
                                SEQUENCE LISTING

<110> INVISTA North America S.a r.l.

<120> METHODS FOR BIOSYNTHESIS OF ISOBUTENE
  

<130> 35643-0022WO1

<150> US 61/730,549       
<151> 2012-11-28  

<160> 12

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 156
<212> PRT
<213> Pseudomonas aeruginosa

<400> 1
Met Ser Gln Val Gln Asn Ile Pro Tyr Ala Glu Leu Glu Val Gly Gln
 1               5                  10                  15      
Lys Ala Glu Tyr Thr Ser Ser Ile Ala Glu Arg Asp Leu Gln Leu Phe
            20                  25                  30          
Ala Ala Val Ser Gly Asp Arg Asn Pro Val His Leu Asp Ala Ala Tyr
        35                  40                  45              
Ala Ala Thr Thr Gln Phe Lys Glu Arg Ile Ala His Gly Met Leu Ser
    50                  55                  60                  
Gly Ala Leu Ile Ser Ala Ala Ile Ala Thr Val Leu Pro Gly Pro Gly
65                  70                  75                  80  
Thr Ile Tyr Leu Gly Gln Thr Leu Arg Phe Thr Arg Pro Val Lys Leu
                85                  90                  95      
Gly Asp Asp Leu Lys Val Glu Leu Glu Val Leu Glu Lys Leu Pro Lys
            100                 105                 110         
Asn Arg Val Arg Met Ala Thr Arg Val Phe Asn Gln Ala Gly Lys Gln
        115                 120                 125             
Val Val Asp Gly Glu Ala Glu Ile Met Ala Pro Glu Glu Lys Leu Ser
    130                 135                 140                 
Val Glu Leu Ala Glu Leu Pro Pro Ile Ser Ile Gly
145                 150                 155     


<210> 2
<211> 134
<212> PRT
<213> Aeromonas punctata

<400> 2
Met Ser Ala Gln Ser Leu Glu Val Gly Gln Lys Ala Arg Leu Ser Lys
 1               5                  10                  15      
Arg Phe Gly Ala Ala Glu Val Ala Ala Phe Ala Ala Leu Ser Glu Asp
            20                  25                  30          
Phe Asn Pro Leu His Leu Asp Pro Ala Phe Ala Ala Thr Thr Ala Phe
        35                  40                  45              
Glu Arg Pro Ile Val His Gly Met Leu Leu Ala Ser Leu Phe Ser Gly
    50                  55                  60                  
Leu Leu Gly Gln Gln Leu Pro Gly Lys Gly Ser Ile Tyr Leu Gly Gln
65                  70                  75                  80  
Ser Leu Ser Phe Lys Leu Pro Val Phe Val Gly Asp Glu Val Thr Ala
                85                  90                  95      
Glu Val Glu Val Thr Ala Leu Arg Glu Asp Lys Pro Ile Ala Thr Leu
            100                 105                 110         
Thr Thr Arg Ile Phe Thr Gln Gly Gly Ala Leu Ala Val Thr Gly Glu
        115                 120                 125             
Ala Val Val Lys Leu Pro
    130                 


<210> 3
<211> 156
<212> PRT
<213> Pseudomonas putida

<400> 3
Met Ser Gln Val Thr Asn Thr Pro Tyr Glu Ala Leu Glu Val Gly Gln
 1               5                  10                  15      
Lys Ala Glu Tyr Lys Lys Ser Val Glu Glu Arg Asp Ile Gln Leu Phe
            20                  25                  30          
Ala Ala Met Ser Gly Asp His Asn Pro Val His Leu Asp Ala Glu Phe
        35                  40                  45              
Ala Ala Lys Ser Met Phe Arg Glu Arg Ile Ala His Gly Met Phe Ser
    50                  55                  60                  
Gly Ala Leu Ile Ser Ala Ala Val Ala Cys Thr Leu Pro Gly Pro Gly
65                  70                  75                  80  
Thr Ile Tyr Leu Gly Gln Gln Met Ser Phe Gln Lys Pro Val Lys Ile
                85                  90                  95      
Gly Asp Thr Leu Thr Val Arg Leu Glu Ile Leu Glu Lys Leu Pro Lys
            100                 105                 110         
Phe Lys Val Arg Ile Ala Thr Asn Val Tyr Asn Gln Asn Asp Glu Leu
        115                 120                 125             
Val Val Ala Gly Glu Ala Glu Ile Leu Ala Pro Arg Lys Gln Gln Thr
    130                 135                 140                 
Val Glu Leu Val Ser Pro Pro Asn Phe Val Ala Ser
145                 150                 155     


