                         SEQUENCE LISTING

<110>  INSTITUT PASTEUR
       BRUHNS, Pierre
       MANCARDI, David
       JONSSON, Friederike
       LAFAYE, Pierre
 
<120>  USE OF ANTI-FCGRI AND/OR FCGRIIA ANTIBODIES FOR TREATING 
       ARTHRITIS, INFLAMMATION, THROMBOCYTOPENIA AND ALLERGIC SHOCK

<130>  361989D31711

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of murine anti hFcgRI.1 CDR1 VH

<400>  1

Gly Phe Ser Leu Thr Thr Tyr Gly 
1               5               


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of murine anti hFcgRI.1 CDR2 VH

<400>  2

Ile Trp Ser Gly Gly Ser Thr 
1               5           


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of murine anti hFcgRI.1 CDR3 VH

<400>  3

Ala Arg Glu Trp Phe Ala Tyr 
1               5           


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of murine anti hFcgRI.1 CDR1 VL

<400>  4

Glu Asn Ile Tyr Ser Tyr 
1               5       


<210>  5
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of murine anti hFcgRI.1 CDR2 VL

<400>  5

Ser Ala Lys 
1           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of murine anti hFcgRI.1 CDR3 VL

<400>  6

Gln His His Tyr Gly Thr Pro Tyr Thr 
1               5                   


<210>  7
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro 
            180                 185                 190         


Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val 
        195                 200                 205             


Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln 
    210                 215                 220                 


Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn 
225                 230                 235                 240 


Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly 
                245                 250                 255     


Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg 
            260                 265                 270         


Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Gln Leu Pro Thr Pro 
        275                 280                 285             


Val Trp Phe His Val Leu Phe Tyr Leu Ala Val Gly Ile Met Phe Leu 
    290                 295                 300                 


Val Asn Thr Val Leu Trp Val Thr Ile Arg Lys Glu Leu Lys Arg Lys 
305                 310                 315                 320 


Lys Lys Trp Asp Leu Glu Ile Ser Leu Asp Ser Gly His Glu Lys Lys 
                325                 330                 335     


Val Ile Ser Ser Leu Gln Glu Asp Arg His Leu Glu Glu Glu Leu Lys 
            340                 345                 350         


Cys Gln Glu Gln Lys Glu Glu Gln Leu Gln Glu Gly Val His Arg Lys 
        355                 360                 365             


Glu Pro Gln Gly Ala Thr 
    370                 


<210>  8
<211>  314
<212>  PRT
<213>  Homo sapiens


<220>
<221>  NATURAL HUMAN RECEPTOR FcgRIIA = AAH20823.1 (variant H131)
<222>  (1)..(314)

<400>  8

Met Glu Thr Gln Met Ser Gln Asn Val Cys Pro Arg Asn Leu Trp Leu 
1               5                   10                  15      


Leu Gln Pro Leu Thr Val Leu Leu Leu Leu Ala Ser Ala Asp Ser Gln 
            20                  25                  30          


Ala Ala Pro Pro Lys Ala Val Leu Lys Leu Glu Pro Pro Trp Ile Asn 
        35                  40                  45              


Val Leu Gln Glu Asp Ser Val Thr Leu Thr Cys Gln Gly Ala Arg Ser 
    50                  55                  60                  


Pro Glu Ser Asp Ser Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro 
65                  70                  75                  80  


Thr His Thr Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser 
                85                  90                  95      


Gly Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val 
            100                 105                 110         


His Leu Thr Val Leu Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu 
        115                 120                 125             


Glu Phe Gln Glu Gly Glu Thr Ile Met Leu Arg Cys His Ser Trp Lys 
    130                 135                 140                 


Asp Lys Pro Leu Val Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Gln 
145                 150                 155                 160 


Lys Phe Ser His Leu Asp Pro Thr Phe Ser Ile Pro Gln Ala Asn His 
                165                 170                 175     


Ser His Ser Gly Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu 
            180                 185                 190         


Phe Ser Ser Lys Pro Val Thr Ile Thr Val Gln Val Pro Ser Met Gly 
        195                 200                 205             


Ser Ser Ser Pro Met Gly Val Ile Val Ala Val Val Ile Ala Thr Ala 
    210                 215                 220                 


Val Ala Ala Ile Val Ala Ala Val Val Ala Leu Ile Tyr Cys Arg Lys 
225                 230                 235                 240 


Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala Ala Gln Phe 
                245                 250                 255     


Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg Gln Leu Glu 
            260                 265                 270         


Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr Met Thr Leu 
        275                 280                 285             


Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr Leu Thr Leu 
    290                 295                 300                 


