                         SEQUENCE LISTING

<110>  Pontificia Universidad Catolica de Chile et al
 
<120>  METHODS AND COMPOSITIONS FOR DIAGNOSING THYROID CANCER

<130>  BMRC-001/02WO

<150>  US 61/730,391
<151>  2012-11-27

<150>  US 61/775,419
<151>  2013-03-08

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  1670
<212>  DNA
<213>  Homo sapiens

<400>  1
ccaaccacaa gcaccaaagc agaggggcag gcagcacacc acccagcagc cagagcacca       60

gcccagccat ggtccttgag gtgagtgacc accaagtgct aaatgacgcc gaggttgccg      120

ccctcctgga gaacttcagc tcttcctatg actatggaga aaacgagagt gactcgtgct      180

gtacctcccc gccctgccca caggacttca gcctgaactt cgaccgggcc ttcctgccag      240

ccctctacag cctcctcttt ctgctggggc tgctgggcaa cggcgcggtg gcagccgtgc      300

tgctgagccg gcggacagcc ctgagcagca ccgacacctt cctgctccac ctagctgtag      360

cagacacgct gctggtgctg acactgccgc tctgggcagt ggacgctgcc gtccagtggg      420

tctttggctc tggcctctgc aaagtggcag gtgccctctt caacatcaac ttctacgcag      480

gagccctcct gctggcctgc atcagctttg accgctacct gaacatagtt catgccaccc      540

agctctaccg ccgggggccc ccggcccgcg tgaccctcac ctgcctggct gtctgggggc      600

tctgcctgct tttcgccctc ccagacttca tcttcctgtc ggcccaccac gacgagcgcc      660

tcaacgccac ccactgccaa tacaacttcc cacaggtggg ccgcacggct ctgcgggtgc      720

tgcagctggt ggctggcttt ctgctgcccc tgctggtcat ggcctactgc tatgcccaca      780

tcctggccgt gctgctggtt tccaggggcc agcggcgcct gcgggccatg cggctggtgg      840

tggtggtcgt ggtggccttt gccctctgct ggacccccta tcacctggtg gtgctggtgg      900

acatcctcat ggacctgggc gctttggccc gcaactgtgg ccgagaaagc agggtagacg      960

tggccaagtc ggtcacctca ggcctgggct acatgcactg ctgcctcaac ccgctgctct     1020

atgcctttgt aggggtcaag ttccgggagc ggatgtggat gctgctcttg cgcctgggct     1080

gccccaacca gagagggctc cagaggcagc catcgtcttc ccgccgggat tcatcctggt     1140

ctgagacctc agaggcctcc tactcgggct tgtgaggccg gaatccgggc tcccctttcg     1200

cccacagtct gacttccccg cattccaggc tcctccctcc ctctgccggc tctggctctc     1260

cccaatatcc tcgctcccgg gactcactgg cagccccagc accaccaggt ctcccgggaa     1320

gccaccctcc cagctctgag gactgcacca ttgctgctcc ttagctgcca agccccatcc     1380

tgccgcccga ggtggctgcc tggagcccca ctgcccttct catttggaaa ctaaaacttc     1440

atcttcccca agtgcgggga gtacaaggca tggcgtagag ggtgctgccc catgaagcca     1500

cagcccaggc ctccagctca gcagtgactg tggccatggt ccccaagacc tctatatttg     1560

ctcttttatt tttatgtcta aaatcctgct taaaactttt caataaacaa gatcgtcagg     1620

accaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                1670


<210>  2
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Leu Glu Val Ser Asp His Gln Val Leu Asn Asp Ala Glu Val 
1               5                   10                  15      


Ala Ala Leu Leu Glu Asn Phe Ser Ser Ser Tyr Asp Tyr Gly Glu Asn 
            20                  25                  30          


Glu Ser Asp Ser Cys Cys Thr Ser Pro Pro Cys Pro Gln Asp Phe Ser 
        35                  40                  45              


Leu Asn Phe Asp Arg Ala Phe Leu Pro Ala Leu Tyr Ser Leu Leu Phe 
    50                  55                  60                  


Leu Leu Gly Leu Leu Gly Asn Gly Ala Val Ala Ala Val Leu Leu Ser 
65                  70                  75                  80  


Arg Arg Thr Ala Leu Ser Ser Thr Asp Thr Phe Leu Leu His Leu Ala 
                85                  90                  95      


Val Ala Asp Thr Leu Leu Val Leu Thr Leu Pro Leu Trp Ala Val Asp 
            100                 105                 110         


Ala Ala Val Gln Trp Val Phe Gly Ser Gly Leu Cys Lys Val Ala Gly 
        115                 120                 125             


Ala Leu Phe Asn Ile Asn Phe Tyr Ala Gly Ala Leu Leu Leu Ala Cys 
    130                 135                 140                 


Ile Ser Phe Asp Arg Tyr Leu Asn Ile Val His Ala Thr Gln Leu Tyr 
145                 150                 155                 160 


Arg Arg Gly Pro Pro Ala Arg Val Thr Leu Thr Cys Leu Ala Val Trp 
                165                 170                 175     


Gly Leu Cys Leu Leu Phe Ala Leu Pro Asp Phe Ile Phe Leu Ser Ala 
            180                 185                 190         


His His Asp Glu Arg Leu Asn Ala Thr His Cys Gln Tyr Asn Phe Pro 
        195                 200                 205             


Gln Val Gly Arg Thr Ala Leu Arg Val Leu Gln Leu Val Ala Gly Phe 
    210                 215                 220                 


Leu Leu Pro Leu Leu Val Met Ala Tyr Cys Tyr Ala His Ile Leu Ala 
225                 230                 235                 240 


Val Leu Leu Val Ser Arg Gly Gln Arg Arg Leu Arg Ala Met Arg Leu 
                245                 250                 255     


Val Val Val Val Val Val Ala Phe Ala Leu Cys Trp Thr Pro Tyr His 
            260                 265                 270         


Leu Val Val Leu Val Asp Ile Leu Met Asp Leu Gly Ala Leu Ala Arg 
        275                 280                 285             


Asn Cys Gly Arg Glu Ser Arg Val Asp Val Ala Lys Ser Val Thr Ser 
    290                 295                 300                 


Gly Leu Gly Tyr Met His Cys Cys Leu Asn Pro Leu Leu Tyr Ala Phe 
305                 310                 315                 320 


Val Gly Val Lys Phe Arg Glu Arg Met Trp Met Leu Leu Leu Arg Leu 
                325                 330                 335     


Gly Cys Pro Asn Gln Arg Gly Leu Gln Arg Gln Pro Ser Ser Ser Arg 
            340                 345                 350         


Arg Asp Ser Ser Trp Ser Glu Thr Ser Glu Ala Ser Tyr Ser Gly Leu 
        355                 360                 365             


<210>  3
<211>  1796
<212>  DNA
<213>  Homo sapiens

<400>  3
ctgatggtat ctctgtttca ggagtggtga cgcctaagct atcactggac atatcaagga       60