<210> 4
<211> 258
<212> PRT
<213> Bacillus subtilis

<400> 4
Met Asn Ala Ile Ser Leu Ala Val Asp Gln Phe Val Ala Val Leu Thr
 1               5                  10                  15      
Ile His Asn Pro Pro Ala Asn Ala Leu Ser Ser Arg Ile Leu Glu Glu
            20                  25                  30          
Leu Ser Ser Cys Leu Asp Gln Cys Glu Thr Asp Ala Gly Val Arg Ser
        35                  40                  45              
Ile Ile Ile His Gly Glu Gly Arg Phe Phe Ser Ala Gly Ala Asp Ile
    50                  55                  60                  
Lys Glu Phe Thr Ser Leu Lys Gly Asn Glu Asp Ser Ser Leu Leu Ala
65                  70                  75                  80  
Glu Arg Gly Gln Gln Leu Met Glu Arg Ile Glu Ser Phe Pro Lys Pro
                85                  90                  95      
Ile Ile Ala Ala Ile His Gly Ala Ala Leu Gly Gly Gly Leu Glu Leu
            100                 105                 110         
Ala Met Ala Cys His Ile Arg Ile Ala Ala Glu Asp Ala Lys Leu Gly
        115                 120                 125             
Leu Pro Glu Leu Asn Leu Gly Ile Ile Pro Gly Phe Ala Gly Thr Gln
    130                 135                 140                 
Arg Leu Pro Arg Tyr Val Gly Thr Ala Lys Ala Leu Glu Leu Ile Gly
145                 150                 155                 160 
Ser Gly Glu Pro Ile Ser Gly Lys Glu Ala Leu Asp Leu Gly Leu Val
                165                 170                 175     
Ser Ile Gly Ala Lys Asp Glu Ala Glu Val Ile Glu Lys Ala Lys Ala
            180                 185                 190         
Leu Ala Ala Lys Phe Ala Glu Lys Ser Pro Gln Thr Leu Ala Ser Leu
        195                 200                 205             
Leu Glu Leu Leu Tyr Ser Asn Lys Val Tyr Ser Tyr Glu Gly Ser Leu
    210                 215                 220                 
Lys Leu Glu Ala Lys Arg Phe Gly Glu Ala Phe Glu Ser Glu Asp Ala
225                 230                 235                 240 
Lys Glu Gly Ile Gln Ala Phe Leu Glu Lys Arg Lys Pro Gln Phe Lys
                245                 250                 255     
Gly Glu
        


