 235                 240           

atc ttc aca cgg gtg tct gtg ttc gtg gac tgg att aac aag gtc atg        768
Ile Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile Asn Lys Val Met           
                245                 250                 255               

ctg gag cat cat cat cat cat cat cat cat tga                            801
Leu Glu His His His His His His His His                                   
            260                 265                                       


<210>  16
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val 
            20                  25                  30          


Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn 
        35                  40                  45              


Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp 
    50                  55                  60                  


Val Leu Thr Ala Arg Gln Cys Ile Trp Ser Cys His Glu Pro Leu Thr 
65                  70                  75                  80  


Gly Tyr Glu Val Trp Leu Gly Thr Ile Asn Gln Asn Pro Gln Pro Gly 
                85                  90                  95      


Glu Ala Asn Leu Gln Arg Val Pro Val Ala Lys Ala Val Cys Gly Pro 
            100                 105                 110         


Ala Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Pro Val Ile Leu 
        115                 120                 125             


Asn His His Val Ala Leu Ile Ala Leu Pro Pro Glu Gln Tyr Val Val 
    130                 135                 140                 


Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Ser Ile Gly 
145                 150                 155                 160 


Thr Ser Asn Asn Thr Val Leu His Val Ala Ser Met Asn Val Ile Ser 
                165                 170                 175     


Asn Gln Glu Cys Asn Thr Lys Tyr Arg Gly His Ile Gln Glu Ser Glu 
            180                 185                 190         


Ile Cys Thr Gln Gly Leu Val Val Pro Val Gly Ala Cys Glu Gly Asp 
        195                 200                 205             


Tyr Gly Gly Pro Leu Ala Cys Tyr Thr His Asp Ala Trp Val Leu Gln 
    210                 215                 220                 


Gly Leu Ile Ile Pro Asn Arg Val Cys Ala Arg Pro Arg Trp Pro Ala 
225                 230                 235                 240 


Ile Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile Asn Lys Val Met 
                245                 250                 255     


Leu Glu His His His His His His His His 
            260                 265     


<210>  17
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  17

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val 
            20                  25                  30          


Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn 
        35                  40                  45              


Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp 
    50                  55                  60                  


Val Leu Thr Ala Arg Gln Cys Ile Trp Ser Cys His Glu Pro Leu Thr 
65                  70                  75                  80  


Gly Tyr Glu Val Trp Leu Gly Thr Ile Asn Gln Asn Pro Gln Pro Gly 
                85                  90                  95      


Glu Ala Asn Leu Gln Arg Val Pro Val Ala Lys Ala Val Cys Gly Pro 
            100                 105                 110         


Ala Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Pro Val Ile Leu 
        115                 120                 125             


Asn His His Val Ala Leu Ile Ala Leu Pro Pro Glu Gln Tyr Val Val 
    130                 135                 140                 


Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Ser Ile Gly 
145                 150                 155                 160 


Thr Ser Asn Asn Thr Val Leu His Val Ala Ser Met Asn Val Ile Ser 
                165                 170                 175     


Asn Gln Glu Cys Asn Thr Lys Tyr Arg Gly His Ile Gln Glu Ser Glu 
            180                 185                 190         


Ile Cys Thr Gln Gly Leu Val Val Pro Val Gly Ala Cys Glu Gly Asp 
        195                 200                 205             


Tyr Gly Gly Pro Leu Ala Cys Tyr Thr His Asp Cys Trp Val Leu Gln 
    210                 215                 220                 


Gly Leu Ile Ile Pro Asn Arg Val Cys Ala Arg Pro Arg Trp Pro Ala 
225                 230                 235                 240 


Ile Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile Asn Lys Val Met 
                245                 250                 255     


Leu Glu His His His His His His His His 
            260                 265     


<210>  18
<211>  716
<212>  PRT
<213>  Mus musculus

<400>  18

Met Gly Trp Leu Pro Leu Leu Leu Leu Leu Val Gln Cys Ser Arg Ala 
1               5                   10                  15      


Leu Gly Gln Arg Ser Pro Leu Asn Asp Phe Gln Leu Phe Arg Gly Thr 
            20                  25                  30          


Glu Leu Arg Asn Leu Leu His Thr Ala Val Pro Gly Pro Trp Gln Glu 
        35                  40                  45              


Asp Val Ala Asp Ala Glu Glu Cys Ala Arg Arg Cys Gly Pro Leu Leu 
    50                  55                  60                  


Asp Cys Arg Ala Phe His Tyr Asn Met Ser Ser His Gly Cys Gln Leu 
65                  70                  75                  80  


Leu Pro Trp Thr Gln His Ser Leu His Thr Gln Leu Tyr His Ser Ser 
                85                  90                  95      


Leu Cys His Leu Phe Gln Lys Lys Asp Tyr Val Arg Thr Cys Ile Met 
            100                 105                 110         


Asp Asn Gly Val Ser Tyr Arg Gly Thr Val Ala Arg Thr Ala Gly Gly 
        115                 120                 125             


Leu Pro Cys Gln Ala Trp Ser Arg Arg Phe Pro Asn Asp His Lys Tyr 
    130                 135                 140                 


Thr Pro Thr Pro Lys Asn Gly Leu Glu Glu Asn Phe Cys Arg Asn Pro 
145                 150                 155                 160 


Asp Gly Asp Pro Arg Gly Pro Trp Cys Tyr Thr Thr Asn Arg Ser Val 
                165                 170                 175     


Arg Phe Gln Ser Cys Gly Ile Lys Thr Cys Arg Glu Ala Val Cys Val 
            180                 185                 190         


Leu Cys Asn Gly Glu Asp Tyr Arg Gly Glu Val Asp Val Thr Glu Ser 
        195                 200                 205             


Gly Arg Glu Cys Gln Arg Trp Asp Leu Gln His Pro His Ser His Pro 
    210                 215                 220                 


Phe Gln Pro Glu Lys Phe Leu Asp Lys Asp Leu Lys Asp Asn Tyr Cys 
225                 230                 235                 240 


Arg Asn Pro Asp Gly Ser Glu Arg Pro Trp Cys Tyr Thr Thr Asp Pro 
                245                 250                 255     


Asn Val Glu Arg Glu Phe Cys Asp Leu Pro Ser Cys Gly Pro Asn Leu 
            260                 265                 270         


Pro Pro Thr Val Lys Gly Ser Lys Ser Gln Arg Arg Asn Lys Gly Lys 
        275                 280                 285             


Ala Leu Asn Cys Phe Arg Gly Lys Gly Glu Asp Tyr Arg Gly Thr Thr 
    290                 295                 300                 


Asn Thr Thr Ser Ala Gly Val Pro Cys Gln Arg Trp Asp Ala Gln Ser 
305                 310                 315                 320 


Pro His Gln His Arg Phe Val Pro Glu Lys Tyr Ala Cys Lys Asp Leu 
                325                 330                 335     


Arg Glu Asn Phe Cys Arg Asn Pro Asp Gly Ser Glu Ala Pro Trp Cys 
            340                 345                 350         


Phe Thr Ser Arg Pro Gly Leu Arg Met Ala Phe Cys His Gln Ile Pro 
        355                 360                 365             


Arg Cys Thr Glu Glu Leu Val Pro Glu Gly Cys Tyr His Gly Ser Gly 
    370                 375                 380                 


Glu Gln Tyr Arg Gly Ser Val Ser Lys Thr Arg Lys Gly Val Gln Cys 
385                 390                 395                 400 


Gln His Trp Ser Ser Glu Thr Pro His Lys Pro Gln Phe Thr Pro Thr 
                405                 410                 415     


Ser Ala Pro Gln Ala Gly Leu Glu Ala Asn Phe Cys Arg Asn Pro Asp 
            420                 425                 430         


Gly Asp Ser His Gly Pro Trp Cys Tyr Thr Leu Asp Pro Asp Ile Leu 
        435                 440                 445             


Phe Asp Tyr Cys Ala Leu Gln Arg Cys Asp Asp Asp Gln Pro Pro Ser 
    450                 455                 460                 


Ile Leu Asp Pro Pro Asp Gln Val Val Phe Glu Lys Cys Gly Lys Arg 
465                 470                 475                 480 


Val Asp Lys Ser Asn Lys Leu Arg Val Val Gly Gly His Pro Gly Asn 
                485                 490                 495     


Ser Pro Trp Thr Val Ser Leu Arg Asn Arg Gln Gly Gln His Phe Cys 
            500                 505                 510         


Gly Gly Ser Leu Val Lys Glu Gln Trp Val Leu Thr Ala Arg Gln Cys 
        515                 520                 525             


Ile Trp Ser Cys His Glu Pro Leu Thr Gly Tyr Glu Val Trp Leu Gly 
    530                 535                 540                 


Thr Ile Asn Gln Asn Pro Gln Pro Gly Glu Ala Asn Leu Gln Arg Val 
545                 550                 555                 560 


Pro Val Ala Lys Ala Val Cys Gly Pro Ala Gly Ser Gln Leu Val Leu 
                565                 570                 575     


Leu Lys Leu Glu Arg Pro Val Ile Leu Asn His His Val Ala Leu Ile 
            580                 585                 590         


Cys Leu Pro Pro Glu Gln Tyr Val Val Pro Pro Gly Thr Lys Cys Glu 
        595                 600                 605             


Ile Ala Gly Trp Gly Glu Ser Ile Gly Thr Ser Asn Asn Thr Val Leu 
    610                 615                 620                 


His Val Ala Ser Met Asn Val Ile Ser Asn Gln Glu Cys Asn Thr Lys 
625                 630                 635                 640 


Tyr Arg Gly His Ile Gln Glu Ser Glu Ile Cys Thr Gln Gly Leu Val 
                645                 650                 655     


Val Pro Val Gly Ala Cys Glu Gly Asp Tyr Gly Gly Pro Leu Ala Cys 
            660                 665                 670         


Tyr Thr His Asp Cys Trp Val Leu Gln Gly Leu Ile Ile Pro Asn Arg 
        675                 680                 685             


Val Cys Ala Arg Pro Arg Trp Pro Ala Ile Phe Thr Arg Val Ser Val 
    690                 695                 700                 


Phe Val Asp Trp Ile Asn Lys Val Met Gln Leu Glu 
705                 710                 715     


<210>  19
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(1482)

<400>  19
atg tgg gtg acc aaa ctc ctg cca gcc ctg ctg ctg cag cat gtc ctc         48
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu           
1               5                   10                  15                

ctg cat ctc ctc ctg ctc ccc atc gcc atc ccc tat gca gag gga gtg         96
Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val           
            20                  25                  30                    

gtt ggg ggc cat ccg ggc aac tca ccc tgg aca gtc agc ttg cgg aat        144
Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn           
        35                  40                  45                        

cgg cag ggc cag cat ttc tgc ggg ggg tct cta gtg aag gag cag tgg        192
Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp           
    50                  55                  60                            

ata ctg act gcc cgg cag tgc ttc tcc tcc tgc cat atg cct ctc acg        240
Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser Cys His Met Pro Leu Thr           
65                  70                  75                  80            

ggc tat gag gta tgg ttg ggc acc ctg ttc cag aac cca cag cat gga        288
Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe Gln Asn Pro Gln His Gly           
                85                  90                  95                

gag cca agc cta cag cgg gtc cca gta gcc aag atg gtg tgt ggg ccc        336
Glu Pro Ser Leu Gln Arg Val Pro Val Ala Lys Met Val Cys Gly Pro           
            100                 105                 110                   

tca ggc tcc cag ctt gtc ctg ctc aag ctg gag aga tct gtg acc ctg        384
Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Ser Val Thr Leu           
        115                 120                 125                       

aac cag cgt gtg gcc ctg atc tcc ctg ccc cct gaa tgg tat gtg gtg        432
Asn Gln Arg Val Ala Leu Ile Ser Leu Pro Pro Glu Trp Tyr Val Val           
    130                 135                 140                           

cct cca ggg acc aag tgt gag att gca ggc tgg ggt gag acc aaa ggt        480
Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Thr Lys Gly           
145                 150                 155                 160           

acg ggt aat gac aca gtc cta aat gtg gcc ttg ctg aat gtc atc tcc        528
Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu Asn Val Ile Ser           
                165                 170                 175               

aac cag gag tgt aac atc aag cac cga gga cgt gtg cgg gag agt gag        576
Asn Gln Glu Cys Asn Ile Lys His Arg Gly Arg Val Arg Glu Ser Glu           
            180                 185                 190                   

atg tgc act gag gga ctg ttg gcc cct gtg ggg gcc tgt gag ggt gac        624
Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly Ala Cys Glu Gly Asp           
        195                 200                 205                       

tac ggg ggc cca ctt gcc tgc ttt acc cac aac gcc tgg gtc ctg gaa        672
Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn Ala Trp Val Leu Glu           
    210                 215                 220                           

gga att ata atc ccc aac cga gta tgc gca agg tcc cgc tgg cca gct        720
Gly Ile Ile Ile Pro Asn Arg Val Cys Ala Arg Ser Arg Trp Pro Ala           
225                 230                 235                 240           

gtc ttc acg cgt gtc tct gtg ttt gtg gac tgg att cac aag gtc atg        768
Val Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile His Lys Val Met           
                245                 250                 255               

aga ctg ggt tcc gga gga tcc cag gtc acc gac aaa act cac aca tgc        816
Arg Leu Gly Ser Gly Gly Ser Gln Val Thr Asp Lys Thr His Thr Cys           
            260                 265                 270                   

cca ccg tgc cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc        864
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu           
        275                 280                 285                       

ttc ccc cca aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag        912
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu           
    290                 295                 300                           

gtc aca tgc gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag        960
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys           
305                 310                 315                 320           

ttc aac tgg tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag       1008
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys           
                325                 330                 335               

ccg cgg gag gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc       1056
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu           
            340                 345                 350                   

acc gtc ctg cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag       1104
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys           
        355                 360                 365                       

gtc tcc aac aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa       1152
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys           
    370                 375                 380                           

gcc aaa ggg cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc       1200
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser           
385                 390                 395                 400           

cgg gaa gag atg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa       1248
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys           
                405                 410                 415               

ggc ttc tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag       1296
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln           
            420                 425                 430                   

ccg gag aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc       1344
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly           
        435                 440                 445                       

tcc ttc ttc ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag       1392
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln           
    450                 455                 460                           

cag ggg aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac       1440
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn           
465                 470                 475                 480           

cac tac acg cag aag agc ctc tcc ctg tct ccg ggt aaa tga               1482
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                       
                485                 490                                   


<210>  20
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val 
            20                  25                  30          


Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn 
        35                  40                  45              


Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp 
    50                  55                  60                  


Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser Cys His Met Pro Leu Thr 
65                  70                  75                  80  


Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe Gln Asn Pro Gln His Gly 
                85                  90                  95      


Glu Pro Ser Leu Gln Arg Val Pro Val Ala Lys Met Val Cys Gly Pro 
            100                 105                 110         


Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Ser Val Thr Leu 
        115                 120                 125             


Asn Gln Arg Val Ala Leu Ile Ser Leu Pro Pro Glu Trp Tyr Val Val 
    130                 135                 140                 


Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Thr Lys Gly 
145                 150                 155                 160 


Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu Asn Val Ile Ser 
                165                 170                 175     


Asn Gln Glu Cys Asn Ile Lys His Arg Gly Arg Val Arg Glu Ser Glu 
            180                 185                 190         


Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly Ala Cys Glu Gly Asp 
        195                 200                 205             


Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn Ala Trp Val Leu Glu 
    210                 215                 220                 


Gly Ile Ile Ile Pro Asn Arg Val Cys Ala Arg Ser Arg Trp Pro Ala 
225                 230                 235                 240 


Val Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile His Lys Val Met 
                245                 250                 255     


Arg Leu Gly Ser Gly Gly Ser Gln Val Thr Asp Lys Thr His Thr Cys 
            260                 265                 270         


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        275                 280                 285             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    290                 295                 300                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
305                 310                 315                 320 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                325                 330                 335     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            340                 345                 350         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        355                 360                 365             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    370                 375                 380                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
385                 390                 395                 400 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                405                 410                 415     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            420                 425                 430         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        435                 440                 445             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    450                 455                 460                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
465                 470                 475                 480 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490             


<210>  21
<211>  1500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(1500)

<400>  21
atg tgg gtg acc aaa ctc ctg cca gcc ctg ctg ctg cag cat gtc ctc         48
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu           
1               5                   10                  15                

ctg cat ctc ctc ctg ctc ccc atc gcc atc ccc tat gca gag gga gtg         96
Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val           
            20                  25                  30                    

gtt ggg ggc cat ccg ggc aac tca ccc tgg aca gtc agc ttg cgg aat        144
Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn           
        35                  40                  45                        

cgg cag ggc cag cat ttc tgc ggg ggg tct cta gtg aag gag cag tgg        192
Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp           
    50                  55                  60                            

ata ctg act gcc cgg cag tgc ttc tcc tcc tgc cat atg cct ctc acg        240
Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser Cys His Met Pro Leu Thr           
65                  70                  75                  80            

ggc tat gag gta tgg ttg ggc acc ctg ttc cag aac cca cag cat gga        288
Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe Gln Asn Pro Gln His Gly           
                85                  90                  95                

gag cca agc cta cag cgg gtc cca gta gcc aag atg gtg tgt ggg ccc        336
Glu Pro Ser Leu Gln Arg Val Pro Val Ala Lys Met Val Cys Gly Pro           
            100                 105                 110                   

tca ggc tcc cag ctt gtc ctg ctc aag ctg gag aga tct gtg acc ctg        384
Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Ser Val Thr Leu           
        115                 120                 125                       

aac cag cgt gtg gcc ctg atc tcc ctg ccc cct gaa tgg tat gtg gtg        432
Asn Gln Arg Val Ala Leu Ile Ser Leu Pro Pro Glu Trp Tyr Val Val           
    130                 135                 140                           

cct cca ggg acc aag tgt gag att gca ggc tgg ggt gag acc aaa ggt        480
Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Thr Lys Gly           
145                 150                 155                 160           

acg ggt aat gac aca gtc cta aat gtg gcc ttg ctg aat gtc atc tcc        528
Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu Asn Val Ile Ser           
                165                 170                 175               

aac cag gag tgt aac atc aag cac cga gga cgt gtg cgg gag agt gag        576
Asn Gln Glu Cys Asn Ile Lys His Arg Gly Arg Val Arg Glu Ser Glu           
            180                 185                 190                   

atg tgc act gag gga ctg ttg gcc cct gtg ggg gcc tgt gag ggt gac        624
Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly Ala Cys Glu Gly Asp           
        195                 200                 205                       

tac ggg ggc cca ctt gcc tgc ttt acc cac aac gcc tgg gtc ctg gaa        672
Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn Ala Trp Val Leu Glu           
    210                 215                 220                           

gga att ata atc ccc aac cga gta tgc gca agg tcc cgc tgg cca gct        720
Gly Ile Ile Ile Pro Asn Arg Val Cys Ala Arg Ser Arg Trp Pro Ala           
225                 230                 235                 240           

gtc ttc acg cgt gtc tct gtg ttt gtg gac tgg att cac aag gtc atg        768
Val Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile His Lys Val Met           
                245                 250                 255               

aga ctg ggt cag gtc acc gac aag aaa att gag ccc aga ggg ccc aca        816
Arg Leu Gly Gln Val Thr Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr           
            260                 265                 270                   

atc aag ccc tgt cct cca tgc aaa tgc cca gca cct aac ctc ttg ggt        864
Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly           
        275                 280                 285                       

gga cca tcc gtc ttc atc ttc cct cca aag atc aag gat gta ctc atg        912
Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met           
    290                 295                 300                           

atc tcc ctg agc ccc ata gtc aca tgt gtg gtg gtg gat gtg agc gag        960
Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu           
305                 310                 315                 320           

gat gac cca gat gtc cag atc agc tgg ttt gtg aac aac gtg gaa gta       1008
Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val           
                325                 330                 335               

cac aca gct cag aca caa acc cat aga gag gat tac aac agt act cta       1056
His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu           
            340                 345                 350                   

cgc gtg gtc agt gcc ctc ccc atc cag cac cag gac tgg atg agt ggc       1104
Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly           
        355                 360                 365                       

aag gag ttc aaa tgc aag gtc aac aac aaa gac ctc cca gcg ccc atc       1152
Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile           
    370                 375                 380                           

gag aga acc atc tca aaa ccc aaa ggg tca gta aga gct cca cag gta       1200
Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val           
385                 390                 395                 400           

tat gtc ttg cct cca cca gaa gaa gag atg act aag aaa cag gtc act       1248
Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr           
                405                 410                 415               

ctg acc tgc atg gtc aca gac ttc atg cct gaa gac att tac gtg gag       1296
Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu           
            420                 425                 430                   

tgg acc aac aac ggg aaa aca gag cta aac tac aag aac act gaa cca       1344
Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro           
        435                 440                 445                       

gtc ctg gac tct gat ggt tct tac ttc atg tac agc aag ctg aga gtg       1392
Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val           
    450                 455                 460                           

gaa aag aag aac tgg gtg gaa aga aat agc tac tcc tgt tca gtg gtc       1440
Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val           
465                 470                 475                 480           

cac gag ggt ctg cac aat cac cac acg act aag agc ttc tcc cgg act       1488
His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr           
                485                 490                 495               

ccg ggt aaa tga                                                       1500
Pro Gly Lys                                                               
                                                                          


<210>  22
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val 
            20                  25                  30          


Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn 
        35                  40                  45              


Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp 
    50                  55                  60                  


Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser Cys His Met Pro Leu Thr 
65                  70                  75                  80  


Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe Gln Asn Pro Gln His Gly 
                85                  90                  95      


Glu Pro Ser Leu Gln Arg Val Pro Val Ala Lys Met Val Cys Gly Pro 
            100                 105                 110         


Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Ser Val Thr Leu 
        115                 120                 125             


Asn Gln Arg Val Ala Leu Ile Ser Leu Pro Pro Glu Trp Tyr Val Val 
    130                 135                 140                 


Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Thr Lys Gly 
145                 150                 155                 160 


Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu Asn Val Ile Ser 
                165                 170                 175     


Asn Gln Glu Cys Asn Ile Lys His Arg Gly Arg Val Arg Glu Ser Glu 
            180                 185                 190         


Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly Ala Cys Glu Gly Asp 
        195                 200                 205             


Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn Ala Trp Val Leu Glu 
    210                 215                 220                 


Gly Ile Ile Ile Pro Asn Arg Val Cys Ala Arg Ser Arg Trp Pro Ala 
225                 230                 235                 240 


Val Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile His Lys Val Met 
                245                 250                 255     


Arg Leu Gly Gln Val Thr Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr 
            260                 265                 270         


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
    290                 295                 300                 


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
305                 310                 315                 320 


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
                325                 330                 335     


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
            340                 345                 350         


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
        355                 360                 365             


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
385                 390                 395                 400 


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
                405                 410                 415     


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
            420                 425                 430         


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
    450                 455                 460                 


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
465                 470                 475                 480 


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
                485                 490                 495     


Pro Gly Lys 
            


<210>  23
<211>  1500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(1500)

<400>  23
atg tgg gtg acc aaa ctc ctg cca gcc ctg ctg ctg cag cat gtc ctc         48
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu           
1               5                   10                  15                

ctg cat ctc ctc ctg ctc ccc atc gcc atc ccc tat gca gag gga gtg         96
Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val           
            20                  25                  30                    

gtt ggg ggc cat ccg ggc aac tca ccc tgg aca gtc agc ttg cgg aat        144
Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn           
        35                  40                  45                        

cgg cag ggc cag cat ttc tgc ggg ggg tct cta gtg aag gag cag tgg        192
Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp           
    50                  55                  60                            

ata ctg act gcc cgg cag tgc ttc tcc tcc tgc cat atg cct ctc acg        240
Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser Cys His Met Pro Leu Thr           
65                  70                  75                  80            

ggc tat gag gta tgg ttg ggc acc ctg ttc cag aac cca cag cat gga        288
Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe Gln Asn Pro Gln His Gly           
                85                  90                  95                

gag cca agc cta cag cgg gtc cca gta gcc aag atg gtg tgt ggg ccc        336
Glu Pro Ser Leu Gln Arg Val Pro Val Ala Lys Met Val Cys Gly Pro           
            100                 105                 110                   

tca ggc tcc cag ctt gtc ctg ctc aag ctg gag aga tct gtg acc ctg        384
Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Ser Val Thr Leu           
        115                 120                 125                       

aac cag cgt gtg gcc ctg atc tcc ctg ccc cct gaa tgg tat gtg gtg        432
Asn Gln Arg Val Ala Leu Ile Ser Leu Pro Pro Glu Trp Tyr Val Val           
    130                 135                 140                           

cct cca ggg acc aag tgt gag att gca ggc tgg ggt gag acc aaa ggt        480
Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Thr Lys Gly           
145                 150                 155                 160           

acg ggt aat gac aca gtc cta aat gtg gcc ttg ctg aat gtc atc tcc        528
Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu Asn Val Ile Ser           
                165                 170                 175               

aac cag gag tgt aac atc aag cac cga gga cgt gtg cgg gag agt gag        576
Asn Gln Glu Cys Asn Ile Lys His Arg Gly Arg Val Arg Glu Ser Glu           
            180                 185                 190                   

atg tgc act gag gga ctg ttg gcc cct gtg ggg gcc tgt gag ggt gac        624
Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly Ala Cys Glu Gly Asp           
        195                 200                 205                       

tac ggg ggc cca ctt gcc tgc ttt acc cac aac tcc tgg gtc ctg gaa        672
Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn Ser Trp Val Leu Glu           
    210                 215                 220                           

gga att ata atc ccc aac cga gta tgc gca agg tcc cgc tgg cca gct        720
Gly Ile Ile Ile Pro Asn Arg Val Cys Ala Arg Ser Arg Trp Pro Ala           
225                 230                 235                 240           

gtc ttc acg cgt gtc tct gtg ttt gtg gac tgg att cac aag gtc atg        768
Val Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile His Lys Val Met           
                245                 250                 255               

aga ctg ggt cag gtc acc gac aag aaa att gag ccc aga gga ccc aca        816
Arg Leu Gly Gln Val Thr Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr           
            260                 265                 270                   

atc aag ccc tgt cct cca tgc aaa tgc cca gca cct aac ctc ttg ggt        864
Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly           
        275                 280                 285                       

gga cca tcc gtc ttc atc ttc cct cca aag atc aag gat gta ctc atg        912
Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met           
    290                 295                 300                           

atc tcc ctg agc ccc ata gtc aca tgt gtg gtg gtg gct gtg agc gag        960
Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Ala Val Ser Glu           
305                 310                 315                 320           

gat gac cca gat gtc cag atc agc tgg ttt gtg aac aac gtg gaa gta       1008
Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val           
                325                 330                 335               

cac aca gct cag aca caa acc cat aga gag gat tac gcc agt act cta       1056
His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Ala Ser Thr Leu           
            340                 345                 350                   

cgc gtg gtc agt gcc ctc ccc atc cag cac cag gac tgg atg agt ggc       1104
Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly           
        355                 360                 365                       

aag gag ttc aaa tgc aag gtc aac aac aaa gac ctc cca gcg ccc atc       1152
Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile           
    370                 375                 380                           

gag aga acc atc tca aaa ccc aaa ggg tca gta aga gct cca cag gta       1200
Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val           
385                 390                 395                 400           

tat gtc ttg cct cca cca gaa gaa gag atg act aag aaa cag gtc act       1248
Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr           
                405                 410                 415               

ctg acc tgc atg gtc aca gac ttc atg cct gaa gac att tac gtg gag       1296
Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu           
            420                 425                 430                   

tgg acc aac aac ggg aaa aca gag cta aac tac aag aac act gaa cca       1344
Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro           
        435                 440                 445                       

gtc ctg gac tct gat ggt tct tac ttc atg tac agc aag ctg aga gtg       1392
Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val           
    450                 455                 460                           

gaa aag aag aac tgg gtg gaa aga aat agc tac tcc tgt tca gtg gtc       1440
Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val           
465                 470                 475                 480           

cac gag ggt ctg cac aat cac cac acg act aag agc ttc tcc cgg act       1488
His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr           
                485                 490                 495               

ccg ggt aaa tga                                                       1500
Pro Gly Lys                                                               
                                                                          


<210>  24
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val 
            20                  25                  30          


Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn 
        35                  40                  45              


Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp 
    50                  55                  60                  


Ile Leu Thr Ala Arg Gln Cys Phe Ser Ser Cys His Met Pro Leu Thr 
65                  70                  75                  80  


Gly Tyr Glu Val Trp Leu Gly Thr Leu Phe Gln Asn Pro Gln His Gly 
                85                  90                  95      


Glu Pro Ser Leu Gln Arg Val Pro Val Ala Lys Met Val Cys Gly Pro 
            100                 105                 110         


Ser Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Ser Val Thr Leu 
        115                 120                 125             


Asn Gln Arg Val Ala Leu Ile Ser Leu Pro Pro Glu Trp Tyr Val Val 
    130                 135                 140                 


Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Thr Lys Gly 
145                 150                 155                 160 


Thr Gly Asn Asp Thr Val Leu Asn Val Ala Leu Leu Asn Val Ile Ser 
                165                 170                 175     


Asn Gln Glu Cys Asn Ile Lys His Arg Gly Arg Val Arg Glu Ser Glu 
            180                 185                 190         


Met Cys Thr Glu Gly Leu Leu Ala Pro Val Gly Ala Cys Glu Gly Asp 
        195                 200                 205             


Tyr Gly Gly Pro Leu Ala Cys Phe Thr His Asn Ser Trp Val Leu Glu 
    210                 215                 220                 


Gly Ile Ile Ile Pro Asn Arg Val Cys Ala Arg Ser Arg Trp Pro Ala 
225                 230                 235                 240 


Val Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile His Lys Val Met 
                245                 250                 255     


Arg Leu Gly Gln Val Thr Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr 
            260                 265                 270         


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
    290                 295                 300                 


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Ala Val Ser Glu 
305                 310                 315                 320 


