                         SEQUENCE LISTING

<110>  William Beaumont Hospital
       Chancellor, Michael  B.
       Tyagi, Pradeep
       Tyagi, Vikas
 
<120>  Biomarker for the Diagnosis of Interstitial Cystitis

<130>  5475-346886

<150>  61/725599
<151>  2012-11-13

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  1
actcctccag cacctcgttg                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  2
gcttgccagg tcgtaggtca                                                   20


<210>  3
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  3
actcctccag cacctcgtt                                                    19


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  4
cttcatctcc ttgttgccct                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  5
gtactcctcc agcacctcgt                                                   20


<210>  6
<211>  3459
<212>  DNA
<213>  Homo sapiens

<400>  6
ggccggcggc ggcggcggcg gctccgctcc gcactgcccg gcgccgcctc gccatggacg       60

cgcgcggggg cggcgggcgg cccggggaga gcccgggcgc gacccccgcg ccggggccgc      120

cgccgccgcc gccgcccgcg cccccccaac agcagccgcc gccgccgccg ccgcccgcgc      180

cccccccggg ccccgggccc gcgccccccc agcacccgcc ccgggccgag gcgttgcccc      240

cggaggcggc ggatgagggc ggcccgcggg gccggctccg cagccgcgac agctcgtgcg      300

gccgccccgg caccccgggc gcggcgagca cggccaaggg cagcccgaac ggcgagtgcg      360

ggcgcggcga gccgcagtgc agccccgcgg ggcccgaggg cccggcgcgg gggcccaagg      420

tgtcgttctc gtgccgcggg gcggcctcgg ggcccgcgcc ggggccgggg ccggcggagg      480

aggcgggcag cgaggaggcg ggcccggcgg gggagccgcg cggcagccag gccagcttca      540

tgcagcgcca gttcggcgcg ctcctgcagc cgggcgtcaa caagttctcg ctgcggatgt      600

tcggcagcca gaaggccgtg gagcgcgagc aggagcgcgt caagtcggcg ggggcctgga      660

tcatccaccc gtacagcgac ttcaggttct actgggactt caccatgctg ctgttcatgg      720

tgggaaacct catcatcatc ccagtgggca tcaccttctt caaggatgag accactgccc      780

cgtggatcgt gttcaacgtg gtctcggaca ccttcttcct catggacctg gtgttgaact      840

tccgcaccgg cattgtgatc gaggacaaca cggagatcat cctggacccc gagaagatca      900

agaagaagta tctgcgcacg tggttcgtgg tggacttcgt gtcctccatc cccgtggact      960

acatcttcct tatcgtggag aagggcattg actccgaggt ctacaagacg gcacgcgccc     1020

tgcgcatcgt gcgcttcacc aagatcctca gcctcctgcg gctgctgcgc ctctcacgcc     1080

tgatccgcta catccatcag tgggaggaga tcttccacat gacctatgac ctggccagcg     1140

cggtgatgag gatctgcaat ctcatcagca tgatgctgct gctctgccac tgggacggct     1200

gcctgcagtt cctggtgcct atgctgcagg acttcccgcg caactgctgg gtgtccatca     1260

atggcatggt gaaccactcg tggagtgaac tgtactcctt cgcactcttc aaggccatga     1320

gccacatgct gtgcatcggg tacggccggc aggcgcccga gagcatgacg gacatctggc     1380

tgaccatgct cagcatgatt gtgggtgcca cctgctacgc catgttcatc ggccacgcca     1440

ctgccctcat ccagtcgctg gactcctcgc ggcgccagta ccaggagaag tacaagcagg     1500

tggagcagta catgtccttc cacaagctgc cagctgactt ccgccagaag atccacgact     1560

actatgagca ccgttaccag ggcaagatgt ttgacgagga cagcatcctg ggcgagctca     1620

acgggcccct gcgggaggag atcgtcaact tcaactgccg gaagctggtg gcctccatgc     1680

cgctgttcgc caacgccgac cccaacttcg tcacggccat gctgaccaag ctcaagttcg     1740

aggtcttcca gccgggtgac tacatcatcc gcgaaggcac catcgggaag aagatgtact     1800