<210> 5
<211> 408
<212> PRT
<213> Clostridium difficile

<400> 5
Met Ser Glu Lys Lys Glu Ala Arg Val Val Ile Asn Asp Leu Leu Ala
 1               5                  10                  15      
Glu Gln Tyr Ala Asn Ala Phe Lys Ala Lys Glu Glu Gly Arg Pro Val
            20                  25                  30          
Gly Trp Ser Thr Ser Val Phe Pro Gln Glu Leu Ala Glu Val Phe Asp
        35                  40                  45              
Leu Asn Val Leu Tyr Pro Glu Asn Gln Ala Ala Gly Val Ala Ala Lys
    50                  55                  60                  
Lys Gly Ser Leu Glu Leu Cys Glu Ile Ala Glu Ser Lys Gly Tyr Ser
65                  70                  75                  80  
Ile Asp Leu Cys Ala Tyr Ala Arg Thr Asn Phe Gly Leu Leu Glu Asn
                85                  90                  95      
Gly Gly Cys Glu Ala Leu Asp Met Pro Ala Pro Asp Phe Leu Leu Cys
            100                 105                 110         
Cys Asn Asn Ile Cys Asn Gln Val Ile Lys Trp Tyr Glu Asn Ile Ser
        115                 120                 125             
Arg Glu Leu Asp Ile Pro Leu Ile Met Ile Asp Thr Thr Phe Asn Asn
    130                 135                 140                 
Glu Asp Glu Val Thr Gln Ser Arg Ile Asp Tyr Ile Lys Ala Gln Phe
145                 150                 155                 160 
Glu Glu Ala Ile Lys Gln Leu Glu Ile Ile Ser Gly Lys Lys Phe Asp
                165                 170                 175     
Pro Lys Lys Phe Glu Glu Val Met Lys Ile Ser Ala Glu Asn Gly Arg
            180                 185                 190         
Leu Trp Lys Tyr Ser Met Ser Leu Pro Ala Asp Ser Ser Pro Ser Pro
        195                 200                 205             
Met Asn Gly Phe Asp Leu Phe Thr Tyr Met Ala Val Ile Val Cys Ala
    210                 215                 220                 
Arg Gly Lys Lys Glu Thr Thr Glu Ala Phe Lys Leu Leu Ile Glu Glu
225                 230                 235                 240 
Leu Glu Asp Asn Met Lys Thr Gly Lys Ser Ser Phe Arg Gly Glu Glu
                245                 250                 255     
Lys Tyr Arg Ile Met Met Glu Gly Ile Pro Cys Trp Pro Tyr Ile Gly
            260                 265                 270         
Tyr Lys Met Lys Thr Leu Ala Lys Phe Gly Val Asn Met Thr Gly Ser
        275                 280                 285             
Val Tyr Pro His Ala Trp Ala Leu Gln Tyr Glu Val Asn Asp Leu Asp
    290                 295                 300                 
Gly Met Ala Val Ala Tyr Ser Thr Met Phe Asn Asn Val Asn Leu Asp
305                 310                 315                 320 
Arg Met Thr Lys Tyr Arg Val Asp Ser Leu Val Glu Gly Lys Cys Asp
                325                 330                 335     
Gly Ala Phe Tyr His Met Asn Arg Ser Cys Lys Leu Met Ser Leu Ile
            340                 345                 350         
Gln Tyr Glu Met Gln Arg Arg Ala Ala Glu Glu Thr Gly Leu Pro Tyr
        355                 360                 365             
Ala Gly Phe Asp Gly Asp Gln Ala Asp Pro Arg Ala Phe Thr Asn Ala
    370                 375                 380                 
Gln Phe Glu Thr Arg Ile Gln Gly Leu Val Glu Val Met Glu Glu Arg
385                 390                 395                 400 
Lys Lys Leu Asn Arg Gly Glu Ile
                405             


<210> 6
<211> 375
<212> PRT
<213> Clostridium difficile

<400> 6
Met Glu Ala Ile Leu Ser Lys Met Lys Glu Val Val Glu Asn Pro Asn
 1               5                  10                  15      
Ala Ala Val Lys Lys Tyr Lys Ser Glu Thr Gly Lys Lys Ala Ile Gly
            20                  25                  30          
Cys Phe Pro Val Tyr Cys Pro Glu Glu Ile Ile His Ala Ala Gly Met
        35                  40                  45              
Leu Pro Val Gly Ile Trp Gly Gly Gln Thr Glu Leu Asp Leu Ala Lys
    50                  55                  60                  
Gln Tyr Phe Pro Ala Phe Ala Cys Ser Ile Met Gln Ser Cys Leu Glu
65                  70                  75                  80  
Tyr Gly Leu Lys Gly Ala Tyr Asp Glu Leu Ser Gly Val Ile Ile Pro
                85                  90                  95      
Gly Met Cys Asp Thr Leu Ile Cys Leu Gly Gln Asn Trp Lys Ser Ala
            100                 105                 110         
Val Pro His Ile Lys Tyr Ile Ser Leu Val His Pro Gln Asn Arg Lys
        115                 120                 125             
Leu Glu Ala Gly Val Lys Tyr Leu Ile Ser Glu Tyr Lys Gly Val Lys
    130                 135                 140                 
Arg Glu Leu Glu Glu Ile Cys Gly Tyr Glu Ile Glu Glu Ala Lys Ile
145                 150                 155                 160 
His Glu Ser Ile Glu Val Tyr Asn Glu His Arg Lys Thr Met Arg Asp
                165                 170                 175     
Phe Val Glu Val Ala Tyr Lys His Ser Asn Thr Ile Lys Pro Ser Ile
            180                 185                 190         
Arg Ser Leu Val Ile Lys Ser Gly Phe Phe Met Arg Lys Glu Glu His
        195                 200                 205             
Thr Glu Leu Val Lys Asp Leu Ile Ala Lys Leu Asn Ala Met Pro Glu
    210                 215                 220                 
Glu Val Cys Ser Gly Lys Lys Val Leu Leu Thr Gly Ile Leu Ala Asp
225                 230                 235                 240 
Ser Lys Asp Ile Leu Asp Ile Leu Glu Asp Asn Asn Ile Ser Val Val
                245                 250                 255     
Ala Asp Asp Leu Ala Gln Glu Thr Arg Gln Phe Arg Thr Asp Val Pro
            260                 265                 270         
Ala Gly Asp Asp Ala Leu Glu Arg Leu Ala Arg Gln Trp Ser Asn Ile
        275                 280                 285             
Glu Gly Cys Ser Leu Ala Tyr Asp Pro Lys Lys Lys Arg Gly Ser Leu
    290                 295                 300                 
Ile Val Asp Glu Val Lys Lys Lys Asp Ile Asp Gly Val Ile Phe Cys
305                 310                 315                 320 
Met Met Lys Phe Cys Asp Pro Glu Glu Tyr Asp Tyr Pro Leu Val Arg
                325                 330                 335     
Lys Asp Ile Glu Asp Ser Gly Ile Pro Thr Leu Tyr Val Glu Ile Asp
            340                 345                 350         
Gln Gln Thr Gln Asn Asn Glu Gln Ala Arg Thr Arg Ile Gln Thr Phe
        355                 360                 365             
Ala Glu Met Met Ser Leu Ala
    370                 375 