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
                325                 330                 335     


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Ala Ser Thr Leu 
            340                 345                 350         


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
        355                 360                 365             


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
385                 390                 395                 400 


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
                405                 410                 415     


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
            420                 425                 430         


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
    450                 455                 460                 


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
465                 470                 475                 480 


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
                485                 490                 495     


Pro Gly Lys 
            


<210>  25
<211>  1464
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(1464)

<400>  25
atg tgg gtg acc aaa ctc ctg cca gcc ctg ctg ctg cag cat gtc ctc         48
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu           
1               5                   10                  15                

ctg cat ctc ctc ctg ctc ccc atc gcc atc ccc tat gca gag gga gtg         96
Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val           
            20                  25                  30                    

gtg gga ggc cat cct ggg aac tcc cca tgg acg gtc agc ttg cgg aat        144
Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn           
        35                  40                  45                        

cga cag ggc cag cat ttc tgt ggg ggc tcc cta gtg aag gag cag tgg        192
Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp           
    50                  55                  60                            

gta ctg act gcc cgg caa tgc atc tgg tca tgc cac gaa cct ctc aca        240
Val Leu Thr Ala Arg Gln Cys Ile Trp Ser Cys His Glu Pro Leu Thr           
65                  70                  75                  80            

gga tac gag gta tgg ttg ggt aca att aac cag aac cca cag cct gga        288
Gly Tyr Glu Val Trp Leu Gly Thr Ile Asn Gln Asn Pro Gln Pro Gly           
                85                  90                  95                

gag gca aac ctg cag agg gtc cca gtg gcc aag gca gtg tgc ggc cct        336
Glu Ala Asn Leu Gln Arg Val Pro Val Ala Lys Ala Val Cys Gly Pro           
            100                 105                 110                   

gca ggc tcc cag ctt gtt ctg ctc aag ctg gag aga cct gtg atc ctg        384
Ala Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Pro Val Ile Leu           
        115                 120                 125                       

aac cat cac gtg gcc ctg att gcc ctg cct cct gaa cag tat gtg gta        432
Asn His His Val Ala Leu Ile Ala Leu Pro Pro Glu Gln Tyr Val Val           
    130                 135                 140                           

cct cca ggg acc aag tgt gag atc gca ggc tgg ggt gaa tcc atc ggt        480
Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Ser Ile Gly           
145                 150                 155                 160           

aca agc aat aac aca gtc ctt cat gtg gcc tcg atg aat gtc atc tcc        528
Thr Ser Asn Asn Thr Val Leu His Val Ala Ser Met Asn Val Ile Ser           
                165                 170                 175               

aac cag gaa tgt aac acg aag tac cga gga cac ata caa gag agt gag        576
Asn Gln Glu Cys Asn Thr Lys Tyr Arg Gly His Ile Gln Glu Ser Glu           
            180                 185                 190                   

ata tgc acc cag gga ctg gtg gtc cct gtg ggg gct tgt gag ggt gac        624
Ile Cys Thr Gln Gly Leu Val Val Pro Val Gly Ala Cys Glu Gly Asp           
        195                 200                 205                       

tac ggg ggc cca ctt gcc tgc tat acc cat gac gca tgg gtc cta cag        672
Tyr Gly Gly Pro Leu Ala Cys Tyr Thr His Asp Ala Trp Val Leu Gln           
    210                 215                 220                           

gga ctt atc atc ccg aac aga gtg tgt gca cgg ccc cgc tgg cca gct        720
Gly Leu Ile Ile Pro Asn Arg Val Cys Ala Arg Pro Arg Trp Pro Ala           
225                 230                 235                 240           

atc ttc aca cgg gtg tct gtg ttc gtg gac tgg att aac aag gtc atg        768
Ile Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile Asn Lys Val Met           
                245                 250                 255               

cag ctg gag aca atc aag ccc tgt cct cca tgc aaa tgc cca gca cct        816
Gln Leu Glu Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro           
            260                 265                 270                   

aac ctc ttg ggt gga cca tcc gtc ttc atc ttc cct cca aag atc aag        864
Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys           
        275                 280                 285                       

gat gta ctc atg atc tcc ctg agc ccc ata gtc aca tgt gtg gtg gtg        912
Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val           
    290                 295                 300                           

gat gtg agc gag gat gac cca gat gtc cag atc agc tgg ttt gtg aac        960
Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn           
305                 310                 315                 320           

aac gtg gaa gta cac aca gct cag aca caa acc cat aga gag gat tac       1008
Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr           
                325                 330                 335               

aac agt act cta cgc gtg gtc agt gcc ctc ccc atc cag cac cag gac       1056
Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp           
            340                 345                 350                   

tgg atg agt ggc aag gag ttc aaa tgc aag gtc aac aac aaa gac ctc       1104
Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu           
        355                 360                 365                       

cca gcg ccc atc gag aga acc atc tca aaa ccc aaa ggg tca gta aga       1152
Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg           
    370                 375                 380                           

gct cca cag gta tat gtc ttg cct cca cca gaa gaa gag atg act aag       1200
Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys           
385                 390                 395                 400           

aaa cag gtc act ctg acc tgc atg gtc aca gac ttc atg cct gaa gac       1248
Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp           
                405                 410                 415               

att tac gtg gag tgg acc aac aac ggg aaa aca gag cta aac tac aag       1296
Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys           
            420                 425                 430                   

aac act gaa cca gtc ctg gac tct gat ggt tct tac ttc atg tac agc       1344
Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser           
        435                 440                 445                       

aag ctg aga gtg gaa aag aag aac tgg gtg gaa aga aat agc tac tcc       1392
Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser           
    450                 455                 460                           

tgt tca gtg gtc cac gag ggt ctg cac aat cac cac acg act aag agc       1440
Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser           
465                 470                 475                 480           

ttc tcc cgg act ccg ggt aaa tga                                       1464
Phe Ser Arg Thr Pro Gly Lys                                               
                485                                                       


<210>  26
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val 
            20                  25                  30          


Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn 
        35                  40                  45              


Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp 
    50                  55                  60                  


Val Leu Thr Ala Arg Gln Cys Ile Trp Ser Cys His Glu Pro Leu Thr 
65                  70                  75                  80  


Gly Tyr Glu Val Trp Leu Gly Thr Ile Asn Gln Asn Pro Gln Pro Gly 
                85                  90                  95      


Glu Ala Asn Leu Gln Arg Val Pro Val Ala Lys Ala Val Cys Gly Pro 
            100                 105                 110         


Ala Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Pro Val Ile Leu 
        115                 120                 125             


Asn His His Val Ala Leu Ile Ala Leu Pro Pro Glu Gln Tyr Val Val 
    130                 135                 140                 


Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Ser Ile Gly 
145                 150                 155                 160 


Thr Ser Asn Asn Thr Val Leu His Val Ala Ser Met Asn Val Ile Ser 
                165                 170                 175     


Asn Gln Glu Cys Asn Thr Lys Tyr Arg Gly His Ile Gln Glu Ser Glu 
            180                 185                 190         


Ile Cys Thr Gln Gly Leu Val Val Pro Val Gly Ala Cys Glu Gly Asp 
        195                 200                 205             


Tyr Gly Gly Pro Leu Ala Cys Tyr Thr His Asp Ala Trp Val Leu Gln 
    210                 215                 220                 


Gly Leu Ile Ile Pro Asn Arg Val Cys Ala Arg Pro Arg Trp Pro Ala 
225                 230                 235                 240 


Ile Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile Asn Lys Val Met 
                245                 250                 255     


Gln Leu Glu Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro 
            260                 265                 270         


Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys 
        275                 280                 285             


Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val 
    290                 295                 300                 


Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
305                 310                 315                 320 


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
                325                 330                 335     


Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
            340                 345                 350         


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu 
        355                 360                 365             


Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg 
    370                 375                 380                 


Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys 
385                 390                 395                 400 


Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp 
                405                 410                 415     


Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys 
            420                 425                 430         


Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser 
        435                 440                 445             


Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser 
    450                 455                 460                 


Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser 
465                 470                 475                 480 


Phe Ser Arg Thr Pro Gly Lys 
                485         


<210>  27
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(1476)

<400>  27
atg tgg gtg acc aaa ctc ctg cca gcc ctg ctg ctg cag cat gtc ctc         48
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu           
1               5                   10                  15                

ctg cat ctc ctc ctg ctc ccc atc gcc atc ccc tat gca gag gga gtg         96
Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val           
            20                  25                  30                    

gtg gga ggc cat cct ggg aac tcc cca tgg acg gtc agc ttg cgg aat        144
Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn           
        35                  40                  45                        

cga cag ggc cag cat ttc tgt ggg ggc tcc cta gtg aag gag cag tgg        192
Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp           
    50                  55                  60                            

gta ctg act gcc cgg caa tgc atc tgg tca tgc cac gaa cct ctc aca        240
Val Leu Thr Ala Arg Gln Cys Ile Trp Ser Cys His Glu Pro Leu Thr           
65                  70                  75                  80            

gga tac gag gta tgg ttg ggt aca att aac cag aac cca cag cct gga        288
Gly Tyr Glu Val Trp Leu Gly Thr Ile Asn Gln Asn Pro Gln Pro Gly           
                85                  90                  95                

gag gca aac ctg cag agg gtc cca gtg gcc aag gca gtg tgc ggc cct        336
Glu Ala Asn Leu Gln Arg Val Pro Val Ala Lys Ala Val Cys Gly Pro           
            100                 105                 110                   

gca ggc tcc cag ctt gtt ctg ctc aag ctg gag aga cct gtg atc ctg        384
Ala Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Pro Val Ile Leu           
        115                 120                 125                       

aac cat cac gtg gcc ctg att gcc ctg cct cct gaa cag tat gtg gta        432
Asn His His Val Ala Leu Ile Ala Leu Pro Pro Glu Gln Tyr Val Val           
    130                 135                 140                           

cct cca ggg acc aag tgt gag atc gca ggc tgg ggt gaa tcc atc ggt        480
Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Ser Ile Gly           
145                 150                 155                 160           

aca agc aat aac aca gtc ctt cat gtg gcc tcg atg aat gtc atc tcc        528
Thr Ser Asn Asn Thr Val Leu His Val Ala Ser Met Asn Val Ile Ser           
                165                 170                 175               

aac cag gaa tgt aac acg aag tac cga gga cac ata caa gag agt gag        576
Asn Gln Glu Cys Asn Thr Lys Tyr Arg Gly His Ile Gln Glu Ser Glu           
            180                 185                 190                   

ata tgc acc cag gga ctg gtg gtc cct gtg ggg gct tgt gag ggt gac        624
Ile Cys Thr Gln Gly Leu Val Val Pro Val Gly Ala Cys Glu Gly Asp           
        195                 200                 205                       

tac ggg ggc cca ctt gcc tgc tat acc cat gac gca tgg gtc cta cag        672
Tyr Gly Gly Pro Leu Ala Cys Tyr Thr His Asp Ala Trp Val Leu Gln           
    210                 215                 220                           

gga ctt atc atc ccg aac aga gtg tgt gca cgg ccc cgc tgg cca gct        720
Gly Leu Ile Ile Pro Asn Arg Val Cys Ala Arg Pro Arg Trp Pro Ala           
225                 230                 235                 240           

atc ttc aca cgg gtg tct gtg ttc gtg gac tgg att aac aag gtc atg        768
Ile Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile Asn Lys Val Met           
                245                 250                 255               

cag ctg gag ccc aga ggg ccc aca atc aag ccc tgt cct cca tgc aaa        816
Gln Leu Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys           
            260                 265                 270                   

tgc cca gca cct aac ctc ttg ggt gga cca tcc gtc ttc atc ttc cct        864
Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro           
        275                 280                 285                       

cca aag atc aag gat gta ctc atg atc tcc ctg agc ccc ata gtc aca        912
Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr           
    290                 295                 300                           

tgt gtg gtg gtg gat gtg agc gag gat gac cca gat gtc cag atc agc        960
Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser           
305                 310                 315                 320           

tgg ttt gtg aac aac gtg gaa gta cac aca gct cag aca caa acc cat       1008
Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His           
                325                 330                 335               

aga gag gat tac aac agt act cta cgc gtg gtc agt gcc ctc ccc atc       1056
Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile           
            340                 345                 350                   

cag cac cag gac tgg atg agt ggc aag gag ttc aaa tgc aag gtc aac       1104
Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn           
        355                 360                 365                       

aac aaa gac ctc cca gcg ccc atc gag aga acc atc tca aaa ccc aaa       1152
Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys           
    370                 375                 380                           

ggg tca gta aga gct cca cag gta tat gtc ttg cct cca cca gaa gaa       1200
Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu           
385                 390                 395                 400           

gag atg act aag aaa cag gtc act ctg acc tgc atg gtc aca gac ttc       1248
Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe           
                405                 410                 415               

atg cct gaa gac att tac gtg gag tgg acc aac aac ggg aaa aca gag       1296
Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu           
            420                 425                 430                   

cta aac tac aag aac act gaa cca gtc ctg gac tct gat ggt tct tac       1344
Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr           
        435                 440                 445                       

ttc atg tac agc aag ctg aga gtg gaa aag aag aac tgg gtg gaa aga       1392
Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg           
    450                 455                 460                           

aat agc tac tcc tgt tca gtg gtc cac gag ggt ctg cac aat cac cac       1440
Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His           
465                 470                 475                 480           

acg act aag agc ttc tcc cgg act ccg ggt aaa tga                       1476
Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys                               
                485                 490                                   


<210>  28
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val 
            20                  25                  30          


Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn 
        35                  40                  45              


Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp 
    50                  55                  60                  


Val Leu Thr Ala Arg Gln Cys Ile Trp Ser Cys His Glu Pro Leu Thr 
65                  70                  75                  80  


Gly Tyr Glu Val Trp Leu Gly Thr Ile Asn Gln Asn Pro Gln Pro Gly 
                85                  90                  95      


Glu Ala Asn Leu Gln Arg Val Pro Val Ala Lys Ala Val Cys Gly Pro 
            100                 105                 110         


Ala Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Pro Val Ile Leu 
        115                 120                 125             


Asn His His Val Ala Leu Ile Ala Leu Pro Pro Glu Gln Tyr Val Val 
    130                 135                 140                 


Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Ser Ile Gly 
145                 150                 155                 160 


Thr Ser Asn Asn Thr Val Leu His Val Ala Ser Met Asn Val Ile Ser 
                165                 170                 175     


Asn Gln Glu Cys Asn Thr Lys Tyr Arg Gly His Ile Gln Glu Ser Glu 
            180                 185                 190         


Ile Cys Thr Gln Gly Leu Val Val Pro Val Gly Ala Cys Glu Gly Asp 
        195                 200                 205             


Tyr Gly Gly Pro Leu Ala Cys Tyr Thr His Asp Ala Trp Val Leu Gln 
    210                 215                 220                 


Gly Leu Ile Ile Pro Asn Arg Val Cys Ala Arg Pro Arg Trp Pro Ala 
225                 230                 235                 240 


Ile Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile Asn Lys Val Met 
                245                 250                 255     


Gln Leu Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys 
            260                 265                 270         


Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
        275                 280                 285             


Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser 
305                 310                 315                 320 


Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His 
                325                 330                 335     


Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile 
            340                 345                 350         


Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn 
        355                 360                 365             


Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys 
    370                 375                 380                 


Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu 
385                 390                 395                 400 


Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe 
                405                 410                 415     


Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu 
            420                 425                 430         


Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr 
        435                 440                 445             


Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg 
    450                 455                 460                 


Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His 
465                 470                 475                 480 


Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                485                 490     


<210>  29
<211>  1488
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(1488)

<400>  29
atg tgg gtg acc aaa ctc ctg cca gcc ctg ctg ctg cag cat gtc ctc         48
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu           
1               5                   10                  15                

ctg cat ctc ctc ctg ctc ccc atc gcc atc ccc tat gca gag gga gtg         96
Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val           
            20                  25                  30                    

gtg gga ggc cat cct ggg aac tcc cca tgg acg gtc agc ttg cgg aat        144
Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn           
        35                  40                  45                        

cga cag ggc cag cat ttc tgt ggg ggc tcc cta gtg aag gag cag tgg        192
Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp           
    50                  55                  60                            

gta ctg act gcc cgg caa tgc atc tgg tca tgc cac gaa cct ctc aca        240
Val Leu Thr Ala Arg Gln Cys Ile Trp Ser Cys His Glu Pro Leu Thr           
65                  70                  75                  80            

gga tac gag gta tgg ttg ggt aca att aac cag aac cca cag cct gga        288
Gly Tyr Glu Val Trp Leu Gly Thr Ile Asn Gln Asn Pro Gln Pro Gly           
                85                  90                  95                

gag gca aac ctg cag agg gtc cca gtg gcc aag gca gtg tgc ggc cct        336
Glu Ala Asn Leu Gln Arg Val Pro Val Ala Lys Ala Val Cys Gly Pro           
            100                 105                 110                   

gca ggc tcc cag ctt gtt ctg ctc aag ctg gag aga cct gtg atc ctg        384
Ala Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Pro Val Ile Leu           
        115                 120                 125                       

aac cat cac gtg gcc ctg att gcc ctg cct cct gaa cag tat gtg gta        432
Asn His His Val Ala Leu Ile Ala Leu Pro Pro Glu Gln Tyr Val Val           
    130                 135                 140                           

cct cca ggg acc aag tgt gag atc gca ggc tgg ggt gaa tcc atc ggt        480
Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Ser Ile Gly           
145                 150                 155                 160           

aca agc aat aac aca gtc ctt cat gtg gcc tcg atg aat gtc atc tcc        528
Thr Ser Asn Asn Thr Val Leu His Val Ala Ser Met Asn Val Ile Ser           
                165                 170                 175               

aac cag gaa tgt aac acg aag tac cga gga cac ata caa gag agt gag        576
Asn Gln Glu Cys Asn Thr Lys Tyr Arg Gly His Ile Gln Glu Ser Glu           
            180                 185                 190                   

ata tgc acc cag gga ctg gtg gtc cct gtg ggg gct tgt gag ggt gac        624
Ile Cys Thr Gln Gly Leu Val Val Pro Val Gly Ala Cys Glu Gly Asp           
        195                 200                 205                       

tac ggg ggc cca ctt gcc tgc tat acc cat gac gca tgg gtc cta cag        672
Tyr Gly Gly Pro Leu Ala Cys Tyr Thr His Asp Ala Trp Val Leu Gln           
    210                 215                 220                           

gga ctt atc atc ccg aac aga gtg tgt gca cgg ccc cgc tgg cca gct        720
Gly Leu Ile Ile Pro Asn Arg Val Cys Ala Arg Pro Arg Trp Pro Ala           
225                 230                 235                 240           

atc ttc aca cgg gtg tct gtg ttc gtg gac tgg att aac aag gtc atg        768
Ile Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile Asn Lys Val Met           
                245                 250                 255               

cag ctg gag aag aaa att gag ccc aga ggg ccc aca atc aag ccc tgt        816
Gln Leu Glu Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys           
            260                 265                 270                   

cct cca tgc aaa tgc cca gca cct aac ctc ttg ggt gga cca tcc gtc        864
Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val           
        275                 280                 285                       

ttc atc ttc cct cca aag atc aag gat gta ctc atg atc tcc ctg agc        912
Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser           
    290                 295                 300                           

ccc ata gtc aca tgt gtg gtg gtg gat gtg agc gag gat gac cca gat        960
Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp           
305                 310                 315                 320           

gtc cag atc agc tgg ttt gtg aac aac gtg gaa gta cac aca gct cag       1008
Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln           
                325                 330                 335               

aca caa acc cat aga gag gat tac aac agt act cta cgc gtg gtc agt       1056
Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser           
            340                 345                 350                   

gcc ctc ccc atc cag cac cag gac tgg atg agt ggc aag gag ttc aaa       1104
Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys           
        355                 360                 365                       

tgc aag gtc aac aac aaa gac ctc cca gcg ccc atc gag aga acc atc       1152
Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile           
    370                 375                 380                           

tca aaa ccc aaa ggg tca gta aga gct cca cag gta tat gtc ttg cct       1200
Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro           
385                 390                 395                 400           

cca cca gaa gaa gag atg act aag aaa cag gtc act ctg acc tgc atg       1248
Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met           
                405                 410                 415               

gtc aca gac ttc atg cct gaa gac att tac gtg gag tgg acc aac aac       1296
Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn           
            420                 425                 430                   

ggg aaa aca gag cta aac tac aag aac act gaa cca gtc ctg gac tct       1344
Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser           
        435                 440                 445                       

gat ggt tct tac ttc atg tac agc aag ctg aga gtg gaa aag aag aac       1392
Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn           
    450                 455                 460                           

tgg gtg gaa aga aat agc tac tcc tgt tca gtg gtc cac gag ggt ctg       1440
Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu           
465                 470                 475                 480           

cac aat cac cac acg act aag agc ttc tcc cgg act ccg ggt aaa tga       1488
His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys               
                485                 490                 495               


<210>  30
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val 
            20                  25                  30          


Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn 
        35                  40                  45              


Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp 
    50                  55                  60                  


Val Leu Thr Ala Arg Gln Cys Ile Trp Ser Cys His Glu Pro Leu Thr 
65                  70                  75                  80  


Gly Tyr Glu Val Trp Leu Gly Thr Ile Asn Gln Asn Pro Gln Pro Gly 
                85                  90                  95      


Glu Ala Asn Leu Gln Arg Val Pro Val Ala Lys Ala Val Cys Gly Pro 
            100                 105                 110         


Ala Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Pro Val Ile Leu 
        115                 120                 125             


Asn His His Val Ala Leu Ile Ala Leu Pro Pro Glu Gln Tyr Val Val 
    130                 135                 140                 


Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Ser Ile Gly 
145                 150                 155                 160 


Thr Ser Asn Asn Thr Val Leu His Val Ala Ser Met Asn Val Ile Ser 
                165                 170                 175     


Asn Gln Glu Cys Asn Thr Lys Tyr Arg Gly His Ile Gln Glu Ser Glu 
            180                 185                 190         


Ile Cys Thr Gln Gly Leu Val Val Pro Val Gly Ala Cys Glu Gly Asp 
        195                 200                 205             


Tyr Gly Gly Pro Leu Ala Cys Tyr Thr His Asp Ala Trp Val Leu Gln 
    210                 215                 220                 


Gly Leu Ile Ile Pro Asn Arg Val Cys Ala Arg Pro Arg Trp Pro Ala 
225                 230                 235                 240 


Ile Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile Asn Lys Val Met 
                245                 250                 255     


Gln Leu Glu Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys 
            260                 265                 270         


Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val 
        275                 280                 285             


Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser 
    290                 295                 300                 


Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
305                 310                 315                 320 


Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
                325                 330                 335     


Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser 
            340                 345                 350         


Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
        355                 360                 365             


Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile 
    370                 375                 380                 


Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro 
385                 390                 395                 400 


Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met 
                405                 410                 415     


Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn 
            420                 425                 430         


Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser 
        435                 440                 445             


Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn 
    450                 455                 460                 


Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu 
465                 470                 475                 480 


His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                485                 490                 495 


<210>  31
<211>  1500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(1500)

<400>  31
atg tgg gtg acc aaa ctc ctg cca gcc ctg ctg ctg cag cat gtc ctc         48
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu           
1               5                   10                  15                

ctg cat ctc ctc ctg ctc ccc atc gcc atc ccc tat gca gag gga gtg         96
Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val           
            20                  25                  30                    

gtg gga ggc cat cct ggg aac tcc cca tgg acg gtc agc ttg cgg aat        144
Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn           
        35                  40                  45                        

cga cag ggc cag cat ttc tgt ggg ggc tcc cta gtg aag gag cag tgg        192
Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp           
    50                  55                  60                            

gta ctg act gcc cgg caa tgc atc tgg tca tgc cac gaa cct ctc aca        240
Val Leu Thr Ala Arg Gln Cys Ile Trp Ser Cys His Glu Pro Leu Thr           
65                  70                  75                  80            

gga tac gag gta tgg ttg ggt aca att aac cag aac cca cag cct gga        288
Gly Tyr Glu Val Trp Leu Gly Thr Ile Asn Gln Asn Pro Gln Pro Gly           
                85                  90                  95                

gag gca aac ctg cag agg gtc cca gtg gcc aag gca gtg tgc ggc cct        336
Glu Ala Asn Leu Gln Arg Val Pro Val Ala Lys Ala Val Cys Gly Pro           
            100                 105                 110                   

gca ggc tcc cag ctt gtt ctg ctc aag ctg gag aga cct gtg atc ctg        384
Ala Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Pro Val Ile Leu           
        115                 120                 125                       

aac cat cac gtg gcc ctg att gcc ctg cct cct gaa cag tat gtg gta        432
Asn His His Val Ala Leu Ile Ala Leu Pro Pro Glu Gln Tyr Val Val           
    130                 135                 140                           

cct cca ggg acc aag tgt gag atc gca ggc tgg ggt gaa tcc atc ggt        480
Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Ser Ile Gly           
145                 150                 155                 160           

aca agc aat aac aca gtc ctt cat gtg gcc tcg atg aat gtc atc tcc        528
Thr Ser Asn Asn Thr Val Leu His Val Ala Ser Met Asn Val Ile Ser           
                165                 170                 175               

aac cag gaa tgt aac acg aag tac cga gga cac ata caa gag agt gag        576
Asn Gln Glu Cys Asn Thr Lys Tyr Arg Gly His Ile Gln Glu Ser Glu           
            180                 185                 190                   

ata tgc acc cag gga ctg gtg gtc cct gtg ggg gct tgt gag ggt gac        624
Ile Cys Thr Gln Gly Leu Val Val Pro Val Gly Ala Cys Glu Gly Asp           
        195                 200                 205                       

tac ggg ggc cca ctt gcc tgc tat acc cat gac gca tgg gtc cta cag        672
Tyr Gly Gly Pro Leu Ala Cys Tyr Thr His Asp Ala Trp Val Leu Gln           
    210                 215                 220                           

gga ctt atc atc ccg aac aga gtg tgt gca cgg ccc cgc tgg cca gct        720
Gly Leu Ile Ile Pro Asn Arg Val Cys Ala Arg Pro Arg Trp Pro Ala           
225                 230                 235                 240           

atc ttc aca cgg gtg tct gtg ttc gtg gac tgg att aac aag gtc atg        768
Ile Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile Asn Lys Val Met           
                245                 250                 255               

cag ctg gag cag gtc acc gac aag aaa att gag ccc aga ggg ccc aca        816
Gln Leu Glu Gln Val Thr Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr           
            260                 265                 270                   

atc aag ccc tgt cct cca tgc aaa tgc cca gca cct aac ctc ttg ggt        864
Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly           
        275                 280                 285                       

gga cca tcc gtc ttc atc ttc cct cca aag atc aag gat gta ctc atg        912
Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met           
    290                 295                 300                           

atc tcc ctg agc ccc ata gtc aca tgt gtg gtg gtg gat gtg agc gag        960
Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu           
305                 310                 315                 320           

gat gac cca gat gtc cag atc agc tgg ttt gtg aac aac gtg gaa gta       1008
Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val           
                325                 330                 335               

cac aca gct cag aca caa acc cat aga gag gat tac aac agt act cta       1056
His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu           
            340                 345                 350                   

cgc gtg gtc agt gcc ctc ccc atc cag cac cag gac tgg atg agt ggc       1104
Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly           
        355                 360                 365                       

aag gag ttc aaa tgc aag gtc aac aac aaa gac ctc cca gcg ccc atc       1152
Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile           
    370                 375                 380                           

gag aga acc atc tca aaa ccc aaa ggg tca gta aga gct cca cag gta       1200
Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val           
385                 390                 395                 400           

tat gtc ttg cct cca cca gaa gaa gag atg act aag aaa cag gtc act       1248
Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr           
                405                 410                 415               

ctg acc tgc atg gtc aca gac ttc atg cct gaa gac att tac gtg gag       1296
Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu           
            420                 425                 430                   

tgg acc aac aac ggg aaa aca gag cta aac tac aag aac act gaa cca       1344
Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro           
        435                 440                 445                       

gtc ctg gac tct gat ggt tct tac ttc atg tac agc aag ctg aga gtg       1392
Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val           
    450                 455                 460                           

gaa aag aag aac tgg gtg gaa aga aat agc tac tcc tgt tca gtg gtc       1440
Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val           
465                 470                 475                 480           

cac gag ggt ctg cac aat cac cac acg act aag agc ttc tcc cgg act       1488
His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr           
                485                 490                 495               

ccg ggt aaa tga                                                       1500
Pro Gly Lys                                                               
                                                                          


<210>  32
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val 
            20                  25                  30          


Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn 
        35                  40                  45              


Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp 
    50                  55                  60                  


Val Leu Thr Ala Arg Gln Cys Ile Trp Ser Cys His Glu Pro Leu Thr 
65                  70                  75                  80  


Gly Tyr Glu Val Trp Leu Gly Thr Ile Asn Gln Asn Pro Gln Pro Gly 
                85                  90                  95      


Glu Ala Asn Leu Gln Arg Val Pro Val Ala Lys Ala Val Cys Gly Pro 
            100                 105                 110         


Ala Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Pro Val Ile Leu 
        115                 120                 125             


Asn His His Val Ala Leu Ile Ala Leu Pro Pro Glu Gln Tyr Val Val 
    130                 135                 140                 


Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Ser Ile Gly 
145                 150                 155                 160 


Thr Ser Asn Asn Thr Val Leu His Val Ala Ser Met Asn Val Ile Ser 
                165                 170                 175     


Asn Gln Glu Cys Asn Thr Lys Tyr Arg Gly His Ile Gln Glu Ser Glu 
            180                 185                 190         


Ile Cys Thr Gln Gly Leu Val Val Pro Val Gly Ala Cys Glu Gly Asp 
        195                 200                 205             


Tyr Gly Gly Pro Leu Ala Cys Tyr Thr His Asp Ala Trp Val Leu Gln 
    210                 215                 220                 


Gly Leu Ile Ile Pro Asn Arg Val Cys Ala Arg Pro Arg Trp Pro Ala 
225                 230                 235                 240 


