               SEQUENCE LISTING

<110> Administración General de la Comunidad Autónoma de Euskadi
      Universidad de Salamanca

<120> USO DE INHIBIDORES DE METALOPROTEASAS EN EL TRATAMIENTO DE ENFERMEDADES HEPÁTICAS POLIQUÍSTICAS

<130> PCT-06707

<150> ES201231850
<151> 2012-11-28

<160> 70

<170> BiSSAP 1.2

<210> 1
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen AE2"
      /organism="Artificial Sequence"

<400> 1
gctaagattt ggccatgagc                                                20


<210> 2
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen AE2"
      /organism="Artificial Sequence"

<400> 2
cggtggtatt caaagtcttc c                                              21


<210> 3
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen AQP1"
      /organism="Artificial Sequence"

<400> 3
tatgcgtgct ggctactacc                                                20


<210> 4
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen AQP1"
      /organism="Artificial Sequence"

<400> 4
agtcgtagat gagtacagcc                                                20


<210> 5
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..18
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen CK19"
      /organism="Artificial Sequence"

<400> 5
caacgaagct aaccatgc                                                  18


<210> 6
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen CK19"
      /organism="Artificial Sequence"

<400> 6
attggcttcg catgtcactc                                                20


<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen CK7"
      /organism="Artificial Sequence"

<400> 7
atctttgagg cccagattgc                                                20


<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen CK7"
      /organism="Artificial Sequence"

<400> 8
ttgatctcat cattcagggc                                                20


<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen GADPH"
      /organism="Artificial Sequence"

<400> 9
ccaaggtcat ccatgacaac                                                20


<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen GADPH"
      /organism="Artificial Sequence"

<400> 10
tgtcatacca ggaaatgagc                                                20


<210> 11
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen MMP-1"
      /organism="Artificial Sequence"

<400> 11
tcaaccaggc ccaggtatt                                                 19


<210> 12
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen MMP-1"
      /organism="Artificial Sequence"

<400> 12
tcaaccaggc ccaggtatt                                                 19


<210> 13
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..24
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen MMP-2"
      /organism="Artificial Sequence"

<400> 13
tgggagaagg ccaagtggtc cgtg                                           24


<210> 14
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..24
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen MMP-2"
      /organism="Artificial Sequence"

<400> 14
gtgcagctgt tgtactcctt gcca                                           24


<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen MMP-3"
      /organism="Artificial Sequence"

<400> 15
ccagggatta atggagatgc                                                20


<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen MMP-3"
      /organism="Artificial Sequence"

<400> 16
atcttgagac aggcggaacc                                                20


<210> 17
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen MMP-7"
      /organism="Artificial Sequence"

<400> 17
tgtatgggga actgctgac                                                 19


<210> 18
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen MMP-7"
      /organism="Artificial Sequence"

<400> 18
tcatcctcat cgaagtgagc                                                20


<210> 19
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen MMP-8"
      /organism="Artificial Sequence"

<400> 19
ctcaagatga catcgatggc                                                20


<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen MMP-8"
      /organism="Artificial Sequence"

<400> 20
tctttgtagc tgaggatgcc                                                20


<210> 21
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..23
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen MMP-9"
      /organism="Artificial Sequence"

<400> 21
aaggatacag tttgttcctc gtg                                            23


<210> 22
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..22
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen MMP-9"
      /organism="Artificial Sequence"

<400> 22
gcccctcagt gaagcggtac at                                             22


<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen MMP-10"
      /organism="Artificial Sequence"

<400> 23
aagttaacag cagggacacc                                                20


<210> 24
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen MMP-10"
      /organism="Artificial Sequence"

<400> 24
cttggataac ctgcttgtac c                                              21


<210> 25
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen MMP-11"
      /organism="Artificial Sequence"

<400> 25
agatctactt cttccgaggc                                                20


<210> 26
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen MMP-11"
      /organism="Artificial Sequence"

<400> 26
tccagagcct tcaccttcac                                                20


<210> 27
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen MMP-13"
      /organism="Artificial Sequence"

<400> 27
tgacgatgta caagggatcc                                                20


<210> 28
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen MMP-13"
      /organism="Artificial Sequence"

<400> 28
cattgtttct cctcggagac                                                20


<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen MMP-14"
      /organism="Artificial Sequence"

<400> 29
gacacccact ttgactctgc                                                20


<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen MMP-14"
      /organism="Artificial Sequence"

<400> 30
gcaaagtcga tgaggatgtc                                                20


<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen MMP-15"
      /organism="Artificial Sequence"

<400> 31
gaagtggaac aaccaccatc                                                20


<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen MMP-15"
      /organism="Artificial Sequence"

<400> 32
aagagtacca tgatgtcggc                                                20


<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen MMP-16"
      /organism="Artificial Sequence"

<400> 33
agcagtccat gaactgggac                                                20


<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen MMP-16"
      /organism="Artificial Sequence"

<400> 34
aggaatcttg tcaggtggac                                                20


<210> 35
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen MMP-17"
      /organism="Artificial Sequence"