<210> 7
<211> 266
<212> PRT
<213> Clostridium difficile

<400> 7
Met Tyr Thr Met Gly Leu Asp Ile Gly Ser Thr Ala Ser Lys Gly Val
 1               5                  10                  15      
Ile Leu Lys Asn Gly Glu Asp Ile Val Ala Ser Glu Thr Ile Ser Ser
            20                  25                  30          
Gly Thr Gly Thr Thr Gly Pro Ser Arg Val Leu Glu Lys Leu Tyr Gly
        35                  40                  45              
Lys Thr Gly Leu Ala Arg Glu Asp Ile Lys Lys Val Val Val Thr Gly
    50                  55                  60                  
Tyr Gly Arg Met Asn Tyr Ser Asp Ala Asp Lys Gln Ile Ser Glu Leu
65                  70                  75                  80  
Ser Cys His Ala Arg Gly Val Asn Phe Ile Ile Pro Glu Thr Arg Thr
                85                  90                  95      
Ile Ile Asp Ile Gly Gly Gln Asp Ala Lys Val Leu Lys Leu Asp Asn
            100                 105                 110         
Asn Gly Arg Leu Leu Asn Phe Leu Met Asn Asp Lys Cys Ala Ala Gly
        115                 120                 125             
Thr Gly Arg Phe Leu Asp Val Met Ala Lys Ile Ile Glu Val Asp Val
    130                 135                 140                 
Ser Glu Leu Gly Ser Ile Ser Met Asn Ser Gln Asn Glu Val Ser Ile
145                 150                 155                 160 
Ser Ser Thr Cys Thr Val Phe Ala Glu Ser Glu Val Ile Ser His Leu
                165                 170                 175     
Ser Glu Asn Ala Lys Ile Glu Asp Ile Val Ala Gly Ile His Thr Ser
            180                 185                 190         
Val Ala Lys Arg Val Ser Ser Leu Val Lys Arg Ile Gly Val Gln Arg
        195                 200                 205             
Asn Val Val Met Val Gly Gly Val Ala Arg Asn Ser Gly Ile Val Arg
    210                 215                 220                 
Ala Met Ala Arg Glu Ile Asn Thr Glu Ile Ile Val Pro Asp Ile Pro
225                 230                 235                 240 
Gln Leu Thr Gly Ala Leu Gly Ala Ala Leu Tyr Ala Phe Asp Glu Ala
                245                 250                 255     
Lys Glu Ser Gln Lys Glu Val Lys Asn Ile
            260                 265     