Ile Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile Asn Lys Val Met 
                245                 250                 255     


Gln Leu Glu Gln Val Thr Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr 
            260                 265                 270         


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
    290                 295                 300                 


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
305                 310                 315                 320 


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
                325                 330                 335     


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
            340                 345                 350         


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
        355                 360                 365             


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
385                 390                 395                 400 


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
                405                 410                 415     


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
            420                 425                 430         


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
    450                 455                 460                 


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
465                 470                 475                 480 


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
                485                 490                 495     


Pro Gly Lys 
            


<210>  33
<211>  1464
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(1464)

<400>  33
atg tgg gtg acc aaa ctc ctg cca gcc ctg ctg ctg cag cat gtc ctc         48
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu           
1               5                   10                  15                

ctg cat ctc ctc ctg ctc ccc atc gcc atc ccc tat gca gag gga gtg         96
Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val           
            20                  25                  30                    

gtg gga ggc cat cct ggg aac tcc cca tgg acg gtc agc ttg cgg aat        144
Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn           
        35                  40                  45                        

cga cag ggc cag cat ttc tgt ggg ggc tcc cta gtg aag gag cag tgg        192
Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp           
    50                  55                  60                            

gta ctg act gcc cgg caa tgc atc tgg tca tgc cac gaa cct ctc aca        240
Val Leu Thr Ala Arg Gln Cys Ile Trp Ser Cys His Glu Pro Leu Thr           
65                  70                  75                  80            

gga tac gag gta tgg ttg ggt aca att aac cag aac cca cag cct gga        288
Gly Tyr Glu Val Trp Leu Gly Thr Ile Asn Gln Asn Pro Gln Pro Gly           
                85                  90                  95                

gag gca aac ctg cag agg gtc cca gtg gcc aag gca gtg tgc ggc cct        336
Glu Ala Asn Leu Gln Arg Val Pro Val Ala Lys Ala Val Cys Gly Pro           
            100                 105                 110                   

gca ggc tcc cag ctt gtt ctg ctc aag ctg gag aga cct gtg atc ctg        384
Ala Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Pro Val Ile Leu           
        115                 120                 125                       

aac cat cac gtg gcc ctg att gcc ctg cct cct gaa cag tat gtg gta        432
Asn His His Val Ala Leu Ile Ala Leu Pro Pro Glu Gln Tyr Val Val           
    130                 135                 140                           

cct cca ggg acc aag tgt gag atc gca ggc tgg ggt gaa tcc atc ggt        480
Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Ser Ile Gly           
145                 150                 155                 160           

aca agc aat aac aca gtc ctt cat gtg gcc tcg atg aat gtc atc tcc        528
Thr Ser Asn Asn Thr Val Leu His Val Ala Ser Met Asn Val Ile Ser           
                165                 170                 175               

aac cag gaa tgt aac acg aag tac cga gga cac ata caa gag agt gag        576
Asn Gln Glu Cys Asn Thr Lys Tyr Arg Gly His Ile Gln Glu Ser Glu           
            180                 185                 190                   

ata tgc acc cag gga ctg gtg gtc cct gtg ggg gct tgt gag ggt gac        624
Ile Cys Thr Gln Gly Leu Val Val Pro Val Gly Ala Cys Glu Gly Asp           
        195                 200                 205                       

tac ggg ggc cca ctt gcc tgc tat acc cat gac gca tgg gtc cta cag        672
Tyr Gly Gly Pro Leu Ala Cys Tyr Thr His Asp Ala Trp Val Leu Gln           
    210                 215                 220                           

gga ctt atc atc ccg aac aga gtg tgt gca cgg ccc cgc tgg cca gct        720
Gly Leu Ile Ile Pro Asn Arg Val Cys Ala Arg Pro Arg Trp Pro Ala           
225                 230                 235                 240           

atc ttc aca cgg gtg tct gtg ttc gtg gac tgg att aac aag gtc atg        768
Ile Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile Asn Lys Val Met           
                245                 250                 255               

cag ctg gag aca atc aag ccc tgt cct cca tgc aaa tgc cca gca cct        816
Gln Leu Glu Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro           
            260                 265                 270                   

aac ctc ttg ggt gga cca tcc gtc ttc atc ttc cct cca aag atc aag        864
Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys           
        275                 280                 285                       

gat gta ctc atg atc tcc ctg agc ccc ata gtc aca tgt gtg gtg gtg        912
Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val           
    290                 295                 300                           

gct gtg agc gag gat gac cca gat gtc cag atc agc tgg ttt gtg aac        960
Ala Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn           
305                 310                 315                 320           

aac gtg gaa gta cac aca gct cag aca caa acc cat aga gag gat tac       1008
Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr           
                325                 330                 335               

gcc agt act cta cgc gtg gtc agt gcc ctc ccc atc cag cac cag gac       1056
Ala Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp           
            340                 345                 350                   

tgg atg agt ggc aag gag ttc aaa tgc aag gtc aac aac aaa gac ctc       1104
Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu           
        355                 360                 365                       

cca gcg ccc atc gag aga acc atc tca aaa ccc aaa ggg tca gta aga       1152
Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg           
    370                 375                 380                           

gct cca cag gta tat gtc ttg cct cca cca gaa gaa gag atg act aag       1200
Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys           
385                 390                 395                 400           

aaa cag gtc act ctg acc tgc atg gtc aca gac ttc atg cct gaa gac       1248
Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp           
                405                 410                 415               

att tac gtg gag tgg acc aac aac ggg aaa aca gag cta aac tac aag       1296
Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys           
            420                 425                 430                   

aac act gaa cca gtc ctg gac tct gat ggt tct tac ttc atg tac agc       1344
Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser           
        435                 440                 445                       

aag ctg aga gtg gaa aag aag aac tgg gtg gaa aga aat agc tac tcc       1392
Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser           
    450                 455                 460                           

tgt tca gtg gtc cac gag ggt ctg cac aat cac cac acg act aag agc       1440
Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser           
465                 470                 475                 480           

ttc tcc cgg act ccg ggt aaa tga                                       1464
Phe Ser Arg Thr Pro Gly Lys                                               
                485                                                       


<210>  34
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val 
            20                  25                  30          


Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn 
        35                  40                  45              


Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp 
    50                  55                  60                  


Val Leu Thr Ala Arg Gln Cys Ile Trp Ser Cys His Glu Pro Leu Thr 
65                  70                  75                  80  


Gly Tyr Glu Val Trp Leu Gly Thr Ile Asn Gln Asn Pro Gln Pro Gly 
                85                  90                  95      


Glu Ala Asn Leu Gln Arg Val Pro Val Ala Lys Ala Val Cys Gly Pro 
            100                 105                 110         


Ala Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Pro Val Ile Leu 
        115                 120                 125             


Asn His His Val Ala Leu Ile Ala Leu Pro Pro Glu Gln Tyr Val Val 
    130                 135                 140                 


Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Ser Ile Gly 
145                 150                 155                 160 


Thr Ser Asn Asn Thr Val Leu His Val Ala Ser Met Asn Val Ile Ser 
                165                 170                 175     


Asn Gln Glu Cys Asn Thr Lys Tyr Arg Gly His Ile Gln Glu Ser Glu 
            180                 185                 190         


Ile Cys Thr Gln Gly Leu Val Val Pro Val Gly Ala Cys Glu Gly Asp 
        195                 200                 205             


Tyr Gly Gly Pro Leu Ala Cys Tyr Thr His Asp Ala Trp Val Leu Gln 
    210                 215                 220                 


Gly Leu Ile Ile Pro Asn Arg Val Cys Ala Arg Pro Arg Trp Pro Ala 
225                 230                 235                 240 


Ile Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile Asn Lys Val Met 
                245                 250                 255     


Gln Leu Glu Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro 
            260                 265                 270         


Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys 
        275                 280                 285             


Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val 
    290                 295                 300                 


Ala Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
305                 310                 315                 320 


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
                325                 330                 335     


Ala Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
            340                 345                 350         


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu 
        355                 360                 365             


Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg 
    370                 375                 380                 


Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys 
385                 390                 395                 400 


Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp 
                405                 410                 415     


Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys 
            420                 425                 430         


Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser 
        435                 440                 445             


Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser 
    450                 455                 460                 


Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser 
465                 470                 475                 480 


Phe Ser Arg Thr Pro Gly Lys 
                485         


<210>  35
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(1476)

<400>  35
atg tgg gtg acc aaa ctc ctg cca gcc ctg ctg ctg cag cat gtc ctc         48
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu           
1               5                   10                  15                

ctg cat ctc ctc ctg ctc ccc atc gcc atc ccc tat gca gag gga gtg         96
Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val           
            20                  25                  30                    

gtg gga ggc cat cct ggg aac tcc cca tgg acg gtc agc ttg cgg aat        144
Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn           
        35                  40                  45                        

cga cag ggc cag cat ttc tgt ggg ggc tcc cta gtg aag gag cag tgg        192
Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp           
    50                  55                  60                            

gta ctg act gcc cgg caa tgc atc tgg tca tgc cac gaa cct ctc aca        240
Val Leu Thr Ala Arg Gln Cys Ile Trp Ser Cys His Glu Pro Leu Thr           
65                  70                  75                  80            

gga tac gag gta tgg ttg ggt aca att aac cag aac cca cag cct gga        288
Gly Tyr Glu Val Trp Leu Gly Thr Ile Asn Gln Asn Pro Gln Pro Gly           
                85                  90                  95                

gag gca aac ctg cag agg gtc cca gtg gcc aag gca gtg tgc ggc cct        336
Glu Ala Asn Leu Gln Arg Val Pro Val Ala Lys Ala Val Cys Gly Pro           
            100                 105                 110                   

gca ggc tcc cag ctt gtt ctg ctc aag ctg gag aga cct gtg atc ctg        384
Ala Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Pro Val Ile Leu           
        115                 120                 125                       

aac cat cac gtg gcc ctg att gcc ctg cct cct gaa cag tat gtg gta        432
Asn His His Val Ala Leu Ile Ala Leu Pro Pro Glu Gln Tyr Val Val           
    130                 135                 140                           

cct cca ggg acc aag tgt gag atc gca ggc tgg ggt gaa tcc atc ggt        480
Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Ser Ile Gly           
145                 150                 155                 160           

aca agc aat aac aca gtc ctt cat gtg gcc tcg atg aat gtc atc tcc        528
Thr Ser Asn Asn Thr Val Leu His Val Ala Ser Met Asn Val Ile Ser           
                165                 170                 175               

aac cag gaa tgt aac acg aag tac cga gga cac ata caa gag agt gag        576
Asn Gln Glu Cys Asn Thr Lys Tyr Arg Gly His Ile Gln Glu Ser Glu           
            180                 185                 190                   

ata tgc acc cag gga ctg gtg gtc cct gtg ggg gct tgt gag ggt gac        624
Ile Cys Thr Gln Gly Leu Val Val Pro Val Gly Ala Cys Glu Gly Asp           
        195                 200                 205                       

tac ggg ggc cca ctt gcc tgc tat acc cat gac gca tgg gtc cta cag        672
Tyr Gly Gly Pro Leu Ala Cys Tyr Thr His Asp Ala Trp Val Leu Gln           
    210                 215                 220                           

gga ctt atc atc ccg aac aga gtg tgt gca cgg ccc cgc tgg cca gct        720
Gly Leu Ile Ile Pro Asn Arg Val Cys Ala Arg Pro Arg Trp Pro Ala           
225                 230                 235                 240           

atc ttc aca cgg gtg tct gtg ttc gtg gac tgg att aac aag gtc atg        768
Ile Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile Asn Lys Val Met           
                245                 250                 255               

cag ctg gag ccc aga gga ccc aca atc aag ccc tgt cct cca tgc aaa        816
Gln Leu Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys           
            260                 265                 270                   

tgc cca gca cct aac ctc ttg ggt gga cca tcc gtc ttc atc ttc cct        864
Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro           
        275                 280                 285                       

cca aag atc aag gat gta ctc atg atc tcc ctg agc ccc ata gtc aca        912
Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr           
    290                 295                 300                           

tgt gtg gtg gtg gct gtg agc gag gat gac cca gat gtc cag atc agc        960
Cys Val Val Val Ala Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser           
305                 310                 315                 320           

tgg ttt gtg aac aac gtg gaa gta cac aca gct cag aca caa acc cat       1008
Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His           
                325                 330                 335               

aga gag gat tac gcc agt act cta cgc gtg gtc agt gcc ctc ccc atc       1056
Arg Glu Asp Tyr Ala Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile           
            340                 345                 350                   

cag cac cag gac tgg atg agt ggc aag gag ttc aaa tgc aag gtc aac       1104
Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn           
        355                 360                 365                       

aac aaa gac ctc cca gcg ccc atc gag aga acc atc tca aaa ccc aaa       1152
Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys           
    370                 375                 380                           

ggg tca gta aga gct cca cag gta tat gtc ttg cct cca cca gaa gaa       1200
Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu           
385                 390                 395                 400           

gag atg act aag aaa cag gtc act ctg acc tgc atg gtc aca gac ttc       1248
Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe           
                405                 410                 415               

atg cct gaa gac att tac gtg gag tgg acc aac aac ggg aaa aca gag       1296
Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu           
            420                 425                 430                   

cta aac tac aag aac act gaa cca gtc ctg gac tct gat ggt tct tac       1344
Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr           
        435                 440                 445                       

ttc atg tac agc aag ctg aga gtg gaa aag aag aac tgg gtg gaa aga       1392
Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg           
    450                 455                 460                           

aat agc tac tcc tgt tca gtg gtc cac gag ggt ctg cac aat cac cac       1440
Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His           
465                 470                 475                 480           

acg act aag agc ttc tcc cgg act ccg ggt aaa tga                       1476
Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys                               
                485                 490                                   


<210>  36
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val 
            20                  25                  30          


Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn 
        35                  40                  45              


Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp 
    50                  55                  60                  


Val Leu Thr Ala Arg Gln Cys Ile Trp Ser Cys His Glu Pro Leu Thr 
65                  70                  75                  80  


Gly Tyr Glu Val Trp Leu Gly Thr Ile Asn Gln Asn Pro Gln Pro Gly 
                85                  90                  95      


Glu Ala Asn Leu Gln Arg Val Pro Val Ala Lys Ala Val Cys Gly Pro 
            100                 105                 110         


Ala Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Pro Val Ile Leu 
        115                 120                 125             


Asn His His Val Ala Leu Ile Ala Leu Pro Pro Glu Gln Tyr Val Val 
    130                 135                 140                 


Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Ser Ile Gly 
145                 150                 155                 160 


Thr Ser Asn Asn Thr Val Leu His Val Ala Ser Met Asn Val Ile Ser 
                165                 170                 175     


Asn Gln Glu Cys Asn Thr Lys Tyr Arg Gly His Ile Gln Glu Ser Glu 
            180                 185                 190         


Ile Cys Thr Gln Gly Leu Val Val Pro Val Gly Ala Cys Glu Gly Asp 
        195                 200                 205             


Tyr Gly Gly Pro Leu Ala Cys Tyr Thr His Asp Ala Trp Val Leu Gln 
    210                 215                 220                 


Gly Leu Ile Ile Pro Asn Arg Val Cys Ala Arg Pro Arg Trp Pro Ala 
225                 230                 235                 240 


Ile Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile Asn Lys Val Met 
                245                 250                 255     


Gln Leu Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys 
            260                 265                 270         


Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
        275                 280                 285             


Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr 
    290                 295                 300                 


Cys Val Val Val Ala Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser 
305                 310                 315                 320 


Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His 
                325                 330                 335     


Arg Glu Asp Tyr Ala Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile 
            340                 345                 350         


Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn 
        355                 360                 365             


Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys 
    370                 375                 380                 


Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu 
385                 390                 395                 400 


Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe 
                405                 410                 415     


Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu 
            420                 425                 430         


Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr 
        435                 440                 445             


Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg 
    450                 455                 460                 


Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His 
465                 470                 475                 480 


Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                485                 490     


<210>  37
<211>  1488
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(1488)

<400>  37
atg tgg gtg acc aaa ctc ctg cca gcc ctg ctg ctg cag cat gtc ctc         48
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu           
1               5                   10                  15                

ctg cat ctc ctc ctg ctc ccc atc gcc atc ccc tat gca gag gga gtg         96
Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val           
            20                  25                  30                    

gtg gga ggc cat cct ggg aac tcc cca tgg acg gtc agc ttg cgg aat        144
Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn           
        35                  40                  45                        

cga cag ggc cag cat ttc tgt ggg ggc tcc cta gtg aag gag cag tgg        192
Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp           
    50                  55                  60                            

gta ctg act gcc cgg caa tgc atc tgg tca tgc cac gaa cct ctc aca        240
Val Leu Thr Ala Arg Gln Cys Ile Trp Ser Cys His Glu Pro Leu Thr           
65                  70                  75                  80            

gga tac gag gta tgg ttg ggt aca att aac cag aac cca cag cct gga        288
Gly Tyr Glu Val Trp Leu Gly Thr Ile Asn Gln Asn Pro Gln Pro Gly           
                85                  90                  95                

gag gca aac ctg cag agg gtc cca gtg gcc aag gca gtg tgc ggc cct        336
Glu Ala Asn Leu Gln Arg Val Pro Val Ala Lys Ala Val Cys Gly Pro           
            100                 105                 110                   

gca ggc tcc cag ctt gtt ctg ctc aag ctg gag aga cct gtg atc ctg        384
Ala Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Pro Val Ile Leu           
        115                 120                 125                       

aac cat cac gtg gcc ctg att gcc ctg cct cct gaa cag tat gtg gta        432
Asn His His Val Ala Leu Ile Ala Leu Pro Pro Glu Gln Tyr Val Val           
    130                 135                 140                           

cct cca ggg acc aag tgt gag atc gca ggc tgg ggt gaa tcc atc ggt        480
Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Ser Ile Gly           
145                 150                 155                 160           

aca agc aat aac aca gtc ctt cat gtg gcc tcg atg aat gtc atc tcc        528
Thr Ser Asn Asn Thr Val Leu His Val Ala Ser Met Asn Val Ile Ser           
                165                 170                 175               

aac cag gaa tgt aac acg aag tac cga gga cac ata caa gag agt gag        576
Asn Gln Glu Cys Asn Thr Lys Tyr Arg Gly His Ile Gln Glu Ser Glu           
            180                 185                 190                   

ata tgc acc cag gga ctg gtg gtc cct gtg ggg gct tgt gag ggt gac        624
Ile Cys Thr Gln Gly Leu Val Val Pro Val Gly Ala Cys Glu Gly Asp           
        195                 200                 205                       

tac ggg ggc cca ctt gcc tgc tat acc cat gac gca tgg gtc cta cag        672
Tyr Gly Gly Pro Leu Ala Cys Tyr Thr His Asp Ala Trp Val Leu Gln           
    210                 215                 220                           

gga ctt atc atc ccg aac aga gtg tgt gca cgg ccc cgc tgg cca gct        720
Gly Leu Ile Ile Pro Asn Arg Val Cys Ala Arg Pro Arg Trp Pro Ala           
225                 230                 235                 240           

atc ttc aca cgg gtg tct gtg ttc gtg gac tgg att aac aag gtc atg        768
Ile Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile Asn Lys Val Met           
                245                 250                 255               

cag ctg gag aag aaa att gag ccc aga gga ccc aca atc aag ccc tgt        816
Gln Leu Glu Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys           
            260                 265                 270                   

cct cca tgc aaa tgc cca gca cct aac ctc ttg ggt gga cca tcc gtc        864
Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val           
        275                 280                 285                       

ttc atc ttc cct cca aag atc aag gat gta ctc atg atc tcc ctg agc        912
Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser           
    290                 295                 300                           

ccc ata gtc aca tgt gtg gtg gtg gct gtg agc gag gat gac cca gat        960
Pro Ile Val Thr Cys Val Val Val Ala Val Ser Glu Asp Asp Pro Asp           
305                 310                 315                 320           

gtc cag atc agc tgg ttt gtg aac aac gtg gaa gta cac aca gct cag       1008
Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln           
                325                 330                 335               

aca caa acc cat aga gag gat tac gcc agt act cta cgc gtg gtc agt       1056
Thr Gln Thr His Arg Glu Asp Tyr Ala Ser Thr Leu Arg Val Val Ser           
            340                 345                 350                   

gcc ctc ccc atc cag cac cag gac tgg atg agt ggc aag gag ttc aaa       1104
Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys           
        355                 360                 365                       

tgc aag gtc aac aac aaa gac ctc cca gcg ccc atc gag aga acc atc       1152
Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile           
    370                 375                 380                           

tca aaa ccc aaa ggg tca gta aga gct cca cag gta tat gtc ttg cct       1200
Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro           
385                 390                 395                 400           

cca cca gaa gaa gag atg act aag aaa cag gtc act ctg acc tgc atg       1248
Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met           
                405                 410                 415               

gtc aca gac ttc atg cct gaa gac att tac gtg gag tgg acc aac aac       1296
Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn           
            420                 425                 430                   

ggg aaa aca gag cta aac tac aag aac act gaa cca gtc ctg gac tct       1344
Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser           
        435                 440                 445                       

gat ggt tct tac ttc atg tac agc aag ctg aga gtg gaa aag aag aac       1392
Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn           
    450                 455                 460                           

tgg gtg gaa aga aat agc tac tcc tgt tca gtg gtc cac gag ggt ctg       1440
Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu           
465                 470                 475                 480           

cac aat cac cac acg act aag agc ttc tcc cgg act ccg ggt aaa tga       1488
His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys               
                485                 490                 495               


<210>  38
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val 
            20                  25                  30          


Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn 
        35                  40                  45              


Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp 
    50                  55                  60                  


Val Leu Thr Ala Arg Gln Cys Ile Trp Ser Cys His Glu Pro Leu Thr 
65                  70                  75                  80  


Gly Tyr Glu Val Trp Leu Gly Thr Ile Asn Gln Asn Pro Gln Pro Gly 
                85                  90                  95      


Glu Ala Asn Leu Gln Arg Val Pro Val Ala Lys Ala Val Cys Gly Pro 
            100                 105                 110         


Ala Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Pro Val Ile Leu 
        115                 120                 125             


Asn His His Val Ala Leu Ile Ala Leu Pro Pro Glu Gln Tyr Val Val 
    130                 135                 140                 


Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Ser Ile Gly 
145                 150                 155                 160 


Thr Ser Asn Asn Thr Val Leu His Val Ala Ser Met Asn Val Ile Ser 
                165                 170                 175     


Asn Gln Glu Cys Asn Thr Lys Tyr Arg Gly His Ile Gln Glu Ser Glu 
            180                 185                 190         


Ile Cys Thr Gln Gly Leu Val Val Pro Val Gly Ala Cys Glu Gly Asp 
        195                 200                 205             


Tyr Gly Gly Pro Leu Ala Cys Tyr Thr His Asp Ala Trp Val Leu Gln 
    210                 215                 220                 


Gly Leu Ile Ile Pro Asn Arg Val Cys Ala Arg Pro Arg Trp Pro Ala 
225                 230                 235                 240 


Ile Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile Asn Lys Val Met 
                245                 250                 255     


Gln Leu Glu Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys 
            260                 265                 270         


Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val 
        275                 280                 285             


Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser 
    290                 295                 300                 


Pro Ile Val Thr Cys Val Val Val Ala Val Ser Glu Asp Asp Pro Asp 
305                 310                 315                 320 


Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
                325                 330                 335     


Thr Gln Thr His Arg Glu Asp Tyr Ala Ser Thr Leu Arg Val Val Ser 
            340                 345                 350         


Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
        355                 360                 365             


Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile 
    370                 375                 380                 


Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro 
385                 390                 395                 400 


Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met 
                405                 410                 415     


Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn 
            420                 425                 430         


Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser 
        435                 440                 445             


Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn 
    450                 455                 460                 


Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu 
465                 470                 475                 480 


His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                485                 490                 495 


<210>  39
<211>  1500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(1500)

<400>  39
atg tgg gtg acc aaa ctc ctg cca gcc ctg ctg ctg cag cat gtc ctc         48
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu           
1               5                   10                  15                

ctg cat ctc ctc ctg ctc ccc atc gcc atc ccc tat gca gag gga gtg         96
Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val           
            20                  25                  30                    

gtg gga ggc cat cct ggg aac tcc cca tgg acg gtc agc ttg cgg aat        144
Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn           
        35                  40                  45                        

cga cag ggc cag cat ttc tgt ggg ggc tcc cta gtg aag gag cag tgg        192
Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp           
    50                  55                  60                            

gta ctg act gcc cgg caa tgc atc tgg tca tgc cac gaa cct ctc aca        240
Val Leu Thr Ala Arg Gln Cys Ile Trp Ser Cys His Glu Pro Leu Thr           
65                  70                  75                  80            

gga tac gag gta tgg ttg ggt aca att aac cag aac cca cag cct gga        288
Gly Tyr Glu Val Trp Leu Gly Thr Ile Asn Gln Asn Pro Gln Pro Gly           
                85                  90                  95                

gag gca aac ctg cag agg gtc cca gtg gcc aag gca gtg tgc ggc cct        336
Glu Ala Asn Leu Gln Arg Val Pro Val Ala Lys Ala Val Cys Gly Pro           
            100                 105                 110                   

gca ggc tcc cag ctt gtt ctg ctc aag ctg gag aga cct gtg atc ctg        384
Ala Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Pro Val Ile Leu           
        115                 120                 125                       

aac cat cac gtg gcc ctg att gcc ctg cct cct gaa cag tat gtg gta        432
Asn His His Val Ala Leu Ile Ala Leu Pro Pro Glu Gln Tyr Val Val           
    130                 135                 140                           

cct cca ggg acc aag tgt gag atc gca ggc tgg ggt gaa tcc atc ggt        480
Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Ser Ile Gly           
145                 150                 155                 160           

aca agc aat aac aca gtc ctt cat gtg gcc tcg atg aat gtc atc tcc        528
Thr Ser Asn Asn Thr Val Leu His Val Ala Ser Met Asn Val Ile Ser           
                165                 170                 175               

aac cag gaa tgt aac acg aag tac cga gga cac ata caa gag agt gag        576
Asn Gln Glu Cys Asn Thr Lys Tyr Arg Gly His Ile Gln Glu Ser Glu           
            180                 185                 190                   

ata tgc acc cag gga ctg gtg gtc cct gtg ggg gct tgt gag ggt gac        624
Ile Cys Thr Gln Gly Leu Val Val Pro Val Gly Ala Cys Glu Gly Asp           
        195                 200                 205                       

tac ggg ggc cca ctt gcc tgc tat acc cat gac gca tgg gtc cta cag        672
Tyr Gly Gly Pro Leu Ala Cys Tyr Thr His Asp Ala Trp Val Leu Gln           
    210                 215                 220                           

gga ctt atc atc ccg aac aga gtg tgt gca cgg ccc cgc tgg cca gct        720
Gly Leu Ile Ile Pro Asn Arg Val Cys Ala Arg Pro Arg Trp Pro Ala           
225                 230                 235                 240           

atc ttc aca cgg gtg tct gtg ttc gtg gac tgg att aac aag gtc atg        768
Ile Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile Asn Lys Val Met           
                245                 250                 255               

cag ctg gag cag gtc acc gac aag aaa att gag ccc aga gga ccc aca        816
Gln Leu Glu Gln Val Thr Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr           
            260                 265                 270                   

atc aag ccc tgt cct cca tgc aaa tgc cca gca cct aac ctc ttg ggt        864
Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly           
        275                 280                 285                       

gga cca tcc gtc ttc atc ttc cct cca aag atc aag gat gta ctc atg        912
Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met           
    290                 295                 300                           

atc tcc ctg agc ccc ata gtc aca tgt gtg gtg gtg gct gtg agc gag        960
Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Ala Val Ser Glu           
305                 310                 315                 320           

gat gac cca gat gtc cag atc agc tgg ttt gtg aac aac gtg gaa gta       1008
Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val           
                325                 330                 335               

cac aca gct cag aca caa acc cat aga gag gat tac gcc agt act cta       1056
His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Ala Ser Thr Leu           
            340                 345                 350                   

cgc gtg gtc agt gcc ctc ccc atc cag cac cag gac tgg atg agt ggc       1104
Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly           
        355                 360                 365                       

aag gag ttc aaa tgc aag gtc aac aac aaa gac ctc cca gcg ccc atc       1152
Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile           
    370                 375                 380                           

gag aga acc atc tca aaa ccc aaa ggg tca gta aga gct cca cag gta       1200
Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val           
385                 390                 395                 400           

tat gtc ttg cct cca cca gaa gaa gag atg act aag aaa cag gtc act       1248
Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr           
                405                 410                 415               

ctg acc tgc atg gtc aca gac ttc atg cct gaa gac att tac gtg gag       1296
Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu           
            420                 425                 430                   

tgg acc aac aac ggg aaa aca gag cta aac tac aag aac act gaa cca       1344
Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro           
        435                 440                 445                       

gtc ctg gac tct gat ggt tct tac ttc atg tac agc aag ctg aga gtg       1392
Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val           
    450                 455                 460                           

gaa aag aag aac tgg gtg gaa aga aat agc tac tcc tgt tca gtg gtc       1440
Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val           
465                 470                 475                 480           

cac gag ggt ctg cac aat cac cac acg act aag agc ttc tcc cgg act       1488
His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr           
                485                 490                 495               

ccg ggt aaa tga                                                       1500
Pro Gly Lys                                                               
                                                                          


<210>  40
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Val 
            20                  25                  30          


Val Gly Gly His Pro Gly Asn Ser Pro Trp Thr Val Ser Leu Arg Asn 
        35                  40                  45              


Arg Gln Gly Gln His Phe Cys Gly Gly Ser Leu Val Lys Glu Gln Trp 
    50                  55                  60                  


Val Leu Thr Ala Arg Gln Cys Ile Trp Ser Cys His Glu Pro Leu Thr 
65                  70                  75                  80  


Gly Tyr Glu Val Trp Leu Gly Thr Ile Asn Gln Asn Pro Gln Pro Gly 
                85                  90                  95      