cttcactaaa ttagcaggta ccactggtct tcttgtgctt atccgggcaa gaacttatcg      120

aaatacaata gaagttttta cttagaagag attttcagca gatgagaagc tggtaacaga      180

gaccaaaata gtttggagac taaagaatca ttgcacattt cactgctgag ttgtattgga      240

gaagtgaaat gacaacctca ctagatacag ttgagacctt tggtaccaca tcctactatg      300

atgacgtggg cctgctctgt gaaaaagctg ataccagagc actgatggcc cagtttgtgc      360

ccccgctgta ctccctggtg ttcactgtgg gcctcttggg caatgtggtg gtggtgatga      420

tcctcataaa atacaggagg ctccgaatta tgaccaacat ctacctgctc aacctggcca      480

tttcggacct gctcttcctc gtcacccttc cattctggat ccactatgtc agggggcata      540

actgggtttt tggccatggc atgtgtaagc tcctctcagg gttttatcac acaggcttgt      600

acagcgagat ctttttcata atcctgctga caatcgacag gtacctggcc attgtccatg      660

ctgtgtttgc ccttcgagcc cggactgtca cttttggtgt catcaccagc atcgtcacct      720

ggggcctggc agtgctagca gctcttcctg aatttatctt ctatgagact gaagagttgt      780

ttgaagagac tctttgcagt gctctttacc cagaggatac agtatatagc tggaggcatt      840

tccacactct gagaatgacc atcttctgtc tcgttctccc tctgctcgtt atggccatct      900

gctacacagg aatcatcaaa acgctgctga ggtgccccag taaaaaaaag tacaaggcca      960

tccggctcat ttttgtcatc atggcggtgt ttttcatttt ctggacaccc tacaatgtgg     1020

ctatccttct ctcttcctat caatccatct tatttggaaa tgactgtgag cggagcaagc     1080

atctggacct ggtcatgctg gtgacagagg tgatcgccta ctcccactgc tgcatgaacc     1140

cggtgatcta cgcctttgtt ggagagaggt tccggaagta cctgcgccac ttcttccaca     1200

ggcacttgct catgcacctg ggcagataca tcccattcct tcctagtgag aagctggaaa     1260

gaaccagctc tgtctctcca tccacagcag agccggaact ctctattgtg ttttaggtca     1320

gatgcagaaa attgcctaaa gaggaaggac caaggagatg aagcaaacac attaagcctt     1380

ccacactcac ctctaaaaca gtccttcaaa cttccagtgc aacactgaag ctcttgaaga     1440

cactgaaata tacacacagc agtagcagta gatgcatgta ccctaaggtc attaccacag     1500

gccaggggct gggcagcgta ctcatcatca accctaaaaa gcagagcttt gcttctctct     1560

ctaaaatgag ttacctacat tttaatgcac ctgaatgtta gatagttact atatgccgct     1620

acaaaaaggt aaaacttttt atattttata cattaacttc agccagctat tgatataaat     1680

aaaacatttt cacacaatac aataagttaa ctattttatt ttctaatgtg cctagttctt     1740

tccctgctta atgaaaagct tgttttttca gtgtgaataa ataatcgtaa gcaaca         1796


<210>  4
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Thr Thr Ser Leu Asp Thr Val Glu Thr Phe Gly Thr Thr Ser Tyr 
1               5                   10                  15      


Tyr Asp Asp Val Gly Leu Leu Cys Glu Lys Ala Asp Thr Arg Ala Leu 
            20                  25                  30          


Met Ala Gln Phe Val Pro Pro Leu Tyr Ser Leu Val Phe Thr Val Gly 
        35                  40                  45              


Leu Leu Gly Asn Val Val Val Val Met Ile Leu Ile Lys Tyr Arg Arg 
    50                  55                  60                  


Leu Arg Ile Met Thr Asn Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp 
65                  70                  75                  80  


Leu Leu Phe Leu Val Thr Leu Pro Phe Trp Ile His Tyr Val Arg Gly 
                85                  90                  95      


His Asn Trp Val Phe Gly His Gly Met Cys Lys Leu Leu Ser Gly Phe 
            100                 105                 110         


Tyr His Thr Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu Leu Thr 
        115                 120                 125             


Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu Arg Ala 
    130                 135                 140                 


Arg Thr Val Thr Phe Gly Val Ile Thr Ser Ile Val Thr Trp Gly Leu 
145                 150                 155                 160 


Ala Val Leu Ala Ala Leu Pro Glu Phe Ile Phe Tyr Glu Thr Glu Glu 
                165                 170                 175     


Leu Phe Glu Glu Thr Leu Cys Ser Ala Leu Tyr Pro Glu Asp Thr Val 
            180                 185                 190         


Tyr Ser Trp Arg His Phe His Thr Leu Arg Met Thr Ile Phe Cys Leu 
        195                 200                 205             


Val Leu Pro Leu Leu Val Met Ala Ile Cys Tyr Thr Gly Ile Ile Lys 
    210                 215                 220                 


Thr Leu Leu Arg Cys Pro Ser Lys Lys Lys Tyr Lys Ala Ile Arg Leu 
225                 230                 235                 240 


Ile Phe Val Ile Met Ala Val Phe Phe Ile Phe Trp Thr Pro Tyr Asn 
                245                 250                 255     


Val Ala Ile Leu Leu Ser Ser Tyr Gln Ser Ile Leu Phe Gly Asn Asp 
            260                 265                 270         


Cys Glu Arg Ser Lys His Leu Asp Leu Val Met Leu Val Thr Glu Val 
        275                 280                 285             


Ile Ala Tyr Ser His Cys Cys Met Asn Pro Val Ile Tyr Ala Phe Val 
    290                 295                 300                 


Gly Glu Arg Phe Arg Lys Tyr Leu Arg His Phe Phe His Arg His Leu 
305                 310                 315                 320 


Leu Met His Leu Gly Arg Tyr Ile Pro Phe Leu Pro Ser Glu Lys Leu 
                325                 330                 335     


Glu Arg Thr Ser Ser Val Ser Pro Ser Thr Ala Glu Pro Glu Leu Ser 
            340                 345                 350         


Ile Val Phe 
        355 


<210>  5
<211>  1227
<212>  DNA
<213>  Homo sapiens

<400>  5
ctttgcagat aaatatggca cactagcccc acgttttctg agacattcct caattgctta       60

gacatattct gagcctacag cagaggaacc tccagtctca gcaccatgaa tcaaactgcc      120

attctgattt gctgccttat ctttctgact ctaagtggca ttcaaggagt acctctctct      180

agaactgtac gctgtacctg catcagcatt agtaatcaac ctgttaatcc aaggtcttta      240

gaaaaacttg aaattattcc tgcaagccaa ttttgtccac gtgttgagat cattgctaca      300

atgaaaaaga agggtgagaa gagatgtctg aatccagaat cgaaggccat caagaattta      360

ctgaaagcag ttagcaagga aaggtctaaa agatctcctt aaaaccagag gggagcaaaa      420

tcgatgcagt gcttccaagg atggaccaca cagaggctgc ctctcccatc acttccctac      480

atggagtata tgtcaagcca taattgttct tagtttgcag ttacactaaa aggtgaccaa      540

tgatggtcac caaatcagct gctactactc ctgtaggaag gttaatgttc atcatcctaa      600

gctattcagt aataactcta ccctggcact ataatgtaag ctctactgag gtgctatgtt      660

cttagtggat gttctgaccc tgcttcaaat atttccctca cctttcccat cttccaaggg      720

tactaaggaa tctttctgct ttggggttta tcagaattct cagaatctca aataactaaa      780

aggtatgcaa tcaaatctgc tttttaaaga atgctcttta cttcatggac ttccactgcc      840

atcctcccaa ggggcccaaa ttctttcagt ggctacctac atacaattcc aaacacatac      900

aggaaggtag aaatatctga aaatgtatgt gtaagtattc ttatttaatg aaagactgta      960

caaagtagaa gtcttagatg tatatatttc ctatattgtt ttcagtgtac atggaataac     1020

atgtaattaa gtactatgta tcaatgagta acaggaaaat tttaaaaata cagatagata     1080

tatgctctgc atgttacata agataaatgt gctgaatggt tttcaaaata aaaatgaggt     1140

actctcctgg aaatattaag aaagactatc taaatgttga aagatcaaaa ggttaataaa     1200

gtaattataa ctaagaaaaa aaaaaaa                                         1227


<210>  6
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu 
1               5                   10                  15      


Ser Gly Ile Gln Gly Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys 
            20                  25                  30          


Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys Arg 
                85                  90                  95      