<210> 8
<211> 477
<212> PRT
<213> Acidaminococcus fermentans

<400> 8
Met Pro Lys Thr Val Ser Pro Gly Val Gln Ala Leu Arg Asp Val Val
 1               5                  10                  15      
Glu Lys Val Tyr Arg Glu Leu Arg Glu Ala Lys Glu Arg Gly Glu Lys
            20                  25                  30          
Val Gly Trp Ser Ser Ser Lys Phe Pro Cys Glu Leu Ala Glu Ser Phe
        35                  40                  45              
Gly Leu His Val Gly Tyr Pro Glu Asn Gln Ala Ala Gly Ile Ala Ala
    50                  55                  60                  
Asn Arg Asp Gly Glu Val Met Cys Gln Ala Ala Glu Asp Ile Gly Tyr
65                  70                  75                  80  
Asp Asn Asp Ile Cys Gly Tyr Ala Arg Ile Ser Leu Ala Tyr Ala Ala
                85                  90                  95      
Gly Phe Arg Gly Ala Asn Lys Met Asp Lys Asp Gly Asn Tyr Val Ile
            100                 105                 110         
Asn Pro His Ser Gly Lys Gln Met Lys Asp Ala Asn Gly Lys Lys Val
        115                 120                 125             
Phe Asp Ala Asp Gly Lys Pro Val Ile Asp Pro Lys Thr Leu Lys Pro
    130                 135                 140                 
Phe Ala Thr Thr Asp Asn Ile Tyr Glu Ile Ala Ala Leu Pro Glu Gly
145                 150                 155                 160 
Glu Glu Lys Thr Arg Arg Gln Asn Ala Leu His Lys Tyr Arg Gln Met
                165                 170                 175     
Thr Met Pro Met Pro Asp Phe Val Leu Cys Cys Asn Asn Ile Cys Asn
            180                 185                 190         
Cys Met Thr Lys Trp Tyr Glu Asp Ile Ala Arg Arg His Asn Ile Pro
        195                 200                 205             
Leu Ile Met Ile Asp Val Pro Tyr Asn Glu Phe Asp His Val Asn Glu
    210                 215                 220                 
Ala Asn Val Lys Tyr Ile Arg Ser Gln Leu Asp Thr Ala Ile Arg Gln
225                 230                 235                 240 
Met Glu Glu Ile Thr Gly Lys Lys Phe Asp Glu Asp Lys Phe Glu Gln
                245                 250                 255     
Cys Cys Gln Asn Ala Asn Arg Thr Ala Lys Ala Trp Leu Lys Val Cys
            260                 265                 270         
Asp Tyr Leu Gln Tyr Lys Pro Ala Pro Phe Asn Gly Phe Asp Leu Phe
        275                 280                 285             
Asn His Met Ala Asp Val Val Thr Ala Arg Gly Arg Val Glu Ala Ala
    290                 295                 300                 
Glu Ala Phe Glu Leu Leu Ala Lys Glu Leu Glu Gln His Val Lys Glu
305                 310                 315                 320 
Gly Thr Thr Thr Ala Pro Phe Lys Glu Gln His Arg Ile Met Phe Glu
                325                 330                 335     
Gly Ile Pro Cys Trp Pro Lys Leu Pro Asn Leu Phe Lys Pro Leu Lys
            340                 345                 350         
Ala Asn Gly Leu Asn Ile Thr Gly Val Val Tyr Ala Pro Ala Phe Gly
        355                 360                 365             
Phe Val Tyr Asn Asn Leu Asp Glu Leu Val Lys Ala Tyr Cys Lys Ala
    370                 375                 380                 
Pro Asn Ser Val Ser Ile Glu Gln Gly Val Ala Trp Arg Glu Gly Leu
385                 390                 395                 400 
Ile Arg Asp Asn Lys Val Asp Gly Val Leu Val His Tyr Asn Arg Ser
                405                 410                 415     
Cys Lys Pro Trp Ser Gly Tyr Met Pro Glu Met Gln Arg Arg Phe Thr
            420                 425                 430         
Lys Asp Met Gly Ile Pro Thr Ala Gly Phe Asp Gly Asp Gln Ala Asp
        435                 440                 445             
Pro Arg Asn Phe Asn Ala Ala Gln Tyr Glu Thr Arg Val Gln Gly Leu
    450                 455                 460                 
Val Glu Ala Met Glu Ala Asn Asp Glu Lys Lys Gly Lys
465                 470                 475         