Pro Pro Asn Asp His Val Asn Ser Asn Asn 
305                 310                 


<210>  9
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of murine heavy chain variable region (VH) of
       anti-hFcgRI.1

<400>  9

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Trp Phe Ala Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  10
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of murine light chain variable region (VL) of
       anti- hFcgRI.1

<400>  10

Glu Leu Val Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ser Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Met Glu Ile Lys 
            100                 105         


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of murine anti hFcgRIIA CDR1 VH

<400>  11

Gly Tyr Thr Phe Thr Asn Tyr Gly 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of murine anti hFcgRIIA CDR2 VH

<400>  12

Leu Asn Thr Tyr Thr Gly Glu Ser 
1               5               


<210>  13
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of murine anti hFcgRIIA CDR3 VH

<400>  13

Ala Arg Gly Asp Tyr Gly Tyr Asp Asp Pro Leu Asp Tyr 
1               5                   10              


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of murine anti hFcgRIIA CDR1 VL

<400>  14

Lys Ser Leu Leu His Thr Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  15
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of murine anti hFcgRIIA CDR2 VL

<400>  15

Arg Met Ser Val 
1               


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of murine anti hFcgRIIA CDR3 VL

<400>  16

Met Gln His Leu Glu Tyr Pro Leu Thr 
1               5                   


<210>  17
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of heavy chain variable region (VH) of anti- hFcgRIIA

<400>  17

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Leu Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Pro Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Ser Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Gly Tyr Asp Asp Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  18
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of light chain variable region (VL) of anti- hFcgRIIA

<400>  18

Asp Val Val Met Thr Gln Thr Pro Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Thr 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Val Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Ser Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Phe Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  19
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of chimeric anti-FcgRI heavy chain (V mouse, C 
       human)

<400>  19

Met Gly Asp Asn Asp Ile His Phe Ala Phe Leu Ser Thr Gly Ala His 
1               5                   10                  15      


Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser 
            20                  25                  30          


Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr 
        35                  40                  45              


Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp 
    50                  55                  60                  


Leu Gly Met Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe 
65                  70                  75                  80  


Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe 
                85                  90                  95      


Phe Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys 
            100                 105                 110         


Ala Arg Glu Trp Phe Ala Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    130                 135                 140                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
145                 150                 155                 160 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                165                 170                 175     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            180                 185                 190         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        195                 200                 205             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    210                 215                 220                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        275                 280                 285             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    290                 295                 300                 


Arg Glu Glu Gln Tyr Asp Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
305                 310                 315                 320 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                325                 330                 335     


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            340                 345                 350         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        355                 360                 365             


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    370                 375                 380                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Val Ser Asn Gly Gln Pro 
385                 390                 395                 400 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                405                 410                 415     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            420                 425                 430         


Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Asn His 
        435                 440                 445             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460 


<210>  20
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of chimeric anti-FcgRI light chain (V mouse, C 
       human)

<400>  20

Met Gly Asp Asn Asp Ile His Phe Ala Phe Leu Ser Thr Gly Ala His 
1               5                   10                  15      


Ser Glu Leu Val Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val 
            20                  25                  30          


Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser 
        35                  40                  45              


Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu 
    50                  55                  60                  


Val Tyr Ser Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser 
65                  70                  75                  80  


Gly Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln 
                85                  90                  95      


Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Thr Pro 
            100                 105                 110         


Tyr Thr Phe Gly Gly Gly Thr Lys Met Glu Ile Lys Arg Thr Ala Ala 
        115                 120                 125             


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
    130                 135                 140                 


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
145                 150                 155                 160 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
                165                 170                 175     


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
            180                 185                 190         


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
        195                 200                 205             


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
    210                 215                 220                 


Ser Phe Asn Arg Gly Glu Cys 
225                 230     


<210>  21
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of chimeric anti-FcgRIIA heavy chain sequence (V 
       mouse, C human)

<400>  21

Met Gly Asp Asn Asp Ile His Phe Ala Phe Leu Ser Thr Gly Ala His 
1               5                   10                  15      


Ser Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly 
            20                  25                  30          


Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn 
        35                  40                  45              


Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp 
    50                  55                  60                  


Met Gly Trp Leu Asn Thr Tyr Thr Gly Glu Ser Ile Tyr Pro Asp Asp 
65                  70                  75                  80  


Phe Lys Gly Arg Phe Ala Phe Ser Ser Glu Thr Ser Ala Ser Thr Ala 
                85                  90                  95      


Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe 
            100                 105                 110         


Cys Ala Arg Gly Asp Tyr Gly Tyr Asp Asp Pro Leu Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asp Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Val Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  22
<211>  236
<212>  PRT
<213>  artificial sequence