Ser Pro 
        


<210>  7
<211>  1490
<212>  DNA
<213>  Homo sapiens

<400>  7
agatatccgc ccctgacacc attcctccct tcccccctcc accggccgcg ggcataaaag       60

gcgccaggtg agggcctcgc cgctcctccc gcgaatcgca gcttctgaga ccagggttgc      120

tccgtccgtg ctccgcctcg ccatgacttc ctacagctat cgccagtcgt cggccacgtc      180

gtccttcgga ggcctgggcg gcggctccgt gcgttttggg ccgggggtcg cctttcgcgc      240

gcccagcatt cacgggggct ccggcggccg cggcgtatcc gtgtcctccg cccgctttgt      300

gtcctcgtcc tcctcggggg cctacggcgg cggctacggc ggcgtcctga ccgcgtccga      360

cgggctgctg gcgggcaacg agaagctaac catgcagaac ctcaacgacc gcctggcctc      420

ctacctggac aaggtgcgcg ccctggaggc ggccaacggc gagctagagg tgaagatccg      480

cgactggtac cagaagcagg ggcctgggcc ctcccgcgac tacagccact actacacgac      540

catccaggac ctgcgggaca agattcttgg tgccaccatt gagaactcca ggattgtcct      600

gcagatcgac aatgcccgtc tggctgcaga tgacttccga accaagtttg agacggaaca      660

ggctctgcgc atgagcgtgg aggccgacat caacggcctg cgcagggtgc tggatgagct      720

gaccctggcc aggaccgacc tggagatgca gatcgaaggc ctgaaggaag agctggccta      780

cctgaagaag aaccatgagg aggaaatcag tacgctgagg ggccaagtgg gaggccaggt      840

cagtgtggag gtggattccg ctccgggcac cgatctcgcc aagatcctga gtgacatgcg      900

aagccaatat gaggtcatgg ccgagcagaa ccggaaggat gctgaagcct ggttcaccag      960

ccggactgaa gaattgaacc gggaggtcgc tggccacacg gagcagctcc agatgagcag     1020

gtccgaggtt actgacctgc ggcgcaccct tcagggtctt gagattgagc tgcagtcaca     1080

gctgagcatg aaagctgcct tggaagacac actggcagaa acggaggcgc gctttggagc     1140

ccagctggcg catatccagg cgctgatcag cggtattgaa gcccagctgg gcgatgtgcg     1200

agctgatagt gagcggcaga atcaggagta ccagcggctc atggacatca agtcgcggct     1260

ggagcaggag attgccacct accgcagcct gctcgaggga caggaagatc actacaacaa     1320

tttgtctgcc tccaaggtcc tctgaggcag caggctctgg ggcttctgct gtcctttgga     1380

gggtgtcttc tgggtagagg gatgggaagg aagggaccct tacccccggc tcttctcctg     1440

acctgccaat aaaaatttat ggtccaaggg aaaaaaaaaa aaaaaaaaaa                1490


<210>  8
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Thr Ser Tyr Ser Tyr Arg Gln Ser Ser Ala Thr Ser Ser Phe Gly 
1               5                   10                  15      


Gly Leu Gly Gly Gly Ser Val Arg Phe Gly Pro Gly Val Ala Phe Arg 
            20                  25                  30          


Ala Pro Ser Ile His Gly Gly Ser Gly Gly Arg Gly Val Ser Val Ser 
        35                  40                  45              


Ser Ala Arg Phe Val Ser Ser Ser Ser Ser Gly Ala Tyr Gly Gly Gly 
    50                  55                  60                  


Tyr Gly Gly Val Leu Thr Ala Ser Asp Gly Leu Leu Ala Gly Asn Glu 
65                  70                  75                  80  


Lys Leu Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser Tyr Leu Asp 
                85                  90                  95      


Lys Val Arg Ala Leu Glu Ala Ala Asn Gly Glu Leu Glu Val Lys Ile 
            100                 105                 110         


Arg Asp Trp Tyr Gln Lys Gln Gly Pro Gly Pro Ser Arg Asp Tyr Ser 
        115                 120                 125             


His Tyr Tyr Thr Thr Ile Gln Asp Leu Arg Asp Lys Ile Leu Gly Ala 
    130                 135                 140                 


Thr Ile Glu Asn Ser Arg Ile Val Leu Gln Ile Asp Asn Ala Arg Leu 
145                 150                 155                 160 


Ala Ala Asp Asp Phe Arg Thr Lys Phe Glu Thr Glu Gln Ala Leu Arg 
                165                 170                 175     


Met Ser Val Glu Ala Asp Ile Asn Gly Leu Arg Arg Val Leu Asp Glu 
            180                 185                 190         


Leu Thr Leu Ala Arg Thr Asp Leu Glu Met Gln Ile Glu Gly Leu Lys 
        195                 200                 205             


Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu Glu Glu Ile Ser Thr 
    210                 215                 220                 


Leu Arg Gly Gln Val Gly Gly Gln Val Ser Val Glu Val Asp Ser Ala 
225                 230                 235                 240 


Pro Gly Thr Asp Leu Ala Lys Ile Leu Ser Asp Met Arg Ser Gln Tyr 
                245                 250                 255     


Glu Val Met Ala Glu Gln Asn Arg Lys Asp Ala Glu Ala Trp Phe Thr 
            260                 265                 270         


Ser Arg Thr Glu Glu Leu Asn Arg Glu Val Ala Gly His Thr Glu Gln 
        275                 280                 285             


Leu Gln Met Ser Arg Ser Glu Val Thr Asp Leu Arg Arg Thr Leu Gln 
    290                 295                 300                 


Gly Leu Glu Ile Glu Leu Gln Ser Gln Leu Ser Met Lys Ala Ala Leu 
305                 310                 315                 320 


Glu Asp Thr Leu Ala Glu Thr Glu Ala Arg Phe Gly Ala Gln Leu Ala 
                325                 330                 335     


His Ile Gln Ala Leu Ile Ser Gly Ile Glu Ala Gln Leu Gly Asp Val 
            340                 345                 350         


Arg Ala Asp Ser Glu Arg Gln Asn Gln Glu Tyr Gln Arg Leu Met Asp 
        355                 360                 365             


Ile Lys Ser Arg Leu Glu Gln Glu Ile Ala Thr Tyr Arg Ser Leu Leu 
    370                 375                 380                 


Glu Gly Gln Glu Asp His Tyr Asn Asn Leu Ser Ala Ser Lys Val Leu 
385                 390                 395                 400 


<210>  9
<211>  931
<212>  DNA
<213>  Homo sapiens

<400>  9
tttcgtcggc ccgccccttg gcttctgcac tgatggtggg tggatgagta atgcatccag       60

gaagcctgga ggcctgtggt ttccgcaccc gctgccaccc ccgcccctag cgtggacatt      120

tatcctctag cgctcaggcc ctgccgccat cgccgcagat ccagcgccca gagagacacc      180

agagaaccca ccatggcccc ctttgagccc ctggcttctg gcatcctgtt gttgctgtgg      240

ctgatagccc ccagcagggc ctgcacctgt gtcccacccc acccacagac ggccttctgc      300

aattccgacc tcgtcatcag ggccaagttc gtggggacac cagaagtcaa ccagaccacc      360

ttataccagc gttatgagat caagatgacc aagatgtata aagggttcca agccttaggg      420

gatgccgctg acatccggtt cgtctacacc cccgccatgg agagtgtctg cggatacttc      480

cacaggtccc acaaccgcag cgaggagttt ctcattgctg gaaaactgca ggatggactc      540

ttgcacatca ctacctgcag ttttgtggct ccctggaaca gcctgagctt agctcagcgc      600

cggggcttca ccaagaccta cactgttggc tgtgaggaat gcacagtgtt tccctgttta      660

tccatcccct gcaaactgca gagtggcact cattgcttgt ggacggacca gctcctccaa      720

ggctctgaaa agggcttcca gtcccgtcac cttgcctgcc tgcctcggga gccagggctg      780

tgcacctggc agtccctgcg gtcccagata gcctgaatcc tgcccggagt ggaagctgaa      840

gcctgcacag tgtccaccct gttcccactc ccatctttct tccggacaat gaaataaaga      900

gttaccaccc agcagaaaaa aaaaaaaaaa a                                     931


<210>  10
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Pro Phe Glu Pro Leu Ala Ser Gly Ile Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ile Ala Pro Ser Arg Ala Cys Thr Cys Val Pro Pro His Pro Gln 
            20                  25                  30          