<210> 9
<211> 379
<212> PRT
<213> Acidaminococcus fermentans

<400> 9
Met Ala Ile Ser Ala Leu Ile Glu Glu Phe Gln Lys Val Ser Ala Ser
 1               5                  10                  15      
Pro Lys Thr Met Leu Ala Lys Tyr Lys Ala Gln Gly Lys Lys Ala Ile
            20                  25                  30          
Gly Cys Leu Pro Tyr Tyr Val Pro Glu Glu Leu Val Tyr Ala Ala Gly
        35                  40                  45              
Met Val Pro Met Gly Val Trp Gly Cys Asn Gly Lys Gln Glu Val Arg
    50                  55                  60                  
Ser Lys Glu Tyr Cys Ala Ser Phe Tyr Cys Thr Ile Ala Gln Gln Ser
65                  70                  75                  80  
Leu Glu Met Leu Leu Asp Gly Thr Leu Asp Gly Leu Asp Gly Ile Ile
                85                  90                  95      
Thr Pro Val Leu Cys Asp Thr Leu Arg Pro Met Ser Gln Asn Phe Lys
            100                 105                 110         
Val Ala Met Lys Asp Lys Met Pro Val Ile Phe Leu Ala His Pro Gln
        115                 120                 125             
Val Arg Gln Asn Ala Ala Gly Lys Gln Phe Thr Tyr Asp Ala Tyr Ser
    130                 135                 140                 
Glu Val Lys Gly His Leu Glu Glu Ile Cys Gly His Glu Ile Thr Asn
145                 150                 155                 160 
Asp Ala Ile Leu Asp Ala Ile Lys Val Tyr Asn Lys Ser Arg Ala Ala
                165                 170                 175     
Arg Arg Glu Phe Cys Lys Leu Ala Asn Glu His Pro Asp Leu Ile Pro
            180                 185                 190         
Ala Ser Val Arg Ala Thr Val Leu Arg Ala Ala Tyr Phe Met Leu Lys
        195                 200                 205             
Asp Glu Tyr Thr Glu Lys Leu Glu Glu Leu Asn Lys Glu Leu Ala Ala
    210                 215                 220                 
Ala Pro Ala Gly Lys Phe Asp Gly His Lys Val Val Val Ser Gly Ile
225                 230                 235                 240 
Ile Tyr Asn Met Pro Gly Ile Leu Lys Ala Met Asp Asp Asn Lys Leu
                245                 250                 255     
Ala Ile Ala Ala Asp Asp Cys Ala Tyr Glu Ser Arg Ser Phe Ala Val
            260                 265                 270         
Asp Ala Pro Glu Asp Leu Asp Asn Gly Leu Gln Ala Leu Ala Val Gln
        275                 280                 285             
Phe Ser Lys Gln Lys Asn Asp Val Leu Leu Tyr Asp Pro Glu Phe Ala
    290                 295                 300                 
Lys Asn Thr Arg Ser Glu His Val Cys Asn Leu Val Lys Glu Ser Gly
305                 310                 315                 320 
Ala Glu Gly Leu Ile Val Phe Met Met Gln Phe Cys Asp Pro Glu Glu
                325                 330                 335     
Met Glu Tyr Pro Asp Leu Lys Lys Ala Leu Asp Ala His His Ile Pro
            340                 345                 350         
His Val Lys Ile Gly Val Asp Gln Met Thr Arg Asp Phe Gly Gln Ala
        355                 360                 365             
Gln Thr Ala Leu Glu Ala Phe Ala Glu Ser Leu
    370                 375                 