<220>
<223>   Amino acid sequence of chimeric anti-FcgRIIA light chain (V mouse, C 
       human)

<400>  22

Met Gly Asp Asn Asp Ile His Phe Ala Phe Leu Ser Thr Gly Ala His 
1               5                   10                  15      


Ser Asp Val Val Met Thr Gln Thr Pro Pro Ser Val Pro Val Thr Pro 
            20                  25                  30          


Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His 
        35                  40                  45              


Thr Asn Gly Asn Thr Tyr Leu His Trp Phe Leu Gln Arg Pro Gly Gln 
    50                  55                  60                  


Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Val Leu Ala Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Ser 
                85                  90                  95      


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Phe Tyr Cys Met Gln 
            100                 105                 110         


His Leu Glu Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Thr Ala Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  23
<211>  1383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding chimeric anti-FcgRI heavy chain (V mouse, C 
       human)

<400>  23
atgggtgaca atgacatcca ctttgccttt ctctccacag gcgcgcactc cgaggtgcag       60

cttcaggagt caggacctgg cctagtgcag ccctcacaga gcctgtccat cacctgcaca      120

gtctctggtt tctcattgac tacctatggt gtacactggg ttcgccagtc tccaggaaag      180

ggtctggagt ggctgggaat gatatggagt ggtggaagca cagactataa tgcagctttc      240

atatccagac tgagcatcag caaggacaac tccaagagcc aagttttctt taaaatgaac      300

agtctgcaag ctgatgacac agccatatac tactgtgcca gagaatggtt tgcttactgg      360

ggccaaggaa cctcagtcac cgtctcctca gctagcacca agggcccatc ggtcttcccc      420

ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg cctggtcaag      480

gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac cagcggcgtg      540

cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag cgtggtgacc      600

gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca caagcccagc      660

aacaccaagg tcgacaagaa agttgagccc aaatcttgtg acaaaactca cacatgccca      720

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc      780

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      840

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc      900

aagacaaagc cgcgggagga gcagtacgac agcacgtacc gtgtggtcag cgtcctcacc      960

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1020

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1080

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1140

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggtgagcaa tgggcagccg     1200

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctat     1260

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1320

ttacatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc cccgggtaaa     1380

tga                                                                   1383


<210>  24
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding chimeric anti-FcgRI light chain (V mouse, C 
       human)

<400>  24
atgggtgaca atgacatcca ctttgccttt ctctccacag gcgcgcactc cgagctcgtg       60

atgacacagt ctccagcctc cctatctgca tctgtgggag aaactgtcac catcacatgt      120

cgagcaagtg agaatattta cagttattta gcatggtatc agcagaaaca gggaaaatct      180

cctcagctcc tggtctatag tgcaaaaacc ttagcagaag gtgtgccatc aaggttcagt      240

ggcagtggat caggcacaca gttttctctg aagatcaaca gcctgcagcc tgaagatttt      300

gggagttatt actgtcaaca tcattatggt actccgtaca cgttcggagg ggggaccaag      360

atggaaataa aacgcacggc ggccgcacca tctgtcttca tcttcccgcc atctgatgag      420

cagttgaaat ctggaactgc ctctgttgtg tgcctgctga ataacttcta tcccagagag      480

gccaaagtac agtggaaggt ggataacgcc ctccaatcgg gtaactccca ggagagtgtc      540

acagagcagg acagcaagga cagcacctac agcctcagca gcaccctgac gctgagcaaa      600

gcagactacg agaaacacaa agtctacgcc tgcgaagtca cccatcaggg cctgagttcg      660

cccgtcacaa agagcttcaa caggggagag tgctaa                                696


<210>  25
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding chimeric anti-FcgRIIA heavy chain seqence (V 
       mouse, C human)

<400>  25
atgggtgaca atgacatcca ctttgccttt ctctccacag gcgcgcactc cgagatccag       60

ctgcagcagt ctggacctga gctgaagaag cctggagaga cagtcaagat ctcctgcaag      120

gcttctgggt ataccttcac aaactatgga atgaactggg tgaagcaggc tccaggaaag      180

ggtttaaagt ggatgggctg gttaaacacc tacactggag agtcaatata tcctgatgac      240

ttcaagggac ggtttgcctt ctcttcggaa acctctgcca gcactgccta tttgcaaatc      300

aacaacctca aaaatgagga catggctaca tatttctgtg caagagggga ctatggttac      360

gacgaccctt tggactactg gggtcaagga acctcagtca ccgtctcctc agctagcacc      420

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      660

aacgtgaatc acaagcccag caacaccaag gtcgacaaga aagttgagcc caaatcttgt      720

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      840

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacga cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1080

