                         SEQUENCE LISTING

<110>  AZZAZZY, HASSAN
       BALHORN, RODNEY
       AL OLABY, REEM
 
<120>  IDENTIFICATION OF LIGANDS THAT TARGET THE HCV-E2 BINDING SITE ON 
       CD81

<130>  402692WO

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  303
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  MISC_FEATURE
<222>  (1)..(303)
<223>  HCV E2 polypeptide tr|C4MR37|384-746

<400>  1

Tyr Asn Lys Phe Asn Ser Ser Gly Cys Ser Glu Arg Leu Ala Ser Cys 
1               5                   10                  15      


Arg Pro Leu Thr Asp Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Ala 
            20                  25                  30          


Asn Gly Ser Gly Pro Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro 
        35                  40                  45              


Arg Pro Cys Gly Ile Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr 
    50                  55                  60                  


Cys Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly 
65                  70                  75                  80  


Ala Pro Thr Tyr Ser Trp Gly Glu Asn Glu Thr Asp Val Phe Ile Leu 
                85                  90                  95      


Asn Asn Thr Arg Pro Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met 
            100                 105                 110         


Asn Ser Ser Gly Phe Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile 
        115                 120                 125             


Gly Gly Val Gly Asn Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg 
    130                 135                 140                 


Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile 
145                 150                 155                 160 


Thr Pro Arg Cys Leu Val Asn Tyr Pro Tyr Arg Leu Trp His Tyr Pro 
                165                 170                 175     


Cys Thr Ile Asn Tyr Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly 
            180                 185                 190         


Val Glu His Arg Leu Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg 
        195                 200                 205             


Cys Asp Leu Glu Asp Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu 
    210                 215                 220                 


Ser Thr Thr Gln Trp Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro 
225                 230                 235                 240 


Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val 
                245                 250                 255     


Gln Tyr Leu Tyr Gly Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys 
            260                 265                 270         


Trp Asp Tyr Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val 
        275                 280                 285             


Cys Ser Cys Leu Trp Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
    290                 295                 300             


<210>  2
<211>  236
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(236)
<223>  CD81 AMINO ACID SEQUENCE NP_004347.1

<400>  2

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
1               5                   10                  15      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            20                  25                  30          


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        35                  40                  45              


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
    50                  55                  60                  


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
65                  70                  75                  80  


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                85                  90                  95      


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
            100                 105                 110         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        115                 120                 125             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    130                 135                 140                 


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
145                 150                 155                 160 


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                165                 170                 175     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            180                 185                 190         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
        195                 200                 205             


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
    210                 215                 220                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr 
225                 230                 235     


<210>  3
<211>  90
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(90)
<223>  CD81 Chain A amino acid sequence. Re: Crystal Structure Of Human 
       CD81 Extracellular Domain 1G8Q_A  GI:13399775

<400>  3

Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
1               5                   10                  15      


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
            20                  25                  30          


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
        35                  40                  45              


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
    50                  55                  60                  


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
65                  70                  75                  80  


Lys Ile Asp Asp Leu Phe Ser Gly Lys His 
                85                  90  


<210>  4
<211>  90
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(90)
<223>  CD81 Chain B amino acid sequence.  Re: Crystal Structure Of Human
       CD81 Extracellular Domain 1G8Q_B  GI:13399776.

<400>  4

Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
1               5                   10                  15      


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
            20                  25                  30          


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
        35                  40                  45              


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
    50                  55                  60                  


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
65                  70                  75                  80  


Lys Ile Asp Asp Leu Phe Ser Gly Lys His 
                85                  90  