<210> 10
<211> 260
<212> PRT
<213> Acidaminococcus fermentans

<400> 10
Met Ser Ile Tyr Thr Leu Gly Ile Asp Val Gly Ser Thr Ala Ser Lys
 1               5                  10                  15      
Cys Ile Ile Leu Lys Asp Gly Lys Glu Ile Val Ala Lys Ser Leu Val
            20                  25                  30          
Ala Val Gly Thr Gly Thr Ser Gly Pro Ala Arg Ser Ile Ser Glu Val
        35                  40                  45              
Leu Glu Asn Ala His Met Lys Lys Glu Asp Met Ala Phe Thr Leu Ala
    50                  55                  60                  
Thr Gly Tyr Gly Arg Asn Ser Leu Glu Gly Ile Ala Asp Lys Gln Met
65                  70                  75                  80  
Ser Glu Leu Ser Cys His Ala Met Gly Ala Ser Phe Ile Trp Pro Asn
                85                  90                  95      
Val His Thr Val Ile Asp Ile Gly Gly Gln Asp Val Lys Val Ile His
            100                 105                 110         
Val Glu Asn Gly Thr Met Thr Asn Phe Gln Met Asn Asp Lys Cys Ala
        115                 120                 125             
Ala Gly Thr Gly Arg Phe Leu Asp Val Met Ala Asn Ile Leu Glu Val
    130                 135                 140                 
Lys Val Ser Asp Leu Ala Glu Leu Gly Ala Lys Ser Thr Lys Arg Val
145                 150                 155                 160 
Ala Ile Ser Ser Thr Cys Thr Val Phe Ala Glu Ser Glu Val Ile Ser
                165                 170                 175     
Gln Leu Ser Lys Gly Thr Asp Lys Ile Asp Ile Ile Ala Gly Ile His
            180                 185                 190         
Arg Ser Val Ala Ser Arg Val Ile Gly Leu Ala Asn Arg Val Gly Ile
        195                 200                 205             
Val Lys Asp Val Val Met Thr Gly Gly Val Ala Gln Asn Tyr Gly Val
    210                 215                 220                 
Arg Gly Ala Leu Glu Glu Gly Leu Gly Val Glu Ile Lys Thr Ser Pro
225                 230                 235                 240 
Leu Ala Gln Tyr Asn Gly Ala Leu Gly Ala Ala Leu Tyr Ala Tyr Lys
                245                 250                 255     
Lys Ala Ala Lys
            260 


<210> 11
<211> 387
<212> PRT
<213> Pseudomonas aeruginosa

<400> 11
Met Thr Tyr Pro Ser Leu Asn Phe Ala Leu Gly Glu Thr Ile Asp Met
 1               5                  10                  15      
Leu Arg Asp Gln Val Arg Gly Phe Val Ala Ala Glu Leu Gln Pro Arg
            20                  25                  30          
Ala Ala Gln Ile Asp Gln Asp Asn Gln Phe Pro Met Asp Met Trp Arg
        35                  40                  45              
Lys Phe Gly Glu Met Gly Leu Leu Gly Ile Thr Val Asp Glu Glu Tyr
    50                  55                  60                  
Gly Gly Ser Ala Leu Gly Tyr Leu Ala His Ala Val Val Met Glu Glu
65                  70                  75                  80  
Ile Ser Arg Ala Ser Ala Ser Val Ala Leu Ser Tyr Gly Ala His Ser
                85                  90                  95      
Asn Leu Cys Val Asn Gln Ile Lys Arg Asn Gly Asn Ala Glu Gln Lys
            100                 105                 110         
Ala Arg Tyr Leu Pro Ala Leu Val Ser Gly Glu His Ile Gly Ala Leu
        115                 120                 125             
Ala Met Ser Glu Pro Asn Ala Gly Ser Asp Val Val Ser Met Lys Leu
    130                 135                 140                 
Arg Ala Asp Arg Val Gly Asp Arg Phe Val Leu Asn Gly Ser Lys Met
145                 150                 155                 160 
Trp Ile Thr Asn Gly Pro Asp Ala His Thr Tyr Val Ile Tyr Ala Lys
                165                 170                 175     
Thr Asp Ala Asp Lys Gly Ala His Gly Ile Thr Ala Phe Ile Val Glu
            180                 185                 190         
Arg Asp Trp Lys Gly Phe Ser Arg Gly Pro Lys Leu Asp Lys Leu Gly
        195                 200                 205             
Met Arg Gly Ser Asn Thr Cys Glu Leu Ile Phe Gln Asp Val Glu Val
    210                 215                 220                 
Pro Glu Glu Asn Val Leu Gly Ala Val Asn Gly Gly Val Lys Val Leu
225                 230                 235                 240 
Met Ser Gly Leu Asp Tyr Glu Arg Val Val Leu Ser Gly Gly Pro Val
                245                 250                 255     
Gly Ile Met Gln Ala Cys Met Asp Val Val Val Pro Tyr Ile His Asp
            260                 265                 270         
Arg Arg Gln Phe Gly Gln Ser Ile Gly Glu Phe Gln Leu Val Gln Gly
        275                 280                 285             
Lys Val Ala Asp Met Tyr Thr Ala Leu Asn Ala Ser Arg Ala Tyr Leu
    290                 295                 300                 
Tyr Ala Val Ala Ala Ala Cys Asp Arg Gly Glu Thr Thr Arg Lys Asp
305                 310                 315                 320 
Ala Ala Gly Val Ile Leu Tyr Ser Ala Glu Arg Ala Thr Gln Met Ala
                325                 330                 335     
Leu Asp Ala Ile Gln Ile Leu Gly Gly Asn Gly Tyr Ile Asn Glu Phe
            340                 345                 350         
Pro Thr Gly Arg Leu Leu Arg Asp Ala Lys Leu Tyr Glu Ile Gly Ala
        355                 360                 365             
Gly Thr Ser Glu Ile Arg Arg Met Leu Ile Gly Arg Glu Leu Phe Asn
    370                 375                 380                 
Glu Thr Arg
385         


