                               SEQUENCE LISTING

<110> BILET, MAXIME J.J.
      FUSHMAN, ILYA
      HYDE, RODERICK A.
      KARE, JORDIN T.
      KHOSLA, VINOD
      MANN, DAVID
      MYHRVOLD, NATHAN P.
      TEGREENE, CLARENCE T.
      WOOD, LOWELL L., Jr.
      YOUNG, CHRISTOPHER C.
 
<120> EDIBLE OR INHALABLE COMPOSITIONS HAVING ANTIBODIES AND METHODS
      OF USE

<130> 04113802PCT1

<150> US 13/686,741
<151> 27/11/2013

<160> 34    

<170> PatentIn version 3.5

<210> 1
<211> 841
<212> PRT
<213> Homo sapiens

<400> 1
Met Leu Leu Cys Thr Ala Arg Leu Val Gly Leu Gln Leu Leu Ile Ser 
1               5                   10                  15      


Cys Cys Trp Ala Phe Ala Cys His Ser Thr Glu Ser Ser Pro Asp Phe 
            20                  25                  30          


Thr Leu Pro Gly Asp Tyr Leu Leu Ala Gly Leu Phe Pro Leu His Ser 
        35                  40                  45              


Gly Cys Leu Gln Val Arg His Arg Pro Glu Val Thr Leu Cys Asp Arg 
    50                  55                  60                  


Ser Cys Ser Phe Asn Glu His Gly Tyr His Leu Phe Gln Ala Met Arg 
65                  70                  75                  80  


Leu Gly Val Glu Glu Ile Asn Asn Ser Thr Ala Leu Leu Pro Asn Ile 
                85                  90                  95      


Thr Leu Gly Tyr Gln Leu Tyr Asp Val Cys Ser Asp Ser Ala Asn Val 
            100                 105                 110         


Tyr Ala Thr Leu Arg Val Leu Ser Leu Pro Gly Gln His His Ile Glu 
        115                 120                 125             


Leu Gln Gly Asp Leu Leu His Tyr Ser Pro Thr Val Leu Ala Val Ile 
    130                 135                 140                 


Gly Pro Asp Ser Thr Asn Arg Ala Ala Thr Thr Ala Ala Leu Leu Ser 
145                 150                 155                 160 


Pro Phe Leu Val Pro Met Ile Ser Tyr Ala Ala Ser Ser Glu Thr Leu 
                165                 170                 175     


Ser Val Lys Arg Gln Tyr Pro Ser Phe Leu Arg Thr Ile Pro Asn Asp 
            180                 185                 190         


Lys Tyr Gln Val Glu Thr Met Val Leu Leu Leu Gln Lys Phe Gly Trp 
        195                 200                 205             


Thr Trp Ile Ser Leu Val Gly Ser Ser Asp Asp Tyr Gly Gln Leu Gly 
    210                 215                 220                 


Val Gln Ala Leu Glu Asn Gln Ala Thr Gly Gln Gly Ile Cys Ile Ala 
225                 230                 235                 240 


Phe Lys Asp Ile Met Pro Phe Ser Ala Gln Val Gly Asp Glu Arg Met 
                245                 250                 255     


Gln Cys Leu Met Arg His Leu Ala Gln Ala Gly Ala Thr Val Val Val 
            260                 265                 270         


Val Phe Ser Ser Arg Gln Leu Ala Arg Val Phe Phe Glu Ser Val Val 
        275                 280                 285             


Leu Thr Asn Leu Thr Gly Lys Val Trp Val Ala Ser Glu Ala Trp Ala 
    290                 295                 300                 


Leu Ser Arg His Ile Thr Gly Val Pro Gly Ile Gln Arg Ile Gly Met 
305                 310                 315                 320 


Val Leu Gly Val Ala Ile Gln Lys Arg Ala Val Pro Gly Leu Lys Ala 
                325                 330                 335     


Phe Glu Glu Ala Tyr Ala Arg Ala Asp Lys Glu Ala Pro Arg Pro Cys 
            340                 345                 350         


His Lys Gly Ser Trp Cys Ser Ser Asn Gln Leu Cys Arg Glu Cys Gln 
        355                 360                 365             


Ala Phe Met Ala His Thr Met Pro Lys Leu Lys Ala Phe Ser Met Ser 
    370                 375                 380                 


Ser Ala Tyr Asn Ala Tyr Arg Ala Val Tyr Ala Val Ala His Gly Leu 
385                 390                 395                 400 


His Gln Leu Leu Gly Cys Ala Ser Gly Ala Cys Ser Arg Gly Arg Val 
                405                 410                 415     


Tyr Pro Trp Gln Leu Leu Glu Gln Ile His Lys Val His Phe Leu Leu 
            420                 425                 430         


His Lys Asp Thr Val Ala Phe Asn Asp Asn Arg Asp Pro Leu Ser Ser 
        435                 440                 445             


Tyr Asn Ile Ile Ala Trp Asp Trp Asn Gly Pro Lys Trp Thr Phe Thr 
    450                 455                 460                 


Val Leu Gly Ser Ser Thr Trp Ser Pro Val Gln Leu Asn Ile Asn Glu 
465                 470                 475                 480 


Thr Lys Ile Gln Trp His Gly Lys Asp Asn Gln Val Pro Lys Ser Val 
                485                 490                 495     


Cys Ser Ser Asp Cys Leu Glu Gly His Gln Arg Val Val Thr Gly Phe 
            500                 505                 510         


His His Cys Cys Phe Glu Cys Val Pro Cys Gly Ala Gly Thr Phe Leu 
        515                 520                 525             


Asn Lys Ser Asp Leu Tyr Arg Cys Gln Pro Cys Gly Lys Glu Glu Trp 
    530                 535                 540                 


Ala Pro Glu Gly Ser Gln Thr Cys Phe Pro Arg Thr Val Val Phe Leu 
545                 550                 555                 560 


Ala Leu Arg Glu His Thr Ser Trp Val Leu Leu Ala Ala Asn Thr Leu 
                565                 570                 575     


Leu Leu Leu Leu Leu Leu Gly Thr Ala Gly Leu Phe Ala Trp His Leu 
            580                 585                 590         


Asp Thr Pro Val Val Arg Ser Ala Gly Gly Arg Leu Cys Phe Leu Met 
        595                 600                 605             


Leu Gly Ser Leu Ala Ala Gly Ser Gly Ser Leu Tyr Gly Phe Phe Gly 
    610                 615                 620                 


Glu Pro Thr Arg Pro Ala Cys Leu Leu Arg Gln Ala Leu Phe Ala Leu 
625                 630                 635                 640 


Gly Phe Thr Ile Phe Leu Ser Cys Leu Thr Val Arg Ser Phe Gln Leu 
                645                 650                 655     


Ile Ile Ile Phe Lys Phe Ser Thr Lys Val Pro Thr Phe Tyr His Ala 
            660                 665                 670         


Trp Val Gln Asn His Gly Ala Gly Leu Phe Val Met Ile Ser Ser Ala 
        675                 680                 685             


Ala Gln Leu Leu Ile Cys Leu Thr Trp Leu Val Val Trp Thr Pro Leu 
    690                 695                 700                 


Pro Ala Arg Glu Tyr Gln Arg Phe Pro His Leu Val Met Leu Glu Cys 
705                 710                 715                 720 


Thr Glu Thr Asn Ser Leu Gly Phe Ile Leu Ala Phe Leu Tyr Asn Gly 
                725                 730                 735     


Leu Leu Ser Ile Ser Ala Phe Ala Cys Ser Tyr Leu Gly Lys Asp Leu 
            740                 745                 750         


Pro Glu Asn Tyr Asn Glu Ala Lys Cys Val Thr Phe Ser Leu Leu Phe 
        755                 760                 765             


Asn Phe Val Ser Trp Ile Ala Phe Phe Thr Thr Ala Ser Val Tyr Asp 
    770                 775                 780                 


Gly Lys Tyr Leu Pro Ala Ala Asn Met Met Ala Gly Leu Ser Ser Leu 
785                 790                 795                 800 


Ser Ser Gly Phe Gly Gly Tyr Phe Leu Pro Lys Cys Tyr Val Ile Leu 
                805                 810                 815     


Cys Arg Pro Asp Leu Asn Ser Thr Glu His Phe Gln Ala Ser Ile Gln 
            820                 825                 830         


Asp Tyr Thr Arg Arg Cys Gly Ser Thr 
        835                 840     


<210> 2
<211> 839
<212> PRT
<213> Homo sapiens

<400> 2
Met Gly Pro Arg Ala Lys Thr Ile Ser Ser Leu Phe Phe Leu Leu Trp 
1               5                   10                  15      


Val Leu Ala Glu Pro Ala Glu Asn Ser Asp Phe Tyr Leu Pro Gly Asp 
            20                  25                  30          


Tyr Leu Leu Gly Gly Leu Phe Ser Leu His Ala Asn Met Lys Gly Ile 
        35                  40                  45              


Val His Leu Asn Phe Leu Gln Val Pro Met Cys Lys Glu Tyr Glu Val 
    50                  55                  60                  


Lys Val Ile Gly Tyr Asn Leu Met Gln Ala Met Arg Phe Ala Val Glu 
65                  70                  75                  80  


Glu Ile Asn Asn Asp Ser Ser Leu Leu Pro Gly Val Leu Leu Gly Tyr 
                85                  90                  95      


Glu Ile Val Asp Val Cys Tyr Ile Ser Asn Asn Val Gln Pro Val Leu 
            100                 105                 110         


Tyr Phe Leu Ala His Glu Asp Asn Leu Leu Pro Ile Gln Glu Asp Tyr 
        115                 120                 125             


Ser Asn Tyr Ile Ser Arg Val Val Ala Val Ile Gly Pro Asp Asn Ser 
    130                 135                 140                 


Glu Ser Val Met Thr Val Ala Asn Phe Leu Ser Leu Phe Leu Leu Pro 
145                 150                 155                 160 


Gln Ile Thr Tyr Ser Ala Ile Ser Asp Glu Leu Arg Asp Lys Val Arg 
                165                 170                 175     


Phe Pro Ala Leu Leu Arg Thr Thr Pro Ser Ala Asp His His Ile Glu 
            180                 185                 190         


Ala Met Val Gln Leu Met Leu His Phe Arg Trp Asn Trp Ile Ile Val 
        195                 200                 205             


Leu Val Ser Ser Asp Thr Tyr Gly Arg Asp Asn Gly Gln Leu Leu Gly 
    210                 215                 220                 


Glu Arg Val Ala Arg Arg Asp Ile Cys Ile Ala Phe Gln Glu Thr Leu 
225                 230                 235                 240 


Pro Thr Leu Gln Pro Asn Gln Asn Met Thr Ser Glu Glu Arg Gln Arg 
                245                 250                 255     


Leu Val Thr Ile Val Asp Lys Leu Gln Gln Ser Thr Ala Arg Val Val 
            260                 265                 270         


Val Val Phe Ser Pro Asp Leu Thr Leu Tyr His Phe Phe Asn Glu Val 
        275                 280                 285             


Leu Arg Gln Asn Phe Thr Gly Ala Val Trp Ile Ala Ser Glu Ser Trp 
    290                 295                 300                 


Ala Ile Asp Pro Val Leu His Asn Leu Thr Glu Leu Arg His Leu Gly 
305                 310                 315                 320 


Thr Phe Leu Gly Ile Thr Ile Gln Ser Val Pro Ile Pro Gly Phe Ser 
                325                 330                 335     


Glu Phe Arg Glu Trp Gly Pro Gln Ala Gly Pro Pro Pro Leu Ser Arg 
            340                 345                 350         


Thr Ser Gln Ser Tyr Thr Cys Asn Gln Glu Cys Asp Asn Cys Leu Asn 
        355                 360                 365             


Ala Thr Leu Ser Phe Asn Thr Ile Leu Arg Leu Ser Gly Glu Arg Val 
    370                 375                 380                 


Val Tyr Ser Val Tyr Ser Ala Val Tyr Ala Val Ala His Ala Leu His 
385                 390                 395                 400 


Ser Leu Leu Gly Cys Asp Lys Ser Thr Cys Thr Lys Arg Val Val Tyr 
                405                 410                 415     


Pro Trp Gln Leu Leu Glu Glu Ile Trp Lys Val Asn Phe Thr Leu Leu 
            420                 425                 430         


Asp His Gln Ile Phe Phe Asp Pro Gln Gly Asp Val Ala Leu His Leu 
        435                 440                 445             


Glu Ile Val Gln Trp Gln Trp Asp Arg Ser Gln Asn Pro Phe Gln Ser 
    450                 455                 460                 


Val Ala Ser Tyr Tyr Pro Leu Gln Arg Gln Leu Lys Asn Ile Gln Asp 
465                 470                 475                 480 


Ile Ser Trp His Thr Ile Asn Asn Thr Ile Pro Met Ser Met Cys Ser 
                485                 490                 495     


Lys Arg Cys Gln Ser Gly Gln Lys Lys Lys Pro Val Gly Ile His Val 
            500                 505                 510         


Cys Cys Phe Glu Cys Ile Asp Cys Leu Pro Gly Thr Phe Leu Asn His 
        515                 520                 525             


Thr Glu Asp Glu Tyr Glu Cys Gln Ala Cys Pro Asn Asn Glu Trp Ser 
    530                 535                 540                 


Tyr Gln Ser Glu Thr Ser Cys Phe Lys Arg Gln Leu Val Phe Leu Glu 
545                 550                 555                 560 


Trp His Glu Ala Pro Thr Ile Ala Val Ala Leu Leu Ala Ala Leu Gly 
                565                 570                 575     


Phe Leu Ser Thr Leu Ala Ile Leu Val Ile Phe Trp Arg His Phe Gln 
            580                 585                 590         


Thr Pro Ile Val Arg Ser Ala Gly Gly Pro Met Cys Phe Leu Met Leu 
        595                 600                 605             


Thr Leu Leu Leu Val Ala Tyr Met Val Val Pro Val Tyr Val Gly Pro 
    610                 615                 620                 


Pro Lys Val Ser Thr Cys Leu Cys Arg Gln Ala Leu Phe Pro Leu Cys 
625                 630                 635                 640 


Phe Thr Ile Cys Ile Ser Cys Ile Ala Val Arg Ser Phe Gln Ile Val 
                645                 650                 655     


Cys Ala Phe Lys Met Ala Ser Arg Phe Pro Arg Ala Tyr Ser Tyr Trp 
            660                 665                 670         


Val Arg Tyr Gln Gly Pro Tyr Val Ser Met Ala Phe Ile Thr Val Leu 
        675                 680                 685             


Lys Met Val Ile Val Val Ile Gly Met Leu Ala Thr Gly Leu Ser Pro 
    690                 695                 700                 


Thr Thr Arg Thr Asp Pro Asp Asp Pro Lys Ile Thr Ile Val Ser Cys 
705                 710                 715                 720 


Asn Pro Asn Tyr Arg Asn Ser Leu Leu Phe Asn Thr Ser Leu Asp Leu 
                725                 730                 735     


Leu Leu Ser Val Val Gly Phe Ser Phe Ala Tyr Met Gly Lys Glu Leu 
            740                 745                 750         


Pro Thr Asn Tyr Asn Glu Ala Lys Phe Ile Thr Leu Ser Met Thr Phe 
        755                 760                 765             


Tyr Phe Thr Ser Ser Val Ser Leu Cys Thr Phe Met Ser Ala Tyr Ser 
    770                 775                 780                 


