                         SEQUENCE LISTING

<110>  Novartis AG
 
<120>  Optimized expression cassette for expressing a polypeptide with 
       high yield

<130>  PAT055302-WO-PCT

<150>  US 61/728,459
<151>  2012-11-20

<160>  15    

<170>  PatentIn version 3.3

<210>  1
<211>  288
<212>  DNA
<213>  artificial

<220>
<223>  5' UTR

<400>  1
agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac cgggaccgat     60

ccagcctccg cggccgggaa cggtgcattg gaacgcggat tccccgtgcc aagagtgacg    120

taagtaccgc ctatagagtc tataggccca cccccttggc ttcgttagaa cgcggctaca    180

attaatacat aaccttatgt atcatacaca tacgatttag gtgacactat agaataacat    240

ccactttgcc tttctctcca caggtgtcca ctcccaggtc caactgca                 288


<210>  2
<211>  302
<212>  DNA
<213>  artificial

<220>
<223>  5' UTR

<400>  2
agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac cgggaccgat     60

ccagcctccg cggccgggaa cggtgcattg gaacgcggat tccccgtgcc aagagtgacg    120

taagtaccgc ctatagagtc tataggccca cccccttggc ttcgttagaa cgcggctaca    180

attaatacat aaccttatgt atcatacaca tacgatttag gtgacactat agaataacat    240

ccactttgcc tttctctcca caggtgtcca ctcccaggtc caactgcacc tcggttctat    300

cg                                                                   302


<210>  3
<211>  316
<212>  DNA
<213>  artificial

<220>
<223>  5' UTR

<400>  3
agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac cgggaccgat     60

ccagcctccg cggccgggaa cggtgcattg gaacgcggat tccccgtgcc aagagtgacg    120

taagtaccgc ctatagagtc tataggccca cccccttggc ttcgttagaa cgcggctaca    180

attaatacat aaccttatgt atcatacaca tacgatttag gtgacactat agaataacat    240

ccactttgcc tttctctcca caggtgtcca ctcccaggtc caactgcacc tcggttctat    300

cgaaaacgcg tccacc                                                    316


<210>  4
<211>  352
<212>  DNA
<213>  artificial

<220>
<223>  5' UTR

<400>  4
agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac cgggaccgat     60

ccagcctccg cggccgggaa cggtgcattg gaacgcggat tccccgtgcc aagagtgacg    120

taagtaccgc ctatagagtc tataggccca cccccttggc ttcgttagaa cgcggctaca    180

attaatacat aaccttatgt atcatacaca tacgatttag gtgacactat agaataacat    240

ccactttgcc tttctctcca caggtgtcca ctcccaggtc caactgcacc tcggttctat    300

cgcgattgaa ttccccgggg atcctctagg gtgaccgttt ggtgccgcca cc            352


<210>  5
<211>  327
<212>  DNA
<213>  Artificial

<220>
<223>  5'UTR

<400>  5
agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac cgggaccgat     60

ccagcctccg cggccgggaa cggtgcattg gaacgcggat tccccgtgcc aagagtgacg    120

taagtaccgc ctatagagtc tataggccca cccccttggc ttcgttagaa cgcggctaca    180

attaatacat aaccttatgt atcatacaca tacgatttag gtgacactat agaataacat    240

ccactttgcc tttctctcca caggtgtcca ctcccaggtc caactgcacc tcggttctat    300

cgaaaacgcg cctctagagc cgccacc                                        327


<210>  6
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  5'UTR

<400>  6
agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac cgggaccgat     60

ccagcctccg cggccgggaa cggtgcattg gaacgcggat tccccgtgcc aagagtgacg    120

taagtaccgc ctatagagtc tataggccca cccccttggc ttcgttagaa cgcggctaca    180

attaatacat aaccttatgt atcatacaca tacgatttag gtgacactat agaataacat    240

ccactttgcc tttctctcca caggtgtcca ctcccaggtc caactgcacc tcggttctat    300

cgaaaaacgc gtgccgccac c                                              321


<210>  7
<211>  320
<212>  DNA
<213>  Artificial

<220>
<223>  5'UTR

<400>  7
agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac cgggaccgat     60

ccagcctccg cggccgggaa cggtgcattg gaacgcggat tccccgtgcc aagagtgacg    120

taagtaccgc ctatagagtc tataggccca cccccttggc ttcgttagaa cgcggctaca    180

attaatacat aaccttatgt atcatacaca tacgatttag gtgacactat agaataacat    240

ccactttgcc tttctctcca caggtgtcca ctcccaggtc caactgcacc tcggttctat    300

cgaaaacgcg tgccgccacc                                                320


<210>  8
<211>  737
<212>  DNA
<213>  hCMV

<400>  8
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta     60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc    120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg    180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc    240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat    300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc    360

ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga    420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg    480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacat    540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt    600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactc    660

cgccccattg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc    720

tcgtttagtg aaccgtc                                                   737


<210>  9
<211>  119
<212>  DNA
<213>  mouse

<400>  9
agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac cgggaccgat     60

ccagcctccg cggccgggaa cggtgcattg gaacgcggat tccccgtgcc aagagtgac     119


<210>  10
<211>  144
<212>  DNA
<213>  mouse

<400>  10
gtaagtaccg cctatagagt ctataggccc acccccttgg cttcgttaga acgcggctac     60

aattaataca taaccttatg tatcatacac atacgattta ggtgacacta tagaataaca    120

tccactttgc ctttctctcc acag                                           144


<210>  11
<211>  25
<212>  DNA
<213>  mouse

<400>  11
gtgtccactc ccaggtccaa ctgca                                           25


<210>  12
<211>  16
<212>  PRT
<213>  human

<400>  12

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


<210>  13
<211>  18
<212>  PRT
<213>  human

<400>  13

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp 
        


<210>  14
<211>  39
<212>  DNA
<213>  artificial

<220>
<223>  3' UTR

<400>  14
gggcggccgc ttccctttag tgagggttaa tgcttcgag                            39


<210>  15
<211>  222
<212>  DNA
<213>  artificial

<220>
<223>  poly A site

<400>  15
cagacatgat aagatacatt gatgagtttg gacaaaccac aactagaatg cagtgaaaaa     60

aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca    120

ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag ggggagatgt    180

gggaggtttt ttaaagcaag taaaacctct acaaatgtgg ta                       222