Glu Ala Asn Leu Gln Arg Val Pro Val Ala Lys Ala Val Cys Gly Pro 
            100                 105                 110         


Ala Gly Ser Gln Leu Val Leu Leu Lys Leu Glu Arg Pro Val Ile Leu 
        115                 120                 125             


Asn His His Val Ala Leu Ile Ala Leu Pro Pro Glu Gln Tyr Val Val 
    130                 135                 140                 


Pro Pro Gly Thr Lys Cys Glu Ile Ala Gly Trp Gly Glu Ser Ile Gly 
145                 150                 155                 160 


Thr Ser Asn Asn Thr Val Leu His Val Ala Ser Met Asn Val Ile Ser 
                165                 170                 175     


Asn Gln Glu Cys Asn Thr Lys Tyr Arg Gly His Ile Gln Glu Ser Glu 
            180                 185                 190         


Ile Cys Thr Gln Gly Leu Val Val Pro Val Gly Ala Cys Glu Gly Asp 
        195                 200                 205             


Tyr Gly Gly Pro Leu Ala Cys Tyr Thr His Asp Ala Trp Val Leu Gln 
    210                 215                 220                 


Gly Leu Ile Ile Pro Asn Arg Val Cys Ala Arg Pro Arg Trp Pro Ala 
225                 230                 235                 240 


Ile Phe Thr Arg Val Ser Val Phe Val Asp Trp Ile Asn Lys Val Met 
                245                 250                 255     


Gln Leu Glu Gln Val Thr Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr 
            260                 265                 270         


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
    290                 295                 300                 


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Ala Val Ser Glu 
305                 310                 315                 320 


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
                325                 330                 335     


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Ala Ser Thr Leu 
            340                 345                 350         


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
        355                 360                 365             


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
385                 390                 395                 400 


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
                405                 410                 415     


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
            420                 425                 430         


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
    450                 455                 460                 


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
465                 470                 475                 480 


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
                485                 490                 495     


Pro Gly Lys 
            


<210>  41
<211>  4203
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(4203)

<400>  41
atg gag ctc ctc ccg ccg ctg cct cag tcc ttc ctg ttg ctg ctg ctg         48
Met Glu Leu Leu Pro Pro Leu Pro Gln Ser Phe Leu Leu Leu Leu Leu           
1               5                   10                  15                

ttg cct gcc aag ccc gcg gcg ggc gag gac tgg cag tgc ccg cgc acc         96
Leu Pro Ala Lys Pro Ala Ala Gly Glu Asp Trp Gln Cys Pro Arg Thr           
            20                  25                  30                    

ccc tac gcg gcc tct cgc gac ttt gac gtg aag tac gtg gtg ccc agc        144
Pro Tyr Ala Ala Ser Arg Asp Phe Asp Val Lys Tyr Val Val Pro Ser           
        35                  40                  45                        

ttc tcc gcc gga ggc ctg gta cag gcc atg gtg acc tac gag ggc gac        192
Phe Ser Ala Gly Gly Leu Val Gln Ala Met Val Thr Tyr Glu Gly Asp           
    50                  55                  60                            

aga aat gag agt gct gtg ttt gta gcc ata cgc aat cgc ctg cat gtg        240
Arg Asn Glu Ser Ala Val Phe Val Ala Ile Arg Asn Arg Leu His Val           
65                  70                  75                  80            

ctt ggg cct gac ctg aag tct gtc cag agc ctg gcc acg ggc cct gct        288
Leu Gly Pro Asp Leu Lys Ser Val Gln Ser Leu Ala Thr Gly Pro Ala           
                85                  90                  95                

gga gac cct ggc tgc cag acg tgt gca gcc tgt ggc cca gga ccc cac        336
Gly Asp Pro Gly Cys Gln Thr Cys Ala Ala Cys Gly Pro Gly Pro His           
            100                 105                 110                   

ggc cct ccc ggt gac aca gac aca aag gtg ctg gtg ctg gat ccc gcg        384
Gly Pro Pro Gly Asp Thr Asp Thr Lys Val Leu Val Leu Asp Pro Ala           
        115                 120                 125                       

ctg cct gcg ctg gtc agt tgt ggc tcc agc ctg cag ggc cgc tgc ttc        432
Leu Pro Ala Leu Val Ser Cys Gly Ser Ser Leu Gln Gly Arg Cys Phe           
    130                 135                 140                           

ctg cat gac cta gag ccc caa ggg aca gcc gtg cat ctg gca gcg cca        480
Leu His Asp Leu Glu Pro Gln Gly Thr Ala Val His Leu Ala Ala Pro           
145                 150                 155                 160           

gcc tgc ctc ttc tca gcc cac cat aac cgg ccc gat gac tgc ccc gac        528
Ala Cys Leu Phe Ser Ala His His Asn Arg Pro Asp Asp Cys Pro Asp           
                165                 170                 175               

tgt gtg gcc agc cca ttg ggc acc cgt gta act gtg gtt gag caa ggc        576
Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln Gly           
            180                 185                 190                   

cag gcc tcc tat ttc tac gtg gca tcc tca ctg gac gca gcc gtg gct        624
Gln Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Ala Ala Val Ala           
        195                 200                 205                       

gcc agc ttc agc cca cgc tca gtg tct atc agg cgt ctc aag gct gac        672
Ala Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ala Asp           
    210                 215                 220                           

gcc tcg gga ttc gca ccg ggc ttt gtg gcg ttg tca gtg ctg ccc aag        720
Ala Ser Gly Phe Ala Pro Gly Phe Val Ala Leu Ser Val Leu Pro Lys           
225                 230                 235                 240           

cat ctt gtc tcc tac agt att gaa tac gtg cac agc ttc cac acg gga        768
His Leu Val Ser Tyr Ser Ile Glu Tyr Val His Ser Phe His Thr Gly           
                245                 250                 255               

gcc ttc gta tac ttc ctg act gta cag ccg gcc agc gtg aca gat gat        816
Ala Phe Val Tyr Phe Leu Thr Val Gln Pro Ala Ser Val Thr Asp Asp           
            260                 265                 270                   

cct agt gcc ctg cac aca cgc ctg gca cgg ctt agc gcc act gag cca        864
Pro Ser Ala Leu His Thr Arg Leu Ala Arg Leu Ser Ala Thr Glu Pro           
        275                 280                 285                       

gag ttg ggt gac tat cgg gag ctg gtc ctc gac tgc aga ttt gct cca        912
Glu Leu Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys Arg Phe Ala Pro           
    290                 295                 300                           

aaa cgc agg cgc cgg ggg gcc cca gaa ggc gga cag ccc tac cct gtg        960
Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Gly Gln Pro Tyr Pro Val           
305                 310                 315                 320           

ctg cgg gtg gcc cac tcc gct cca gtg ggt gcc caa ctt gcc act gag       1008
Leu Arg Val Ala His Ser Ala Pro Val Gly Ala Gln Leu Ala Thr Glu           
                325                 330                 335               

ctg agc atc gcc gag ggc cag gaa gta cta ttt ggg gtc ttt gtg act       1056
Leu Ser Ile Ala Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val Thr           
            340                 345                 350                   

ggc aag gat ggt ggt cct ggc gtg ggc ccc aac tct gtc gtc tgt gcc       1104
Gly Lys Asp Gly Gly Pro Gly Val Gly Pro Asn Ser Val Val Cys Ala           
        355                 360                 365                       

ttc ccc att gac ctg ctg gac aca cta att gat gag ggt gtg gag cgc       1152
Phe Pro Ile Asp Leu Leu Asp Thr Leu Ile Asp Glu Gly Val Glu Arg           
    370                 375                 380                           

tgt tgt gaa tcc cca gtc cat cca ggc ctc cgg cga ggc ctc gac ttc       1200
Cys Cys Glu Ser Pro Val His Pro Gly Leu Arg Arg Gly Leu Asp Phe           
385                 390                 395                 400           

ttc cag tcg ccc agt ttt tgc ccc aac ccg cct ggc ctg gaa gcc ctc       1248
Phe Gln Ser Pro Ser Phe Cys Pro Asn Pro Pro Gly Leu Glu Ala Leu           
                405                 410                 415               

agc ccc aac acc agc tgc cgc cac ttc cct ctg ctg gtc agt agc agc       1296
Ser Pro Asn Thr Ser Cys Arg His Phe Pro Leu Leu Val Ser Ser Ser           
            420                 425                 430                   

ttc tca cgt gtg gac cta ttc aat ggg ctg ttg gga cca gta cag gtc       1344
Phe Ser Arg Val Asp Leu Phe Asn Gly Leu Leu Gly Pro Val Gln Val           
        435                 440                 445                       

act gca ttg tat gtg aca cgc ctt gac aac gtc aca gtg gca cac atg       1392
Thr Ala Leu Tyr Val Thr Arg Leu Asp Asn Val Thr Val Ala His Met           
    450                 455                 460                           

ggc aca atg gat ggg cgt atc ctg cag gtg gag ctg gtc agg tca cta       1440
Gly Thr Met Asp Gly Arg Ile Leu Gln Val Glu Leu Val Arg Ser Leu           
465                 470                 475                 480           

aac tac ttg ctg tat gtg tcc aac ttc tca ctg ggt gac agt ggg cag       1488
Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu Gly Asp Ser Gly Gln           
                485                 490                 495               

ccc gtg cag cgg gat gtc agt cgt ctt ggg gac cac cta ctc ttt gcc       1536
Pro Val Gln Arg Asp Val Ser Arg Leu Gly Asp His Leu Leu Phe Ala           
            500                 505                 510                   

tct ggg gac cag gtt ttc cag gta cct atc caa ggc cct ggc tgc cgc       1584
Ser Gly Asp Gln Val Phe Gln Val Pro Ile Gln Gly Pro Gly Cys Arg           
        515                 520                 525                       

cac ttc ctg acc tgt ggg cgt tgc cta agg gca tgg cat ttc atg ggc       1632
His Phe Leu Thr Cys Gly Arg Cys Leu Arg Ala Trp His Phe Met Gly           
    530                 535                 540                           

tgt ggc tgg tgt ggg aac atg tgc ggc cag cag aag gag tgt cct ggc       1680
Cys Gly Trp Cys Gly Asn Met Cys Gly Gln Gln Lys Glu Cys Pro Gly           
545                 550                 555                 560           

tcc tgg caa cag gac cac tgc cca cct aag ctt act gag ttc cac ccc       1728
Ser Trp Gln Gln Asp His Cys Pro Pro Lys Leu Thr Glu Phe His Pro           
                565                 570                 575               

cac agt gga cct cta agg ggc agt aca agg ctg acc ctg tgt ggc tcc       1776
His Ser Gly Pro Leu Arg Gly Ser Thr Arg Leu Thr Leu Cys Gly Ser           
            580                 585                 590                   

aac ttc tac ctt cac cct tct ggt ctg gtg cct gag gga acc cat cag       1824
Asn Phe Tyr Leu His Pro Ser Gly Leu Val Pro Glu Gly Thr His Gln           
        595                 600                 605                       

gtc act gtg ggc caa agt ccc tgc cgg cca ctg ccc aag gac agc tca       1872
Val Thr Val Gly Gln Ser Pro Cys Arg Pro Leu Pro Lys Asp Ser Ser           
    610                 615                 620                           

aaa ctc aga cca gtg ccc cgg aaa gac ttt gta gag gag ttt gag tgt       1920
Lys Leu Arg Pro Val Pro Arg Lys Asp Phe Val Glu Glu Phe Glu Cys           
625                 630                 635                 640           

gaa ctg gag ccc ttg ggc acc cag gca gtg ggg cct acc aac gtc agc       1968
Glu Leu Glu Pro Leu Gly Thr Gln Ala Val Gly Pro Thr Asn Val Ser           
                645                 650                 655               

ctc acc gtg act aac atg cca ccg ggc aag cac ttc cgg gta gac ggc       2016
Leu Thr Val Thr Asn Met Pro Pro Gly Lys His Phe Arg Val Asp Gly           
            660                 665                 670                   

acc tcc gtg ctg aga ggc ttc tct ttc atg gag cca gtg ctg ata gca       2064
Thr Ser Val Leu Arg Gly Phe Ser Phe Met Glu Pro Val Leu Ile Ala           
        675                 680                 685                       

gtg caa ccc ctc ttt ggc cca cgg gca gga ggc acc tgt ctc act ctt       2112
Val Gln Pro Leu Phe Gly Pro Arg Ala Gly Gly Thr Cys Leu Thr Leu           
    690                 695                 700                           

gaa ggc cag agt ctg tct gta ggc acc agc cgg gct gtg ctg gtc aat       2160
Glu Gly Gln Ser Leu Ser Val Gly Thr Ser Arg Ala Val Leu Val Asn           
705                 710                 715                 720           

ggg act gag tgt ctg cta gca cgg gtc agt gag ggg cag ctt tta tgt       2208
Gly Thr Glu Cys Leu Leu Ala Arg Val Ser Glu Gly Gln Leu Leu Cys           
                725                 730                 735               

gcc aca ccc cct ggg gcc acg gtg gcc agt gtc ccc ctt agc ctg cag       2256
Ala Thr Pro Pro Gly Ala Thr Val Ala Ser Val Pro Leu Ser Leu Gln           
            740                 745                 750                   

gtg ggg ggt gcc cag gta cct ggt tcc tgg acc ttc cag tac aga gaa       2304
Val Gly Gly Ala Gln Val Pro Gly Ser Trp Thr Phe Gln Tyr Arg Glu           
        755                 760                 765                       

gac cct gtc gtg cta agc atc agc ccc aac tgt ggc tac atc aac tcc       2352
Asp Pro Val Val Leu Ser Ile Ser Pro Asn Cys Gly Tyr Ile Asn Ser           
    770                 775                 780                           

cac atc acc atc tgt ggc cag cat cta act tca gca tgg cac tta gtg       2400
His Ile Thr Ile Cys Gly Gln His Leu Thr Ser Ala Trp His Leu Val           
785                 790                 795                 800           

ctg tca ttc cat gac ggg ctt agg gca gtg gaa agc agg tgt gag agg       2448
Leu Ser Phe His Asp Gly Leu Arg Ala Val Glu Ser Arg Cys Glu Arg           
                805                 810                 815               

cag ctt cca gag cag cag ctg tgc cgc ctt cct gaa tat gtg gtc cga       2496
Gln Leu Pro Glu Gln Gln Leu Cys Arg Leu Pro Glu Tyr Val Val Arg           
            820                 825                 830                   

gac ccc cag gga tgg gtg gca ggg aat ctg agt gcc cga ggg gat gga       2544
Asp Pro Gln Gly Trp Val Ala Gly Asn Leu Ser Ala Arg Gly Asp Gly           
        835                 840                 845                       

gct gct ggc ttt aca ctg cct ggc ttt cgc ttc cta ccc cca ccc cat       2592
Ala Ala Gly Phe Thr Leu Pro Gly Phe Arg Phe Leu Pro Pro Pro His           
    850                 855                 860                           

cca ccc agt gcc aac cta gtt cca ctg aag cct gag gag cat gcc att       2640
Pro Pro Ser Ala Asn Leu Val Pro Leu Lys Pro Glu Glu His Ala Ile           
865                 870                 875                 880           

aag ttt gag tat att ggg ctg ggc gct gtg gct gac tgt gtg ggt atc       2688
Lys Phe Glu Tyr Ile Gly Leu Gly Ala Val Ala Asp Cys Val Gly Ile           
                885                 890                 895               

aac gtg acc gtg ggt ggt gag agc tgc cag cac gag ttc cgg ggg gac       2736
Asn Val Thr Val Gly Gly Glu Ser Cys Gln His Glu Phe Arg Gly Asp           
            900                 905                 910                   

atg gtt gtc tgc ccc ctg ccc cca tcc ctg cag ctt ggc cag gat ggt       2784
Met Val Val Cys Pro Leu Pro Pro Ser Leu Gln Leu Gly Gln Asp Gly           
        915                 920                 925                       

gcc cca ttg cag gtc tgc gta gat ggt gaa tgt cat atc ctg ggt aga       2832
Ala Pro Leu Gln Val Cys Val Asp Gly Glu Cys His Ile Leu Gly Arg           
    930                 935                 940                           

gtg gtg cgg cca ggg cca gat ggg gtc cca cag agc acg ctc ctt ggt       2880
Val Val Arg Pro Gly Pro Asp Gly Val Pro Gln Ser Thr Leu Leu Gly           
945                 950                 955                 960           

atc ctg ctg cct ttg ctg ctg ctt gtg gct gca ctg gcg act gca ctg       2928
Ile Leu Leu Pro Leu Leu Leu Leu Val Ala Ala Leu Ala Thr Ala Leu           
                965                 970                 975               

gtc ttc agc tac tgg tgg cgg agg aag cag cta gtt ctt cct ccc aac       2976
Val Phe Ser Tyr Trp Trp Arg Arg Lys Gln Leu Val Leu Pro Pro Asn           
            980                 985                 990                   

ctg aat gac ctg gca tcc ctg gac  cag act gct gga gcc  aca ccc ctg     3024
Leu Asn Asp Leu Ala Ser Leu Asp  Gln Thr Ala Gly Ala  Thr Pro Leu         
        995                 1000                 1005                     

cct att  ctg tac tcg ggc tct  gac tac aga agt ggc  ctt gca ctc        3069
Pro Ile  Leu Tyr Ser Gly Ser  Asp Tyr Arg Ser Gly  Leu Ala Leu            
    1010                 1015                 1020                        

cct gcc  att gat ggt ctg gat  tcc acc act tgt gtc  cat gga gca        3114
Pro Ala  Ile Asp Gly Leu Asp  Ser Thr Thr Cys Val  His Gly Ala            
    1025                 1030                 1035                        

tcc ttc  tcc gat agt gaa gat  gaa tcc tgt gtg cca  ctg ctg cgg        3159
Ser Phe  Ser Asp Ser Glu Asp  Glu Ser Cys Val Pro  Leu Leu Arg            
    1040                 1045                 1050                        

aaa gag  tcc atc cag cta agg  gac ctg gac tct gcg  ctc ttg gct        3204
Lys Glu  Ser Ile Gln Leu Arg  Asp Leu Asp Ser Ala  Leu Leu Ala            
    1055                 1060                 1065                        

gag gtc  aag gat gtg ctg att  ccc cat gag cgg gtg  gtc acc cac        3249
Glu Val  Lys Asp Val Leu Ile  Pro His Glu Arg Val  Val Thr His            
    1070                 1075                 1080                        

agt gac  cga gtc att ggc aaa  ggc cac ttt gga gtt  gtc tac cac        3294
Ser Asp  Arg Val Ile Gly Lys  Gly His Phe Gly Val  Val Tyr His            
    1085                 1090                 1095                        

gga gaa  tac ata gac cag gcc  cag aat cga atc caa  tgt gcc atc        3339
Gly Glu  Tyr Ile Asp Gln Ala  Gln Asn Arg Ile Gln  Cys Ala Ile            
    1100                 1105                 1110                        

aag tca  cta agt cgc atc aca  gag atg cag cag gtg  gag gcc ttc        3384
Lys Ser  Leu Ser Arg Ile Thr  Glu Met Gln Gln Val  Glu Ala Phe            
    1115                 1120                 1125                        

ctg cga  gag ggg ctg ctc atg  cgt ggc ctg aac cac  ccg aat gtg        3429
Leu Arg  Glu Gly Leu Leu Met  Arg Gly Leu Asn His  Pro Asn Val            
    1130                 1135                 1140                        

ctg gct  ctc att ggt atc atg  ttg cca cct gag ggc  ctg ccc cat        3474
Leu Ala  Leu Ile Gly Ile Met  Leu Pro Pro Glu Gly  Leu Pro His            
    1145                 1150                 1155                        

gtg ctg  ctg ccc tat atg tgc  cac ggt gac ctg ctc  cag ttc atc        3519
Val Leu  Leu Pro Tyr Met Cys  His Gly Asp Leu Leu  Gln Phe Ile            
    1160                 1165                 1170                        

cgc tca  cct cag cgg aac ccc  acc gtg aag gac ctc  atc agc ttt        3564
Arg Ser  Pro Gln Arg Asn Pro  Thr Val Lys Asp Leu  Ile Ser Phe            
    1175                 1180                 1185                        

ggc ctg  cag gta gcc cgc ggc  atg gag tac ctg gca  gag cag aag        3609
Gly Leu  Gln Val Ala Arg Gly  Met Glu Tyr Leu Ala  Glu Gln Lys            
    1190                 1195                 1200                        

ttt gtg  cac agg gac ctg gct  gcg cgg aac tgc atg  ctg gac gag        3654
Phe Val  His Arg Asp Leu Ala  Ala Arg Asn Cys Met  Leu Asp Glu            
    1205                 1210                 1215                        

tca ttc  aca gtc aag gtg gct  gac ttt ggt ttg gcc  cgc gac atc        3699
Ser Phe  Thr Val Lys Val Ala  Asp Phe Gly Leu Ala  Arg Asp Ile            
    1220                 1225                 1230                        

ctg gac  agg gag tac tat agt  gtt caa cag cat cgc  cac gct cgc        3744
Leu Asp  Arg Glu Tyr Tyr Ser  Val Gln Gln His Arg  His Ala Arg            
    1235                 1240                 1245                        

cta cct  gtg aag tgg atg gcg  ctg gag agc ctg cag  acc tat aga        3789
Leu Pro  Val Lys Trp Met Ala  Leu Glu Ser Leu Gln  Thr Tyr Arg            
    1250                 1255                 1260                        

ttt acc  acc aag tct gat gtg  tgg tca ttt ggt gtg  ctg ctg tgg        3834
Phe Thr  Thr Lys Ser Asp Val  Trp Ser Phe Gly Val  Leu Leu Trp            
    1265                 1270                 1275                        

gaa ctg  ctg aca cgg ggt gcc  cca cca tac cgc cac  att gac cct        3879
Glu Leu  Leu Thr Arg Gly Ala  Pro Pro Tyr Arg His  Ile Asp Pro            
    1280                 1285                 1290                        

ttt gac  ctt acc cac ttc ctg  gcc cag ggt cgg cgc  ctg ccc cag        3924
Phe Asp  Leu Thr His Phe Leu  Ala Gln Gly Arg Arg  Leu Pro Gln            
    1295                 1300                 1305                        

cct gag  tat tgc cct gat tct  ctg tac caa gtg atg  cag caa tgc        3969
Pro Glu  Tyr Cys Pro Asp Ser  Leu Tyr Gln Val Met  Gln Gln Cys            
    1310                 1315                 1320                        

tgg gag  gca gac cca gca gtg  cga ccc acc ttc aga  gta cta gtg        4014
Trp Glu  Ala Asp Pro Ala Val  Arg Pro Thr Phe Arg  Val Leu Val            
    1325                 1330                 1335                        

ggg gag  gtg gag cag ata gtg  tct gca ctg ctt ggg  gac cat tat        4059
Gly Glu  Val Glu Gln Ile Val  Ser Ala Leu Leu Gly  Asp His Tyr            
    1340                 1345                 1350                        

gtg cag  ctg cca gca acc tac  atg aac ttg ggc ccc  agc acc tcg        4104
Val Gln  Leu Pro Ala Thr Tyr  Met Asn Leu Gly Pro  Ser Thr Ser            
    1355                 1360                 1365                        

cat gag  atg aat gtg cgt cca  gaa cag ccg cag ttc  tca ccc atg        4149
His Glu  Met Asn Val Arg Pro  Glu Gln Pro Gln Phe  Ser Pro Met            
    1370                 1375                 1380                        

cca ggg  aat gta cgc cgg ccc  cgg cca ctc tca gag  cct cct cgg        4194
Pro Gly  Asn Val Arg Arg Pro  Arg Pro Leu Ser Glu  Pro Pro Arg            
    1385                 1390                 1395                        

ccc act  tga                                                          4203
Pro Thr                                                                   
    1400                                                                  


<210>  42
<211>  1400
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Glu Leu Leu Pro Pro Leu Pro Gln Ser Phe Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Ala Lys Pro Ala Ala Gly Glu Asp Trp Gln Cys Pro Arg Thr 
            20                  25                  30          


Pro Tyr Ala Ala Ser Arg Asp Phe Asp Val Lys Tyr Val Val Pro Ser 
        35                  40                  45              


Phe Ser Ala Gly Gly Leu Val Gln Ala Met Val Thr Tyr Glu Gly Asp 
    50                  55                  60                  


Arg Asn Glu Ser Ala Val Phe Val Ala Ile Arg Asn Arg Leu His Val 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Lys Ser Val Gln Ser Leu Ala Thr Gly Pro Ala 
                85                  90                  95      


Gly Asp Pro Gly Cys Gln Thr Cys Ala Ala Cys Gly Pro Gly Pro His 
            100                 105                 110         


Gly Pro Pro Gly Asp Thr Asp Thr Lys Val Leu Val Leu Asp Pro Ala 
        115                 120                 125             


Leu Pro Ala Leu Val Ser Cys Gly Ser Ser Leu Gln Gly Arg Cys Phe 
    130                 135                 140                 


Leu His Asp Leu Glu Pro Gln Gly Thr Ala Val His Leu Ala Ala Pro 
145                 150                 155                 160 


Ala Cys Leu Phe Ser Ala His His Asn Arg Pro Asp Asp Cys Pro Asp 
                165                 170                 175     


Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln Gly 
            180                 185                 190         


Gln Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Ala Ala Val Ala 
        195                 200                 205             


Ala Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ala Asp 
    210                 215                 220                 


Ala Ser Gly Phe Ala Pro Gly Phe Val Ala Leu Ser Val Leu Pro Lys 
225                 230                 235                 240 


His Leu Val Ser Tyr Ser Ile Glu Tyr Val His Ser Phe His Thr Gly 
                245                 250                 255     


Ala Phe Val Tyr Phe Leu Thr Val Gln Pro Ala Ser Val Thr Asp Asp 
            260                 265                 270         


Pro Ser Ala Leu His Thr Arg Leu Ala Arg Leu Ser Ala Thr Glu Pro 
        275                 280                 285             


Glu Leu Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys Arg Phe Ala Pro 
    290                 295                 300                 


Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Gly Gln Pro Tyr Pro Val 
305                 310                 315                 320 


Leu Arg Val Ala His Ser Ala Pro Val Gly Ala Gln Leu Ala Thr Glu 
                325                 330                 335     


Leu Ser Ile Ala Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val Thr 
            340                 345                 350         


Gly Lys Asp Gly Gly Pro Gly Val Gly Pro Asn Ser Val Val Cys Ala 
        355                 360                 365             


Phe Pro Ile Asp Leu Leu Asp Thr Leu Ile Asp Glu Gly Val Glu Arg 
    370                 375                 380                 


Cys Cys Glu Ser Pro Val His Pro Gly Leu Arg Arg Gly Leu Asp Phe 
385                 390                 395                 400 


Phe Gln Ser Pro Ser Phe Cys Pro Asn Pro Pro Gly Leu Glu Ala Leu 
                405                 410                 415     


Ser Pro Asn Thr Ser Cys Arg His Phe Pro Leu Leu Val Ser Ser Ser 
            420                 425                 430         


Phe Ser Arg Val Asp Leu Phe Asn Gly Leu Leu Gly Pro Val Gln Val 
        435                 440                 445             


Thr Ala Leu Tyr Val Thr Arg Leu Asp Asn Val Thr Val Ala His Met 
    450                 455                 460                 


Gly Thr Met Asp Gly Arg Ile Leu Gln Val Glu Leu Val Arg Ser Leu 
465                 470                 475                 480 


Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu Gly Asp Ser Gly Gln 
                485                 490                 495     


Pro Val Gln Arg Asp Val Ser Arg Leu Gly Asp His Leu Leu Phe Ala 
            500                 505                 510         


Ser Gly Asp Gln Val Phe Gln Val Pro Ile Gln Gly Pro Gly Cys Arg 
        515                 520                 525             


His Phe Leu Thr Cys Gly Arg Cys Leu Arg Ala Trp His Phe Met Gly 
    530                 535                 540                 


Cys Gly Trp Cys Gly Asn Met Cys Gly Gln Gln Lys Glu Cys Pro Gly 
545                 550                 555                 560 


Ser Trp Gln Gln Asp His Cys Pro Pro Lys Leu Thr Glu Phe His Pro 
                565                 570                 575     


His Ser Gly Pro Leu Arg Gly Ser Thr Arg Leu Thr Leu Cys Gly Ser 
            580                 585                 590         


Asn Phe Tyr Leu His Pro Ser Gly Leu Val Pro Glu Gly Thr His Gln 
        595                 600                 605             


Val Thr Val Gly Gln Ser Pro Cys Arg Pro Leu Pro Lys Asp Ser Ser 
    610                 615                 620                 


Lys Leu Arg Pro Val Pro Arg Lys Asp Phe Val Glu Glu Phe Glu Cys 
625                 630                 635                 640 


Glu Leu Glu Pro Leu Gly Thr Gln Ala Val Gly Pro Thr Asn Val Ser 
                645                 650                 655     


Leu Thr Val Thr Asn Met Pro Pro Gly Lys His Phe Arg Val Asp Gly 
            660                 665                 670         


Thr Ser Val Leu Arg Gly Phe Ser Phe Met Glu Pro Val Leu Ile Ala 
        675                 680                 685             


Val Gln Pro Leu Phe Gly Pro Arg Ala Gly Gly Thr Cys Leu Thr Leu 
    690                 695                 700                 


Glu Gly Gln Ser Leu Ser Val Gly Thr Ser Arg Ala Val Leu Val Asn 
705                 710                 715                 720 


Gly Thr Glu Cys Leu Leu Ala Arg Val Ser Glu Gly Gln Leu Leu Cys 
                725                 730                 735     


Ala Thr Pro Pro Gly Ala Thr Val Ala Ser Val Pro Leu Ser Leu Gln 
            740                 745                 750         


Val Gly Gly Ala Gln Val Pro Gly Ser Trp Thr Phe Gln Tyr Arg Glu 
        755                 760                 765             