Gly Val Leu Val Thr Ile Val Asp Leu Leu Val Thr Val Leu Asn Leu 
785                 790                 795                 800 


Leu Ala Ile Ser Leu Gly Tyr Phe Gly Pro Lys Cys Tyr Met Ile Leu 
                805                 810                 815     


Phe Tyr Pro Glu Arg Asn Thr Pro Ala Tyr Phe Asn Ser Met Ile Gln 
            820                 825                 830         


Gly Tyr Thr Met Arg Arg Asp 
        835                 


<210> 3
<211> 852
<212> PRT
<213> Homo sapiens

<400> 3
Met Leu Gly Pro Ala Val Leu Gly Leu Ser Leu Trp Ala Leu Leu His 
1               5                   10                  15      


Pro Gly Thr Gly Ala Pro Leu Cys Leu Ser Gln Gln Leu Arg Met Lys 
            20                  25                  30          


Gly Asp Tyr Val Leu Gly Gly Leu Phe Pro Leu Gly Glu Ala Glu Glu 
        35                  40                  45              


Ala Gly Leu Arg Ser Arg Thr Arg Pro Ser Ser Pro Val Cys Thr Arg 
    50                  55                  60                  


Phe Ser Ser Asn Gly Leu Leu Trp Ala Leu Ala Met Lys Met Ala Val 
65                  70                  75                  80  


Glu Glu Ile Asn Asn Lys Ser Asp Leu Leu Pro Gly Leu Arg Leu Gly 
                85                  90                  95      


Tyr Asp Leu Phe Asp Thr Cys Ser Glu Pro Val Val Ala Met Lys Pro 
            100                 105                 110         


Ser Leu Met Phe Leu Ala Lys Ala Gly Ser Arg Asp Ile Ala Ala Tyr 
        115                 120                 125             


Cys Asn Tyr Thr Gln Tyr Gln Pro Arg Val Leu Ala Val Ile Gly Pro 
    130                 135                 140                 


His Ser Ser Glu Leu Ala Met Val Thr Gly Lys Phe Phe Ser Phe Phe 
145                 150                 155                 160 


Leu Met Pro Gln Val Ser Tyr Gly Ala Ser Met Glu Leu Leu Ser Ala 
                165                 170                 175     


Arg Glu Thr Phe Pro Ser Phe Phe Arg Thr Val Pro Ser Asp Arg Val 
            180                 185                 190         


Gln Leu Thr Ala Ala Ala Glu Leu Leu Gln Glu Phe Gly Trp Asn Trp 
        195                 200                 205             


Val Ala Ala Leu Gly Ser Asp Asp Glu Tyr Gly Arg Gln Gly Leu Ser 
    210                 215                 220                 


Ile Phe Ser Ala Leu Ala Ala Ala Arg Gly Ile Cys Ile Ala His Glu 
225                 230                 235                 240 


Gly Leu Val Pro Leu Pro Arg Ala Asp Asp Ser Arg Leu Gly Lys Val 
                245                 250                 255     


Gln Asp Val Leu His Gln Val Asn Gln Ser Ser Val Gln Val Val Leu 
            260                 265                 270         


Leu Phe Ala Ser Val His Ala Ala His Ala Leu Phe Asn Tyr Ser Ile 
        275                 280                 285             


Ser Ser Arg Leu Ser Pro Lys Val Trp Val Ala Ser Glu Ala Trp Leu 
    290                 295                 300                 


Thr Ser Asp Leu Val Met Gly Leu Pro Gly Met Ala Gln Met Gly Thr 
305                 310                 315                 320 


Val Leu Gly Phe Leu Gln Arg Gly Ala Gln Leu His Glu Phe Pro Gln 
                325                 330                 335     


Tyr Val Lys Thr His Leu Ala Leu Ala Thr Asp Pro Ala Phe Cys Ser 
            340                 345                 350         


Ala Leu Gly Glu Arg Glu Gln Gly Leu Glu Glu Asp Val Val Gly Gln 
        355                 360                 365             


Arg Cys Pro Gln Cys Asp Cys Ile Thr Leu Gln Asn Val Ser Ala Gly 
    370                 375                 380                 


Leu Asn His His Gln Thr Phe Ser Val Tyr Ala Ala Val Tyr Ser Val 
385                 390                 395                 400 


Ala Gln Ala Leu His Asn Thr Leu Gln Cys Asn Ala Ser Gly Cys Pro 
                405                 410                 415     


Ala Gln Asp Pro Val Lys Pro Trp Gln Leu Leu Glu Asn Met Tyr Asn 
            420                 425                 430         


Leu Thr Phe His Val Gly Gly Leu Pro Leu Arg Phe Asp Ser Ser Gly 
        435                 440                 445             


Asn Val Asp Met Glu Tyr Asp Leu Lys Leu Trp Val Trp Gln Gly Ser 
    450                 455                 460                 


Val Pro Arg Leu His Asp Val Gly Arg Phe Asn Gly Ser Leu Arg Thr 
465                 470                 475                 480 


Glu Arg Leu Lys Ile Arg Trp His Thr Ser Asp Asn Gln Lys Pro Val 
                485                 490                 495     


Ser Arg Cys Ser Arg Gln Cys Gln Glu Gly Gln Val Arg Arg Val Lys 
            500                 505                 510         


Gly Phe His Ser Cys Cys Tyr Asp Cys Val Asp Cys Glu Ala Gly Ser 
        515                 520                 525             


Tyr Arg Gln Asn Pro Asp Asp Ile Ala Cys Thr Phe Cys Gly Gln Asp 
    530                 535                 540                 


Glu Trp Ser Pro Glu Arg Ser Thr Arg Cys Phe Arg Arg Arg Ser Arg 
545                 550                 555                 560 


Phe Leu Ala Trp Gly Glu Pro Ala Val Leu Leu Leu Leu Leu Leu Leu 
                565                 570                 575     


Ser Leu Ala Leu Gly Leu Val Leu Ala Ala Leu Gly Leu Phe Val His 
            580                 585                 590         


His Arg Asp Ser Pro Leu Val Gln Ala Ser Gly Gly Pro Leu Ala Cys 
        595                 600                 605             


Phe Gly Leu Val Cys Leu Gly Leu Val Cys Leu Ser Val Leu Leu Phe 
    610                 615                 620                 


Pro Gly Gln Pro Ser Pro Ala Arg Cys Leu Ala Gln Gln Pro Leu Ser 
625                 630                 635                 640 


His Leu Pro Leu Thr Gly Cys Leu Ser Thr Leu Phe Leu Gln Ala Ala 
                645                 650                 655     


Glu Ile Phe Val Glu Ser Glu Leu Pro Leu Ser Trp Ala Asp Arg Leu 
            660                 665                 670         


Ser Gly Cys Leu Arg Gly Pro Trp Ala Trp Leu Val Val Leu Leu Ala 
        675                 680                 685             


Met Leu Val Glu Val Ala Leu Cys Thr Trp Tyr Leu Val Ala Phe Pro 
    690                 695                 700                 


Pro Glu Val Val Thr Asp Trp His Met Leu Pro Thr Glu Ala Leu Val 
705                 710                 715                 720 


His Cys Arg Thr Arg Ser Trp Val Ser Phe Gly Leu Ala His Ala Thr 
                725                 730                 735     


Asn Ala Thr Leu Ala Phe Leu Cys Phe Leu Gly Thr Phe Leu Val Arg 
            740                 745                 750         


Ser Gln Pro Gly Arg Tyr Asn Arg Ala Arg Gly Leu Thr Phe Ala Met 
        755                 760                 765             


Leu Ala Tyr Phe Ile Thr Trp Val Ser Phe Val Pro Leu Leu Ala Asn 
    770                 775                 780                 


Val Gln Val Val Leu Arg Pro Ala Val Gln Met Gly Ala Leu Leu Leu 
785                 790                 795                 800 


Cys Val Leu Gly Ile Leu Ala Ala Phe His Leu Pro Arg Cys Tyr Leu 
                805                 810                 815     


Leu Met Arg Gln Pro Gly Leu Asn Thr Pro Glu Phe Phe Leu Gly Gly 
            820                 825                 830         


Gly Pro Gly Asp Ala Gln Gly Gln Asn Asp Gly Asn Thr Gly Asn Gln 
        835                 840                 845             


Gly Lys His Glu 
    850         


<210> 4
<211> 299
<212> PRT
<213> Homo sapiens

<400> 4
Met Leu Glu Ser His Leu Ile Ile Tyr Phe Leu Leu Ala Val Ile Gln 
1               5                   10                  15      


Phe Leu Leu Gly Ile Phe Thr Asn Gly Ile Ile Val Val Val Asn Gly 
            20                  25                  30          


Ile Asp Leu Ile Lys His Arg Lys Met Ala Pro Leu Asp Leu Leu Leu 
        35                  40                  45              


Ser Cys Leu Ala Val Ser Arg Ile Phe Leu Gln Leu Phe Ile Phe Tyr 
    50                  55                  60                  


Val Asn Val Ile Val Ile Phe Phe Ile Glu Phe Ile Met Cys Ser Ala 
65                  70                  75                  80  


Asn Cys Ala Ile Leu Leu Phe Ile Asn Glu Leu Glu Leu Trp Leu Ala 
                85                  90                  95      


Thr Trp Leu Gly Val Phe Tyr Cys Ala Lys Val Ala Ser Val Arg His 
            100                 105                 110         


Pro Leu Phe Ile Trp Leu Lys Met Arg Ile Ser Lys Leu Val Pro Trp 
        115                 120                 125             


Met Ile Leu Gly Ser Leu Leu Tyr Val Ser Met Ile Cys Val Phe His 
    130                 135                 140                 


Ser Lys Tyr Ala Gly Phe Met Val Pro Tyr Phe Leu Arg Lys Phe Phe 
145                 150                 155                 160 


Ser Gln Asn Ala Thr Ile Gln Lys Glu Asp Thr Leu Ala Ile Gln Ile 
                165                 170                 175     


Phe Ser Phe Val Ala Glu Phe Ser Val Pro Leu Leu Ile Phe Leu Phe 
            180                 185                 190         


Ala Val Leu Leu Leu Ile Phe Ser Leu Gly Arg His Thr Arg Gln Met 
        195                 200                 205             


Arg Asn Thr Val Ala Gly Ser Arg Val Pro Gly Arg Gly Ala Pro Ile 
    210                 215                 220                 


Ser Ala Leu Leu Ser Ile Leu Ser Phe Leu Ile Leu Tyr Phe Ser His 
225                 230                 235                 240 


Cys Met Ile Lys Val Phe Leu Ser Ser Leu Lys Phe His Ile Arg Arg 
                245                 250                 255     


Phe Ile Phe Leu Phe Phe Ile Leu Val Ile Gly Ile Tyr Pro Ser Gly 
            260                 265                 270         


His Ser Leu Ile Leu Ile Leu Gly Asn Pro Lys Leu Lys Gln Asn Ala 
        275                 280                 285             


Lys Lys Phe Leu Leu His Ser Lys Cys Cys Gln 
    290                 295                 


<210> 5
<211> 316
<212> PRT
<213> Homo sapiens

<400> 5
Met Met Gly Leu Thr Glu Gly Val Phe Leu Ile Leu Ser Gly Thr Gln 
1               5                   10                  15      


Phe Thr Leu Gly Ile Leu Val Asn Cys Phe Ile Glu Leu Val Asn Gly 
            20                  25                  30          


Ser Ser Trp Phe Lys Thr Lys Arg Met Ser Leu Ser Asp Phe Ile Ile 
        35                  40                  45              


Thr Thr Leu Ala Leu Leu Arg Ile Ile Leu Leu Cys Ile Ile Leu Thr 
    50                  55                  60                  


Asp Ser Phe Leu Ile Glu Phe Ser Pro Asn Thr His Asp Ser Gly Ile 
65                  70                  75                  80  


Ile Met Gln Ile Ile Asp Val Ser Trp Thr Phe Thr Asn His Leu Ser 
                85                  90                  95      


Ile Trp Leu Ala Thr Cys Leu Gly Val Leu Tyr Cys Leu Lys Ile Ala 
            100                 105                 110         


Ser Phe Ser His Pro Thr Phe Leu Trp Leu Lys Trp Arg Val Ser Arg 
        115                 120                 125             


Val Met Val Trp Met Leu Leu Gly Ala Leu Leu Leu Ser Cys Gly Ser 
    130                 135                 140                 


Thr Ala Ser Leu Ile Asn Glu Phe Lys Leu Tyr Ser Val Phe Arg Gly 
145                 150                 155                 160 


Ile Glu Ala Thr Arg Asn Val Thr Glu His Phe Arg Lys Lys Arg Ser 
                165                 170                 175     


Glu Tyr Tyr Leu Ile His Val Leu Gly Thr Leu Trp Tyr Leu Pro Pro 
            180                 185                 190         


Leu Ile Val Ser Leu Ala Ser Tyr Ser Leu Leu Ile Phe Ser Leu Gly 
        195                 200                 205             


Arg His Thr Arg Gln Met Leu Gln Asn Gly Thr Ser Ser Arg Asp Pro 
    210                 215                 220                 


Thr Thr Glu Ala His Lys Arg Ala Ile Arg Ile Ile Leu Ser Phe Phe 
225                 230                 235                 240 


Phe Leu Phe Leu Leu Tyr Phe Leu Ala Phe Leu Ile Ala Ser Phe Gly 
                245                 250                 255     


Asn Phe Leu Pro Lys Thr Lys Met Ala Lys Met Ile Gly Glu Val Met 
            260                 265                 270         


Thr Met Phe Tyr Pro Ala Gly His Ser Phe Ile Leu Ile Leu Gly Asn 
        275                 280                 285             


Ser Lys Leu Lys Gln Thr Phe Val Val Met Leu Arg Cys Glu Ser Gly 
    290                 295                 300                 


His Leu Lys Pro Gly Ser Lys Gly Pro Ile Phe Ser 
305                 310                 315     


<210> 6
<211> 299
<212> PRT
<213> Homo sapiens

<400> 6
Met Leu Arg Leu Phe Tyr Phe Ser Ala Ile Ile Ala Ser Val Ile Leu 
1               5                   10                  15      


Asn Phe Val Gly Ile Ile Met Asn Leu Phe Ile Thr Val Val Asn Cys 
            20                  25                  30          


Lys Thr Trp Val Lys Ser His Arg Ile Ser Ser Ser Asp Arg Ile Leu 
        35                  40                  45              


Phe Ser Leu Gly Ile Thr Arg Phe Leu Met Leu Gly Leu Phe Leu Val 
    50                  55                  60                  


Asn Thr Ile Tyr Phe Val Ser Ser Asn Thr Glu Arg Ser Val Tyr Leu 
65                  70                  75                  80  


Ser Ala Phe Phe Val Leu Cys Phe Met Phe Leu Asp Ser Ser Ser Val 
                85                  90                  95      


Trp Phe Val Thr Leu Leu Asn Ile Leu Tyr Cys Val Lys Ile Thr Asn 
            100                 105                 110         


Phe Gln His Ser Val Phe Leu Leu Leu Lys Arg Asn Ile Ser Pro Lys 
        115                 120                 125             


Ile Pro Arg Leu Leu Leu Ala Cys Val Leu Ile Ser Ala Phe Thr Thr 
    130                 135                 140                 


Cys Leu Tyr Ile Thr Leu Ser Gln Ala Ser Pro Phe Pro Glu Leu Val 
145                 150                 155                 160 


Thr Thr Arg Asn Asn Thr Ser Phe Asn Ile Ser Glu Gly Ile Leu Ser 
                165                 170                 175     