Thr Ala Phe Cys Asn Ser Asp Leu Val Ile Arg Ala Lys Phe Val Gly 
        35                  40                  45              


Thr Pro Glu Val Asn Gln Thr Thr Leu Tyr Gln Arg Tyr Glu Ile Lys 
    50                  55                  60                  


Met Thr Lys Met Tyr Lys Gly Phe Gln Ala Leu Gly Asp Ala Ala Asp 
65                  70                  75                  80  


Ile Arg Phe Val Tyr Thr Pro Ala Met Glu Ser Val Cys Gly Tyr Phe 
                85                  90                  95      


His Arg Ser His Asn Arg Ser Glu Glu Phe Leu Ile Ala Gly Lys Leu 
            100                 105                 110         


Gln Asp Gly Leu Leu His Ile Thr Thr Cys Ser Phe Val Ala Pro Trp 
        115                 120                 125             


Asn Ser Leu Ser Leu Ala Gln Arg Arg Gly Phe Thr Lys Thr Tyr Thr 
    130                 135                 140                 


Val Gly Cys Glu Glu Cys Thr Val Phe Pro Cys Leu Ser Ile Pro Cys 
145                 150                 155                 160 


Lys Leu Gln Ser Gly Thr His Cys Leu Trp Thr Asp Gln Leu Leu Gln 
                165                 170                 175     


Gly Ser Glu Lys Gly Phe Gln Ser Arg His Leu Ala Cys Leu Pro Arg 
            180                 185                 190         


Glu Pro Gly Leu Cys Thr Trp Gln Ser Leu Arg Ser Gln Ile Ala 
        195                 200                 205         


<210>  11
<211>  3452
<212>  DNA
<213>  Homo sapiens

<400>  11
gtctcagttc ccgagcctgg gagcaaccgc agcttctagt atccagactc cagcgccgcc       60

ccgggcgcgg accccaaccc cgacccagag cttctccagc ggcggcgcag cgagcagggc      120

tccccgcctt aacttcctcc gcggggccca gccaccttcg ggagtccggg ttgcccacct      180

gcaaactctc cgccttctgc acctgccacc cctgagccag cgcgggcgcc cgagcgagtc      240

atggccaacg cggggctgca gctgttgggc ttcattctcg ccttcctggg atggatcggc      300

gccatcgtca gcactgccct gccccagtgg aggatttact cctatgccgg cgacaacatc      360

gtgaccgccc aggccatgta cgaggggctg tggatgtcct gcgtgtcgca gagcaccggg      420

cagatccagt gcaaagtctt tgactccttg ctgaatctga gcagcacatt gcaagcaacc      480

cgtgccttga tggtggttgg catcctcctg ggagtgatag caatctttgt ggccaccgtt      540

ggcatgaagt gtatgaagtg cttggaagac gatgaggtgc agaagatgag gatggctgtc      600

attgggggtg cgatatttct tcttgcaggt ctggctattt tagttgccac agcatggtat      660

ggcaatagaa tcgttcaaga attctatgac cctatgaccc cagtcaatgc caggtacgaa      720

tttggtcagg ctctcttcac tggctgggct gctgcttctc tctgccttct gggaggtgcc      780

ctactttgct gttcctgtcc ccgaaaaaca acctcttacc caacaccaag gccctatcca      840

aaacctgcac cttccagcgg gaaagactac gtgtgacaca gaggcaaaag gagaaaatca      900

tgttgaaaca aaccgaaaat ggacattgag atactatcat taacattagg accttagaat      960

tttgggtatt gtaatctgaa gtatggtatt acaaaacaaa caaacaaaca aaaaacccat     1020

gtgttaaaat actcagtgct aaacatggct taatcttatt ttatcttctt tcctcaatat     1080

aggagggaag atttttccat ttgtattact gcttcccatt gagtaatcat actcaactgg     1140

gggaaggggt gctccttaaa tatatataga tatgtatata tacatgtttt tctattaaaa     1200

atagacagta aaatactatt ctcattatgt tgatactagc atacttaaaa tatctctaaa     1260

ataggtaaat gtatttaatt ccatattgat gaagatgttt attggtatat tttctttttc     1320

gtctatatat acatatgtaa cagtcaaata tcatttactc ttcttcatta gctttgggtg     1380

cctttgccac aagacctagc ctaatttacc aaggatgaat tctttcaatt cttcatgcgt     1440

gcccttttca tatacttatt ttatttttta ccataatctt atagcacttg catcgttatt     1500

aagcccttat ttgttttgtg tttcattggt ctctatctcc tgaatctaac acatttcata     1560

gcctacattt tagtttctaa agccaagaag aatttattac aaatcagaac tttggaggca     1620

aatctttctg catgaccaaa gtgataaatt cctgttgacc ttcccacaca atccctgtac     1680

tctgacccat agcactcttg tttgctttga aaatatttgt ccaattgagt agctgcatgc     1740

tgttccccca ggtgttgtaa cacaacttta ttgattgaat ttttaagcta cttattcata     1800

gttttatatc cccctaaact acctttttgt tccccattcc ttaattgtat tgttttccca     1860

agtgtaatta tcatgcgttt tatatcttcc taataaggtg tggtctgttt gtctgaacaa     1920

agtgctagac tttctggagt gataatctgg tgacaaatat tctctctgta gctgtaagca     1980

agtcacttaa tctttctacc tcttttttct atctgccaaa ttgagataat gatacttaac     2040

cagttagaag aggtagtgtg aatattaatt agtttatatt actctcattc tttgaacatg     2100

aactatgcct atgtagtgtc tttatttgct cagctggctg agacactgaa gaagtcactg     2160

aacaaaacct acacacgtac cttcatgtga ttcactgcct tcctctctct accagtctat     2220

ttccactgaa caaaacctac acacatacct tcatgtggtt cagtgccttc ctctctctac     2280

cagtctattt ccactgaaca aaacctacgc acataccttc atgtggctca gtgccttcct     2340

ctctctacca gtctatttcc attctttcag ctgtgtctga catgtttgtg ctctgttcca     2400

ttttaacaac tgctcttact tttccagtct gtacagaatg ctatttcact tgagcaagat     2460

gatgtaatgg aaagggtgtt ggcattggtg tctggagacc tggatttgag tcttggtgct     2520

atcaatcacc gtctgtgttt gagcaaggca tttggctgct gtaagcttat tgcttcatct     2580

gtaagcggtg gtttgtaatt cctgatcttc ccacctcaca gtgatgttgt ggggatccag     2640

tgagatagaa tacatgtaag tgtggttttg taatttaaaa agtgctatac taagggaaag     2700

aattgaggaa ttaactgcat acgttttggt gttgcttttc aaatgtttga aaacaaaaaa     2760

aatgttaaga aatgggtttc ttgccttaac cagtctctca agtgatgaga cagtgaagta     2820

aaattgagtg cactaaacaa ataagattct gaggaagtct tatcttctgc agtgagtatg     2880

gcccgatgct ttctgtggct aaacagatgt aatgggaaga aataaaagcc tacgtgttgg     2940

taaatccaac agcaagggag atttttgaat cataataact cataaggtgc tatctgttca     3000

gtgatgccct cagagctctt gctgttagct ggcagctgac gctgctagga tagttagttt     3060

ggaaatggta cttcataata aactacacaa ggaaagtcag ccactgtgtc ttatgaggaa     3120

ttggacctaa taaattttag tgtgccttcc aaacctgaga atatatgctt ttggaagtta     3180

aaatttaaat ggcttttgcc acatacatag atcttcatga tgtgtgagtg taattccatg     3240

tggatatcag ttaccaaaca ttacaaaaaa attttatggc ccaaaatgac caacgaaatt     3300

gttacaatag aatttatcca attttgatct ttttatattc ttctaccaca cctggaaaca     3360

gaccaataga cattttgggg ttttataata ggaatttgta taaagcatta ctctttttca     3420

ataaattgtt ttttaattta aaaaaaggat ta                                   3452


<210>  12
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Asn Ala Gly Leu Gln Leu Leu Gly Phe Ile Leu Ala Phe Leu 
1               5                   10                  15      