tcatccagca cggcgtggtc agcgtgctca ctaagggcaa caaggagatg aagctgtccg     1860

atggctccta cttcggggag atctgcctgc tcacccgggg ccgccgcacg gcgagcgtgc     1920

gggctgacac ctactgccgc ctctattcgc tgagcgtgga caacttcaac gaggtgctgg     1980

aggagtaccc catgatgcgg cgcgccttcg agacggtggc catcgaccgc ctggaccgca     2040

tcggcaagaa gaattccatc ctcctgcaca aggtgcagca tgacctcaac tcgggcgtat     2100

tcaacaacca ggagaacgcc atcatccagg agatcgtcaa gtacgaccgc gagatggtgc     2160

agcaggccga gctgggtcag cgcgtgggcc tcttcccgcc gccgccgccg ccgccgcagg     2220

tcacctcggc catcgccacg ctgcagcagg cggcggccat gagcttctgc ccgcaggtgg     2280

cgcggccgct cgtggggccg ctggcgctcg gctcgccgcg cctcgtgcgc cgcccgcccc     2340

cggggcccgc acctgccgcc gcctcacccg ggcccccgcc ccccgccagc cccccgggcg     2400

cgcccgccag cccccgggca ccgcggacct cgccctacgg cggcctgccc gccgcccccc     2460

ttgctgggcc cgccctgccc gcgcgccgcc tgagccgcgc gtcgcgccca ctgtccgcct     2520

cgcagccctc gctgcctcac ggcgcccccg gccccgcggc ctccacacgc ccggccagca     2580

gctccacacc gcgcttgggg cccacgcccg ctgcccgggc cgccgcgccc agcccggacc     2640

gcagggactc ggcctcaccc ggcgccgccg gcggcctgga cccccaggac tccgcgcgct     2700

cgcgcctctc gtccaacttg tgaccctcgc cgaccgcccc gcgggcccag gcgggccggg     2760

ggcggggccg tcatccagac caaagccatg ccattgcgct gccccggccg ccagtccgcc     2820

cagaagccat agacgagacg taggtagccg tagttggacg gacgggcagg gccggcgggg     2880

cagccccctc cgcgcccccg gccgtccccc ctcatcgccc cgcgcccacc cccatcgccc     2940

ctgcccccgg cggcggcctc gcgtgcgagg gggctccctt cacctcggtg cctcagttcc     3000

cccagctgta agacagggac ggggcggccc agtggctgag aggagccggc tgtggagccc     3060

cgcccgcccc ccaccctcta ggtggccccc gtccgaggag gatcgttttc taagtgcaat     3120

acttggcccg ccggcttccc gctgccccca tcgcgctcac gcaataaccg gcccggcccc     3180

cgtccgcgcg cgtcccccgg tgacctcggg gagcagcacc ccgcctccct ccagcactgg     3240

caccgagagg caggcctggc tgcgcagggc gcggggggga ggctggggtc ccgccgccgt     3300

gatgaatgta ctgacgagcc gaggcagcag tgcccccacc gtggcccccc acgccccatt     3360

aacccccaca cccccattcc gcgcaataaa cgacagcatt ggcgccaaaa aaaaaaaaaa     3420

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                            3459


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  7
cgcctgatcc gctacatcca t                                                 21


<210>  8
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  8
agtgcgaagg agtacagttc act                                               23


<210>  9
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  9

Ser Ala Gly Asp Val Asp Thr Leu Ala Phe Asp Gly Arg Thr Phe Val 
1               5                   10                  15      


Glu Tyr Leu Asn Ala Val Thr Glu Ser Glu Leu Ala Asn Glu Ile Pro 
            20                  25                  30          


Val Pro Glu Thr Leu Asp Ser Gly Ala Leu His Glu Lys Ala Leu Gln 
        35                  40                  45              


Ser Asn His Phe Glu Leu Ser Leu Arg Thr Glu Ala Thr Gln Gly Leu 
    50                  55                  60                  


Val Leu Trp Ser Gly Lys Ala Thr Glu Arg Ala Asp Tyr Val Ala Leu 
65                  70                  75                  80  


Ala Ile Val Asp Gly His Leu Gln Leu Ser Tyr Asn Leu Gly Ser Gln 
                85                  90                  95      