Leu Val Val Ser Leu Val Leu Ser Ser Ser Leu Gln Phe Ile Ile Asn 
            180                 185                 190         


Val Thr Ser Ala Ser Leu Leu Ile His Ser Leu Arg Arg His Ile Gln 
        195                 200                 205             


Lys Met Gln Lys Asn Ala Thr Gly Phe Trp Asn Pro Gln Thr Glu Ala 
    210                 215                 220                 


His Val Gly Ala Met Lys Leu Met Val Tyr Phe Leu Ile Leu Tyr Ile 
225                 230                 235                 240 


Pro Tyr Ser Val Ala Thr Leu Val Gln Tyr Leu Pro Phe Tyr Ala Gly 
                245                 250                 255     


Met Asp Met Gly Thr Lys Ser Ile Cys Leu Ile Phe Ala Thr Leu Tyr 
            260                 265                 270         


Ser Pro Gly His Ser Val Leu Ile Ile Ile Thr His Pro Lys Leu Lys 
        275                 280                 285             


Thr Thr Ala Lys Lys Ile Leu Cys Phe Lys Lys 
    290                 295                 


<210> 7
<211> 299
<212> PRT
<213> Homo sapiens

<400> 7
Met Leu Ser Ala Gly Leu Gly Leu Leu Met Leu Val Ala Val Val Glu 
1               5                   10                  15      


Phe Leu Ile Gly Leu Ile Gly Asn Gly Ser Leu Val Val Trp Ser Phe 
            20                  25                  30          


Arg Glu Trp Ile Arg Lys Phe Asn Trp Ser Ser Tyr Asn Leu Ile Ile 
        35                  40                  45              


Leu Gly Leu Ala Gly Cys Arg Phe Leu Leu Gln Trp Leu Ile Ile Leu 
    50                  55                  60                  


Asp Leu Ser Leu Phe Pro Leu Phe Gln Ser Ser Arg Trp Leu Arg Tyr 
65                  70                  75                  80  


Leu Ser Ile Phe Trp Val Leu Val Ser Gln Ala Ser Leu Trp Phe Ala 
                85                  90                  95      


Thr Phe Leu Ser Val Phe Tyr Cys Lys Lys Ile Thr Thr Phe Asp Arg 
            100                 105                 110         


Pro Ala Tyr Leu Trp Leu Lys Gln Arg Ala Tyr Asn Leu Ser Leu Trp 
        115                 120                 125             


Cys Leu Leu Gly Tyr Phe Ile Ile Asn Leu Leu Leu Thr Val Gln Ile 
    130                 135                 140                 


Gly Leu Thr Phe Tyr His Pro Pro Gln Gly Asn Ser Ser Ile Arg Tyr 
145                 150                 155                 160 


Pro Phe Glu Ser Trp Gln Tyr Leu Tyr Ala Phe Gln Leu Asn Ser Gly 
                165                 170                 175     


Ser Tyr Leu Pro Leu Val Val Phe Leu Val Ser Ser Gly Met Leu Ile 
            180                 185                 190         


Val Ser Leu Tyr Thr His His Lys Lys Met Lys Val His Ser Ala Gly 
        195                 200                 205             


Arg Arg Asp Val Arg Ala Lys Ala His Ile Thr Ala Leu Lys Ser Leu 
    210                 215                 220                 


Gly Cys Phe Leu Leu Leu His Leu Val Tyr Ile Met Ala Ser Pro Phe 
225                 230                 235                 240 


Ser Ile Thr Ser Lys Thr Tyr Pro Pro Asp Leu Thr Ser Val Phe Ile 
                245                 250                 255     


Trp Glu Thr Leu Met Ala Ala Tyr Pro Ser Leu His Ser Leu Ile Leu 
            260                 265                 270         


Ile Met Gly Ile Pro Arg Val Lys Gln Thr Cys Gln Lys Ile Leu Trp 
        275                 280                 285             


Lys Thr Val Cys Ala Arg Arg Cys Trp Gly Pro 
    290                 295                 


<210> 8
<211> 318
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala Asp Lys Val Gln Thr Thr Leu Leu Phe Leu Ala Val Gly Glu 
1               5                   10                  15      


Phe Ser Val Gly Ile Leu Gly Asn Ala Phe Ile Gly Leu Val Asn Cys 
            20                  25                  30          


Met Asp Trp Val Lys Lys Arg Lys Ile Ala Ser Ile Asp Leu Ile Leu 
        35                  40                  45              


Thr Ser Leu Ala Ile Ser Arg Ile Cys Leu Leu Cys Val Ile Leu Leu 
    50                  55                  60                  


Asp Cys Phe Ile Leu Val Leu Tyr Pro Asp Val Tyr Ala Thr Gly Lys 
65                  70                  75                  80  


Glu Met Arg Ile Ile Asp Phe Phe Trp Thr Leu Thr Asn His Leu Ser 
                85                  90                  95      


Ile Trp Phe Ala Thr Cys Leu Ser Ile Tyr Tyr Phe Phe Lys Ile Gly 
            100                 105                 110         


Asn Phe Phe His Pro Leu Phe Leu Trp Met Lys Trp Arg Ile Asp Arg 
        115                 120                 125             


Val Ile Ser Trp Ile Leu Leu Gly Cys Val Val Leu Ser Val Phe Ile 
    130                 135                 140                 


Ser Leu Pro Ala Thr Glu Asn Leu Asn Ala Asp Phe Arg Phe Cys Val 
145                 150                 155                 160 


Lys Ala Lys Arg Lys Thr Asn Leu Thr Trp Ser Cys Arg Val Asn Lys 
                165                 170                 175     


Thr Gln His Ala Ser Thr Lys Leu Phe Leu Asn Leu Ala Thr Leu Leu 
            180                 185                 190         


Pro Phe Cys Val Cys Leu Met Ser Phe Phe Leu Leu Ile Leu Ser Leu 
        195                 200                 205             


Arg Arg His Ile Arg Arg Met Gln Leu Ser Ala Thr Gly Cys Arg Asp 
    210                 215                 220                 


Pro Ser Thr Glu Ala His Val Arg Ala Leu Lys Ala Val Ile Ser Phe 
225                 230                 235                 240 


Leu Leu Leu Phe Ile Ala Tyr Tyr Leu Ser Phe Leu Ile Ala Thr Ser 
                245                 250                 255     


Ser Tyr Phe Met Pro Glu Thr Glu Leu Ala Val Ile Phe Gly Glu Ser 
            260                 265                 270         


Ile Ala Leu Ile Tyr Pro Ser Ser His Ser Phe Ile Leu Ile Leu Gly 
        275                 280                 285             


Asn Asn Lys Leu Arg His Ala Ser Leu Lys Val Ile Trp Lys Val Met 
    290                 295                 300                 


Ser Ile Leu Lys Gly Arg Lys Phe Gln Gln His Lys Gln Ile 
305                 310                 315             


<210> 9
<211> 309
<212> PRT
<213> Homo sapiens

<400> 9
Met Phe Ser Pro Ala Asp Asn Ile Phe Ile Ile Leu Ile Thr Gly Glu 
1               5                   10                  15      


Phe Ile Leu Gly Ile Leu Gly Asn Gly Tyr Ile Ala Leu Val Asn Trp 
            20                  25                  30          


Ile Asp Trp Ile Lys Lys Lys Lys Ile Ser Thr Val Asp Tyr Ile Leu 
        35                  40                  45              


Thr Asn Leu Val Ile Ala Arg Ile Cys Leu Ile Ser Val Met Val Val 
    50                  55                  60                  


Asn Gly Ile Val Ile Val Leu Asn Pro Asp Val Tyr Thr Lys Asn Lys 
65                  70                  75                  80  


Gln Gln Ile Val Ile Phe Thr Phe Trp Thr Phe Ala Asn Tyr Leu Asn 
                85                  90                  95      


Met Trp Ile Thr Thr Cys Leu Asn Val Phe Tyr Phe Leu Lys Ile Ala 
            100                 105                 110         


Ser Ser Ser His Pro Leu Phe Leu Trp Leu Lys Trp Lys Ile Asp Met 
        115                 120                 125             


Val Val His Trp Ile Leu Leu Gly Cys Phe Ala Ile Ser Leu Leu Val 
    130                 135                 140                 


Ser Leu Ile Ala Ala Ile Val Leu Ser Cys Asp Tyr Arg Phe His Ala 
145                 150                 155                 160 


Ile Ala Lys His Lys Arg Asn Ile Thr Glu Met Phe His Val Ser Lys 
                165                 170                 175     


Ile Pro Tyr Phe Glu Pro Leu Thr Leu Phe Asn Leu Phe Ala Ile Val 
            180                 185                 190         


Pro Phe Ile Val Ser Leu Ile Ser Phe Phe Leu Leu Val Arg Ser Leu 
        195                 200                 205             


Trp Arg His Thr Lys Gln Ile Lys Leu Tyr Ala Thr Gly Ser Arg Asp 
    210                 215                 220                 


Pro Ser Thr Glu Val His Val Arg Ala Ile Lys Thr Met Thr Ser Phe 
225                 230                 235                 240 


Ile Phe Phe Phe Phe Leu Tyr Tyr Ile Ser Ser Ile Leu Met Thr Phe 
                245                 250                 255     


Ser Tyr Leu Met Thr Lys Tyr Lys Leu Ala Val Glu Phe Gly Glu Ile 
            260                 265                 270         


Ala Ala Ile Leu Tyr Pro Leu Gly His Ser Leu Ile Leu Ile Val Leu 
        275                 280                 285             


Asn Asn Lys Leu Arg Gln Thr Phe Val Arg Met Leu Thr Cys Arg Lys 
    290                 295                 300                 


Ile Ala Cys Val Ile 
305                 


<210> 10
<211> 312
<212> PRT
<213> Homo sapiens

<400> 10
Met Pro Ser Ala Ile Glu Ala Ile Tyr Ile Ile Leu Ile Ala Gly Glu 
1               5                   10                  15      


Leu Thr Ile Gly Ile Trp Gly Asn Gly Phe Ile Val Leu Val Asn Cys 
            20                  25                  30          


Ile Asp Trp Leu Lys Arg Arg Asp Ile Ser Leu Ile Asp Ile Ile Leu 
        35                  40                  45              


Ile Ser Leu Ala Ile Ser Arg Ile Cys Leu Leu Cys Val Ile Ser Leu 
    50                  55                  60                  


Asp Gly Phe Phe Met Leu Leu Phe Pro Gly Thr Tyr Gly Asn Ser Val 
65                  70                  75                  80  


Leu Val Ser Ile Val Asn Val Val Trp Thr Phe Ala Asn Asn Ser Ser 
                85                  90                  95      


Leu Trp Phe Thr Ser Cys Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala 
            100                 105                 110         


Asn Ile Ser His Pro Phe Phe Phe Trp Leu Lys Leu Lys Ile Asn Lys 
        115                 120                 125             


Val Met Leu Ala Ile Leu Leu Gly Ser Phe Leu Ile Ser Leu Ile Ile 
    130                 135                 140                 


Ser Val Pro Lys Asn Asp Asp Met Trp Tyr His Leu Phe Lys Val Ser 
145                 150                 155                 160 


His Glu Glu Asn Ile Thr Trp Lys Phe Lys Val Ser Lys Ile Pro Gly 
                165                 170                 175     


Thr Phe Lys Gln Leu Thr Leu Asn Leu Gly Ala Met Val Pro Phe Ile 
            180                 185                 190         


Leu Cys Leu Ile Ser Phe Phe Leu Leu Leu Phe Ser Leu Val Arg His 
        195                 200                 205             


Thr Lys Gln Ile Arg Leu His Ala Thr Gly Phe Arg Asp Pro Ser Thr 
    210                 215                 220                 


Glu Ala His Met Arg Ala Ile Lys Ala Val Ile Ile Phe Leu Leu Leu 
225                 230                 235                 240 


Leu Ile Val Tyr Tyr Pro Val Phe Leu Val Met Thr Ser Ser Ala Leu 
                245                 250                 255     


Ile Pro Gln Gly Lys Leu Val Leu Met Ile Gly Asp Ile Val Thr Val 
            260                 265                 270         


Ile Phe Pro Ser Ser His Ser Phe Ile Leu Ile Met Gly Asn Ser Lys 
        275                 280                 285             


Leu Arg Glu Ala Phe Leu Lys Met Leu Arg Phe Val Lys Cys Phe Leu 
    290                 295                 300                 


Arg Arg Arg Lys Pro Phe Val Pro 
305                 310         


<210> 11
<211> 307
<212> PRT
<213> Homo sapiens

<400> 11
Met Leu Arg Val Val Glu Gly Ile Phe Ile Phe Val Val Val Ser Glu 
1               5                   10                  15      


Ser Val Phe Gly Val Leu Gly Asn Gly Phe Ile Gly Leu Val Asn Cys 
            20                  25                  30          


Ile Asp Cys Ala Lys Asn Lys Leu Ser Thr Ile Gly Phe Ile Leu Thr 
        35                  40                  45              


Gly Leu Ala Ile Ser Arg Ile Phe Leu Ile Trp Ile Ile Ile Thr Asp 
    50                  55                  60                  


Gly Phe Ile Gln Ile Phe Ser Pro Asn Ile Tyr Ala Ser Gly Asn Leu 
65                  70                  75                  80  


Ile Glu Tyr Ile Ser Tyr Phe Trp Val Ile Gly Asn Gln Ser Ser Met 
                85                  90                  95      


Trp Phe Ala Thr Ser Leu Ser Ile Phe Tyr Phe Leu Lys Ile Ala Asn 
            100                 105                 110         


Phe Ser Asn Tyr Ile Phe Leu Trp Leu Lys Ser Arg Thr Asn Met Val 
        115                 120                 125             


Leu Pro Phe Met Ile Val Phe Leu Leu Ile Ser Ser Leu Leu Asn Phe 
    130                 135                 140                 


Ala Tyr Ile Ala Lys Ile Leu Asn Asp Tyr Lys Met Lys Asn Asp Thr 
145                 150                 155                 160 


Val Trp Asp Leu Asn Met Tyr Lys Ser Glu Tyr Phe Ile Lys Gln Ile 
                165                 170                 175     


Leu Leu Asn Leu Gly Val Ile Phe Phe Phe Thr Leu Ser Leu Ile Thr 
            180                 185                 190         


Cys Ile Phe Leu Ile Ile Ser Leu Trp Arg His Asn Arg Gln Met Gln 
        195                 200                 205             


Ser Asn Val Thr Gly Leu Arg Asp Ser Asn Thr Glu Ala His Val Lys 
    210                 215                 220                 


Ala Met Lys Val Leu Ile Ser Phe Ile Ile Leu Phe Ile Leu Tyr Phe 
225                 230                 235                 240 


Ile Gly Met Ala Ile Glu Ile Ser Cys Phe Thr Val Arg Glu Asn Lys 
                245                 250                 255     


Leu Leu Leu Met Phe Gly Met Thr Thr Thr Ala Ile Tyr Pro Trp Gly 
            260                 265                 270         


His Ser Phe Ile Leu Ile Leu Gly Asn Ser Lys Leu Lys Gln Ala Ser 
        275                 280                 285             


Leu Arg Val Leu Gln Gln Leu Lys Cys Cys Glu Lys Arg Lys Asn Leu 
    290                 295                 300                 


Arg Val Thr 
305         


<210> 12
<211> 300
<212> PRT
<213> Homo sapiens

<400> 12
Met Glu Ser Ala Leu Pro Ser Ile Phe Thr Leu Val Ile Ile Ala Glu 
1               5                   10                  15      