Asp Pro Val Val Leu Ser Ile Ser Pro Asn Cys Gly Tyr Ile Asn Ser 
    770                 775                 780                 


His Ile Thr Ile Cys Gly Gln His Leu Thr Ser Ala Trp His Leu Val 
785                 790                 795                 800 


Leu Ser Phe His Asp Gly Leu Arg Ala Val Glu Ser Arg Cys Glu Arg 
                805                 810                 815     


Gln Leu Pro Glu Gln Gln Leu Cys Arg Leu Pro Glu Tyr Val Val Arg 
            820                 825                 830         


Asp Pro Gln Gly Trp Val Ala Gly Asn Leu Ser Ala Arg Gly Asp Gly 
        835                 840                 845             


Ala Ala Gly Phe Thr Leu Pro Gly Phe Arg Phe Leu Pro Pro Pro His 
    850                 855                 860                 


Pro Pro Ser Ala Asn Leu Val Pro Leu Lys Pro Glu Glu His Ala Ile 
865                 870                 875                 880 


Lys Phe Glu Tyr Ile Gly Leu Gly Ala Val Ala Asp Cys Val Gly Ile 
                885                 890                 895     


Asn Val Thr Val Gly Gly Glu Ser Cys Gln His Glu Phe Arg Gly Asp 
            900                 905                 910         


Met Val Val Cys Pro Leu Pro Pro Ser Leu Gln Leu Gly Gln Asp Gly 
        915                 920                 925             


Ala Pro Leu Gln Val Cys Val Asp Gly Glu Cys His Ile Leu Gly Arg 
    930                 935                 940                 


Val Val Arg Pro Gly Pro Asp Gly Val Pro Gln Ser Thr Leu Leu Gly 
945                 950                 955                 960 


Ile Leu Leu Pro Leu Leu Leu Leu Val Ala Ala Leu Ala Thr Ala Leu 
                965                 970                 975     


Val Phe Ser Tyr Trp Trp Arg Arg Lys Gln Leu Val Leu Pro Pro Asn 
            980                 985                 990         


Leu Asn Asp Leu Ala Ser Leu Asp  Gln Thr Ala Gly Ala  Thr Pro Leu 
        995                 1000                 1005             


Pro Ile  Leu Tyr Ser Gly Ser  Asp Tyr Arg Ser Gly  Leu Ala Leu 
    1010                 1015                 1020             


Pro Ala  Ile Asp Gly Leu Asp  Ser Thr Thr Cys Val  His Gly Ala 
    1025                 1030                 1035             


Ser Phe  Ser Asp Ser Glu Asp  Glu Ser Cys Val Pro  Leu Leu Arg 
    1040                 1045                 1050             


Lys Glu  Ser Ile Gln Leu Arg  Asp Leu Asp Ser Ala  Leu Leu Ala 
    1055                 1060                 1065             


Glu Val  Lys Asp Val Leu Ile  Pro His Glu Arg Val  Val Thr His 
    1070                 1075                 1080             


Ser Asp  Arg Val Ile Gly Lys  Gly His Phe Gly Val  Val Tyr His 
    1085                 1090                 1095             


Gly Glu  Tyr Ile Asp Gln Ala  Gln Asn Arg Ile Gln  Cys Ala Ile 
    1100                 1105                 1110             


Lys Ser  Leu Ser Arg Ile Thr  Glu Met Gln Gln Val  Glu Ala Phe 
    1115                 1120                 1125             


Leu Arg  Glu Gly Leu Leu Met  Arg Gly Leu Asn His  Pro Asn Val 
    1130                 1135                 1140             


Leu Ala  Leu Ile Gly Ile Met  Leu Pro Pro Glu Gly  Leu Pro His 
    1145                 1150                 1155             


Val Leu  Leu Pro Tyr Met Cys  His Gly Asp Leu Leu  Gln Phe Ile 
    1160                 1165                 1170             


Arg Ser  Pro Gln Arg Asn Pro  Thr Val Lys Asp Leu  Ile Ser Phe 
    1175                 1180                 1185             


Gly Leu  Gln Val Ala Arg Gly  Met Glu Tyr Leu Ala  Glu Gln Lys 
    1190                 1195                 1200             


Phe Val  His Arg Asp Leu Ala  Ala Arg Asn Cys Met  Leu Asp Glu 
    1205                 1210                 1215             


Ser Phe  Thr Val Lys Val Ala  Asp Phe Gly Leu Ala  Arg Asp Ile 
    1220                 1225                 1230             


Leu Asp  Arg Glu Tyr Tyr Ser  Val Gln Gln His Arg  His Ala Arg 
    1235                 1240                 1245             


Leu Pro  Val Lys Trp Met Ala  Leu Glu Ser Leu Gln  Thr Tyr Arg 
    1250                 1255                 1260             


Phe Thr  Thr Lys Ser Asp Val  Trp Ser Phe Gly Val  Leu Leu Trp 
    1265                 1270                 1275             


Glu Leu  Leu Thr Arg Gly Ala  Pro Pro Tyr Arg His  Ile Asp Pro 
    1280                 1285                 1290             


Phe Asp  Leu Thr His Phe Leu  Ala Gln Gly Arg Arg  Leu Pro Gln 
    1295                 1300                 1305             


Pro Glu  Tyr Cys Pro Asp Ser  Leu Tyr Gln Val Met  Gln Gln Cys 
    1310                 1315                 1320             


Trp Glu  Ala Asp Pro Ala Val  Arg Pro Thr Phe Arg  Val Leu Val 
    1325                 1330                 1335             


Gly Glu  Val Glu Gln Ile Val  Ser Ala Leu Leu Gly  Asp His Tyr 
    1340                 1345                 1350             


Val Gln  Leu Pro Ala Thr Tyr  Met Asn Leu Gly Pro  Ser Thr Ser 
    1355                 1360                 1365             


His Glu  Met Asn Val Arg Pro  Glu Gln Pro Gln Phe  Ser Pro Met 
    1370                 1375                 1380             


Pro Gly  Asn Val Arg Arg Pro  Arg Pro Leu Ser Glu  Pro Pro Arg 
    1385                 1390                 1395             


Pro Thr  
    1400 


<210>  43
<211>  2745
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(2745)

<400>  43
atg gag ctc ctc ccg ccg ctg cct cag tcc ttc ctg ttg ctg ctg ctg         48
Met Glu Leu Leu Pro Pro Leu Pro Gln Ser Phe Leu Leu Leu Leu Leu           
1               5                   10                  15                

ttg cct gcc aag ccc gcg gcg ggc gag gac tgg cag tgc ccg cgc acc         96
Leu Pro Ala Lys Pro Ala Ala Gly Glu Asp Trp Gln Cys Pro Arg Thr           
            20                  25                  30                    

ccc tac gcg gcc tct cgc gac ttt gac gtg aag tac gtg gtg ccc agc        144
Pro Tyr Ala Ala Ser Arg Asp Phe Asp Val Lys Tyr Val Val Pro Ser           
        35                  40                  45                        

ttc tcc gcc gga ggc ctg gta cag gcc atg gtg acc tac gag ggc gac        192
Phe Ser Ala Gly Gly Leu Val Gln Ala Met Val Thr Tyr Glu Gly Asp           
    50                  55                  60                            

aga aat gag agt gct gtg ttt gta gcc ata cgc aat cgc ctg cat gtg        240
Arg Asn Glu Ser Ala Val Phe Val Ala Ile Arg Asn Arg Leu His Val           
65                  70                  75                  80            

ctt ggg cct gac ctg aag tct gtc cag agc ctg gcc acg ggc cct gct        288
Leu Gly Pro Asp Leu Lys Ser Val Gln Ser Leu Ala Thr Gly Pro Ala           
                85                  90                  95                

gga gac cct ggc tgc cag acg tgt gca gcc tgt ggc cca gga ccc cac        336
Gly Asp Pro Gly Cys Gln Thr Cys Ala Ala Cys Gly Pro Gly Pro His           
            100                 105                 110                   

ggc cct ccc ggt gac aca gac aca aag gtg ctg gtg ctg gat ccc gcg        384
Gly Pro Pro Gly Asp Thr Asp Thr Lys Val Leu Val Leu Asp Pro Ala           
        115                 120                 125                       

ctg cct gcg ctg gtc agt tgt ggc tcc agc ctg cag ggc cgc tgc ttc        432
Leu Pro Ala Leu Val Ser Cys Gly Ser Ser Leu Gln Gly Arg Cys Phe           
    130                 135                 140                           

ctg cat gac cta gag ccc caa ggg aca gcc gtg cat ctg gca gcg cca        480
Leu His Asp Leu Glu Pro Gln Gly Thr Ala Val His Leu Ala Ala Pro           
145                 150                 155                 160           

gcc tgc ctc ttc tca gcc cac cat aac cgg ccc gat gac tgc ccc gac        528
Ala Cys Leu Phe Ser Ala His His Asn Arg Pro Asp Asp Cys Pro Asp           
                165                 170                 175               

tgt gtg gcc agc cca ttg ggc acc cgt gta act gtg gtt gag caa ggc        576
Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln Gly           
            180                 185                 190                   

cag gcc tcc tat ttc tac gtg gca tcc tca ctg gac gca gcc gtg gct        624
Gln Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Ala Ala Val Ala           
        195                 200                 205                       

gcc agc ttc agc cca cgc tca gtg tct atc agg cgt ctc aag gct gac        672
Ala Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ala Asp           
    210                 215                 220                           

gcc tcg gga ttc gca ccg ggc ttt gtg gcg ttg tca gtg ctg ccc aag        720
Ala Ser Gly Phe Ala Pro Gly Phe Val Ala Leu Ser Val Leu Pro Lys           
225                 230                 235                 240           

cat ctt gtc tcc tac agt att gaa tac gtg cac agc ttc cac acg gga        768
His Leu Val Ser Tyr Ser Ile Glu Tyr Val His Ser Phe His Thr Gly           
                245                 250                 255               

gcc ttc gta tac ttc ctg act gta cag ccg gcc agc gtg aca gat gat        816
Ala Phe Val Tyr Phe Leu Thr Val Gln Pro Ala Ser Val Thr Asp Asp           
            260                 265                 270                   

cct agt gcc ctg cac aca cgc ctg gca cgg ctt agc gcc act gag cca        864
Pro Ser Ala Leu His Thr Arg Leu Ala Arg Leu Ser Ala Thr Glu Pro           
        275                 280                 285                       

gag ttg ggt gac tat cgg gag ctg gtc ctc gac tgc aga ttt gct cca        912
Glu Leu Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys Arg Phe Ala Pro           
    290                 295                 300                           

aaa cgc agg cgc cgg ggg gcc cca gaa ggc gga cag ccc tac cct gtg        960
Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Gly Gln Pro Tyr Pro Val           
305                 310                 315                 320           

ctg cgg gtg gcc cac tcc gct cca gtg ggt gcc caa ctt gcc act gag       1008
Leu Arg Val Ala His Ser Ala Pro Val Gly Ala Gln Leu Ala Thr Glu           
                325                 330                 335               

ctg agc atc gcc gag ggc cag gaa gta cta ttt ggg gtc ttt gtg act       1056
Leu Ser Ile Ala Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val Thr           
            340                 345                 350                   

ggc aag gat ggt ggt cct ggc gtg ggc ccc aac tct gtc gtc tgt gcc       1104
Gly Lys Asp Gly Gly Pro Gly Val Gly Pro Asn Ser Val Val Cys Ala           
        355                 360                 365                       

ttc ccc att gac ctg ctg gac aca cta att gat gag ggt gtg gag cgc       1152
Phe Pro Ile Asp Leu Leu Asp Thr Leu Ile Asp Glu Gly Val Glu Arg           
    370                 375                 380                           

tgt tgt gaa tcc cca gtc cat cca ggc ctc cgg cga ggc ctc gac ttc       1200
Cys Cys Glu Ser Pro Val His Pro Gly Leu Arg Arg Gly Leu Asp Phe           
385                 390                 395                 400           

ttc cag tcg ccc agt ttt tgc ccc aac ccg cct ggc ctg gaa gcc ctc       1248
Phe Gln Ser Pro Ser Phe Cys Pro Asn Pro Pro Gly Leu Glu Ala Leu           
                405                 410                 415               

agc ccc aac acc agc tgc cgc cac ttc cct ctg ctg gtc agt agc agc       1296
Ser Pro Asn Thr Ser Cys Arg His Phe Pro Leu Leu Val Ser Ser Ser           
            420                 425                 430                   

ttc tca cgt gtg gac cta ttc aat ggg ctg ttg gga cca gta cag gtc       1344
Phe Ser Arg Val Asp Leu Phe Asn Gly Leu Leu Gly Pro Val Gln Val           
        435                 440                 445                       

act gca ttg tat gtg aca cgc ctt gac aac gtc aca gtg gca cac atg       1392
Thr Ala Leu Tyr Val Thr Arg Leu Asp Asn Val Thr Val Ala His Met           
    450                 455                 460                           

ggc aca atg gat ggg cgt atc ctg cag gtg gag ctg gtc agg tca cta       1440
Gly Thr Met Asp Gly Arg Ile Leu Gln Val Glu Leu Val Arg Ser Leu           
465                 470                 475                 480           

aac tac ttg ctg tat gtg tcc aac ttc tca ctg ggt gac agt ggg cag       1488
Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu Gly Asp Ser Gly Gln           
                485                 490                 495               

ccc gtg cag cgg gat gtc agt cgt ctt ggg gac cac cta ctc ttt gcc       1536
Pro Val Gln Arg Asp Val Ser Arg Leu Gly Asp His Leu Leu Phe Ala           
            500                 505                 510                   

tct ggg gac cag gtt ttc cag gta cct atc caa ggc cct ggc tgc cgc       1584
Ser Gly Asp Gln Val Phe Gln Val Pro Ile Gln Gly Pro Gly Cys Arg           
        515                 520                 525                       

cac ttc ctg acc tgt ggg cgt tgc cta agg gca tgg cat ttc atg ggc       1632
His Phe Leu Thr Cys Gly Arg Cys Leu Arg Ala Trp His Phe Met Gly           
    530                 535                 540                           

tgt ggc tgg tgt ggg aac atg tgc ggc cag cag aag gag tgt cct ggc       1680
Cys Gly Trp Cys Gly Asn Met Cys Gly Gln Gln Lys Glu Cys Pro Gly           
545                 550                 555                 560           

tcc tgg caa cag gac cac tgc cca cct aag ctt act gag ttc cac ccc       1728
Ser Trp Gln Gln Asp His Cys Pro Pro Lys Leu Thr Glu Phe His Pro           
                565                 570                 575               

cac agt gga cct cta agg ggc agt aca agg ctg acc ctg tgt ggc tcc       1776
His Ser Gly Pro Leu Arg Gly Ser Thr Arg Leu Thr Leu Cys Gly Ser           
            580                 585                 590                   

aac ttc tac ctt cac cct tct ggt ctg gtg cct gag gga acc cat cag       1824
Asn Phe Tyr Leu His Pro Ser Gly Leu Val Pro Glu Gly Thr His Gln           
        595                 600                 605                       

gtc act gtg ggc caa agt ccc tgc cgg cca ctg ccc aag gac agc tca       1872
Val Thr Val Gly Gln Ser Pro Cys Arg Pro Leu Pro Lys Asp Ser Ser           
    610                 615                 620                           

aaa ctc aga cca gtg ccc cgg aaa gac ttt gta gag gag ttt gag tgt       1920
Lys Leu Arg Pro Val Pro Arg Lys Asp Phe Val Glu Glu Phe Glu Cys           
625                 630                 635                 640           

gaa ctg gag ccc ttg ggc acc cag gca gtg ggg cct acc aac gtc agc       1968
Glu Leu Glu Pro Leu Gly Thr Gln Ala Val Gly Pro Thr Asn Val Ser           
                645                 650                 655               

ctc acc gtg act aac atg cca ccg ggc aag cac ttc cgg gta gac ggc       2016
Leu Thr Val Thr Asn Met Pro Pro Gly Lys His Phe Arg Val Asp Gly           
            660                 665                 670                   

acc tcc gtg ctg aga ggc ttc tct ttc atg acc ggt acg gtc acc gac       2064
Thr Ser Val Leu Arg Gly Phe Ser Phe Met Thr Gly Thr Val Thr Asp           
        675                 680                 685                       

aaa act cac aca tgc cca ccg tgc cca gca cct gaa ctc ctg ggg gga       2112
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly           
    690                 695                 700                           

ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc       2160
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile           
705                 710                 715                 720           

tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc cac gaa       2208
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu           
                725                 730                 735               

gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag gtg cat       2256
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His           
            740                 745                 750                   

aat gcc aag aca aag ccg cgg gag gag cag tac aac agc acg tac cgt       2304
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg           
        755                 760                 765                       

gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat ggc aag       2352
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys           
    770                 775                 780                           

gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca gcc ccc atc gag       2400
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu           
785                 790                 795                 800           

aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag gtg tac       2448
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr           
                805                 810                 815               

acc ctg ccc cca tcc cgg gaa gag atg acc aag aac cag gtc agc ctg       2496
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu           
            820                 825                 830                   

acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg       2544
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp           
        835                 840                 845                       

gag agc aat ggg cag ccg gag aac aac tac aag acc acg cct ccc gtg       2592
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val           
    850                 855                 860                           

ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac       2640
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp           
865                 870                 875                 880           

aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat       2688
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His           
                885                 890                 895               

gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg       2736
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro           
            900                 905                 910                   

ggt aaa tga                                                           2745
Gly Lys                                                                   
                                                                          


<210>  44
<211>  914
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44

Met Glu Leu Leu Pro Pro Leu Pro Gln Ser Phe Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Ala Lys Pro Ala Ala Gly Glu Asp Trp Gln Cys Pro Arg Thr 
            20                  25                  30          


Pro Tyr Ala Ala Ser Arg Asp Phe Asp Val Lys Tyr Val Val Pro Ser 
        35                  40                  45              


Phe Ser Ala Gly Gly Leu Val Gln Ala Met Val Thr Tyr Glu Gly Asp 
    50                  55                  60                  


Arg Asn Glu Ser Ala Val Phe Val Ala Ile Arg Asn Arg Leu His Val 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Lys Ser Val Gln Ser Leu Ala Thr Gly Pro Ala 
                85                  90                  95      


Gly Asp Pro Gly Cys Gln Thr Cys Ala Ala Cys Gly Pro Gly Pro His 
            100                 105                 110         


Gly Pro Pro Gly Asp Thr Asp Thr Lys Val Leu Val Leu Asp Pro Ala 
        115                 120                 125             


Leu Pro Ala Leu Val Ser Cys Gly Ser Ser Leu Gln Gly Arg Cys Phe 
    130                 135                 140                 


Leu His Asp Leu Glu Pro Gln Gly Thr Ala Val His Leu Ala Ala Pro 
145                 150                 155                 160 


Ala Cys Leu Phe Ser Ala His His Asn Arg Pro Asp Asp Cys Pro Asp 
                165                 170                 175     


Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln Gly 
            180                 185                 190         


Gln Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Ala Ala Val Ala 
        195                 200                 205             


Ala Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ala Asp 
    210                 215                 220                 


Ala Ser Gly Phe Ala Pro Gly Phe Val Ala Leu Ser Val Leu Pro Lys 
225                 230                 235                 240 


His Leu Val Ser Tyr Ser Ile Glu Tyr Val His Ser Phe His Thr Gly 
                245                 250                 255     


Ala Phe Val Tyr Phe Leu Thr Val Gln Pro Ala Ser Val Thr Asp Asp 
            260                 265                 270         


Pro Ser Ala Leu His Thr Arg Leu Ala Arg Leu Ser Ala Thr Glu Pro 
        275                 280                 285             


Glu Leu Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys Arg Phe Ala Pro 
    290                 295                 300                 


Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Gly Gln Pro Tyr Pro Val 
305                 310                 315                 320 


Leu Arg Val Ala His Ser Ala Pro Val Gly Ala Gln Leu Ala Thr Glu 
                325                 330                 335     


Leu Ser Ile Ala Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val Thr 
            340                 345                 350         


Gly Lys Asp Gly Gly Pro Gly Val Gly Pro Asn Ser Val Val Cys Ala 
        355                 360                 365             


Phe Pro Ile Asp Leu Leu Asp Thr Leu Ile Asp Glu Gly Val Glu Arg 
    370                 375                 380                 


Cys Cys Glu Ser Pro Val His Pro Gly Leu Arg Arg Gly Leu Asp Phe 
385                 390                 395                 400 


Phe Gln Ser Pro Ser Phe Cys Pro Asn Pro Pro Gly Leu Glu Ala Leu 
                405                 410                 415     


Ser Pro Asn Thr Ser Cys Arg His Phe Pro Leu Leu Val Ser Ser Ser 
            420                 425                 430         


Phe Ser Arg Val Asp Leu Phe Asn Gly Leu Leu Gly Pro Val Gln Val 
        435                 440                 445             


Thr Ala Leu Tyr Val Thr Arg Leu Asp Asn Val Thr Val Ala His Met 
    450                 455                 460                 


Gly Thr Met Asp Gly Arg Ile Leu Gln Val Glu Leu Val Arg Ser Leu 
465                 470                 475                 480 


Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu Gly Asp Ser Gly Gln 
                485                 490                 495     


Pro Val Gln Arg Asp Val Ser Arg Leu Gly Asp His Leu Leu Phe Ala 
            500                 505                 510         


Ser Gly Asp Gln Val Phe Gln Val Pro Ile Gln Gly Pro Gly Cys Arg 
        515                 520                 525             


His Phe Leu Thr Cys Gly Arg Cys Leu Arg Ala Trp His Phe Met Gly 
    530                 535                 540                 


Cys Gly Trp Cys Gly Asn Met Cys Gly Gln Gln Lys Glu Cys Pro Gly 
545                 550                 555                 560 


Ser Trp Gln Gln Asp His Cys Pro Pro Lys Leu Thr Glu Phe His Pro 
                565                 570                 575     


His Ser Gly Pro Leu Arg Gly Ser Thr Arg Leu Thr Leu Cys Gly Ser 
            580                 585                 590         


Asn Phe Tyr Leu His Pro Ser Gly Leu Val Pro Glu Gly Thr His Gln 
        595                 600                 605             


Val Thr Val Gly Gln Ser Pro Cys Arg Pro Leu Pro Lys Asp Ser Ser 
    610                 615                 620                 


Lys Leu Arg Pro Val Pro Arg Lys Asp Phe Val Glu Glu Phe Glu Cys 
625                 630                 635                 640 


Glu Leu Glu Pro Leu Gly Thr Gln Ala Val Gly Pro Thr Asn Val Ser 
                645                 650                 655     


Leu Thr Val Thr Asn Met Pro Pro Gly Lys His Phe Arg Val Asp Gly 
            660                 665                 670         


Thr Ser Val Leu Arg Gly Phe Ser Phe Met Thr Gly Thr Val Thr Asp 
        675                 680                 685             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    690                 695                 700                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
705                 710                 715                 720 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                725                 730                 735     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            740                 745                 750         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        755                 760                 765             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    770                 775                 780                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
785                 790                 795                 800 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                805                 810                 815     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            820                 825                 830         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        835                 840                 845             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    850                 855                 860                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
865                 870                 875                 880 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                885                 890                 895     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            900                 905                 910         


Gly Lys 
        


<210>  45
<211>  2079
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(2079)

<400>  45
atg gag ctc ctc ccg ccg ctg cct cag tcc ttc ctg ttg ctg ctg ctg         48
Met Glu Leu Leu Pro Pro Leu Pro Gln Ser Phe Leu Leu Leu Leu Leu           
1               5                   10                  15                

ttg cct gcc aag ccc gcg gcg ggc gag gac tgg cag tgc ccg cgc acc         96
Leu Pro Ala Lys Pro Ala Ala Gly Glu Asp Trp Gln Cys Pro Arg Thr           
            20                  25                  30                    

ccc tac gcg gcc tct cgc gac ttt gac gtg aag tac gtg gtg ccc agc        144
Pro Tyr Ala Ala Ser Arg Asp Phe Asp Val Lys Tyr Val Val Pro Ser           
        35                  40                  45                        

ttc tcc gcc gga ggc ctg gta cag gcc atg gtg acc tac gag ggc gac        192
Phe Ser Ala Gly Gly Leu Val Gln Ala Met Val Thr Tyr Glu Gly Asp           
    50                  55                  60                            

aga aat gag agt gct gtg ttt gta gcc ata cgc aat cgc ctg cat gtg        240
Arg Asn Glu Ser Ala Val Phe Val Ala Ile Arg Asn Arg Leu His Val           
65                  70                  75                  80            

ctt ggg cct gac ctg aag tct gtc cag agc ctg gcc acg ggc cct gct        288
Leu Gly Pro Asp Leu Lys Ser Val Gln Ser Leu Ala Thr Gly Pro Ala           
                85                  90                  95                

gga gac cct ggc tgc cag acg tgt gca gcc tgt ggc cca gga ccc cac        336
Gly Asp Pro Gly Cys Gln Thr Cys Ala Ala Cys Gly Pro Gly Pro His           
            100                 105                 110                   

ggc cct ccc ggt gac aca gac aca aag gtg ctg gtg ctg gat ccc gcg        384
Gly Pro Pro Gly Asp Thr Asp Thr Lys Val Leu Val Leu Asp Pro Ala           
        115                 120                 125                       

ctg cct gcg ctg gtc agt tgt ggc tcc agc ctg cag ggc cgc tgc ttc        432
Leu Pro Ala Leu Val Ser Cys Gly Ser Ser Leu Gln Gly Arg Cys Phe           
    130                 135                 140                           

ctg cat gac cta gag ccc caa ggg aca gcc gtg cat ctg gca gcg cca        480
Leu His Asp Leu Glu Pro Gln Gly Thr Ala Val His Leu Ala Ala Pro           
145                 150                 155                 160           

gcc tgc ctc ttc tca gcc cac cat aac cgg ccc gat gac tgc ccc gac        528
Ala Cys Leu Phe Ser Ala His His Asn Arg Pro Asp Asp Cys Pro Asp           
                165                 170                 175               

tgt gtg gcc agc cca ttg ggc acc cgt gta act gtg gtt gag caa ggc        576
Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln Gly           
            180                 185                 190                   

cag gcc tcc tat ttc tac gtg gca tcc tca ctg gac gca gcc gtg gct        624
Gln Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Ala Ala Val Ala           
        195                 200                 205                       

gcc agc ttc agc cca cgc tca gtg tct atc agg cgt ctc aag gct gac        672
Ala Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ala Asp           
    210                 215                 220                           

gcc tcg gga ttc gca ccg ggc ttt gtg gcg ttg tca gtg ctg ccc aag        720
Ala Ser Gly Phe Ala Pro Gly Phe Val Ala Leu Ser Val Leu Pro Lys           
225                 230                 235                 240           

cat ctt gtc tcc tac agt att gaa tac gtg cac agc ttc cac acg gga        768
His Leu Val Ser Tyr Ser Ile Glu Tyr Val His Ser Phe His Thr Gly           
                245                 250                 255               

gcc ttc gta tac ttc ctg act gta cag ccg gcc agc gtg aca gat gat        816
Ala Phe Val Tyr Phe Leu Thr Val Gln Pro Ala Ser Val Thr Asp Asp           
            260                 265                 270                   

cct agt gcc ctg cac aca cgc ctg gca cgg ctt agc gcc act gag cca        864
Pro Ser Ala Leu His Thr Arg Leu Ala Arg Leu Ser Ala Thr Glu Pro           
        275                 280                 285                       

gag ttg ggt gac tat cgg gag ctg gtc ctc gac tgc aga ttt gct cca        912
Glu Leu Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys Arg Phe Ala Pro           
    290                 295                 300                           

aaa cgc agg cgc cgg ggg gcc cca gaa ggc gga cag ccc tac cct gtg        960
Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Gly Gln Pro Tyr Pro Val           
305                 310                 315                 320           

ctg cgg gtg gcc cac tcc gct cca gtg ggt gcc caa ctt gcc act gag       1008
Leu Arg Val Ala His Ser Ala Pro Val Gly Ala Gln Leu Ala Thr Glu           
                325                 330                 335               

ctg agc atc gcc gag ggc cag gaa gta cta ttt ggg gtc ttt gtg act       1056
Leu Ser Ile Ala Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val Thr           
            340                 345                 350                   

ggc aag gat ggt ggt cct ggc gtg ggc ccc aac tct gtc gtc tgt gcc       1104
Gly Lys Asp Gly Gly Pro Gly Val Gly Pro Asn Ser Val Val Cys Ala           
        355                 360                 365                       

ttc ccc att gac ctg ctg gac aca cta att gat gag ggt gtg gag cgc       1152
Phe Pro Ile Asp Leu Leu Asp Thr Leu Ile Asp Glu Gly Val Glu Arg           
    370                 375                 380                           

tgt tgt gaa tcc cca gtc cat cca ggc ctc cgg cga ggc ctc gac ttc       1200
Cys Cys Glu Ser Pro Val His Pro Gly Leu Arg Arg Gly Leu Asp Phe           
385                 390                 395                 400           

ttc cag tcg ccc agt ttt tgc ccc aac ccg cct ggc ctg gaa gcc ctc       1248
Phe Gln Ser Pro Ser Phe Cys Pro Asn Pro Pro Gly Leu Glu Ala Leu           
                405                 410                 415               

agc ccc aac acc agc tgc cgc cac ttc cct ctg ctg gtc agt agc agc       1296
Ser Pro Asn Thr Ser Cys Arg His Phe Pro Leu Leu Val Ser Ser Ser           
            420                 425                 430                   

ttc tca cgt gtg gac cta ttc aat ggg ctg ttg gga cca gta cag gtc       1344
Phe Ser Arg Val Asp Leu Phe Asn Gly Leu Leu Gly Pro Val Gln Val           
        435                 440                 445                       

act gca ttg tat gtg aca cgc ctt gac aac gtc aca gtg gca cac atg       1392
Thr Ala Leu Tyr Val Thr Arg Leu Asp Asn Val Thr Val Ala His Met           
    450                 455                 460                           

ggc aca atg gat ggg cgt atc ctg cag gtg gag ctg gtc agg tca cta       1440
Gly Thr Met Asp Gly Arg Ile Leu Gln Val Glu Leu Val Arg Ser Leu           
465                 470                 475                 480           

aac tac ttg ctg tat gtg tcc aac ttc tca ctg ggt gac agt ggg cag       1488
Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu Gly Asp Ser Gly Gln           
                485                 490                 495               

ccc gtg cag cgg gat gtc agt cgt ctt ggg gac cac cta ctc ttt gcc       1536
Pro Val Gln Arg Asp Val Ser Arg Leu Gly Asp His Leu Leu Phe Ala           
            500                 505                 510                   

tct ggg gac cag gtt ttc cag gta cct atc caa ggc cct ggc tgc cgc       1584
Ser Gly Asp Gln Val Phe Gln Val Pro Ile Gln Gly Pro Gly Cys Arg           
        515                 520                 525                       

cac ttc ctg acc tgt ggg cgt tgc cta agg gca tgg cat ttc atg ggc       1632
His Phe Leu Thr Cys Gly Arg Cys Leu Arg Ala Trp His Phe Met Gly           
    530                 535                 540                           

tgt ggc tgg tgt ggg aac atg tgc ggc cag cag aag gag tgt cct ggc       1680
Cys Gly Trp Cys Gly Asn Met Cys Gly Gln Gln Lys Glu Cys Pro Gly           
545                 550                 555                 560           

tcc tgg caa cag gac cac tgc cca cct aag ctt act gag ttc cac ccc       1728
Ser Trp Gln Gln Asp His Cys Pro Pro Lys Leu Thr Glu Phe His Pro           
                565                 570                 575               

cac agt gga cct cta agg ggc agt aca agg ctg acc ctg tgt ggc tcc       1776
His Ser Gly Pro Leu Arg Gly Ser Thr Arg Leu Thr Leu Cys Gly Ser           
            580                 585                 590                   

aac ttc tac ctt cac cct tct ggt ctg gtg cct gag gga acc cat cag       1824
Asn Phe Tyr Leu His Pro Ser Gly Leu Val Pro Glu Gly Thr His Gln           
        595                 600                 605                       

gtc act gtg ggc caa agt ccc tgc cgg cca ctg ccc aag gac agc tca       1872
Val Thr Val Gly Gln Ser Pro Cys Arg Pro Leu Pro Lys Asp Ser Ser           
    610                 615                 620                           

aaa ctc aga cca gtg ccc cgg aaa gac ttt gta gag gag ttt gag tgt       1920
Lys Leu Arg Pro Val Pro Arg Lys Asp Phe Val Glu Glu Phe Glu Cys           
625                 630                 635                 640           

gaa ctg gag ccc ttg ggc acc cag gca gtg ggg cct acc aac gtc agc       1968
Glu Leu Glu Pro Leu Gly Thr Gln Ala Val Gly Pro Thr Asn Val Ser           
                645                 650                 655               

ctc acc gtg act aac atg cca ccg ggc aag cac ttc cgg gta gac ggc       2016
Leu Thr Val Thr Asn Met Pro Pro Gly Lys His Phe Arg Val Asp Gly           
            660                 665                 670                   

acc tcc gtg ctg aga ggc ttc tct ttc atg acc ggt cat cat cat cat       2064
Thr Ser Val Leu Arg Gly Phe Ser Phe Met Thr Gly His His His His           
        675                 680                 685                       

cat cat cat cat tga                                                   2079
His His His His                                                           
    690                                                                   