Pro Val Val Leu Arg Ser Thr Val Pro Val Asn Thr Asn Arg Trp Leu 
            100                 105                 110         


Arg Val Val Ala His Arg Glu Gln Arg Glu Gly Ser Leu Gln Val Gly 
        115                 120                 125             


Asn Glu Ala Pro Val Thr Gly Ser Ser Pro Leu Gly Ala Thr Gln Leu 
    130                 135                 140                 


Asp Thr Asp Gly Ala Leu Trp Leu Gly Gly Leu Pro Glu Leu Pro Val 
145                 150                 155                 160 


Gly Pro Ala Leu Pro Lys Ala Tyr Gly Thr Gly Phe Val Gly Cys Leu 
                165                 170                 175     


Arg Asp Val Val Val Gly Arg His Pro Leu His Leu Leu Glu Asp Ala 
            180                 185                 190         


Val Thr Lys Pro Glu Leu Arg Pro Cys Pro Thr Pro 
        195                 200                 


<210>  10
<211>  2067
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Gly Arg Ser His Pro Gly Pro Leu Arg Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Ala Ala Cys Val Leu Pro Gly Ala Gly Gly Thr Cys Pro 
            20                  25                  30          


Glu Arg Ala Leu Glu Arg Arg Glu Glu Glu Ala Asn Val Val Leu Thr 
        35                  40                  45              


Gly Thr Val Glu Glu Ile Leu Asn Val Asp Pro Val Gln His Thr Tyr 
    50                  55                  60                  


Ser Cys Lys Val Arg Val Trp Arg Tyr Leu Lys Gly Lys Asp Leu Val 
65                  70                  75                  80  


Ala Arg Glu Ser Leu Leu Asp Gly Gly Asn Lys Val Val Ile Ser Gly 
                85                  90                  95      


Phe Gly Asp Pro Leu Ile Cys Asp Asn Gln Val Ser Thr Gly Asp Thr 
            100                 105                 110         


Arg Ile Phe Phe Val Asn Pro Ala Pro Pro Tyr Leu Trp Pro Ala His 
        115                 120                 125             


Lys Asn Glu Leu Met Leu Asn Ser Ser Leu Met Arg Ile Thr Leu Arg 
    130                 135                 140                 


Asn Leu Glu Glu Val Glu Phe Cys Val Glu Asp Lys Pro Gly Thr His 
145                 150                 155                 160 


Phe Thr Pro Val Pro Pro Thr Pro Pro Asp Ala Cys Arg Gly Met Leu 
                165                 170                 175     


Cys Gly Phe Gly Ala Val Cys Glu Pro Asn Ala Glu Gly Pro Gly Arg 
            180                 185                 190         


Ala Ser Cys Val Cys Lys Lys Ser Pro Cys Pro Ser Val Val Ala Pro 
        195                 200                 205             


Val Cys Gly Ser Asp Ala Ser Thr Tyr Ser Asn Glu Cys Glu Leu Gln 
    210                 215                 220                 


Arg Ala Gln Cys Ser Gln Gln Arg Arg Ile Arg Leu Leu Ser Arg Gly 
225                 230                 235                 240 


Pro Cys Gly Ser Arg Asp Pro Cys Ser Asn Val Thr Cys Ser Phe Gly 
                245                 250                 255     


Ser Thr Cys Ala Arg Ser Ala Asp Gly Leu Thr Ala Ser Cys Leu Cys 
            260                 265                 270         


Pro Ala Thr Cys Arg Gly Ala Pro Glu Gly Thr Val Cys Gly Ser Asp 
        275                 280                 285             


Gly Ala Asp Tyr Pro Gly Glu Cys Gln Leu Leu Arg Arg Ala Cys Ala 
    290                 295                 300                 


Arg Gln Glu Asn Val Phe Lys Lys Phe Asp Gly Pro Cys Asp Pro Cys 
305                 310                 315                 320 


Gln Gly Ala Leu Pro Asp Pro Ser Arg Ser Cys Arg Val Asn Pro Arg 
                325                 330                 335     


Thr Arg Arg Pro Glu Met Leu Leu Arg Pro Glu Ser Cys Pro Ala Arg 
            340                 345                 350         