Gly Trp Ile Gly Ala Ile Val Ser Thr Ala Leu Pro Gln Trp Arg Ile 
            20                  25                  30          


Tyr Ser Tyr Ala Gly Asp Asn Ile Val Thr Ala Gln Ala Met Tyr Glu 
        35                  40                  45              


Gly Leu Trp Met Ser Cys Val Ser Gln Ser Thr Gly Gln Ile Gln Cys 
    50                  55                  60                  


Lys Val Phe Asp Ser Leu Leu Asn Leu Ser Ser Thr Leu Gln Ala Thr 
65                  70                  75                  80  


Arg Ala Leu Met Val Val Gly Ile Leu Leu Gly Val Ile Ala Ile Phe 
                85                  90                  95      


Val Ala Thr Val Gly Met Lys Cys Met Lys Cys Leu Glu Asp Asp Glu 
            100                 105                 110         


Val Gln Lys Met Arg Met Ala Val Ile Gly Gly Ala Ile Phe Leu Leu 
        115                 120                 125             


Ala Gly Leu Ala Ile Leu Val Ala Thr Ala Trp Tyr Gly Asn Arg Ile 
    130                 135                 140                 


Val Gln Glu Phe Tyr Asp Pro Met Thr Pro Val Asn Ala Arg Tyr Glu 
145                 150                 155                 160 


Phe Gly Gln Ala Leu Phe Thr Gly Trp Ala Ala Ala Ser Leu Cys Leu 
                165                 170                 175     


Leu Gly Gly Ala Leu Leu Cys Cys Ser Cys Pro Arg Lys Thr Thr Ser 
            180                 185                 190         


Tyr Pro Thr Pro Arg Pro Tyr Pro Lys Pro Ala Pro Ser Ser Gly Lys 
        195                 200                 205             


Asp Tyr Val 
    210     


<210>  13
<211>  1669
<212>  DNA
<213>  Homo sapiens

<400>  13
ggcaacccca cgcggctgga gaagccggcg ctcgcagccc ggcccgggcc gctgccggaa       60

gtgacgcgag ttcacctgcc gagcgggggc tgggaggagg ggcggagggt gcagaggtgc      120

cgccgccgcc gcgagccagt cgggagcgcg cgaggcgcgg ggagcctggg accaggagcg      180

agagccgcct acctgcagcc gccgcccacg gcacggcagc caccatggcg ctcctgctgt      240

gcttcgtgct cctgtgcgga gtagtggatt tcgccagaag tttgagtatc actactcctg      300

aagagatgat tgaaaaagcc aaaggggaaa ctgcctatct gccatgcaaa tttacgctta      360

gtcccgaaga ccagggaccg ctggacatcg agtggctgat atcaccagct gataatcaga      420

aggtggatca agtgattatt ttatattctg gagacaaaat ttatgatgac tactatccag      480

atctgaaagg ccgagtacat tttacgagta atgatctcaa atctggtgat gcatcaataa      540

atgtaacgaa tttacaactg tcagatattg gcacatatca gtgcaaagtg aaaaaagctc      600

ctggtgttgc aaataagaag attcatctgg tagttcttgt taagccttca ggtgcgagat      660

gttacgttga tggatctgaa gaaattggaa gtgactttaa gataaaatgt gaaccaaaag      720

aaggttcact tccattacag tatgagtggc aaaaattgtc tgactcacag aaaatgccca      780

cttcatggtt agcagaaatg acttcatctg ttatatctgt aaaaaatgcc tcttctgagt      840

actctgggac atacagctgt acagtcagaa acagagtggg ctctgatcag tgcctgttgc      900

gtctaaacgt tgtccctcct tcaaataaag ctggactaat tgcaggagcc attataggaa      960

ctttgcttgc tctagcgctc attggtctta tcatcttttg ctgtcgtaaa aagcgcagag     1020

aagaaaaata tgaaaaggaa gttcatcacg atatcaggga agatgtgcca cctccaaaga     1080

gccgtacgtc cactgccaga agctacatcg gcagtaatca ttcatccctg gggtccatgt     1140

ctccttccaa catggaagga tattccaaga ctcagtataa ccaagtacca agtgaagact     1200

ttgaacgcac tcctcagagt ccgactctcc cacctgctaa gttcaagtac ccttacaaga     1260

ctgatggaat tacagttgta taaatatgga ctactgaaga atctgaagta ttgtattatt     1320

tgactttatt ttaggcctct agtaaagact taaatgtttt ttaaaaaaag cacaaggcac     1380

agagattaga gcagctgtaa gaacacatct actttatgca atggcattag acatgtaagt     1440

cagatgtcat gtcaaaatta gtacgagcca aattctttgt taaaaaaccc tatgtatagt     1500

gacactgata gttaaaagat gttttattat attttcaata actaccacta acaaattttt     1560

aacttttcat atgcatattc tgatatgtgg tcttttagga aaagtatggt taatagttga     1620

tttttcaaag gaaattttaa aattcttacg ttctgtttaa tgtttttgc                 1669


<210>  14
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Leu Leu Leu Cys Phe Val Leu Leu Cys Gly Val Val Asp Phe 
1               5                   10                  15      


Ala Arg Ser Leu Ser Ile Thr Thr Pro Glu Glu Met Ile Glu Lys Ala 
            20                  25                  30          


Lys Gly Glu Thr Ala Tyr Leu Pro Cys Lys Phe Thr Leu Ser Pro Glu 
        35                  40                  45              


Asp Gln Gly Pro Leu Asp Ile Glu Trp Leu Ile Ser Pro Ala Asp Asn 
    50                  55                  60                  


Gln Lys Val Asp Gln Val Ile Ile Leu Tyr Ser Gly Asp Lys Ile Tyr 
65                  70                  75                  80  


Asp Asp Tyr Tyr Pro Asp Leu Lys Gly Arg Val His Phe Thr Ser Asn 
                85                  90                  95      


Asp Leu Lys Ser Gly Asp Ala Ser Ile Asn Val Thr Asn Leu Gln Leu 
            100                 105                 110         


Ser Asp Ile Gly Thr Tyr Gln Cys Lys Val Lys Lys Ala Pro Gly Val 
        115                 120                 125             


Ala Asn Lys Lys Ile His Leu Val Val Leu Val Lys Pro Ser Gly Ala 
    130                 135                 140                 


Arg Cys Tyr Val Asp Gly Ser Glu Glu Ile Gly Ser Asp Phe Lys Ile 
145                 150                 155                 160 


Lys Cys Glu Pro Lys Glu Gly Ser Leu Pro Leu Gln Tyr Glu Trp Gln 
                165                 170                 175     


Lys Leu Ser Asp Ser Gln Lys Met Pro Thr Ser Trp Leu Ala Glu Met 
            180                 185                 190         


Thr Ser Ser Val Ile Ser Val Lys Asn Ala Ser Ser Glu Tyr Ser Gly 
        195                 200                 205             


Thr Tyr Ser Cys Thr Val Arg Asn Arg Val Gly Ser Asp Gln Cys Leu 
    210                 215                 220                 


Leu Arg Leu Asn Val Val Pro Pro Ser Asn Lys Ala Gly Leu Ile Ala 
225                 230                 235                 240 


Gly Ala Ile Ile Gly Thr Leu Leu Ala Leu Ala Leu Ile Gly Leu Ile 
                245                 250                 255     


Ile Phe Cys Cys Arg Lys Lys Arg Arg Glu Glu Lys Tyr Glu Lys Glu 
            260                 265                 270         


Val His His Asp Ile Arg Glu Asp Val Pro Pro Pro Lys Ser Arg Thr 
        275                 280                 285             


Ser Thr Ala Arg Ser Tyr Ile Gly Ser Asn His Ser Ser Leu Gly Ser 
    290                 295                 300                 