<210> 12
<211> 386
<212> PRT
<213> Streptomyces avermitilis

<400> 12
Met Asp His Arg Leu Thr Pro Glu Leu Glu Glu Leu Arg Arg Thr Val
 1               5                  10                  15      
Glu Glu Phe Ala His Asp Val Val Ala Pro Lys Ile Gly Asp Phe Tyr
            20                  25                  30          
Glu Arg His Glu Phe Pro Tyr Glu Ile Val Arg Glu Met Gly Arg Met
        35                  40                  45              
Gly Leu Phe Gly Leu Pro Phe Pro Glu Glu Tyr Gly Gly Met Gly Gly
    50                  55                  60                  
Asp Tyr Leu Ala Leu Gly Ile Ala Leu Glu Glu Leu Ala Arg Val Asp
65                  70                  75                  80  
Ser Ser Val Ala Ile Thr Leu Glu Ala Gly Val Ser Leu Gly Ala Met
                85                  90                  95      
Pro Ile His Leu Phe Gly Thr Asp Ala Gln Lys Ala Glu Trp Leu Pro
            100                 105                 110         
Arg Leu Cys Ser Gly Glu Ile Leu Gly Ala Phe Gly Leu Thr Glu Pro
        115                 120                 125             
Asp Gly Gly Ser Asp Ala Gly Ala Thr Arg Thr Thr Ala Arg Leu Asp
    130                 135                 140                 
Glu Ser Thr Asn Glu Trp Val Ile Asn Gly Thr Lys Cys Phe Ile Thr
145                 150                 155                 160 
Asn Ser Gly Thr Asp Ile Thr Gly Leu Val Thr Val Thr Ala Val Thr
                165                 170                 175     
Gly Arg Lys Pro Asp Gly Lys Pro Leu Ile Ser Ser Ile Ile Val Pro
            180                 185                 190         
Ser Gly Thr Pro Gly Phe Thr Val Ala Ala Pro Tyr Ser Lys Val Gly
        195                 200                 205             
Trp Asn Ala Ser Asp Thr Arg Glu Leu Ser Phe Ala Asp Val Arg Val
    210                 215                 220                 
Pro Ala Ala Asn Leu Leu Gly Glu Gln Gly Arg Gly Tyr Ala Gln Phe
225                 230                 235                 240 
Leu Arg Ile Leu Asp Glu Gly Arg Ile Ala Ile Ser Ala Leu Ala Thr
                245                 250                 255     
Gly Leu Ala Gln Gly Cys Val Asp Glu Ser Val Lys Tyr Ala Gly Glu
            260                 265                 270         
Arg His Ala Phe Gly Arg Asn Ile Gly Ala Tyr Gln Ala Ile Gln Phe
        275                 280                 285             
Lys Ile Ala Asp Met Glu Met Lys Ala His Met Ala Arg Val Gly Trp
    290                 295                 300                 
Arg Asp Ala Ala Ser Arg Leu Val Ala Gly Glu Pro Phe Lys Lys Glu
305                 310                 315                 320 
Ala Ala Ile Ala Lys Leu Tyr Ser Ser Thr Val Ala Val Asp Asn Ala
                325                 330                 335     
Arg Glu Ala Thr Gln Ile His Gly Gly Tyr Gly Phe Met Asn Glu Tyr
            340                 345                 350         
Pro Val Ala Arg Met Trp Arg Asp Ser Lys Ile Leu Glu Ile Gly Glu
        355                 360                 365             
Gly Thr Ser Glu Val Gln Arg Met Leu Ile Ala Arg Glu Leu Gly Leu
    370                 375                 380                 
Val Gly
385     