Gln Ala Pro Val Cys Gly Asp Asp Gly Val Thr Tyr Glu Asn Asp Cys 
        355                 360                 365             


Val Met Gly Arg Ser Gly Ala Ala Arg Gly Leu Leu Leu Gln Lys Val 
    370                 375                 380                 


Arg Ser Gly Gln Cys Gln Gly Arg Asp Gln Cys Pro Glu Pro Cys Arg 
385                 390                 395                 400 


Phe Asn Ala Val Cys Leu Ser Arg Arg Gly Arg Pro Arg Cys Ser Cys 
                405                 410                 415     


Asp Arg Val Thr Cys Asp Gly Ala Tyr Arg Pro Val Cys Ala Gln Asp 
            420                 425                 430         


Gly Arg Thr Tyr Asp Ser Asp Cys Trp Arg Gln Gln Ala Glu Cys Arg 
        435                 440                 445             


Gln Gln Arg Ala Ile Pro Ser Lys His Gln Gly Pro Cys Asp Gln Ala 
    450                 455                 460                 


Pro Ser Pro Cys Leu Gly Val Gln Cys Ala Phe Gly Ala Thr Cys Ala 
465                 470                 475                 480 


Val Lys Asn Gly Gln Ala Ala Cys Glu Cys Leu Gln Ala Cys Ser Ser 
                485                 490                 495     


Leu Tyr Asp Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala 
            500                 505                 510         


Cys Glu Leu Glu Ala Thr Ala Cys Thr Leu Gly Arg Glu Ile Gln Val 
        515                 520                 525             


Ala Arg Lys Gly Pro Cys Asp Arg Cys Gly Gln Cys Arg Phe Gly Ala 
    530                 535                 540                 


Leu Cys Glu Ala Glu Thr Gly Arg Cys Val Cys Pro Ser Glu Cys Val 
545                 550                 555                 560 


Ala Leu Ala Gln Pro Val Cys Gly Ser Asp Gly His Thr Tyr Pro Ser 
                565                 570                 575     


Glu Cys Met Leu His Val His Ala Cys Thr His Gln Ile Ser Leu His 
            580                 585                 590         


Val Ala Ser Ala Gly Pro Cys Glu Thr Cys Gly Asp Ala Val Cys Ala 
        595                 600                 605             


Phe Gly Ala Val Cys Ser Ala Gly Gln Cys Val Cys Pro Arg Cys Glu 
    610                 615                 620                 


His Pro Pro Pro Gly Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly 
625                 630                 635                 640 


Ser Ala Cys Glu Leu Arg Glu Ala Ala Cys Leu Gln Gln Thr Gln Ile 
                645                 650                 655     


Glu Glu Ala Arg Ala Gly Pro Cys Glu Gln Ala Glu Cys Gly Ser Gly 
            660                 665                 670         


Gly Ser Gly Ser Gly Glu Asp Gly Asp Cys Glu Gln Glu Leu Cys Arg 
        675                 680                 685             


Gln Arg Gly Gly Ile Trp Asp Glu Asp Ser Glu Asp Gly Pro Cys Val 
    690                 695                 700                 


Cys Asp Phe Ser Cys Gln Ser Val Pro Gly Ser Pro Val Cys Gly Ser 
705                 710                 715                 720 


Asp Gly Val Thr Tyr Ser Thr Glu Cys Glu Leu Lys Lys Ala Arg Cys 
                725                 730                 735     


Glu Ser Gln Arg Gly Leu Tyr Val Ala Ala Gln Gly Ala Cys Arg Gly 
            740                 745                 750         


Pro Thr Phe Ala Pro Leu Pro Pro Val Ala Pro Leu His Cys Ala Gln 
        755                 760                 765             


Thr Pro Tyr Gly Cys Cys Gln Asp Asn Ile Thr Ala Ala Arg Gly Val 
    770                 775                 780                 


Gly Leu Ala Gly Cys Pro Ser Ala Cys Gln Cys Asn Pro His Gly Ser 
785                 790                 795                 800 


Tyr Gly Gly Thr Cys Asp Pro Ala Thr Gly Gln Cys Ser Cys Arg Pro 
                805                 810                 815     