<210>  46
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46

Met Glu Leu Leu Pro Pro Leu Pro Gln Ser Phe Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Ala Lys Pro Ala Ala Gly Glu Asp Trp Gln Cys Pro Arg Thr 
            20                  25                  30          


Pro Tyr Ala Ala Ser Arg Asp Phe Asp Val Lys Tyr Val Val Pro Ser 
        35                  40                  45              


Phe Ser Ala Gly Gly Leu Val Gln Ala Met Val Thr Tyr Glu Gly Asp 
    50                  55                  60                  


Arg Asn Glu Ser Ala Val Phe Val Ala Ile Arg Asn Arg Leu His Val 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Lys Ser Val Gln Ser Leu Ala Thr Gly Pro Ala 
                85                  90                  95      


Gly Asp Pro Gly Cys Gln Thr Cys Ala Ala Cys Gly Pro Gly Pro His 
            100                 105                 110         


Gly Pro Pro Gly Asp Thr Asp Thr Lys Val Leu Val Leu Asp Pro Ala 
        115                 120                 125             


Leu Pro Ala Leu Val Ser Cys Gly Ser Ser Leu Gln Gly Arg Cys Phe 
    130                 135                 140                 


Leu His Asp Leu Glu Pro Gln Gly Thr Ala Val His Leu Ala Ala Pro 
145                 150                 155                 160 


Ala Cys Leu Phe Ser Ala His His Asn Arg Pro Asp Asp Cys Pro Asp 
                165                 170                 175     


Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln Gly 
            180                 185                 190         


Gln Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Ala Ala Val Ala 
        195                 200                 205             


Ala Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ala Asp 
    210                 215                 220                 


Ala Ser Gly Phe Ala Pro Gly Phe Val Ala Leu Ser Val Leu Pro Lys 
225                 230                 235                 240 


His Leu Val Ser Tyr Ser Ile Glu Tyr Val His Ser Phe His Thr Gly 
                245                 250                 255     


Ala Phe Val Tyr Phe Leu Thr Val Gln Pro Ala Ser Val Thr Asp Asp 
            260                 265                 270         


Pro Ser Ala Leu His Thr Arg Leu Ala Arg Leu Ser Ala Thr Glu Pro 
        275                 280                 285             


Glu Leu Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys Arg Phe Ala Pro 
    290                 295                 300                 


Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Gly Gln Pro Tyr Pro Val 
305                 310                 315                 320 


Leu Arg Val Ala His Ser Ala Pro Val Gly Ala Gln Leu Ala Thr Glu 
                325                 330                 335     


Leu Ser Ile Ala Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val Thr 
            340                 345                 350         


Gly Lys Asp Gly Gly Pro Gly Val Gly Pro Asn Ser Val Val Cys Ala 
        355                 360                 365             


Phe Pro Ile Asp Leu Leu Asp Thr Leu Ile Asp Glu Gly Val Glu Arg 
    370                 375                 380                 


Cys Cys Glu Ser Pro Val His Pro Gly Leu Arg Arg Gly Leu Asp Phe 
385                 390                 395                 400 


Phe Gln Ser Pro Ser Phe Cys Pro Asn Pro Pro Gly Leu Glu Ala Leu 
                405                 410                 415     


Ser Pro Asn Thr Ser Cys Arg His Phe Pro Leu Leu Val Ser Ser Ser 
            420                 425                 430         


Phe Ser Arg Val Asp Leu Phe Asn Gly Leu Leu Gly Pro Val Gln Val 
        435                 440                 445             


Thr Ala Leu Tyr Val Thr Arg Leu Asp Asn Val Thr Val Ala His Met 
    450                 455                 460                 


Gly Thr Met Asp Gly Arg Ile Leu Gln Val Glu Leu Val Arg Ser Leu 
465                 470                 475                 480 


Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu Gly Asp Ser Gly Gln 
                485                 490                 495     


Pro Val Gln Arg Asp Val Ser Arg Leu Gly Asp His Leu Leu Phe Ala 
            500                 505                 510         


Ser Gly Asp Gln Val Phe Gln Val Pro Ile Gln Gly Pro Gly Cys Arg 
        515                 520                 525             


His Phe Leu Thr Cys Gly Arg Cys Leu Arg Ala Trp His Phe Met Gly 
    530                 535                 540                 


Cys Gly Trp Cys Gly Asn Met Cys Gly Gln Gln Lys Glu Cys Pro Gly 
545                 550                 555                 560 


Ser Trp Gln Gln Asp His Cys Pro Pro Lys Leu Thr Glu Phe His Pro 
                565                 570                 575     


His Ser Gly Pro Leu Arg Gly Ser Thr Arg Leu Thr Leu Cys Gly Ser 
            580                 585                 590         


Asn Phe Tyr Leu His Pro Ser Gly Leu Val Pro Glu Gly Thr His Gln 
        595                 600                 605             


Val Thr Val Gly Gln Ser Pro Cys Arg Pro Leu Pro Lys Asp Ser Ser 
    610                 615                 620                 


Lys Leu Arg Pro Val Pro Arg Lys Asp Phe Val Glu Glu Phe Glu Cys 
625                 630                 635                 640 


Glu Leu Glu Pro Leu Gly Thr Gln Ala Val Gly Pro Thr Asn Val Ser 
                645                 650                 655     


Leu Thr Val Thr Asn Met Pro Pro Gly Lys His Phe Arg Val Asp Gly 
            660                 665                 670         


Thr Ser Val Leu Arg Gly Phe Ser Phe Met Thr Gly His His His His 
        675                 680                 685             


His His His His 
    690         


<210>  47
<211>  4137
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(4137)

<400>  47
atg ggg ctg cct ctg ccg ctg ctt caa tcc tct ctt ctg cta atg ctt         48
Met Gly Leu Pro Leu Pro Leu Leu Gln Ser Ser Leu Leu Leu Met Leu           
1               5                   10                  15                

ctt ttg cgg ctg tcg gcg gcg tcc acc aac ctg aac tgg cag tgc cca         96
Leu Leu Arg Leu Ser Ala Ala Ser Thr Asn Leu Asn Trp Gln Cys Pro           
            20                  25                  30                    

cga ata ccc tac gca gcc tcc cga gac ttc agt gtc aag tac gtg gtc        144
Arg Ile Pro Tyr Ala Ala Ser Arg Asp Phe Ser Val Lys Tyr Val Val           
        35                  40                  45                        

ccc agc ttc tcc gcg ggg ggc cgg gta cag gcc acc gca gcc tac gag        192
Pro Ser Phe Ser Ala Gly Gly Arg Val Gln Ala Thr Ala Ala Tyr Glu           
    50                  55                  60                            

gac agt aca aat agt gcg gtg ttt gtg gcc aca cgc aat cac ctg cac        240
Asp Ser Thr Asn Ser Ala Val Phe Val Ala Thr Arg Asn His Leu His           
65                  70                  75                  80            

gtg ctt ggg cct gac ctg cag ttc ata gag aac ctg acc act ggc cct        288
Val Leu Gly Pro Asp Leu Gln Phe Ile Glu Asn Leu Thr Thr Gly Pro           
                85                  90                  95                

atc ggg aac cct ggc tgc cag act tgt gcg agc tgt ggt cca ggc cct        336
Ile Gly Asn Pro Gly Cys Gln Thr Cys Ala Ser Cys Gly Pro Gly Pro           
            100                 105                 110                   

cat gga cca cca aag gac aca gac aca ctg gtg cta gtg atg gag cca        384
His Gly Pro Pro Lys Asp Thr Asp Thr Leu Val Leu Val Met Glu Pro           
        115                 120                 125                       

ggt ttg cca gcc ctg gtc agc tgt ggc tca acc cta cag ggc cgc tgc        432
Gly Leu Pro Ala Leu Val Ser Cys Gly Ser Thr Leu Gln Gly Arg Cys           
    130                 135                 140                           

ttc ctg cat gag ctg gag cct cgg ggg aaa gcc ctg cac tta gca gct        480
Phe Leu His Glu Leu Glu Pro Arg Gly Lys Ala Leu His Leu Ala Ala           
145                 150                 155                 160           

cca gcc tgc cta ttc tca gca aac aat aac aag cct gag gcc tgc acg        528
Pro Ala Cys Leu Phe Ser Ala Asn Asn Asn Lys Pro Glu Ala Cys Thr           
                165                 170                 175               

gac tgt gtg gct agc ccc ctg ggc act cgt gtg act gtg gtg gag cag        576
Asp Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln           
            180                 185                 190                   

ggg cat gct tcc tac ttc tat gtg gca tct tcg cta gac cca gag ttg        624
Gly His Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Pro Glu Leu           
        195                 200                 205                       

gcc gct agc ttt agc ccc cgc tcg gtg tcc atc cgt cgt cta aag tct        672
Ala Ala Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ser           
    210                 215                 220                           

gat act tct gga ttc caa cca ggt ttt ccg tcg ctg tcg gtg ctg ccc        720
Asp Thr Ser Gly Phe Gln Pro Gly Phe Pro Ser Leu Ser Val Leu Pro           
225                 230                 235                 240           

aaa tat ttg gcc tcc tac ctc atc aaa tat gtg tac agc ttc cac tcg        768
Lys Tyr Leu Ala Ser Tyr Leu Ile Lys Tyr Val Tyr Ser Phe His Ser           
                245                 250                 255               

ggg gat ttt gtc tac ttt ctg act gtc cag ccc atc agt gtc aca agc        816
Gly Asp Phe Val Tyr Phe Leu Thr Val Gln Pro Ile Ser Val Thr Ser           
            260                 265                 270                   

cct ccc agt gcc ttg cat aca cgt ctg gtc cgg ctc aat gct gta gag        864
Pro Pro Ser Ala Leu His Thr Arg Leu Val Arg Leu Asn Ala Val Glu           
        275                 280                 285                       

cca gag att ggt gac tac cgg gag ctg gtc ttg gac tgt cat ttt gca        912
Pro Glu Ile Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys His Phe Ala           
    290                 295                 300                           

cct aaa cgc cgg cgc cgt gga gcc ccg gag ggc aca cag ccc tac cca        960
Pro Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Thr Gln Pro Tyr Pro           
305                 310                 315                 320           

gtg ctt cag gca gcc cac tct gct cca gtg gat gcc aaa ctg gct gtg       1008
Val Leu Gln Ala Ala His Ser Ala Pro Val Asp Ala Lys Leu Ala Val           
                325                 330                 335               

gaa ctg agc att tca gag ggc cag gaa gtg ctt ttt ggg gtc ttt gtg       1056
Glu Leu Ser Ile Ser Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val           
            340                 345                 350                   

acc gtc aag gat ggt ggc tct ggc atg ggt ccc aac tct gtt gta tgt       1104
Thr Val Lys Asp Gly Gly Ser Gly Met Gly Pro Asn Ser Val Val Cys           
        355                 360                 365                       

gcc ttc ccc att tac cac ctg aac atc ctg att gaa gag ggt gtc gaa       1152
Ala Phe Pro Ile Tyr His Leu Asn Ile Leu Ile Glu Glu Gly Val Glu           
    370                 375                 380                           

tat tgc tgt cac tct tca aat tct tct tcc ctg ttg tcg aga ggc ctt       1200
Tyr Cys Cys His Ser Ser Asn Ser Ser Ser Leu Leu Ser Arg Gly Leu           
385                 390                 395                 400           

gac ttc ttc cag acg ccc agt ttt tgt cct aat ccg cct ggt gga gag       1248
Asp Phe Phe Gln Thr Pro Ser Phe Cys Pro Asn Pro Pro Gly Gly Glu           
                405                 410                 415               

gcc tcc ggc ccc agc tcc cgt tgc cac tac ttc cct ttg atg gtc cac       1296
Ala Ser Gly Pro Ser Ser Arg Cys His Tyr Phe Pro Leu Met Val His           
            420                 425                 430                   

gct agc ttc acc cgt gtg gac ctc ttc aat gga ctg tta gga tca gtg       1344
Ala Ser Phe Thr Arg Val Asp Leu Phe Asn Gly Leu Leu Gly Ser Val           
        435                 440                 445                       

aag gtc acc gca ctg cat gtg aca cgt ctt ggc aat gtt aca gtg gcc       1392
Lys Val Thr Ala Leu His Val Thr Arg Leu Gly Asn Val Thr Val Ala           
    450                 455                 460                           

cac atg ggc act gtg gat ggg cgt gtc cta cag gtg gag ata gcc agg       1440
His Met Gly Thr Val Asp Gly Arg Val Leu Gln Val Glu Ile Ala Arg           
465                 470                 475                 480           

tca ctc aac tac ctg ctg tat gtg tcc aac ttc tcc ctg ggc agc agt       1488
Ser Leu Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu Gly Ser Ser           
                485                 490                 495               

gga cag cct gtt cat cgg gat gtc agc cgc ctc ggg aat gac cta ctc       1536
Gly Gln Pro Val His Arg Asp Val Ser Arg Leu Gly Asn Asp Leu Leu           
            500                 505                 510                   

ttt gcc tct ggg gac cag gtc ttc aag gtg ccc atc cag ggc cct ggc       1584
Phe Ala Ser Gly Asp Gln Val Phe Lys Val Pro Ile Gln Gly Pro Gly           
        515                 520                 525                       

tgt cgt cat ttt ctc acc tgt tgg cgt tgc ctg aga gca cag cgc ttc       1632
Cys Arg His Phe Leu Thr Cys Trp Arg Cys Leu Arg Ala Gln Arg Phe           
    530                 535                 540                           

atg gga tgt ggc tgg tgt ggg gac cgg tgt gac cgg cag aag gag tgt       1680
Met Gly Cys Gly Trp Cys Gly Asp Arg Cys Asp Arg Gln Lys Glu Cys           
545                 550                 555                 560           

cct ggc tcc tgg caa cag gac cac tgt ccg cct gag atc agt gag ttc       1728
Pro Gly Ser Trp Gln Gln Asp His Cys Pro Pro Glu Ile Ser Glu Phe           
                565                 570                 575               

tat cct cac agc ggg cct cta agg ggc act acg agg ctc acc ctt tgt       1776
Tyr Pro His Ser Gly Pro Leu Arg Gly Thr Thr Arg Leu Thr Leu Cys           
            580                 585                 590                   

ggc tcc aac ttc tac ctg cga cct gat gat gtc gta cct gag gga aca       1824
Gly Ser Asn Phe Tyr Leu Arg Pro Asp Asp Val Val Pro Glu Gly Thr           
        595                 600                 605                       

cac cag atc acc gtg ggc caa agt ccc tgc cga ctg ctg cct aag gac       1872
His Gln Ile Thr Val Gly Gln Ser Pro Cys Arg Leu Leu Pro Lys Asp           
    610                 615                 620                           

tct tca agc cct agg cca ggg tcc ctc aag gaa ttc ata cag gaa ctt       1920
Ser Ser Ser Pro Arg Pro Gly Ser Leu Lys Glu Phe Ile Gln Glu Leu           
625                 630                 635                 640           

gaa tgt gag ctg gag ccc ctg gtc acc cag gca gtg ggg act aca aac       1968
Glu Cys Glu Leu Glu Pro Leu Val Thr Gln Ala Val Gly Thr Thr Asn           
                645                 650                 655               

atc agc ctt gtc atc acc aac atg cca gca ggc aag cac ttc cga gtg       2016
Ile Ser Leu Val Ile Thr Asn Met Pro Ala Gly Lys His Phe Arg Val           
            660                 665                 670                   

gaa ggc atc tct gta cag gaa ggc ttc tct ttc gtg gag cca gtg ctg       2064
Glu Gly Ile Ser Val Gln Glu Gly Phe Ser Phe Val Glu Pro Val Leu           
        675                 680                 685                       

aca tca ata aaa cct gac ttt ggc ccg cgg gct ggg ggt act tat ctc       2112
Thr Ser Ile Lys Pro Asp Phe Gly Pro Arg Ala Gly Gly Thr Tyr Leu           
    690                 695                 700                           

acc ctt gaa ggc cag agc ctg tct gtc ggc acc agc cgg gct gtg ctg       2160
Thr Leu Glu Gly Gln Ser Leu Ser Val Gly Thr Ser Arg Ala Val Leu           
705                 710                 715                 720           

gtc aat gga acc cag tgc cgg ctg gaa cag gtc aat gag gag cag atc       2208
Val Asn Gly Thr Gln Cys Arg Leu Glu Gln Val Asn Glu Glu Gln Ile           
                725                 730                 735               

tta tgt gtc acg cct cct gga gct ggc acg gcc agg gtc ccc ctt cat       2256
Leu Cys Val Thr Pro Pro Gly Ala Gly Thr Ala Arg Val Pro Leu His           
            740                 745                 750                   

ctg cag ata ggg ggt gct gag gtg cct ggc tcc tgg acc ttt cac tac       2304
Leu Gln Ile Gly Gly Ala Glu Val Pro Gly Ser Trp Thr Phe His Tyr           
        755                 760                 765                       

aag gaa gac cct att gtg ttg gac atc agt ccc aag tgt ggc tac agt       2352
Lys Glu Asp Pro Ile Val Leu Asp Ile Ser Pro Lys Cys Gly Tyr Ser           
    770                 775                 780                           

ggc tcc cac atc atg atc cat ggc cag cat ctg act tca gca tgg cac       2400
Gly Ser His Ile Met Ile His Gly Gln His Leu Thr Ser Ala Trp His           
785                 790                 795                 800           

ttc acg cta tca ttc cat gat gga caa agt aca gtg gag agc agg tgt       2448
Phe Thr Leu Ser Phe His Asp Gly Gln Ser Thr Val Glu Ser Arg Cys           
                805                 810                 815               

gcg ggg cag ttt gtg gaa caa cag cag cgt cga tgt cgc ctg cct gaa       2496
Ala Gly Gln Phe Val Glu Gln Gln Gln Arg Arg Cys Arg Leu Pro Glu           
            820                 825                 830                   

tat gtg gtc cga aac cct cag ggg tgg gca aca ggg aat ctg agc gtc       2544
Tyr Val Val Arg Asn Pro Gln Gly Trp Ala Thr Gly Asn Leu Ser Val           
        835                 840                 845                       

tgg ggt gat gga gca gct ggc ttc acg ctg cct ggt ttt cgc ttc ctg       2592
Trp Gly Asp Gly Ala Ala Gly Phe Thr Leu Pro Gly Phe Arg Phe Leu           
    850                 855                 860                           

ccc cca ccc agt cca ctc aga gct ggc ctg gtt gag ttg aaa cct gaa       2640
Pro Pro Pro Ser Pro Leu Arg Ala Gly Leu Val Glu Leu Lys Pro Glu           
865                 870                 875                 880           

gaa cat tca gtt aaa gtt gag tat gtc ggg ctg ggc gct gtg gca gac       2688
Glu His Ser Val Lys Val Glu Tyr Val Gly Leu Gly Ala Val Ala Asp           
                885                 890                 895               

tgt gtg act gtg aac atg acc gtg ggt ggt gag gtc tgc caa cat gag       2736
Cys Val Thr Val Asn Met Thr Val Gly Gly Glu Val Cys Gln His Glu           
            900                 905                 910                   

ctc cgg ggg gat gtg gtg atc tgc ccc ctg ccc cct tcc ctg caa ctt       2784
Leu Arg Gly Asp Val Val Ile Cys Pro Leu Pro Pro Ser Leu Gln Leu           
        915                 920                 925                       

ggc aag gat ggt gtc cca ttg cag gtc tgt gta gac ggt ggg tgt cac       2832
Gly Lys Asp Gly Val Pro Leu Gln Val Cys Val Asp Gly Gly Cys His           
    930                 935                 940                           

atc ctg agc caa gtg gtt cgc tca agc cca ggc agg gcc tca cag agg       2880
Ile Leu Ser Gln Val Val Arg Ser Ser Pro Gly Arg Ala Ser Gln Arg           
945                 950                 955                 960           

ata ctc ctt att gct ctt ctg gtc ttg atc ctg ctt gtg gct gtg ctg       2928
Ile Leu Leu Ile Ala Leu Leu Val Leu Ile Leu Leu Val Ala Val Leu           
                965                 970                 975               

gcc gtt gcc ctg atc ttt aac tcc cga aga cgg aaa aag cag cta ggt       2976
Ala Val Ala Leu Ile Phe Asn Ser Arg Arg Arg Lys Lys Gln Leu Gly           
            980                 985                 990                   

gct cac tcc ctc tcc cca aca aca  ctc tct gac atc aac  gat aca gct     3024
Ala His Ser Leu Ser Pro Thr Thr  Leu Ser Asp Ile Asn  Asp Thr Ala         
        995                 1000                 1005                     

tcc ggg  gct ccg aac cat gaa  gaa tcg tca gag agt  agg gat ggg        3069
Ser Gly  Ala Pro Asn His Glu  Glu Ser Ser Glu Ser  Arg Asp Gly            
    1010                 1015                 1020                        

aca agt  gtc cca ctg ctg cgg  aca gag tct atc cgg  ctc cag gat        3114
Thr Ser  Val Pro Leu Leu Arg  Thr Glu Ser Ile Arg  Leu Gln Asp            
    1025                 1030                 1035                        

ctg gac  agg atg ctc cta gct  gag gtc aag gat gta  ctg att ccc        3159
Leu Asp  Arg Met Leu Leu Ala  Glu Val Lys Asp Val  Leu Ile Pro            
    1040                 1045                 1050                        

cat gaa  caa gtg gtc atc cat  act gac caa gtc att  ggc aaa ggc        3204
His Glu  Gln Val Val Ile His  Thr Asp Gln Val Ile  Gly Lys Gly            
    1055                 1060                 1065                        

cac ttt  ggt gtt gtc tac cac  gga gaa tat aca gac  gga gca cag        3249
His Phe  Gly Val Val Tyr His  Gly Glu Tyr Thr Asp  Gly Ala Gln            
    1070                 1075                 1080                        

aat cag  acc cac tgt gcc atc  aag tct ctg agt cgc  att aca gag        3294
Asn Gln  Thr His Cys Ala Ile  Lys Ser Leu Ser Arg  Ile Thr Glu            
    1085                 1090                 1095                        

gtg cag  gag gtg gag gct ttc  ctg cgg gag ggg ctg  ctc atg cgt        3339
Val Gln  Glu Val Glu Ala Phe  Leu Arg Glu Gly Leu  Leu Met Arg            
    1100                 1105                 1110                        

ggc cta  cat cac cca aac atc  ctg gct ctc atc ggt  atc atg ctg        3384
Gly Leu  His His Pro Asn Ile  Leu Ala Leu Ile Gly  Ile Met Leu            
    1115                 1120                 1125                        

ccc ccg  gag ggg ctt ccc cgg  gtg ctg ttg ccc tat  atg cgc cac        3429
Pro Pro  Glu Gly Leu Pro Arg  Val Leu Leu Pro Tyr  Met Arg His            
    1130                 1135                 1140                        

gga gac  ctg ctt cat ttc att  cgc tcc cct cag agg  aac ccc act        3474
Gly Asp  Leu Leu His Phe Ile  Arg Ser Pro Gln Arg  Asn Pro Thr            
    1145                 1150                 1155                        

gtg aag  gat ctt gtc agc ttt  ggc ctg cag gta gcc  tgt ggt atg        3519
Val Lys  Asp Leu Val Ser Phe  Gly Leu Gln Val Ala  Cys Gly Met            
    1160                 1165                 1170                        

gag tac  ctg gca gag cag aag  ttc gtg cac aga gac  ctg gct gct        3564
Glu Tyr  Leu Ala Glu Gln Lys  Phe Val His Arg Asp  Leu Ala Ala            
    1175                 1180                 1185                        

agg aac  tgc atg ctg gac gag  tca ttc aca gtc aag  gtg gct gac        3609
Arg Asn  Cys Met Leu Asp Glu  Ser Phe Thr Val Lys  Val Ala Asp            
    1190                 1195                 1200                        

ttt ggt  ctg gca cgg ggc gtc  cta gac aag gaa tac  tac agt gtt        3654
Phe Gly  Leu Ala Arg Gly Val  Leu Asp Lys Glu Tyr  Tyr Ser Val            
    1205                 1210                 1215                        

cgc cag  cat cgc cat gct cgc  ctg cca gtc aaa tgg  atg gca ctg        3699
Arg Gln  His Arg His Ala Arg  Leu Pro Val Lys Trp  Met Ala Leu            
    1220                 1225                 1230                        

gag agc  ctg cag acc tac agg  ttc acc acc aag tcc  gat gtg tgg        3744
Glu Ser  Leu Gln Thr Tyr Arg  Phe Thr Thr Lys Ser  Asp Val Trp            
    1235                 1240                 1245                        

tca ttc  ggg gtg ctg ctc tgg  gag cta cta aca cgg  ggt gct cca        3789
Ser Phe  Gly Val Leu Leu Trp  Glu Leu Leu Thr Arg  Gly Ala Pro            
    1250                 1255                 1260                        

ccc tac  ccc cat atc gat ccc  ttc gac ctc tct cac  ttc ctg gct        3834
Pro Tyr  Pro His Ile Asp Pro  Phe Asp Leu Ser His  Phe Leu Ala            
    1265                 1270                 1275                        

cag ggc  cgt cgc ctg cct cag  cct gag tac tgt cct  gat tca ctg        3879
Gln Gly  Arg Arg Leu Pro Gln  Pro Glu Tyr Cys Pro  Asp Ser Leu            
    1280                 1285                 1290                        

tat cac  gtg atg ctt cga tgc  tgg gag gct gac cca  gcg gca cga        3924
Tyr His  Val Met Leu Arg Cys  Trp Glu Ala Asp Pro  Ala Ala Arg            
    1295                 1300                 1305                        

ccc acc  ttc aga gcc cta gtg  ctg gaa gta aag cag  gta gtg gcc        3969
Pro Thr  Phe Arg Ala Leu Val  Leu Glu Val Lys Gln  Val Val Ala            
    1310                 1315                 1320                        

tca ctg  ctt ggg gac cac tat  gtg cag ctg aca gca  gct tat gtg        4014
Ser Leu  Leu Gly Asp His Tyr  Val Gln Leu Thr Ala  Ala Tyr Val            
    1325                 1330                 1335                        

aac gta  ggc ccc aga gcg gtg  gat gat ggg agt gtg  cct ccg gag        4059
Asn Val  Gly Pro Arg Ala Val  Asp Asp Gly Ser Val  Pro Pro Glu            
    1340                 1345                 1350                        

cag gta  cag ccc tcg cct cag  cat tgc agg agc acg  tca aag ccc        4104
Gln Val  Gln Pro Ser Pro Gln  His Cys Arg Ser Thr  Ser Lys Pro            
    1355                 1360                 1365                        

cgg cct  ctc tca gag cca ccc  ctg ccc act tga                         4137
Arg Pro  Leu Ser Glu Pro Pro  Leu Pro Thr                                 
    1370                 1375                                             