Phe Ile Ile Gly Asn Leu Ser Asn Gly Phe Ile Val Leu Ile Asn Cys 
            20                  25                  30          


Ile Asp Trp Val Ser Lys Arg Glu Leu Ser Ser Val Asp Lys Leu Leu 
        35                  40                  45              


Ile Ile Leu Ala Ile Ser Arg Ile Gly Leu Ile Trp Glu Ile Leu Val 
    50                  55                  60                  


Ser Trp Phe Leu Ala Leu His Tyr Leu Ala Ile Phe Val Ser Gly Thr 
65                  70                  75                  80  


Gly Leu Arg Ile Met Ile Phe Ser Trp Ile Val Ser Asn His Phe Asn 
                85                  90                  95      


Leu Trp Leu Ala Thr Ile Phe Ser Ile Phe Tyr Leu Leu Lys Ile Ala 
            100                 105                 110         


Ser Phe Ser Ser Pro Ala Phe Leu Tyr Leu Lys Trp Arg Val Asn Lys 
        115                 120                 125             


Val Ile Leu Met Ile Leu Leu Gly Thr Leu Val Phe Leu Phe Leu Asn 
    130                 135                 140                 


Leu Ile Gln Ile Asn Met His Ile Lys Asp Trp Leu Asp Arg Tyr Glu 
145                 150                 155                 160 


Arg Asn Thr Thr Trp Asn Phe Ser Met Ser Asp Phe Glu Thr Phe Ser 
                165                 170                 175     


Val Ser Val Lys Phe Thr Met Thr Met Phe Ser Leu Thr Pro Phe Thr 
            180                 185                 190         


Val Ala Phe Ile Ser Phe Leu Leu Leu Ile Phe Ser Leu Gln Lys His 
        195                 200                 205             


Leu Gln Lys Met Gln Leu Asn Tyr Lys Gly His Arg Asp Pro Arg Thr 
    210                 215                 220                 


Lys Val His Thr Asn Ala Leu Lys Ile Val Ile Ser Phe Leu Leu Phe 
225                 230                 235                 240 


Tyr Ala Ser Phe Phe Leu Cys Val Leu Ile Ser Trp Ile Ser Glu Leu 
                245                 250                 255     


Tyr Gln Ser Thr Val Ile Tyr Met Leu Cys Glu Thr Ile Gly Val Phe 
            260                 265                 270         


Ser Pro Ser Ser His Ser Phe Leu Leu Ile Leu Gly Asn Ala Lys Leu 
        275                 280                 285             


Arg Gln Ala Phe Leu Leu Val Ala Ala Lys Val Trp 
    290                 295                 300 


<210> 13
<211> 317
<212> PRT
<213> Homo sapiens

<400> 13
Met Gly Gly Val Ile Lys Ser Ile Phe Thr Phe Val Leu Ile Val Glu 
1               5                   10                  15      


Phe Ile Ile Gly Asn Leu Gly Asn Ser Phe Ile Ala Leu Val Asn Cys 
            20                  25                  30          


Ile Asp Trp Val Lys Gly Arg Lys Ile Ser Ser Val Asp Arg Ile Leu 
        35                  40                  45              


Thr Ala Leu Ala Ile Ser Arg Ile Ser Leu Val Trp Leu Ile Phe Gly 
    50                  55                  60                  


Ser Trp Cys Val Ser Val Phe Phe Pro Ala Leu Phe Ala Thr Glu Lys 
65                  70                  75                  80  


Met Phe Arg Met Leu Thr Asn Ile Trp Thr Val Ile Asn His Phe Ser 
                85                  90                  95      


Val Trp Leu Ala Thr Gly Leu Gly Thr Phe Tyr Phe Leu Lys Ile Ala 
            100                 105                 110         


Asn Phe Ser Asn Ser Ile Phe Leu Tyr Leu Lys Trp Arg Val Lys Lys 
        115                 120                 125             


Val Val Leu Val Leu Leu Leu Val Thr Ser Val Phe Leu Phe Leu Asn 
    130                 135                 140                 


Ile Ala Leu Ile Asn Ile His Ile Asn Ala Ser Ile Asn Gly Tyr Arg 
145                 150                 155                 160 


Arg Asn Lys Thr Cys Ser Ser Asp Ser Ser Asn Phe Thr Arg Phe Ser 
                165                 170                 175     


Ser Leu Ile Val Leu Thr Ser Thr Val Phe Ile Phe Ile Pro Phe Thr 
            180                 185                 190         


Leu Ser Leu Ala Met Phe Leu Leu Leu Ile Phe Ser Met Trp Lys His 
        195                 200                 205             


Arg Lys Lys Met Gln His Thr Val Lys Ile Ser Gly Asp Ala Ser Thr 
    210                 215                 220                 


Lys Ala His Arg Gly Val Lys Ser Val Ile Thr Phe Phe Leu Leu Tyr 
225                 230                 235                 240 


Ala Ile Phe Ser Leu Ser Phe Phe Ile Ser Val Trp Thr Ser Glu Arg 
                245                 250                 255     


Leu Glu Glu Asn Leu Ile Ile Leu Ser Gln Val Met Gly Met Ala Tyr 
            260                 265                 270         


Pro Ser Cys His Ser Cys Val Leu Ile Leu Gly Asn Lys Lys Leu Arg 
        275                 280                 285             


Gln Ala Ser Leu Ser Val Leu Leu Trp Leu Arg Tyr Met Phe Lys Asp 
    290                 295                 300                 


Gly Glu Pro Ser Gly His Lys Glu Phe Arg Glu Ser Ser 
305                 310                 315         


<210> 14
<211> 291
<212> PRT
<213> Homo sapiens

<400> 14
Met Ile Pro Ile Gln Leu Thr Val Phe Phe Met Ile Ile Tyr Val Leu 
1               5                   10                  15      


Glu Ser Leu Thr Ile Ile Val Gln Ser Ser Leu Ile Val Ala Val Leu 
            20                  25                  30          


Gly Arg Glu Trp Leu Gln Val Arg Arg Leu Met Pro Val Asp Met Ile 
        35                  40                  45              


Leu Ile Ser Leu Gly Ile Ser Arg Phe Cys Leu Gln Trp Ala Ser Met 
    50                  55                  60                  


Leu Asn Asn Phe Cys Ser Tyr Phe Asn Leu Asn Tyr Val Leu Cys Asn 
65                  70                  75                  80  


Leu Thr Ile Thr Trp Glu Phe Phe Asn Ile Leu Thr Phe Trp Leu Asn 
                85                  90                  95      


Ser Leu Leu Thr Val Phe Tyr Cys Ile Lys Val Ser Ser Phe Thr His 
            100                 105                 110         


His Ile Phe Leu Trp Leu Arg Trp Arg Ile Leu Arg Leu Phe Pro Trp 
        115                 120                 125             


Ile Leu Leu Gly Ser Leu Met Ile Thr Cys Val Thr Ile Ile Pro Ser 
    130                 135                 140                 


Ala Ile Gly Asn Tyr Ile Gln Ile Gln Leu Leu Thr Met Glu His Leu 
145                 150                 155                 160 


Pro Arg Asn Ser Thr Val Thr Asp Lys Leu Glu Asn Phe His Gln Tyr 
                165                 170                 175     


Gln Phe Gln Ala His Thr Val Ala Leu Val Ile Pro Phe Ile Leu Phe 
            180                 185                 190         


Leu Ala Ser Thr Ile Phe Leu Met Ala Ser Leu Thr Lys Gln Ile Gln 
        195                 200                 205             


His His Ser Thr Gly His Cys Asn Pro Ser Met Lys Ala Arg Phe Thr 
    210                 215                 220                 


Ala Leu Arg Ser Leu Ala Val Leu Phe Ile Val Phe Thr Ser Tyr Phe 
225                 230                 235                 240 


Leu Thr Ile Leu Ile Thr Ile Ile Gly Thr Leu Phe Asp Lys Arg Cys 
                245                 250                 255     


Trp Leu Trp Val Trp Glu Ala Phe Val Tyr Ala Phe Ile Leu Met His 
            260                 265                 270         


Ser Thr Ser Leu Met Leu Ser Ser Pro Thr Leu Lys Arg Ile Leu Lys 
        275                 280                 285             


Gly Lys Cys 
    290     


<210> 15
<211> 299
<212> PRT
<213> Homo sapiens

<400> 15
Met Met Cys Phe Leu Leu Ile Ile Ser Ser Ile Leu Val Val Phe Ala 
1               5                   10                  15      


Phe Val Leu Gly Asn Val Ala Asn Gly Phe Ile Ala Leu Val Asn Val 
            20                  25                  30          


Ile Asp Trp Val Asn Thr Arg Lys Ile Ser Ser Ala Glu Gln Ile Leu 
        35                  40                  45              


Thr Ala Leu Val Val Ser Arg Ile Gly Leu Leu Trp Val Met Leu Phe 
    50                  55                  60                  


Leu Trp Tyr Ala Thr Val Phe Asn Ser Ala Leu Tyr Gly Leu Glu Val 
65                  70                  75                  80  


Arg Ile Val Ala Ser Asn Ala Trp Ala Val Thr Asn His Phe Ser Met 
                85                  90                  95      


Trp Leu Ala Ala Ser Leu Ser Ile Phe Cys Leu Leu Lys Ile Ala Asn 
            100                 105                 110         


Phe Ser Asn Leu Ile Ser Leu His Leu Lys Lys Arg Ile Lys Ser Val 
        115                 120                 125             


Val Leu Val Ile Leu Leu Gly Pro Leu Val Phe Leu Ile Cys Asn Leu 
    130                 135                 140                 


Ala Val Ile Thr Met Asp Glu Arg Val Trp Thr Lys Glu Tyr Glu Gly 
145                 150                 155                 160 


Asn Val Thr Trp Lys Ile Lys Leu Arg Asn Ala Ile His Leu Ser Ser 
                165                 170                 175     


Leu Thr Val Thr Thr Leu Ala Asn Leu Ile Pro Phe Thr Leu Ser Leu 
            180                 185                 190         


Ile Cys Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys 
        195                 200                 205             


Met Arg Leu His Ser Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His 
    210                 215                 220                 


Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Met Leu Phe Ala Ile 
225                 230                 235                 240 


Tyr Phe Leu Cys Ile Ile Thr Ser Thr Trp Asn Leu Arg Thr Gln Gln 
                245                 250                 255     


Ser Lys Leu Val Leu Leu Leu Cys Gln Thr Val Ala Ile Met Tyr Pro 
            260                 265                 270         


Ser Phe His Ser Phe Ile Leu Ile Met Gly Ser Arg Lys Leu Lys Gln 
        275                 280                 285             


Thr Phe Leu Ser Val Leu Trp Gln Met Thr Arg 
    290                 295                 


<210> 16
<211> 309
<212> PRT
<213> Homo sapiens

<400> 16
Met Met Ser Phe Leu His Ile Val Phe Ser Ile Leu Val Val Val Ala 
1               5                   10                  15      


Phe Ile Leu Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Ile Asn Phe 
            20                  25                  30          


Ile Ala Trp Val Lys Arg Gln Lys Ile Ser Ser Ala Asp Gln Ile Ile 
        35                  40                  45              


Ala Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Ile Leu Leu 
    50                  55                  60                  


His Trp Tyr Ser Thr Val Leu Asn Pro Thr Ser Ser Asn Leu Lys Val 
65                  70                  75                  80  


Ile Ile Phe Ile Ser Asn Ala Trp Ala Val Thr Asn His Phe Ser Ile 
                85                  90                  95      


Trp Leu Ala Thr Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Val Asn 
            100                 105                 110         


Phe Ser Arg Leu Ile Phe His His Leu Lys Arg Lys Ala Lys Ser Val 
        115                 120                 125             


Val Leu Val Ile Val Leu Gly Ser Leu Phe Phe Leu Val Cys His Leu 
    130                 135                 140                 


Val Met Lys His Thr Tyr Ile Asn Val Trp Thr Glu Glu Cys Glu Gly 
145                 150                 155                 160 


Asn Val Thr Trp Lys Ile Lys Leu Arg Asn Ala Met His Leu Ser Asn 
                165                 170                 175     


Leu Thr Val Ala Met Leu Ala Asn Leu Ile Pro Phe Thr Leu Thr Leu 
            180                 185                 190         


Ile Ser Phe Leu Leu Leu Ile Tyr Ser Leu Cys Lys His Leu Lys Lys 
        195                 200                 205             


Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Ile His 
    210                 215                 220                 


Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Ile Leu Leu Ala Ile 
225                 230                 235                 240 


Tyr Phe Leu Cys Leu Ile Ile Ser Phe Trp Asn Phe Lys Met Arg Pro 
                245                 250                 255     


Lys Glu Ile Val Leu Met Leu Cys Gln Ala Phe Gly Ile Ile Tyr Pro 
            260                 265                 270         


Ser Phe His Ser Phe Ile Leu Ile Trp Gly Asn Lys Thr Leu Lys Gln 
        275                 280                 285             


Thr Phe Leu Ser Val Leu Trp Gln Val Thr Cys Trp Ala Lys Gly Gln 
    290                 295                 300                 


Asn Gln Ser Thr Pro 
305                 


<210> 17
<211> 319
<212> PRT
<213> Homo sapiens

<400> 17
Met Ile Thr Phe Leu Pro Ile Ile Phe Ser Ile Leu Ile Val Val Ile 
1               5                   10                  15      


Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser 
            20                  25                  30          


Ile Glu Trp Val Lys Arg Gln Lys Ile Ser Phe Val Asp Gln Ile Leu 
        35                  40                  45              


Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Leu Leu 
    50                  55                  60                  


His Trp Tyr Ala Thr Gln Leu Asn Pro Ala Phe Tyr Ser Val Glu Val 
65                  70                  75                  80  


Arg Ile Thr Ala Tyr Asn Val Trp Ala Val Thr Asn His Phe Ser Ser 
                85                  90                  95      


Trp Leu Ala Thr Ser Leu Ser Met Phe Tyr Leu Leu Arg Ile Ala Asn 
            100                 105                 110         


Phe Ser Asn Leu Ile Phe Leu Arg Ile Lys Arg Arg Val Lys Ser Val 
        115                 120                 125             


Val Leu Val Ile Leu Leu Gly Pro Leu Leu Phe Leu Val Cys His Leu 
    130                 135                 140                 


Phe Val Ile Asn Met Asp Glu Thr Val Trp Thr Lys Glu Tyr Glu Gly 
145                 150                 155                 160 


Asn Val Thr Trp Lys Ile Lys Leu Arg Ser Ala Met Tyr His Ser Asn 
                165                 170                 175     


Met Thr Leu Thr Met Leu Ala Asn Phe Val Pro Leu Thr Leu Thr Leu 
            180                 185                 190         


Ile Ser Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys 
        195                 200                 205             


Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His 
    210                 215                 220                 


Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Leu Leu Cys Ala Ile 
225                 230                 235                 240 


Tyr Phe Leu Ser Met Ile Ile Ser Val Cys Asn Phe Gly Arg Leu Glu 
                245                 250                 255     


Lys Gln Pro Val Phe Met Phe Cys Gln Ala Ile Ile Phe Ser Tyr Pro 
            260                 265                 270         


Ser Thr His Pro Phe Ile Leu Ile Leu Gly Asn Lys Lys Leu Lys Gln 
        275                 280                 285             


Ile Phe Leu Ser Val Leu Arg His Val Arg Tyr Trp Val Lys Asp Arg 
    290                 295                 300                 