Gly Val Gly Gly Leu Arg Cys Asp Arg Cys Glu Pro Gly Phe Trp Asn 
            820                 825                 830         


Phe Arg Gly Ile Val Thr Asp Gly Arg Ser Gly Cys Thr Pro Cys Ser 
        835                 840                 845             


Cys Asp Pro Gln Gly Ala Val Arg Asp Asp Cys Glu Gln Met Thr Gly 
    850                 855                 860                 


Leu Cys Ser Cys Lys Pro Gly Val Ala Gly Pro Lys Cys Gly Gln Cys 
865                 870                 875                 880 


Pro Asp Gly Arg Ala Leu Gly Pro Ala Gly Cys Glu Ala Asp Ala Ser 
                885                 890                 895     


Ala Pro Ala Thr Cys Ala Glu Met Arg Cys Glu Phe Gly Ala Arg Cys 
            900                 905                 910         


Val Glu Glu Ser Gly Ser Ala His Cys Val Cys Pro Met Leu Thr Cys 
        915                 920                 925             


Pro Glu Ala Asn Ala Thr Lys Val Cys Gly Ser Asp Gly Val Thr Tyr 
    930                 935                 940                 


Gly Asn Glu Cys Gln Leu Lys Thr Ile Ala Cys Arg Gln Gly Leu Gln 
945                 950                 955                 960 


Ile Ser Ile Gln Ser Leu Gly Pro Cys Gln Glu Ala Val Ala Pro Ser 
                965                 970                 975     


Thr His Pro Thr Ser Ala Ser Val Thr Val Thr Thr Pro Gly Leu Leu 
            980                 985                 990         


Leu Ser Gln Ala Leu Pro Ala Pro  Pro Gly Ala Leu Pro  Leu Ala Pro 
        995                 1000                 1005             


Ser Ser  Thr Ala His Ser Gln  Thr Thr Pro Pro Pro  Ser Ser Arg 
    1010                 1015                 1020             


Pro Arg  Thr Thr Ala Ser Val  Pro Arg Thr Thr Val  Trp Pro Val 
    1025                 1030                 1035             


Leu Thr  Val Pro Pro Thr Ala  Pro Ser Pro Ala Pro  Ser Leu Val 
    1040                 1045                 1050             


Ala Ser  Ala Phe Gly Glu Ser  Gly Ser Thr Asp Gly  Ser Ser Asp 
    1055                 1060                 1065             


Glu Glu  Leu Ser Gly Asp Gln  Glu Ala Ser Gly Gly  Gly Ser Gly 
    1070                 1075                 1080             


Gly Leu  Glu Pro Leu Glu Gly  Ser Ser Val Ala Thr  Pro Gly Pro 
    1085                 1090                 1095             


Pro Val  Glu Arg Ala Ser Cys  Tyr Asn Ser Ala Leu  Gly Cys Cys 
    1100                 1105                 1110             


Ser Asp  Gly Lys Thr Pro Ser  Leu Asp Ala Glu Gly  Ser Asn Cys 
    1115                 1120                 1125             


Pro Ala  Thr Lys Val Phe Gln  Gly Val Leu Glu Leu  Glu Gly Val 
    1130                 1135                 1140             


Glu Gly  Gln Glu Leu Phe Tyr  Thr Pro Glu Met Ala  Asp Pro Lys 
    1145                 1150                 1155             


Ser Glu  Leu Phe Gly Glu Thr  Ala Arg Ser Ile Glu  Ser Thr Leu 
    1160                 1165                 1170             


Asp Asp  Leu Phe Arg Asn Ser  Asp Val Lys Lys Asp  Phe Arg Ser 
    1175                 1180                 1185             


Val Arg  Leu Arg Asp Leu Gly  Pro Gly Lys Ser Val  Arg Ala Ile 
    1190                 1195                 1200             


Val Asp  Val His Phe Asp Pro  Thr Thr Ala Phe Arg  Ala Pro Asp 
    1205                 1210                 1215             


Val Ala  Arg Ala Leu Leu Arg  Gln Ile Gln Val Ser  Arg Arg Arg 
    1220                 1225                 1230             


Ser Leu  Gly Val Arg Arg Pro  Leu Gln Glu His Val  Arg Phe Met 
    1235                 1240                 1245             