<210>  48
<211>  1378
<212>  PRT
<213>  Mus musculus

<400>  48

Met Gly Leu Pro Leu Pro Leu Leu Gln Ser Ser Leu Leu Leu Met Leu 
1               5                   10                  15      


Leu Leu Arg Leu Ser Ala Ala Ser Thr Asn Leu Asn Trp Gln Cys Pro 
            20                  25                  30          


Arg Ile Pro Tyr Ala Ala Ser Arg Asp Phe Ser Val Lys Tyr Val Val 
        35                  40                  45              


Pro Ser Phe Ser Ala Gly Gly Arg Val Gln Ala Thr Ala Ala Tyr Glu 
    50                  55                  60                  


Asp Ser Thr Asn Ser Ala Val Phe Val Ala Thr Arg Asn His Leu His 
65                  70                  75                  80  


Val Leu Gly Pro Asp Leu Gln Phe Ile Glu Asn Leu Thr Thr Gly Pro 
                85                  90                  95      


Ile Gly Asn Pro Gly Cys Gln Thr Cys Ala Ser Cys Gly Pro Gly Pro 
            100                 105                 110         


His Gly Pro Pro Lys Asp Thr Asp Thr Leu Val Leu Val Met Glu Pro 
        115                 120                 125             


Gly Leu Pro Ala Leu Val Ser Cys Gly Ser Thr Leu Gln Gly Arg Cys 
    130                 135                 140                 


Phe Leu His Glu Leu Glu Pro Arg Gly Lys Ala Leu His Leu Ala Ala 
145                 150                 155                 160 


Pro Ala Cys Leu Phe Ser Ala Asn Asn Asn Lys Pro Glu Ala Cys Thr 
                165                 170                 175     


Asp Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln 
            180                 185                 190         


Gly His Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Pro Glu Leu 
        195                 200                 205             


Ala Ala Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ser 
    210                 215                 220                 


Asp Thr Ser Gly Phe Gln Pro Gly Phe Pro Ser Leu Ser Val Leu Pro 
225                 230                 235                 240 


Lys Tyr Leu Ala Ser Tyr Leu Ile Lys Tyr Val Tyr Ser Phe His Ser 
                245                 250                 255     


Gly Asp Phe Val Tyr Phe Leu Thr Val Gln Pro Ile Ser Val Thr Ser 
            260                 265                 270         


Pro Pro Ser Ala Leu His Thr Arg Leu Val Arg Leu Asn Ala Val Glu 
        275                 280                 285             


Pro Glu Ile Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys His Phe Ala 
    290                 295                 300                 


Pro Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Thr Gln Pro Tyr Pro 
305                 310                 315                 320 


Val Leu Gln Ala Ala His Ser Ala Pro Val Asp Ala Lys Leu Ala Val 
                325                 330                 335     


Glu Leu Ser Ile Ser Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val 
            340                 345                 350         


Thr Val Lys Asp Gly Gly Ser Gly Met Gly Pro Asn Ser Val Val Cys 
        355                 360                 365             


Ala Phe Pro Ile Tyr His Leu Asn Ile Leu Ile Glu Glu Gly Val Glu 
    370                 375                 380                 


Tyr Cys Cys His Ser Ser Asn Ser Ser Ser Leu Leu Ser Arg Gly Leu 
385                 390                 395                 400 


Asp Phe Phe Gln Thr Pro Ser Phe Cys Pro Asn Pro Pro Gly Gly Glu 
                405                 410                 415     


Ala Ser Gly Pro Ser Ser Arg Cys His Tyr Phe Pro Leu Met Val His 
            420                 425                 430         


Ala Ser Phe Thr Arg Val Asp Leu Phe Asn Gly Leu Leu Gly Ser Val 
        435                 440                 445             


Lys Val Thr Ala Leu His Val Thr Arg Leu Gly Asn Val Thr Val Ala 
    450                 455                 460                 


His Met Gly Thr Val Asp Gly Arg Val Leu Gln Val Glu Ile Ala Arg 
465                 470                 475                 480 


Ser Leu Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu Gly Ser Ser 
                485                 490                 495     


Gly Gln Pro Val His Arg Asp Val Ser Arg Leu Gly Asn Asp Leu Leu 
            500                 505                 510         


Phe Ala Ser Gly Asp Gln Val Phe Lys Val Pro Ile Gln Gly Pro Gly 
        515                 520                 525             


Cys Arg His Phe Leu Thr Cys Trp Arg Cys Leu Arg Ala Gln Arg Phe 
    530                 535                 540                 


Met Gly Cys Gly Trp Cys Gly Asp Arg Cys Asp Arg Gln Lys Glu Cys 
545                 550                 555                 560 


Pro Gly Ser Trp Gln Gln Asp His Cys Pro Pro Glu Ile Ser Glu Phe 
                565                 570                 575     


Tyr Pro His Ser Gly Pro Leu Arg Gly Thr Thr Arg Leu Thr Leu Cys 
            580                 585                 590         


Gly Ser Asn Phe Tyr Leu Arg Pro Asp Asp Val Val Pro Glu Gly Thr 
        595                 600                 605             


His Gln Ile Thr Val Gly Gln Ser Pro Cys Arg Leu Leu Pro Lys Asp 
    610                 615                 620                 


Ser Ser Ser Pro Arg Pro Gly Ser Leu Lys Glu Phe Ile Gln Glu Leu 
625                 630                 635                 640 


Glu Cys Glu Leu Glu Pro Leu Val Thr Gln Ala Val Gly Thr Thr Asn 
                645                 650                 655     


Ile Ser Leu Val Ile Thr Asn Met Pro Ala Gly Lys His Phe Arg Val 
            660                 665                 670         


Glu Gly Ile Ser Val Gln Glu Gly Phe Ser Phe Val Glu Pro Val Leu 
        675                 680                 685             


Thr Ser Ile Lys Pro Asp Phe Gly Pro Arg Ala Gly Gly Thr Tyr Leu 
    690                 695                 700                 


Thr Leu Glu Gly Gln Ser Leu Ser Val Gly Thr Ser Arg Ala Val Leu 
705                 710                 715                 720 


Val Asn Gly Thr Gln Cys Arg Leu Glu Gln Val Asn Glu Glu Gln Ile 
                725                 730                 735     


Leu Cys Val Thr Pro Pro Gly Ala Gly Thr Ala Arg Val Pro Leu His 
            740                 745                 750         


Leu Gln Ile Gly Gly Ala Glu Val Pro Gly Ser Trp Thr Phe His Tyr 
        755                 760                 765             


Lys Glu Asp Pro Ile Val Leu Asp Ile Ser Pro Lys Cys Gly Tyr Ser 
    770                 775                 780                 


Gly Ser His Ile Met Ile His Gly Gln His Leu Thr Ser Ala Trp His 
785                 790                 795                 800 


Phe Thr Leu Ser Phe His Asp Gly Gln Ser Thr Val Glu Ser Arg Cys 
                805                 810                 815     


Ala Gly Gln Phe Val Glu Gln Gln Gln Arg Arg Cys Arg Leu Pro Glu 
            820                 825                 830         


Tyr Val Val Arg Asn Pro Gln Gly Trp Ala Thr Gly Asn Leu Ser Val 
        835                 840                 845             


Trp Gly Asp Gly Ala Ala Gly Phe Thr Leu Pro Gly Phe Arg Phe Leu 
    850                 855                 860                 


Pro Pro Pro Ser Pro Leu Arg Ala Gly Leu Val Glu Leu Lys Pro Glu 
865                 870                 875                 880 


Glu His Ser Val Lys Val Glu Tyr Val Gly Leu Gly Ala Val Ala Asp 
                885                 890                 895     


Cys Val Thr Val Asn Met Thr Val Gly Gly Glu Val Cys Gln His Glu 
            900                 905                 910         


Leu Arg Gly Asp Val Val Ile Cys Pro Leu Pro Pro Ser Leu Gln Leu 
        915                 920                 925             


Gly Lys Asp Gly Val Pro Leu Gln Val Cys Val Asp Gly Gly Cys His 
    930                 935                 940                 


Ile Leu Ser Gln Val Val Arg Ser Ser Pro Gly Arg Ala Ser Gln Arg 
945                 950                 955                 960 


Ile Leu Leu Ile Ala Leu Leu Val Leu Ile Leu Leu Val Ala Val Leu 
                965                 970                 975     


Ala Val Ala Leu Ile Phe Asn Ser Arg Arg Arg Lys Lys Gln Leu Gly 
            980                 985                 990         


Ala His Ser Leu Ser Pro Thr Thr  Leu Ser Asp Ile Asn  Asp Thr Ala 
        995                 1000                 1005             


Ser Gly  Ala Pro Asn His Glu  Glu Ser Ser Glu Ser  Arg Asp Gly 
    1010                 1015                 1020             


Thr Ser  Val Pro Leu Leu Arg  Thr Glu Ser Ile Arg  Leu Gln Asp 
    1025                 1030                 1035             


Leu Asp  Arg Met Leu Leu Ala  Glu Val Lys Asp Val  Leu Ile Pro 
    1040                 1045                 1050             


His Glu  Gln Val Val Ile His  Thr Asp Gln Val Ile  Gly Lys Gly 
    1055                 1060                 1065             


His Phe  Gly Val Val Tyr His  Gly Glu Tyr Thr Asp  Gly Ala Gln 
    1070                 1075                 1080             


Asn Gln  Thr His Cys Ala Ile  Lys Ser Leu Ser Arg  Ile Thr Glu 
    1085                 1090                 1095             


Val Gln  Glu Val Glu Ala Phe  Leu Arg Glu Gly Leu  Leu Met Arg 
    1100                 1105                 1110             


Gly Leu  His His Pro Asn Ile  Leu Ala Leu Ile Gly  Ile Met Leu 
    1115                 1120                 1125             


Pro Pro  Glu Gly Leu Pro Arg  Val Leu Leu Pro Tyr  Met Arg His 
    1130                 1135                 1140             


Gly Asp  Leu Leu His Phe Ile  Arg Ser Pro Gln Arg  Asn Pro Thr 
    1145                 1150                 1155             


Val Lys  Asp Leu Val Ser Phe  Gly Leu Gln Val Ala  Cys Gly Met 
    1160                 1165                 1170             


Glu Tyr  Leu Ala Glu Gln Lys  Phe Val His Arg Asp  Leu Ala Ala 
    1175                 1180                 1185             


Arg Asn  Cys Met Leu Asp Glu  Ser Phe Thr Val Lys  Val Ala Asp 
    1190                 1195                 1200             


Phe Gly  Leu Ala Arg Gly Val  Leu Asp Lys Glu Tyr  Tyr Ser Val 
    1205                 1210                 1215             


Arg Gln  His Arg His Ala Arg  Leu Pro Val Lys Trp  Met Ala Leu 
    1220                 1225                 1230             


Glu Ser  Leu Gln Thr Tyr Arg  Phe Thr Thr Lys Ser  Asp Val Trp 
    1235                 1240                 1245             


Ser Phe  Gly Val Leu Leu Trp  Glu Leu Leu Thr Arg  Gly Ala Pro 
    1250                 1255                 1260             


Pro Tyr  Pro His Ile Asp Pro  Phe Asp Leu Ser His  Phe Leu Ala 
    1265                 1270                 1275             


Gln Gly  Arg Arg Leu Pro Gln  Pro Glu Tyr Cys Pro  Asp Ser Leu 
    1280                 1285                 1290             


Tyr His  Val Met Leu Arg Cys  Trp Glu Ala Asp Pro  Ala Ala Arg 
    1295                 1300                 1305             


Pro Thr  Phe Arg Ala Leu Val  Leu Glu Val Lys Gln  Val Val Ala 
    1310                 1315                 1320             


Ser Leu  Leu Gly Asp His Tyr  Val Gln Leu Thr Ala  Ala Tyr Val 
    1325                 1330                 1335             


Asn Val  Gly Pro Arg Ala Val  Asp Asp Gly Ser Val  Pro Pro Glu 
    1340                 1345                 1350             


Gln Val  Gln Pro Ser Pro Gln  His Cys Arg Ser Thr  Ser Lys Pro 
    1355                 1360                 1365             


Arg Pro  Leu Ser Glu Pro Pro  Leu Pro Thr 
    1370                 1375             


<210>  49
<211>  2751
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(2751)

<400>  49
atg ggg ctg cct ctg ccg ctg ctt caa tcc tct ctt ctg cta atg ctt         48
Met Gly Leu Pro Leu Pro Leu Leu Gln Ser Ser Leu Leu Leu Met Leu           
1               5                   10                  15                

ctt ttg cgg ctg tcg gcg gcg tcc acc aac ctg aac tgg cag tgc cca         96
Leu Leu Arg Leu Ser Ala Ala Ser Thr Asn Leu Asn Trp Gln Cys Pro           
            20                  25                  30                    

cga ata ccc tac gca gcc tcc cga gac ttc agt gtc aag tac gtg gtc        144
Arg Ile Pro Tyr Ala Ala Ser Arg Asp Phe Ser Val Lys Tyr Val Val           
        35                  40                  45                        

ccc agc ttc tcc gcg ggg ggc cgg gta cag gcc acc gca gcc tac gag        192
Pro Ser Phe Ser Ala Gly Gly Arg Val Gln Ala Thr Ala Ala Tyr Glu           
    50                  55                  60                            

gac agt aca aat agt gcg gtg ttt gtg gcc aca cgc aat cac ctg cac        240
Asp Ser Thr Asn Ser Ala Val Phe Val Ala Thr Arg Asn His Leu His           
65                  70                  75                  80            

gtg ctt ggg cct gac ctg cag ttc ata gag aac ctg acc act ggc cct        288
Val Leu Gly Pro Asp Leu Gln Phe Ile Glu Asn Leu Thr Thr Gly Pro           
                85                  90                  95                

atc ggg aac cct ggc tgc cag act tgt gcg agc tgt ggt cca ggc cct        336
Ile Gly Asn Pro Gly Cys Gln Thr Cys Ala Ser Cys Gly Pro Gly Pro           
            100                 105                 110                   

cat gga cca cca aag gac aca gac aca ctg gtg cta gtg atg gag cca        384
His Gly Pro Pro Lys Asp Thr Asp Thr Leu Val Leu Val Met Glu Pro           
        115                 120                 125                       

ggt ttg cca gcc ctg gtc agc tgt ggc tca acc cta cag ggc cgc tgc        432
Gly Leu Pro Ala Leu Val Ser Cys Gly Ser Thr Leu Gln Gly Arg Cys           
    130                 135                 140                           

ttc ctg cat gag ctg gag cct cgg ggg aaa gcc ctg cac tta gca gct        480
Phe Leu His Glu Leu Glu Pro Arg Gly Lys Ala Leu His Leu Ala Ala           
145                 150                 155                 160           

cca gcc tgc cta ttc tca gca aac aat aac aag cct gag gcc tgc acg        528
Pro Ala Cys Leu Phe Ser Ala Asn Asn Asn Lys Pro Glu Ala Cys Thr           
                165                 170                 175               

gac tgt gtg gct agc ccc ctg ggc act cgt gtg act gtg gtg gag cag        576
Asp Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln           
            180                 185                 190                   

ggg cat gct tcc tac ttc tat gtg gca tct tcg cta gac cca gag ttg        624
Gly His Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Pro Glu Leu           
        195                 200                 205                       

gcc gct agc ttt agc ccc cgc tcg gtg tcc atc cgt cgt cta aag tct        672
Ala Ala Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ser           
    210                 215                 220                           

gat act tct gga ttc caa cca ggt ttt ccg tcg ctg tcg gtg ctg ccc        720
Asp Thr Ser Gly Phe Gln Pro Gly Phe Pro Ser Leu Ser Val Leu Pro           
225                 230                 235                 240           

aaa tat ttg gcc tcc tac ctc atc aaa tat gtg tac agc ttc cac tcg        768
Lys Tyr Leu Ala Ser Tyr Leu Ile Lys Tyr Val Tyr Ser Phe His Ser           
                245                 250                 255               

ggg gat ttt gtc tac ttt ctg act gtc cag ccc atc agt gtc aca agc        816
Gly Asp Phe Val Tyr Phe Leu Thr Val Gln Pro Ile Ser Val Thr Ser           
            260                 265                 270                   

cct ccc agt gcc ttg cat aca cgt ctg gtc cgg ctc aat gct gta gag        864
Pro Pro Ser Ala Leu His Thr Arg Leu Val Arg Leu Asn Ala Val Glu           
        275                 280                 285                       

cca gag att ggt gac tac cgg gag ctg gtc ttg gac tgt cat ttt gca        912
Pro Glu Ile Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys His Phe Ala           
    290                 295                 300                           

cct aaa cgc cgg cgc cgt gga gcc ccg gag ggc aca cag ccc tac cca        960
Pro Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Thr Gln Pro Tyr Pro           
305                 310                 315                 320           

gtg ctt cag gca gcc cac tct gct cca gtg gat gcc aaa ctg gct gtg       1008
Val Leu Gln Ala Ala His Ser Ala Pro Val Asp Ala Lys Leu Ala Val           
                325                 330                 335               

gaa ctg agc att tca gag ggc cag gaa gtg ctt ttt ggg gtc ttt gtg       1056
Glu Leu Ser Ile Ser Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val           
            340                 345                 350                   

acc gtc aag gat ggt ggc tct ggc atg ggt ccc aac tct gtt gta tgt       1104
Thr Val Lys Asp Gly Gly Ser Gly Met Gly Pro Asn Ser Val Val Cys           
        355                 360                 365                       

gcc ttc ccc att tac cac ctg aac atc ctg att gaa gag ggt gtc gaa       1152
Ala Phe Pro Ile Tyr His Leu Asn Ile Leu Ile Glu Glu Gly Val Glu           
    370                 375                 380                           

tat tgc tgt cac tct tca aat tct tct tcc ctg ttg tcg aga ggc ctt       1200
Tyr Cys Cys His Ser Ser Asn Ser Ser Ser Leu Leu Ser Arg Gly Leu           
385                 390                 395                 400           

gac ttc ttc cag acg ccc agt ttt tgt cct aat ccg cct ggt gga gag       1248
Asp Phe Phe Gln Thr Pro Ser Phe Cys Pro Asn Pro Pro Gly Gly Glu           
                405                 410                 415               

gcc tcc ggc ccc agc tcc cgt tgc cac tac ttc cct ttg atg gtc cac       1296
Ala Ser Gly Pro Ser Ser Arg Cys His Tyr Phe Pro Leu Met Val His           
            420                 425                 430                   

gct agc ttc acc cgt gtg gac ctc ttc aat gga ctg tta gga tca gtg       1344
Ala Ser Phe Thr Arg Val Asp Leu Phe Asn Gly Leu Leu Gly Ser Val           
        435                 440                 445                       

aag gtc acc gca ctg cat gtg aca cgt ctt ggc aat gtt aca gtg gcc       1392
Lys Val Thr Ala Leu His Val Thr Arg Leu Gly Asn Val Thr Val Ala           
    450                 455                 460                           

cac atg ggc act gtg gat ggg cgt gtc cta cag gtg gag ata gcc agg       1440
His Met Gly Thr Val Asp Gly Arg Val Leu Gln Val Glu Ile Ala Arg           
465                 470                 475                 480           

tca ctc aac tac ctg ctg tat gtg tcc aac ttc tcc ctg ggc agc agt       1488
Ser Leu Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu Gly Ser Ser           
                485                 490                 495               

gga cag cct gtt cat cgg gat gtc agc cgc ctc ggg aat gac cta ctc       1536
Gly Gln Pro Val His Arg Asp Val Ser Arg Leu Gly Asn Asp Leu Leu           
            500                 505                 510                   

ttt gcc tct ggg gac cag gtc ttc aag gtg ccc atc cag ggc cct ggc       1584
Phe Ala Ser Gly Asp Gln Val Phe Lys Val Pro Ile Gln Gly Pro Gly           
        515                 520                 525                       

tgt cgt cat ttt ctc acc tgt tgg cgt tgc ctg aga gca cag cgc ttc       1632
Cys Arg His Phe Leu Thr Cys Trp Arg Cys Leu Arg Ala Gln Arg Phe           
    530                 535                 540                           

atg gga tgt ggc tgg tgt ggg gac cgg tgt gac cgg cag aag gag tgt       1680
Met Gly Cys Gly Trp Cys Gly Asp Arg Cys Asp Arg Gln Lys Glu Cys           
545                 550                 555                 560           

cct ggc tcc tgg caa cag gac cac tgt ccg cct gag atc agt gag ttc       1728
Pro Gly Ser Trp Gln Gln Asp His Cys Pro Pro Glu Ile Ser Glu Phe           
                565                 570                 575               

tat cct cac agc ggg cct cta agg ggc act acg agg ctc acc ctt tgt       1776
Tyr Pro His Ser Gly Pro Leu Arg Gly Thr Thr Arg Leu Thr Leu Cys           
            580                 585                 590                   

ggc tcc aac ttc tac ctg cga cct gat gat gtc gta cct gag gga aca       1824
Gly Ser Asn Phe Tyr Leu Arg Pro Asp Asp Val Val Pro Glu Gly Thr           
        595                 600                 605                       

cac cag atc acc gtg ggc caa agt ccc tgc cga ctg ctg cct aag gac       1872
His Gln Ile Thr Val Gly Gln Ser Pro Cys Arg Leu Leu Pro Lys Asp           
    610                 615                 620                           

tct tca agc cct agg cca ggg tcc ctc aag gaa ttc ata cag gaa ctt       1920
Ser Ser Ser Pro Arg Pro Gly Ser Leu Lys Glu Phe Ile Gln Glu Leu           
625                 630                 635                 640           

gaa tgt gag ctg gag ccc ctg gtc acc cag gca gtg ggg act aca aac       1968
Glu Cys Glu Leu Glu Pro Leu Val Thr Gln Ala Val Gly Thr Thr Asn           
                645                 650                 655               

atc agc ctt gtc atc acc aac atg cca gca ggc aag cac ttc cga gtg       2016
Ile Ser Leu Val Ile Thr Asn Met Pro Ala Gly Lys His Phe Arg Val           
            660                 665                 670                   

gaa ggc atc tct gta cag gaa ggc ttc tct ttc ggg cgc gcc cag gtc       2064
Glu Gly Ile Ser Val Gln Glu Gly Phe Ser Phe Gly Arg Ala Gln Val           
        675                 680                 685                       

acc gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa ctc ctg       2112
Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu           
    690                 695                 700                           

ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc       2160
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu           
705                 710                 715                 720           

atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc       2208
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser           
                725                 730                 735               

cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag       2256
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu           
            740                 745                 750                   

gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac agc acg       2304
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr           
        755                 760                 765                       

tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat       2352
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn           
    770                 775                 780                           

ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca gcc ccc       2400
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro           
785                 790                 795                 800           

atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag       2448
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln           
                805                 810                 815               

gtg tac acc ctg ccc cca tcc cgg gaa gag atg acc aag aac cag gtc       2496
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val           
            820                 825                 830                   

agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg       2544
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val           
        835                 840                 845                       

gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc acg cct       2592
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro           
    850                 855                 860                           

ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc       2640
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr           
865                 870                 875                 880           

gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg       2688
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val           
                885                 890                 895               

atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg       2736
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu           
            900                 905                 910                   

tct ccg ggt aaa tga                                                   2751
Ser Pro Gly Lys                                                           
        915                                                               


<210>  50
<211>  916
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50

Met Gly Leu Pro Leu Pro Leu Leu Gln Ser Ser Leu Leu Leu Met Leu 
1               5                   10                  15      


Leu Leu Arg Leu Ser Ala Ala Ser Thr Asn Leu Asn Trp Gln Cys Pro 
            20                  25                  30          


Arg Ile Pro Tyr Ala Ala Ser Arg Asp Phe Ser Val Lys Tyr Val Val 
        35                  40                  45              


Pro Ser Phe Ser Ala Gly Gly Arg Val Gln Ala Thr Ala Ala Tyr Glu 
    50                  55                  60                  


Asp Ser Thr Asn Ser Ala Val Phe Val Ala Thr Arg Asn His Leu His 
65                  70                  75                  80  


Val Leu Gly Pro Asp Leu Gln Phe Ile Glu Asn Leu Thr Thr Gly Pro 
                85                  90                  95      


Ile Gly Asn Pro Gly Cys Gln Thr Cys Ala Ser Cys Gly Pro Gly Pro 
            100                 105                 110         


His Gly Pro Pro Lys Asp Thr Asp Thr Leu Val Leu Val Met Glu Pro 
        115                 120                 125             


Gly Leu Pro Ala Leu Val Ser Cys Gly Ser Thr Leu Gln Gly Arg Cys 
    130                 135                 140                 


Phe Leu His Glu Leu Glu Pro Arg Gly Lys Ala Leu His Leu Ala Ala 
145                 150                 155                 160 


Pro Ala Cys Leu Phe Ser Ala Asn Asn Asn Lys Pro Glu Ala Cys Thr 
                165                 170                 175     


Asp Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln 
            180                 185                 190         


Gly His Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Pro Glu Leu 
        195                 200                 205             


Ala Ala Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ser 
    210                 215                 220                 


Asp Thr Ser Gly Phe Gln Pro Gly Phe Pro Ser Leu Ser Val Leu Pro 
225                 230                 235                 240 


Lys Tyr Leu Ala Ser Tyr Leu Ile Lys Tyr Val Tyr Ser Phe His Ser 
                245                 250                 255     


Gly Asp Phe Val Tyr Phe Leu Thr Val Gln Pro Ile Ser Val Thr Ser 
            260                 265                 270         


Pro Pro Ser Ala Leu His Thr Arg Leu Val Arg Leu Asn Ala Val Glu 
        275                 280                 285             


Pro Glu Ile Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys His Phe Ala 
    290                 295                 300                 


Pro Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Thr Gln Pro Tyr Pro 
305                 310                 315                 320 


Val Leu Gln Ala Ala His Ser Ala Pro Val Asp Ala Lys Leu Ala Val 
                325                 330                 335     


Glu Leu Ser Ile Ser Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val 
            340                 345                 350         


Thr Val Lys Asp Gly Gly Ser Gly Met Gly Pro Asn Ser Val Val Cys 
        355                 360                 365             


Ala Phe Pro Ile Tyr His Leu Asn Ile Leu Ile Glu Glu Gly Val Glu 
    370                 375                 380                 


Tyr Cys Cys His Ser Ser Asn Ser Ser Ser Leu Leu Ser Arg Gly Leu 
385                 390                 395                 400 


Asp Phe Phe Gln Thr Pro Ser Phe Cys Pro Asn Pro Pro Gly Gly Glu 
                405                 410                 415     


Ala Ser Gly Pro Ser Ser Arg Cys His Tyr Phe Pro Leu Met Val His 
            420                 425                 430         


Ala Ser Phe Thr Arg Val Asp Leu Phe Asn Gly Leu Leu Gly Ser Val 
        435                 440                 445             


Lys Val Thr Ala Leu His Val Thr Arg Leu Gly Asn Val Thr Val Ala 
    450                 455                 460                 


His Met Gly Thr Val Asp Gly Arg Val Leu Gln Val Glu Ile Ala Arg 
465                 470                 475                 480 


Ser Leu Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu Gly Ser Ser 
                485                 490                 495     


Gly Gln Pro Val His Arg Asp Val Ser Arg Leu Gly Asn Asp Leu Leu 
            500                 505                 510         


Phe Ala Ser Gly Asp Gln Val Phe Lys Val Pro Ile Gln Gly Pro Gly 
        515                 520                 525             


Cys Arg His Phe Leu Thr Cys Trp Arg Cys Leu Arg Ala Gln Arg Phe 
    530                 535                 540                 


Met Gly Cys Gly Trp Cys Gly Asp Arg Cys Asp Arg Gln Lys Glu Cys 
545                 550                 555                 560 


Pro Gly Ser Trp Gln Gln Asp His Cys Pro Pro Glu Ile Ser Glu Phe 
                565                 570                 575     


Tyr Pro His Ser Gly Pro Leu Arg Gly Thr Thr Arg Leu Thr Leu Cys 
            580                 585                 590         


Gly Ser Asn Phe Tyr Leu Arg Pro Asp Asp Val Val Pro Glu Gly Thr 
        595                 600                 605             


His Gln Ile Thr Val Gly Gln Ser Pro Cys Arg Leu Leu Pro Lys Asp 
    610                 615                 620                 


Ser Ser Ser Pro Arg Pro Gly Ser Leu Lys Glu Phe Ile Gln Glu Leu 
625                 630                 635                 640 


Glu Cys Glu Leu Glu Pro Leu Val Thr Gln Ala Val Gly Thr Thr Asn 
                645                 650                 655     


Ile Ser Leu Val Ile Thr Asn Met Pro Ala Gly Lys His Phe Arg Val 
            660                 665                 670         


Glu Gly Ile Ser Val Gln Glu Gly Phe Ser Phe Gly Arg Ala Gln Val 
        675                 680                 685             


Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    690                 695                 700                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
705                 710                 715                 720 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                725                 730                 735     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            740                 745                 750         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        755                 760                 765             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    770                 775                 780                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
785                 790                 795                 800 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                805                 810                 815     


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
            820                 825                 830         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        835                 840                 845             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    850                 855                 860                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
865                 870                 875                 880 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                885                 890                 895     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            900                 905                 910         


Ser Pro Gly Lys 
        915     


<210>  51
<211>  2079
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(2079)