Ser Leu Arg Leu His Arg Phe Thr Arg Gly Ala Leu Cys Val Phe 
305                 310                 315                 


<210> 18
<211> 309
<212> PRT
<213> Homo sapiens

<400> 18
Met Thr Thr Phe Ile Pro Ile Ile Phe Ser Ser Val Val Val Val Leu 
1               5                   10                  15      


Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser 
            20                  25                  30          


Ile Glu Arg Val Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Leu 
        35                  40                  45              


Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Leu Leu 
    50                  55                  60                  


Asn Trp Tyr Ser Thr Val Phe Asn Pro Ala Phe Tyr Ser Val Glu Val 
65                  70                  75                  80  


Arg Thr Thr Ala Tyr Asn Val Trp Ala Val Thr Gly His Phe Ser Asn 
                85                  90                  95      


Trp Leu Ala Thr Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn 
            100                 105                 110         


Phe Ser Asn Leu Ile Phe Leu His Leu Lys Arg Arg Val Lys Ser Val 
        115                 120                 125             


Ile Leu Val Met Leu Leu Gly Pro Leu Leu Phe Leu Ala Cys Gln Leu 
    130                 135                 140                 


Phe Val Ile Asn Met Lys Glu Ile Val Arg Thr Lys Glu Tyr Glu Gly 
145                 150                 155                 160 


Asn Leu Thr Trp Lys Ile Lys Leu Arg Ser Ala Val Tyr Leu Ser Asp 
                165                 170                 175     


Ala Thr Val Thr Thr Leu Gly Asn Leu Val Pro Phe Thr Leu Thr Leu 
            180                 185                 190         


Leu Cys Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys 
        195                 200                 205             


Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His 
    210                 215                 220                 


Ile Lys Ala Leu Gln Thr Val Ile Phe Phe Leu Leu Leu Cys Ala Val 
225                 230                 235                 240 


Tyr Phe Leu Ser Ile Met Ile Ser Val Trp Ser Phe Gly Ser Leu Glu 
                245                 250                 255     


Asn Lys Pro Val Phe Met Phe Cys Lys Ala Ile Arg Phe Ser Tyr Pro 
            260                 265                 270         


Ser Ile His Pro Phe Ile Leu Ile Trp Gly Asn Lys Lys Leu Lys Gln 
        275                 280                 285             


Thr Phe Leu Ser Val Leu Arg Gln Val Arg Tyr Trp Val Lys Gly Glu 
    290                 295                 300                 


Lys Pro Ser Ser Pro 
305                 


<210> 19
<211> 333
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (49)..(49)
<223> Any amino acid

<400> 19
Met Leu Thr Leu Thr Arg Ile Arg Thr Val Ser Tyr Glu Val Arg Ser 
1               5                   10                  15      


Thr Phe Leu Phe Ile Ser Val Leu Glu Phe Ala Val Gly Phe Leu Thr 
            20                  25                  30          


Asn Ala Phe Val Phe Leu Val Asn Phe Trp Asp Val Val Lys Arg Gln 
        35                  40                  45              


Xaa Leu Ser Asn Ser Asp Cys Val Leu Leu Cys Leu Ser Ile Ser Arg 
    50                  55                  60                  


Leu Phe Leu His Gly Leu Leu Phe Leu Ser Ala Ile Gln Leu Thr His 
65                  70                  75                  80  


Phe Gln Lys Leu Ser Glu Pro Leu Asn His Ser Tyr Gln Ala Ile Ile 
                85                  90                  95      


Met Leu Trp Met Ile Ala Asn Gln Ala Asn Leu Trp Leu Ala Ala Cys 
            100                 105                 110         


Leu Ser Leu Leu Tyr Cys Ser Lys Leu Ile Arg Phe Ser His Thr Phe 
        115                 120                 125             


Leu Ile Cys Leu Ala Ser Trp Val Ser Arg Lys Ile Ser Gln Met Leu 
    130                 135                 140                 


Leu Gly Ile Ile Leu Cys Ser Cys Ile Cys Thr Val Leu Cys Val Trp 
145                 150                 155                 160 


Cys Phe Phe Ser Arg Pro His Phe Thr Val Thr Thr Val Leu Phe Met 
                165                 170                 175     


Asn Asn Asn Thr Arg Leu Asn Trp Gln Ile Lys Asp Leu Asn Leu Phe 
            180                 185                 190         


Tyr Ser Phe Leu Phe Cys Tyr Leu Trp Ser Val Pro Pro Phe Leu Leu 
        195                 200                 205             


Phe Leu Val Ser Ser Gly Met Leu Thr Val Ser Leu Gly Arg His Met 
    210                 215                 220                 


Arg Thr Met Lys Val Tyr Thr Arg Asn Ser Arg Asp Pro Ser Leu Glu 
225                 230                 235                 240 


Ala His Ile Lys Ala Leu Lys Ser Leu Val Ser Phe Phe Cys Phe Phe 
                245                 250                 255     


Val Ile Ser Ser Cys Ala Ala Phe Ile Ser Val Pro Leu Leu Ile Leu 
            260                 265                 270         


Trp Arg Asp Lys Ile Gly Val Met Val Cys Val Gly Ile Met Ala Ala 
        275                 280                 285             


Cys Pro Ser Gly His Ala Ala Val Leu Ile Ser Gly Asn Ala Lys Leu 
    290                 295                 300                 


Arg Arg Ala Val Met Thr Ile Leu Leu Trp Ala Gln Ser Ser Leu Lys 
305                 310                 315                 320 


Val Arg Ala Asp His Lys Ala Asp Ser Arg Thr Leu Cys 
                325                 330             


<210> 20
<211> 338
<212> PRT
<213> Homo sapiens

<400> 20
Met Leu Gly Arg Cys Phe Pro Pro Asp Thr Lys Glu Lys Gln Gln Leu 
1               5                   10                  15      


Arg Met Thr Lys Leu Cys Asp Pro Ala Glu Ser Glu Leu Ser Pro Phe 
            20                  25                  30          


Leu Ile Thr Leu Ile Leu Ala Val Leu Leu Ala Glu Tyr Leu Ile Gly 
        35                  40                  45              


Ile Ile Ala Asn Gly Phe Ile Met Ala Ile His Ala Ala Glu Trp Val 
    50                  55                  60                  


Gln Asn Lys Ala Val Ser Thr Ser Gly Arg Ile Leu Val Phe Leu Ser 
65                  70                  75                  80  


Val Ser Arg Ile Ala Leu Gln Ser Leu Met Met Leu Glu Ile Thr Ile 
                85                  90                  95      


Ser Ser Thr Ser Leu Ser Phe Tyr Ser Glu Asp Ala Val Tyr Tyr Ala 
            100                 105                 110         


Phe Lys Ile Ser Phe Ile Phe Leu Asn Phe Cys Ser Leu Trp Phe Ala 
        115                 120                 125             


Ala Trp Leu Ser Phe Phe Tyr Phe Val Lys Ile Ala Asn Phe Ser Tyr 
    130                 135                 140                 


Pro Leu Phe Leu Lys Leu Arg Trp Arg Ile Thr Gly Leu Ile Pro Trp 
145                 150                 155                 160 


Leu Leu Trp Leu Ser Val Phe Ile Ser Phe Ser His Ser Met Phe Cys 
                165                 170                 175     


Ile Asn Ile Cys Thr Val Tyr Cys Asn Asn Ser Phe Pro Ile His Ser 
            180                 185                 190         


Ser Asn Ser Thr Lys Lys Thr Tyr Leu Ser Glu Ile Asn Val Val Gly 
        195                 200                 205             


Leu Ala Phe Phe Phe Asn Leu Gly Ile Val Thr Pro Leu Ile Met Phe 
    210                 215                 220                 


Ile Leu Thr Ala Thr Leu Leu Ile Leu Ser Leu Lys Arg His Thr Leu 
225                 230                 235                 240 


His Met Gly Ser Asn Ala Thr Gly Ser Asn Asp Pro Ser Met Glu Ala 
                245                 250                 255     


His Met Gly Ala Ile Lys Ala Ile Ser Tyr Phe Leu Ile Leu Tyr Ile 
            260                 265                 270         


Phe Asn Ala Val Ala Leu Phe Ile Tyr Leu Ser Asn Met Phe Asp Ile 
        275                 280                 285             


Asn Ser Leu Trp Asn Asn Leu Cys Gln Ile Ile Met Ala Ala Tyr Pro 
    290                 295                 300                 


Ala Ser His Ser Ile Leu Leu Ile Gln Asp Asn Pro Gly Leu Arg Arg 
305                 310                 315                 320 


Ala Trp Lys Arg Leu Gln Leu Arg Leu His Leu Tyr Pro Lys Glu Trp 
                325                 330                 335     


Thr Leu 
        


<210> 21
<211> 323
<212> PRT
<213> Homo sapiens

<400> 21
Met Ala Thr Val Asn Thr Asp Ala Thr Asp Lys Asp Ile Ser Lys Phe 
1               5                   10                  15      


Lys Val Thr Phe Thr Leu Val Val Ser Gly Ile Glu Cys Ile Thr Gly 
            20                  25                  30          


Ile Leu Gly Ser Gly Phe Ile Thr Ala Ile Tyr Gly Ala Glu Trp Ala 
        35                  40                  45              


Arg Gly Lys Thr Leu Pro Thr Gly Asp Arg Ile Met Leu Met Leu Ser 
    50                  55                  60                  


Phe Ser Arg Leu Leu Leu Gln Ile Trp Met Met Leu Glu Asn Ile Phe 
65                  70                  75                  80  


Ser Leu Leu Phe Arg Ile Val Tyr Asn Gln Asn Ser Val Tyr Ile Leu 
                85                  90                  95      


Phe Lys Val Ile Thr Val Phe Leu Asn His Ser Asn Leu Trp Phe Ala 
            100                 105                 110         


Ala Trp Leu Lys Val Phe Tyr Cys Leu Arg Ile Ala Asn Phe Asn His 
        115                 120                 125             


Pro Leu Phe Phe Leu Met Lys Arg Lys Ile Ile Val Leu Met Pro Trp 
    130                 135                 140                 


Leu Leu Arg Leu Ser Val Leu Val Ser Leu Ser Phe Ser Phe Pro Leu 
145                 150                 155                 160 


Ser Arg Asp Val Phe Asn Val Tyr Val Asn Ser Ser Ile Pro Ile Pro 
                165                 170                 175     


Ser Ser Asn Ser Thr Glu Lys Lys Tyr Phe Ser Glu Thr Asn Met Val 
            180                 185                 190         


Asn Leu Val Phe Phe Tyr Asn Met Gly Ile Phe Val Pro Leu Ile Met 
        195                 200                 205             


Phe Ile Leu Ala Ala Thr Leu Leu Ile Leu Ser Leu Lys Arg His Thr 
    210                 215                 220                 


Leu His Met Gly Ser Asn Ala Thr Gly Ser Arg Asp Pro Ser Met Lys 
225                 230                 235                 240 


Ala His Ile Gly Ala Ile Lys Ala Thr Ser Tyr Phe Leu Ile Leu Tyr 
                245                 250                 255     


Ile Phe Asn Ala Ile Ala Leu Phe Leu Ser Thr Ser Asn Ile Phe Asp 
            260                 265                 270         


Thr Tyr Ser Ser Trp Asn Ile Leu Cys Lys Ile Ile Met Ala Ala Tyr 
        275                 280                 285             


Pro Ala Gly His Ser Val Gln Leu Ile Leu Gly Asn Pro Gly Leu Arg 
    290                 295                 300                 


Arg Ala Trp Lys Arg Phe Gln His Gln Val Pro Leu Tyr Leu Lys Gly 
305                 310                 315                 320 


Gln Thr Leu 
            


<210> 22
<211> 307
<212> PRT
<213> Homo sapiens

<400> 22
Met Gln Ala Ala Leu Thr Ala Phe Phe Val Leu Leu Phe Ser Leu Leu 
1               5                   10                  15      


Ser Leu Leu Gly Ile Ala Ala Asn Gly Phe Ile Val Leu Val Leu Gly 
            20                  25                  30          


Arg Glu Trp Leu Arg Tyr Gly Arg Leu Leu Pro Leu Asp Met Ile Leu 
        35                  40                  45              


Ile Ser Leu Gly Ala Ser Arg Phe Cys Leu Gln Leu Val Gly Thr Val 
    50                  55                  60                  


His Asn Phe Tyr Tyr Ser Ala Gln Lys Val Glu Tyr Ser Gly Gly Leu 
65                  70                  75                  80  


Gly Arg Gln Phe Phe His Leu His Trp His Phe Leu Asn Ser Ala Thr 
                85                  90                  95      


Phe Trp Phe Cys Ser Trp Leu Ser Val Leu Phe Cys Val Lys Ile Ala 
            100                 105                 110         


Asn Ile Thr His Ser Thr Phe Leu Trp Leu Lys Trp Arg Phe Pro Gly 
        115                 120                 125             


Trp Val Pro Trp Leu Leu Leu Gly Ser Val Leu Ile Ser Phe Ile Ile 
    130                 135                 140                 


Thr Leu Leu Phe Phe Trp Val Asn Tyr Pro Val Tyr Gln Glu Phe Leu 
145                 150                 155                 160 


Ile Arg Lys Phe Ser Gly Asn Met Thr Tyr Lys Trp Asn Thr Arg Ile 
                165                 170                 175     


Glu Thr Tyr Tyr Phe Pro Ser Leu Lys Leu Val Ile Trp Ser Ile Pro 
            180                 185                 190         


Phe Ser Val Phe Leu Val Ser Ile Met Leu Leu Ile Asn Ser Leu Arg 
        195                 200                 205             


Arg His Thr Gln Arg Met Gln His Asn Gly His Ser Leu Gln Asp Pro 
    210                 215                 220                 


Ser Thr Gln Ala His Thr Arg Ala Leu Lys Ser Leu Ile Ser Phe Leu 
225                 230                 235                 240 


Ile Leu Tyr Ala Leu Ser Phe Leu Ser Leu Ile Ile Asp Ala Ala Lys 
                245                 250                 255     


Phe Ile Ser Met Gln Asn Asp Phe Tyr Trp Pro Trp Gln Ile Ala Val 
            260                 265                 270         


Tyr Leu Cys Ile Ser Val His Pro Phe Ile Leu Ile Phe Ser Asn Leu 
        275                 280                 285             


Lys Leu Arg Ser Val Phe Ser Gln Leu Leu Leu Leu Ala Arg Gly Phe 
    290                 295                 300                 


Trp Val Ala 
305         


<210> 23
<211> 314
<212> PRT
<213> Homo sapiens

<400> 23
Met Ala Thr Glu Leu Asp Lys Ile Phe Leu Ile Leu Ala Ile Ala Glu 
1               5                   10                  15      


Phe Ile Ile Ser Met Leu Gly Asn Val Phe Ile Gly Leu Val Asn Cys 
            20                  25                  30          


Ser Glu Gly Ile Lys Asn Gln Lys Val Phe Ser Ala Asp Phe Ile Leu 
        35                  40                  45              


Thr Cys Leu Ala Ile Ser Thr Ile Gly Gln Leu Leu Val Ile Leu Phe 
    50                  55                  60                  


Asp Ser Phe Leu Val Gly Leu Ala Ser His Leu Tyr Thr Thr Tyr Arg 
65                  70                  75                  80  


Leu Gly Lys Thr Val Ile Met Leu Trp His Met Thr Asn His Leu Thr 
                85                  90                  95      