Asp Phe  Asp Trp Phe Pro Ala  Phe Ile Thr Gly Ala  Thr Ser Gly 
    1250                 1255                 1260             


Ala Ile  Ala Ala Gly Ala Thr  Ala Arg Ala Thr Thr  Ala Ser Arg 
    1265                 1270                 1275             


Leu Pro  Ser Ser Ala Val Thr  Pro Arg Ala Pro His  Pro Ser His 
    1280                 1285                 1290             


Thr Ser  Gln Pro Val Ala Lys  Thr Thr Ala Ala Pro  Thr Thr Arg 
    1295                 1300                 1305             


Arg Pro  Pro Thr Thr Ala Pro  Ser Arg Val Pro Gly  Arg Arg Pro 
    1310                 1315                 1320             


Pro Ala  Pro Gln Gln Pro Pro  Lys Pro Cys Asp Ser  Gln Pro Cys 
    1325                 1330                 1335             


Phe His  Gly Gly Thr Cys Gln  Asp Trp Ala Leu Gly  Gly Gly Phe 
    1340                 1345                 1350             


Thr Cys  Ser Cys Pro Ala Gly  Arg Gly Gly Ala Val  Cys Glu Lys 
    1355                 1360                 1365             


Val Leu  Gly Ala Pro Val Pro  Ala Phe Glu Gly Arg  Ser Phe Leu 
    1370                 1375                 1380             


Ala Phe  Pro Thr Leu Arg Ala  Tyr His Thr Leu Arg  Leu Ala Leu 
    1385                 1390                 1395             


Glu Phe  Arg Ala Leu Glu Pro  Gln Gly Leu Leu Leu  Tyr Asn Gly 
    1400                 1405                 1410             


Asn Ala  Arg Gly Lys Asp Phe  Leu Ala Leu Ala Leu  Leu Asp Gly 
    1415                 1420                 1425             


Arg Val  Gln Leu Arg Phe Asp  Thr Gly Ser Gly Pro  Ala Val Leu 
    1430                 1435                 1440             


Thr Ser  Ala Val Pro Val Glu  Pro Gly Gln Trp His  Arg Leu Glu 
    1445                 1450                 1455             


Leu Ser  Arg His Trp Arg Arg  Gly Thr Leu Ser Val  Asp Gly Glu 
    1460                 1465                 1470             


Thr Pro  Val Leu Gly Glu Ser  Pro Ser Gly Thr Asp  Gly Leu Asn 
    1475                 1480                 1485             


Leu Asp  Thr Asp Leu Phe Val  Gly Gly Val Pro Glu  Asp Gln Ala 
    1490                 1495                 1500             


Ala Val  Ala Leu Glu Arg Thr  Phe Val Gly Ala Gly  Leu Arg Gly 
    1505                 1510                 1515             


Cys Ile  Arg Leu Leu Asp Val  Asn Asn Gln Arg Leu  Glu Leu Gly 
    1520                 1525                 1530             


Ile Gly  Pro Gly Ala Ala Thr  Arg Gly Ser Gly Val  Gly Glu Cys 
    1535                 1540                 1545             


Gly Asp  His Pro Cys Leu Pro  Asn Pro Cys His Gly  Gly Ala Pro 
    1550                 1555                 1560             


Cys Gln  Asn Leu Glu Ala Gly  Arg Phe His Cys Gln  Cys Pro Pro 
    1565                 1570                 1575             


Gly Arg  Val Gly Pro Thr Cys  Ala Asp Glu Lys Ser  Pro Cys Gln 
    1580                 1585                 1590             


Pro Asn  Pro Cys His Gly Ala  Ala Pro Cys Arg Val  Leu Pro Glu 
    1595                 1600                 1605             


Gly Gly  Ala Gln Cys Glu Cys  Pro Leu Gly Arg Glu  Gly Thr Phe 
    1610                 1615                 1620             


Cys Gln  Thr Ala Ser Gly Gln  Asp Gly Ser Gly Pro  Phe Leu Ala 
    1625                 1630                 1635             


Asp Phe  Asn Gly Phe Ser His  Leu Glu Leu Arg Gly  Leu His Thr 
    1640                 1645                 1650             