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1200

tgggtgagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gttacatgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ccccgggtaa atga                                            1404


<210>  26
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding chimeric anti-FcgRIIA light chain (V mouse, C 
       human)

<400>  26
ggtgacaatg acatccactt tgcctttctc tccacaggcg cgcactccga tgttgtgatg       60

acccagactc caccctctgt acctgtcact cctggagagt cagtatccat ctcctgcagg      120

tctagtaaga gtctcctgca tactaatggc aacacttact tgcattggtt cctacagagg      180

ccaggccagt ctcctcagct cctgatatat cggatgtccg tccttgcctc aggagtccca      240

gacaggttca gtggcagtgg gtcaggaact gctttcacac tgagcatcag tagagtggag      300

gctgaggatg tgggtgtttt ttactgtatg caacatctag aatatccgct cacgttcggt      360

gctgggacca agctggaact gaaacgcacg gcggccgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagtt cgcccgtcac aaagagcttc aacaggggag agtgctaata a               711


<210>  27
<211>  314
<212>  PRT
<213>  Homo sapiens


<220>
<221>  amino acid sequence of human FcgRIIA variant R131
<222>  (1)..(314)

<400>  27

Met Glu Thr Gln Met Ser Gln Asn Val Cys Pro Arg Asn Leu Trp Leu 
1               5                   10                  15      


Leu Gln Pro Leu Thr Val Leu Leu Leu Leu Ala Ser Ala Asp Ser Gln 
            20                  25                  30          


Ala Ala Pro Pro Lys Ala Val Leu Lys Leu Glu Pro Pro Trp Ile Asn 
        35                  40                  45              


Val Leu Gln Glu Asp Ser Val Thr Leu Thr Cys Gln Gly Ala Arg Ser 
    50                  55                  60                  


Pro Glu Ser Asp Ser Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro 
65                  70                  75                  80  


Thr His Thr Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser 
                85                  90                  95      


Gly Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val 
            100                 105                 110         


His Leu Thr Val Leu Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu 
        115                 120                 125             


Glu Phe Gln Glu Gly Glu Thr Ile Met Leu Arg Cys His Ser Trp Lys 
    130                 135                 140                 


Asp Lys Pro Leu Val Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Gln 
145                 150                 155                 160 


Lys Phe Ser Arg Leu Asp Pro Thr Phe Ser Ile Pro Gln Ala Asn His 
                165                 170                 175     


Ser His Ser Gly Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu 
            180                 185                 190         


Phe Ser Ser Lys Pro Val Thr Ile Thr Val Gln Val Pro Ser Met Gly 
        195                 200                 205             


Ser Ser Ser Pro Met Gly Val Ile Val Ala Val Val Ile Ala Thr Ala 
    210                 215                 220                 


Val Ala Ala Ile Val Ala Ala Val Val Ala Leu Ile Tyr Cys Arg Lys 
225                 230                 235                 240 


Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala Ala Gln Phe 
                245                 250                 255     


Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg Gln Leu Glu 
            260                 265                 270         


Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr Met Thr Leu 
        275                 280                 285             


Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr Leu Thr Leu 
    290                 295                 300                 


Pro Pro Asn Asp His Val Asn Ser Asn Asn 
305                 310                 


<210>  28
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding VH (Heavy chain variable region) of anti-FcgRI.1

<400>  28
gaggtgcagc ttcaggagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc       60

acctgcacag tctctggttt ctcattgact acctatggtg tacactgggt tcgccagtct      120

ccaggaaagg gtctggagtg gctgggaatg atatggagtg gtggaagcac agactataat      180

gcagctttca tatccagact gagcatcagc aaggacaact ccaagagcca agttttcttt      240

aaaatgaaca gtctgcaagc tgatgacaca gccatatact actgtgccag agaatggttt      300

gcttactggg gccaaggaac ctcagtcacc gtctcctca                             339


<210>  29
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding VL of anti-FcgRI.1

<400>  29
gagctcgtga tgacacagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc       60

atcacatgtc gagcaagtga gaatatttac agttatttag catggtatca gcagaaacag      120

ggaaaatctc ctcagctcct ggtctatagt gcaaaaacct tagcagaagg tgtgccatca      180

aggttcagtg gcagtggatc aggcacacag ttttctctga agatcaacag cctgcagcct      240

gaagattttg ggagttatta ctgtcaacat cattatggta ctccgtacac gttcggaggg      300

gggaccaaga tggaaataaa a                                                321