Thr Trp Leu Ala Thr Cys Leu Ser Ile Phe Tyr Phe Phe Lys Ile Ala 
            100                 105                 110         


His Phe Pro His Ser Leu Phe Leu Trp Leu Arg Trp Arg Met Asn Gly 
        115                 120                 125             


Met Ile Val Met Leu Leu Ile Leu Ser Leu Phe Leu Leu Ile Phe Asp 
    130                 135                 140                 


Ser Leu Val Leu Glu Ile Phe Ile Asp Ile Ser Leu Asn Ile Ile Asp 
145                 150                 155                 160 


Lys Ser Asn Leu Thr Leu Tyr Leu Asp Glu Ser Lys Thr Leu Tyr Asp 
                165                 170                 175     


Lys Leu Ser Ile Leu Lys Thr Leu Leu Ser Leu Thr Ser Phe Ile Pro 
            180                 185                 190         


Phe Ser Leu Phe Leu Thr Ser Leu Leu Phe Leu Phe Leu Ser Leu Val 
        195                 200                 205             


Arg His Thr Arg Asn Leu Lys Leu Ser Ser Leu Gly Ser Arg Asp Ser 
    210                 215                 220                 


Ser Thr Glu Ala His Arg Arg Ala Met Lys Met Val Met Ser Phe Leu 
225                 230                 235                 240 


Phe Leu Phe Ile Val His Phe Phe Ser Leu Gln Val Ala Asn Gly Ile 
                245                 250                 255     


Phe Phe Met Leu Trp Asn Asn Lys Tyr Ile Lys Phe Val Met Leu Ala 
            260                 265                 270         


Leu Asn Ala Phe Pro Ser Cys His Ser Phe Ile Leu Ile Leu Gly Asn 
        275                 280                 285             


Ser Lys Leu Arg Gln Thr Ala Val Arg Leu Leu Trp His Leu Arg Asn 
    290                 295                 300                 


Tyr Thr Lys Thr Pro Asn Ala Leu Pro Leu 
305                 310                 


<210> 24
<211> 309
<212> PRT
<213> Homo sapiens

<400> 24
Met Ile Thr Phe Leu Pro Ile Ile Phe Ser Ser Leu Val Val Val Thr 
1               5                   10                  15      


Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser 
            20                  25                  30          


Ile Glu Trp Phe Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Leu 
        35                  40                  45              


Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Leu Leu 
    50                  55                  60                  


Asn Trp Tyr Ser Thr Val Leu Asn Pro Ala Phe Asn Ser Val Glu Val 
65                  70                  75                  80  


Arg Thr Thr Ala Tyr Asn Ile Trp Ala Val Ile Asn His Phe Ser Asn 
                85                  90                  95      


Trp Leu Ala Thr Thr Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn 
            100                 105                 110         


Phe Ser Asn Phe Ile Phe Leu His Leu Lys Arg Arg Val Lys Ser Val 
        115                 120                 125             


Ile Leu Val Met Leu Leu Gly Pro Leu Leu Phe Leu Ala Cys His Leu 
    130                 135                 140                 


Phe Val Ile Asn Met Asn Glu Ile Val Arg Thr Lys Glu Phe Glu Gly 
145                 150                 155                 160 


Asn Met Thr Trp Lys Ile Lys Leu Lys Ser Ala Met Tyr Phe Ser Asn 
                165                 170                 175     


Met Thr Val Thr Met Val Ala Asn Leu Val Pro Phe Thr Leu Thr Leu 
            180                 185                 190         


Leu Ser Phe Met Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys 
        195                 200                 205             


Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His 
    210                 215                 220                 


Ile Lys Ala Leu Gln Thr Val Ile Ser Phe Leu Leu Leu Cys Ala Ile 
225                 230                 235                 240 


Tyr Phe Leu Ser Ile Met Ile Ser Val Trp Ser Phe Gly Ser Leu Glu 
                245                 250                 255     


Asn Lys Pro Val Phe Met Phe Cys Lys Ala Ile Arg Phe Ser Tyr Pro 
            260                 265                 270         


Ser Ile His Pro Phe Ile Leu Ile Trp Gly Asn Lys Lys Leu Lys Gln 
        275                 280                 285             


Thr Phe Leu Ser Val Phe Trp Gln Met Arg Tyr Trp Val Lys Gly Glu 
    290                 295                 300                 


Lys Thr Ser Ser Pro 
305                 


<210> 25
<211> 309
<212> PRT
<213> Homo sapiens

<400> 25
Met Thr Thr Phe Ile Pro Ile Ile Phe Ser Ser Val Val Val Val Leu 
1               5                   10                  15      


Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser 
            20                  25                  30          


Ile Glu Arg Val Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Leu 
        35                  40                  45              


Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Leu Leu 
    50                  55                  60                  


Asn Trp Tyr Ser Thr Val Phe Asn Pro Ala Phe Tyr Ser Val Glu Val 
65                  70                  75                  80  


Arg Thr Thr Ala Tyr Asn Val Trp Ala Val Thr Gly His Phe Ser Asn 
                85                  90                  95      


Trp Leu Ala Thr Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn 
            100                 105                 110         


Phe Ser Asn Leu Ile Phe Leu His Leu Lys Arg Arg Val Lys Ser Val 
        115                 120                 125             


Ile Leu Val Met Leu Leu Gly Pro Leu Leu Phe Leu Ala Cys Gln Leu 
    130                 135                 140                 


Phe Val Ile Asn Met Lys Glu Ile Val Arg Thr Lys Glu Tyr Glu Gly 
145                 150                 155                 160 


Asn Met Thr Trp Lys Ile Lys Leu Arg Ser Ala Val Tyr Leu Ser Asp 
                165                 170                 175     


Ala Thr Val Thr Thr Leu Gly Asn Leu Val Pro Phe Thr Leu Thr Leu 
            180                 185                 190         


Leu Cys Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys 
        195                 200                 205             


Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His 
    210                 215                 220                 


Ile Lys Ala Leu Gln Thr Val Ile Phe Phe Leu Leu Leu Cys Ala Val 
225                 230                 235                 240 


Tyr Phe Leu Ser Ile Met Ile Ser Val Trp Ser Phe Gly Ser Leu Glu 
                245                 250                 255     


Asn Lys Pro Val Phe Met Phe Cys Lys Ala Ile Arg Phe Ser Tyr Pro 
            260                 265                 270         


Ser Ile His Pro Phe Ile Leu Ile Trp Gly Asn Lys Lys Leu Lys Gln 
        275                 280                 285             


Thr Phe Leu Ser Val Leu Arg Gln Val Arg Tyr Trp Val Lys Gly Glu 
    290                 295                 300                 


Lys Pro Ser Ser Pro 
305                 


<210> 26
<211> 299
<212> PRT
<213> Homo sapiens

<400> 26
Met Ile Thr Phe Leu Pro Ile Ile Phe Ser Ile Leu Val Val Val Thr 
1               5                   10                  15      


Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser 
            20                  25                  30          


Thr Glu Trp Val Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Val 
        35                  40                  45              


Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Leu Leu 
    50                  55                  60                  


Asn Trp Tyr Ser Thr Val Leu Asn Pro Ala Phe Tyr Ser Val Glu Leu 
65                  70                  75                  80  


Arg Thr Thr Ala Tyr Asn Ile Trp Ala Val Thr Gly His Phe Ser Asn 
                85                  90                  95      


Trp Pro Ala Thr Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn 
            100                 105                 110         


Phe Ser Asn Leu Ile Phe Leu Arg Leu Lys Arg Arg Val Lys Ser Val 
        115                 120                 125             


Ile Leu Val Val Leu Leu Gly Pro Leu Leu Phe Leu Ala Cys His Leu 
    130                 135                 140                 


Phe Val Val Asn Met Asn Gln Ile Val Trp Thr Lys Glu Tyr Glu Gly 
145                 150                 155                 160 


Asn Met Thr Trp Lys Ile Lys Leu Arg Arg Ala Met Tyr Leu Ser Asp 
                165                 170                 175     


Thr Thr Val Thr Met Leu Ala Asn Leu Val Pro Phe Thr Val Thr Leu 
            180                 185                 190         


Ile Ser Phe Leu Leu Leu Val Cys Ser Leu Cys Lys His Leu Lys Lys 
        195                 200                 205             


Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His 
    210                 215                 220                 


Ile Lys Val Leu Gln Thr Val Ile Ser Phe Phe Leu Leu Cys Ala Ile 
225                 230                 235                 240 


Tyr Phe Val Ser Val Ile Ile Ser Val Trp Ser Phe Lys Asn Leu Glu 
                245                 250                 255     


Asn Lys Pro Val Phe Met Phe Cys Gln Ala Ile Gly Phe Ser Cys Ser 
            260                 265                 270         


Ser Ala His Pro Phe Ile Leu Ile Trp Gly Asn Lys Lys Leu Lys Gln 
        275                 280                 285             


Thr Tyr Leu Ser Val Leu Trp Gln Met Arg Tyr 
    290                 295                 


<210> 27
<211> 309
<212> PRT
<213> Homo sapiens

<400> 27
Met Ile Thr Phe Leu Pro Ile Ile Phe Ser Ile Leu Ile Val Val Thr 
1               5                   10                  15      


Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser 
            20                  25                  30          


Ile Glu Trp Phe Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Leu 
        35                  40                  45              


Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Val Leu 
    50                  55                  60                  


Asn Trp Tyr Ala Thr Glu Leu Asn Pro Ala Phe Asn Ser Ile Glu Val 
65                  70                  75                  80  


Arg Ile Thr Ala Tyr Asn Val Trp Ala Val Ile Asn His Phe Ser Asn 
                85                  90                  95      


Trp Leu Ala Thr Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn 
            100                 105                 110         


Phe Ser Asn Leu Ile Phe Leu His Leu Lys Arg Arg Val Lys Ser Val 
        115                 120                 125             


Val Leu Val Ile Leu Leu Gly Pro Leu Leu Phe Leu Val Cys His Leu 
    130                 135                 140                 


Phe Val Ile Asn Met Asn Gln Ile Ile Trp Thr Lys Glu Tyr Glu Gly 
145                 150                 155                 160 


Asn Met Thr Trp Lys Ile Lys Leu Arg Ser Ala Met Tyr Leu Ser Asn 
                165                 170                 175     


Thr Thr Val Thr Ile Leu Ala Asn Leu Val Pro Phe Thr Leu Thr Leu 
            180                 185                 190         


Ile Ser Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys 
        195                 200                 205             


Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Met Lys Val His 
    210                 215                 220                 


Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Leu Leu Cys Ala Ile 
225                 230                 235                 240 


Tyr Phe Leu Ser Ile Ile Met Ser Val Trp Ser Phe Glu Ser Leu Glu 
                245                 250                 255     


Asn Lys Pro Val Phe Met Phe Cys Glu Ala Ile Ala Phe Ser Tyr Pro 
            260                 265                 270         


Ser Thr His Pro Phe Ile Leu Ile Trp Gly Asn Lys Lys Leu Lys Gln 
        275                 280                 285             


Thr Phe Leu Ser Val Leu Trp His Val Arg Tyr Trp Val Lys Gly Glu 
    290                 295                 300                 


Lys Pro Ser Ser Ser 
305                 


<210> 28
<211> 309
<212> PRT
<213> Homo sapiens

<400> 28
Met Met Ser Phe Leu His Ile Val Phe Ser Ile Leu Val Val Val Ala 
1               5                   10                  15      


Phe Ile Leu Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Ile Asn Phe 
            20                  25                  30          


Ile Ala Trp Val Lys Arg Gln Lys Ile Ser Ser Ala Asp Gln Ile Ile 
        35                  40                  45              


Ala Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Ile Leu Leu 
    50                  55                  60                  


His Trp Tyr Ser Thr Val Leu Asn Pro Thr Ser Ser Asn Leu Lys Val 
65                  70                  75                  80  


Ile Ile Phe Ile Ser Asn Ala Trp Ala Val Thr Asn His Phe Ser Ile 
                85                  90                  95      


Trp Leu Ala Thr Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Val Asn 
            100                 105                 110         


Phe Ser Arg Leu Ile Phe His His Leu Lys Arg Lys Ala Lys Ser Val 
        115                 120                 125             


Val Leu Val Ile Val Leu Gly Ser Leu Phe Phe Leu Val Cys His Leu 
    130                 135                 140                 


Val Met Lys His Thr Tyr Ile Asn Val Trp Thr Glu Glu Cys Glu Gly 
145                 150                 155                 160 


Asn Val Thr Trp Lys Ile Lys Leu Arg Asn Ala Met His Leu Ser Asn 
                165                 170                 175     


Leu Thr Val Ala Met Leu Ala Asn Leu Ile Pro Phe Thr Leu Thr Leu 
            180                 185                 190         


Ile Ser Phe Leu Leu Leu Ile Tyr Ser Leu Cys Lys His Leu Lys Lys 
        195                 200                 205             


Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Ile His 
    210                 215                 220                 


Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Ile Leu Leu Ala Ile 
225                 230                 235                 240 


Tyr Phe Leu Cys Leu Ile Ile Ser Phe Trp Asn Phe Lys Met Leu Pro 
                245                 250                 255     


Lys Glu Ile Val Leu Met Leu Cys Gln Ala Phe Gly Ile Ile Tyr Pro 
            260                 265                 270         


Ser Phe His Ser Phe Ile Leu Ile Trp Gly Asn Lys Thr Leu Lys Gln 
        275                 280                 285             


Thr Phe Leu Ser Val Leu Trp Gln Val Thr Cys Trp Ala Lys Gly Gln 
    290                 295                 300                 


Asn Gln Ser Thr Pro 
305                 


<210> 29
<211> 299
<212> PRT
<213> Homo sapiens

<400> 29
Met Ile Thr Phe Leu Tyr Ile Phe Phe Ser Ile Leu Ile Met Val Leu 
1               5                   10                  15      


Phe Val Leu Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Phe 
            20                  25                  30          


Ile Asp Trp Val Lys Arg Lys Lys Ile Ser Ser Ala Asp Gln Ile Leu 
        35                  40                  45              


Thr Ala Leu Ala Val Ser Arg Ile Gly Leu Leu Trp Ala Leu Leu Leu 
    50                  55                  60                  


Asn Trp Tyr Leu Thr Val Leu Asn Pro Ala Phe Tyr Ser Val Glu Leu 
65                  70                  75                  80  


Arg Ile Thr Ser Tyr Asn Ala Trp Val Val Thr Asn His Phe Ser Met 
                85                  90                  95      


Trp Leu Ala Ala Asn Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn 
            100                 105                 110         


Phe Ser Asn Leu Leu Phe Leu His Leu Lys Arg Arg Val Arg Ser Val 
        115                 120                 125             


Ile Leu Val Ile Leu Leu Gly Thr Leu Ile Phe Leu Val Cys His Leu 
    130                 135                 140                 


Leu Val Ala Asn Met Asp Glu Ser Met Trp Ala Glu Glu Tyr Glu Gly 
145                 150                 155                 160 


Asn Met Thr Gly Lys Met Lys Leu Arg Asn Thr Val His Leu Ser Tyr 
                165                 170                 175     


Leu Thr Val Thr Thr Leu Trp Ser Phe Ile Pro Phe Thr Leu Ser Leu 
            180                 185                 190         


Ile Ser Phe Leu Met Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys 
        195                 200                 205             


Met Gln Leu His Gly Glu Gly Ser Gln Asp Leu Ser Thr Lys Val His 
    210                 215                 220                 