<400>  51
atg ggg ctg cct ctg ccg ctg ctt caa tcc tct ctt ctg cta atg ctt         48
Met Gly Leu Pro Leu Pro Leu Leu Gln Ser Ser Leu Leu Leu Met Leu           
1               5                   10                  15                

ctt ttg cgg ctg tcg gcg gcg tcc acc aac ctg aac tgg cag tgc cca         96
Leu Leu Arg Leu Ser Ala Ala Ser Thr Asn Leu Asn Trp Gln Cys Pro           
            20                  25                  30                    

cga ata ccc tac gca gcc tcc cga gac ttc agt gtc aag tac gtg gtc        144
Arg Ile Pro Tyr Ala Ala Ser Arg Asp Phe Ser Val Lys Tyr Val Val           
        35                  40                  45                        

ccc agc ttc tcc gcg ggg ggc cgg gta cag gcc acc gca gcc tac gag        192
Pro Ser Phe Ser Ala Gly Gly Arg Val Gln Ala Thr Ala Ala Tyr Glu           
    50                  55                  60                            

gac agt aca aat agt gcg gtg ttt gtg gcc aca cgc aat cac ctg cac        240
Asp Ser Thr Asn Ser Ala Val Phe Val Ala Thr Arg Asn His Leu His           
65                  70                  75                  80            

gtg ctt ggg cct gac ctg cag ttc ata gag aac ctg acc act ggc cct        288
Val Leu Gly Pro Asp Leu Gln Phe Ile Glu Asn Leu Thr Thr Gly Pro           
                85                  90                  95                

atc ggg aac cct ggc tgc cag act tgt gcg agc tgt ggt cca ggc cct        336
Ile Gly Asn Pro Gly Cys Gln Thr Cys Ala Ser Cys Gly Pro Gly Pro           
            100                 105                 110                   

cat gga cca cca aag gac aca gac aca ctg gtg cta gtg atg gag cca        384
His Gly Pro Pro Lys Asp Thr Asp Thr Leu Val Leu Val Met Glu Pro           
        115                 120                 125                       

ggt ttg cca gcc ctg gtc agc tgt ggc tca acc cta cag ggc cgc tgc        432
Gly Leu Pro Ala Leu Val Ser Cys Gly Ser Thr Leu Gln Gly Arg Cys           
    130                 135                 140                           

ttc ctg cat gag ctg gag cct cgg ggg aaa gcc ctg cac tta gca gct        480
Phe Leu His Glu Leu Glu Pro Arg Gly Lys Ala Leu His Leu Ala Ala           
145                 150                 155                 160           

cca gcc tgc cta ttc tca gca aac aat aac aag cct gag gcc tgc acg        528
Pro Ala Cys Leu Phe Ser Ala Asn Asn Asn Lys Pro Glu Ala Cys Thr           
                165                 170                 175               

gac tgt gtg gct agc ccc ctg ggc act cgt gtg act gtg gtg gag cag        576
Asp Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln           
            180                 185                 190                   

ggg cat gct tcc tac ttc tat gtg gca tct tcg cta gac cca gag ttg        624
Gly His Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Pro Glu Leu           
        195                 200                 205                       

gcc gct agc ttt agc ccc cgc tcg gtg tcc atc cgt cgt cta aag tct        672
Ala Ala Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ser           
    210                 215                 220                           

gat act tct gga ttc caa cca ggt ttt ccg tcg ctg tcg gtg ctg ccc        720
Asp Thr Ser Gly Phe Gln Pro Gly Phe Pro Ser Leu Ser Val Leu Pro           
225                 230                 235                 240           

aaa tat ttg gcc tcc tac ctc atc aaa tat gtg tac agc ttc cac tcg        768
Lys Tyr Leu Ala Ser Tyr Leu Ile Lys Tyr Val Tyr Ser Phe His Ser           
                245                 250                 255               

ggg gat ttt gtc tac ttt ctg act gtc cag ccc atc agt gtc aca agc        816
Gly Asp Phe Val Tyr Phe Leu Thr Val Gln Pro Ile Ser Val Thr Ser           
            260                 265                 270                   

cct ccc agt gcc ttg cat aca cgt ctg gtc cgg ctc aat gct gta gag        864
Pro Pro Ser Ala Leu His Thr Arg Leu Val Arg Leu Asn Ala Val Glu           
        275                 280                 285                       

cca gag att ggt gac tac cgg gag ctg gtc ttg gac tgt cat ttt gca        912
Pro Glu Ile Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys His Phe Ala           
    290                 295                 300                           

cct aaa cgc cgg cgc cgt gga gcc ccg gag ggc aca cag ccc tac cca        960
Pro Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Thr Gln Pro Tyr Pro           
305                 310                 315                 320           

gtg ctt cag gca gcc cac tct gct cca gtg gat gcc aaa ctg gct gtg       1008
Val Leu Gln Ala Ala His Ser Ala Pro Val Asp Ala Lys Leu Ala Val           
                325                 330                 335               

gaa ctg agc att tca gag ggc cag gaa gtg ctt ttt ggg gtc ttt gtg       1056
Glu Leu Ser Ile Ser Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val           
            340                 345                 350                   

acc gtc aag gat ggt ggc tct ggc atg ggt ccc aac tct gtt gta tgt       1104
Thr Val Lys Asp Gly Gly Ser Gly Met Gly Pro Asn Ser Val Val Cys           
        355                 360                 365                       

gcc ttc ccc att tac cac ctg aac atc ctg att gaa gag ggt gtc gaa       1152
Ala Phe Pro Ile Tyr His Leu Asn Ile Leu Ile Glu Glu Gly Val Glu           
    370                 375                 380                           

tat tgc tgt cac tct tca aat tct tct tcc ctg ttg tcg aga ggc ctt       1200
Tyr Cys Cys His Ser Ser Asn Ser Ser Ser Leu Leu Ser Arg Gly Leu           
385                 390                 395                 400           

gac ttc ttc cag acg ccc agt ttt tgt cct aat ccg cct ggt gga gag       1248
Asp Phe Phe Gln Thr Pro Ser Phe Cys Pro Asn Pro Pro Gly Gly Glu           
                405                 410                 415               

gcc tcc ggc ccc agc tcc cgt tgc cac tac ttc cct ttg atg gtc cac       1296
Ala Ser Gly Pro Ser Ser Arg Cys His Tyr Phe Pro Leu Met Val His           
            420                 425                 430                   

gct agc ttc acc cgt gtg gac ctc ttc aat gga ctg tta gga tca gtg       1344
Ala Ser Phe Thr Arg Val Asp Leu Phe Asn Gly Leu Leu Gly Ser Val           
        435                 440                 445                       

aag gtc acc gca ctg cat gtg aca cgt ctt ggc aat gtt aca gtg gcc       1392
Lys Val Thr Ala Leu His Val Thr Arg Leu Gly Asn Val Thr Val Ala           
    450                 455                 460                           

cac atg ggc act gtg gat ggg cgt gtc cta cag gtg gag ata gcc agg       1440
His Met Gly Thr Val Asp Gly Arg Val Leu Gln Val Glu Ile Ala Arg           
465                 470                 475                 480           

tca ctc aac tac ctg ctg tat gtg tcc aac ttc tcc ctg ggc agc agt       1488
Ser Leu Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu Gly Ser Ser           
                485                 490                 495               

gga cag cct gtt cat cgg gat gtc agc cgc ctc ggg aat gac cta ctc       1536
Gly Gln Pro Val His Arg Asp Val Ser Arg Leu Gly Asn Asp Leu Leu           
            500                 505                 510                   

ttt gcc tct ggg gac cag gtc ttc aag gtg ccc atc cag ggc cct ggc       1584
Phe Ala Ser Gly Asp Gln Val Phe Lys Val Pro Ile Gln Gly Pro Gly           
        515                 520                 525                       

tgt cgt cat ttt ctc acc tgt tgg cgt tgc ctg aga gca cag cgc ttc       1632
Cys Arg His Phe Leu Thr Cys Trp Arg Cys Leu Arg Ala Gln Arg Phe           
    530                 535                 540                           

atg gga tgt ggc tgg tgt ggg gac cgg tgt gac cgg cag aag gag tgt       1680
Met Gly Cys Gly Trp Cys Gly Asp Arg Cys Asp Arg Gln Lys Glu Cys           
545                 550                 555                 560           

cct ggc tcc tgg caa cag gac cac tgt ccg cct gag atc agt gag ttc       1728
Pro Gly Ser Trp Gln Gln Asp His Cys Pro Pro Glu Ile Ser Glu Phe           
                565                 570                 575               

tat cct cac agc ggg cct cta agg ggc act acg agg ctc acc ctt tgt       1776
Tyr Pro His Ser Gly Pro Leu Arg Gly Thr Thr Arg Leu Thr Leu Cys           
            580                 585                 590                   

ggc tcc aac ttc tac ctg cga cct gat gat gtc gta cct gag gga aca       1824
Gly Ser Asn Phe Tyr Leu Arg Pro Asp Asp Val Val Pro Glu Gly Thr           
        595                 600                 605                       

cac cag atc acc gtg ggc caa agt ccc tgc cga ctg ctg cct aag gac       1872
His Gln Ile Thr Val Gly Gln Ser Pro Cys Arg Leu Leu Pro Lys Asp           
    610                 615                 620                           

tct tca agc cct agg cca ggg tcc ctc aag gaa ttc ata cag gaa ctt       1920
Ser Ser Ser Pro Arg Pro Gly Ser Leu Lys Glu Phe Ile Gln Glu Leu           
625                 630                 635                 640           

gaa tgt gag ctg gag ccc ctg gtc acc cag gca gtg ggg act aca aac       1968
Glu Cys Glu Leu Glu Pro Leu Val Thr Gln Ala Val Gly Thr Thr Asn           
                645                 650                 655               

atc agc ctt gtc atc acc aac atg cca gca ggc aag cac ttc cga gtg       2016
Ile Ser Leu Val Ile Thr Asn Met Pro Ala Gly Lys His Phe Arg Val           
            660                 665                 670                   

gaa ggc atc tct gta cag gaa ggc ttc tct ttc gtg cat cat cat cat       2064
Glu Gly Ile Ser Val Gln Glu Gly Phe Ser Phe Val His His His His           
        675                 680                 685                       

cat cat cat cat tga                                                   2079
His His His His                                                           
    690                                                                   


<210>  52
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52

Met Gly Leu Pro Leu Pro Leu Leu Gln Ser Ser Leu Leu Leu Met Leu 
1               5                   10                  15      


Leu Leu Arg Leu Ser Ala Ala Ser Thr Asn Leu Asn Trp Gln Cys Pro 
            20                  25                  30          


Arg Ile Pro Tyr Ala Ala Ser Arg Asp Phe Ser Val Lys Tyr Val Val 
        35                  40                  45              


Pro Ser Phe Ser Ala Gly Gly Arg Val Gln Ala Thr Ala Ala Tyr Glu 
    50                  55                  60                  


Asp Ser Thr Asn Ser Ala Val Phe Val Ala Thr Arg Asn His Leu His 
65                  70                  75                  80  


Val Leu Gly Pro Asp Leu Gln Phe Ile Glu Asn Leu Thr Thr Gly Pro 
                85                  90                  95      


Ile Gly Asn Pro Gly Cys Gln Thr Cys Ala Ser Cys Gly Pro Gly Pro 
            100                 105                 110         


His Gly Pro Pro Lys Asp Thr Asp Thr Leu Val Leu Val Met Glu Pro 
        115                 120                 125             


Gly Leu Pro Ala Leu Val Ser Cys Gly Ser Thr Leu Gln Gly Arg Cys 
    130                 135                 140                 


Phe Leu His Glu Leu Glu Pro Arg Gly Lys Ala Leu His Leu Ala Ala 
145                 150                 155                 160 


Pro Ala Cys Leu Phe Ser Ala Asn Asn Asn Lys Pro Glu Ala Cys Thr 
                165                 170                 175     


Asp Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln 
            180                 185                 190         


Gly His Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Pro Glu Leu 
        195                 200                 205             


Ala Ala Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ser 
    210                 215                 220                 


Asp Thr Ser Gly Phe Gln Pro Gly Phe Pro Ser Leu Ser Val Leu Pro 
225                 230                 235                 240 


Lys Tyr Leu Ala Ser Tyr Leu Ile Lys Tyr Val Tyr Ser Phe His Ser 
                245                 250                 255     


Gly Asp Phe Val Tyr Phe Leu Thr Val Gln Pro Ile Ser Val Thr Ser 
            260                 265                 270         


Pro Pro Ser Ala Leu His Thr Arg Leu Val Arg Leu Asn Ala Val Glu 
        275                 280                 285             


Pro Glu Ile Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys His Phe Ala 
    290                 295                 300                 


Pro Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Thr Gln Pro Tyr Pro 
305                 310                 315                 320 


Val Leu Gln Ala Ala His Ser Ala Pro Val Asp Ala Lys Leu Ala Val 
                325                 330                 335     


Glu Leu Ser Ile Ser Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val 
            340                 345                 350         


Thr Val Lys Asp Gly Gly Ser Gly Met Gly Pro Asn Ser Val Val Cys 
        355                 360                 365             


Ala Phe Pro Ile Tyr His Leu Asn Ile Leu Ile Glu Glu Gly Val Glu 
    370                 375                 380                 


Tyr Cys Cys His Ser Ser Asn Ser Ser Ser Leu Leu Ser Arg Gly Leu 
385                 390                 395                 400 


Asp Phe Phe Gln Thr Pro Ser Phe Cys Pro Asn Pro Pro Gly Gly Glu 
                405                 410                 415     


Ala Ser Gly Pro Ser Ser Arg Cys His Tyr Phe Pro Leu Met Val His 
            420                 425                 430         


Ala Ser Phe Thr Arg Val Asp Leu Phe Asn Gly Leu Leu Gly Ser Val 
        435                 440                 445             


Lys Val Thr Ala Leu His Val Thr Arg Leu Gly Asn Val Thr Val Ala 
    450                 455                 460                 


His Met Gly Thr Val Asp Gly Arg Val Leu Gln Val Glu Ile Ala Arg 
465                 470                 475                 480 


Ser Leu Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu Gly Ser Ser 
                485                 490                 495     


Gly Gln Pro Val His Arg Asp Val Ser Arg Leu Gly Asn Asp Leu Leu 
            500                 505                 510         


Phe Ala Ser Gly Asp Gln Val Phe Lys Val Pro Ile Gln Gly Pro Gly 
        515                 520                 525             


Cys Arg His Phe Leu Thr Cys Trp Arg Cys Leu Arg Ala Gln Arg Phe 
    530                 535                 540                 


Met Gly Cys Gly Trp Cys Gly Asp Arg Cys Asp Arg Gln Lys Glu Cys 
545                 550                 555                 560 


Pro Gly Ser Trp Gln Gln Asp His Cys Pro Pro Glu Ile Ser Glu Phe 
                565                 570                 575     


Tyr Pro His Ser Gly Pro Leu Arg Gly Thr Thr Arg Leu Thr Leu Cys 
            580                 585                 590         


Gly Ser Asn Phe Tyr Leu Arg Pro Asp Asp Val Val Pro Glu Gly Thr 
        595                 600                 605             


His Gln Ile Thr Val Gly Gln Ser Pro Cys Arg Leu Leu Pro Lys Asp 
    610                 615                 620                 


Ser Ser Ser Pro Arg Pro Gly Ser Leu Lys Glu Phe Ile Gln Glu Leu 
625                 630                 635                 640 


Glu Cys Glu Leu Glu Pro Leu Val Thr Gln Ala Val Gly Thr Thr Asn 
                645                 650                 655     


Ile Ser Leu Val Ile Thr Asn Met Pro Ala Gly Lys His Phe Arg Val 
            660                 665                 670         


Glu Gly Ile Ser Val Gln Glu Gly Phe Ser Phe Val His His His His 
        675                 680                 685             


His His His His 
    690         


<210>  53
<211>  1248
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(1248)

<400>  53
atg tgg gtg acc aaa ctc ctg cca gcc ctg ctg ctg cag cat gtc ctc         48
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu           
1               5                   10                  15                

ctg cat ctc ctc ctg ctc ccc atc gcc atc ccc tat gca gag gga agg         96
Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Arg           
            20                  25                  30                    

agt gac cag gag ccg ctg tac cca gtg cag gtc agc tct gcg gac gct        144
Ser Asp Gln Glu Pro Leu Tyr Pro Val Gln Val Ser Ser Ala Asp Ala           
        35                  40                  45                        

cgg ctc atg gtc ttt gac aag acg gaa ggg acg tgg cgg ctg ctg tgc        192
Arg Leu Met Val Phe Asp Lys Thr Glu Gly Thr Trp Arg Leu Leu Cys           
    50                  55                  60                            

tcc tcg cgc tcc aac gcc agg gta gcc gga ctc agc tgc gag gag atg        240
Ser Ser Arg Ser Asn Ala Arg Val Ala Gly Leu Ser Cys Glu Glu Met           
65                  70                  75                  80            

ggc ttc ctc agg gca ctg acc cac tcc gag ctg gac gtg cga acg gcg        288
Gly Phe Leu Arg Ala Leu Thr His Ser Glu Leu Asp Val Arg Thr Ala           
                85                  90                  95                

ggc gcc aat ggc acg tcg ggc ttc ttc tgt gtg gac gag ggg agg ctg        336
Gly Ala Asn Gly Thr Ser Gly Phe Phe Cys Val Asp Glu Gly Arg Leu           
            100                 105                 110                   

ccc cac acc cag agg ctg ctg gag gtc atc tcc gtg tgt gat tgc ccc        384
Pro His Thr Gln Arg Leu Leu Glu Val Ile Ser Val Cys Asp Cys Pro           
        115                 120                 125                       

aga ggc cgt ttc ttg gcc gcc atc tgc caa gac tgt ggc cgc agg aag        432
Arg Gly Arg Phe Leu Ala Ala Ile Cys Gln Asp Cys Gly Arg Arg Lys           
    130                 135                 140                           

ctg ccc gtg gac gat gac gat aag atc gtg gga ggc cgg gac acc agc        480
Leu Pro Val Asp Asp Asp Asp Lys Ile Val Gly Gly Arg Asp Thr Ser           
145                 150                 155                 160           

ttg ggc cgg tgg ccg tgg caa gtc agc ctt cgc tat gat gga gca cac        528
Leu Gly Arg Trp Pro Trp Gln Val Ser Leu Arg Tyr Asp Gly Ala His           
                165                 170                 175               

ctc tgt ggg gga tcc ctg ctc tcc ggg gac tgg gtg ctg aca gcc gcc        576
Leu Cys Gly Gly Ser Leu Leu Ser Gly Asp Trp Val Leu Thr Ala Ala           
            180                 185                 190                   

cac tgc ttc ccg gag cgg aac cgg gtc ctg tcc cga tgg cga gtg ttt        624
His Cys Phe Pro Glu Arg Asn Arg Val Leu Ser Arg Trp Arg Val Phe           
        195                 200                 205                       

gcc ggt gcc gtg gcc cag gcc tct ccc cac ggt ctg cag ctg ggg gtg        672
Ala Gly Ala Val Ala Gln Ala Ser Pro His Gly Leu Gln Leu Gly Val           
    210                 215                 220                           

cag gct gtg gtc tac cac ggg ggc tat ctt ccc ttt cgg gac ccc aac        720
Gln Ala Val Val Tyr His Gly Gly Tyr Leu Pro Phe Arg Asp Pro Asn           
225                 230                 235                 240           

agc gag gag aac agc aac gat att gcc ctg gtc cac ctc tcc agt ccc        768
Ser Glu Glu Asn Ser Asn Asp Ile Ala Leu Val His Leu Ser Ser Pro           
                245                 250                 255               

ctg ccc ctc aca gaa tac atc cag cct gtg tgc ctc cca gct gcc ggc        816
Leu Pro Leu Thr Glu Tyr Ile Gln Pro Val Cys Leu Pro Ala Ala Gly           
            260                 265                 270                   

cag gcc ctg gtg gat ggc aag atc tgt acc gtg acg ggc tgg ggc aac        864
Gln Ala Leu Val Asp Gly Lys Ile Cys Thr Val Thr Gly Trp Gly Asn           
        275                 280                 285                       

acg cag tac tat ggc caa cag gcc ggg gta ctc cag gag gct cga gtc        912
Thr Gln Tyr Tyr Gly Gln Gln Ala Gly Val Leu Gln Glu Ala Arg Val           
    290                 295                 300                           

ccc ata atc agc aat gat gtc tgc aat ggc gct gac ttc tat gga aac        960
Pro Ile Ile Ser Asn Asp Val Cys Asn Gly Ala Asp Phe Tyr Gly Asn           
305                 310                 315                 320           

cag atc aag ccc aag atg ttc tgt gct ggc tac ccc gag ggt ggc att       1008
Gln Ile Lys Pro Lys Met Phe Cys Ala Gly Tyr Pro Glu Gly Gly Ile           
                325                 330                 335               

gat gcc tgc cag ggc gac agc ggt ggt ccc ttt gtg tgt gag gac agc       1056
Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Phe Val Cys Glu Asp Ser           
            340                 345                 350                   

atc tct cgg acg cca cgt tgg cgg ctg tgt ggc att gtg agt tgg ggc       1104
Ile Ser Arg Thr Pro Arg Trp Arg Leu Cys Gly Ile Val Ser Trp Gly           
        355                 360                 365                       

act ggc tgt gcc ctg gcc cag aag cca ggc gtc tac acc aaa gtc agt       1152
Thr Gly Cys Ala Leu Ala Gln Lys Pro Gly Val Tyr Thr Lys Val Ser           
    370                 375                 380                           

gac ttc cgg gag tgg atc ttc cag gcc ata aag act cac tcc gaa gcc       1200
Asp Phe Arg Glu Trp Ile Phe Gln Ala Ile Lys Thr His Ser Glu Ala           
385                 390                 395                 400           

agc ggc atg gtg acc cag ctc cac cat cac cat cac cat cac cat taa       1248
Ser Gly Met Val Thr Gln Leu His His His His His His His His               
                405                 410                 415               


<210>  54
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Arg 
            20                  25                  30          


Ser Asp Gln Glu Pro Leu Tyr Pro Val Gln Val Ser Ser Ala Asp Ala 
        35                  40                  45              


Arg Leu Met Val Phe Asp Lys Thr Glu Gly Thr Trp Arg Leu Leu Cys 
    50                  55                  60                  


Ser Ser Arg Ser Asn Ala Arg Val Ala Gly Leu Ser Cys Glu Glu Met 
65                  70                  75                  80  


Gly Phe Leu Arg Ala Leu Thr His Ser Glu Leu Asp Val Arg Thr Ala 
                85                  90                  95      


Gly Ala Asn Gly Thr Ser Gly Phe Phe Cys Val Asp Glu Gly Arg Leu 
            100                 105                 110         


Pro His Thr Gln Arg Leu Leu Glu Val Ile Ser Val Cys Asp Cys Pro 
        115                 120                 125             


Arg Gly Arg Phe Leu Ala Ala Ile Cys Gln Asp Cys Gly Arg Arg Lys 
    130                 135                 140                 


Leu Pro Val Asp Asp Asp Asp Lys Ile Val Gly Gly Arg Asp Thr Ser 
145                 150                 155                 160 


Leu Gly Arg Trp Pro Trp Gln Val Ser Leu Arg Tyr Asp Gly Ala His 
                165                 170                 175     


Leu Cys Gly Gly Ser Leu Leu Ser Gly Asp Trp Val Leu Thr Ala Ala 
            180                 185                 190         


His Cys Phe Pro Glu Arg Asn Arg Val Leu Ser Arg Trp Arg Val Phe 
        195                 200                 205             


Ala Gly Ala Val Ala Gln Ala Ser Pro His Gly Leu Gln Leu Gly Val 
    210                 215                 220                 


Gln Ala Val Val Tyr His Gly Gly Tyr Leu Pro Phe Arg Asp Pro Asn 
225                 230                 235                 240 


Ser Glu Glu Asn Ser Asn Asp Ile Ala Leu Val His Leu Ser Ser Pro 
                245                 250                 255     


Leu Pro Leu Thr Glu Tyr Ile Gln Pro Val Cys Leu Pro Ala Ala Gly 
            260                 265                 270         


Gln Ala Leu Val Asp Gly Lys Ile Cys Thr Val Thr Gly Trp Gly Asn 
        275                 280                 285             


Thr Gln Tyr Tyr Gly Gln Gln Ala Gly Val Leu Gln Glu Ala Arg Val 
    290                 295                 300                 


Pro Ile Ile Ser Asn Asp Val Cys Asn Gly Ala Asp Phe Tyr Gly Asn 
305                 310                 315                 320 


Gln Ile Lys Pro Lys Met Phe Cys Ala Gly Tyr Pro Glu Gly Gly Ile 
                325                 330                 335     


Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Phe Val Cys Glu Asp Ser 
            340                 345                 350         


Ile Ser Arg Thr Pro Arg Trp Arg Leu Cys Gly Ile Val Ser Trp Gly 
        355                 360                 365             


Thr Gly Cys Ala Leu Ala Gln Lys Pro Gly Val Tyr Thr Lys Val Ser 
    370                 375                 380                 


Asp Phe Arg Glu Trp Ile Phe Gln Ala Ile Lys Thr His Ser Glu Ala 
385                 390                 395                 400 


Ser Gly Met Val Thr Gln Leu His His His His His His His His 
                405                 410                 415 


<210>  55
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  55

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly 
            20                  25                  30      


<210>  56
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  56
ccactgctta ctggcttatc g                                                 21


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  57
tcttcagcat ctgccacatc                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  58
tagcgctacc ggactcagat                                                   20


<210>  59
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  59
agggcagtcc tgcaacat                                                     18


<210>  60
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  60
gagtccactg tgcccagaa                                                    19


<210>  61
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  61
acagggtcca cagcaggcac tc                                                22


<210>  62
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  62
caatgccaac tcccgtcag                                                    19


<210>  63
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  63
gtcacaggct tgcggatga                                                    19


<210>  64
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  64
agatccggaa gctcatcaaa gatgggct                                          28


<210>  65
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(30)

<400>  65
gga ttc atc ttc agt gaa tat ggc atg aac                                 30
Gly Phe Ile Phe Ser Glu Tyr Gly Met Asn                                   
1               5                   10                                    


<210>  66
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  66

Gly Phe Ile Phe Ser Glu Tyr Gly Met Asn 
1               5                   10  


<210>  67
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(60)

<400>  67
gct cgc ata cga cct aaa cct aat aat tat gca acc tat tac gcg gat         48
Ala Arg Ile Arg Pro Lys Pro Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp           
1               5                   10                  15                

tcg gtg aag ggc                                                         60
Ser Val Lys Gly                                                           
            20                                                            


<210>  68
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  68

Ala Arg Ile Arg Pro Lys Pro Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
1               5                   10                  15      


Ser Val Lys Gly 
            20  


<210>  69
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(39)

<400>  69
aca aga gac tat agc gga tac cac aat gct ttt gat tcc                     39
Thr Arg Asp Tyr Ser Gly Tyr His Asn Ala Phe Asp Ser                       
1               5                   10                                    


<210>  70
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  70

Thr Arg Asp Tyr Ser Gly Tyr His Asn Ala Phe Asp Ser 
1               5                   10              


<210>  71
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(33)

<400>  71
aag gct agt cag aac att aac cag tac tta cac                             33
Lys Ala Ser Gln Asn Ile Asn Gln Tyr Leu His                               
1               5                   10                                    


<210>  72
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  72

Lys Ala Ser Gln Asn Ile Asn Gln Tyr Leu His 
1               5                   10      


<210>  73
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(21)

<400>  73
agt gcg tcc aat ctg cag gca                                             21
Ser Ala Ser Asn Leu Gln Ala                                               
1               5                                                         


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  74

Ser Ala Ser Asn Leu Gln Ala 
1               5           


<210>  75
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(24)

<400>  75
caa caa ggt tat aca cct cgc acg                                         24
Gln Gln Gly Tyr Thr Pro Arg Thr                                           
1               5                                                         


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  76

Gln Gln Gly Tyr Thr Pro Arg Thr 
1               5               


<210>  77
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(30)

<400>  77
ggc ttc acc ttc agc agc tac gct atg agc                                 30
Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser                                   
1               5                   10                                    


<210>  78
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  78

Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   10  


<210>  79
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(51)

<400>  79
gcc att agc agc agc ggc agc agc act tac tat gcc gat agc gtc aag         48
Ala Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val Lys           
1               5                   10                  15                

ggc                                                                     51
Gly                                                                       
                                                                          


<210>  80
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  80

Ala Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  81
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(45)

<400>  81
gac atg tac act tac ggt cgt tac ccg gaa ccg cgt ttc gac tac             45
Asp Met Tyr Thr Tyr Gly Arg Tyr Pro Glu Pro Arg Phe Asp Tyr               
1               5                   10                  15                


<210>  82
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  82

Asp Met Tyr Thr Tyr Gly Arg Tyr Pro Glu Pro Arg Phe Asp Tyr 
1               5                   10                  15  


<210>  83
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(51)

<400>  83
aaa agc agc cag agc gtg ctg tac agc agc aac aac aaa aac tac ctg         48
Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu           
1               5                   10                  15                

gcg                                                                     51
Ala                                                                       
                                                                          


<210>  84
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  84

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  85
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Arificial Sequence


<220>
<221>  CDS
<222>  (1)..(21)

<400>  85
tgg gcg agc acc cgt gaa agc                                             21
Trp Ala Ser Thr Arg Glu Ser                                               
1               5                                                         


<210>  86
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  86

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  87
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  CDS
<222>  (1)..(27)

<400>  87
cag caa tac tac tcc acc cct ttt acg                                     27
Gln Gln Tyr Tyr Ser Thr Pro Phe Thr                                       
1               5                                                         


<210>  88
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  88

Gln Gln Tyr Tyr Ser Thr Pro Phe Thr 
1               5                   