Met Ser Pro Ser Asn Met Glu Gly Tyr Ser Lys Thr Gln Tyr Asn Gln 
305                 310                 315                 320 


Val Pro Ser Glu Asp Phe Glu Arg Thr Pro Gln Ser Pro Thr Leu Pro 
                325                 330                 335     


Pro Ala Lys Phe Lys Tyr Pro Tyr Lys Thr Asp Gly Ile Thr Val Val 
            340                 345                 350         


<210>  15
<211>  3997
<212>  DNA
<213>  Homo sapiens

<400>  15
gtgccaaggc ggctgggggc ggcgagcggg gccgcgggcg cgcaccgact caagagccga       60

ctgtcagcct cggcgggccg gagttctccg gcgctgggac aggggcgctg ggacaggggc      120

gctgggggcg agccctggcg ggggccaggt ccgaggaccc tgggcgcggc ggccccgcca      180

ggaggtccgg ccgcgagcgt gacctcacgg ggaggggcca gcgcggcggc ctgggcgctg      240

agccgagcgc cgggagagca gcgcagaagc cgagccgcga ggagcgcact ccgtggcccc      300

gatggagcgg tacaaagccc tggaacagct gctgacagag ttggatgact tcctcaagat      360

tcttgaccag gagaacctga gcagcacagc actggtgaag aagagctgcc tggcggagct      420

cctccggctt tacaccaaaa gcagcagctc tgatgaggag tacatttata tgaacaaagt      480

gaccatcaac aagcaacaga atgcagagtc tcaaggcaaa gcgcctgagg agcagggcct      540

gctacccaat ggggagccca gccagcactc ctcggcccct cagaagagcc ttccagacct      600

cccgccaccc aagatgattc cagaacggaa acagcttgcc atcccaaaga cggagtctcc      660

agagggctac tatgaagagg ctgagccata tgacacatcc ctcaatgagg acggagaggc      720

tgtgagcagc tcctacgagt cctacgatga agaggacggc agcaagggca agtcggcccc      780

ttaccagtgg ccctcgccgg aggccggcat cgagctgatg cgtgacgccc gcatctgcgc      840

cttcctgtgg cgcaagaagt ggctgggaca gtgggccaag cagctctgtg tcatcaagga      900

caacaggctt ctgtgctaca aatcctccaa ggaccacagc cctcagctgg acgtgaacct      960

actgggcagc agcgtcattc acaaggagaa gcaagtgcgg aagaaggagc acaagctgaa     1020

gatcacaccg atgaatgccg atgtgattgt gctgggcctg cagagcaagg accaggctga     1080

gcagtggctc agggtcatcc aggaagtgag cggcctgcct tccgaaggag catctgaagg     1140

aaaccagtac accccggatg cccagcgctt taactgccag aaaccagata tagctgagaa     1200

gtacctgtcg gcttcagagt atgggagctc cgtggatggc caccctgagg tcccagaaac     1260

caaagacgtc aagaagaaat gttctgctgg cctcaaactg agcaacctaa tgaatctggg     1320

caggaagaaa tccacctcac tggagcctgt ggagaggtcc ctcgagacat ccagttacct     1380

gaacgtgctg gtgaacagcc agtggaagtc tcgctggtgc tctgtcaggg acaatcacct     1440

gcacttctac caggaccgga accggagcaa ggtggcccag caacccctca gcctggtggg     1500

ctgcgaggtg gtcccagacc ccagccccga ccacctctac tccttccgca tcctccacaa     1560

gggcgaggag ctggccaagc ttgaggccaa gtcttccgag gaaatgggcc actggctggg     1620

tctcctgctc tctgagtcag gctccaagac agacccagaa gagttcacct acgactatgt     1680

ggatgccgat agggtctcct gtattgtgag tgcggccaaa aactctctct tactgatgca     1740

gagaaagttc tcagagccca acacttacat cgatggcctg cctagccagg accgccagga     1800

ggagctgtat gacgacgtgg acctgtcaga gctcacagct gcggtggagc ctaccgagga     1860

agccacccct gttgcagatg acccaaatga gagagaatct gaccgagtgt acctggacct     1920

cacacctgtc aagtcctttc tgcatggccc cagcagtgca caggcccagg cctcctcccc     1980

gacgttgtcc tgcctggaca atgcaactga ggccctcccg gcagactcag gcccaggtcc     2040

caccccagat gagccctgca taaagtgtcc agagaacctg ggagaacagc agctggagag     2100

tttggagcca gaggatcctt ccctgagaat caccaccgtc aaaatccaga cggaacagca     2160

gagaatctcc ttcccaccga gctgcccgga tgccgtggtg gccaccccac ctggtgccag     2220

cccacctgtg aaggacaggt tgcgcgtgac cagtgcagag atcaagcttg gcaagaatcg     2280

gacagaagct gaggtgaagc ggtacacaga ggagaaggag aggcttgaaa agaagaagga     2340

agaaatccgg gggcacctgg ctcagctccg gaaagagaaa cgggagctaa aggaaaccct     2400

actgaaatgc acagacaagg aagtcctggc gagcctggag cagaagctga aggaaattga     2460

cgaggagtgc cggggcgagg agagcaggcg cgtggacctg gagctcagca tcatggaggt     2520

gaaggacaac ctgaagaagg ctgaggcagg gcctgtgacg ttaggcacca ccgtggacac     2580

cacccacctg gagaatgtga gcccccgccc caaagctgtc acacctgcct ctgccccaga     2640

ctgtacccca gtcaactctg caaccacact caagaacagg cctctctcgg tcgtggtcac     2700

aggcaaaggc actgtactcc agaaagccaa ggaatgggag aagaaaggag caagttagaa     2760

aacaagcttc atctaaagac tctcatgtca atgtggacct tggtgacaat cctgctttgt     2820

taaagcaaaa actatgcgaa agggtgagtc tgtttagaag aaaaagcaaa gactgaggta     2880

ctgtgaatgg agagcttcag ctaagaggag gctctgtccc ttttcagagc caaaggaaat     2940

aatacaacaa aaaggaggct tctttggaga cctaagtcta ttggatgtaa acaagacgtt     3000

gtatttaggg atgttctgtg tttctttctt ttttgaagtt gtcatcaatt gctttactaa     3060

gatttttaaa tagtgaaaac ctcctgttta gactttggtg gaagatgaat caaggaagca     3120

gggccctgtc ttatgggtca cgtgtctttg gtgagtgaga agacctaaac tcctggccat     3180

catctcttat ccaatactta gcagttgggg attaaaccat ccttgccttc agttctctcc     3240

aatattacca ggcccaactc agtcttcagt gattttaaac agcattgaca tcatctgtaa     3300

aaccatcatc tgtaaaacca tctatgacat gagttttgag aaacaataat ggggaaaata     3360

tttgggacca agctgaagca ctaatcccac taagttaaag acttctttcc agtccaaggc     3420

aggcctgaat caactgtctt taaataaaat tttaagtgat gctgtattat atataggaaa     3480

aaatgcttaa aatcctgtca tttagaacag tgaaaagtat cttttgagat taaagtgact     3540

ctttactgta ggaaaaatat tactctgtgt ttacagattc attgctgtgg tcaggccatt     3600

tttaagggaa gagttattta atataaatag tctctgattt taagttctgt ttaatgttca     3660

ttctccttcc aagaacaaag tggtgatttt tggttagggt gatcgccctc ttaaaattgg     3720

cagtgctgtt ccttgtgctg cccctgtctt ttcctctgat ggcatttttt tttttttttt     3780

tttaacacag gttgaaacat ttcatctatt atctctgcct catttctgga gggttgtgta     3840

tcagttctct aacacttgtt cctgagaact aaatgtcttt tttattctta tttcctctct     3900

cataaacatt tggtgacctt ttaccaagtg gtgagttagt taggtttttt aaaataaaat     3960

gttcattgta tttgaaaaaa aaaaaaaaaa aaaaaaa                              3997


<210>  16
<211>  818
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Glu Arg Tyr Lys Ala Leu Glu Gln Leu Leu Thr Glu Leu Asp Asp 
1               5                   10                  15      