Ile Lys Ala Leu Gln Thr Leu Ile Ser Phe Leu Leu Leu Cys Ala Ile 
225                 230                 235                 240 


Phe Phe Leu Phe Leu Ile Val Ser Val Trp Ser Pro Arg Arg Leu Arg 
                245                 250                 255     


Asn Asp Pro Val Val Met Val Ser Lys Ala Val Gly Asn Ile Tyr Leu 
            260                 265                 270         


Ala Phe Asp Ser Phe Ile Leu Ile Trp Arg Thr Lys Lys Leu Lys His 
        275                 280                 285             


Thr Phe Leu Leu Ile Leu Cys Gln Ile Arg Cys 
    290                 295                 


<210> 30
<211> 318
<212> PRT
<213> Homo sapiens

<400> 30
Met Asn Gly Asp His Met Val Leu Gly Ser Ser Val Thr Asp Lys Lys 
1               5                   10                  15      


Ala Ile Ile Leu Val Thr Ile Leu Leu Leu Leu Arg Leu Val Ala Ile 
            20                  25                  30          


Ala Gly Asn Gly Phe Ile Thr Ala Ala Leu Gly Val Glu Trp Val Leu 
        35                  40                  45              


Arg Arg Met Leu Leu Pro Cys Asp Lys Leu Leu Val Ser Leu Gly Ala 
    50                  55                  60                  


Ser Arg Phe Cys Leu Gln Ser Val Val Met Gly Lys Thr Ile Tyr Val 
65                  70                  75                  80  


Phe Leu His Pro Met Ala Phe Pro Tyr Asn Pro Val Leu Gln Phe Leu 
                85                  90                  95      


Ala Phe Gln Trp Asp Phe Leu Asn Ala Ala Thr Leu Trp Ser Ser Thr 
            100                 105                 110         


Trp Leu Ser Val Phe Tyr Cys Val Lys Ile Ala Thr Phe Thr His Pro 
        115                 120                 125             


Val Phe Phe Trp Leu Lys His Lys Leu Ser Gly Trp Leu Pro Trp Met 
    130                 135                 140                 


Leu Phe Ser Ser Val Gly Leu Ser Ser Phe Thr Thr Ile Leu Phe Phe 
145                 150                 155                 160 


Ile Gly Asn His Arg Met Tyr Gln Asn Tyr Leu Arg Asn His Leu Gln 
                165                 170                 175     


Pro Trp Asn Val Thr Gly Asp Ser Ile Arg Ser Tyr Cys Glu Lys Phe 
            180                 185                 190         


Tyr Leu Phe Pro Leu Lys Met Ile Thr Trp Thr Met Pro Thr Ala Val 
        195                 200                 205             


Phe Phe Ile Cys Met Ile Leu Leu Ile Thr Ser Leu Gly Arg His Arg 
    210                 215                 220                 


Lys Lys Ala Leu Leu Thr Thr Ser Gly Phe Arg Glu Pro Ser Val Gln 
225                 230                 235                 240 


Ala His Ile Lys Ala Leu Leu Ala Leu Leu Ser Phe Ala Met Leu Phe 
                245                 250                 255     


Ile Ser Tyr Phe Leu Ser Leu Val Phe Ser Ala Ala Gly Ile Phe Pro 
            260                 265                 270         


Pro Leu Asp Phe Lys Phe Trp Val Trp Glu Ser Val Ile Tyr Leu Cys 
        275                 280                 285             


Ala Ala Val His Pro Ile Ile Leu Leu Phe Ser Asn Cys Arg Leu Arg 
    290                 295                 300                 


Ala Val Leu Lys Ser Arg Arg Ser Ser Arg Cys Gly Thr Pro 
305                 310                 315             


<210> 31
<211> 890
<212> PRT
<213> Homo sapiens

<400> 31
Met Glu Gly Gly Gly Lys Pro Asn Ser Ser Ser Asn Ser Arg Asp Asp 
1               5                   10                  15      


Gly Asn Ser Val Phe Pro Ala Lys Ala Ser Ala Thr Gly Ala Gly Pro 
            20                  25                  30          


Ala Ala Ala Glu Lys Arg Leu Gly Thr Pro Pro Gly Gly Gly Gly Ala 
        35                  40                  45              


Gly Ala Lys Glu His Gly Asn Ser Val Cys Phe Lys Val Asp Gly Gly 
    50                  55                  60                  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Glu Pro Ala Gly Gly 
65                  70                  75                  80  


Phe Glu Asp Ala Glu Gly Pro Arg Arg Gln Tyr Gly Phe Met Gln Arg 
                85                  90                  95      


Gln Phe Thr Ser Met Leu Gln Pro Gly Val Asn Lys Phe Ser Leu Arg 
            100                 105                 110         


Met Phe Gly Ser Gln Lys Ala Val Glu Lys Glu Gln Glu Arg Val Lys 
        115                 120                 125             


Thr Ala Gly Phe Trp Ile Ile His Pro Tyr Ser Asp Phe Arg Phe Tyr 
    130                 135                 140                 


Trp Asp Leu Ile Met Leu Ile Met Met Val Gly Asn Leu Val Ile Ile 
145                 150                 155                 160 


Pro Val Gly Ile Thr Phe Phe Thr Glu Gln Thr Thr Thr Pro Trp Ile 
                165                 170                 175     


Ile Phe Asn Val Ala Ser Asp Thr Val Phe Leu Leu Asp Leu Ile Met 
            180                 185                 190         


Asn Phe Arg Thr Gly Thr Val Asn Glu Asp Ser Ser Glu Ile Ile Leu 
        195                 200                 205             


Asp Pro Lys Val Ile Lys Met Asn Tyr Leu Lys Ser Trp Phe Val Val 
    210                 215                 220                 


Asp Phe Ile Ser Ser Ile Pro Val Asp Tyr Ile Phe Leu Ile Val Glu 
225                 230                 235                 240 


Lys Gly Met Asp Ser Glu Val Tyr Lys Thr Ala Arg Ala Leu Arg Ile 
                245                 250                 255     


Val Arg Phe Thr Lys Ile Leu Ser Leu Leu Arg Leu Leu Arg Leu Ser 
            260                 265                 270         


Arg Leu Ile Arg Tyr Ile His Gln Trp Glu Glu Ile Phe His Met Thr 
        275                 280                 285             


Tyr Asp Leu Ala Ser Ala Val Val Arg Ile Phe Asn Leu Ile Gly Met 
    290                 295                 300                 


Met Leu Leu Leu Cys His Trp Asp Gly Cys Leu Gln Phe Leu Val Pro 
305                 310                 315                 320 


Leu Leu Gln Asp Phe Pro Pro Asp Cys Trp Val Ser Leu Asn Glu Met 
                325                 330                 335     


Val Asn Asp Ser Trp Gly Lys Gln Tyr Ser Tyr Ala Leu Phe Lys Ala 
            340                 345                 350         


Met Ser His Met Leu Cys Ile Gly Tyr Gly Ala Gln Ala Pro Val Ser 
        355                 360                 365             


Met Ser Asp Leu Trp Ile Thr Met Leu Ser Met Ile Val Gly Ala Thr 
    370                 375                 380                 


Cys Tyr Ala Met Phe Val Gly His Ala Thr Ala Leu Ile Gln Ser Leu 
385                 390                 395                 400 


Asp Ser Ser Arg Arg Gln Tyr Gln Glu Lys Tyr Lys Gln Val Glu Gln 
                405                 410                 415     


Tyr Met Ser Phe His Lys Leu Pro Ala Asp Met Arg Gln Lys Ile His 
            420                 425                 430         


Asp Tyr Tyr Glu His Arg Tyr Gln Gly Lys Ile Phe Asp Glu Glu Asn 
        435                 440                 445             


Ile Leu Asn Glu Leu Asn Asp Pro Leu Arg Glu Glu Ile Val Asn Phe 
    450                 455                 460                 


Asn Cys Arg Lys Leu Val Ala Thr Met Pro Leu Phe Ala Asn Ala Asp 
465                 470                 475                 480 


Pro Asn Phe Val Thr Ala Met Leu Ser Lys Leu Arg Phe Glu Val Phe 
                485                 490                 495     


Gln Pro Gly Asp Tyr Ile Ile Arg Glu Gly Ala Val Gly Lys Lys Met 
            500                 505                 510         


Tyr Phe Ile Gln His Gly Val Ala Gly Val Ile Thr Lys Ser Ser Lys 
        515                 520                 525             


Glu Met Lys Leu Thr Asp Gly Ser Tyr Phe Gly Glu Ile Cys Leu Leu 
    530                 535                 540                 


Thr Lys Gly Arg Arg Thr Ala Ser Val Arg Ala Asp Thr Tyr Cys Arg 
545                 550                 555                 560 


Leu Tyr Ser Leu Ser Val Asp Asn Phe Asn Glu Val Leu Glu Glu Tyr 
                565                 570                 575     


Pro Met Met Arg Arg Ala Phe Glu Thr Val Ala Ile Asp Arg Leu Asp 
            580                 585                 590         


Arg Ile Gly Lys Lys Asn Ser Ile Leu Leu Gln Lys Phe Gln Lys Asp 
        595                 600                 605             


Leu Asn Thr Gly Val Phe Asn Asn Gln Glu Asn Glu Ile Leu Lys Gln 
    610                 615                 620                 


Ile Val Lys His Asp Arg Glu Met Val Gln Ala Ile Ala Pro Ile Asn 
625                 630                 635                 640 


Tyr Pro Gln Met Thr Thr Leu Asn Ser Thr Ser Ser Thr Thr Thr Pro 
                645                 650                 655     


Thr Ser Arg Met Arg Thr Gln Ser Pro Pro Val Tyr Thr Ala Thr Ser 
            660                 665                 670         


Leu Ser His Ser Asn Leu His Ser Pro Ser Pro Ser Thr Gln Thr Pro 
        675                 680                 685             


Gln Pro Ser Ala Ile Leu Ser Pro Cys Ser Tyr Thr Thr Ala Val Cys 
    690                 695                 700                 


Ser Pro Pro Val Gln Ser Pro Leu Ala Ala Arg Thr Phe His Tyr Ala 
705                 710                 715                 720 


Ser Pro Thr Ala Ser Gln Leu Ser Leu Met Gln Gln Gln Pro Gln Gln 
                725                 730                 735     


Gln Val Gln Gln Ser Gln Pro Pro Gln Thr Gln Pro Gln Gln Pro Ser 
            740                 745                 750         


Pro Gln Pro Gln Thr Pro Gly Ser Ser Thr Pro Lys Asn Glu Val His 
        755                 760                 765             


Lys Ser Thr Gln Ala Leu His Asn Thr Asn Leu Thr Arg Glu Val Arg 
    770                 775                 780                 


Pro Leu Ser Ala Ser Gln Pro Ser Leu Pro His Glu Val Ser Thr Leu 
785                 790                 795                 800 


Ile Ser Arg Pro His Pro Thr Val Gly Glu Ser Leu Ala Ser Ile Pro 
                805                 810                 815     


Gln Pro Val Thr Ala Val Pro Gly Thr Gly Leu Gln Ala Gly Gly Arg 
            820                 825                 830         


Ser Thr Val Pro Gln Arg Val Thr Leu Phe Arg Gln Met Ser Ser Gly 
        835                 840                 845             


Ala Ile Pro Pro Asn Arg Gly Val Pro Pro Ala Pro Pro Pro Pro Ala 
    850                 855                 860                 


Ala Ala Leu Pro Arg Glu Ser Ser Ser Val Leu Asn Thr Asp Pro Asp 
865                 870                 875                 880 


Ala Glu Lys Pro Arg Phe Ala Ser Asn Leu 
                885                 890 


<210> 32
<211> 1203
<212> PRT
<213> Homo sapiens

<400> 32
Met Asp Lys Leu Pro Pro Ser Met Arg Lys Arg Leu Tyr Ser Leu Pro 
1               5                   10                  15      


Gln Gln Val Gly Ala Lys Ala Trp Ile Met Asp Glu Glu Glu Asp Ala 
            20                  25                  30          


Glu Glu Glu Gly Ala Gly Gly Arg Gln Asp Pro Ser Arg Arg Ser Ile 
        35                  40                  45              


Arg Leu Arg Pro Leu Pro Ser Pro Ser Pro Ser Ala Ala Ala Gly Gly 
    50                  55                  60                  


Thr Glu Ser Arg Ser Ser Ala Leu Gly Ala Ala Asp Ser Glu Gly Pro 
65                  70                  75                  80  


Ala Arg Gly Ala Gly Lys Ser Ser Thr Asn Gly Asp Cys Arg Arg Phe 
                85                  90                  95      


Arg Gly Ser Leu Ala Ser Leu Gly Ser Arg Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Thr Gly Ser Gly Ser Ser His Gly His Leu His Asp Ser Ala Glu Glu 
        115                 120                 125             


Arg Arg Leu Ile Ala Glu Gly Asp Ala Ser Pro Gly Glu Asp Arg Thr 
    130                 135                 140                 


Pro Pro Gly Leu Ala Ala Glu Pro Glu Arg Pro Gly Ala Ser Ala Gln 
145                 150                 155                 160 


Pro Ala Ala Ser Pro Pro Pro Pro Gln Gln Pro Pro Gln Pro Ala Ser 
                165                 170                 175     


Ala Ser Cys Glu Gln Pro Ser Val Asp Thr Ala Ile Lys Val Glu Gly 
            180                 185                 190         


Gly Ala Ala Ala Gly Asp Gln Ile Leu Pro Glu Ala Glu Val Arg Leu 
        195                 200                 205             


Gly Gln Ala Gly Phe Met Gln Arg Gln Phe Gly Ala Met Leu Gln Pro 
    210                 215                 220                 


Gly Val Asn Lys Phe Ser Leu Arg Met Phe Gly Ser Gln Lys Ala Val 
225                 230                 235                 240 


Glu Arg Glu Gln Glu Arg Val Lys Ser Ala Gly Phe Trp Ile Ile His 
                245                 250                 255     


Pro Tyr Ser Asp Phe Arg Phe Tyr Trp Asp Leu Thr Met Leu Leu Leu 
            260                 265                 270         


Met Val Gly Asn Leu Ile Ile Ile Pro Val Gly Ile Thr Phe Phe Lys 
        275                 280                 285             


Asp Glu Asn Thr Thr Pro Trp Ile Val Phe Asn Val Val Ser Asp Thr 
    290                 295                 300                 


Phe Phe Leu Ile Asp Leu Val Leu Asn Phe Arg Thr Gly Ile Val Val 
305                 310                 315                 320 


Glu Asp Asn Thr Glu Ile Ile Leu Asp Pro Gln Arg Ile Lys Met Lys 
                325                 330                 335     


Tyr Leu Lys Ser Trp Phe Met Val Asp Phe Ile Ser Ser Ile Pro Val 
            340                 345                 350         


Asp Tyr Ile Phe Leu Ile Val Glu Thr Arg Ile Asp Ser Glu Val Tyr 
        355                 360                 365             


Lys Thr Ala Arg Ala Leu Arg Ile Val Arg Phe Thr Lys Ile Leu Ser 
    370                 375                 380                 


Leu Leu Arg Leu Leu Arg Leu Ser Arg Leu Ile Arg Tyr Ile His Gln 
385                 390                 395                 400 


Trp Glu Glu Ile Phe His Met Thr Tyr Asp Leu Ala Ser Ala Val Val 
                405                 410                 415     


Arg Ile Val Asn Leu Ile Gly Met Met Leu Leu Leu Cys His Trp Asp 
            420                 425                 430         