<400> 35
caagtggaac aagaggaacc                                                20


<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen MMP-17"
      /organism="Artificial Sequence"

<400> 36
gagaagtcga tctggatgtc                                                20


<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen MMP-18"
      /organism="Artificial Sequence"

<400> 37
gcaagagaca tgatcatgcc                                                20


<210> 38
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen MMP-18"
      /organism="Artificial Sequence"

<400> 38
ttgtgccctg actcatgagc                                                20


<210> 39
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen MMP-24"
      /organism="Artificial Sequence"

<400> 39
catgcagatg catgctctgc                                                20


<210> 40
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen MMP-24"
      /organism="Artificial Sequence"

<400> 40
ccagaactgc tcgatctgc                                                 19


<210> 41
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen MMP-25"
      /organism="Artificial Sequence"

<400> 41
aaagtcatgc agaggttcgc                                                20


<210> 42
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen MMP-25"
      /organism="Artificial Sequence"

<400> 42
gaagacaaac atctcccctc                                                20


<210> 43
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen MMP-26"
      /organism="Artificial Sequence"

<400> 43
ctaccagtac atggagacgc                                                20


<210> 44
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen MMP-26"
      /organism="Artificial Sequence"

<400> 44
gcatggccta agataccacc                                                20


<210> 45
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen MMP-27"
      /organism="Artificial Sequence"

<400> 45
atcattggag tgagagagcc                                                20


<210> 46
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen MMP-27"
      /organism="Artificial Sequence"

<400> 46
atcattggag tgagagagcc                                                20


<210> 47
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen TIMP-1"
      /organism="Artificial Sequence"

<400> 47
gaaactagaa gccaacagcc                                                20


<210> 48
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen TIMP-1"
      /organism="Artificial Sequence"

<400> 48
agcaatgagt gccactctgc                                                20


<210> 49
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen TIMP-2"
      /organism="Artificial Sequence"

<400> 49
caaccctatc aagaggatcc                                                20


<210> 50
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen TIMP-2"
      /organism="Artificial Sequence"

<400> 50
agtcacagag ggtgatgtgc                                                20


<210> 51
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen TIMP-3"
      /organism="Artificial Sequence"

<400> 51
caacaagtac cagtacctgc                                                20


<210> 52
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen TIMP-3"
      /organism="Artificial Sequence"

<400> 52
tggaagtcac aaagcaaggc                                                20


<210> 53
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen TIMP-4"
      /organism="Artificial Sequence"

<400> 53
tgcggatact tccacaggtc                                                20


<210> 54
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen TIMP-4"
      /organism="Artificial Sequence"

<400> 54
ggtacagggt actgtgtagc                                                20


<210> 55
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen Col1a1"
      /organism="Artificial Sequence"

<400> 55
gactgtccca acccccaaaa                                                20


<210> 56
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen Col1a1"
      /organism="Artificial Sequence"

<400> 56
cttgggtccc tcgactccta                                                20


<210> 57
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..22
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen alpha-Sma"
      /organism="Artificial Sequence"

<400> 57
cgccatcagg aacctcgaga ag                                             22


<210> 58
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen alpha-Sma"
      /organism="Artificial Sequence"

<400> 58
atcatcacca gcaaagcccg                                                20


<210> 59
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen Tgfβ1"
      /organism="Artificial Sequence"

<400> 59
ctgctgaccc ccactgatac                                                20


<210> 60
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen Tgfβ1"
      /organism="Artificial Sequence"

<400> 60
agccctgtat tccgtctcct                                                20


<210> 61
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen Ctgf"
      /organism="Artificial Sequence"

<400> 61
ctagctgcct accgactgga                                                20


<210> 62
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen Ctgf"
      /organism="Artificial Sequence"

<400> 62
gcccatccca caggtcttag                                                20


<210> 63
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen Cxcl1"
      /organism="Artificial Sequence"

<400> 63
actcaagaat ggtcgcgagg                                                20


<210> 64
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen Cxcl1"
      /organism="Artificial Sequence"

<400> 64
acgccatcgg tgcaatctat                                                20


<210> 65
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen IL1β"
      /organism="Artificial Sequence"

<400> 65
aggctgacag accccaaaag                                                20


<210> 66
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen IL1β"
      /organism="Artificial Sequence"

<400> 66
ctccacgggc aagacatagg                                                20


<210> 67
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen Gapdh"
      /organism="Artificial Sequence"

<400> 67
tgtgaacgga tttggccgta                                                20


<210> 68
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen Gapdh"
      /organism="Artificial Sequence"

<400> 68
atgaaggggt cgttgatggc                                                20


<210> 69
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador sentido del gen IL-6"
      /organism="Artificial Sequence"

<400> 69
cattctgtct cgagcccacc                                                20


<210> 70
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Cebador antisentido del gen IL-6"
      /organism="Artificial Sequence"

<400> 70
agtcccaaga aggcaactgg                                                20