Phe Leu Lys Ile Leu Asp Gln Glu Asn Leu Ser Ser Thr Ala Leu Val 
            20                  25                  30          


Lys Lys Ser Cys Leu Ala Glu Leu Leu Arg Leu Tyr Thr Lys Ser Ser 
        35                  40                  45              


Ser Ser Asp Glu Glu Tyr Ile Tyr Met Asn Lys Val Thr Ile Asn Lys 
    50                  55                  60                  


Gln Gln Asn Ala Glu Ser Gln Gly Lys Ala Pro Glu Glu Gln Gly Leu 
65                  70                  75                  80  


Leu Pro Asn Gly Glu Pro Ser Gln His Ser Ser Ala Pro Gln Lys Ser 
                85                  90                  95      


Leu Pro Asp Leu Pro Pro Pro Lys Met Ile Pro Glu Arg Lys Gln Leu 
            100                 105                 110         


Ala Ile Pro Lys Thr Glu Ser Pro Glu Gly Tyr Tyr Glu Glu Ala Glu 
        115                 120                 125             


Pro Tyr Asp Thr Ser Leu Asn Glu Asp Gly Glu Ala Val Ser Ser Ser 
    130                 135                 140                 


Tyr Glu Ser Tyr Asp Glu Glu Asp Gly Ser Lys Gly Lys Ser Ala Pro 
145                 150                 155                 160 


Tyr Gln Trp Pro Ser Pro Glu Ala Gly Ile Glu Leu Met Arg Asp Ala 
                165                 170                 175     


Arg Ile Cys Ala Phe Leu Trp Arg Lys Lys Trp Leu Gly Gln Trp Ala 
            180                 185                 190         


Lys Gln Leu Cys Val Ile Lys Asp Asn Arg Leu Leu Cys Tyr Lys Ser 
        195                 200                 205             


Ser Lys Asp His Ser Pro Gln Leu Asp Val Asn Leu Leu Gly Ser Ser 
    210                 215                 220                 


Val Ile His Lys Glu Lys Gln Val Arg Lys Lys Glu His Lys Leu Lys 
225                 230                 235                 240 


Ile Thr Pro Met Asn Ala Asp Val Ile Val Leu Gly Leu Gln Ser Lys 
                245                 250                 255     


Asp Gln Ala Glu Gln Trp Leu Arg Val Ile Gln Glu Val Ser Gly Leu 
            260                 265                 270         


Pro Ser Glu Gly Ala Ser Glu Gly Asn Gln Tyr Thr Pro Asp Ala Gln 
        275                 280                 285             


Arg Phe Asn Cys Gln Lys Pro Asp Ile Ala Glu Lys Tyr Leu Ser Ala 
    290                 295                 300                 


Ser Glu Tyr Gly Ser Ser Val Asp Gly His Pro Glu Val Pro Glu Thr 
305                 310                 315                 320 


Lys Asp Val Lys Lys Lys Cys Ser Ala Gly Leu Lys Leu Ser Asn Leu 
                325                 330                 335     


Met Asn Leu Gly Arg Lys Lys Ser Thr Ser Leu Glu Pro Val Glu Arg 
            340                 345                 350         


Ser Leu Glu Thr Ser Ser Tyr Leu Asn Val Leu Val Asn Ser Gln Trp 
        355                 360                 365             


Lys Ser Arg Trp Cys Ser Val Arg Asp Asn His Leu His Phe Tyr Gln 
    370                 375                 380                 


Asp Arg Asn Arg Ser Lys Val Ala Gln Gln Pro Leu Ser Leu Val Gly 
385                 390                 395                 400 


Cys Glu Val Val Pro Asp Pro Ser Pro Asp His Leu Tyr Ser Phe Arg 
                405                 410                 415     


Ile Leu His Lys Gly Glu Glu Leu Ala Lys Leu Glu Ala Lys Ser Ser 
            420                 425                 430         


Glu Glu Met Gly His Trp Leu Gly Leu Leu Leu Ser Glu Ser Gly Ser 
        435                 440                 445             


Lys Thr Asp Pro Glu Glu Phe Thr Tyr Asp Tyr Val Asp Ala Asp Arg 
    450                 455                 460                 


Val Ser Cys Ile Val Ser Ala Ala Lys Asn Ser Leu Leu Leu Met Gln 
465                 470                 475                 480 


Arg Lys Phe Ser Glu Pro Asn Thr Tyr Ile Asp Gly Leu Pro Ser Gln 
                485                 490                 495     


Asp Arg Gln Glu Glu Leu Tyr Asp Asp Val Asp Leu Ser Glu Leu Thr 
            500                 505                 510         


Ala Ala Val Glu Pro Thr Glu Glu Ala Thr Pro Val Ala Asp Asp Pro 
        515                 520                 525             


Asn Glu Arg Glu Ser Asp Arg Val Tyr Leu Asp Leu Thr Pro Val Lys 
    530                 535                 540                 


Ser Phe Leu His Gly Pro Ser Ser Ala Gln Ala Gln Ala Ser Ser Pro 
545                 550                 555                 560 


Thr Leu Ser Cys Leu Asp Asn Ala Thr Glu Ala Leu Pro Ala Asp Ser 
                565                 570                 575     


Gly Pro Gly Pro Thr Pro Asp Glu Pro Cys Ile Lys Cys Pro Glu Asn 
            580                 585                 590         


Leu Gly Glu Gln Gln Leu Glu Ser Leu Glu Pro Glu Asp Pro Ser Leu 
        595                 600                 605             


Arg Ile Thr Thr Val Lys Ile Gln Thr Glu Gln Gln Arg Ile Ser Phe 
    610                 615                 620                 


Pro Pro Ser Cys Pro Asp Ala Val Val Ala Thr Pro Pro Gly Ala Ser 
625                 630                 635                 640 


Pro Pro Val Lys Asp Arg Leu Arg Val Thr Ser Ala Glu Ile Lys Leu 
                645                 650                 655     


Gly Lys Asn Arg Thr Glu Ala Glu Val Lys Arg Tyr Thr Glu Glu Lys 
            660                 665                 670         


Glu Arg Leu Glu Lys Lys Lys Glu Glu Ile Arg Gly His Leu Ala Gln 
        675                 680                 685             


Leu Arg Lys Glu Lys Arg Glu Leu Lys Glu Thr Leu Leu Lys Cys Thr 
    690                 695                 700                 


Asp Lys Glu Val Leu Ala Ser Leu Glu Gln Lys Leu Lys Glu Ile Asp 
705                 710                 715                 720 


Glu Glu Cys Arg Gly Glu Glu Ser Arg Arg Val Asp Leu Glu Leu Ser 
                725                 730                 735     


Ile Met Glu Val Lys Asp Asn Leu Lys Lys Ala Glu Ala Gly Pro Val 
            740                 745                 750         


Thr Leu Gly Thr Thr Val Asp Thr Thr His Leu Glu Asn Val Ser Pro 
        755                 760                 765             


Arg Pro Lys Ala Val Thr Pro Ala Ser Ala Pro Asp Cys Thr Pro Val 
    770                 775                 780                 


Asn Ser Ala Thr Thr Leu Lys Asn Arg Pro Leu Ser Val Val Val Thr 
785                 790                 795                 800 


Gly Lys Gly Thr Val Leu Gln Lys Ala Lys Glu Trp Glu Lys Lys Gly 
                805                 810                 815     