Gly Cys Leu Gln Phe Leu Val Pro Met Leu Gln Asp Phe Pro Asp Asp 
        435                 440                 445             


Cys Trp Val Ser Ile Asn Asn Met Val Asn Asn Ser Trp Gly Lys Gln 
    450                 455                 460                 


Tyr Ser Tyr Ala Leu Phe Lys Ala Met Ser His Met Leu Cys Ile Gly 
465                 470                 475                 480 


Tyr Gly Arg Gln Ala Pro Val Gly Met Ser Asp Val Trp Leu Thr Met 
                485                 490                 495     


Leu Ser Met Ile Val Gly Ala Thr Cys Tyr Ala Met Phe Ile Gly His 
            500                 505                 510         


Ala Thr Ala Leu Ile Gln Ser Leu Asp Ser Ser Arg Arg Gln Tyr Gln 
        515                 520                 525             


Glu Lys Tyr Lys Gln Val Glu Gln Tyr Met Ser Phe His Lys Leu Pro 
    530                 535                 540                 


Pro Asp Thr Arg Gln Arg Ile His Asp Tyr Tyr Glu His Arg Tyr Gln 
545                 550                 555                 560 


Gly Lys Met Phe Asp Glu Glu Ser Ile Leu Gly Glu Leu Ser Glu Pro 
                565                 570                 575     


Leu Arg Glu Glu Ile Ile Asn Phe Asn Cys Arg Lys Leu Val Ala Ser 
            580                 585                 590         


Met Pro Leu Phe Ala Asn Ala Asp Pro Asn Phe Val Thr Ser Met Leu 
        595                 600                 605             


Thr Lys Leu Arg Phe Glu Val Phe Gln Pro Gly Asp Tyr Ile Ile Arg 
    610                 615                 620                 


Glu Gly Thr Ile Gly Lys Lys Met Tyr Phe Ile Gln His Gly Val Val 
625                 630                 635                 640 


Ser Val Leu Thr Lys Gly Asn Lys Glu Thr Lys Leu Ala Asp Gly Ser 
                645                 650                 655     


Tyr Phe Gly Glu Ile Cys Leu Leu Thr Arg Gly Arg Arg Thr Ala Ser 
            660                 665                 670         


Val Arg Ala Asp Thr Tyr Cys Arg Leu Tyr Ser Leu Ser Val Asp Asn 
        675                 680                 685             


Phe Asn Glu Val Leu Glu Glu Tyr Pro Met Met Arg Arg Ala Phe Glu 
    690                 695                 700                 


Thr Val Ala Leu Asp Arg Leu Asp Arg Ile Gly Lys Lys Asn Ser Ile 
705                 710                 715                 720 


Leu Leu His Lys Val Gln His Asp Leu Asn Ser Gly Val Phe Asn Tyr 
                725                 730                 735     


Gln Glu Asn Glu Ile Ile Gln Gln Ile Val Gln His Asp Arg Glu Met 
            740                 745                 750         


Ala His Cys Ala His Arg Val Gln Ala Ala Ala Ser Ala Thr Pro Thr 
        755                 760                 765             


Pro Thr Pro Val Ile Trp Thr Pro Leu Ile Gln Ala Pro Leu Gln Ala 
    770                 775                 780                 


Ala Ala Ala Thr Thr Ser Val Ala Ile Ala Leu Thr His His Pro Arg 
785                 790                 795                 800 


Leu Pro Ala Ala Ile Phe Arg Pro Pro Pro Gly Ser Gly Leu Gly Asn 
                805                 810                 815     


Leu Gly Ala Gly Gln Thr Pro Arg His Leu Lys Arg Leu Gln Ser Leu 
            820                 825                 830         


Ile Pro Ser Ala Leu Gly Ser Ala Ser Pro Ala Ser Ser Pro Ser Gln 
        835                 840                 845             


Val Asp Thr Pro Ser Ser Ser Ser Phe His Ile Gln Gln Leu Ala Gly 
    850                 855                 860                 


Phe Ser Ala Pro Ala Gly Leu Ser Pro Leu Leu Pro Ser Ser Ser Ser 
865                 870                 875                 880 


Ser Pro Pro Pro Gly Ala Cys Gly Ser Pro Ser Ala Pro Thr Pro Ser 
                885                 890                 895     


Ala Gly Val Ala Ala Thr Thr Ile Ala Gly Phe Gly His Phe His Lys 
            900                 905                 910         


Ala Leu Gly Gly Ser Leu Ser Ser Ser Asp Ser Pro Leu Leu Thr Pro 
        915                 920                 925             


Leu Gln Pro Gly Ala Arg Ser Pro Gln Ala Ala Gln Pro Ser Pro Ala 
    930                 935                 940                 


Pro Pro Gly Ala Arg Gly Gly Leu Gly Leu Pro Glu His Phe Leu Pro 
945                 950                 955                 960 


Pro Pro Pro Ser Ser Arg Ser Pro Ser Ser Ser Pro Gly Gln Leu Gly 
                965                 970                 975     


Gln Pro Pro Gly Glu Leu Ser Leu Gly Leu Ala Thr Gly Pro Leu Ser 
            980                 985                 990         


Thr Pro Glu Thr Pro Pro Arg Gln  Pro Glu Pro Pro Ser  Leu Val Ala 
        995                 1000                 1005             


Gly Ala  Ser Gly Gly Ala Ser  Pro Val Gly Phe Thr  Pro Arg Gly 
    1010                 1015                 1020             


Gly Leu  Ser Pro Pro Gly His  Ser Pro Gly Pro Pro  Arg Thr Phe 
    1025                 1030                 1035             


Pro Ser  Ala Pro Pro Arg Ala  Ser Gly Ser His Gly  Ser Leu Leu 
    1040                 1045                 1050             


Leu Pro  Pro Ala Ser Ser Pro  Pro Pro Pro Gln Val  Pro Gln Arg 
    1055                 1060                 1065             


Arg Gly  Thr Pro Pro Leu Thr  Pro Gly Arg Leu Thr  Gln Asp Leu 
    1070                 1075                 1080             


Lys Leu  Ile Ser Ala Ser Gln  Pro Ala Leu Pro Gln  Asp Gly Ala 
    1085                 1090                 1095             


Gln Thr  Leu Arg Arg Ala Ser  Pro His Ser Ser Gly  Glu Ser Met 
    1100                 1105                 1110             


Ala Ala  Phe Pro Leu Phe Pro  Arg Ala Gly Gly Gly  Ser Gly Gly 
    1115                 1120                 1125             


Ser Gly  Ser Ser Gly Gly Leu  Gly Pro Pro Gly Arg  Pro Tyr Gly 
    1130                 1135                 1140             


Ala Ile  Pro Gly Gln His Val  Thr Leu Pro Arg Lys  Thr Ser Ser 
    1145                 1150                 1155             


Gly Ser  Leu Pro Pro Pro Leu  Ser Leu Phe Gly Ala  Arg Ala Thr 
    1160                 1165                 1170             


Ser Ser  Gly Gly Pro Pro Leu  Thr Ala Gly Pro Gln  Arg Glu Pro 
    1175                 1180                 1185             


Gly Ala  Arg Pro Glu Pro Val  Arg Ser Lys Leu Pro  Ser Asn Leu 
    1190                 1195                 1200             


<210> 33
<211> 512
<212> PRT
<213> Homo sapiens

<400> 33
Met Asp Leu Lys Glu Ser Pro Ser Glu Gly Ser Leu Gln Pro Ser Ser 
1               5                   10                  15      


Ile Gln Ile Phe Ala Asn Thr Ser Thr Leu His Gly Ile Arg His Ile 
            20                  25                  30          


Phe Val Tyr Gly Pro Leu Thr Ile Arg Arg Val Leu Trp Ala Val Ala 
        35                  40                  45              


Phe Val Gly Ser Leu Gly Leu Leu Leu Val Glu Ser Ser Glu Arg Val 
    50                  55                  60                  


Ser Tyr Tyr Phe Ser Tyr Gln His Val Thr Lys Val Asp Glu Val Val 
65                  70                  75                  80  


Ala Gln Ser Leu Val Phe Pro Ala Val Thr Leu Cys Asn Leu Asn Gly 
                85                  90                  95      


Phe Arg Phe Ser Arg Leu Thr Thr Asn Asp Leu Tyr His Ala Gly Glu 
            100                 105                 110         


Leu Leu Ala Leu Leu Asp Val Asn Leu Gln Ile Pro Asp Pro His Leu 
        115                 120                 125             


Ala Asp Pro Ser Val Leu Glu Ala Leu Arg Gln Lys Ala Asn Phe Lys 
    130                 135                 140                 


His Tyr Lys Pro Lys Gln Phe Ser Met Leu Glu Phe Leu His Arg Val 
145                 150                 155                 160 


Gly His Asp Leu Lys Asp Met Met Leu Tyr Cys Lys Phe Lys Gly Gln 
                165                 170                 175     


Glu Cys Gly His Gln Asp Phe Thr Thr Val Phe Thr Lys Tyr Gly Lys 
            180                 185                 190         


Cys Tyr Met Phe Asn Ser Gly Glu Asp Gly Lys Pro Leu Leu Thr Thr 
        195                 200                 205             


Val Lys Gly Gly Thr Gly Asn Gly Leu Glu Ile Met Leu Asp Ile Gln 
    210                 215                 220                 


Gln Asp Glu Tyr Leu Pro Ile Trp Gly Glu Thr Glu Glu Thr Thr Phe 
225                 230                 235                 240 


Glu Ala Gly Val Lys Val Gln Ile His Ser Gln Ser Glu Pro Pro Phe 
                245                 250                 255     


Ile Gln Glu Leu Gly Phe Gly Val Ala Pro Gly Phe Gln Thr Phe Val 
            260                 265                 270         


Ala Thr Gln Glu Gln Arg Leu Thr Tyr Leu Pro Pro Pro Trp Gly Glu 
        275                 280                 285             


Cys Arg Ser Ser Glu Met Gly Leu Asp Phe Phe Pro Val Tyr Ser Ile 
    290                 295                 300                 


Thr Ala Cys Arg Ile Asp Cys Glu Thr Arg Tyr Ile Val Glu Asn Cys 
305                 310                 315                 320 


Asn Cys Arg Met Val His Met Pro Gly Asp Ala Pro Phe Cys Thr Pro 
                325                 330                 335     


Glu Gln His Lys Glu Cys Ala Glu Pro Ala Leu Gly Leu Leu Ala Glu 
            340                 345                 350         


Lys Asp Ser Asn Tyr Cys Leu Cys Arg Thr Pro Cys Asn Leu Thr Arg 
        355                 360                 365             


Tyr Asn Lys Glu Leu Ser Met Val Lys Ile Pro Ser Lys Thr Ser Ala 
    370                 375                 380                 


Lys Tyr Leu Glu Lys Lys Phe Asn Lys Ser Glu Lys Tyr Ile Ser Glu 
385                 390                 395                 400 


Asn Ile Leu Val Leu Asp Ile Phe Phe Glu Ala Leu Asn Tyr Glu Thr 
                405                 410                 415     


Ile Glu Gln Lys Lys Ala Tyr Glu Val Ala Ala Leu Leu Gly Asp Ile 
            420                 425                 430         


Gly Gly Gln Met Gly Leu Phe Ile Gly Ala Ser Ile Leu Thr Ile Leu 
        435                 440                 445             


Glu Leu Phe Asp Tyr Ile Tyr Glu Leu Ile Lys Glu Lys Leu Leu Asp 
    450                 455                 460                 


Leu Leu Gly Lys Glu Glu Asp Glu Gly Ser His Asp Glu Asn Val Ser 
465                 470                 475                 480 


Thr Cys Asp Thr Met Pro Asn His Ser Glu Thr Ile Ser His Thr Val 
                485                 490                 495     


Asn Val Pro Leu Gln Thr Thr Leu Gly Thr Leu Glu Glu Ile Ala Cys 
            500                 505                 510         


<210> 34
<211> 394
<212> PRT
<213> Homo sapiens

<400> 34
Met Lys Arg Gln Asn Val Arg Thr Leu Ala Leu Ile Val Cys Thr Phe 
1               5                   10                  15      


Thr Tyr Leu Leu Val Gly Ala Ala Val Phe Asp Ala Leu Glu Ser Glu 
            20                  25                  30          


Pro Glu Leu Ile Glu Arg Gln Arg Leu Glu Leu Arg Gln Gln Glu Leu 
        35                  40                  45              


Arg Ala Arg Tyr Asn Leu Ser Gln Gly Gly Tyr Glu Glu Leu Glu Arg 
    50                  55                  60                  


Val Val Leu Arg Leu Lys Pro His Lys Ala Gly Val Gln Trp Arg Phe 
65                  70                  75                  80  


Ala Gly Ser Phe Tyr Phe Ala Ile Thr Val Ile Thr Thr Ile Gly Tyr 
                85                  90                  95      


Gly His Ala Ala Pro Ser Thr Asp Gly Gly Lys Val Phe Cys Met Phe 
            100                 105                 110         


Tyr Ala Leu Leu Gly Ile Pro Leu Thr Leu Val Met Phe Gln Ser Leu 
        115                 120                 125             


Gly Glu Arg Ile Asn Thr Leu Val Arg Tyr Leu Leu His Arg Ala Lys 
    130                 135                 140                 


Lys Gly Leu Gly Met Arg Arg Ala Asp Val Ser Met Ala Asn Met Val 
145                 150                 155                 160 


Leu Ile Gly Phe Phe Ser Cys Ile Ser Thr Leu Cys Ile Gly Ala Ala 
                165                 170                 175     


Ala Phe Ser His Tyr Glu His Trp Thr Phe Phe Gln Ala Tyr Tyr Tyr 
            180                 185                 190         


Cys Phe Ile Thr Leu Thr Thr Ile Gly Phe Gly Asp Tyr Val Ala Leu 
        195                 200                 205             


Gln Lys Asp Gln Ala Leu Gln Thr Gln Pro Gln Tyr Val Ala Phe Ser 
    210                 215                 220                 


Phe Val Tyr Ile Leu Thr Gly Leu Thr Val Ile Gly Ala Phe Leu Asn 
225                 230                 235                 240 


Leu Val Val Leu Arg Phe Met Thr Met Asn Ala Glu Asp Glu Lys Arg 
                245                 250                 255     


Asp Ala Glu His Arg Ala Leu Leu Thr Arg Asn Gly Gln Ala Gly Gly 
            260                 265                 270         


Gly Gly Gly Gly Gly Ser Ala His Thr Thr Asp Thr Ala Ser Ser Thr 
        275                 280                 285             


Ala Ala Ala Gly Gly Gly Gly Phe Arg Asn Val Tyr Ala Glu Val Leu 
    290                 295                 300                 


His Phe Gln Ser Met Cys Ser Cys Leu Trp Tyr Lys Ser Arg Glu Lys 
305                 310                 315                 320 


Leu Gln Tyr Ser Ile Pro Met Ile Ile Pro Arg Asp Leu Ser Thr Ser 
                325                 330                 335     


Asp Thr Cys Val Glu Gln Ser His Ser Ser Pro Gly Gly Gly Gly Arg 
            340                 345                 350         


Tyr Ser Asp Thr Pro Ser Arg Arg Cys Leu Cys Ser Gly Ala Pro Arg 
        355                 360                 365             


Ser Ala Ile Ser Ser Val Ser Thr Gly Leu His Ser Leu Ser Thr Phe 
    370                 375                 380                 


Arg Gly Leu Met Lys Arg Arg Ser Ser Val 
385                 390                 