Phe Ala  Arg Asp Leu Gly Glu  Lys Met Ala Leu Glu  Val Val Phe 
    1655                 1660                 1665             


Leu Ala  Arg Gly Pro Ser Gly  Leu Leu Leu Tyr Asn  Gly Gln Lys 
    1670                 1675                 1680             


Thr Asp  Gly Lys Gly Asp Phe  Val Ser Leu Ala Leu  Arg Asp Arg 
    1685                 1690                 1695             


Arg Leu  Glu Phe Arg Tyr Asp  Leu Gly Lys Gly Ala  Ala Val Ile 
    1700                 1705                 1710             


Arg Ser  Arg Glu Pro Val Thr  Leu Gly Ala Trp Thr  Arg Val Ser 
    1715                 1720                 1725             


Leu Glu  Arg Asn Gly Arg Lys  Gly Ala Leu Arg Val  Gly Asp Gly 
    1730                 1735                 1740             


Pro Arg  Val Leu Gly Glu Ser  Pro Lys Ser Arg Lys  Val Pro His 
    1745                 1750                 1755             


Thr Val  Leu Asn Leu Lys Glu  Pro Leu Tyr Val Gly  Gly Ala Pro 
    1760                 1765                 1770             


Asp Phe  Ser Lys Leu Ala Arg  Ala Ala Ala Val Ser  Ser Gly Phe 
    1775                 1780                 1785             


Asp Gly  Ala Ile Gln Leu Val  Ser Leu Gly Gly Arg  Gln Leu Leu 
    1790                 1795                 1800             


Thr Pro  Glu His Val Leu Arg  Gln Val Asp Val Thr  Ser Phe Ala 
    1805                 1810                 1815             


Gly His  Pro Cys Thr Arg Ala  Ser Gly His Pro Cys  Leu Asn Gly 
    1820                 1825                 1830             


Ala Ser  Cys Val Pro Arg Glu  Ala Ala Tyr Val Cys  Leu Cys Pro 
    1835                 1840                 1845             


Gly Gly  Phe Ser Gly Pro His  Cys Glu Lys Gly Leu  Val Glu Lys 
    1850                 1855                 1860             


Ser Ala  Gly Asp Val Asp Thr  Leu Ala Phe Asp Gly  Arg Thr Phe 
    1865                 1870                 1875             


Val Glu  Tyr Leu Asn Ala Val  Thr Glu Ser Glu Leu  Ala Asn Glu 
    1880                 1885                 1890             


Ile Pro  Val Pro Glu Thr Leu  Asp Ser Gly Ala Leu  His Glu Lys 
    1895                 1900                 1905             


Ala Leu  Gln Ser Asn His Phe  Glu Leu Ser Leu Arg  Thr Glu Ala 
    1910                 1915                 1920             


Thr Gln  Gly Leu Val Leu Trp  Ser Gly Lys Ala Thr  Glu Arg Ala 
    1925                 1930                 1935             


Asp Tyr  Val Ala Leu Ala Ile  Val Asp Gly His Leu  Gln Leu Ser 
    1940                 1945                 1950             


Tyr Asn  Leu Gly Ser Gln Pro  Val Val Leu Arg Ser  Thr Val Pro 
    1955                 1960                 1965             


Val Asn  Thr Asn Arg Trp Leu  Arg Val Val Ala His  Arg Glu Gln 
    1970                 1975                 1980             


Arg Glu  Gly Ser Leu Gln Val  Gly Asn Glu Ala Pro  Val Thr Gly 
    1985                 1990                 1995             


Ser Ser  Pro Leu Gly Ala Thr  Gln Leu Asp Thr Asp  Gly Ala Leu 
    2000                 2005                 2010             


Trp Leu  Gly Gly Leu Pro Glu  Leu Pro Val Gly Pro  Ala Leu Pro 
    2015                 2020                 2025             


Lys Ala  Tyr Gly Thr Gly Phe  Val Gly Cys Leu Arg  Asp Val Val 
    2030                 2035                 2040             


Val Gly  Arg His Pro Leu His  Leu Leu Glu Asp Ala  Val Thr Lys 
    2045                 2050                 2055             


Pro Glu  Leu Arg Pro Cys Pro  Thr Pro 
    2060                 2065         