Ala Ser 
        


<210>  17
<211>  1606
<212>  DNA
<213>  Homo sapiens

<400>  17
aaatgtgacc ggccgcggct ccggcagtca acgcctgcct cctctcgagc gtcctcagcg       60

cagccgccgc ccgcggagcc agcacgaacg agcccagcac cggccggatg gagcgtccgc      120

aacccgacag catgccccag gatttgtcag aggccctgaa ggaggccacc aaggaggtgc      180

acacccaggc agagaatgct gagttcatga ggaactttca gaagggccag gtgacccgag      240

acggcttcaa gctggtgatg gcctccctgt accacatcta tgtggccctg gaggaggaga      300

ttgagcgcaa caaggagagc ccagtcttcg cccctgtcta cttcccagaa gagctgcacc      360

gcaaggctgc cctggagcag gacctggcct tctggtacgg gccccgctgg caggaggtca      420

tcccctacac accagccatg cagcgctatg tgaagcggct ccacgaggtg gggcgcacag      480

agcccgagct gctggtggcc cacgcctaca cccgctacct gggtgacctg tctgggggcc      540

aggtgctcaa aaagattgcc cagaaagccc tggacctgcc cagctctggc gagggcctgg      600

ccttcttcac cttccccaac attgccagtg ccaccaagtt caagcagctc taccgctccc      660

gcatgaactc cctggagatg actcccgcag tcaggcagag ggtgatagaa gaggccaaga      720

ctgcgttcct gctcaacatc cagctctttg aggagttgca ggagctgctg acccatgaca      780

ccaaggacca gagcccctca cgggcaccag ggcttcgcca gcgggccagc aacaaagtgc      840

aagattctgc ccccgtggag actcccagag ggaagccccc actcaacacc cgctcccagg      900

ctccgcttct ccgatgggtc cttacactca gctttctggt ggcgacagtt gctgtagggc      960

tttatgccat gtgaatgcag gcatgctggc tcccagggcc atgaactttg tccggtggaa     1020

ggccttcttt ctagagaggg aattctcttg gctggcttcc ttaccgtggg cactgaaggc     1080

tttcagggcc tccagccctc tcactgtgtc cctctctctg gaaaggagga aggagcctat     1140

ggcatcttcc ccaacgaaaa gcacatccag gcaatggcct aaacttcaga gggggcgaag     1200

ggatcagccc tgcccttcag catcctcagt tcctgcagca gagcctggaa gacaccctaa     1260

tgtggcagct gtctcaaacc tccaaaagcc ctgagtttca agtatccttg ttgacacggc     1320

catgaccact ttccccgtgg gccatggcaa tttttacaca aacctgaaaa gatgttgtgt     1380

cttgtgtttt tgtcttattt ttgttggagc cactctgttc ctggctcagc ctcaaatgca     1440

gtatttttgt tgtgttctgt tgtttttata gcagggttgg ggtggttttt gagccatgcg     1500

tgggtgggga gggaggtgtt taacggcact gtggccttgg tctaactttt gtgtgaaata     1560

ataaacaaca ttgtctgata gtagcttgaa aaaaaaaaaa aaaaaa                    1606


<210>  18
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser Glu Ala 
1               5                   10                  15      


Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly Phe Lys 
        35                  40                  45              


Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu Glu Glu 
    50                  55                  60                  


Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr Phe Pro 
65                  70                  75                  80  


Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala Phe Trp 
                85                  90                  95      


Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala Met Gln 
            100                 105                 110         


Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro Glu Leu 
        115                 120                 125             


Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser Gly Gly 
    130                 135                 140                 


Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro Ser Ser 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser Ala Thr 
                165                 170                 175     


Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu Met Thr 
            180                 185                 190         


Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala Phe Leu 
        195                 200                 205             


Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr His Asp 
    210                 215                 220                 


Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg Gln Arg Ala 
225                 230                 235                 240 


Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro Arg Gly Lys 
                245                 250                 255     


Pro Pro Leu Asn Thr Arg Ser Gln Ala Pro Leu Leu Arg Trp Val Leu 
            260                 265                 270         


Thr Leu Ser Phe Leu Val Ala Thr Val Ala Val Gly Leu Tyr Ala Met 
        275                 280                 285             


<210>  19
<211>  2207
<212>  DNA
<213>  Homo sapiens

<400>  19
cacttcctcc ccagacaggg gtagtgcgag gccgggcaca gccttcctgt gtggttttac       60

cgcccagaga gcgtcatgga cctggggaaa ccaatgaaaa gcgtgctggt ggtggctctc      120

cttgtcattt tccaggtatg cctgtgtcaa gatgaggtca cggacgatta catcggagac      180

aacaccacag tggactacac tttgttcgag tctttgtgct ccaagaagga cgtgcggaac      240

tttaaagcct ggttcctccc tatcatgtac tccatcattt gtttcgtggg cctactgggc      300

aatgggctgg tcgtgttgac ctatatctat ttcaagaggc tcaagaccat gaccgatacc      360

tacctgctca acctggcggt ggcagacatc ctcttcctcc tgacccttcc cttctgggcc      420

tacagcgcgg ccaagtcctg ggtcttcggt gtccactttt gcaagctcat ctttgccatc      480

tacaagatga gcttcttcag tggcatgctc ctacttcttt gcatcagcat tgaccgctac      540

gtggccatcg tccaggctgt ctcagctcac cgccaccgtg cccgcgtcct tctcatcagc      600

aagctgtcct gtgtgggcat ctggatacta gccacagtgc tctccatccc agagctcctg      660

tacagtgacc tccagaggag cagcagtgag caagcgatgc gatgctctct catcacagag      720

catgtggagg cctttatcac catccaggtg gcccagatgg tgatcggctt tctggtcccc      780

ctgctggcca tgagcttctg ttaccttgtc atcatccgca ccctgctcca ggcacgcaac      840

tttgagcgca acaaggccat caaggtgatc atcgctgtgg tcgtggtctt catagtcttc      900

cagctgccct acaatggggt ggtcctggcc cagacggtgg ccaacttcaa catcaccagt      960

agcacctgtg agctcagtaa gcaactcaac atcgcctacg acgtcaccta cagcctggcc     1020

tgcgtccgct gctgcgtcaa ccctttcttg tacgccttca tcggcgtcaa gttccgcaac     1080

gatctcttca agctcttcaa ggacctgggc tgcctcagcc aggagcagct ccggcagtgg     1140

tcttcctgtc ggcacatccg gcgctcctcc atgagtgtgg aggccgagac caccaccacc     1200

ttctccccat aggcgactct tctgcctgga ctagagggac ctctcccagg gtccctgggg     1260

tggggatagg gagcagatgc aatgactcag gacatccccc cgccaaaagc tgctcaggga     1320

aaagcagctc tcccctcaga gtgcaagccc ctgctccaga agatagcttc accccaatcc     1380

cagctacctc aaccaatgcc aaaaaaagac agggctgata agctaacacc agacagacaa     1440

cactgggaaa cagaggctat tgtcccctaa accaaaaact gaaagtgaaa gtccagaaac     1500

tgttcccacc tgctggagtg aaggggccaa ggagggtgag tgcaaggggc gtgggagtgg     1560

cctgaagagt cctctgaatg aaccttctgg cctcccacag actcaaatgc tcagaccagc     1620

tcttccgaaa accaggcctt atctccaaga ccagagatag tggggagact tcttggcttg     1680

gtgaggaaaa gcggacatca gctggtcaaa caaactctct gaacccctcc ctccatcgtt     1740

ttcttcactg tcctccaagc cagcgggaat ggcagctgcc acgccgccct aaaagcacac     1800

tcatcccctc acttgccgcg tcgccctccc aggctctcaa caggggagag tgtggtgttt     1860

cctgcaggcc aggccagctg cctccgcgtg atcaaagcca cactctgggc tccagagtgg     1920

ggatgacatg cactcagctc ttggctccac tgggatggga ggagaggaca agggaaatgt     1980

caggggcggg gagggtgaca gtggccgccc aaggcccacg agcttgttct ttgttctttg     2040

tcacagggac tgaaaacctc tcctcatgtt ctgctttcga ttcgttaaga gagcaacatt     2100

ttacccacac acagataaag ttttcccttg aggaaacaac agctttaaaa gaaaaagaaa     2160

aaaaaagtct ttggtaaatg gcaaaaaaaa aaaaaaaaaa aaaaaaa                   2207


<210>  20
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


